diff --git a/AUTHORS b/AUTHORS
index d1a2d3e7911..d1c2edd85fb 100644
--- a/AUTHORS
+++ b/AUTHORS
@@ -483,6 +483,7 @@ Terje Runde
 Thomas Grainger
 Thomas Hisch
 Tianyu Dongfang
+Tim Anderson
 Tim Hoffmann
 Tim Strazny
 TJ Bruno
diff --git a/changelog/14942.bugfix.rst b/changelog/14942.bugfix.rst
new file mode 100644
index 00000000000..3f1fd6e4f43
--- /dev/null
+++ b/changelog/14942.bugfix.rst
@@ -0,0 +1,2 @@
+Fixed quadratic fixture-registration behavior when many unrelated collection
+nodes define fixtures with the same name.
diff --git a/src/_pytest/fixtures.py b/src/_pytest/fixtures.py
index 05537ec01b2..84aac0a67b4 100644
--- a/src/_pytest/fixtures.py
+++ b/src/_pytest/fixtures.py
@@ -1792,6 +1792,17 @@ def __init__(self, session: Session) -> None:
         # TODO: The order of the FixtureDefs list of each arg is significant,
         #       explain.
         self._arg2fixturedefs: Final[dict[str, list[FixtureDef[Any]]]] = {}
+        # Maps a fixture name to nodes which are strict ancestors of at least
+        # one node where a fixture with that name is registered. This lets the
+        # overwhelmingly common case (fixtures on unrelated sibling nodes) be
+        # appended without scanning the entire override chain.
+        self._arg2fixturedefs_ancestor_nodes: Final[dict[str, set[nodes.Node]]] = (
+            defaultdict(set)
+        )
+        # Fixture definitions using the deprecated string-nodeid API cannot
+        # participate in the node index above, so names containing one retain
+        # the complete comparison path.
+        self._arg2fixturedefs_with_legacy_visibility: Final[set[str]] = set()
         # A mapping from a node to a list of autouse fixture names it defines.
         # The Session entry holds global usefixtures from config.
         self._node_autousenames: Final[dict[nodes.Node, list[str]]] = {
@@ -2107,12 +2118,27 @@ def _register_fixture(
         # cannot be visible together.
         # The idea is that a fixture that is defined closer to the item should
         # take precedence.
-        for i, existing in enumerate(faclist):
-            if is_visibility_more_specific(existing, fixture_def):
-                faclist.insert(i, fixture_def)
-                break
-        else:
+        ancestor_nodes = self._arg2fixturedefs_ancestor_nodes[name]
+        if (
+            fixture_def.node is not None
+            and name not in self._arg2fixturedefs_with_legacy_visibility
+            and fixture_def.node not in ancestor_nodes
+        ):
             faclist.append(fixture_def)
+        else:
+            for i, existing in enumerate(faclist):
+                if is_visibility_more_specific(existing, fixture_def):
+                    faclist.insert(i, fixture_def)
+                    break
+            else:
+                faclist.append(fixture_def)
+
+        if fixture_def.node is not None:
+            parents = fixture_def.node.iter_parents()
+            next(parents)  # The fixture's own node is not a strict ancestor.
+            ancestor_nodes.update(parents)
+        else:
+            self._arg2fixturedefs_with_legacy_visibility.add(name)
         if autouse:
             if node is not NOTSET:
                 self._node_autousenames.setdefault(node, []).append(name)
diff --git a/testing/python/fixtures.py b/testing/python/fixtures.py
index e4334af2145..2331a73da4b 100644
--- a/testing/python/fixtures.py
+++ b/testing/python/fixtures.py
@@ -1950,6 +1950,53 @@ def test(fix):
         reprec = pytester.inline_run()
         reprec.assertoutcome(passed=1)
 
+    def test_register_sibling_fixtures_avoids_quadratic_comparisons(
+        self, pytester: Pytester
+    ) -> None:
+        pytester.makeconftest(
+            """
+            import pytest
+            import _pytest.fixtures
+
+            @pytest.hookimpl(wrapper=True)
+            def pytest_collection():
+                original = _pytest.fixtures.is_visibility_more_specific
+                comparisons = 0
+
+                def counted(candidate, other):
+                    nonlocal comparisons
+                    comparisons += 1
+                    return original(candidate, other)
+
+                _pytest.fixtures.is_visibility_more_specific = counted
+                try:
+                    result = yield
+                finally:
+                    _pytest.fixtures.is_visibility_more_specific = original
+
+                # Sibling class fixtures cannot override one another. Their
+                # registration should not compare every pair (#14942).
+                assert comparisons < 40
+                return result
+            """
+        )
+        classes = "\n".join(
+            f"""class Test{i}:
+    @pytest.fixture
+    def shared(self):
+        return {i}
+
+    def test_shared(self, shared):
+        assert shared == {i}
+"""
+            for i in range(40)
+        )
+        pytester.makepyfile(f"import pytest\n{classes}")
+
+        result = pytester.runpytest()
+
+        result.assert_outcomes(passed=40)
+
     def test_parsefactories_relative_node_ids(
         self, pytester: Pytester, monkeypatch: MonkeyPatch
     ) -> None: