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cn_syn.g
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cn_syn.g
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// genesis
// create synapses (based on Gauck and Jaeger 2003)
function make_cn_syns
if (!({exists AMPA}))
create synchan AMPA
end
setfield AMPA Ek {E_AMPA} tau1 {tauRise_AMPA} tau2 {tauFall_AMPA} \
gmax 0 frequency 0
if (!({exists fNMDA}))
create synchan fNMDA
end
setfield fNMDA Ek {E_NMDA} tau1 {tauRise_fNMDA} tau2 {tauFall_fNMDA} \
gmax 0 frequency 0
if (!({exists Mg_fblock}))
create Mg_block Mg_fblock
end
setfield Mg_fblock \
CMg 0.002 \
KMg_A 1 \
KMg_B {1.0/{0.109*1000}}
if (!({exists sNMDA}))
create synchan sNMDA
end
setfield sNMDA Ek {E_NMDA} tau1 {tauRise_sNMDA} tau2 {tauFall_sNMDA} \
gmax 0 frequency 0
if (!({exists Mg_sblock}))
create Mg_block Mg_sblock
end
setfield Mg_sblock \
CMg 0.25 \
KMg_A 1 \
KMg_B {1/{0.057*1000}}
if (!({exists GABA}))
create synchan GABA
end
setfield GABA Ek {E_GABA} tau1 {tauRise_GABA} tau2 {tauFall_GABA} \
gmax 0 frequency 0
end
// add synapses to soma
function add_soma_syns
copy /library/GABA soma/GABAs
setfield soma/GABAs gmax {G_GABAs}
addmsg soma/GABAs soma CHANNEL Gk Ek
addmsg soma soma/GABAs VOLTAGE Vm
copy /library/AMPA soma/AMPAs
setfield soma/AMPAs gmax {G_AMPAs}
addmsg soma/AMPAs soma CHANNEL Gk Ek
addmsg soma soma/AMPAs VOLTAGE Vm
copy /library/fNMDA soma/fNMDAs
setfield soma/fNMDAs gmax {G_fNMDAs}
copy /library/Mg_fblock soma/Mg_fblocks
addmsg soma/fNMDAs soma/Mg_fblocks CHANNEL Gk Ek
addmsg soma/Mg_fblocks soma CHANNEL Gk Ek
addmsg soma soma/Mg_fblocks VOLTAGE Vm
addmsg soma soma/fNMDAs VOLTAGE Vm
copy /library/sNMDA soma/sNMDAs
setfield soma/sNMDAs gmax {G_sNMDAs}
copy /library/Mg_sblock soma/Mg_sblocks
addmsg soma/sNMDAs soma/Mg_sblocks CHANNEL Gk Ek
addmsg soma/Mg_sblocks soma CHANNEL Gk Ek
addmsg soma soma/Mg_sblocks VOLTAGE Vm
addmsg soma soma/sNMDAs VOLTAGE Vm
//set up timetables and input to soma
if (!{exists /inputs})
create neutral /inputs
end
create neutral /inputs/soma
if ({ex_rate_s} > 0)
create timetable /inputs/soma/ex_tt
setfield /inputs/soma/ex_tt \
maxtime {synmaxtime} act_val 1.0 method 2 \
meth_desc1 {1/{ex_rate_s}} \
meth_desc2 0 meth_desc3 3
call /inputs/soma/ex_tt TABFILL
create spikegen /inputs/soma/ex_spikegen
setfield /inputs/soma/ex_spikegen output_amp 1 thresh 0.5
addmsg /inputs/soma/ex_tt /inputs/soma/ex_spikegen INPUT activation
addmsg /inputs/soma/ex_spikegen soma/AMPAs SPIKE
addmsg /inputs/soma/ex_spikegen soma/fNMDAs SPIKE
addmsg /inputs/soma/ex_spikegen soma/sNMDAs SPIKE
end
if ({inhib_rate_s} > 0)
