From 02aaf25d7ee7975886caa0cb845f85e52d5a8c15 Mon Sep 17 00:00:00 2001 From: runner Date: Mon, 4 Sep 2023 00:39:40 +0000 Subject: [PATCH] Re-build website --- data/clinical_trials_clean.csv | 127 +++---- data/contact.rds | Bin 10956 -> 10639 bytes data/data_dt.rds | Bin 17363 -> 17061 bytes data/location.rds | Bin 5252 -> 5099 bytes data/study_info.rds | Bin 249677 -> 243598 bytes docs/about.html | 2 +- docs/data/clinical_trials_clean.csv | 127 +++---- docs/data/contact.rds | Bin 10956 -> 10639 bytes docs/data/data_dt.rds | Bin 17363 -> 17061 bytes docs/data/location.rds | Bin 5252 -> 5099 bytes docs/data/study_info.rds | Bin 249677 -> 243598 bytes docs/list_view.html | 346 +++--------------- docs/recent.html | 6 +- docs/remote.html | 6 +- .../datatables.js | 2 +- docs/site_libs/jquery-1.12.4/jquery.min.js | 5 - .../leaflet.js | 24 +- .../site_libs/leafletfix-1.0.0/leafletfix.css | 10 +- docs/uk-europe-map.html | 8 +- docs/us-canada-map.html | 8 +- 20 files changed, 181 insertions(+), 490 deletions(-) rename docs/site_libs/{datatables-binding-0.28 => datatables-binding-0.29}/datatables.js (99%) delete mode 100644 docs/site_libs/jquery-1.12.4/jquery.min.js rename docs/site_libs/{leaflet-binding-2.1.2 => leaflet-binding-2.2.0}/leaflet.js (99%) diff --git a/data/clinical_trials_clean.csv b/data/clinical_trials_clean.csv index a609811..2ba0dd4 100644 --- a/data/clinical_trials_clean.csv +++ b/data/clinical_trials_clean.csv @@ -1093,30 +1093,7 @@ Recurrence of a stroke impacting the reorganisation of neural networks Persons deprived of their liberty by a judicial or administrative decision Persons of legal age under a legal protection measure (guardianship, curatorship) Pregnant women, women in labour or nursing mothers, confirmed by questioning the participant Participation in another study at the same time as this one","Accepts Healthy Volunteers","18 Years","All","Saint-Genis-Laval","69230",NA,NA,"France",1,"no",4.792883,45.695002,2023-05-26 -"44",48,"Combining tDCS and CILT in Non-fluent Aphasia","Aphasia Non-fluent Aphasia Stroke Brain Injuries","April 24, 2023","NCT05561400","University of Minnesota Duluth Minnesota United States","University of Minnesota","Recruiting","The long-term goal of this work is to determine if combining a highly intensive, task-specific behavioral language intervention with modulation of the efferent cerebellar-cortical pathway using transcranial direct current stimulation (tDCS) has a positive influence on discourse, verbal fluency and working memory in individuals with non-fluent aphasia after stroke. And if these changes can be related to neuroplastic change in the cerebellar cortical pathway indirectly measured through neurophysiologic changes using spectral electroencephalogram (EEG). The initial phase includes the proposed pilot study data from which will be used to inform a larger clinical trial. The primary aims of this pilot are to 1) determine the effect of combining cerebellar tDCS with constraint-induced language therapy (CILT) on language as measured by a verbal fluency task and discourse task in a small population and 2) identify the tolerance of the intervention and barriers to participation measured by the adverse events questionnaire that will inform the methodology of a larger study. The secondary aims include estimating the size of the treatment effect on 1) delta percentage in F3, F7 and Fp1 compared to F4, F8, and Fp2 using resting state EEG spectral analysis and coherence, 2) working memory as measured by the score on the n-back test and 3) quality of life as measured by the Stroke Aphasia Quality of Life survey tool. The secondary aims will be used to determine the utility of these measures in a larger clinical trial. - -This is a prospective, crossover study, sham-controlled intervention study with two intervention conditions delivered across 6 intervention sessions (3x/week for two weeks) with a 4-week washout in between. Conditions include: 1) sham cerebellar tDCS and 2) real cerebellar tDCS delivered at 2mA across 20 minutes. Each of these will be delivered during CILT intervention with a licensed, certified speech-language pathologist trained in CILT. Once tDCS stimulation has ended, CILT will continue to be delivered for an additional 25 minutes. Assessments of discourse, verbal fluency, working memory and EEG spectral analysis will be conducted at four timepoints, before and after each intervention phase.","This is a prospective sham-controlled, cross-over design. Eligible participants must be over the age of 18 years, be > least 6 months post unilateral cortical stroke and diagnosed with mild to moderate non-fluent aphasia. Additional inclusion/exclusionary criteria have been specified in and approved by the IRB. Six to seven participants are expected to be recruited and screened, with the goal to enroll and complete the study with four individuals who will be randomly assigned to receive either sham or real condition first. The two intervention conditions include: 1) andodal tDCS (2mA) to the right posterior-lateral cerebellum and 2) sham tDCS to the right posterior-lateral cerebellum. The participants will receive 20 minutes of tDCS (sham or real) during CILT followed by an additional 25 minutes of CILT alone. Each condition will be administered 3 days per week for two weeks for a total of 6 intervention sessions with a 4-week washout period between. - -For tDCS (TCT-Research Version tDCS Stimulator, Hong Kong), two 5x5 saline-soaked sponge electrodes will be used with the anode placed over the right cerebellar hemisphere; 1cm under and 4cm lateral of the inion targeting the posterior lateral cerebellum and the cathode will be placed on the right shoulder. The electrode placement will be the same across both conditions. The CILT behavioral intervention will be led by a certified, licensed speech-language pathologist and a graduate student researcher and will follow the guidelines of CILT.","transcranial direct current stimulation (tDCS) non-invasive brain stimulation (NIBS) aphasia constraint-induced language therapy (CILT)","Interventional","Inclusion Criteria: - -over the age of 18 years -history of stroke -diagnosed with non-fluent aphasia. -be able to independently understand simple directions, -use some speech to communicate, -have access to reliable transportation (including taxi and/or other transportation services), -fluent in English. - -Exclusion Criteria: - -Pregnancy, -history of seizures, -any metal implants in the body (excluding dental fillings), -history of migraines, -psoriasis or eczema affecting the scalp, -history of a head injury such as a concussion -diagnosis of a mental health or neurological condition/disease.","No","18 Years","All","Duluth","55812","Minnesota",NA,"United States",1,"no",-92.08343,46.8190805,2023-04-24 -"45",49,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"44",48,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1139,7 +1116,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Baltimore","21287","Maryland",NA,"United States",1,"no",-76.6204945,39.3289375,2021-07-18 -"46",49,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Charleston South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"45",48,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Charleston South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1162,7 +1139,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Charleston","29425","South Carolina",NA,"United States",1,"no",-80.10815,32.792398,2021-07-18 -"47",49,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Columbia South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"46",48,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Columbia South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1185,7 +1162,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Columbia","29208","South Carolina",NA,"United States",1,"no",-81.034331,34.000749,2021-07-18 -"48",50,"HD-tDCS for Phonological Impairment in Aphasia","Aphasia Stroke","August 25, 2023","NCT06010030","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). +"47",49,"HD-tDCS for Phonological Impairment in Aphasia","Aphasia Stroke","August 25, 2023","NCT06010030","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). This study will examine the effects of tDCS during speech therapy to further examine which method or methods is best for patient recovery. Patients enrolled in the study will undergo language testing that covers a broad range of language functions. Functional Magnetic Resonance Imaging (fMRI) will be completed before and after speech therapy intervention arms to investigate the neural processes affected by tDCS and speech therapy. @@ -1220,7 +1197,7 @@ Contraindications to MRI such as claustrophobia, implanted electronic devices, M Younger than 18 or older than 85. < 6 months post tumor resection.","No","18 Years","All","Milwaukee","53226","Wisconsin","Sara Pillay","United States",1,"no",-88.022002,43.04338,2023-08-25 -"49",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Aachen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"48",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Aachen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1245,7 +1222,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Aachen","52074",NA,NA,"Germany",1,"no",6.083862,50.776351,2019-12-06 -"50",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Allensbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"49",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Allensbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1270,7 +1247,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Allensbach","78476",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"51",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Aibling NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"50",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Aibling NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1295,7 +1272,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Aibling","83209",NA,NA,"Germany",1,"no",12.009768,47.86405,2019-12-06 -"52",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Homburg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"51",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Homburg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1320,7 +1297,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Homburg","61348",NA,NA,"Germany",1,"no",8.618313,50.228032,2019-12-06 -"53",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Klosterlausnitz NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"52",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Klosterlausnitz NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1345,7 +1322,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Klosterlausnitz","07639",NA,NA,"Germany",1,"no",11.86817,50.916262,2019-12-06 -"54",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Sülze NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"53",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Sülze NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1370,7 +1347,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Sülze","18334",NA,NA,"Germany",1,"no",12.658113,54.111965,2019-12-06 -"55",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Berlin NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"54",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Berlin NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1395,7 +1372,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Berlin","10115",NA,NA,"Germany",1,"no",13.3888599,52.5170365,2019-12-06 -"56",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Gailingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"55",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Gailingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1420,7 +1397,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Gailingen","78262",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"57",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"56",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1445,7 +1422,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Greifswald","17475",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"58",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"57",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1470,7 +1447,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Greifswald","17491",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"59",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Göppingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"58",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Göppingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1495,7 +1472,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Göppingen","73035",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"60",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Heidelberg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"59",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Heidelberg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1520,7 +1497,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Heidelberg","69117",NA,NA,"Germany",1,"no",8.7112746,49.4121677,2019-12-06 -"61",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Kempen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"60",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Kempen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1545,7 +1522,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Kempen","47906",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"62",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Leipzig NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"61",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Leipzig NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1570,7 +1547,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Leipzig","04103",NA,NA,"Germany",1,"no",12.374733,51.340632,2019-12-06 -"63",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Lindlar NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"62",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Lindlar NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1595,7 +1572,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Lindlar","51789",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"64",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Marbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"63",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Marbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1620,7 +1597,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Marbach","71672",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"65",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Meerbusch NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"64",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Meerbusch NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1645,7 +1622,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Meerbusch","40670",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"66",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Vechta NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"65",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Vechta NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1670,7 +1647,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Vechta","49377",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"67",57,"Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia","Aphasia Apraxia of Speech","December 4, 2018","NCT05248295","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech are most helpful. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? A possible mechanism for this benefit is examined, by testing whether the degree of alignment of a person's speech with that of another speaker can account for unison benefit.","Aphasia is an acquired language disorder, most commonly due to stroke. It can affect an individual's ability to speak, understand spoken language, read, and write. Many treatments designed to improve spoken language in persons with aphasia (PWAs) use unison speech, having the person with aphasia speak along with the clinician or with a recording. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech help them the most. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? This knowledge is important because understanding who benefits from this commonly used and potentially powerful therapy component, under which conditions they benefit, and why they do, is critical for customizing therapy so it can be as effective and efficient as possible. Unison speech is conducted using one of two different timing patterns: (1) a natural conversational pattern, which is used in everyday conversations, or (2) a metrical pattern, which follows a beat-based timing framework, as in songs or some poems. In either case, precisely aligning one's speech with that of another person (i.e., entraining one's speech) requires prediction: each speaker must plan their own speech motor commands before having heard the other speaker say the words they are planning. Natural conversational timing requires the speaker to make use of knowledge about language, particularly grammar, to align with the other person. In contrast, a metrical pattern allows a speaker to predict speech timing without relying heavily on language-based knowledge. Given that many PWAs have impaired grammar, we hypothesize that most PWAs will benefit more from speaking in unison to sentences with metrical vs. conversational timing patterns. However, there is great variation in linguistic, motor speech, and timing skills across PWAs, so metrical and conversational timing patterns are likely to have different degrees of effectiveness for different individuals. Results from this study will demonstrate how individual characteristics and speech timing affect whether or not a person with aphasia benefits from speaking in unison. Results will also indicate whether a speaker's ability to predict speech timing is necessary for a benefit of unison speech. Prediction ability will be measured by how closely the speaker aligns their speech with a spoken model.","","Interventional","Inclusion Criteria: +"66",56,"Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia","Aphasia Apraxia of Speech","December 4, 2018","NCT05248295","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech are most helpful. