From 36d7c844161d77b2dd1a2f32b03746426dc6ad00 Mon Sep 17 00:00:00 2001 From: runner Date: Mon, 21 Aug 2023 00:39:03 +0000 Subject: [PATCH] Re-build website --- data/clinical_trials_clean.csv | 177 ++++----- data/contact.rds | Bin 10843 -> 10656 bytes data/data_dt.rds | Bin 17060 -> 16913 bytes data/location.rds | Bin 5171 -> 5094 bytes data/study_info.rds | Bin 244673 -> 241536 bytes docs/LICENSE.html | 6 +- docs/about.html | 8 +- docs/data/clinical_trials_clean.csv | 177 ++++----- docs/data/contact.rds | Bin 10843 -> 10656 bytes docs/data/data_dt.rds | Bin 17060 -> 16913 bytes docs/data/location.rds | Bin 5171 -> 5094 bytes docs/data/study_info.rds | Bin 244673 -> 241536 bytes docs/index.html | 6 +- docs/list_view.html | 366 ++++++------------ docs/recent.html | 10 +- docs/remote.html | 10 +- .../webfonts/fa-brands-400.woff2 | Bin 108020 -> 0 bytes .../webfonts/fa-regular-400.woff2 | Bin 24948 -> 0 bytes .../webfonts/fa-solid-900.woff2 | Bin 150124 -> 0 bytes .../webfonts/fa-v4compatibility.woff2 | Bin 4564 -> 0 bytes .../css/all.css | 17 +- .../css/all.min.css | 4 +- .../css/v4-shims.css | 2 +- .../css/v4-shims.min.css | 2 +- .../webfonts/fa-brands-400.ttf | Bin 187208 -> 189684 bytes .../webfonts/fa-brands-400.woff2 | Bin 0 -> 109808 bytes .../webfonts/fa-regular-400.ttf | Bin 63952 -> 63348 bytes .../webfonts/fa-regular-400.woff2 | Bin 0 -> 24488 bytes .../webfonts/fa-solid-900.ttf | Bin 394628 -> 394668 bytes .../webfonts/fa-solid-900.woff2 | Bin 0 -> 150020 bytes .../webfonts/fa-v4compatibility.ttf | Bin 10172 -> 10172 bytes .../webfonts/fa-v4compatibility.woff2 | Bin 0 -> 4568 bytes .../header-attrs.js | 0 docs/uk-europe-map.html | 10 +- docs/us-canada-map.html | 10 +- 35 files changed, 331 insertions(+), 474 deletions(-) delete mode 100644 docs/site_libs/font-awesome-6.4.0/webfonts/fa-brands-400.woff2 delete mode 100644 docs/site_libs/font-awesome-6.4.0/webfonts/fa-regular-400.woff2 delete mode 100644 docs/site_libs/font-awesome-6.4.0/webfonts/fa-solid-900.woff2 delete mode 100644 docs/site_libs/font-awesome-6.4.0/webfonts/fa-v4compatibility.woff2 rename docs/site_libs/{font-awesome-6.4.0 => font-awesome-6.4.2}/css/all.css (99%) rename docs/site_libs/{font-awesome-6.4.0 => font-awesome-6.4.2}/css/all.min.css (85%) rename docs/site_libs/{font-awesome-6.4.0 => font-awesome-6.4.2}/css/v4-shims.css (99%) rename docs/site_libs/{font-awesome-6.4.0 => font-awesome-6.4.2}/css/v4-shims.min.css (99%) rename docs/site_libs/{font-awesome-6.4.0 => font-awesome-6.4.2}/webfonts/fa-brands-400.ttf (92%) create mode 100644 docs/site_libs/font-awesome-6.4.2/webfonts/fa-brands-400.woff2 rename docs/site_libs/{font-awesome-6.4.0 => font-awesome-6.4.2}/webfonts/fa-regular-400.ttf (90%) create mode 100644 docs/site_libs/font-awesome-6.4.2/webfonts/fa-regular-400.woff2 rename docs/site_libs/{font-awesome-6.4.0 => font-awesome-6.4.2}/webfonts/fa-solid-900.ttf (97%) create mode 100644 docs/site_libs/font-awesome-6.4.2/webfonts/fa-solid-900.woff2 rename docs/site_libs/{font-awesome-6.4.0 => font-awesome-6.4.2}/webfonts/fa-v4compatibility.ttf (86%) create mode 100644 docs/site_libs/font-awesome-6.4.2/webfonts/fa-v4compatibility.woff2 rename docs/site_libs/{header-attrs-2.23 => header-attrs-2.24}/header-attrs.js (100%) diff --git a/data/clinical_trials_clean.csv b/data/clinical_trials_clean.csv index e47ac2f..b80b8ca 100644 --- a/data/clinical_trials_clean.csv +++ b/data/clinical_trials_clean.csv @@ -234,26 +234,7 @@ passed an audiometric pure-tone, air conduction screening at 25 dB HL at 1K, 2K Exclusion Criteria: English as a second language Right hemisphere stroke Less than 6 months post-onset of stroke.",NA,"21 Years","All","Seattle","98105","Washington","Nadine Martin","United States",1,"no",-122.290177,47.538942,2017-12-15 -"10",7,"Impact of Group Participation on Adults With Aphasia","Aphasia, Acquired Stroke Rehabilitation Language Disorder, Acquired","September 6, 2022","NCT05520528","University of Arkansas Little Rock Arkansas United States","University of Arkansas","Recruiting","The purpose of the study is to examine the impact of group participation on adults with aphasia. Participants will complete a standard pre-and post-assessment of language abilities (speech, comprehension, reading, and/or writing). Then participants will attend 90-minute weekly reading group sessions during an academic semester.","The objective of this research is to determine if attendance in groups positively impacts language skills, activity/participation, and/or quality of life in persons with aphasia. - -This study will employ a university-clinic based outpatient group to administer language intervention. The specific aims of this study are to determine if group participation improves (1) life participation as measured by self-report questionnaires, (2) intervention-specific