create timetable /inputs/soma/inhib_tt
setfield /inputs/soma/inhib_tt \
maxtime {synmaxtime} act_val 1.0 method 2 \
meth_desc1 {1/{inhib_rate_s}} \
meth_desc2 0 meth_desc3 3
call /inputs/soma/inhib_tt TABFILL
create spikegen /inputs/soma/inhib_spikegen
setfield /inputs/soma/inhib_spikegen output_amp 1 thresh 0.5
addmsg /inputs/soma/inhib_tt /inputs/soma/inhib_spikegen INPUT activation
addmsg /inputs/soma/inhib_spikegen soma/GABAs SPIKE
end
end
// add synapses to dendritic compartments
function add_dend_syns
int i
str mfincomp, pcincomp
if (!{exists /inputs})
create neutral /inputs
end
// add excitory synapses to set of compartments (read in from file)
openfile {MF_infile} r
randseed {MF_seed}
for (i = 1; i <= {no_MF}; i = i + 1)
mfincomp = {readfile {MF_infile}}
copy /library/AMPA {mfincomp}/AMPAd
setfield {mfincomp}/AMPAd gmax {G_AMPAd}
addmsg {mfincomp}/AMPAd {mfincomp} CHANNEL Gk Ek
addmsg {mfincomp} {mfincomp}/AMPAd VOLTAGE Vm
copy /library/fNMDA {mfincomp}/fNMDAd
setfield {mfincomp}/fNMDAd gmax {G_fNMDAd}
copy /library/Mg_fblock {mfincomp}/Mg_fblockd
addmsg {mfincomp}/fNMDAd {mfincomp}/Mg_fblockd CHANNEL Gk Ek
addmsg {mfincomp}/Mg_fblockd {mfincomp} CHANNEL Gk Ek
addmsg {mfincomp} {mfincomp}/Mg_fblockd VOLTAGE Vm
addmsg {mfincomp} {mfincomp}/fNMDAd VOLTAGE Vm
copy /library/sNMDA {mfincomp}/sNMDAd
setfield {mfincomp}/sNMDAd gmax {G_sNMDAd}
copy /library/Mg_sblock {mfincomp}/Mg_sblockd
addmsg {mfincomp}/sNMDAd {mfincomp}/Mg_sblockd CHANNEL Gk Ek
addmsg {mfincomp}/Mg_sblockd {mfincomp} CHANNEL Gk Ek
addmsg {mfincomp} {mfincomp}/Mg_sblockd VOLTAGE Vm
addmsg {mfincomp} {mfincomp}/sNMDAd VOLTAGE Vm
create neutral /inputs/{mfincomp}
if ({ex_rate_d} > 0)
create timetable /inputs/{mfincomp}/ex_tt
setfield /inputs/{mfincomp}/ex_tt \
maxtime {synmaxtime} act_val 1.0 method 2 \
meth_desc1 {1/{ex_rate_d}} meth_desc2 0 meth_desc3 3
call /inputs/{mfincomp}/ex_tt TABFILL
create spikegen /inputs/{mfincomp}/ex_spikegen
setfield /inputs/{mfincomp}/ex_spikegen output_amp 1 thresh 0.5
addmsg /inputs/{mfincomp}/ex_tt /inputs/{mfincomp}/ex_spikegen INPUT activation
addmsg /inputs/{mfincomp}/ex_spikegen {mfincomp}/AMPAd SPIKE
addmsg /inputs/{mfincomp}/ex_spikegen {mfincomp}/fNMDAd SPIKE
addmsg /inputs/{mfincomp}/ex_spikegen {mfincomp}/sNMDAd SPIKE
end
end
closefile {MF_infile}
// add inhibitory synapses to another set of compartments (read in from file)
openfile {PC_infile} r
randseed {PC_seed}
for (i = 1; i <= {no_PC}; i = i + 1)
pcincomp = {readfile {PC_infile}}
copy /library/GABA {pcincomp}/GABAd
setfield {pcincomp}/GABAd gmax {G_GABAd}
addmsg {pcincomp}/GABAd {pcincomp} CHANNEL Gk Ek
