diff --git a/NEWS.md b/NEWS.md
index 425545ac..bce33f5f 100644
--- a/NEWS.md
+++ b/NEWS.md
@@ -1,3 +1,28 @@
+Release 2.22-r1101 (7 August 2021)
+----------------------------------
+
+When choosing the best alignment, this release uses logarithm gap penalty and
+query-specific mismatch penalty. It improves the sensitivity to long INDELs in
+repetitive regions.
+
+Other notable changes:
+
+ * Bugfix: fixed an indirect memory leak that may waste a large amount of
+   memory given highly repetitive reference such as a 16S RNA database (#749).
+   All versions of minimap2 have this issue.
+
+ * New feature: added --cap-kalloc to reduce the peak memory. This option is
+   not enabled by default but may become the default in future releases.
+
+Known issue:
+
+ * Minimap2 may take a long time to map a read (#771). So far it is not clear
+   if this happens to v2.18 and earlier versions.
+
+(2.22: 7 August 2021, r1101)
+
+
+
 Release 2.21-r1071 (6 July 2021)
 --------------------------------
 
@@ -5,7 +30,7 @@ This release fixed a regression in short-read mapping introduced in v2.19
 (#776). It also fixed invalid comparisons of uninitialized variables, though
 these are harmless (#752). Long-read alignment should be identical to v2.20.
 
-(2.21: 6 July 2021)
+(2.21: 6 July 2021, r1071)
 
 
 
diff --git a/README.md b/README.md
index 0bff2e48..90af2829 100644
--- a/README.md
+++ b/README.md
@@ -74,8 +74,8 @@ Detailed evaluations are available from the [minimap2 paper][doi] or the
 Minimap2 is optimized for x86-64 CPUs. You can acquire precompiled binaries from
 the [release page][release] with:
 ```sh
-curl -L https://github.com/lh3/minimap2/releases/download/v2.21/minimap2-2.21_x64-linux.tar.bz2 | tar -jxvf -
-./minimap2-2.21_x64-linux/minimap2
+curl -L https://github.com/lh3/minimap2/releases/download/v2.22/minimap2-2.22_x64-linux.tar.bz2 | tar -jxvf -
+./minimap2-2.22_x64-linux/minimap2
 ```
 If you want to compile from the source, you need to have a C compiler, GNU make
 and zlib development files installed. Then type `make` in the source code
diff --git a/cookbook.md b/cookbook.md
index 8df1e28d..14c4dfac 100644
--- a/cookbook.md
+++ b/cookbook.md
@@ -31,8 +31,8 @@ To acquire the data used in this cookbook and to install minimap2 and paftools,
 please follow the command lines below:
 ```sh
 # install minimap2 executables
-curl -L https://github.com/lh3/minimap2/releases/download/v2.21/minimap2-2.21_x64-linux.tar.bz2 | tar jxf -
-cp minimap2-2.21_x64-linux/{minimap2,k8,paftools.js} .  # copy executables
+curl -L https://github.com/lh3/minimap2/releases/download/v2.22/minimap2-2.22_x64-linux.tar.bz2 | tar jxf -
+cp minimap2-2.22_x64-linux/{minimap2,k8,paftools.js} .  # copy executables
 export PATH="$PATH:"`pwd`                               # put the current directory on PATH
 # download example datasets
 curl -L https://github.com/lh3/minimap2/releases/download/v2.10/cookbook-data.tgz | tar zxf -
diff --git a/main.c b/main.c
index 0c13ab17..3c625760 100644
--- a/main.c
+++ b/main.c
@@ -7,7 +7,7 @@
 #include "mmpriv.h"
 #include "ketopt.h"
 
-#define MM_VERSION "2.21-dev-r1094-dirty"
+#define MM_VERSION "2.22-r1101"
 
 #ifdef __linux__
 #include <sys/resource.h>
diff --git a/minimap2.1 b/minimap2.1
index 96dd4220..86454716 100644
--- a/minimap2.1
+++ b/minimap2.1
@@ -1,4 +1,4 @@
-.TH minimap2 1 "6 July 2021" "minimap2-2.21 (r1071)" "Bioinformatics tools"
+.TH minimap2 1 "7 August 2021" "minimap2-2.22 (r1101)" "Bioinformatics tools"
 .SH NAME
 .PP
 minimap2 - mapping and alignment between collections of DNA sequences
@@ -423,6 +423,11 @@ alignment.
 Skip alignment if the DP matrix size is above
 .IR NUM .
 Set 0 to disable [100m].
+.TP
+.BI --cap-kalloc \ NUM
+Free thread-local kalloc memory reservoir if after the alignment the size of the reservoir above
+.IR NUM .
+Set 0 to disable [0].
 .SS Input/output options
 .TP 10
 .B -a
diff --git a/misc/paftools.js b/misc/paftools.js
index 11d77222..420cbd60 100755
--- a/misc/paftools.js
+++ b/misc/paftools.js
@@ -1,6 +1,6 @@
 #!/usr/bin/env k8
 
-var paftools_version = '2.21-r1071';
+var paftools_version = '2.22-r1101';
 
 /*****************************
  ***** Library functions *****
diff --git a/python/cmappy.pxd b/python/cmappy.pxd
index abc3ef7c..b3016746 100644
--- a/python/cmappy.pxd
+++ b/python/cmappy.pxd
@@ -45,6 +45,9 @@ cdef extern from "minimap.h":
 		int anchor_ext_len, anchor_ext_shift
 		float max_clip_ratio
 
+		int rank_min_len
+		float rank_frac
+
 		int pe_ori, pe_bonus
 
 		float mid_occ_frac
@@ -53,6 +56,7 @@ cdef extern from "minimap.h":
 		int32_t max_occ
 		int64_t mini_batch_size
 		int64_t max_sw_mat
+		int64_t cap_kalloc
 
 		const char *split_prefix
 
diff --git a/python/mappy.pyx b/python/mappy.pyx
index 838b5ad0..8728a3e4 100644
--- a/python/mappy.pyx
+++ b/python/mappy.pyx
@@ -3,7 +3,7 @@ from libc.stdlib cimport free
 cimport cmappy
 import sys
 
-__version__ = '2.21'
+__version__ = '2.22'
 
 cmappy.mm_reset_timer()
 
diff --git a/setup.py b/setup.py
index 1a4d2277..38762a85 100644
--- a/setup.py
+++ b/setup.py
@@ -23,7 +23,7 @@ def readme():
 
 setup(
 	name = 'mappy',
-	version = '2.21',
+	version = '2.22',
 	url = 'https://github.com/lh3/minimap2',
 	description = 'Minimap2 python binding',
 	long_description = readme(),