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? A possible mechanism for this benefit is examined, by testing whether the degree of alignment of a person's speech with that of another speaker can account for unison benefit.","Aphasia is an acquired language disorder, most commonly due to stroke. It can affect an individual's ability to speak, understand spoken language, read, and write. Many treatments designed to improve spoken language in persons with aphasia (PWAs) use unison speech, having the person with aphasia speak along with the clinician or with a recording. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech help them the most. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? This knowledge is important because understanding who benefits from this commonly used and potentially powerful therapy component, under which conditions they benefit, and why they do, is critical for customizing therapy so it can be as effective and efficient as possible. Unison speech is conducted using one of two different timing patterns: (1) a natural conversational pattern, which is used in everyday conversations, or (2) a metrical pattern, which follows a beat-based timing framework, as in songs or some poems. In either case, precisely aligning one's speech with that of another person (i.e., entraining one's speech) requires prediction: each speaker must plan their own speech motor commands before having heard the other speaker say the words they are planning. Natural conversational timing requires the speaker to make use of knowledge about language, particularly grammar, to align with the other person. In contrast, a metrical pattern allows a speaker to predict speech timing without relying heavily on language-based knowledge. Given that many PWAs have impaired grammar, we hypothesize that most PWAs will benefit more from speaking in unison to sentences with metrical vs. conversational timing patterns. However, there is great variation in linguistic, motor speech, and timing skills across PWAs, so metrical and conversational timing patterns are likely to have different degrees of effectiveness for different individuals. Results from this study will demonstrate how individual characteristics and speech timing affect whether or not a person with aphasia benefits from speaking in unison. Results will also indicate whether a speaker's ability to predict speech timing is necessary for a benefit of unison speech. Prediction ability will be measured by how closely the speaker aligns their speech with a spoken model.","","Interventional","Inclusion Criteria: Native-speaker fluency in American English (prior to stroke for people with aphasia) Controls must report no history of speech, language, neurological disorders, or stroke @@ -1682,7 +1659,7 @@ Inadequate hearing ability to reliably complete task: fail hearing screen Inadequate cognitive ability to understand and remember task: fail cognition screening (different measures for controls and people with aphasia) Inadequate speech repetition ability to complete task, or to be considered a control: fail speech repetition screening (different thresholds for controls and people with aphasia) Inadequate auditory comprehension ability to understand task: fail auditory comprehension screen (people with aphasia only)","Accepts Healthy Volunteers","18 Years","All","Boston","02129","Massachusetts","Lauryn Zipse, Ph.D., CCC-SLP","United States",1,"no",-71.0537615,42.3756115,2018-12-04 -"68",59,"Individualized Precision rTMS for Language Recovery in Patients After Ischemic Stroke: a Multi-center RCT","Stroke, Ischemic Aphasia","June 5, 2023","NCT05842304","Changping Laboratory Beijing NA China","Changping Laboratory","Recruiting","The current multi-center study aims to evaluate the efficacy and safety of pBFS-guided rTMS Neuromodulation Treatment for the rehabilitation of language functions in ischemic stroke aphasic patients.","Increasing evidence suggests that rTMS has been effective in treating various psychological and neurological diseases, including treating post-stroke symptoms. Using the personalized brain functional sectors (pBFS) technique, we could precisely identify individualized brain functional networks and the personalized language-related stimulation site based on the resting-state functional MRI data. The current study proposes to conduct a multi-center, double-blinded, randomized and parallel controlled design trial, to investigate the efficacy and safety of pBFS-guided personalized TMS intervention in post-stroke aphasic patients. +"67",58,"Individualized Precision rTMS for Language Recovery in Patients After Ischemic Stroke: a Multi-center RCT","Stroke, Ischemic Aphasia","June 5, 2023","NCT05842304","Changping Laboratory Beijing NA China","Changping Laboratory","Recruiting","The current multi-center study aims to evaluate the efficacy and safety of pBFS-guided rTMS Neuromodulation Treatment for the rehabilitation of language functions in ischemic stroke aphasic patients.","Increasing evidence suggests that rTMS has been effective in treating various psychological and neurological diseases, including treating post-stroke symptoms. Using the personalized brain functional sectors (pBFS) technique, we could precisely identify individualized brain functional networks and the personalized language-related stimulation site based on the resting-state functional MRI data. The current study proposes to conduct a multi-center, double-blinded, randomized and parallel controlled design trial, to investigate the efficacy and safety of pBFS-guided personalized TMS intervention in post-stroke aphasic patients. Subjects will be randomly assigned to the following two groups: active continuous TBS (cTBS) group, or a sham control group. The allocation ratio will be 2:1. Subjects will receive a 3-week treatment for 21 consecutive days. The stimulation procedure will be assisted with real-time neuronavigation to ensure its precision.","","Interventional","Inclusion Criteria: @@ -1711,7 +1688,7 @@ History of alcohol, drug, and/or other abuse. Patients with other test abnormalities judged by the investigator to be unsuitable for the trial. Women of childbearing age who are pregnant or preparing for pregnancy. Patients who are participating in other clinical research trials.","No","35 Years","All","Beijing",NA,NA,NA,"China",1,"no",116.225091,40.219646,2023-06-05 -"69",63,"Treatment Outcomes With tDCS in Post-Stroke Aphasia","Aphasia","September 3, 2019","NCT03929432","University of Arkansas Little Rock Arkansas United States","University of Arkansas","Recruiting","The purpose this study is to test the utility of pairing external neuromodulation with behavioral language treatment to boost therapy outcomes and to investigate the mechanisms associated with recovery. Because all PWA have word retrieval deficits, this project will test if greater language gains can be achieved by supplementing anomia intervention with excitatory brain stimulation to the left hemisphere and will evaluate associated functional brain changes to aid the optimization of neural reorganization to facilitate language processing.","Aphasia is a language impairment that commonly occurs following brain damage (e.g., stroke). While language rehabilitation can yield improved language functioning, treatment outcomes vary greatly across individuals. In chronic aphasia, language gains occur through the brain's inherent ability to reorganize (i.e., neuroplasticity). +"68",62,"Treatment Outcomes With tDCS in Post-Stroke Aphasia","Aphasia","September 3, 2019","NCT03929432","University of Arkansas Little Rock Arkansas United States","University of Arkansas","Recruiting","The purpose this study is to test the utility of pairing external neuromodulation with behavioral language treatment to boost therapy outcomes and to investigate the mechanisms associated with recovery. Because all PWA have word retrieval deficits, this project will test if greater language gains can be achieved by supplementing anomia intervention with excitatory brain stimulation to the left hemisphere and will evaluate associated functional brain changes to aid the optimization of neural reorganization to facilitate language processing.","Aphasia is a language impairment that commonly occurs following brain damage (e.g., stroke). While language rehabilitation can yield improved language functioning, treatment outcomes vary greatly across individuals. In chronic aphasia, language gains occur through the brain's inherent ability to reorganize (i.e., neuroplasticity). While Speech-language therapy (SLT) can target various language skills and modalities, the most pervasive deficit across all persons with aphasia (PWA) is difficulty with word finding. Thus, aphasia treatment often includes some form of intervention focused on improving naming abilities. As with language function in general, naming abilities in PWA seems to be associated with left hemisphere recruitment, particularly with the viable tissue at the rim of the lesion (perilesional areas). This project investigates an innovative approach to improving current therapy by examining the benefits of using excitatory transcranial direct current stimulation (tDCS) stimulation/neuromodulation during anomia treatment (i.e. word-finding treatment). @@ -1738,7 +1715,7 @@ Co-occurring history of neurological disease/disorder/injury (e.g., traumatic br Co-occurring history of a major mental illness (e.g., schizophrenia, drug addiction, bipolar) Clinical conditions contraindicated for MRI or tDCS (e.g., implanted electrical devices, claustrophobia, seizure disorder) Positive pregnancy test (for females)","No","18 Years","All","Little Rock","72205","Arkansas",NA,"United States",1,"no",-92.3396525,34.7224165,2019-09-03 -"70",74,"Transcranial Alternating Current Stimulation (tACS) in Aphasia","Aphasia Stroke","January 4, 2020","NCT04375722","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States (NIH-NIDCD, 2015). Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits by providing brain stimulation concurrent with therapies. Transcranial direct current stimulation (tDCS) is one of the most widely used such technique. While tDCS has had relative success in chronic aphasia (>6 months after stroke), it has not been efficacious during subacute stages (<3 months after stroke). But enhancing language recovery early after stroke is desirable because of its potential impact on long-term language outcomes and quality-of-life. +"69",72,"Transcranial Alternating Current Stimulation (tACS) in Aphasia","Aphasia Stroke","January 4, 2020","NCT04375722","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States (NIH-NIDCD, 2015). Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits by providing brain stimulation concurrent with therapies. Transcranial direct current stimulation (tDCS) is one of the most widely used such technique. While tDCS has had relative success in chronic aphasia (>6 months after stroke), it has not been efficacious during subacute stages (<3 months after stroke). But enhancing language recovery early after stroke is desirable because of its potential impact on long-term language outcomes and quality-of-life. The current study will investigate the efficacy of high-definition tACS (HD-tACS) to help restore neural oscillatory activity in aphasia. TACS differs from tDCS in that sinusoidal, alternating currents are delivered rather than constant currents. TACS can manipulate the ongoing oscillatory neuronal activity and potentially increase functional synchronization (or connectivity) between targeted areas. This feature of tACS is quite attractive, given the new body of evidence suggesting that language impairments stem from diminished functional connectivity and disruptions in the language network due to stroke. The selection of tACS frequencies in this study is guided by our preliminary work examining pathological neural oscillations found near stroke-lesioned areas (or perilesional) in aphasia. By exogenously tuning the perilesional oscillations with tACS, the investigators hope to up-regulate communication across these areas and other connected areas to improve language outcome. If successful, tACS will be a powerful and novel treatment approach with reverberating positive impact on long-term recovery. @@ -1770,7 +1747,7 @@ Any metal implants in the skull Contraindications to MRI or tACS History of seizures History of dyslexia or other developmental learning disabilities","Accepts Healthy Volunteers","18 Years","All","Milwaukee","53226","Wisconsin","Priyanka Shah-Basak, PhD","United States",1,"no",-88.022002,43.04338,2020-01-04 -"71",79,"Treatment of Grammatical Time Marking in Post-Stroke Aphasia","Brain Injury, Vascular Aphasia Stroke","December 30, 2022","NCT05656638","University of Neuchatel Neuchâtel NA Switzerland","University of Neuchatel","Recruiting","The study aims to assess a individual or group therapy's effectiveness in grammatical time marking. The main objective is to examine whether the therapy improves grammatical time marking of inflected verbs treated on the sessions. We also explore whether the observed progress can be transferred to untrained items, more ecological contexts and if is maintained two and four weeks after the end of treatment. +"70",77,"Treatment of Grammatical Time Marking in Post-Stroke Aphasia","Brain Injury, Vascular Aphasia Stroke","December 30, 2022","NCT05656638","University of Neuchatel Neuchâtel NA Switzerland","University of Neuchatel","Recruiting","The study aims to assess a individual or group therapy's effectiveness in grammatical time marking. The main objective is to examine whether the therapy improves grammatical time marking of inflected verbs treated on the sessions. We also explore whether the observed progress can be transferred to untrained items, more ecological contexts and if is maintained two and four weeks after the end of treatment. This therapy will be administered to nine individuals with brain lesions after stroke. Five individuals will take part of the individual therapy and four individuals will take part of the group therapy (two individuals per group). The therapy will last one month, at the rate of three weekly sessions of approximately one hour.",NA,"","Interventional","Inclusion Criteria: @@ -1787,7 +1764,7 @@ Have significant impairments in oral/written comprehension. Present apraxia of speech or a severe arthritic disorder Present hemineglect Present impaired judgment and discernment, objectified by a neuropsychological evaluation","No","18 Years","All","Neuchâtel","2000",NA,"Marion Fossard","Switzerland",1,"no",6.931074,46.993392,2022-12-30 -"72",82,"Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia","Stroke Aphasia Apraxia of Speech","July 22, 2020","NCT04816799","Arizona State University Tempe Arizona United States","Arizona State University","Recruiting","A stratified, parallel-group, double-blind, randomized controlled trial of remotely delivered START treatment to individuals with severe-to-moderate stroke (with recruitment focused on individuals with low SES) will be conducted. Subjects and assessors will be blinded to the condition making the experiment double blind. Specifically, subjects will be told that we are exploring a new therapy that using different sounds to improve therapy. Parallel group design will ensure that subjects in the Control group are unaware that their ""sounds"" are softer than the START group. Trainers may become aware that a loud sound is present thus a unique Assessor will evaluate clinical performance before and after training making the study double-blind. Fifty-four subjects will undergo baseline testing in the laboratory to establish their capacity for functional and expressive speech as well as their self-reported health-related quality of life (power analysis below). Next, subjects will participate in a high-frequency, word-picture verification/ auditory-repetition treatment, 2 hr/day for 5 consecutive days focusing on expression of words of functional significance (e.g., water, fall). Subjects will either receive training with START or without (Control). Subjects will be re-tested immediately following training as well as one-month post to assess retention. Aim 1 will evaluate capacity of START to enhance SLT outcomes by assessing the % change in clinical assessment of functional and expressive speech. Our preliminary data points to a robust response [details]. Aim 2 will focus on the capacity of these changes to 1) be retained and 2) impact subject's reported quality of life. NOTE: While we are planning in-person baseline, end, and retention testing, in response to COVID, we have established remote clinical screening using peer-reviewed validated techniques for WAB and ABA-2 (see Alternative Solutions). All preliminary data collected for this proposal were collected remotely via no-contact protocols.",NA,"","Interventional","Inclusion Criteria: +"71",80,"Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia","Stroke Aphasia Apraxia of Speech","July 22, 2020","NCT04816799","Arizona State University Tempe Arizona United States","Arizona State University","Recruiting","A stratified, parallel-group, double-blind, randomized controlled trial of remotely delivered START treatment to individuals with severe-to-moderate stroke (with recruitment focused on individuals with low SES) will be conducted. Subjects and assessors will be blinded to the condition making the experiment double blind. Specifically, subjects will be told that we are exploring a new therapy that using different sounds to improve therapy. Parallel group design will ensure that subjects in the Control group are unaware that their ""sounds"" are softer than the START group. Trainers may become aware