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CHANGELOG.md

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2023/06

Added suboptimal folding for t22:

  • Uses same Expansion struct as for randomised traceback
  • Pairs are handled explicitly in the State rather than implicitly like in t04 by looking at the DP tables (for DP_P)

Added SHAPE support for t22:

  • add pf_paired and pf_unpaired vectors to the energy model - these are pseudofree energy penalties for each nucleotide
  • Each substructure handles paired pseudofree energy for its opening pair.
  • Closing pairs are the opening pair of the next substructure, and are handled by it.
  • Unlike RNAstructure:
    • unpaired pseudofree energy is applied for special hairpins hairpins.
    • paired pseudofree energy is not double counted inside helices or missed for lonely pairs
    • paired pseudofree energy is counted across a size 1 bulge loop