From 06e8a8dddfde2d275a52d3780150b012c6066e2f Mon Sep 17 00:00:00 2001 From: runner Date: Mon, 13 Nov 2023 00:40:52 +0000 Subject: [PATCH] Re-build website --- data/clinical_trials_clean.csv | 20 ++++++++++---------- data/study_info.rds | Bin 255603 -> 255603 bytes docs/about.html | 2 +- docs/data/clinical_trials_clean.csv | 20 ++++++++++---------- docs/data/study_info.rds | Bin 255603 -> 255603 bytes docs/recent.html | 4 ++-- docs/remote.html | 4 ++-- docs/uk-europe-map.html | 4 ++-- docs/us-canada-map.html | 4 ++-- 9 files changed, 29 insertions(+), 29 deletions(-) diff --git a/data/clinical_trials_clean.csv b/data/clinical_trials_clean.csv index 4eb45b6..44dcea8 100644 --- a/data/clinical_trials_clean.csv +++ b/data/clinical_trials_clean.csv @@ -903,7 +903,7 @@ significant mood disorder. substance/alcohol dependence or abuse within the past year presence of any implanted electrical device or contraindications to tDCS or MRI recent medical instability (within 4 weeks) -pregnancy","No","25 Years","All","Albuquerque","87106","New Mexico","Jessica Richardson","United States",1,"no",-106.6208755,35.083292,2022-10-18 +pregnancy","No","25 Years","All","Albuquerque","87106","New Mexico","Jessica Richardson","United States",1,"no",-106.6196255,35.0863685,2022-10-18 "36",31,"Studying Language With Brain Stimulation in Aphasia","Stroke Aphasia","January 9, 2023","NCT05660304","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The overall goal of this study is to evaluate whether stimulation of two brain areas alongside behavioral speech-language therapy increases connectivity to improve language functions in stroke-aphasia patients.","The brain is made up of networks that communicate with each other to help us think and communicate. After a stroke, networks between different areas of the brain can lose connection. In the case of aphasia, networks in the language areas of the brain are often disrupted. There is currently no ""fix"" to restore these specific language connections. However, transcranial magnetic stimulation (TMS) might help the areas reconnect through alternative pathways. TMS is a non-invasive procedure (in other words, it takes place outside your body). A coil will be placed over your head. The coil sends magnetic pulses to your brain to stimulate, or excite, neurons. Most studies using TMS stimulate one area of the brain at a time, but this does not tell us how to improve the network connections between brain areas. @@ -986,7 +986,7 @@ Exclusion Criteria: History of other acquired or progressive neurological disease. Significant language comprehension impairments (per performance on the CAT - individuals will be excluded if their spoken language comprehension mean modality T- score on the CAT falls below 40). Unmanaged drug / alcohol dependence. -Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.","No","18 Years","All","Pittsburgh","15260","Pennsylvania","William Evans","United States",1,"no",-79.958065,40.44047,2023-09-21 +Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.","No","18 Years","All","Pittsburgh","15260","Pennsylvania","William Evans","United States",1,"no",-79.9543695,40.443979,2023-09-21 "40",36,"Modulating Intensity and Dosage of Aphasia Scripts","Aphasia","September 21, 2020","NCT04138940","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The purpose of this study is to evaluate how changing conditions of speech-language treatment (namely, amount of repetition and distribution of practice schedule) affects the language outcome of participants with aphasia following a stroke. Using a computer based speech and language therapy program, participants will practice conversational scripts that are either short or long. Participants will practice for either 2 weeks (5 days a week) or for 5 weeks (2 days a week).","Determining the optimal intensity of treatment is essential to the design and implementation of any treatment program for aphasia. Yet, treatment intensity is a complex construct and information on the variables modulating it remain ambiguous and limited. Studies reported in the neuroscience and clinical literature support the need for intensive treatment to induce long-term neuroplastic changes while the cognitive psychology literature suggests that learning is best maintained with distributed schedules. A few studies have looked at dose parameters for single word naming tasks, but there is limited evidence regarding dose parameters for treatments that focus on training the production of larger units, such as sentences or even connected discourse. One approach that is frequently used clinically and has evidence for its efficacy is script training. Little is currently known regarding the optimum dose of script training (i.e., the number of repetitions over time of each sentence within the script) that is required to promote the best outcomes. This