diff --git a/.github/workflows/merge-pytest.yml b/.github/workflows/merge-pytest.yml
index e52090686..ba20df97e 100644
--- a/.github/workflows/merge-pytest.yml
+++ b/.github/workflows/merge-pytest.yml
@@ -51,26 +51,13 @@ jobs:
         id: setup-python
         with:
           python-version: ${{ matrix.python-version }}
-      - name: Install poetry
-        uses: snok/install-poetry@v1
-        with:
-          virtualenvs-create: true
-          virtualenvs-in-project: true
-          installer-parallel: true
-      - name: Load cached venv
-        id: cached-poetry-dependencies
-        uses: actions/cache@v4
-        with:
-          path: .venv
-          key: venv-${{ runner.os }}-${{ steps.setup-python.outputs.python-version }}-${{ hashFiles('**/poetry.lock') }}
       - name: Install dependencies
-        run: poetry install --no-interaction --extras tests
+        run: pip install .[tests]
       - name: Test with pytest
         env:
           PYTHON_VERSION: ${{ matrix.python-version }}
         run: |
-          poetry run pytest --cov pynetdicom --ignore=pynetdicom/apps &&
-          poetry run coverage xml
+          pytest --cov pynetdicom --ignore=pynetdicom/apps && coverage xml
       - name: Send coverage results
         if: success()
         uses: codecov/codecov-action@v4
@@ -95,20 +82,8 @@ jobs:
       id: setup-python
       with:
         python-version: ${{ matrix.python-version }}
-    - name: Install poetry
-      uses: snok/install-poetry@v1
-      with:
-        virtualenvs-create: true
-        virtualenvs-in-project: true
-        installer-parallel: true
-    - name: Load cached venv
-      id: cached-poetry-dependencies
-      uses: actions/cache@v4
-      with:
-        path: .venv
-        key: venv-${{ runner.os }}-${{ steps.setup-python.outputs.python-version }}-${{ hashFiles('**/poetry.lock') }}
     - name: Install dependencies
-      run: poetry install --no-interaction --extras tests
+      run: pip install .[tests]
     - name: Switch to development pydicom
       run: |
         pip install git+https://github.com/pydicom/pydicom
@@ -116,8 +91,7 @@ jobs:
       env:
         PYTHON_VERSION: ${{ matrix.python-version }}
       run: |
-        poetry run pytest --cov pynetdicom --ignore=pynetdicom/apps &&
-        poetry run coverage xml
+        pytest --cov pynetdicom --ignore=pynetdicom/apps && coverage xml
     - name: Send coverage results
       if: success()
       uses: codecov/codecov-action@v4
@@ -142,28 +116,14 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: ${{ matrix.python-version }}
-    - name: Install poetry
-      uses: snok/install-poetry@v1
-      with:
-        virtualenvs-create: true
-        virtualenvs-in-project: true
-        installer-parallel: true
-    - name: Load cached venv
-      id: cached-poetry-dependencies
-      uses: actions/cache@v4
-      with:
-        path: .venv
-        key: venv-${{ runner.os }}-${{ steps.setup-python.outputs.python-version }}-${{ hashFiles('**/poetry.lock') }}
     - name: Install dependencies
       run: |
-        poetry install --no-interaction --extras tests &&
-        poetry run pip list
+        pip install -e .[tests]
     - name: Test with pytest
       env:
         PYTHON_VERSION: ${{ matrix.python-version }}
       run: |
-        poetry run pytest --cov pynetdicom --ignore=pynetdicom/apps &&
-        poetry run coverage xml
+        pytest --cov pynetdicom --ignore=pynetdicom/apps && coverage xml
     - name: Send coverage results
       if: success()
       uses: codecov/codecov-action@v4
diff --git a/.github/workflows/merge-typing.yml b/.github/workflows/merge-typing.yml
index d759fa5b8..28291c07e 100644
--- a/.github/workflows/merge-typing.yml
+++ b/.github/workflows/merge-typing.yml
@@ -21,20 +21,8 @@ jobs:
       id: setup-python
       with:
         python-version: ${{ matrix.python-version }}
-    - name: Install poetry
-      uses: snok/install-poetry@v1
-      with:
-        virtualenvs-create: true
-        virtualenvs-in-project: true
-        installer-parallel: true
-    - name: Load cached venv
-      id: cached-poetry-dependencies
-      uses: actions/cache@v4
-      with:
-        path: .venv
-        key: venv-${{ runner.os }}-${{ steps.setup-python.outputs.python-version }}-${{ hashFiles('**/poetry.lock') }}
     - name: Install dependencies
-      run: poetry install --no-interaction --no-root --extras dev
+      run: pip install .[dev]
     - name: Run typing check with mypy
       run: |
-        poetry run mypy
+        mypy
diff --git a/.github/workflows/pr-pytest-apps.yml b/.github/workflows/pr-pytest-apps.yml
index e73942843..5ca8b932e 100644
--- a/.github/workflows/pr-pytest-apps.yml
+++ b/.github/workflows/pr-pytest-apps.yml
@@ -23,29 +23,16 @@ jobs:
       id: setup-python
       with:
         python-version: ${{ matrix.python-version }}
-    - name: Install poetry
-      uses: snok/install-poetry@v1
-      with:
-        virtualenvs-create: true
-        virtualenvs-in-project: true
-        installer-parallel: true
-    - name: Load cached venv
-      id: cached-poetry-dependencies
-      uses: actions/cache@v4
-      with:
-        path: .venv
-        key: venv-${{ runner.os }}-${{ steps.setup-python.outputs.python-version }}-${{ hashFiles('**/poetry.lock') }}
     - name: Install dependencies
-      run: poetry install --no-interaction --extras tests
+      run: pip install -e .[tests]
     - name: Switch to development pydicom
       run: |
-        pip install git+https://github.com/pydicom/pydicom &&
-        poetry run pip list
+        pip install git+https://github.com/pydicom/pydicom
     - name: Test with pytest
       env:
         PYTHON_VERSION: ${{ matrix.python-version }}
       run: |
-        poetry run pytest -x --ignore=pynetdicom/tests
+        pytest -x --ignore=pynetdicom/tests
 