language skills as measured by treatment-related measures (e.g., reading comprehension and written expression), and (3) performance on non-treated language test scores as measured by a language assessment battery. - -Participants will complete 4-5 individual testing sessions (e.g., initial assessment and pre-/post-testing), 7-12 group sessions (90-minute weekly reading group session), and 7-12 independent sessions at home (e.g., completion of weekly reading assignments). - -The participants will read through a designated book incrementally across multiple weeks. The activities completed during the group sessions will focus on improving reading comprehension and written expression skills. Participants will read assigned passages at home and during the group sessions. Participants will complete a Copy and Recall Treatment (CART) worksheet independently to facilitate improvements in writing keywords related to the reading materials. CART involves copying target words and progresses to writing words from recall (Beeson, et al.). Participants will complete a reading comprehension worksheet and engage in discussion regarding the assigned book chapter. - -Reading comprehension and written expression data will be collected and analyzed to compare the pre-treatment baseline performance from the first treatment session to the post-treatment performance from the last treatment session. Pre-and post-testing scores will be analyzed to investigate the change in scores across the 2-time points to determine the relative effectiveness of book club participation for improving reading comprehension, written expression, and life participation.","","Interventional","Inclusion Criteria: - -Age 18 years or older -Pre-morbid proficient speaker of English -Diagnosis of adult-onset aphasia -Vision and hearing sufficient to complete assessments - -Exclusion Criteria: - -No history of childhood speech or language difficulties -No history of major psychiatric illness, cognitive impairment, or neurological disorders such as seizures","No","18 Years","All","Little Rock","72204","Arkansas",NA,"United States",1,"no",-92.3396525,34.7224165,2022-09-06 -"11",8,"Incorporating Strategy Training Into Naming Treatment in Aphasia","Aphasia","August 30, 2021","NCT05307796","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","This study incorporates metacognitive strategy training into semantic feature analysis treatment. Semantic feature analysis treatment has a strong evidence base and capacity to improve word retrieval by encouraging circumlocution. Circumlocution facilitates self-cued naming and assists listener comprehension when naming fails. However, semantic feature analysis treatment does not include direct techniques to teach patients with aphasia to generalize the use of semantic feature analysis treatment's circumlocution procedure. Therefore, this study proposes that combining semantic feature analysis treatment and metacognitive strategy training will stimulate the semantic system and increase patients with aphasias' use of circumlocution across divergent contexts. +"10",7,"Incorporating Strategy Training Into Naming Treatment in Aphasia","Aphasia","August 30, 2021","NCT05307796","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","This study incorporates metacognitive strategy training into semantic feature analysis treatment. Semantic feature analysis treatment has a strong evidence base and capacity to improve word retrieval by encouraging circumlocution. Circumlocution facilitates self-cued naming and assists listener comprehension when naming fails. However, semantic feature analysis treatment does not include direct techniques to teach patients with aphasia to generalize the use of semantic feature analysis treatment's circumlocution procedure. Therefore, this study proposes that combining semantic feature analysis treatment and metacognitive strategy training will stimulate the semantic system and increase patients with aphasias' use of circumlocution across divergent contexts. This study aims to measure the treatment's effect on naming accuracy for trained and untrained items. The study also aim to measure the treatment's effect on people with aphasias' knowledge of the strategy components and changes in verbalizations during retrieval attempts. The central hypothesis is that strategy training will increase patients with aphasias' explicit knowledge about circumlocution and enable them to use it to (1) self-facilitate naming, and (2) produce more informative connected speech.","Every 40 seconds, someone in the United States suffers from a stroke. Approximately 25% of stroke survivors acquire aphasia, a communication disorder that can result in a partial or total loss of spoken and written language ability, which significantly