v5.0.0-rc

New release candidate release 5.0.0-rc

Release v4.9.6

• Fixed small edge case in which the wrong ClinVar accession was returned when two variants were annotated at the same time and had the same coordinates.
• Fixed HGVSp bug where certain variants threw an exception

Release v4.9.5

Fixed bug which caused some ClinVar accessions not to be returned in certain queries.

Release v4.9.4

• no HGVS is calculated for symbolic variants.
• Transcript HGVS no longer fails for long insertions.
• No HGVSp is calculated for insertions falling on an incomplete first codon.

See #550

Release v4.9.3

Demoted log message to DEBUG from INFO

Release v4.9.2

Another HGVSp fix
See #548

v4.9.0

• Increase Cellbase threshold for indels annotation from 50bp
• updated the parser to parse the latest Clinvar file format (2021-01).
• HGVSp - update to handle more cases
• MNVs - fixed off-by-one error

v4.8.1

New stable release 4.8.1

v4.8.0

• Protein HGVS is now returned as part of the CellBase VariantAnnotation payload
• Protein-level variation is now checked when annotating clinical variant data, i.e. when annotating variants with ClinVar, COSMIC, DOCM & IARCTP53 data. (simply activate checkAminoAcidChange on variants/{variant}/annotation requests)
• ClinVar SCVs are now also provided as part of ClinVar data
• Both ClinVar and COSMIC parsers updated to ClinVar Feb 2020 and COSMIC v90 versions

v4.7.1

• Bugfix on samples data order not matching input VCF order after annotation