that a loud sound is present thus a unique Assessor will evaluate clinical performance before and after training making the study double-blind. Fifty-four subjects will undergo baseline testing in the laboratory to establish their capacity for functional and expressive speech as well as their self-reported health-related quality of life (power analysis below). Next, subjects will participate in a high-frequency, word-picture verification/ auditory-repetition treatment, 2 hr/day for 5 consecutive days focusing on expression of words of functional significance (e.g., water, fall). Subjects will either receive training with START or without (Control). Subjects will be re-tested immediately following training as well as one-month post to assess retention. Aim 1 will evaluate capacity of START to enhance SLT outcomes by assessing the % change in clinical assessment of functional and expressive speech. Our preliminary data points to a robust response [details]. Aim 2 will focus on the capacity of these changes to 1) be retained and 2) impact subject's reported quality of life. NOTE: While we are planning in-person baseline, end, and retention testing, in response to COVID, we have established remote clinical screening using peer-reviewed validated techniques for WAB and ABA-2 (see Alternative Solutions). All preliminary data collected for this proposal were collected remotely via no-contact protocols.",NA,"","Interventional","Inclusion Criteria: 18 years old Native English Speakers @@ -1801,7 +1778,7 @@ Corrected pure tone threshold (octave frequencies 250- 4000 Hz) norms for their Exclusion Criteria: Severe concurrent uncontrolled medical problems (e.g. cardiorespiratory impairment).","No","18 Years","All","Tempe","85287","Arizona","Claire Honeycutt","United States",1,"no",-111.932727,33.416893,2020-07-22 -"73",85,"tDCS Effects on Brain Plasticity in Aphasia Treatment","Aphasia Stroke","November 1, 2021","NCT05483556","The Hong Kong Polytechnic University Kowloon NA Hong Kong","The Hong Kong Polytechnic University","Recruiting","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI. +"72",83,"tDCS Effects on Brain Plasticity in Aphasia Treatment","Aphasia Stroke","November 1, 2021","NCT05483556","The Hong Kong Polytechnic University Kowloon NA Hong Kong","The Hong Kong Polytechnic University","Recruiting","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI. This randomized, placebo-controlled, double-blinded pilot study will recruit ten chronic stroke patients with Broca's Aphasia randomly assigned either to sham or an anodal tDCS groups. Following speech and language assessment, all the participants will receive 20 minutes of individualized language therapy daily for ten days in two consecutive weeks. Simultaneously, the treatment group will receive 20 minutes of 2mA anodal HD-tDCS over the left IFG, while the sham group will receive the 30s of 2mA anodal HD-tDCS. Structural, resting state and task activated functional MRI will be performed. Data acquisition will be performed before, immediately after and two months after the treatment. @@ -1822,7 +1799,7 @@ Wernicke's aphasia and other speech disorders, degenerative, psychiatric or meta Deaf, blind, pregnant/ or preparing for pregnancy, cognitive issues, tattoos Have cochlear implants, pacemaker, surgical nails for bone fracture, artificial joints, dental braces, dentures Taking anti-depressant medications","No","18 Years","All","Kowloon",NA,NA,"Dr Min Wong","Hong Kong",1,"no",114.179821,22.3046025,2021-11-01 -"74",87,"Effects of Verb Network Strengthening Treatment (VNeST) on Word Finding in Aphasia","Anomia Aphasia Stroke","January 16, 2022","NCT05152979","Göteborg University Gothenburg Västra Götaland Sweden","Göteborg University","Recruiting","Although there is evidence that speech-language therapy may improve speech in language disorders following left hemisphere stroke there is still a lack of evidence for which types of therapy are effective. Furthermore, in Sweden, as well as in several other countries, access to speech-language therapy is limited. The purpose of this clinical trial is to compare outcome from Verb Network Strengthening Treatment (VNeST) provided as In-Clinic therapy (I-CT) or as synchronous telepractice therapy (TP-T).","Every year thousands of persons in Sweden suffer from brain damage resulting in anomia, that is, word finding difficulties affecting their ability to talk to other people. Anomia is one of the most common and persistent symptoms of aphasia following a left hemisphere stroke, but it is also common in in progressive neurological diseases such as Parkinson's disease or multiple sclerosis (MS). There is evidence that more intensive speech language therapy may improve speech even in a chronic (> six month post stroke) phase of aphasia. However, access to the necessary amount of speech language therapy is limited due to lack of financial resources as well as to limitations to service providers in more rural areas. +"73",85,"Effects of Verb Network Strengthening Treatment (VNeST) on Word Finding in Aphasia","Anomia Aphasia Stroke","January 16, 2022","NCT05152979","Göteborg University Gothenburg Västra Götaland Sweden","Göteborg University","Recruiting","Although there is evidence that speech-language therapy may improve speech in language disorders following left hemisphere stroke there is still a lack of evidence for which types of therapy are effective. Furthermore, in Sweden, as well as in several other countries, access to speech-language therapy is limited. The purpose of this clinical trial is to compare outcome from Verb Network Strengthening Treatment (VNeST) provided as In-Clinic therapy (I-CT) or as synchronous telepractice therapy (TP-T).","Every year thousands of persons in Sweden suffer from brain damage resulting in anomia, that is, word finding difficulties affecting their ability to talk to other people. Anomia is one of the most common and persistent symptoms of aphasia following a left hemisphere stroke, but it is also common in in progressive neurological diseases such as Parkinson's disease or multiple sclerosis (MS). There is evidence that more intensive speech language therapy may improve speech even in a chronic (> six month post stroke) phase of aphasia. However, access to the necessary amount of speech language therapy is limited due to lack of financial resources as well as to limitations to service providers in more rural areas. It has been suggested that telepractice may increase the access to speech-language therapy for more people but there is a lack of knowledge of whether there is a difference in outcome from interventions provided as In-Clinic therapy (I-CT) or as telepractice therapy (TP-T). @@ -1844,7 +1821,7 @@ Moderately or severely impaired comprehension Moderate-severe apraxia of speech or dysarthria which may interfere with assessment Participation in any other speech-language treatment during the study Active substance dependence","No","18 Years","All","Gothenburg","40530","Västra Götaland",NA,"Sweden",1,"no",11.961307,57.6970935,2022-01-16 -"75",88,"Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia","Aphasia Non Fluent Stroke","May 5, 2022","NCT04433351","University Hospital, Grenoble Grenoble NA France","University Hospital, Grenoble","Recruiting","SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that aims first, to test and develop a novel speech rehabilitation program designed for patients with non-fluent aphasia and, second, to better describe neural reorganization after successful recovery. To this end, the investigators will conduct a prospective monocentric cross-over study, including two cohorts of post-stroke aphasic patients and two control groups.","In this project, the investigators propose to evaluate the effectiveness of a new rehabilitation program, based on illustration of speech articulators, to improve speech in patients with non-fluent aphasia. The instigators' method is based on the reinforcement of the interaction between perceptual and motor representations, thanks to the innovative Ultraspeech device. The investigators will exploit a fundamental psycholinguistic principle, which postulates that speech is based both on the activation of the system controlling the motricity of effectors related to word articulation (action) and on the auditory or visual representation of words (perception). The sensory-motor interaction method that the investigators propose allows the patient to perceive phonemes and visualize on a computer screen the movements of the tongue and lips previously recorded by a healthy speaker, typically a speech therapist. Through repeated exercises, the patient is trained to produce sounds correctly, using the correct pronunciation and articulatory movements of the reference speaker as a model. The investigators will compare patients who will follow a classical speech and language therapy rehabilitation program followed by an 'enriched' rehabilitation program including rehabilitation based on sensory-motor interaction associated with speech and language therapy, and vice versa. In order to judge the favorable effect of the rehabilitation program including sensory-motor integration, the following measures will be considered: (a) language skills, (b) phonemic quality, (c) inner speech abilities and (d) cognitive function. Brain language networks will be evaluated with neuroimaging.","post-stroke aphasia non-fluent aphasia speech rehabilitation neuroimaging neural reorganization recovery","Interventional","Inclusion Criteria: +"74",86,"Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia","Aphasia Non Fluent Stroke","May 5, 2022","NCT04433351","University Hospital, Grenoble Grenoble NA France","University Hospital, Grenoble","Recruiting","SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that aims first, to test and develop a novel speech rehabilitation program designed for patients with non-fluent aphasia and, second, to better describe neural reorganization after successful recovery. To this end, the investigators will conduct a prospective monocentric cross-over study, including two cohorts of post-stroke aphasic patients and two control groups.","In this project, the investigators propose to evaluate the effectiveness of a new rehabilitation program, based on illustration of speech articulators, to improve speech in patients with non-fluent aphasia. The instigators' method is based on the reinforcement of the interaction between perceptual and motor representations, thanks to the innovative Ultraspeech device. The investigators will exploit a fundamental psycholinguistic principle, which postulates that speech is based both on the activation of the system controlling the motricity of effectors related to word articulation (action) and on the auditory or visual representation of words (perception). The sensory-motor interaction method that the investigators propose allows the patient to perceive phonemes and visualize on a computer screen the movements of the tongue and lips previously recorded by a healthy speaker, typically a speech therapist. Through repeated exercises, the patient is trained to produce sounds correctly, using the correct pronunciation and articulatory movements of the reference speaker as a model. The investigators will compare patients who will follow a classical speech and language therapy rehabilitation program followed by an 'enriched' rehabilitation program including rehabilitation based on sensory-motor interaction associated with speech and language therapy, and vice versa. In order to judge the favorable effect of the rehabilitation program including sensory-motor integration, the following measures will be considered: (a) language skills, (b) phonemic quality, (c) inner speech abilities and (d) cognitive function. Brain language networks will be evaluated with neuroimaging.","post-stroke aphasia non-fluent aphasia speech rehabilitation neuroimaging neural reorganization recovery","Interventional","Inclusion Criteria: patients with late sub-acute and chronic post-stroke (> 4 months) non-fluent aphasia after lesion in the dominant hemisphere for language native speakers of French @@ -1854,7 +1831,7 @@ satisfying all criteria for the MRI examination Exclusion Criteria: patients with comprehension deficits, hemi-spatial neglect or upper limb apraxia","No","55 Years","All","Grenoble","38043",NA,NA,"France",1,"no",5.735782,45.18756,2022-05-05 -"76",89,"Effects of Transcranial Direct Current Stimulation (tDCS) on Language","Stroke Aphasia","December 1, 2019","NCT04166513","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). +"75",87,"Effects of Transcranial Direct Current Stimulation (tDCS) on Language","Stroke Aphasia","December 1, 2019","NCT04166513","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). This study will examine the effects of tDCS during speech therapy to further examine which method or methods is best for patient recovery. Patients enrolled in the study will undergo language testing that covers a broad range of language functions. Functional Magnetic Resonance Imaging (fMRI) will be completed before and after speech therapy intervention arms to investigate the neural processes affected by tDCS and speech therapy. @@ -1872,7 +1849,7 @@ Advanced neurodegenerative disease (i.e. Stage 3 Alzheimer's disease) or neurolo Severe psychopathology (e.g. schizophrenia, bipolar disorder, acute major depressive episode) No suspected or diagnosed uncorrectable hearing or vision difficulties, or developmental disabilities (i.e. intellectual disability or learning disability). Contraindications to MRI such as claustrophobia, implanted electronic devices, MRI-incompatible metal in the body, extreme obesity, pregnancy, inability to lie flat, and inability to see or hear stimulus materials","No","18 Years","All","Milwaukee","53226","Wisconsin","Sara Pillay","United States",1,"no",-88.022002,43.04338,2019-12-01 -"77",90,"Intention Treatment for Anomia","Aphasia Stroke","May 24, 2021","NCT04267198","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia). Stroke-induced aphasia results in increased healthcare costs and decreased quality of life. As the population of Veterans continues to age, there will be an increasing number for Veterans living with the aphasia and its consequences. Those Veterans deserve to receive aphasia treatment designed to facilitate the best possible outcomes. In the proposed study, the investigators will investigate optimal treatment intensity and predictors of treatment response for a novel word retrieval treatment. The knowledge the investigators gain will have direct implications for the selecting the right treatment approach for the right Veteran.","Difficulty retrieving words is one of the most common language complaints in individuals with stroke-induced aphasia. The negative consequences related to word retrieval impairment include increased health care costs and decreased quality of life. A variety of treatment approaches exist to improve word retrieval, and most of the treatments result in immediate improvement on trained words. However, long-term improvement and improvement on untrained words or behaviors is less common. Additionally, the investigators currently know very little about optimal treatment administration parameters, and the investigators know even less about predictors of treatment response. To make the best use of the limited clinical resources available for aphasia treatment, and to maximize outcomes for Veterans with aphasia, the investigators must: 1) develop clinically translatable treatments that yield widespread and lasting effects and 2) develop clinically accessible ways of identifying who will acquire benefit from a specific treatment approach. This study takes on these two challenges by investigating dose frequency (massed vs. distributed practice) effects and by identifying the language, cognitive and neural predictors of response to Intention treatment (INT), a novel word retrieval treatment. Specifically, the investigators will address the following aims: +"76",88,"Intention Treatment for Anomia","Aphasia Stroke","May 24, 2021","NCT04267198","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia). Stroke-induced aphasia results in increased healthcare costs and decreased quality of life. As the population of Veterans continues to age, there will be an increasing number for Veterans living with the aphasia and its consequences. Those Veterans deserve to receive aphasia treatment designed to facilitate the best possible outcomes. In the proposed study, the investigators will investigate optimal treatment intensity and predictors of treatment response for a novel word retrieval treatment. The knowledge the investigators gain will have direct implications for the selecting the right treatment approach for the right Veteran.","Difficulty retrieving words is one of the most common language complaints in individuals with stroke-induced aphasia. The negative consequences related to word retrieval impairment include increased health care costs and decreased quality of life. A variety of treatment approaches exist to improve word retrieval, and most of the treatments result in immediate improvement on trained words. However, long-term improvement and improvement on untrained words or behaviors is less common. Additionally, the investigators currently know very little about optimal treatment administration parameters, and the investigators know even less about predictors of treatment response. To make the best use of the limited clinical resources available for aphasia treatment, and to maximize outcomes for Veterans with aphasia, the investigators must: 1) develop clinically translatable treatments that yield widespread and lasting effects and 2) develop clinically accessible ways of identifying who will acquire benefit from a specific treatment approach. This study takes on these two challenges by investigating dose frequency (massed vs. distributed practice) effects and by identifying the language, cognitive and neural predictors of response to Intention treatment (INT), a novel