and negatively impacts quality of life and societal participation. The ability to verbally label objects, referred to as 'naming' in the literature, is impaired in all patients with aphasia. Naming is, therefore, a common focus of treatment. Naming treatments improve people with aphasias' naming ability for items that are directly trained during therapy. However, these same treatments face two critical limitations: (1) inconsistent generalization to untrained items, and (2) little to no generalization to spontaneous, connected speech. As it is impossible to train the entire universe of objects during a patient's course of therapy, generalization of gains beyond what is trained in therapy is crucial. @@ -275,7 +256,7 @@ Exclusion criteria: Experienced multiple strokes; Be in the acute stage of their aphasia, <6 months post onset of stroke; Have a diagnosis of neurodegenerative disease, significant mental illness, psychiatric disorder, drug/alcohol abuse, or neurological condition that could influence cognitive, language, and memory systems","No","18 Years","All","Boston","02129","Massachusetts","Sofia Vallila Rohter","United States",1,"no",-71.0537615,42.3756115,2021-08-30 -"12",9,"Speech Entrainment for Aphasia Recovery","Aphasia Aphasia Non Fluent Stroke","August 21, 2020","NCT04364854","Medical University of South Carolina Charleston South Carolina United States","Medical University of South Carolina","Recruiting","After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production. +"11",8,"Speech Entrainment for Aphasia Recovery","Aphasia Aphasia Non Fluent Stroke","August 21, 2020","NCT04364854","Medical University of South Carolina Charleston South Carolina United States","Medical University of South Carolina","Recruiting","After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production. Participants who are eligible will undergo baseline language testing, an MRI, and will be randomized into one of 4 treatment groups: SET for 3 weeks, SET for 4.5 weeks, SET for 6 weeks, and no treatment (control group).",NA,"Aphasia Speech Language Pathology Therapy","Interventional","Inclusion Criteria @@ -299,7 +280,7 @@ Uncorrectable hearing as determined by the SLP's clinical judgment. Uncorrectable vision. Contraindications to MRI or inability to complete the MRI scanning session. Women who are pregnant.","No","21 Years","All","Charleston","29401","South Carolina","Leonardo Bonilha","United States",1,"no",-79.947297,32.784808,2020-08-21 -"13",9,"Speech Entrainment for Aphasia Recovery","Aphasia Aphasia Non Fluent Stroke","August 21, 2020","NCT04364854","Medical University of South Carolina Columbia South Carolina United States","Medical University of South Carolina","Recruiting","After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production. +"12",8,"Speech Entrainment for Aphasia Recovery","Aphasia Aphasia Non Fluent Stroke","August 21, 2020","NCT04364854","Medical University of South Carolina Columbia South Carolina United States","Medical University of South Carolina","Recruiting","After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production. Participants who are eligible will undergo baseline language testing, an MRI, and will be randomized into one of 4 treatment groups: SET for 3 weeks, SET for 4.5 weeks, SET for 6 weeks, and no treatment (control group).",NA,"Aphasia Speech Language Pathology Therapy","Interventional","Inclusion Criteria @@ -323,7 +304,7 @@ Uncorrectable hearing as determined by the SLP's clinical judgment. Uncorrectable vision. Contraindications to MRI or inability to complete the MRI scanning session. Women who are pregnant.","No","21 Years","All","Columbia","29208","South Carolina","Leonardo Bonilha","United States",1,"no",-81.026403,33.997832,2020-08-21 -"14",9,"Speech Entrainment for Aphasia Recovery","Aphasia Aphasia Non Fluent Stroke","August 21, 2020","NCT04364854","Medical University of South Carolina Salt Lake City Utah United States","Medical University of South Carolina","Recruiting","After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production. +"13",8,"Speech Entrainment for Aphasia Recovery","Aphasia Aphasia Non Fluent Stroke","August 21, 2020","NCT04364854","Medical University of South Carolina Salt Lake City Utah United States","Medical University of South Carolina","Recruiting","After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production. Participants who are eligible will undergo baseline language testing, an MRI, and will be randomized into one of 4 treatment groups: SET for 3 weeks, SET for 4.5 weeks, SET for 6 weeks, and no treatment (control group).",NA,"Aphasia Speech Language Pathology Therapy","Interventional","Inclusion Criteria @@ -347,7 +328,7 @@ Uncorrectable hearing as determined by the SLP's clinical judgment. Uncorrectable vision. Contraindications