study investigates the effects of modulating stimulus variables, specifically stimulus practice distribution and stimulus repetition. We use a baseline script treatment that has experimental support regarding its efficacy, and that allows the manipulation of these variables. To ensure independence and fidelity, treatment is provided in a controlled computer environment (desktop and tablet). To avoid clinician-related variables such as expertise and personality factors that may influence treatment, sentences are modeled during treatment by an anthropomorphic agent with high visual speech intelligibility and affective expressions. @@ -1050,7 +1050,7 @@ Exclusion Criteria: History of other acquired or progressive neurological disease. Significant language comprehension impairments (per performance on the CAT - individuals will be excluded if their spoken language comprehension mean modality T- score on the CAT falls below 40). Unmanaged drug / alcohol dependence. -Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.","No","18 Years","All","Pittsburgh","15260","Pennsylvania","William Evans","United States",1,"no",-79.958065,40.44047,2023-09-01 +Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.","No","18 Years","All","Pittsburgh","15260","Pennsylvania","William Evans","United States",1,"no",-79.9543695,40.443979,2023-09-01 "43",39,"Improving Aphasia Using Electrical Brain Stimulation","Stroke Aphasia","July 12, 2021","NCT04963803","Syracuse University Syracuse New York United States","Syracuse University","Recruiting","Language and communication are essential for almost every aspect of human life, but for people who have aphasia, a language processing disorder that can occur after stroke or brain injury, even simple conversations can become a formidable challenge. Speech and language therapy can help people recover their language ability, but often requires months or even years of therapy before a person is able to overcome these challenges. This research will investigate non-invasive brain stimulation as a way to enhance the effects of speech and language therapy, which may ultimately lead to better and faster recovery from stroke and aphasia. The investigators hypothesize that participants with aphasia who receive speech and language therapy paired with active electrical brain stimulation will improve significantly more on a language comprehension task than those who receive speech and language therapy paired with sham stimulation.",NA,"tDCS attention language speech-language therapy","Interventional","Inclusion Criteria: 18 years or older. @@ -2047,7 +2047,7 @@ Exclusion Criteria: Severe apraxia of speech or dysarthria Clinically significant depression For MRI safety: implanted medical devices, metal in the body and claustrophobia.","No","21 Years","All","Decatur","30033-4004","Georgia",NA,"United States",1,"no",-84.296069,33.773758,2021-05-24 -"83",92,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. +"83",91,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. All enrolled participants will be assessed on their mood, past music experience and music genre preference (music therapy assessment). They will complete the abridged Beck (BDI-2-fastscreen) questionnaire, the stoke and aphasia quality of life scale; a Likert which measures distress; the Western Aphasia Battery (WAB); the NIH Stroke Scale (SS); the Figely compassion scale; and the driving scene test (Stern and White); and the Rankin. In additional we will take saliva samples from all participants to measure hormone levels. @@ -2058,7 +2058,7 @@ Stroke victim, regardless of level of stroke Exclusion Criteria: None","No","18 Years","All","New York","10003","New York","Joanne Loewy","United States",1,"no",-73.953275,40.7898205,2014-04-04 -"84",97,"Transcranial Alternating Current Stimulation (tACS) for the Recovery of Phonological Short-Term Memory in Patients With Aphasia After Stroke","Stroke Aphasia","November 2023","NCT06048159","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States. Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits, potentially with brain stimulation concurrent with therapies. +"84",96,"Transcranial Alternating Current Stimulation (tACS) for the Recovery of Phonological Short-Term Memory in Patients With Aphasia After Stroke","Stroke Aphasia","November 2023","NCT06048159","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States. Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits, potentially with brain stimulation concurrent with therapies. The current study will investigate the efficacy of high-definition tACS (HD-tACS) to help restore neural oscillatory activity in stroke survivors with aphasia. TACS differs from trancranial direct current stimulation (tDCS), a widely used brain stimulation paradigm, in that sinusoidal or alternating currents are delivered rather than direct currents. TACS is shown to manipulate ongoing oscillatory brain activity and also to modulate synchronization (or connectivity) between targeted brain areas. This feature of tACS is quite attractive, given the new body of evidence suggesting that language impairments stem from diminished brain connectivity and ensuing disruptions in the language network due to stroke. @@ -2078,7 +2078,7 @@ The presence of cardiac stimulators or pacemakers Contraindications to MRI or tACS, e.g. patients with metallic implants, and/or history of skull fractures, pregnancy, skin diseases History of ongoing or unmanaged seizures History of dyslexia or other developmental learning disabilities","No","18 Years","All","Milwaukee","53226","Wisconsin","Priyanka Shah-Basak, PhD","United States",1,"no",-88.022002,43.04338,2023-11-20 -"85",100,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: +"85",99,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: Stroke Survivors: @@ -2103,7 +2103,7 @@ Additional Exclusion Criteria for MRIs: Pacemaker or magnetic metal in the body that is not MRI compatible Pregnancy Claustrophobia","Accepts Healthy Volunteers","18 Years","All","Washington","20057","District of Columbia",NA,"United States",1,"no",-77.078807,38.911961,2018-11-01 -"86",102,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: +"86",101,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: Diagnosis of aphasia secondary to stroke and presence of naming deficits (at least 20% errors on the Boston Naming Test or Hopkins Action Naming Assessment) Capable of giving informed consent or indicating another to provide informed consent @@ -2117,7 +2117,7 @@ Lack of English proficiency (by self/legally authorized representative report) Prior history of neurologic disease affecting the brain (e.g., brain tumor, multiple sclerosis, traumatic brain injury) other than stroke Prior history of severe psychiatric illness, developmental disorders or intellectual disability (e.g., PTSD, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders) Uncorrected severe visual loss or hearing loss by self-report and medical records","No","18 Years","All","Baltimore","21287","Maryland",NA,"United States",1,"no",-76.6204945,39.3289375,2023-05-31 -"87",104,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. +"87",103,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. However, language processes are not determined solely by local neural activity at a single site, but rather by the interaction between neural networks. This is because a large cortical network is involved in language processes and, therefore, the same language disorder may result from lesions at different locations in this network. @@ -2143,7 +2143,7 @@ Impaired alertness or delirium Severe co-morbidity affecting speech Contraindication to tDCS: pregnant women, patients with active implants such as pacemakers or cochlear implants, patients with one or more seizures, metal objects in the brain Occurrence of a new stroke during the study protocol.","No","18 Years","All","Geneva","1211","GE","Adrian Guggisberg","Switzerland",1,"no",6.1486155,46.1937405,2022-10-24 -"88",114,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: +"88",113,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: Posterior cortical atrophy - a version of Alzheimer's disease with vision difficulties Logopenic variant primary progressive aphasia - a version of Alzheimer's disease with language difficulties @@ -2177,7 +2177,7 @@ Conditions precluding entry into the scanners (e.g. morbid obesity, claustrophob Exposure to research related radiation in the past year that, when combined with this study, would place subjects above the allowable limits. Participation in the last year in a clinical trial for a disease modifying drug for AD. Taking immunosuppressive medication (e.g., glucocorticoids, cytostatics, antibodies, drugs acting on immunophilins, interferons, tumor necrosis factor inhibitors). Nonsteroidal anti-inflammatory drugs (NSAIDs) are not exclusionary.","Accepts Healthy Volunteers","50 Years","All","New York","10032","New York","James M Noble, MD, MS, CPH, FAAN","United States",1,"no",-73.9622875,40.807223,2020-11-17 -"89",167,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: +"89",165,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: to evaluate the residual neuroplastic processes in DOC state related to music exposure to determine the putative modulation of the aforementioned processes and the clinical outcome of DOC patients by non-pharmacological strategies, i.e., electric (tDCS) and music stimulation diff --git a/data/study_info.rds b/data/study_info.rds index 2b88712d0e3a622f566c626776625a0e5918c7f6..5f021865489aa06c52a23bae2c54d8903517829a 100644 GIT binary patch delta 51 xcmex-hX3;!{s|u?qZt?&5`Z`vh*N<$9f%8ocxf{iV>=fk2s3TxVr0&I3IJL1Bi=&czH7yV>=fk2s3TxVr0&I3IJ>_3About this Website