word retrieval treatment. Specifically, the investigators will address the following aims: Aim 1: To investigate dose frequency effects on maintenance and generalization of INT gains. Outcome measure: Word retrieval accuracy for trained and untrained words. @@ -1891,7 +1868,7 @@ Exclusion Criteria: Severe apraxia of speech or dysarthria Clinically significant depression For MRI safety: implanted medical devices, metal in the body and claustrophobia.","No","21 Years","All","Decatur","30033-4004","Georgia",NA,"United States",1,"no",-84.296069,33.773758,2021-05-24 -"78",92,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. +"77",91,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. All enrolled participants will be assessed on their mood, past music experience and music genre preference (music therapy assessment). They will complete the abridged Beck (BDI-2-fastscreen) questionnaire, the stoke and aphasia quality of life scale; a Likert which measures distress; the Western Aphasia Battery (WAB); the NIH Stroke Scale (SS); the Figely compassion scale; and the driving scene test (Stern and White); and the Rankin. In additional we will take saliva samples from all participants to measure hormone levels. @@ -1902,19 +1879,7 @@ Stroke victim, regardless of level of stroke Exclusion Criteria: None","No","18 Years","All","New York","10003","New York","Joanne Loewy","United States",1,"no",-73.953275,40.7898205,2014-04-04 -"79",99,"Home Program Practice for People With Language Disorders After Stroke","Aphasia Stroke","January 22, 2021","NCT04543084","Duquesne University Pittsburgh Pennsylvania United States","Duquesne University","Recruiting","Logbooks are one of the most commonly used methods to both support and track adherence in research studies. This study will look at using logbooks to support adherence to reading practice for individuals with post-stroke aphasia. It is thought that using a logbook will increase practice time.",NA,"","Interventional","Inclusion Criteria: - -at least 6 months post left hemisphere stroke with a diagnosis of aphasia -must have self-reported interest in working to improve reading comprehension -access to the Internet -speak English as a primary language - -Exclusion Criteria: - -significant visual or hearing impairment as determined by ""aphasia-friendly"" and age-appropriate screening -actively receiving speech-language pathology services in which computerized or reading comprehension home practice activities are assigned/requested -severe auditory comprehension impairment that limits understanding of one-step directions (i.e., Western Aphasia Battery-Revised sequential commands subtest score below 8).","No","18 Years","All","Pittsburgh","15228","Pennsylvania",NA,"United States",1,"no",-79.991974,40.4375005,2021-01-22 -"80",100,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: +"78",98,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: Stroke Survivors: @@ -1939,7 +1904,7 @@ Additional Exclusion Criteria for MRIs: Pacemaker or magnetic metal in the body that is not MRI compatible Pregnancy Claustrophobia","Accepts Healthy Volunteers","18 Years","All","Washington","20057","District of Columbia",NA,"United States",1,"no",-77.078807,38.911961,2018-11-01 -"81",102,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: +"79",100,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: Diagnosis of aphasia secondary to stroke and presence of naming deficits (at least 20% errors on the Boston Naming Test or Hopkins Action Naming Assessment) Capable of giving informed consent or indicating another to provide informed consent @@ -1953,7 +1918,7 @@ Lack of English proficiency (by self/legally authorized representative report) Prior history of neurologic disease affecting the brain (e.g., brain tumor, multiple sclerosis, traumatic brain injury) other than stroke Prior history of severe psychiatric illness, developmental disorders or intellectual disability (e.g., PTSD, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders) Uncorrected severe visual loss or hearing loss by self-report and medical records","No","18 Years","All","Baltimore","21287","Maryland",NA,"United States",1,"no",-76.6204945,39.3289375,2023-05-31 -"82",104,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. +"80",102,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. However, language processes are not determined solely by local neural activity at a single site, but rather by the interaction between neural networks. This is because a large cortical network is involved in language processes and, therefore, the same language disorder may result from lesions at different locations in this network. @@ -1979,7 +1944,7 @@ Impaired alertness or delirium Severe co-morbidity affecting speech Contraindication to tDCS: pregnant women, patients with active implants such as pacemakers or cochlear implants, patients with one or more seizures, metal objects in the brain Occurrence of a new stroke during the study protocol.","No","18 Years","All","Geneva","1211","GE","Adrian Guggisberg","Switzerland",1,"no",6.1486155,46.1937405,2022-10-24 -"83",110,"Prism Adaptation in Left Brain Stroke","Aphasia Spatial Neglect Stroke","February 15, 2021","NCT04387162","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Of the 15,000 Veterans who are hospitalized for stroke each year more than half experience spatial and motor impairments and pain. Spatial-motor-sensory problems limit functioning and independence, which is costly to Veterans, their families, and society. Currently, spatial-motor-sensory problems are targeted using different treatments. However, there is a treatment that has shown promise in simultaneously targeting spatial function, motor function and pain in right-brain stroke. The investigators propose to investigate the feasibility of using adapted spatial-motor sensory assessment and treatment procedures for Veterans with left-brain stroke who have language and cognitive impairment. The next step will be to conduct a large-scale study focused on this multi-target treatment for more efficient and effective stroke rehabilitation. The investigators expect this line of research to increase functioning, independence and quality of life in Veteran stroke survivors.","The functional disability experienced by Veterans after stroke, and the limited rehabilitation resources available, highlight the importance of identifying feasible treatments acting on more than one recovery target. Currently, there are separate and modality-specific treatment pathways for cognitive and motor impairments. These modality-specific treatment pathways lead to fragmentation of care, and under-identification and under-treatment of invisible disabilities, such as spatial neglect, aphasia and pain. The result is longer hospital stays, greater risk of falls, and poor functional outcomes. Employing a treatment that simultaneously addresses multiple targets will ensure that the investigators provide the needed care for >50% of post-stroke Veterans who have both visible and invisible disabilities, during the critical post-acute period of recovery. +"81",108,"Prism Adaptation in Left Brain Stroke","Aphasia Spatial Neglect Stroke","February 15, 2021","NCT04387162","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Of the 15,000 Veterans who are hospitalized for stroke each year more than half experience spatial and motor impairments and pain. Spatial-motor-sensory problems limit functioning and independence, which is costly to Veterans, their families, and society. Currently, spatial-motor-sensory problems are targeted using different treatments. However, there is a treatment that has shown promise in simultaneously targeting spatial function, motor function and pain in right-brain stroke. The investigators propose to investigate the feasibility of using adapted spatial-motor sensory assessment and treatment procedures for Veterans with left-brain stroke who have language and cognitive impairment. The next step will be to conduct a large-scale study focused on this multi-target treatment for more efficient and effective stroke rehabilitation. The investigators expect this line of research to increase functioning, independence and quality of life in Veteran stroke survivors.","The functional disability experienced by Veterans after stroke, and the limited rehabilitation resources available, highlight the importance of identifying feasible treatments acting on more than one recovery target. Currently, there are separate and modality-specific treatment pathways for cognitive and motor impairments. These modality-specific treatment pathways lead to fragmentation of care, and under-identification and under-treatment of invisible disabilities, such as spatial neglect, aphasia and pain. The result is longer hospital stays, greater risk of falls, and poor functional outcomes. Employing a treatment that simultaneously addresses multiple targets will ensure that the investigators provide the needed care for >50% of post-stroke Veterans who have both visible and invisible disabilities, during the critical post-acute period of recovery. Prism adaptation treatment (PAT) is a 10-day regimen reported to be inexpensive, replicable and effective for treatment of spatial neglect, and studies have demonstrated that it also enhances everyday activities and motor recovery and reduces chronic post-stroke pain in patients with right brain stroke. Additionally, brain mapping methods have shown that in patients with right brain stroke, those with frontal lesions respond optimally to PAT. No studies have investigated PAT in left-brain stroke patients with language and cognitive impairment. To address this research gap, the investigators will address the following aims: @@ -1998,7 +1963,7 @@ able to provide informed consent to participate, using aphasia-accessible proces Exclusion Criteria: History of brain conditions other than left brain stroke, including clinical right brain pathology.","No","18 Years","All","Decatur","30033-4004","Georgia",NA,"United States",1,"no",-84.296069,33.773758,2021-02-15 -"84",115,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: +"82",113,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: Posterior cortical atrophy - a version of Alzheimer's disease with vision difficulties Logopenic variant primary progressive aphasia - a version of Alzheimer's disease with language difficulties @@ -2032,7 +1997,7 @@ Conditions precluding entry into the scanners (e.g. morbid obesity, claustrophob Exposure to research related radiation in the past year that, when combined with this study, would place subjects above the allowable limits. Participation in the last year in a clinical trial for a disease modifying drug for AD. Taking immunosuppressive medication (e.g., glucocorticoids, cytostatics, antibodies, drugs acting on immunophilins, interferons, tumor necrosis factor inhibitors). Nonsteroidal anti-inflammatory drugs (NSAIDs) are not exclusionary.","Accepts Healthy Volunteers","50 Years","All","New York","10032","New York","James M Noble, MD, MS, CPH, FAAN","United States",1,"no",-73.9622875,40.807223,2020-11-17 -"85",167,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: +"83",165,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: to evaluate the residual neuroplastic processes in DOC state related to music exposure to determine the putative modulation of the aforementioned processes and the clinical outcome of DOC patients by non-pharmacological strategies, i.e., electric (tDCS) and music stimulation @@ -2053,9 +2018,9 @@ No hystory of psychiatric disease Previous stroke use of alcohol and drugs premorbid dementia","No","18 Years","All","Bari","70025","Ba","Simona Spaccavento","Italy",1,"no",16.862029,41.125784,2022-09-01 -"86",NA,"Functional reorganization of the language and domain-general multiple demand systems in aphasia",NA,"March 1, 2022","manual1","Boston, MA","Boston University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Boston",NA,"Massachusetts","Swathi Kiran",NA,NA,"no",-71.058291,42.360253,2022-03-01 -"87",NA,"Characterizing inner speech in aphasia",NA,"March 9, 2022","manual2","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 -"88",NA,"Inner speech as a naming therapy predictor in aphasia",NA,"March 9, 2022","manual3","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 -"89",NA,"Measuring and understanding the experience of post-traumatic growth in aphasia",NA,"March 9, 2022","manual4","Reno, NV","University of Nevada Reno",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Reno",NA,"Nevada","Tami Brancamp",NA,NA,"Online",-119.812658,39.526121,2022-03-09 -"90",NA,"Reading in Aphasia",NA,"January 1, 2020","manual5","Atlanta, GA","Georgia State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Atlanta",NA,"GA","Rachael Harrington",NA,NA,"Online",-84.390264,33.748992,2020-01-01 -"91",NA,"Assessment of anomia: Improving efficiency and utility using item response theory",NA,"August 31, 2020","manual6","Portland, OR","Portland State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Portland",NA,"OR","Gerasimos Fergadiotis",NA,NA,"no",-122.674195,45.520247,2020-08-31 +"84",NA,"Functional reorganization of the language and domain-general multiple demand systems in aphasia",NA,"March 1, 2022","manual1","Boston, MA","Boston University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Boston",NA,"Massachusetts","Swathi Kiran",NA,NA,"no",-71.058291,42.360253,2022-03-01 +"85",NA,"Characterizing inner speech in aphasia",NA,"March 9, 2022","manual2","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 +"86",NA,"Inner speech as a naming therapy predictor in aphasia",NA,"March 9, 2022","manual3","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 +"87",NA,"Measuring and understanding the experience of post-traumatic growth in aphasia",NA,"March 9, 2022","manual4","Reno, NV","University of Nevada Reno",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Reno",NA,"Nevada","Tami Brancamp",NA,NA,"Online",-119.812658,39.526121,2022-03-09 +"88",NA,"Reading in Aphasia",NA,"January 1, 2020","manual5","Atlanta, GA","Georgia State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Atlanta",NA,"GA","Rachael Harrington",NA,NA,"Online",-84.390264,33.748992,2020-01-01 +"89",NA,"Assessment of anomia: Improving efficiency and utility using item response theory",NA,"August 31, 2020","manual6","Portland, OR","Portland State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Portland",NA,"OR","Gerasimos Fergadiotis",NA,NA,"no",-122.674195,45.520247,2020-08-31 diff --git a/data/contact.rds b/data/contact.rds index 251af2f2a8843edfba8d7b98a350047563c7e5cf..4203112611e6ccb9e43c4f790ad15845b2e4c5d5 100644 GIT binary patch delta 113 zcmX>T+8;bYmN9vwoHYC794^z%3)m}|Hk)wWV`NO;EX;F(WwN56*k(n+i;SDug#AE* zp&}7%o8L*LF>NlDodXn@tST?R*-$=_W%6ld;mxO&7c)+tqAIj_vMNaN9JLorlc#Iy PPd==OigYDy^s3j-$u1A{=jI+A}RTK`NjE3Mfv4v7AuKaBM@PXoz(c_~z+4JiQ!_&o0|Tg;+22i2N tYn9|T?^IgM$YyF{Y+zxs*)?MC$Cpz+q_wUkr~KfpUkZ)GTB;HVDf$CiplXRPe78B164l*m1e8SPcByz-dwK6 z%{+OxrZ5O^-mRI)G+AHg7|`TzI{IvzU5uZyY<97j&j=Jyuu^B9EN^>*arxvQw!44= So9*;iCjWGr1{9d!>yv)3Gg%TI%V1>lI6a{BbpAd!2JO#h}Jl(XM z($u_?$$Y#)lVy3GH_P%$@>sfhBQuc%;Z#swEQB4fYkhgoK%JI z%#sWRpTxZM(!}&s1((d?{Gyc9qTjqt7;Zh9N(vZ)RRzYH@x^ z;^YW(^~v$(3Lw0BuTd)thpe~F g=FGL#V-aKEWnf@n1mY+lhOvQ8a-0EFm*nIO0GugqH2?qr diff --git a/data/location.rds b/data/location.rds index ae605e799e233dcb12d6ce2427b48d47ffebf054..ec1801bff6ac94a3f8e863a0dd76397028035066 100644 GIT binary patch delta 88 zcmZqCe62n~meFpb++4=Z=NK0;Zf<7wVq~sm1vviJMn)od&5je_vu%0I(deC|E>C)_XG^~wCld%=-n z;fz{TS8f=_c~-$3R?9B3dUlyLuq&*QHL+`~m9?>U*2%irwDbvEII2XH=BbB)S02?L z`hvod=ggDpR$(2=v}wx5B2z}geq|r)5OShuhYt)Mp9U2xwuHQCedKY}_Ip*sDI3&q z$y31-)u(@=tck?9?2pX%sNXN&S<3zNBAn|O9wXN<0CAo;1MeL z17WhqF-KQE!MrdZNhGmc_a$*g(0URhbmlD%98~$Uc$;rXa0g==e~hK@5|6u6*bKCj z!T@c|AwNO;-s5wi>+|R%oyPrxDwDxqyf(Lhi-LxhFiIm!==Fv;SBL6nv5XR%;G;Jg z^dH71NTVO{9_OEpB1pR{cqbbLe}y1j_>A|nQT&fWu3}3zihoh))isQPSSGQ7@xPd& BuJ!-` delta 5457 zcmaJ_ZH!!18ScHeE$v`SYd^MpY!8i8nzCDgsS43T()bNCLzliD-}#J$AeD3Kb_7UbL|9(pOhb9==7nf*lJ~HQ+A(ayyc?U=1Wf6pIq7sRK9ghMvBNqO8*#{Q3e`Axhh6X468V@D!+KaV+N*`wj z0}fxNysyN86k+qRZM_QzdLA{J{XJWoZ*BV{EIohubLJ&`_Us)R9UNRZaMkt3>OG?) zgJYx3`+DEU?ZNG9R&DFK%agNkMMia|D(p7tc_LI1Ul_V(m$`YC01iAqHT z$N{tQrz9MQ2L)RN2t9Y0&!gHLud_Hr29p#2Fb3{s2q@#sS2!!S!^S#?NEB?AWoWB7 z2;l{yQG$i^W?d(qjzdUrg{uN`8UM<1R+eM#BsUp~5drrAr)1-9 zV{?O^De(Z@1kZ6~pHn&|fJqqcc81Q+%S1xNVHPGsMx>+XJdTXRJdfC%gb%yXiI~Frjz3! z$-W3|xI>bKI82V@+2m(+kS6^h$`g*10(x>3x5o0>z2OXV0qui5!U(`;09*%!c#u1Q zD)@*f*{ViFw!ysyqPmQ1%QB}O1~oKm>5Eq=aeIbE*i2g+=|}Xqlj)fwD+un=&bcrI9^d&^-NohG7E$EwbJgliWqTH86grB@3 zJG8i6hNk_57jnN_yV8=`NNExXsLOIPcR3reVRxeK^Y9=;v51k*B0J3OTBi00ttJ43 zba7=Fl@IvJ%5qo0vU6;7P=-C|SDv;9Q)RND-`LU6`k{lY*B04PqOJCsn9*iA)eGU3 zX}R7)J3u*te_F+sI78JQO3%w_I&kFSJ&Q+~2r2lkCif&j){&Xz^(KD-{t?8BawmEG z7GvxF3aS=^)52H4OqfTi;0Z8~Wn6a`f}*$tPg?1V3m=?*eS5>W_K2#Ml$rrXHK|An zQh`xm6j<&m4;3e-GLUMHma~!qRKnQzQKj@|2r6jE%NdsmH4p&71ME%!Mvp>F0vFnF zhMqYGu``3Z={n6IW~nRC%Z}}iMf?aTl_}+ZSC7?fh-)W`Yzjc7szv26!rzWjC}V22 zEul8708bqo6usiYW3QdvVvIk$?_6u&Ipd?+{#AdzD0i1L70@Cs7c`ksH)YjJ)}Ju9 zCBJ*$T+`6Ml2DL_BCbPYtd5ZAG_f0*14kmZ7tM_q)lecS;;|4R={$d*zq8m}oH-Edm zffh+newO(mZu$>+}d(ygJZ`;9XcGbjjd2c!Ws6)+d#iWu+uJ8kk!e#awO@sYuT; zeQ3IHXImk@KqClBoxXKE6JZtP*)0lm|2+Qd$9#ZFwP$`03sK%ZQ3w^E!C^xmcad&~ zI$Y2INT5~;aMPOA!4~%#xXaLYQ`6XCW}3UM@>CP941JQZ8`zNTf{>t=PTwfLwKJQE zB${XPnp&?;KSeYKnQ+kd!;WH%i{wIE<+C7ZGbs`^H>xq(WXhKw1;~S9YyA!8&Qh}WIcr^O^t8EgyD{FH{F(XT zC6}yRu@-aqHE_@=dG zcLx{C6g!8?718jA#HVtcYkunZPCyz!<0Z`a;4|b%_|!6ZG^A1iiv<-9*0lNuQP`i)rSC72pYE`(*?BAwRS%;}9lLg&Qpg7}W5QLQ zIKFjxqogqX_365yi!dD%AgX|E*qw}at#&1VLRrt}e7x;;12Nt?qHo0)smgJSyyZv zK$}IizPLgIYxO-k$H}Gdn^(7@Tdg1NPu`oidJLXS{L0*tyuR7$OUu>j%%r@D=iTys{JT&#jq^b*9WC%wbgmC1&;%(Ya-Q+Vjp(QHqM^wEn4m=GbE zx`^u3FF7Eq5sW+Sl(vkK1cav^fFoH|RQZ8G=&4qebJQ&aB02wox$PiAhZ$FEneN#f z=}L4Di`*fMAipS91<0!3#UVhyD2n;S7_!(XoQHYz<_He)2sA*a8JF~2h<7{i1n-E{ z92@J;&|t08XlM;QVr@j{*P3|JI&UOzJY|h1zoh>j_^$Oi`t%e;pX$`()J#D0`KmB9t>&6AY-un}4 g?!sT6e9`*G@?XXBA6B<6eZ|^q8gC>ATh@{P0VaB!RR910 diff --git a/docs/about.html b/docs/about.html index eeb8b05..612d9ce 100644 --- a/docs/about.html +++ b/docs/about.html @@ -2344,7 +2344,7 @@

About this Website

This website was built primarily using data from the clinicaltrials.gov API to identify studies that included a keyword or condition listing of Aphasia (excluding primary progressive aphasia and other dementias.)

-

It was last updated on August 28 2023

+

It was last updated on September 04 2023

To add your study to this website, submit the study to clinicaltrials.gov. This has a number of benefits for the research community and general public. While submission to clinicaltrials.gov is required for funded clinical trials in the US, voluntary submission is also permitted for other studies.

If submitting your study to clinicaltrials.gov is not feasible or is overly burdensome, you can add an IRB-approved flyer to the website by submitting an issue on github.com. Note that you will will need to create a github account. This is free and helps me keep track of submissions.

If you notice an error on the website, please contact me or file an issue here.

diff --git a/docs/data/clinical_trials_clean.csv b/docs/data/clinical_trials_clean.csv index a609811..2ba0dd4 100644 --- a/docs/data/clinical_trials_clean.csv +++ b/docs/data/clinical_trials_clean.csv @@ -1093,30 +1093,7 @@ Recurrence of a stroke impacting the reorganisation of neural networks Persons deprived of their liberty by a judicial or administrative decision Persons of legal age under a legal protection measure (guardianship, curatorship) Pregnant women, women in labour or nursing mothers, confirmed by questioning the participant Participation in another study at the same time as this one","Accepts Healthy Volunteers","18 Years","All","Saint-Genis-Laval","69230",NA,NA,"France",1,"no",4.792883,45.695002,2023-05-26 -"44",48,"Combining tDCS and CILT in Non-fluent Aphasia","Aphasia Non-fluent Aphasia Stroke Brain Injuries","April 24, 2023","NCT05561400","University of Minnesota Duluth Minnesota United States","University of Minnesota","Recruiting","The long-term goal of this work is to determine if combining a highly intensive, task-specific behavioral language intervention with modulation of the efferent cerebellar-cortical pathway using transcranial direct current stimulation (tDCS) has a positive influence on discourse, verbal fluency and working memory in individuals with non-fluent aphasia after stroke. And if these changes can be related to neuroplastic change in the cerebellar cortical pathway indirectly measured through neurophysiologic changes using spectral electroencephalogram (EEG). The initial phase includes the proposed pilot study data from which will be used to inform a larger clinical trial. The primary aims of this pilot are to 1) determine the effect of combining cerebellar tDCS with constraint-induced language therapy (CILT) on language as measured by a verbal fluency task and discourse task in a small population and 2) identify the tolerance of the intervention and barriers to participation measured by the adverse events questionnaire that will inform the methodology of a larger study. The secondary aims include estimating the size of the treatment effect on 1) delta percentage in F3, F7 and Fp1 compared to F4, F8, and Fp2 using resting state EEG spectral analysis and coherence, 2) working memory as measured by the score on the n-back test and 3) quality of life as measured by the Stroke Aphasia Quality of Life survey tool. The secondary aims will be used to determine the utility of these measures in a larger clinical trial. - -This is a prospective, crossover study, sham-controlled intervention study with two intervention conditions delivered across 6 intervention sessions (3x/week for two weeks) with a 4-week washout in between. Conditions include: 1) sham cerebellar tDCS and 2) real cerebellar tDCS delivered at 2mA across 20 minutes. Each of these will be delivered during CILT intervention with a licensed, certified speech-language pathologist trained in CILT. Once tDCS stimulation has ended, CILT will continue to be delivered for an additional 25 minutes. Assessments of discourse, verbal fluency, working memory and EEG spectral analysis will be conducted at four timepoints, before and after each intervention phase.","This is a prospective sham-controlled, cross-over design. Eligible participants must be over the age of 18 years, be > least 6 months post unilateral cortical stroke and diagnosed with mild to moderate non-fluent aphasia. Additional inclusion/exclusionary criteria have been specified in and approved by the IRB. Six to seven participants are expected to be recruited and screened, with the goal to enroll and complete the study with four individuals who will be randomly assigned to receive either sham or real condition first. The two intervention conditions include: 1) andodal tDCS (2mA) to the right posterior-lateral cerebellum and 2) sham tDCS to the right posterior-lateral cerebellum. The participants will receive 20 minutes of tDCS (sham or real) during CILT followed by an additional 25 minutes of CILT alone. Each condition will be administered 3 days per week for two weeks for a total of 6 intervention sessions with a 4-week washout period between. - -For tDCS (TCT-Research Version tDCS Stimulator, Hong Kong), two 5x5 saline-soaked sponge electrodes will be used with the anode placed over the right cerebellar hemisphere; 1cm under and 4cm lateral of the inion targeting the posterior lateral cerebellum and the cathode will be placed on the right shoulder. The electrode placement will be the same across both conditions. The CILT behavioral intervention will be led by a certified, licensed speech-language pathologist and a graduate student researcher and will follow the guidelines of CILT.","transcranial direct current stimulation (tDCS) non-invasive brain stimulation (NIBS) aphasia constraint-induced language therapy (CILT)","Interventional","Inclusion Criteria: - -over the age of 18 years -history of stroke -diagnosed with non-fluent aphasia. -be able to independently understand simple directions, -use some speech to communicate, -have access to reliable transportation (including taxi and/or other transportation services), -fluent in English. - -Exclusion Criteria: - -Pregnancy, -history of seizures, -any metal implants in the body (excluding dental fillings), -history of migraines, -psoriasis or eczema affecting the scalp, -history of a head injury such as a concussion -diagnosis of a mental health or neurological condition/disease.","No","18 Years","All","Duluth","55812","Minnesota",NA,"United States",1,"no",-92.08343,46.8190805,2023-04-24 -"45",49,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"44",48,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1139,7 +1116,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Baltimore","21287","Maryland",NA,"United States",1,"no",-76.6204945,39.3289375,2021-07-18 -"46",49,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Charleston South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"45",48,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Charleston South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1162,7 +1139,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Charleston","29425","South Carolina",NA,"United States",1,"no",-80.10815,32.792398,2021-07-18 -"47",49,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Columbia South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"46",48,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Columbia South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1185,7 +1162,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Columbia","29208","South Carolina",NA,"United States",1,"no",-81.034331,34.000749,2021-07-18 -"48",50,"HD-tDCS for Phonological Impairment in Aphasia","Aphasia Stroke","August 25, 2023","NCT06010030","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). +"47",49,"HD-tDCS for Phonological Impairment in Aphasia","Aphasia Stroke","August 25, 2023","NCT06010030","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). This study will examine the effects of tDCS during speech therapy to further examine which method or methods is best for patient recovery. Patients enrolled in the study will undergo language testing that covers a broad range of language functions. Functional Magnetic Resonance Imaging (fMRI) will be completed before and after speech therapy intervention arms to investigate the neural processes affected by tDCS and speech therapy. @@ -1220,7 +1197,7 @@ Contraindications to MRI such as claustrophobia, implanted electronic devices, M Younger than 18 or older than 85. < 6 months post tumor resection.","No","18 Years","All","Milwaukee","53226","Wisconsin","Sara Pillay","United States",1,"no",-88.022002,43.04338,2023-08-25 -"49",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Aachen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"48",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Aachen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1245,7 +1222,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Aachen","52074",NA,NA,"Germany",1,"no",6.083862,50.776351,2019-12-06 -"50",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Allensbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"49",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Allensbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1270,7 +1247,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Allensbach","78476",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"51",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Aibling NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"50",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Aibling NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1295,7 +1272,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Aibling","83209",NA,NA,"Germany",1,"no",12.009768,47.86405,2019-12-06 -"52",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Homburg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"51",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Homburg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1320,7 +1297,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Homburg","61348",NA,NA,"Germany",1,"no",8.618313,50.228032,2019-12-06 -"53",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Klosterlausnitz NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"52",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Klosterlausnitz NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1345,7 +1322,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Klosterlausnitz","07639",NA,NA,"Germany",1,"no",11.86817,50.916262,2019-12-06 -"54",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Sülze NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"53",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Sülze NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1370,7 +1347,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Sülze","18334",NA,NA,"Germany",1,"no",12.658113,54.111965,2019-12-06 -"55",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Berlin NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"54",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Berlin NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1395,7 +1372,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Berlin","10115",NA,NA,"Germany",1,"no",13.3888599,52.5170365,2019-12-06 -"56",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Gailingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"55",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Gailingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1420,7 +1397,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Gailingen","78262",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"57",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"56",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1445,7 +1422,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Greifswald","17475",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"58",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"57",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1470,7 +1447,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Greifswald","17491",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"59",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Göppingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"58",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Göppingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1495,7 +1472,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Göppingen","73035",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"60",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Heidelberg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"59",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Heidelberg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1520,7 +1497,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Heidelberg","69117",NA,NA,"Germany",1,"no",8.7112746,49.4121677,2019-12-06 -"61",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Kempen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"60",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Kempen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1545,7 +1522,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Kempen","47906",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"62",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Leipzig NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"61",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Leipzig NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1570,7 +1547,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Leipzig","04103",NA,NA,"Germany",1,"no",12.374733,51.340632,2019-12-06 -"63",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Lindlar NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"62",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Lindlar NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1595,7 +1572,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Lindlar","51789",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"64",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Marbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"63",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Marbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1620,7 +1597,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Marbach","71672",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"65",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Meerbusch NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"64",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Meerbusch NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1645,7 +1622,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Meerbusch","40670",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"66",52,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Vechta NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"65",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Vechta NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1670,7 +1647,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Vechta","49377",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"67",57,"Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia","Aphasia Apraxia of Speech","December 4, 2018","NCT05248295","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech are most helpful. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? A possible mechanism for this benefit is examined, by testing whether the degree of alignment of a person's speech with that of another speaker can account for unison benefit.","Aphasia is an acquired language disorder, most commonly due to stroke. It can affect an individual's ability to speak, understand spoken language, read, and write. Many treatments designed to improve spoken language in persons with aphasia (PWAs) use unison speech, having the person with aphasia speak along with the clinician or with a recording. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech help them the most. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? This knowledge is important because understanding who benefits from this commonly used and potentially powerful therapy component, under which conditions they benefit, and why they do, is critical for customizing therapy so it can be as effective and efficient as possible. Unison speech is conducted using one of two different timing patterns: (1) a natural conversational pattern, which is used in everyday conversations, or (2) a metrical pattern, which follows a beat-based timing framework, as in songs or some poems. In either case, precisely aligning one's speech with that of another person (i.e., entraining one's speech) requires prediction: each speaker must plan their own speech motor commands before having heard the other speaker say the words they are planning. Natural conversational timing requires the speaker to make use of knowledge about language, particularly grammar, to align with the other person. In contrast, a metrical pattern allows a speaker to predict speech timing without relying heavily on language-based knowledge. Given that many PWAs have impaired grammar, we hypothesize that most PWAs will benefit more from speaking in unison to sentences with metrical vs. conversational timing patterns. However, there is great variation in linguistic, motor speech, and timing skills across PWAs, so metrical and conversational timing patterns are likely to have different degrees of effectiveness for different individuals. Results from this study will demonstrate how individual characteristics and speech timing affect whether or not a person with aphasia benefits from speaking in unison. Results will also indicate whether a speaker's ability to predict speech timing is necessary for a benefit of unison speech. Prediction ability will be measured by how closely the speaker aligns their speech with a spoken model.","","Interventional","Inclusion Criteria: +"66",56,"Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia","Aphasia Apraxia of Speech","December 4, 2018","NCT05248295","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech are most helpful. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? A possible mechanism for this benefit is examined, by testing whether the degree of alignment of a person's speech with that of another speaker can account for unison benefit.","Aphasia is an acquired language disorder, most commonly due to stroke. It can affect an individual's ability to speak, understand spoken language, read, and write. Many treatments designed to improve spoken language in persons with aphasia (PWAs) use unison speech, having the person with aphasia speak along with the clinician or with a recording. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech help them the most. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? This knowledge is important because understanding who benefits from this commonly used and potentially powerful therapy component, under which conditions they benefit, and why they do, is critical for customizing therapy so it can be as effective and efficient as possible. Unison speech is conducted using one of two different timing patterns: (1) a natural conversational pattern, which is used in everyday conversations, or (2) a metrical pattern, which follows a beat-based timing framework, as in songs or some poems. In either case, precisely aligning one's speech with that of another person (i.e., entraining one's speech) requires prediction: each speaker must plan their own speech motor commands before having heard the other speaker say the words they are planning. Natural conversational timing requires the speaker to make use of knowledge about language, particularly grammar, to align with the other person. In contrast, a metrical pattern allows a speaker to predict speech timing without relying heavily on language-based knowledge. Given that many PWAs have impaired grammar, we hypothesize that most PWAs will benefit more from speaking in unison to sentences with metrical vs. conversational timing patterns. However, there is great variation in linguistic, motor speech, and timing skills across PWAs, so metrical and conversational timing patterns are likely to have different degrees of effectiveness for different individuals. Results from this study will demonstrate how individual characteristics and speech timing affect whether or not a person with aphasia benefits from speaking in unison. Results will also indicate whether a speaker's ability to predict speech timing is necessary for a benefit of unison speech. Prediction ability will be measured by how closely the speaker aligns their speech with a spoken model.","","Interventional","Inclusion Criteria: Native-speaker fluency in American English (prior to stroke for people with aphasia) Controls must report no history of speech, language, neurological disorders, or stroke @@ -1682,7 +1659,7 @@ Inadequate hearing ability to reliably complete task: fail hearing screen Inadequate cognitive ability to understand and remember task: fail cognition screening (different measures for controls and people with aphasia) Inadequate speech repetition ability to complete task, or to be considered a control: fail speech repetition screening (different thresholds for controls and people with aphasia) Inadequate auditory comprehension ability to understand task: fail auditory comprehension screen (people with aphasia only)","Accepts Healthy Volunteers","18 Years","All","Boston","02129","Massachusetts","Lauryn Zipse, Ph.D., CCC-SLP","United States",1,"no",-71.0537615,42.3756115,2018-12-04 -"68",59,"Individualized Precision rTMS for Language Recovery in Patients After Ischemic Stroke: a Multi-center RCT","Stroke, Ischemic Aphasia","June 5, 2023","NCT05842304","Changping Laboratory Beijing NA China","Changping Laboratory","Recruiting","The current multi-center study aims to evaluate the efficacy and safety of pBFS-guided rTMS Neuromodulation Treatment for the rehabilitation of language functions in ischemic stroke aphasic patients.","Increasing evidence suggests that rTMS has been effective in treating various psychological and neurological diseases, including treating post-stroke symptoms. Using the personalized brain functional sectors (pBFS) technique, we could precisely identify individualized brain functional networks and the personalized language-related stimulation site based on the resting-state functional MRI data. The current study proposes to conduct a multi-center, double-blinded, randomized and parallel controlled design trial, to investigate the efficacy and safety of pBFS-guided personalized TMS intervention in post-stroke aphasic patients. +"67",58,"Individualized Precision rTMS for Language Recovery in Patients After Ischemic Stroke: a Multi-center RCT","Stroke, Ischemic Aphasia","June 5, 2023","NCT05842304","Changping Laboratory Beijing NA China","Changping Laboratory","Recruiting","The current multi-center study aims to evaluate the efficacy and safety of pBFS-guided rTMS Neuromodulation Treatment for the rehabilitation of language functions in ischemic stroke aphasic patients.","Increasing evidence suggests that rTMS has been effective in treating various psychological and neurological diseases, including treating post-stroke symptoms. Using the personalized brain functional sectors (pBFS) technique, we could precisely identify individualized brain functional networks and the personalized language-related stimulation site based on the resting-state functional MRI data. The current study proposes to conduct a multi-center, double-blinded, randomized and parallel controlled design trial, to investigate the efficacy and safety of pBFS-guided personalized TMS intervention in post-stroke aphasic patients. Subjects will be randomly assigned to the following two groups: active continuous TBS (cTBS) group, or a sham control group. The allocation ratio will be 2:1. Subjects will receive a 3-week treatment for 21 consecutive days. The stimulation