to MRI or inability to complete the MRI scanning session. Women who are pregnant.","No","21 Years","All","Salt Lake City","84112","Utah","Leonardo Bonilha","United States",1,"no",-111.915493,40.77689,2020-08-21 -"15",10,"DUbbing Language-therapy CINEma-based in Aphasia Post-Stroke","Aphasia, Post-Ictal","December 18, 2020","NCT04289493","Instituto de Investigación Hospital Universitario La Paz Madrid NA Spain","Instituto de Investigación Hospital Universitario La Paz","Recruiting","The DULCINEA study aims to develop and validate a new therapy that integrates essential language characteristics and functional communication by dubbing scenes from television series that represent daily situations. It will be a randomized, crossed over, interventional pilot study recruiting 54 patients with poststroke nonfluent aphasia. Patients will be treated individually in 40-minute sessions twice a week for 8 weeks. In each session, a speech therapist and an actor will select the clips with muted words or sentences that have been detected as functionally meaningful for each patient. Outcomes will be assessed as significant differences in two aphasia tests.","The DULCINEA study aims to develop and validate a new therapy that integrates essential language characteristics and functional communication by dubbing scenes from TV series that represent daily situations. It will be a randomized, crossed over, interventional pilot study recruiting 54 patients with poststroke nonfluent aphasia from the departments of Neurology and Rehabilitation from La Paz University Hospital and also from the ""Afasia Activa"" association. After meeting all inclusion and none of the exclusion criteria and signing informed consent, patients will be randomised (1:1) in two different treatment groups. The first group will receive therapy within the first 3 months of their inclusion with a subsequent period of another 3 months without therapy (thus, serving as group 2 controls). Group 2 will initiate therapy after 3 months since their inclusion (serving as group 1 controls during the first 3 months). Therapy consists of 17 sessions performed in a eight week period (1 baseline session and 16 dubbing sessions), each lasting 40 minutes, in which the patient will be asked to dubb words or sentences previously selected and considered as functionally meaningful for them. These words will be chosen through an online survey performed by a representative group of aphasic patients and the study patients´own relatives in the baseline treatment session. Outcomes will be assessed as significant differences in two aphasia tests (CAL questionnaire and the BDAE).","Rehabilitation Word dubbing Functional communication","Interventional","Inclusion Criteria: +"14",9,"DUbbing Language-therapy CINEma-based in Aphasia Post-Stroke","Aphasia, Post-Ictal","December 18, 2020","NCT04289493","Instituto de Investigación Hospital Universitario La Paz Madrid NA Spain","Instituto de Investigación Hospital Universitario La Paz","Recruiting","The DULCINEA study aims to develop and validate a new therapy that integrates essential language characteristics and functional communication by dubbing scenes from television series that represent daily situations. It will be a randomized, crossed over, interventional pilot study recruiting 54 patients with poststroke nonfluent aphasia. Patients will be treated individually in 40-minute sessions twice a week for 8 weeks. In each session, a speech therapist and an actor will select the clips with muted words or sentences that have been detected as functionally meaningful for each patient. Outcomes will be assessed as significant differences in two aphasia tests.","The DULCINEA study aims to develop and validate a new therapy that integrates essential language characteristics and functional communication by dubbing scenes from TV series that represent daily situations. It will be a randomized, crossed over, interventional pilot study recruiting 54 patients with poststroke nonfluent aphasia from the departments of Neurology and Rehabilitation from La Paz University Hospital and also from the ""Afasia Activa"" association. After meeting all inclusion and none of the exclusion criteria and signing informed consent, patients will be randomised (1:1) in two different treatment groups. The first group will receive therapy within the first 3 months of their inclusion with a subsequent period of another 3 months without therapy (thus, serving as group 2 controls). Group 2 will initiate therapy after 3 months since their inclusion (serving as group 1 controls during the first 3 months). Therapy consists of 17 sessions performed in a eight week period (1 baseline session and 16 dubbing sessions), each lasting 40 minutes, in which the patient will be asked to dubb words