   # pydicom-release:
   #   runs-on: ubuntu-latest
diff --git a/.github/workflows/pr-pytest.yml b/.github/workflows/pr-pytest.yml
index 3c4eb68e0..2606e64eb 100644
--- a/.github/workflows/pr-pytest.yml
+++ b/.github/workflows/pr-pytest.yml
@@ -54,29 +54,16 @@ jobs:
         id: setup-python
         with:
           python-version: ${{ matrix.python-version }}
-      - name: Install poetry
-        uses: snok/install-poetry@v1
-        with:
-          virtualenvs-create: true
-          virtualenvs-in-project: true
-          installer-parallel: true
-      - name: Load cached venv
-        id: cached-poetry-dependencies
-        uses: actions/cache@v4
-        with:
-          path: .venv
-          key: venv-${{ runner.os }}-${{ steps.setup-python.outputs.python-version }}-${{ hashFiles('**/poetry.lock') }}
       - name: Install dependencies
-        run: poetry install --no-interaction --extras tests
+        run: pip install -e .[tests]
       - name: Get OpenSSL version
         run: |
-          poetry run python -c "import ssl; print('OpenSSL:', ssl.OPENSSL_VERSION_INFO)"
+          python -c "import ssl; print('OpenSSL:', ssl.OPENSSL_VERSION_INFO)"
       - name: Test with pytest
         env:
           PYTHON_VERSION: ${{ matrix.python-version }}
         run: |
-          poetry run pytest -x --cov pynetdicom --ignore=pynetdicom/apps &&
-          poetry run coverage xml
+          pytest -x --cov pynetdicom --ignore=pynetdicom/apps && coverage xml
       - name: Send coverage results
         if: ${{ success() }}
         uses: codecov/codecov-action@v4
@@ -99,20 +86,8 @@ jobs:
       id: setup-python
       with:
         python-version: ${{ matrix.python-version }}
-    - name: Install poetry
-      uses: snok/install-poetry@v1
-      with:
-        virtualenvs-create: true
-        virtualenvs-in-project: true
-        installer-parallel: true
-    - name: Load cached venv
-      id: cached-poetry-dependencies
-      uses: actions/cache@v4
-      with:
-        path: .venv
-        key: venv-${{ runner.os }}-${{ steps.setup-python.outputs.python-version }}-${{ hashFiles('**/poetry.lock') }}
     - name: Install dependencies
-      run: poetry install --no-interaction --extras tests
+      run: pip install -e .[tests]
     - name: Switch to development pydicom
       run: |
         pip install git+https://github.com/pydicom/pydicom
@@ -120,8 +95,7 @@ jobs:
       env:
         PYTHON_VERSION: ${{ matrix.python-version }}
       run: |
-        poetry run pytest -x --cov pynetdicom --ignore=pynetdicom/apps &&
-        poetry run coverage xml
+        pytest -x --cov pynetdicom --ignore=pynetdicom/apps && coverage xml
     - name: Send coverage results
       if: ${{ success() }}
       uses: codecov/codecov-action@v4
@@ -144,31 +118,17 @@ jobs:
       uses: actions/setup-python@v5
       with:
         python-version: ${{ matrix.python-version }}
-    - name: Install poetry
-      uses: snok/install-poetry@v1
-      with:
-        virtualenvs-create: true
-        virtualenvs-in-project: true
-        installer-parallel: true
-    - name: Load cached venv
-      id: cached-poetry-dependencies
-      uses: actions/cache@v4
-      with:
-        path: .venv
-        key: venv-${{ runner.os }}-${{ steps.setup-python.outputs.python-version }}-${{ hashFiles('**/poetry.lock') }}
     - name: Install dependencies
       run: |
-        poetry install --no-interaction --extras tests &&
-        poetry run pip list
+        pip install -e .[tests]
     - name: Get OpenSSL version
       run: |
-        poetry run python -c "import ssl; print('OpenSSL:', ssl.OPENSSL_VERSION_INFO)"
+        python -c "import ssl; print('OpenSSL:', ssl.OPENSSL_VERSION_INFO)"
     - name: Test with pytest
       env:
         PYTHON_VERSION: ${{ matrix.python-version }}
       run: |
-        poetry run pytest -x --cov pynetdicom --ignore=pynetdicom/apps &&
-        poetry run coverage xml
+        pytest -x --cov pynetdicom --ignore=pynetdicom/apps && coverage xml
     - name: Send coverage results
       if: ${{ success() }}
       uses: codecov/codecov-action@v4
diff --git a/.github/workflows/pr-type-lint-format.yml b/.github/workflows/pr-type-lint-format.yml
index 3cbda228d..21a166a33 100644
--- a/.github/workflows/pr-type-lint-format.yml
+++ b/.github/workflows/pr-type-lint-format.yml
@@ -21,29 +21,17 @@ jobs:
       id: setup-python
       with:
         python-version: ${{ matrix.python-version }}
-    - name: Install poetry
-      uses: snok/install-poetry@v1
-      with:
-        virtualenvs-create: true
-        virtualenvs-in-project: true
-        installer-parallel: true
-    - name: Load cached venv
-      id: cached-poetry-dependencies
-      uses: actions/cache@v4
-      with:
-        path: .venv
-        key: venv-${{ runner.os }}-${{ steps.setup-python.outputs.python-version }}-${{ hashFiles('**/poetry.lock') }}
     - name: Install dependencies
-      run: poetry install --no-interaction --no-root --extras dev
+      run: pip install -e .[dev]
     - name: Run type check using mypy
       run: |
-        poetry run mypy
+        mypy
     - name: Run formatting check using black
       run: |
-        poetry run black . --check
+        black . --check
     - name : Run linting check using ruff
       run: |
-        poetry run ruff check .
+        ruff check .
     - name: Run spell check using codespell
       run: |
-        poetry run codespell -d pynetdicom
+        codespell -d pynetdicom
diff --git a/.github/workflows/publish-pypi-deploy.yml b/.github/workflows/publish-pypi-deploy.yml
index cdaf0931f..b9c66a76c 100644
--- a/.github/workflows/publish-pypi-deploy.yml
+++ b/.github/workflows/publish-pypi-deploy.yml
@@ -18,16 +18,13 @@ jobs:
       with:
         python-version: '3.10'
 