procedure will be assisted with real-time neuronavigation to ensure its precision.","","Interventional","Inclusion Criteria: @@ -1711,7 +1688,7 @@ History of alcohol, drug, and/or other abuse. Patients with other test abnormalities judged by the investigator to be unsuitable for the trial. Women of childbearing age who are pregnant or preparing for pregnancy. Patients who are participating in other clinical research trials.","No","35 Years","All","Beijing",NA,NA,NA,"China",1,"no",116.225091,40.219646,2023-06-05 -"69",63,"Treatment Outcomes With tDCS in Post-Stroke Aphasia","Aphasia","September 3, 2019","NCT03929432","University of Arkansas Little Rock Arkansas United States","University of Arkansas","Recruiting","The purpose this study is to test the utility of pairing external neuromodulation with behavioral language treatment to boost therapy outcomes and to investigate the mechanisms associated with recovery. Because all PWA have word retrieval deficits, this project will test if greater language gains can be achieved by supplementing anomia intervention with excitatory brain stimulation to the left hemisphere and will evaluate associated functional brain changes to aid the optimization of neural reorganization to facilitate language processing.","Aphasia is a language impairment that commonly occurs following brain damage (e.g., stroke). While language rehabilitation can yield improved language functioning, treatment outcomes vary greatly across individuals. In chronic aphasia, language gains occur through the brain's inherent ability to reorganize (i.e., neuroplasticity). +"68",62,"Treatment Outcomes With tDCS in Post-Stroke Aphasia","Aphasia","September 3, 2019","NCT03929432","University of Arkansas Little Rock Arkansas United States","University of Arkansas","Recruiting","The purpose this study is to test the utility of pairing external neuromodulation with behavioral language treatment to boost therapy outcomes and to investigate the mechanisms associated with recovery. Because all PWA have word retrieval deficits, this project will test if greater language gains can be achieved by supplementing anomia intervention with excitatory brain stimulation to the left hemisphere and will evaluate associated functional brain changes to aid the optimization of neural reorganization to facilitate language processing.","Aphasia is a language impairment that commonly occurs following brain damage (e.g., stroke). While language rehabilitation can yield improved language functioning, treatment outcomes vary greatly across individuals. In chronic aphasia, language gains occur through the brain's inherent ability to reorganize (i.e., neuroplasticity). While Speech-language therapy (SLT) can target various language skills and modalities, the most pervasive deficit across all persons with aphasia (PWA) is difficulty with word finding. Thus, aphasia treatment often includes some form of intervention focused on improving naming abilities. As with language function in general, naming abilities in PWA seems to be associated with left hemisphere recruitment, particularly with the viable tissue at the rim of the lesion (perilesional areas). This project investigates an innovative approach to improving current therapy by examining the benefits of using excitatory transcranial direct current stimulation (tDCS) stimulation/neuromodulation during anomia treatment (i.e. word-finding treatment). @@ -1738,7 +1715,7 @@ Co-occurring history of neurological disease/disorder/injury (e.g., traumatic br Co-occurring history of a major mental illness (e.g., schizophrenia, drug addiction, bipolar) Clinical conditions contraindicated for MRI or tDCS (e.g., implanted electrical devices, claustrophobia, seizure disorder) Positive pregnancy test (for females)","No","18 Years","All","Little Rock","72205","Arkansas",NA,"United States",1,"no",-92.3396525,34.7224165,2019-09-03 -"70",74,"Transcranial Alternating Current Stimulation (tACS) in Aphasia","Aphasia Stroke","January 4, 2020","NCT04375722","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States (NIH-NIDCD, 2015). Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits by providing brain stimulation concurrent with therapies. Transcranial direct current stimulation (tDCS) is one of the most widely used such technique. While tDCS has had relative success in chronic aphasia (>6 months after stroke), it has not been efficacious during subacute stages (<3 months after stroke). But enhancing language recovery early after stroke is desirable because of its potential impact on long-term language outcomes and quality-of-life. +"69",72,"Transcranial Alternating Current Stimulation (tACS) in Aphasia","Aphasia Stroke","January 4, 2020","NCT04375722","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States (NIH-NIDCD, 2015). Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits by providing brain stimulation concurrent with therapies. Transcranial direct current stimulation (tDCS) is one of the most widely used such technique. While tDCS has had relative success in chronic aphasia (>6 months after stroke), it has not been efficacious during subacute stages (<3 months after stroke). But enhancing language recovery early after stroke is desirable because of its potential impact on long-term language outcomes and quality-of-life. The current study will investigate the efficacy of high-definition tACS (HD-tACS) to help restore neural oscillatory activity in aphasia. TACS differs from tDCS in that sinusoidal, alternating currents are delivered rather than constant currents. TACS can manipulate the ongoing oscillatory neuronal activity and potentially increase functional synchronization (or connectivity) between targeted areas. This feature of tACS is quite attractive, given the new body of evidence suggesting that language impairments stem from diminished functional connectivity and disruptions in the language network due to stroke. The selection of tACS frequencies in this study is guided by our preliminary work examining pathological neural oscillations found near stroke-lesioned areas (or perilesional) in aphasia. By exogenously tuning the perilesional oscillations with tACS, the investigators hope to up-regulate communication across these areas and other connected areas to improve language outcome. If successful, tACS will be a powerful and novel treatment approach with reverberating positive impact on long-term recovery. @@ -1770,7 +1747,7 @@ Any metal implants in the skull Contraindications to MRI or tACS History of seizures History of dyslexia or other developmental learning disabilities","Accepts Healthy Volunteers","18 Years","All","Milwaukee","53226","Wisconsin","Priyanka Shah-Basak, PhD","United States",1,"no",-88.022002,43.04338,2020-01-04 -"71",79,"Treatment of Grammatical Time Marking in Post-Stroke Aphasia","Brain Injury, Vascular Aphasia Stroke","December 30, 2022","NCT05656638","University of Neuchatel Neuchâtel NA Switzerland","University of Neuchatel","Recruiting","The study aims to assess a individual or group therapy's effectiveness in grammatical time marking. The main objective is to examine whether the therapy improves grammatical time marking of inflected verbs treated on the sessions. We also explore whether the observed progress can be transferred to untrained items, more ecological contexts and if is maintained two and four weeks after the end of treatment. +"70",77,"Treatment of Grammatical Time Marking in Post-Stroke Aphasia","Brain Injury, Vascular Aphasia Stroke","December 30, 2022","NCT05656638","University of Neuchatel Neuchâtel NA Switzerland","University of Neuchatel","Recruiting","The study aims to assess a individual or group therapy's effectiveness in grammatical time marking. The main objective is to examine whether the therapy improves grammatical time marking of inflected verbs treated on the sessions. We also explore whether the observed progress can be transferred to untrained items, more ecological contexts and if is maintained two and four weeks after the end of treatment. This therapy will be administered to nine individuals with brain lesions after stroke. Five individuals will take part of the individual therapy and four individuals will take part of the group therapy (two individuals per group). The therapy will last one month, at the rate of three weekly sessions of approximately one hour.",NA,"","Interventional","Inclusion Criteria: @@ -1787,7 +1764,7 @@ Have significant impairments in oral/written comprehension. Present apraxia of speech or a severe arthritic disorder Present hemineglect Present impaired judgment and discernment, objectified by a neuropsychological evaluation","No","18 Years","All","Neuchâtel","2000",NA,"Marion Fossard","Switzerland",1,"no",6.931074,46.993392,2022-12-30 -"72",82,"Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia","Stroke Aphasia Apraxia of Speech","July 22, 2020","NCT04816799","Arizona State University Tempe Arizona United States","Arizona State University","Recruiting","A stratified, parallel-group, double-blind, randomized controlled trial of remotely delivered START treatment to individuals with severe-to-moderate stroke (with recruitment focused on individuals with low SES) will be conducted. Subjects and assessors will be blinded to the condition making the experiment double blind. Specifically, subjects will be told that we are exploring a new therapy that using different sounds to improve therapy. Parallel group design will ensure that subjects in the Control group are unaware that their ""sounds"" are softer than the START group. Trainers may become aware that a loud sound is present thus a unique Assessor will evaluate clinical performance before and after training making the study double-blind. Fifty-four subjects will undergo baseline testing in the laboratory to establish their capacity for functional and expressive speech as well as their self-reported health-related quality of life (power analysis below). Next, subjects will participate in a high-frequency, word-picture verification/ auditory-repetition treatment, 2 hr/day for 5 consecutive days focusing on expression of words of functional significance (e.g., water, fall). Subjects will either receive training with START or without (Control). Subjects will be re-tested immediately following training as well as one-month post to assess retention. Aim 1 will evaluate capacity of START to enhance SLT outcomes by assessing the % change in clinical assessment of functional and expressive speech. Our preliminary data points to a robust response [details]. Aim 2 will focus on the capacity of these changes to 1) be retained and 2) impact subject's reported quality of life. NOTE: While we are planning in-person baseline, end, and retention testing, in response to COVID, we have established remote clinical screening using peer-reviewed validated techniques for WAB and ABA-2 (see Alternative Solutions). All preliminary data collected for this proposal were collected remotely via no-contact protocols.",NA,"","Interventional","Inclusion Criteria: +"71",80,"Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia","Stroke Aphasia Apraxia of Speech","July 22, 2020","NCT04816799","Arizona State University Tempe Arizona United States","Arizona State University","Recruiting","A stratified, parallel-group, double-blind, randomized controlled trial of remotely delivered START treatment to individuals with severe-to-moderate stroke (with recruitment focused on individuals with low SES) will be conducted. Subjects and assessors will be blinded to the condition making the experiment double blind. Specifically, subjects will be told that we are exploring a new therapy that using different sounds to improve therapy. Parallel group design will ensure that subjects in the Control group are unaware that their ""sounds"" are softer than the START group. Trainers may become aware that a loud sound is present thus a unique Assessor will evaluate clinical performance before and after training making the study double-blind. Fifty-four subjects will undergo baseline testing in the laboratory to establish their capacity for functional and expressive speech as well as their self-reported health-related quality of life (power analysis below). Next, subjects will participate in a high-frequency, word-picture verification/ auditory-repetition treatment, 2 hr/day for 5 consecutive days focusing on expression of words of functional significance (e.g., water, fall). Subjects will either receive training with START or without (Control). Subjects will be re-tested immediately following training as well as one-month post to assess retention. Aim 1 will evaluate capacity of START to enhance SLT outcomes by assessing the % change in clinical assessment of functional and expressive speech. Our preliminary data points to a robust response [details]. Aim 2 will focus on the capacity of these changes to 1) be retained and 2) impact subject's reported quality of life. NOTE: While we are planning in-person baseline, end, and retention testing, in response to COVID, we have established remote clinical screening using peer-reviewed validated techniques for WAB and ABA-2 (see Alternative Solutions). All preliminary data collected for this proposal were collected remotely via no-contact protocols.",NA,"","Interventional","Inclusion Criteria: 18 years old Native English Speakers @@ -1801,7 +1778,7 @@ Corrected pure tone threshold (octave frequencies 250- 4000 Hz) norms for their Exclusion Criteria: Severe concurrent uncontrolled medical problems (e.g. cardiorespiratory impairment).","No","18 Years","All","Tempe","85287","Arizona","Claire Honeycutt","United States",1,"no",-111.932727,33.416893,2020-07-22 -"73",85,"tDCS Effects on Brain Plasticity in Aphasia Treatment","Aphasia Stroke","November 1, 2021","NCT05483556","The Hong Kong Polytechnic University Kowloon NA Hong Kong","The Hong Kong Polytechnic University","Recruiting","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI. +"72",83,"tDCS Effects on Brain Plasticity in Aphasia Treatment","Aphasia Stroke","November 1, 2021","NCT05483556","The Hong Kong Polytechnic University Kowloon NA Hong Kong","The Hong Kong Polytechnic University","Recruiting","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI. This randomized, placebo-controlled, double-blinded pilot study will recruit ten chronic stroke patients with Broca's Aphasia randomly assigned either to sham or an anodal tDCS groups. Following speech and language assessment, all the participants will receive 20 minutes of individualized language therapy daily for ten days in two consecutive weeks. Simultaneously, the treatment group will receive 20 minutes of 2mA anodal HD-tDCS over the left IFG, while the sham group will receive the 30s of 2mA anodal HD-tDCS. Structural, resting state and task activated functional MRI will be performed. Data acquisition will be performed before, immediately after and two months after the treatment. @@ -1822,7 +1799,7 @@ Wernicke's aphasia and other speech disorders, degenerative, psychiatric or meta Deaf, blind, pregnant/ or preparing for pregnancy, cognitive issues, tattoos Have cochlear implants, pacemaker, surgical nails for bone fracture, artificial joints, dental braces, dentures Taking anti-depressant medications","No","18 Years","All","Kowloon",NA,NA,"Dr Min Wong","Hong Kong",1,"no",114.179821,22.3046025,2021-11-01 -"74",87,"Effects of Verb Network Strengthening Treatment (VNeST) on Word Finding in Aphasia","Anomia Aphasia Stroke","January 16, 2022","NCT05152979","Göteborg University Gothenburg Västra Götaland Sweden","Göteborg University","Recruiting","Although there is evidence that speech-language therapy may improve speech in language disorders following left hemisphere stroke there is still a lack of evidence for which types of therapy are effective. Furthermore, in Sweden, as well as in several other countries, access to speech-language therapy is limited. The purpose of this clinical trial is to compare outcome from Verb Network Strengthening Treatment (VNeST) provided as In-Clinic therapy (I-CT) or as synchronous telepractice therapy (TP-T).","Every year thousands of persons in Sweden suffer from brain damage resulting in anomia, that is, word finding difficulties affecting their ability to talk to other people. Anomia is one of the most common and persistent symptoms of aphasia following a left hemisphere stroke, but it is also common in in progressive neurological diseases such as Parkinson's disease or multiple sclerosis (MS). There is evidence that more intensive speech language therapy may improve speech even in a chronic (> six month post stroke) phase of aphasia. However, access to the necessary amount of speech language therapy is limited due to lack of financial resources as well as to limitations to service providers in more rural areas. +"73",85,"Effects of Verb Network Strengthening Treatment (VNeST) on Word Finding in Aphasia","Anomia Aphasia Stroke","January 16, 2022","NCT05152979","Göteborg University Gothenburg Västra Götaland Sweden","Göteborg University","Recruiting","Although there is evidence that speech-language therapy may improve speech in language disorders following left hemisphere stroke there is still a lack of evidence for which types of therapy are effective. Furthermore, in Sweden, as well as in several other countries, access to speech-language therapy is limited. The purpose of this clinical trial is to compare outcome from Verb Network Strengthening Treatment (VNeST) provided as In-Clinic therapy (I-CT) or as synchronous telepractice therapy (TP-T).","Every year thousands of persons in Sweden suffer from brain damage resulting in anomia, that is, word finding difficulties affecting their ability to talk to other people. Anomia is one of the most common and persistent symptoms of aphasia following a left hemisphere stroke, but it is also common in in progressive neurological diseases such as Parkinson's disease or multiple sclerosis (MS). There is evidence that more intensive speech language therapy may improve speech even in a chronic (> six month post stroke) phase of aphasia. However, access to the necessary amount of speech language therapy is limited due to lack of financial resources as well as to limitations to service providers in more rural areas. It has been suggested that telepractice may increase the access to speech-language therapy for more people but there is a lack of knowledge of whether there is a difference in outcome from interventions provided as In-Clinic therapy (I-CT) or as telepractice therapy (TP-T). @@ -1844,7 +1821,7 @@ Moderately or severely impaired comprehension Moderate-severe apraxia of speech or dysarthria which may interfere with assessment Participation in any other speech-language treatment during the study Active substance dependence","No","18 Years","All","Gothenburg","40530","Västra Götaland",NA,"Sweden",1,"no",11.961307,57.6970935,2022-01-16 -"75",88,"Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia","Aphasia Non Fluent Stroke","May 5, 2022","NCT04433351","University Hospital, Grenoble Grenoble NA France","University Hospital, Grenoble","Recruiting","SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that aims first, to test and develop a novel speech rehabilitation program designed for patients with non-fluent aphasia and, second, to better describe neural reorganization after successful recovery. To this end, the investigators will conduct a prospective monocentric cross-over study, including two cohorts of post-stroke aphasic patients and two control groups.","In this project, the investigators propose to evaluate the effectiveness of a new rehabilitation program, based on illustration of speech articulators, to improve speech in patients with non-fluent aphasia. The instigators' method is based on the reinforcement of the interaction between perceptual and motor representations, thanks to the innovative Ultraspeech device. The investigators will exploit a fundamental psycholinguistic principle, which postulates that speech is based both on the activation of the system controlling the motricity of effectors related to word articulation (action) and on the auditory or visual representation of words (perception). The sensory-motor interaction method that the investigators propose allows the patient to perceive phonemes and visualize on a computer screen the movements of the tongue and lips previously recorded by a healthy speaker, typically a speech therapist. Through repeated exercises, the patient is trained to produce sounds correctly, using the correct pronunciation and articulatory movements of the reference speaker as a model. The investigators will compare patients who will follow a classical speech and language therapy rehabilitation program followed by an 'enriched' rehabilitation program including rehabilitation based on sensory-motor interaction associated with speech and language therapy, and vice versa. In order to judge the favorable effect of the rehabilitation program including sensory-motor integration, the following measures will be considered: (a) language skills, (b) phonemic quality, (c) inner speech abilities and (d) cognitive function. Brain language networks will be evaluated with neuroimaging.","post-stroke aphasia non-fluent aphasia speech rehabilitation neuroimaging neural reorganization recovery","Interventional","Inclusion Criteria: +"74",86,"Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia","Aphasia Non Fluent Stroke","May 5, 2022","NCT04433351","University Hospital, Grenoble Grenoble NA France","University Hospital, Grenoble","Recruiting","SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that aims first, to test and develop a novel speech rehabilitation program designed for patients with non-fluent aphasia and, second, to better describe neural reorganization after successful recovery. To this end, the investigators will conduct a prospective monocentric cross-over study, including two cohorts of post-stroke aphasic patients and two control groups.","In this project, the investigators propose to evaluate the effectiveness of a new rehabilitation program, based on illustration of speech articulators, to improve speech in patients with non-fluent aphasia. The instigators' method is based on the reinforcement of the interaction between perceptual and motor representations, thanks to the innovative Ultraspeech device. The investigators will exploit a fundamental psycholinguistic principle, which postulates that speech is based both on the activation of the system controlling the motricity of effectors related to word articulation (action) and on the auditory or visual representation of words (perception). The sensory-motor interaction method that the investigators propose allows the patient to perceive phonemes and visualize on a computer screen the movements of the tongue and lips previously recorded by a healthy speaker, typically a speech therapist. Through repeated exercises, the patient is trained to produce sounds correctly, using the correct pronunciation and articulatory movements of the reference speaker as a model. The investigators will compare patients who will follow a classical speech and language therapy rehabilitation program followed by an 'enriched' rehabilitation program including rehabilitation based on sensory-motor interaction associated with speech and language therapy, and vice versa. In order to judge the favorable effect of the rehabilitation program including sensory-motor integration, the following measures will be considered: (a) language skills, (b) phonemic quality, (c) inner speech abilities and (d) cognitive function. Brain language networks will be evaluated with neuroimaging.","post-stroke aphasia non-fluent aphasia speech rehabilitation neuroimaging neural reorganization recovery","Interventional","Inclusion Criteria: patients with late sub-acute and chronic post-stroke (> 4 months) non-fluent aphasia after lesion in the dominant hemisphere for language native speakers of French @@ -1854,7 +1831,7 @@ satisfying all criteria for the MRI examination Exclusion Criteria: patients with comprehension deficits, hemi-spatial neglect or upper limb apraxia","No","55 Years","All","Grenoble","38043",NA,NA,"France",1,"no",5.735782,45.18756,2022-05-05 -"76",89,"Effects of Transcranial Direct Current Stimulation (tDCS) on Language","Stroke Aphasia","December 1, 2019","NCT04166513","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). +"75",87,"Effects of Transcranial Direct Current Stimulation (tDCS) on Language","Stroke Aphasia","December 1, 2019","NCT04166513","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). This study will examine the effects of tDCS during speech therapy to further examine which method or methods is best for patient recovery. Patients enrolled in the study will undergo language testing that covers a broad range of language functions. Functional Magnetic Resonance Imaging (fMRI) will be completed before and after speech therapy intervention arms to investigate the neural processes affected by tDCS and speech therapy. @@ -1872,7 +1849,7 @@ Advanced neurodegenerative disease (i.e. Stage 3 Alzheimer's disease) or neurolo Severe psychopathology (e.g. schizophrenia, bipolar disorder, acute major depressive episode) No suspected or diagnosed uncorrectable hearing or vision difficulties, or developmental disabilities (i.e. intellectual disability or learning disability). Contraindications to MRI such as claustrophobia, implanted electronic devices, MRI-incompatible metal in the body, extreme obesity, pregnancy, inability to lie flat, and inability to see or hear stimulus materials","No","18 Years","All","Milwaukee","53226","Wisconsin","Sara Pillay","United States",1,"no",-88.022002,43.04338,2019-12-01 -"77",90,"Intention Treatment for Anomia","Aphasia Stroke","May 24, 2021","NCT04267198","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia). Stroke-induced aphasia results in increased healthcare costs and decreased quality of life. As the population of Veterans continues to age, there will be an increasing number for Veterans living with the aphasia and its consequences. Those Veterans deserve to receive aphasia treatment designed to facilitate the best possible outcomes. In the proposed study, the investigators will investigate optimal treatment intensity and predictors of treatment response for a novel word retrieval treatment. The knowledge the investigators gain will have direct implications for the selecting the right treatment approach for the right Veteran.","Difficulty retrieving words is one of the most common language complaints in individuals with stroke-induced aphasia. The negative consequences related to word retrieval impairment include increased health care costs and decreased quality of life. A variety of treatment approaches exist to improve word retrieval, and most of the treatments result in immediate improvement on trained words. However, long-term improvement and improvement on untrained words or behaviors is less common. Additionally, the investigators currently know very little about optimal treatment administration parameters, and the investigators know even less about predictors of treatment response. To make the best use of the limited clinical resources available for aphasia treatment, and to maximize outcomes for Veterans with aphasia, the investigators must: 1) develop clinically translatable treatments that yield widespread and lasting effects and 2) develop clinically accessible ways of identifying who will acquire benefit from a specific treatment approach. This study takes on these two challenges by investigating dose frequency (massed vs. distributed practice) effects and by identifying the language, cognitive and neural predictors of response to Intention treatment (INT), a novel word retrieval treatment. Specifically, the investigators will address the following aims: +"76",88,"Intention Treatment for Anomia","Aphasia Stroke","May 24, 2021","NCT04267198","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia). Stroke-induced aphasia results in increased healthcare costs and decreased quality of life. As the population of Veterans continues to age, there will be an increasing number for Veterans living with the aphasia and its consequences. Those Veterans deserve to receive aphasia treatment designed to facilitate the best possible outcomes. In the proposed study, the investigators will investigate optimal treatment intensity and predictors of treatment response for a novel word retrieval treatment. The knowledge the investigators gain will have direct implications for the selecting the right treatment approach for the right Veteran.","Difficulty retrieving words is one of the most common language complaints in individuals with stroke-induced aphasia. The negative consequences related to word retrieval impairment include increased health care costs and decreased quality of life. A variety of treatment approaches exist to improve word retrieval, and most of the treatments result in immediate improvement on trained words. However, long-term improvement and improvement on untrained words or behaviors is less common. Additionally, the investigators currently know very little about optimal treatment administration parameters, and the investigators know even less about predictors of treatment response. To make the best use of the limited clinical resources available for aphasia treatment, and to maximize outcomes for Veterans with aphasia, the investigators must: 1) develop clinically translatable treatments that yield widespread and lasting effects and 2) develop clinically accessible ways of identifying who will acquire benefit from a specific treatment approach. This study takes on these two challenges by investigating dose frequency (massed vs. distributed practice) effects and by identifying the language, cognitive and neural predictors of response to Intention treatment (INT), a novel word retrieval treatment. Specifically, the investigators will address the following aims: Aim 1: To investigate dose frequency effects on maintenance and generalization of INT gains. Outcome measure: Word retrieval accuracy for trained and untrained words. @@ -1891,7 +1868,7 @@ Exclusion Criteria: Severe apraxia of speech or dysarthria Clinically significant depression For MRI safety: implanted medical devices, metal in the body and claustrophobia.","No","21 Years","All","Decatur","30033-4004","Georgia",NA,"United States",1,"no",-84.296069,33.773758,2021-05-24 -"78",92,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. +"77",91,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. All enrolled participants will be assessed on their mood, past music experience and music genre preference (music therapy assessment). They will complete the abridged Beck (BDI-2-fastscreen) questionnaire, the stoke and aphasia quality of life scale; a Likert which measures distress; the Western Aphasia Battery (WAB); the NIH Stroke Scale (SS); the Figely compassion scale; and the driving scene test (Stern and White); and the Rankin. In additional we will take saliva samples from all participants to measure hormone levels. @@ -1902,19 +1879,7 @@ Stroke victim, regardless of level of stroke Exclusion Criteria: None","No","18 Years","All","New York","10003","New York","Joanne Loewy","United States",1,"no",-73.953275,40.7898205,2014-04-04 -"79",99,"Home Program Practice for People With Language Disorders After Stroke","Aphasia Stroke","January 22, 2021","NCT04543084","Duquesne University Pittsburgh Pennsylvania United States","Duquesne University","Recruiting","Logbooks are one of the most commonly used methods to both support and track adherence in research studies. This study will look at using logbooks to support adherence to reading practice for individuals with post-stroke aphasia. It is thought that using a logbook will increase practice time.",NA,"","Interventional","Inclusion Criteria: - -at least 6 months post left hemisphere stroke with a diagnosis of aphasia -must have self-reported interest in working to improve reading comprehension -access to the Internet -speak English as a primary language - -Exclusion Criteria: - -significant visual or hearing impairment as determined by ""aphasia-friendly"" and age-appropriate screening -actively receiving speech-language pathology services in which computerized or reading comprehension home practice activities are assigned/requested -severe auditory comprehension impairment that limits understanding of one-step directions (i.e., Western Aphasia Battery-Revised sequential commands subtest score below 8).","No","18 Years","All","Pittsburgh","15228","Pennsylvania",NA,"United States",1,"no",-79.991974,40.4375005,2021-01-22 -"80",100,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: +"78",98,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: Stroke Survivors: @@ -1939,7 +1904,7 @@ Additional Exclusion Criteria for MRIs: Pacemaker or magnetic metal in the body that is not MRI compatible Pregnancy Claustrophobia","Accepts Healthy Volunteers","18 Years","All","Washington","20057","District of Columbia",NA,"United States",1,"no",-77.078807,38.911961,2018-11-01 -"81",102,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: +"79",100,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: Diagnosis of aphasia secondary to stroke and presence of naming deficits (at least 20% errors on the Boston Naming Test or Hopkins Action Naming Assessment) Capable of giving informed consent or indicating another to provide informed consent @@ -1953,7 +1918,7 @@ Lack of English proficiency (by self/legally authorized representative report) Prior history of neurologic disease affecting the brain (e.g., brain tumor, multiple sclerosis, traumatic brain injury) other than stroke Prior history of severe psychiatric illness, developmental disorders or intellectual disability (e.g., PTSD, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders) Uncorrected severe visual loss or hearing loss by self-report and medical records","No","18 Years","All","Baltimore","21287","Maryland",NA,"United States",1,"no",-76.6204945,39.3289375,2023-05-31 -"82",104,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. +"80",102,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. However, language processes are not determined solely by local neural activity at a single site, but rather by the interaction between neural networks. This is because a large cortical network is involved in language processes and, therefore, the same language disorder may result from lesions at different locations in this network. @@ -1979,7 +1944,7 @@ Impaired alertness or delirium Severe co-morbidity affecting speech Contraindication to tDCS: pregnant women, patients with active implants such as pacemakers or cochlear implants, patients with one or more seizures, metal objects in the brain Occurrence of a new stroke during the study protocol.","No","18 Years","All","Geneva","1211","GE","Adrian Guggisberg","Switzerland",1,"no",6.1486155,46.1937405,2022-10-24 -"83",110,"Prism Adaptation in Left Brain Stroke","Aphasia Spatial Neglect Stroke","February 15, 2021","NCT04387162","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Of the 15,000 Veterans who are hospitalized for stroke each year more than half experience spatial and motor impairments and pain. Spatial-motor-sensory problems limit functioning and independence, which is costly to Veterans, their families, and society. Currently, spatial-motor-sensory problems are targeted using different treatments. However, there is a treatment that has shown promise in simultaneously targeting spatial function, motor function and pain in right-brain stroke. The investigators propose to investigate the feasibility of using adapted spatial-motor sensory assessment and treatment procedures for Veterans with left-brain stroke who have language and cognitive impairment. The next step will be to conduct a large-scale study focused on this multi-target treatment for more efficient and effective stroke rehabilitation. The investigators expect this line of research to increase functioning, independence and quality of life in Veteran stroke survivors.","The functional disability experienced by Veterans after stroke, and the limited rehabilitation resources available, highlight the importance of identifying feasible treatments acting on more than one recovery target. Currently, there are separate and modality-specific treatment pathways for cognitive and motor impairments. These modality-specific treatment pathways lead to fragmentation of care, and under-identification and under-treatment of invisible disabilities, such as spatial neglect, aphasia and pain. The result is longer hospital stays, greater risk of falls, and poor functional outcomes. Employing a treatment that simultaneously addresses multiple targets will ensure that the investigators provide the needed care for >50% of post-stroke Veterans who have both visible and invisible disabilities, during the critical post-acute period of recovery. +"81",108,"Prism Adaptation in Left Brain Stroke","Aphasia Spatial Neglect Stroke","February 15, 2021","NCT04387162","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Of the 15,000 Veterans who are hospitalized for stroke each year more than half experience spatial and motor impairments and pain. Spatial-motor-sensory problems limit functioning and independence, which is costly to Veterans, their families, and society. Currently, spatial-motor-sensory problems are targeted using different treatments. However, there is a treatment that has shown promise in simultaneously targeting spatial function, motor function and pain in right-brain stroke. The investigators propose to investigate the feasibility of using adapted spatial-motor sensory assessment and treatment procedures for Veterans with left-brain stroke who have language and cognitive impairment. The next step will be to conduct a large-scale study focused on this multi-target treatment for more efficient and effective stroke rehabilitation. The investigators expect this line of research to increase functioning, independence and quality of life in Veteran stroke survivors.","The functional disability experienced by Veterans after stroke, and the limited rehabilitation resources available, highlight the importance of identifying feasible treatments acting on more than one recovery target. Currently, there are separate and modality-specific treatment pathways for cognitive and motor impairments. These modality-specific treatment pathways lead to fragmentation of care, and under-identification and under-treatment of invisible disabilities, such as spatial neglect, aphasia and pain. The result is longer hospital stays, greater risk of falls, and poor functional outcomes. Employing a treatment that simultaneously addresses multiple targets will ensure that the investigators provide the needed care for >50% of post-stroke Veterans who have both visible and invisible disabilities, during the critical post-acute period of recovery. Prism adaptation treatment (PAT) is a 10-day regimen reported to be inexpensive, replicable and effective for treatment of spatial neglect, and studies have demonstrated that it also enhances everyday activities and motor recovery and reduces chronic post-stroke pain in patients with right brain stroke. Additionally, brain mapping methods have shown that in patients with right brain stroke, those with frontal lesions respond optimally to PAT. No studies have investigated PAT in left-brain stroke patients with language and cognitive impairment. To address this research gap, the investigators will address the following aims: @@ -1998,7 +1963,7 @@ able to provide informed consent to participate, using aphasia-accessible proces Exclusion Criteria: History of brain conditions other than left brain stroke, including clinical right brain pathology.","No","18 Years","All","Decatur","30033-4004","Georgia",NA,"United States",1,"no",-84.296069,33.773758,2021-02-15 -"84",115,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: +"82",113,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: Posterior cortical atrophy - a version of Alzheimer's disease with vision difficulties Logopenic variant primary progressive aphasia - a version of Alzheimer's disease with language difficulties @@ -2032,7 +1997,7 @@ Conditions precluding entry into the scanners (e.g. morbid obesity, claustrophob Exposure to research related radiation in the past year that, when combined with this study, would place subjects above the allowable limits. Participation in the last year in a clinical trial for a disease modifying drug for AD. Taking immunosuppressive medication (e.g., glucocorticoids, cytostatics, antibodies, drugs acting on immunophilins, interferons, tumor necrosis factor inhibitors). Nonsteroidal anti-inflammatory drugs (NSAIDs) are not exclusionary.","Accepts Healthy Volunteers","50 Years","All","New York","10032","New York","James M Noble, MD, MS, CPH, FAAN","United States",1,"no",-73.9622875,40.807223,2020-11-17 -"85",167,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: +"83",165,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: to evaluate the residual neuroplastic processes in DOC state related to music exposure to determine the putative modulation of the aforementioned processes and the clinical outcome of DOC patients by non-pharmacological strategies, i.e., electric (tDCS) and music stimulation @@ -2053,9 +2018,9 @@ No hystory of psychiatric disease Previous stroke use of alcohol and drugs premorbid dementia","No","18 Years","All","Bari","70025","Ba","Simona Spaccavento","Italy",1,"no",16.862029,41.125784,2022-09-01 -"86",NA,"Functional reorganization of the language and domain-general multiple demand systems in aphasia",NA,"March 1, 2022","manual1","Boston, MA","Boston University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Boston",NA,"Massachusetts","Swathi Kiran",NA,NA,"no",-71.058291,42.360253,2022-03-01 -"87",NA,"Characterizing inner speech in aphasia",NA,"March 9, 2022","manual2","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 -"88",NA,"Inner speech as a naming therapy predictor in aphasia",NA,"March 9, 2022","manual3","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 -"89",NA,"Measuring and understanding the experience of post-traumatic growth in aphasia",NA,"March 9, 2022","manual4","Reno, NV","University of Nevada Reno",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Reno",NA,"Nevada","Tami Brancamp",NA,NA,"Online",-119.812658,39.526121,2022-03-09 -"90",NA,"Reading in Aphasia",NA,"January 1, 2020","manual5","Atlanta, GA","Georgia State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Atlanta",NA,"GA","Rachael Harrington",NA,NA,"Online",-84.390264,33.748992,2020-01-01 -"91",NA,"Assessment of anomia: Improving efficiency and utility using item response theory",NA,"August 31, 2020","manual6","Portland, OR","Portland State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Portland",NA,"OR","Gerasimos Fergadiotis",NA,NA,"no",-122.674195,45.520247,2020-08-31 +"84",NA,"Functional reorganization of the language and domain-general multiple demand systems in aphasia",NA,"March 1, 2022","manual1","Boston, MA","Boston University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Boston",NA,"Massachusetts","Swathi Kiran",NA,NA,"no",-71.058291,42.360253,2022-03-01 +"85",NA,"Characterizing inner speech in aphasia",NA,"March 9, 2022","manual2","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 +"86",NA,"Inner speech as a naming therapy predictor in aphasia",NA,"March 9, 2022","manual3","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 +"87",NA,"Measuring and understanding the experience of post-traumatic growth in aphasia",NA,"March 9, 2022","manual4","Reno, NV","University of Nevada Reno",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Reno",NA,"Nevada","Tami Brancamp",NA,NA,"Online",-119.812658,39.526121,2022-03-09 +"88",NA,"Reading in Aphasia",NA,"January 1, 2020","manual5","Atlanta, GA","Georgia State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Atlanta",NA,"GA","Rachael Harrington",NA,NA,"Online",-84.390264,33.748992,2020-01-01 +"89",NA,"Assessment of anomia: Improving efficiency and utility using item response theory",NA,"August 31, 2020","manual6","Portland, OR","Portland State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Portland",NA,"OR","Gerasimos Fergadiotis",NA,NA,"no",-122.674195,45.520247,2020-08-31 diff --git a/docs/data/contact.rds b/docs/data/contact.rds index 251af2f2a8843edfba8d7b98a350047563c7e5cf..4203112611e6ccb9e43c4f790ad15845b2e4c5d5 100644 GIT binary patch delta 113 zcmX>T+8;bYmN9vwoHYC794^z%3)m}|Hk)wWV`NO;EX;F(WwN56*k(n+i;SDug#AE* zp&}7%o8L*LF>NlDodXn@tST?R*-$=_W%6ld;mxO&7c)+tqAIj_vMNaN9JLorlc#Iy PPd==OigYDy^s3j-$u1A{=jI+A}RTK`NjE3Mfv4v7AuKaBM@PXoz(c_~z+4JiQ!_&o0|Tg;+22i2N tYn9|T?^IgM$YyF{Y+zxs*)?MC$Cpz+q_wUkr~KfpUkZ)GTB;HVDf$CiplXRPe78B164l*m1e8SPcByz-dwK6 z%{+OxrZ5O^-mRI)G+AHg7|`TzI{IvzU5uZyY<97j&j=Jyuu^B9EN^>*arxvQw!44= So9*;iCjWGr1{9d!>yv)3Gg%TI%V1>lI6a{BbpAd!2JO#h}Jl(XM z($u_?$$Y#)lVy3GH_P%$@>sfhBQuc%;Z#swEQB4fYkhgoK%JI z%#sWRpTxZM(!}&s1((d?{Gyc9qTjqt7;Zh9N(vZ)RRzYH@x^ z;^YW(^~v$(3Lw0BuTd)thpe~F g=FGL#V-aKEWnf@n1mY+lhOvQ8a-0EFm*nIO0GugqH2?qr diff --git a/docs/data/location.rds b/docs/data/location.rds index ae605e799e233dcb12d6ce2427b48d47ffebf054..ec1801bff6ac94a3f8e863a0dd76397028035066 100644 GIT binary patch delta 88 zcmZqCe62n~meFpb++4=Z=NK0;Zf<7wVq~sm1vviJMn)od&5je_vu%0I(deC|E>C)_XG^~wCld%=-n z;fz{TS8f=_c~-$3R?9B3dUlyLuq&*QHL+`~m9?>U*2%irwDbvEII2XH=BbB)S02?L z`hvod=ggDpR$(2=v}wx5B2z}geq|r)5OShuhYt)Mp9U2xwuHQCedKY}_Ip*sDI3&q z$y31-)u(@=tck?9?2pX%sNXN&S<3zNBAn|O9wXN<0CAo;1MeL z17WhqF-KQE!MrdZNhGmc_a$*g(0URhbmlD%98~$Uc$;rXa0g==e~hK@5|6u6*bKCj z!T@c|AwNO;-s5wi>+|R%oyPrxDwDxqyf(Lhi-LxhFiIm!==Fv;SBL6nv5XR%;G;Jg z^dH71NTVO{9_OEpB1pR{cqbbLe}y1j_>A|nQT&fWu3}3zihoh))isQPSSGQ7@xPd& BuJ!-` delta 5457 zcmaJ_ZH!!18ScHeE$v`SYd^MpY!8i8nzCDgsS43T()bNCLzliD-}#J$AeD3Kb_7UbL|9(pOhb9==7nf*lJ~HQ+A(ayyc?U=1Wf6pIq7sRK9ghMvBNqO8*#{Q3e`Axhh6X468V@D!+KaV+N*`wj z0}fxNysyN86k+qRZM_QzdLA{J{XJWoZ*BV{EIohubLJ&`_Us)R9UNRZaMkt3>OG?) zgJYx3`+DEU?ZNG9R&DFK%agNkMMia|D(p7tc_LI1Ul_V(m$`YC01iAqHT z$N{tQrz9MQ2L)RN2t9Y0&!gHLud_Hr29p#2Fb3{s2q@#sS2!!S!^S#?NEB?AWoWB7 z2;l{yQG$i^W?d(qjzdUrg{uN`8UM<1R+eM#BsUp~5drrAr)1-9 zV{?O^De(Z@1kZ6~pHn&|fJqqcc81Q+%S1xNVHPGsMx>+XJdTXRJdfC%gb%yXiI~Frjz3! z$-W3|xI>bKI82V@+2m(+kS6^h$`g*10(x>3x5o0>z2OXV0qui5!U(`;09*%!c#u1Q zD)@*f*{ViFw!ysyqPmQ1%QB}O1~oKm>5Eq=aeIbE*i2g+=|}Xqlj)fwD+un=&bcrI9^d&^-NohG7E$EwbJgliWqTH86grB@3 zJG8i6hNk_57jnN_yV8=`NNExXsLOIPcR3reVRxeK^Y9=;v51k*B0J3OTBi00ttJ43 zba7=Fl@IvJ%5qo0vU6;7P=-C|SDv;9Q)RND-`LU6`k{lY*B04PqOJCsn9*iA)eGU3 zX}R7)J3u*te_F+sI78JQO3%w_I&kFSJ&Q+~2r2lkCif&j){&Xz^(KD-{t?8BawmEG z7GvxF3aS=^)52H4OqfTi;0Z8~Wn6a`f}*$tPg?1V3m=?*eS5>W_K2#Ml$rrXHK|An zQh`xm6j<&m4;3e-GLUMHma~!qRKnQzQKj@|2r6jE%NdsmH4p&71ME%!Mvp>F0vFnF zhMqYGu``3Z={n6IW~nRC%Z}}iMf?aTl_}+ZSC7?fh-)W`Yzjc7szv26!rzWjC}V22 zEul8708bqo6usiYW3QdvVvIk$?_6u&Ipd?+{#AdzD0i1L70@Cs7c`ksH)YjJ)}Ju9 zCBJ*$T+`6Ml2DL_BCbPYtd5ZAG_f0*14kmZ7tM_q)lecS;;|4R={$d*zq8m}oH-Edm zffh+newO(mZu$>+}d(ygJZ`;9XcGbjjd2c!Ws6)+d#iWu+uJ8kk!e#awO@sYuT; zeQ3IHXImk@KqClBoxXKE6JZtP*)0lm|2+Qd$9#ZFwP$`03sK%ZQ3w^E!C^xmcad&~ zI$Y2INT5~;aMPOA!4~%#xXaLYQ`6XCW}3UM@>CP941JQZ8`zNTf{>t=PTwfLwKJQE zB${XPnp&?;KSeYKnQ+kd!;WH%i{wIE<+C7ZGbs`^H>xq(WXhKw1;~S9YyA!8&Qh}WIcr^O^t8EgyD{FH{F(XT zC6}yRu@-aqHE_@=dG zcLx{C6g!8?718jA#HVtcYkunZPCyz!<0Z`a;4|b%_|!6ZG^A1iiv<-9*0lNuQP`i)rSC72pYE`(*?BAwRS%;}9lLg&Qpg7}W5QLQ zIKFjxqogqX_365yi!dD%AgX|E*qw}at#&1VLRrt}e7x;;12Nt?qHo0)smgJSyyZv zK$}IizPLgIYxO-k$H}Gdn^(7@Tdg1NPu`oidJLXS{L0*tyuR7$OUu>j%%r@D=iTys{JT&#jq^b*9WC%wbgmC1&;%(Ya-Q+Vjp(QHqM^wEn4m=GbE zx`^u3FF7Eq5sW+Sl(vkK1cav^fFoH|RQZ8G=&4qebJQ&aB02wox$PiAhZ$FEneN#f z=}L4Di`*fMAipS91<0!3#UVhyD2n;S7_!(XoQHYz<_He)2sA*a8JF~2h<7{i1n-E{ z92@J;&|t08XlM;QVr@j{*P3|JI&UOzJY|h1zoh>j_^$Oi`t%e;pX$`()J#D0`KmB9t>&6AY-un}4 g?!sT6e9`*G@?XXBA6B<6eZ|^q8gC>ATh@{P0VaB!RR910 diff --git a/docs/list_view.html b/docs/list_view.html index 1b39523..b97031b 100644 --- a/docs/list_view.html +++ b/docs/list_view.html @@ -6851,143 +6851,6 @@