or sentences previously selected and considered as functionally meaningful for them. These words will be chosen through an online survey performed by a representative group of aphasic patients and the study patients´own relatives in the baseline treatment session. Outcomes will be assessed as significant differences in two aphasia tests (CAL questionnaire and the BDAE).","Rehabilitation Word dubbing Functional communication","Interventional","Inclusion Criteria: nonfluent aphasia due to unilateral stroke in the left hemisphere without neuroimaging evidence of lesions in the right hemisphere. the patient should have received a standard program of conventional speech therapy after stroke, remaining with aphasia with the following characteristics: severely restricted language, poor repetition (even for single words), not exceeding the 70th percentile in the Boston Diagnostic Aphasia Examination (BDAE) for repetition. Moderately preserved language comprehension: listening comprehension exceeding the 15th percentile of BDAE (average score obtained in three areas: word comprehension, commands and complex ideational material). @@ -357,7 +338,7 @@ Exclusion Criteria: Any clinical condition (short life expectancy, coexisting disease) or other characteristics that precluded appropriate follow-up. Participation in any therapeutic trial evaluating poststroke recovery.","No",NA,"All","Madrid","28046",NA,NA,"Spain",1,"no",-3.6871885,40.4807815,2020-12-18 -"16",12,"Establishment of Virtual Reality System for Stroke Patients With Aphasia","Aphasia","April 7, 2022","NCT05606393","Taipei Veterans General Hospital, Taiwan Taipei city NA Taiwan","Taipei Veterans General Hospital, Taiwan","Recruiting","Aphasia can significantly influence a person's social relationship and quality of life. To achieve positive language outcomes, an intensive and high-repetition speech therapy is essential. However, due to the limited number of speech therapists, the intensity and frequency of training are often insufficient. Therefore, it is critical to develop other rehabilitation approaches to enhance the benefits of aphasia intervention. Virtual reality (VR) is an immersive and interactive computer simulation technology that can promote the ecological validity of speech therapy. In this study, we develop an innovative VR software for speech training to explore the effects of VR on various aspects of language outcomes.","We randomly assigned study participants into 2 groups: the traditional speech therapy (ST) group and the traditional ST with additional VR training (ST+VR) group. In the ST group, each participant received 1-hour traditional ST for each session. In the ST+VR group, an additional 30-minute VR training was administered immediately after each session of traditional ST. All participants received 3 sessions of treatment every week for 3 weeks. For outcome measurement, we administered Concise Chinese Aphasia Test (CCAT) at 3 different time points: before treatment, 1 day and 3 months after the completion of treatment.","virtual reality aphasia language rehabilitation stroke","Interventional","Inclusion Criteria: +"15",11,"Establishment of Virtual Reality System for Stroke Patients With Aphasia","Aphasia","April 7, 2022","NCT05606393","Taipei Veterans General Hospital, Taiwan Taipei city NA Taiwan","Taipei Veterans General Hospital, Taiwan","Recruiting","Aphasia can significantly influence a person's social relationship and quality of life. To achieve positive language outcomes, an intensive and high-repetition speech therapy is essential. However, due to the limited number of speech therapists, the intensity and frequency of training are often insufficient. Therefore, it is critical to develop other rehabilitation approaches to enhance the benefits of aphasia intervention. Virtual reality (VR) is an immersive and interactive computer simulation technology that can promote the ecological validity of speech therapy. In this study, we develop an innovative VR software for speech training to explore the effects of VR on various aspects of language outcomes.","We randomly assigned study participants into 2 groups: the traditional speech therapy (ST) group and the traditional ST with additional VR training (ST+VR) group. In the ST group, each participant received 1-hour traditional ST for each session. In the ST+VR group, an additional 30-minute VR training was administered immediately after each session of traditional ST. All participants received 3 sessions of treatment every week for 3 weeks. For outcome measurement, we administered Concise Chinese Aphasia Test (CCAT) at 3 different time points: before treatment, 1 day and 3 months after the completion of treatment.","virtual reality aphasia language rehabilitation stroke","Interventional","Inclusion