addmsg {pcincomp} {pcincomp}/GABAd VOLTAGE Vm
if(!{exists /inputs/{pcincomp}})
create neutral /inputs/{pcincomp}
end
if ({inhib_rate_d} > 0)
create timetable /inputs/{pcincomp}/inhib_tt
setfield /inputs/{pcincomp}/inhib_tt \
maxtime {synmaxtime} act_val 1.0 method 2 \
meth_desc1 {1/{inhib_rate_d}} meth_desc2 0 meth_desc3 3
call /inputs/{pcincomp}/inhib_tt TABFILL
create spikegen /inputs/{pcincomp}/inhib_spikegen
setfield /inputs/{pcincomp}/inhib_spikegen output_amp 1 thresh 0.5
addmsg /inputs/{pcincomp}/inhib_tt /inputs/{pcincomp}/inhib_spikegen INPUT activation
addmsg /inputs/{pcincomp}/inhib_spikegen {pcincomp}/GABAd SPIKE
end
end
closefile {PC_infile}
end
// update timetables for synaptic input bursts
function add_synburst
int i
str pcincomp
str mfincomp
int nextseed
silent 1
if (exbdur > 0 && exbrate > 0)
randseed {MF_seed}
nextseed = {rand 100000 999999}
if (ex_rate_s > 0)
call /inputs/soma/ex_tt TUPDATE 2 {exbonset} {{exbonset} + {exbdur}} {1.0 / {{exbrate}*50}}
randseed {nextseed}
nextseed = {rand 100000 999999}
else
create timetable /inputs/soma/ex_tt
setfield /inputs/soma/ex_tt \
maxtime {{exbonset} + {exbdur}} act_val 1.0 method 2 \
meth_desc1 {1/{{exbrate}*50}} \
meth_desc2 0 meth_desc3 3
call /inputs/soma/ex_tt TABFILL
// Next line takes baseline_rate back to near-zero.
call /inputs/soma/ex_tt TUPDATE 2 0 {exbonset} {10000}
create spikegen /inputs/soma/ex_spikegen
setfield /inputs/soma/ex_spikegen output_amp 1 thresh 0.5
addmsg /inputs/soma/ex_tt /inputs/soma/ex_spikegen INPUT activation
addmsg /inputs/soma/ex_spikegen soma/AMPAs SPIKE
end
end
if(inb1dur > 0)
randseed {PC_seed}
nextseed = {rand 100000 999999}
if (inhib_rate_s > 0)
// Two inhibitory bursts follow each other, inb1 is first and determines onset
if(inb1rate > 0)
call /inputs/soma/inhib_tt TUPDATE 2 {inb1onset} {{inb1onset} + {inb1dur}} {1.0 / {{inb1rate}*50}}
end
randseed {nextseed}
nextseed = {rand 100000 999999}
if(inb2dur > 0)
call /inputs/soma/inhib_tt TUPDATE 2 {{inb1onset} + {inb1dur}} {{inb1onset} + {inb1dur} + {inb2dur}} {1.0 / {{inb2fac}*{inhib_rate_s}}}
end
randseed {nextseed}
nextseed = {rand 100000 999999}
else
if(inb1rate > 0)
create timetable /inputs/soma/inhib_tt
setfield /inputs/soma/inhib_tt \
maxtime {{inb1onset} + {inb1dur} + {inb2dur}} act_val 1.0 method 2 \
meth_desc1 {1/{{inb1rate}*50}} \
meth_desc2 0 meth_desc3 3
call /inputs/soma/inhib_tt TABFILL
if(inb2dur > 0)
call /inputs/soma/inhib_tt TUPDATE 2 {{inb1onset} + {inb1dur}} {{inb1onset} + {inb1dur} + {inb2dur}} {1.0 / {{inb2fac}*{inhib_rate_s}}}
end
// Next line takes baseline_rate back to near-zero.
