From 09259ad5bb1fb065267a7b80ed442a3729fb4646 Mon Sep 17 00:00:00 2001 From: jkgoodrich <33063077+jkgoodrich@users.noreply.github.com> Date: Mon, 8 Apr 2024 11:14:08 -0600 Subject: [PATCH] feat(frontend): add help topic for combined frequency stats (#1465) Co-authored-by: Katherine Chao --- browser/help/helpPageTableOfContents.ts | 1 + browser/help/topics/cmh-pval.png | Bin 0 -> 102828 bytes browser/help/topics/combined-freq-stats.md | 28 ++++++++++++++++++ .../help/__snapshots__/HelpPage.spec.tsx.snap | 20 +++++++++++++ 4 files changed, 49 insertions(+) create mode 100644 browser/help/topics/cmh-pval.png create mode 100644 browser/help/topics/combined-freq-stats.md diff --git a/browser/help/helpPageTableOfContents.ts b/browser/help/helpPageTableOfContents.ts index 50e85a919..faae13ac8 100644 --- a/browser/help/helpPageTableOfContents.ts +++ b/browser/help/helpPageTableOfContents.ts @@ -20,6 +20,7 @@ const helpPageTableOfContents: { topics: string[]; faq: FaqTopic[] } = { 'hgdp-1kg-annotations', 'v4-hts', 'exome-capture-tech', + 'combined-freq-stats', ], faq: [ { diff --git a/browser/help/topics/cmh-pval.png b/browser/help/topics/cmh-pval.png new file mode 100644 index 0000000000000000000000000000000000000000..595171d042a7dd94f96f99d7c681488250a2145a GIT binary patch literal 102828 zcmeFZcUV+Q(+5Zx29N=UJV*`_M3Q6}G7KPDR78**B_{=mLmXsaM3KyZfFOdPf(l3& zvScKPAUWrp;~wt&Uhm!S+udjX-~EH5TF6@%Z=(5GA}^!}_nz zN}rWHOc-qG^Wo;WS1%r9K=Ll|JRf^08mxvq+Mp3TRorcBj|dJ8i|ue@_^ z7~6CAlUzzmQa8k>f)v4&)eNBchRRSP(ic=j*GN=hFrKlH8i#eMfq^>*YfM${2Wtm# z{jp`!pyh~zjCbe33v#}XEZ>r}vE!3!DiKgW4+U}m{it*`5&6%rKOY20_+G4${-6Hy z@*C2M;F;~Wu>aM-G9{FAxa4n|f2dHyc(OIW2>j1JLqSob0QoEbKl%SpO-}zcj=$vZ zOw00Ud(Nrt#Wkm`>E@UoF^6uQGW)Ju;ozl>ZJ zXhb}$(DCKES`}gMhWqrni_&7dC8@Y2qFEl_9|3;d47*33-8LQhozif1pf1LV=$K^s zFks@uTy`$es4tvSA%zAj_ry(hKERrKyr zPl$p(P5#8*EhTnbxN<5H8GYXSuj8^Tz5|9V!U{o|&M(NZGoIdzWzP_vRujCkmQ|0(Zje+DKzcbvRJrR;=Y)GOj(3Q7gI@W;S$oNi z-ZP5l!clhX-hbzTQI3z#Qh 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zI*ZDFkW7^T-$`$W9B1=i?W~(?-T7fKKNu)pD9Jc#WMFtVI2cM(%~aLq0=j6*kR3JG zTFX&!2g}X@cfDo@=M@GI#{P|;F2;TbrD*waI3$oTJ zKjJI5%5+x + +**Why have we added these statistical tests** + +For the first time, in gnomAD v4.0, we released a combined filtering allele frequency (FAF), integrating variant frequencies across the 734,947 exomes and 76,215 genomes. This integration brings the advantage of a larger, more diverse sample set but also introduces challenges. These challenges stem from differences in sequencing and processing methodologies, as well as variations in sample composition due to ascertainment biases. Addressing these challenges is crucial for providing accurate and reliable genetic insights. + +These enhancements and warnings are part of our ongoing commitment to data integrity and usability in gnomAD. By identifying variants with significant frequency discrepancies and providing contextual warnings, we aim to equip researchers with the knowledge needed to make informed decisions in their genetic analyses. We encourage users to explore these new statistical analyses as they navigate gnomAD v4.1. + +For more information about these flags and how to approach interpreting frequencies at the flagged loci, please see our [blog post](https://gnomad.broadinstitute.org/news/2024-04-gnomad-v4-1). diff --git a/browser/src/help/__snapshots__/HelpPage.spec.tsx.snap b/browser/src/help/__snapshots__/HelpPage.spec.tsx.snap index 194a3523b..7c8c9357c 100644 --- a/browser/src/help/__snapshots__/HelpPage.spec.tsx.snap +++ b/browser/src/help/__snapshots__/HelpPage.spec.tsx.snap @@ -769,6 +769,15 @@ exports[`Help Page has no unexpected changes 1`] = ` exome-capture-tech +
  • + + combined-freq-stats + +
  • +
  • + + combined-freq-stats + +