Criteria: Diagnosis of stroke with aphasia, including fluent and non-fluent types Age between 20~80-year-old @@ -374,7 +355,7 @@ Unable to learn how to use the virtual reality controller and device Any medical diseases or unstable vital signs that may cause safety concern Severe hearing or vision impairments Have ever received any form of speech therapy or virtual reality training","No","20 Years","All","Taipei city",NA,NA,NA,"Taiwan",1,"no",121.519937,25.1193725,2022-04-07 -"17",13,"Efficacy of Low-frequency rTMS in Aphasia","Aphasia","July 18, 2022","NCT05450341","Medipol University Istanbul NA Turkey","Medipol University","Recruiting","In a randomized controlled trial, efficacy of low-frequency, inhibitory rTMS will be examined in rehabilitation of acquired aphasia. Two cortical sites will be targeted: Right-hemispheric homologues of Broca's and Wernicke's areas. +"16",12,"Efficacy of Low-frequency rTMS in Aphasia","Aphasia","July 18, 2022","NCT05450341","Medipol University Istanbul NA Turkey","Medipol University","Recruiting","In a randomized controlled trial, efficacy of low-frequency, inhibitory rTMS will be examined in rehabilitation of acquired aphasia. Two cortical sites will be targeted: Right-hemispheric homologues of Broca's and Wernicke's areas. In addition to cognitive screening prior to onset of rTMS, language assessments will be conducted before, during and after the intervention. An eyetracking-while-listening experiment will also be conducted before and after the intervention to investigate morphosyntactic processing.","Efficacy of low-frequency (1hz), inhibitory rTMS will be examined in rehabilitation of acquired aphasia. Two cortical sites will be targeted: Right-hemispheric homologues of Broca's and Wernicke's areas. In other words, right frontal and right temporal sites will be targeted. @@ -399,7 +380,7 @@ Violating current TMS safety guidelines (Rossi et al. 2009, 2021). In other word Having a previous history of epilepsy, Having an implant (e.g., cochlear implant) or stimulator (e.g., deep brain stimulation) in the head which may interact with the magnetic field, Taking central nervous system active drugs that lower seizure threshold (as listed in the aforementioned guidelines)","No","18 Years","All","Istanbul","34815",NA,"Talat Bulut","Turkey",1,"no",28.942965,41.020518,2022-07-18 -"18",14,"Effects of Neuronavigated Theta Burst Stimulation in Therapy of Post-stroke Aphasia","Stroke, Ischemic Aphasia Non Fluent","September 2, 2022","NCT05303649","Institute of Psychiatry and Neurology, Warsaw Warsaw Masovian Voivodeship Poland","Institute of Psychiatry and Neurology, Warsaw","Recruiting","Aphasia is an impairment in the ability to express and/or understand language, commonly observed after stroke to the language dominant (left) hemisphere. Despite natural tendency to spontaneous functional recovery in the first months post stroke and language improvement due to application of behavioral speech and language therapy (SLT), many aphasic patients do not achieve satisfactory level of verbal communication. The aim of the planned study is to explore the potential of the noninvasive repetitive Transcranial Magnetic Stimulation (rTMS) as a therapeutic tool for aphasia in addition to traditional behavioral therapy. In case of aphasia, studies on therapeutic effectiveness of rTMS aim to increase the activity of the language-dominant left cerebral hemisphere, which may be achieved in an indirect manner by inhibiting the activity of the opposite (right) hemisphere or in a direct manner by increasing the excitability of preserved language areas in the left hemisphere. In our study, we plan to administer the newest form of rTMS called Theta Burst Stimulation (TBS), which is safer than the conventional rTMS, even when used in the perilesional area. Computer-based neuronavigation system will be implemented to precisely localize stimulation targets, control administration of stimuli during rTMS sessions, and evaluate differences between participants regarding deviations from established stimulation points. 45 patients (all right-handed, polish native speakers, aged 18-75 years, diagnosed with non-fluent aphasia) will be enrolled in a randomized, double-blind, sham-controlled trial. Subjects will be randomly assigned to one of the three groups: 1) a group with excitatory intermittent TBS of the left hemisphere (iTBS group), 2) a group with inhibitory continuous TBS of the right hemisphere (cTBS group), 3) a group with sham TBS (sTBS group as a control group). Specific forms of stimulation will be carried out for three consecutive weeks (Monday to Friday; a total of 15 stimulation sessions). Immediately after each session of the stimulation, patients will undergo individual SLT. Assessment of language functioning will be carried