-    - name: Install poetry
-      uses: snok/install-poetry@v1
-      with:
-        virtualenvs-create: true
-        virtualenvs-in-project: true
-        installer-parallel: true
+    - name: Install flit
+      run: |
+        pip install -U flit
 
     - name: Build package
       run: |
-        poetry build
+        flit build
 
     - name: Upload artifacts
       if: ${{ success() }}
@@ -42,7 +39,7 @@ jobs:
     runs-on: ubuntu-latest
     environment:
       name: pypi
-      url: https://pypi.org/project/pylibjpeg-libjpeg/
+      url: https://pypi.org/project/pynetdicom/
     permissions:
       id-token: write
 
diff --git a/pyproject.toml b/pyproject.toml
index e748e3c6e..be6803d16 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -23,13 +23,13 @@ classifiers=[
 ]
 description = "A Python implementation of the DICOM networking protocol"
 keywords = ["dicom", "networking", "pydicom"]
-license = {file = "LICENSE"}
+license = {file = "LICENCE"}
 maintainers = [
     {name = "scaramallion", email = "scaramallion@users.noreply.github.com"},
 ]
 name = "pynetdicom"
 readme = "README.rst"
-version = "2.1.1"
+version = "2.2.0.dev0"
 requires-python = ">=3.10"
 dependencies = ["pydicom >=2.4"]
 
@@ -77,13 +77,6 @@ qrscp = "pynetdicom.apps.qrscp.qrscp:main"
 storescp = "pynetdicom.apps.storescp.storescp:main"
 storescu = "pynetdicom.apps.storescu.storescu:main"
 
-# [tool.flit.sdist]
-# include = [
-#     "pynetdicom/tests/cert_files/*",
-#     "pynetdicom/tests/dicom_files/*",
-#     "pynetdicom/apps/qrscp/default.ini",
-# ]
-
 
 [tool.black]
 exclude = ".venv*|env*|build|/_.*_dict.py$"