This website was built primarily using data from the clinicaltrials.gov API to identify studies that included a keyword or condition listing of Aphasia (excluding primary progressive aphasia and other dementias.)

-

It was last updated on November 06 2023

+

It was last updated on November 13 2023

To add your study to this website, submit the study to clinicaltrials.gov. This has a number of benefits for the research community and general public. While submission to clinicaltrials.gov is required for funded clinical trials in the US, voluntary submission is also permitted for other studies.

If submitting your study to clinicaltrials.gov is not feasible or is overly burdensome, you can add an IRB-approved flyer to the website by submitting an issue on github.com. Note that you will will need to create a github account. This is free and helps me keep track of submissions.

If you notice an error on the website, please contact me or file an issue here.

diff --git a/docs/data/clinical_trials_clean.csv b/docs/data/clinical_trials_clean.csv index 4eb45b6..44dcea8 100644 --- a/docs/data/clinical_trials_clean.csv +++ b/docs/data/clinical_trials_clean.csv @@ -903,7 +903,7 @@ significant mood disorder. substance/alcohol dependence or abuse within the past year presence of any implanted electrical device or contraindications to tDCS or MRI recent medical instability (within 4 weeks) -pregnancy","No","25 Years","All","Albuquerque","87106","New Mexico","Jessica Richardson","United States",1,"no",-106.6208755,35.083292,2022-10-18 +pregnancy","No","25 Years","All","Albuquerque","87106","New Mexico","Jessica Richardson","United States",1,"no",-106.6196255,35.0863685,2022-10-18 "36",31,"Studying Language With Brain Stimulation in Aphasia","Stroke Aphasia","January 9, 2023","NCT05660304","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The overall goal of this study is to evaluate whether stimulation of two brain areas alongside behavioral speech-language therapy increases connectivity to improve language functions in stroke-aphasia patients.","The brain is made up of networks that communicate with each other to help us think and communicate. After a stroke, networks between different areas of the brain can lose connection. In the case of aphasia, networks in the language areas of the brain are often disrupted. There is currently no ""fix"" to restore these specific language connections. However, transcranial magnetic stimulation (TMS) might help the areas reconnect through alternative pathways. TMS is a non-invasive procedure (in other words, it takes place outside your body). A coil will be placed over your head. The coil sends magnetic pulses to your brain to stimulate, or excite, neurons. Most studies using TMS stimulate one area of the brain at a time, but this does not tell us how to improve the network connections between brain areas. @@ -986,7 +986,7 @@ Exclusion Criteria: History of other acquired or progressive neurological disease. Significant language comprehension impairments (per performance on the CAT - individuals will be excluded if their spoken language comprehension mean modality T- score on the CAT falls below 40). Unmanaged drug / alcohol dependence. -Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.","No","18 Years","All","Pittsburgh","15260","Pennsylvania","William Evans","United States",1,"no",-79.958065,40.44047,2023-09-21 +Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.","No","18 Years","All","Pittsburgh","15260","Pennsylvania","William Evans","United States",1,"no",-79.9543695,40.443979,2023-09-21 "40",36,"Modulating Intensity and Dosage of Aphasia Scripts","Aphasia","September 21, 2020","NCT04138940","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The purpose of this study is to evaluate how changing conditions of speech-language treatment (namely, amount of repetition and distribution of practice schedule) affects the language outcome of participants with aphasia following a stroke. Using a computer based speech and language therapy program, participants will practice conversational scripts that are either short or long. Participants will practice for either 2 weeks (5 days a week) or for 5 weeks (2 days a week).","Determining the optimal intensity of treatment is essential to the design and implementation of any treatment program for aphasia. Yet, treatment intensity is a complex construct and information on the variables modulating it remain ambiguous and limited. Studies reported in the neuroscience and clinical literature support the need for intensive treatment to induce long-term neuroplastic changes while the cognitive psychology literature suggests that learning is best maintained with distributed schedules. A few studies have looked at dose parameters for single word naming tasks, but there is limited evidence regarding dose parameters for treatments that focus on training the production of larger units, such as sentences or even connected discourse. One approach that is frequently used clinically and has evidence for its efficacy is script training. Little is currently known regarding the optimum dose of script training (i.e., the number of repetitions over time of each sentence within the