out three times: before and after the therapy period, and 3 months after its completion. Results of the study will broaden knowledge about hemispherical mechanisms of language and speech recovery after stroke and provide insight into possibilities of their modulation for the purpose of post-stroke rehabilitation.",NA,"Aphasia Stroke Theta Burst Stimulation Therapy Rehabilitation Noninvasive Transcranial Brain Stimulation","Interventional","Inclusion Criteria: +"17",13,"Effects of Neuronavigated Theta Burst Stimulation in Therapy of Post-stroke Aphasia","Stroke, Ischemic Aphasia Non Fluent","September 2, 2022","NCT05303649","Institute of Psychiatry and Neurology, Warsaw Warsaw Masovian Voivodeship Poland","Institute of Psychiatry and Neurology, Warsaw","Recruiting","Aphasia is an impairment in the ability to express and/or understand language, commonly observed after stroke to the language dominant (left) hemisphere. Despite natural tendency to spontaneous functional recovery in the first months post stroke and language improvement due to application of behavioral speech and language therapy (SLT), many aphasic patients do not achieve satisfactory level of verbal communication. The aim of the planned study is to explore the potential of the noninvasive repetitive Transcranial Magnetic Stimulation (rTMS) as a therapeutic tool for aphasia in addition to traditional behavioral therapy. In case of aphasia, studies on therapeutic effectiveness of rTMS aim to increase the activity of the language-dominant left cerebral hemisphere, which may be achieved in an indirect manner by inhibiting the activity of the opposite (right) hemisphere or in a direct manner by increasing the excitability of preserved language areas in the left hemisphere. In our study, we plan to administer the newest form of rTMS called Theta Burst Stimulation (TBS), which is safer than the conventional rTMS, even when used in the perilesional area. Computer-based neuronavigation system will be implemented to precisely localize stimulation targets, control administration of stimuli during rTMS sessions, and evaluate differences between participants regarding deviations from established stimulation points. 45 patients (all right-handed, polish native speakers, aged 18-75 years, diagnosed with non-fluent aphasia) will be enrolled in a randomized, double-blind, sham-controlled trial. Subjects will be randomly assigned to one of the three groups: 1) a group with excitatory intermittent TBS of the left hemisphere (iTBS group), 2) a group with inhibitory continuous TBS of the right hemisphere (cTBS group), 3) a group with sham TBS (sTBS group as a control group). Specific forms of stimulation will be carried out for three consecutive weeks (Monday to Friday; a total of 15 stimulation sessions). Immediately after each session of the stimulation, patients will undergo individual SLT. Assessment of language functioning will be carried out three times: before and after the therapy period, and 3 months after its completion. Results of the study will broaden knowledge about hemispherical mechanisms of language and speech recovery after stroke and provide insight into possibilities of their modulation for the purpose of post-stroke rehabilitation.",NA,"Aphasia Stroke Theta Burst Stimulation Therapy Rehabilitation Noninvasive Transcranial Brain Stimulation","Interventional","Inclusion Criteria: First-ever left middle cerebral artery ischemic stroke (brain damage localization confirmed by magnetic resonance imaging, MRI) 3 or more months from the onset of stroke @@ -418,7 +399,7 @@ Regular intake of medication that could affect cortical excitability (e. g. anti Significant cognitive impairment limiting patient's cooperation during assessment and behavioral aphasia therapy Visual deficits significantly hindering the perception of therapeutic tasks presented visually on a computer's screen New neurological episode (e. g. another brain stroke) or somatic illness (e. g. COVID-19) during the cycle of the therapy, requiring its interruption.","No","18 Years","All","Warsaw",NA,"Masovian Voivodeship","Katarzyna Polanowska","Poland",1,"no",21.064189,52.172273,2022-09-02 -"19",16,"Efficacy of Language Games as Therapy for Post Stroke Aphasia","Stroke Aphasia","August 2015","NCT02458222","University of Birmingham Birmingham West Midlands United Kingdom","University of Birmingham","Recruiting","Aphasia is a language impairment experienced by about one third of stroke patients. This often devastating condition is treated by speech and language therapists (SLTs). There is evidence that language games delivered at the right intensity are an efficacious means of improving communication for people with post stroke aphasia. However, it is unclear which mechanism of language facilitation used in a