call /inputs/soma/inhib_tt TUPDATE 2 0 {inb1onset} {10000}
create spikegen /inputs/soma/inhib_spikegen
setfield /inputs/soma/inhib_spikegen output_amp 1 thresh 0.5
addmsg /inputs/soma/inhib_tt /inputs/soma/inhib_spikegen INPUT activation
addmsg /inputs/soma/inhib_spikegen soma/GABAs SPIKE
end
end
end
randseed {nextseed}
nextseed = {rand 100000 999999}
if (exbdur > 0 && exbrate > 0)
openfile {MF_infile} r
for (i = 1; i <= {no_MF}; i = i + 1)
mfincomp = {readfile {MF_infile}}
if (ex_rate_d > 0)
call /inputs/{mfincomp}/ex_tt TUPDATE 2 {exbonset} {{exbonset} + {exbdur}} {1.0 / {exbrate}}
else
if(!{exists /inputs/{mfincomp}})
create neutral /inputs/{mfincomp}
end
create timetable /inputs/{mfincomp}/ex_tt
setfield /inputs/{mfincomp}/ex_tt \
maxtime {{exbonset} + {exbdur}} act_val 1.0 method 2 \
meth_desc1 {1/{exbrate}} meth_desc2 0 meth_desc3 3
call /inputs/{mfincomp}/ex_tt TABFILL
// Next line takes baseline_rate back to near-zero.
call /inputs/{mfincomp}/ex_tt TUPDATE 2 0 {exbonset} {10000}
create spikegen /inputs/{mfincomp}/ex_spikegen
setfield /inputs/{mfincomp}/ex_spikegen output_amp 1 thresh 0.5
addmsg /inputs/{mfincomp}/ex_tt /inputs/{mfincomp}/ex_spikegen INPUT activation
addmsg /inputs/{mfincomp}/ex_spikegen {mfincomp}/AMPAd SPIKE
end
end
closefile {MF_infile}
end
randseed {nextseed}
nextseed = {rand 100000 999999}
if (inb1dur > 0)
openfile {PC_infile} r
for (i = 1; i <= {no_PC}; i = i + 1)
pcincomp = {readfile {PC_infile}}
if (inhib_rate_d > 0)
if(inb1rate > 0)
call /inputs/{pcincomp}/inhib_tt TUPDATE 2 {inb1onset} {{inb1onset} + {inb1dur}} {1.0 / {inb1rate}}
end
randseed {nextseed}
nextseed = {rand 100000 999999}
if(inb2dur > 0)
call /inputs/{pcincomp}/inhib_tt TUPDATE 2 {{inb1onset}+{inb1dur}} {{inb1onset}+{inb1dur}+{inb2dur}} {1.0 / {{inb2fac} * {inhib_rate_d}}}
end
randseed {nextseed}
nextseed = {rand 100000 999999}
else
if(inb1rate > 0)
if(!{exists /inputs/{pcincomp}})
create neutral /inputs/{pcincomp}
end
create timetable /inputs/{pcincomp}/inhib_tt
setfield /inputs/{pcincomp}/inhib_tt \
maxtime {{inb1onset} + {inb1dur}} act_val 1.0 method 2 \
meth_desc1 {1/{inb1rate}} meth_desc2 0 meth_desc3 3
call /inputs/{pcincomp}/inhib_tt TABFILL
if(inb2dur > 0)
call /inputs/{pcincomp}/inhib_tt TUPDATE 2 {{inb1onset} + {inb1dur}} {{inb1onset} + {inb1dur} + {inb2dur}} {1.0 / {{inb2fac} * {inhib_rate_d}}}
end
randseed {nextseed}
nextseed = {rand 100000 999999}
// Next line takes baseline_rate back to near-zero.
call /inputs/{pcincomp}/inhib_tt TUPDATE 2 0 {inb1onset} {10000}
create spikegen /inputs/{pcincomp}/inhib_spikegen
setfield /inputs/{pcincomp}/inhib_spikegen output_amp 1 thresh 0.5
addmsg /inputs/{pcincomp}/inhib_tt /inputs/{pcincomp}/inhib_spikegen INPUT activation
addmsg /inputs/{pcincomp}/inhib_spikegen {pcincomp}/GABAd SPIKE
end
end
end
closefile {PC_infile}
end
silent -1
end