script) that is required to promote the best outcomes. This study investigates the effects of modulating stimulus variables, specifically stimulus practice distribution and stimulus repetition. We use a baseline script treatment that has experimental support regarding its efficacy, and that allows the manipulation of these variables. To ensure independence and fidelity, treatment is provided in a controlled computer environment (desktop and tablet). To avoid clinician-related variables such as expertise and personality factors that may influence treatment, sentences are modeled during treatment by an anthropomorphic agent with high visual speech intelligibility and affective expressions. @@ -1050,7 +1050,7 @@ Exclusion Criteria: History of other acquired or progressive neurological disease. Significant language comprehension impairments (per performance on the CAT - individuals will be excluded if their spoken language comprehension mean modality T- score on the CAT falls below 40). Unmanaged drug / alcohol dependence. -Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.","No","18 Years","All","Pittsburgh","15260","Pennsylvania","William Evans","United States",1,"no",-79.958065,40.44047,2023-09-01 +Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.","No","18 Years","All","Pittsburgh","15260","Pennsylvania","William Evans","United States",1,"no",-79.9543695,40.443979,2023-09-01 "43",39,"Improving Aphasia Using Electrical Brain Stimulation","Stroke Aphasia","July 12, 2021","NCT04963803","Syracuse University Syracuse New York United States","Syracuse University","Recruiting","Language and communication are essential for almost every aspect of human life, but for people who have aphasia, a language processing disorder that can occur after stroke or brain injury, even simple conversations can become a formidable challenge. Speech and language therapy can help people recover their language ability, but often requires months or even years of therapy before a person is able to overcome these challenges. This research will investigate non-invasive brain stimulation as a way to enhance the effects of speech and language therapy, which may ultimately lead to better and faster recovery from stroke and aphasia. The investigators hypothesize that participants with aphasia who receive speech and language therapy paired with active electrical brain stimulation will improve significantly more on a language comprehension task than those who receive speech and language therapy paired with sham stimulation.",NA,"tDCS attention language speech-language therapy","Interventional","Inclusion Criteria: 18 years or older. @@ -2047,7 +2047,7 @@ Exclusion Criteria: Severe apraxia of speech or dysarthria Clinically significant depression For MRI safety: implanted medical devices, metal in the body and claustrophobia.","No","21 Years","All","Decatur","30033-4004","Georgia",NA,"United States",1,"no",-84.296069,33.773758,2021-05-24 -"83",92,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. +"83",91,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. All enrolled participants will be assessed on their mood, past music experience and music genre preference (music therapy assessment). They will complete the abridged Beck (BDI-2-fastscreen) questionnaire, the stoke and aphasia quality of life scale; a Likert which measures distress; the Western Aphasia Battery (WAB); the NIH Stroke Scale (SS); the Figely compassion scale; and the driving scene test (Stern and White); and the Rankin. In additional we will take saliva samples from all participants to measure hormone levels. @@ -2058,7 +2058,7 @@ Stroke victim, regardless of level of stroke Exclusion Criteria: None","No","18 Years","All","New York","10003","New York","Joanne Loewy","United States",1,"no",-73.953275,40.7898205,2014-04-04 -"84",97,"Transcranial Alternating Current Stimulation (tACS) for the Recovery of Phonological Short-Term Memory in Patients With Aphasia After Stroke","Stroke Aphasia","November 2023","NCT06048159","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States. Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits, potentially with brain stimulation concurrent with therapies. +"84",96,"Transcranial Alternating Current Stimulation (tACS) for the Recovery of Phonological Short-Term Memory in Patients With Aphasia After Stroke","Stroke Aphasia","November 2023","NCT06048159","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States. Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits, potentially with brain stimulation concurrent with therapies. The current study will investigate the efficacy of high-definition tACS (HD-tACS) to help restore neural oscillatory activity in stroke survivors with aphasia. TACS differs from trancranial direct current stimulation (tDCS), a widely used brain stimulation paradigm, in that sinusoidal or alternating currents are delivered rather than direct currents. TACS is shown to manipulate ongoing oscillatory brain activity and also to modulate synchronization (or connectivity) between targeted brain areas. This feature of tACS is quite attractive, given the new body of evidence suggesting that language impairments stem from diminished brain connectivity and ensuing disruptions in the language network due to stroke. @@ -2078,7 +2078,7 @@ The presence of cardiac stimulators or pacemakers Contraindications to MRI or tACS, e.g. patients with metallic implants, and/or history of skull fractures, pregnancy, skin diseases History of ongoing or unmanaged seizures History of dyslexia or other developmental learning disabilities","No","18 Years","All","Milwaukee","53226","Wisconsin","Priyanka Shah-Basak, PhD","United States",1,"no",-88.022002,43.04338,2023-11-20 -"85",100,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: +"85",99,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: Stroke Survivors: @@ -2103,7 +2103,7 @@ Additional Exclusion Criteria for MRIs: Pacemaker or magnetic metal in the body that is not MRI compatible Pregnancy Claustrophobia","Accepts Healthy Volunteers","18 Years","All","Washington","20057","District of Columbia",NA,"United States",1,"no",-77.078807,38.911961,2018-11-01 -"86",102,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: +"86",101,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: Diagnosis of aphasia secondary to stroke and presence of naming deficits (at least 20% errors on the Boston Naming Test or Hopkins Action Naming Assessment) Capable of giving informed consent or indicating another to provide informed consent @@ -2117,7 +2117,7 @@ Lack of English proficiency (by self/legally authorized representative report) Prior history of neurologic disease affecting the brain (e.g., brain tumor, multiple sclerosis, traumatic brain injury) other than stroke Prior history of severe psychiatric illness, developmental disorders or intellectual disability (e.g., PTSD, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders) Uncorrected severe visual loss or hearing loss by self-report and medical records","No","18 Years","All","Baltimore","21287","Maryland",NA,"United States",1,"no",-76.6204945,39.3289375,2023-05-31 -"87",104,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. +"87",103,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. However, language processes are not determined solely by local neural activity at a single site, but rather by the interaction between neural networks. This is because a large cortical network is involved in language processes and, therefore, the same language disorder may result from lesions at different locations in this network. @@ -2143,7 +2143,7 @@ Impaired alertness or delirium Severe co-morbidity affecting speech Contraindication to tDCS: pregnant women, patients with active implants such as pacemakers or cochlear implants, patients with one or more seizures, metal objects in the brain Occurrence of a new stroke during the study protocol.","No","18 Years","All","Geneva","1211","GE","Adrian Guggisberg","Switzerland",1,"no",6.1486155,46.1937405,2022-10-24 -"88",114,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: +"88",113,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: Posterior cortical atrophy - a version of Alzheimer's disease with vision difficulties Logopenic variant primary progressive aphasia - a version of Alzheimer's disease with language difficulties @@ -2177,7 +2177,7 @@ Conditions precluding entry into the scanners (e.g. morbid obesity, claustrophob Exposure to research related radiation in the past year that, when combined with this study, would place subjects above the allowable limits. Participation in the last year in a clinical trial for a disease modifying drug for AD. Taking immunosuppressive medication (e.g., glucocorticoids, cytostatics, antibodies, drugs acting on immunophilins, interferons, tumor necrosis factor inhibitors). Nonsteroidal anti-inflammatory drugs (NSAIDs) are not exclusionary.","Accepts Healthy Volunteers","50 Years","All","New York","10032","New York","James M Noble, MD, MS, CPH, FAAN","United States",1,"no",-73.9622875,40.807223,2020-11-17 -"89",167,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: +"89",165,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: to evaluate the residual neuroplastic processes in DOC state related to music exposure to determine the putative modulation of the aforementioned processes and the clinical outcome of DOC patients by non-pharmacological strategies, i.e., electric (tDCS) and music stimulation diff --git a/docs/data/study_info.rds b/docs/data/study_info.rds index 2b88712d0e3a622f566c626776625a0e5918c7f6..5f021865489aa06c52a23bae2c54d8903517829a 100644 GIT binary patch delta 51 xcmex-hX3;!{s|u?qZt?&5`Z`vh*N<$9f%8ocxf{iV>=fk2s3TxVr0&I3IJL1Bi=&czH7yV>=fk2s3TxVr0&I3IJ>_3Recently added research studies
-
- +
+
diff --git a/docs/remote.html b/docs/remote.html index 820d057..7e56fd3 100644 --- a/docs/remote.html +++ b/docs/remote.html @@ -2399,8 +2399,8 @@

Online research studies

-
- +
+
diff --git a/docs/uk-europe-map.html b/docs/uk-europe-map.html index 1e2439c..2570939 100644 --- a/docs/uk-europe-map.html +++ b/docs/uk-europe-map.html @@ -2413,8 +2413,8 @@

Current Aphasia Research Studies

-
- +
+
diff --git a/docs/us-canada-map.html b/docs/us-canada-map.html index 885ef6c..4b08db5 100644 --- a/docs/us-canada-map.html +++ b/docs/us-canada-map.html @@ -2413,8 +2413,8 @@

Current Aphasia Research Studies

-
- +
+