-
- -


-
-
- -

Copy these email(s) into your email:

-

samargia@d.umn.edu, fencl003@umn.edu

-

Copy this email template into your email:

-
-Dear Sharyl Samargia-Grivette and Sydney Viel,

-I found your research on aphasiaresearch.org.
-I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
-The best way to contact me is:
-  Caregiver: [Insert your phone / email]
-  Person with aphasia: [Insert your phone / email]
-Thank you for doing this research.

-Sincerely,
-[Insert your name]

-
- -
- -
-
-
-

-Combining tDCS and CILT in Non-fluent Aphasia -

-
-Principle Investigator: NA -
-
-Institution: University of Minnesota -
-
-Country: United States -
-
-City: Duluth, Minnesota -
-
-Brief Description: -
-

The long-term goal of this work is to determine if combining a highly intensive, task-specific behavioral language intervention with modulation of the efferent cerebellar-cortical pathway using transcranial direct current stimulation (tDCS) has a positive influence on discourse, verbal fluency and working memory in individuals with non-fluent aphasia after stroke. And if these changes can be related to neuroplastic change in the cerebellar cortical pathway indirectly measured through neurophysiologic changes using spectral electroencephalogram (EEG). The initial phase includes the proposed pilot study data from which will be used to inform a larger clinical trial. The primary aims of this pilot are to 1) determine the effect of combining cerebellar tDCS with constraint-induced language therapy (CILT) on language as measured by a verbal fluency task and discourse task in a small population and 2) identify the tolerance of the intervention and barriers to participation measured by the adverse events questionnaire that will inform the methodology of a larger study. The secondary aims include estimating the size of the treatment effect on 1) delta percentage in F3, F7 and Fp1 compared to F4, F8, and Fp2 using resting state EEG spectral analysis and coherence, 2) working memory as measured by the score on the n-back test and 3) quality of life as measured by the Stroke Aphasia Quality of Life survey tool. The secondary aims will be used to determine the utility of these measures in a larger clinical trial.

-This is a prospective, crossover study, sham-controlled intervention study with two intervention conditions delivered across 6 intervention sessions (3x/week for two weeks) with a 4-week washout in between. Conditions include: 1) sham cerebellar tDCS and 2) real cerebellar tDCS delivered at 2mA across 20 minutes. Each of these will be delivered during CILT intervention with a licensed, certified speech-language pathologist trained in CILT. Once tDCS stimulation has ended, CILT will continue to be delivered for an additional 25 minutes. Assessments of discourse, verbal fluency, working memory and EEG spectral analysis will be conducted at four timepoints, before and after each intervention phase. -
-
-Inclusion Criteria: -
-
  • -over the age of 18 years -
  • -history of stroke -
  • -diagnosed with non-fluent aphasia. -
  • -be able to independently understand simple directions, -
  • -use some speech to communicate, -
  • -have access to reliable transportation (including taxi and/or other transportation services), -
  • -fluent in English.
    -
    • -Exlcusion Criteria: -
    -
  • -Pregnancy, -
  • -history of seizures, -
  • -any metal implants in the body (excluding dental fillings), -
  • -history of migraines, -
  • -psoriasis or eczema affecting the scalp, -
  • -history of a head injury such as a concussion -
  • -diagnosis of a mental health or neurological condition/disease. -
    • -
    -Contact Information: -
    - - - - - - - - - - - - - - - - - - - - - - - - - -
    -Sharyl Samargia-Grivette, PhD -
    -Phone: - -218-726-8347 -
    -Email: - - -
    -Sydney Viel, MPH CPH -
    -Phone: - -612-625-2874 -
    -Email: - - -
    -
    - -
    -


    @@ -6997,7 +6860,7 @@

    Copy these email(s) into your email:

    argye@jhmi.edu, md.stockbridge@jhmi.edu

    Copy this email template into your email:

    -
    +
    Dear Argye Hillis-Trupe and Melissa D Stockbridge,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7010,7 +6873,7 @@

    Copy this email template into your email:

    - +
    @@ -7141,7 +7004,7 @@

    Copy these email(s) into your email:

    sschoenrock@mcw.edu, sapillay@mcw.edu

    Copy this email template into your email:

    -
    +
    Dear Sidney E Schoenrock and Sara Pillay,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7154,7 +7017,7 @@

    Copy this email template into your email:

    - +
    @@ -7275,7 +7138,7 @@

    Copy these email(s) into your email:

    agnes.floeel@uni-greifswald.de, nina.unger@uni-greifswald.de

    Copy this email template into your email:

    -
    +
    Dear Agnes Floeel and Nina Unger,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7288,7 +7151,7 @@

    Copy this email template into your email:

    - +
    @@ -7423,7 +7286,7 @@

    Copy these email(s) into your email:

    lzipse@mghihp.edu

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    -
    +
    Dear Lauryn Zipse,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7436,7 +7299,7 @@

    Copy this email template into your email:

    - +
    @@ -7524,7 +7387,7 @@

    Copy these email(s) into your email:

    ruiqipanedu@163.com

    Copy this email template into your email:

    -
    +
    Dear Ruiqi Pan,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7537,7 +7400,7 @@

    Copy this email template into your email:

    - +
    @@ -7655,7 +7518,7 @@

    Copy these email(s) into your email:

    DRMoser@uams.edu, PSCarr@uams.edu

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    -
    +
    Dear Dana Moser and Portia Carr,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7668,7 +7531,7 @@

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    - +
    @@ -7787,7 +7650,7 @@

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    sdrane@mcw.edu

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    -
    +
    Dear Samantha Drane,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7800,7 +7663,7 @@

    Copy this email template into your email:

    - +
    @@ -7910,7 +7773,7 @@

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    marion.fossard@unine.ch, celia.ericson@unine.ch

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    -
    +
    Dear Marion Fossard and Célia Ericson,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7923,7 +7786,7 @@

    Copy this email template into your email:

    - +
    @@ -8039,7 +7902,7 @@

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    claire.honeycutt@asu.edu

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    -
    +
    Dear Claire F Honeycutt,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8052,7 +7915,7 @@

    Copy this email template into your email:

    - +
    @@ -8144,7 +8007,7 @@

    Copy these email(s) into your email:

    min.wong@polyu.edu.hk, faisal.n.baig@polyu.edu.hk

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    -
    +
    Dear Min Ney WONG and Faisal N Baig,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8157,7 +8020,7 @@

    Copy this email template into your email:

    - +
    @@ -8280,7 +8143,7 @@

    Copy these email(s) into your email:

    charlotta.saldert@neuro.gu.se, francesca.longoni@neuro.gu.se

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    -
    +
    Dear Charlotta Saldert and Francesca Longoni,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8293,7 +8156,7 @@

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    @@ -8406,7 +8269,7 @@

    Copy these email(s) into your email:

    tmontagnon@chu-grenoble.fr

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    -
    +
    Dear University Hospital,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8419,7 +8282,7 @@

    Copy this email template into your email:

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    @@ -8503,7 +8366,7 @@

    Copy these email(s) into your email:

    sschoenrock@mcw.edu

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    -
    +
    Dear Sidney Schoenrock,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8516,7 +8379,7 @@

    Copy this email template into your email:

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    @@ -8604,7 +8467,7 @@

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    amy.rodriguez@va.gov, Laura.Britan_Lang@va.gov

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    -
    +
    Dear Amy D Rodriguez and Laura Britan Lang,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8617,7 +8480,7 @@

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    @@ -8732,7 +8595,7 @@

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    joanne.loewy@mountsinai.org

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    +
    Dear Joanne Loewy,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8745,7 +8608,7 @@

    Copy this email template into your email:

    - +
    @@ -8814,107 +8677,6 @@

    -
    - -


    -
    -
    - -

    Copy these email(s) into your email:

    -

    donosobrowne@duq.edu

    -

    Copy this email template into your email:

    -
    -Dear Elena V Donoso Brown,

    -I found your research on aphasiaresearch.org.
    -I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    -The best way to contact me is:
    -  Caregiver: [Insert your phone / email]
    -  Person with aphasia: [Insert your phone / email]
    -Thank you for doing this research.

    -Sincerely,
    -[Insert your name]

    -
    - -
    - -
    -
    -
    -

    -Home Program Practice for People With Language Disorders After Stroke -

    -
    -Principle Investigator: NA -
    -
    -Institution: Duquesne University -
    -
    -Country: United States -
    -
    -City: Pittsburgh, Pennsylvania -
    -
    -Brief Description: -
    -Logbooks are one of the most commonly used methods to both support and track adherence in research studies. This study will look at using logbooks to support adherence to reading practice for individuals with post-stroke aphasia. It is thought that using a logbook will increase practice time. -
    -
    -Inclusion Criteria: -
    -
  • -at least 6 months post left hemisphere stroke with a diagnosis of aphasia -
  • -must have self-reported interest in working to improve reading comprehension -
  • -access to the Internet -
  • -speak English as a primary language
    -
    • -Exlcusion Criteria: -
    -
  • -significant visual or hearing impairment as determined by “aphasia-friendly” and age-appropriate screening -
  • -actively receiving speech-language pathology services in which computerized or reading comprehension home practice activities are assigned/requested -
  • -severe auditory comprehension impairment that limits understanding of one-step directions (i.e., Western Aphasia Battery-Revised sequential commands subtest score below 8). -
    • -
    -Contact Information: -
    - - - - - - - - - - - - - - -
    -Elena V Donoso Brown, PhD -
    -Phone: - -412-396-5450 -
    -Email: - - -
    -
    - -
    -


    @@ -8924,7 +8686,7 @@

    Copy these email(s) into your email:

    al1579@georgetown.edu, ehl4@georgetown.edu

    Copy this email template into your email:

    -
    +
    Dear Alycia Laks and Elizabeth Lacey,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8937,7 +8699,7 @@

    Copy this email template into your email:

    - +
    @@ -9056,7 +8818,7 @@

    Copy these email(s) into your email:

    argye@jhmi.edu, md.stockbridge@jhmi.edu

    Copy this email template into your email:

    -
    +
    Dear Argye E Hillis and Melissa D Stockbridge,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9069,7 +8831,7 @@

    Copy this email template into your email:

    - +
    @@ -9182,7 +8944,7 @@

    Copy these email(s) into your email:

    Adrian.Guggisberg@insel.ch

    Copy this email template into your email:

    -
    +
    Dear Adrian G Guggisberg,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9195,7 +8957,7 @@

    Copy this email template into your email:

    - +
    @@ -9294,7 +9056,7 @@

    Copy these email(s) into your email:

    amy.rodriguez@va.gov, Laura.Britan_Lang@va.gov

    Copy this email template into your email:

    -
    +
    Dear Amy D Rodriguez and Laura Britan Lang,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9307,7 +9069,7 @@

    Copy this email template into your email:

    - +
    @@ -9418,7 +9180,7 @@

    Copy these email(s) into your email:

    gfz2102@cumc.columbia.edu, eg2972@cumc.columbia.edu

    Copy this email template into your email:

    -
    +
    Dear Galen Ziaggi and Elena M. Golub,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9431,7 +9193,7 @@

    Copy this email template into your email:

    - +
    @@ -9558,7 +9320,7 @@

    Copy these email(s) into your email:

    simona.spaccavento@icsmaugeri.it

    Copy this email template into your email:

    -
    +
    Dear Simona Spaccavento,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9571,7 +9333,7 @@

    Copy this email template into your email:

    - +
    @@ -9669,7 +9431,7 @@

    Copy these email(s) into your email:

    aphasiaresearchlaboratory@gmail.com

    Copy this email template into your email:

    -
    +
    Dear Swathi Kiran,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9682,7 +9444,7 @@

    Copy this email template into your email:

    - +
    @@ -9749,7 +9511,7 @@

    Copy these email(s) into your email:

    bcstark@iu.edu

    Copy this email template into your email:

    -
    +
    Dear Brielle C. Stark,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9762,7 +9524,7 @@

    Copy this email template into your email:

    - +
    @@ -9829,7 +9591,7 @@

    Copy these email(s) into your email:

    bcstark@iu.edu

    Copy this email template into your email:

    -
    +
    Dear Brielle C. Stark,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9842,7 +9604,7 @@

    Copy this email template into your email:

    - +
    @@ -9909,7 +9671,7 @@

    Copy these email(s) into your email:

    tbrancamp@med.unr.edu

    Copy this email template into your email:

    -
    +
    Dear Tami Brancamp,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9922,7 +9684,7 @@

    Copy this email template into your email:

    - +
    @@ -9989,7 +9751,7 @@

    Copy these email(s) into your email:

    rharrington2@gsu.edu

    Copy this email template into your email:

    -
    +
    Dear Rachael Harrington,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -10002,7 +9764,7 @@

    Copy this email template into your email:

    - +
    @@ -10069,7 +9831,7 @@

    Copy these email(s) into your email:

    aphasialab@pdx.edu

    Copy this email template into your email:

    -
    +
    Dear Stacey Steel,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -10082,7 +9844,7 @@

    Copy this email template into your email:

    - +
    diff --git a/docs/recent.html b/docs/recent.html index 002312c..8a8175c 100644 --- a/docs/recent.html +++ b/docs/recent.html @@ -2283,7 +2283,7 @@ - + @@ -2373,8 +2373,8 @@

    Recently added research studies

    -
    - +
    +
    diff --git a/docs/remote.html b/docs/remote.html index 01e6de6..9140740 100644 --- a/docs/remote.html +++ b/docs/remote.html @@ -2283,7 +2283,7 @@ - + @@ -2373,8 +2373,8 @@

    Online research studies

    -
    - +
    +
    diff --git a/docs/site_libs/datatables-binding-0.28/datatables.js b/docs/site_libs/datatables-binding-0.29/datatables.js similarity index 99% rename from docs/site_libs/datatables-binding-0.28/datatables.js rename to docs/site_libs/datatables-binding-0.29/datatables.js index aee8ab5..b930851 100644 --- a/docs/site_libs/datatables-binding-0.28/datatables.js +++ b/docs/site_libs/datatables-binding-0.29/datatables.js @@ -2,7 +2,7 @@ // some helper functions: using a global object DTWidget so that it can be used // in JS() code, e.g. datatable(options = list(foo = JS('code'))); unlike R's -// dynamic scoping, when 'code' is eval()'ed, JavaScript does not know objects +// dynamic scoping, when 'code' is eval'ed, JavaScript does not know objects // from the "parent frame", e.g. JS('DTWidget') will not work unless it was made // a global object var DTWidget = {}; diff --git a/docs/site_libs/jquery-1.12.4/jquery.min.js b/docs/site_libs/jquery-1.12.4/jquery.min.js deleted file mode 100644 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