diff --git a/packages/react-native/ReactCommon/hermes/inspector/Inspector.h b/packages/react-native/ReactCommon/hermes/inspector/Inspector.h
index 672bfad6b4a0ff..0f6a3ed0503ded 100644
--- a/packages/react-native/ReactCommon/hermes/inspector/Inspector.h
+++ b/packages/react-native/ReactCommon/hermes/inspector/Inspector.h
@@ -372,6 +372,10 @@ std::optional<UserCallbackException> runUserCallback(C &cb, A &&...arg) {
     cb(std::forward<A>(arg)...);
   } catch (const std::exception &e) {
     return UserCallbackException(e);
+  } catch (const std::runtime_error &e) {
+    // NOTE(kudo): Adding this to catch Hermes inspector exceptions after SDK 49.
+    // I still not figure out why the std::runtime_error is not catched by the std::exception above.
+    return UserCallbackException(e);
   }
 
   return {};