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EAD electron activated dissociation as child of MS:1000044 #158

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meier-rene opened this issue Sep 21, 2022 · 0 comments · Fixed by #159
Closed

EAD electron activated dissociation as child of MS:1000044 #158

meier-rene opened this issue Sep 21, 2022 · 0 comments · Fixed by #159

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@meier-rene
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Describe the new term or terms you would like to add.

Hi,
I'm one of the maintainers of MassBank. We got a request of a contributor to include a dissociation method called "electron activated dissociation" (EAD). Its available at the Sciex ZenoTOF 7600 instrument. In principle its a subtype of ECD or similar to ECD, but the description of ECD "A process in which a multiply protonated molecules interacts with a low energy electrons. Capture of the electron leads the liberation of energy and a reduction in charge state of the ion with the production of the (M + nH) (n-1)+ odd electron ion, which readily fragments." is very much tailored to proteomics and does not apply to all possible usecases of EAD. Thats why I'm asking for a child of MS:1000044 with the name "electron activated dissociation" and the abbreviation EAD. As description I suggest "A process to fragment ions in a high intensity electron beam which results in a dissociation of various analytes ranging from singly charged small molecules to multiply protonated proteins."

In addition I'm asking for the addition of the instrument as a child of MS:1000121 with the name "ZenoTOF 7600"

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