game works best. This study will provide evidence for the ""active ingredient"" of a game, together with measures of efficacy, feasibility and enjoyment compared to standard aphasia therapy.","Aphasia is a language impairment experienced by about one third of stroke patients. This often devastating condition is treated by speech and language therapists (SLTs). There is evidence that language games delivered at the right intensity are an efficacious means of improving communication for people with post stroke aphasia. However, it is unclear which mechanism of language facilitation used in a game works best. This study will provide evidence for the ""active ingredient"" of a game, together with measures of efficacy, feasibility and enjoyment compared to standard aphasia therapy. +"18",15,"Efficacy of Language Games as Therapy for Post Stroke Aphasia","Stroke Aphasia","August 2015","NCT02458222","University of Birmingham Birmingham West Midlands United Kingdom","University of Birmingham","Recruiting","Aphasia is a language impairment experienced by about one third of stroke patients. This often devastating condition is treated by speech and language therapists (SLTs). There is evidence that language games delivered at the right intensity are an efficacious means of improving communication for people with post stroke aphasia. However, it is unclear which mechanism of language facilitation used in a game works best. This study will provide evidence for the ""active ingredient"" of a game, together with measures of efficacy, feasibility and enjoyment compared to standard aphasia therapy.","Aphasia is a language impairment experienced by about one third of stroke patients. This often devastating condition is treated by speech and language therapists (SLTs). There is evidence that language games delivered at the right intensity are an efficacious means of improving communication for people with post stroke aphasia. However, it is unclear which mechanism of language facilitation used in a game works best. This study will provide evidence for the ""active ingredient"" of a game, together with measures of efficacy, feasibility and enjoyment compared to standard aphasia therapy. Participants with moderate-severe difficulties will play picture naming games, involving self-cuing using gesture and circumlocution. Those with mild difficulties will play story-telling games, using similar self-cuing techniques. Change in language performance will be measured and compared to that achieved by the same participants following an episode of standard aphasia therapy from their local SLT (i.e. normal care). @@ -431,7 +412,7 @@ Adults who have suffered a stroke a minimum of 2 months prior to commencement of Exclusion Criteria: Severe perceptual or cognitive deficits. History of other neurological, psychiatric or neurodegenerative disease impairing language or communicative ability. Severe visual agnosia. Severe limb apraxia. Severe dysarthria. Drug or alcohol abuse.","No","18 Years","All","Birmingham","B13 8JL","West Midlands",NA,"United Kingdom",1,"no",-1.9305515,52.450079,2015-08-20 -"20",17,"Sentence Production Training in Aphasia","Aphasia","August 1, 2021","NCT05415501","Purdue University West Lafayette Indiana United States","Purdue University","Recruiting","This study focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming. First set of experiments will aim examine which priming conditions are most effective in creating maximal learning effects. Then, in a later experiment, the investigators will develop and test the efficacy of a novel treatment study based on findings from the first set of the experiments.","Over five years, the investigators will conduct a series of studies to develop a novel intervention strategy for improving sentence production and comprehension in persons with aphasia. Specifically, the investigators will use implicit priming as a novel facilitator for language recovery in aphasia. The planned studies seek to test the hypothesis that implicit priming alters the central language system in PWA, creating lasting and generalized improvements in both sentence production and comprehension. Aim 1 will determine the extent to which different manipulations of priming conditions modulate immediate and long-term improvement in sentence production. The investigators integrate multiple theories of language learning and apply them to make predictions about the trajectory of priming-induced learning in PWA. In Aim 2, using a set of eyetracking sentence comprehension tasks, it will be investigated whether the effects of priming in production generalize to off-line (accuracy) and on-line (eye fixations) sentence comprehension and determine what learning conditions result in greater cross-modality generalization. In Aim 3, the investigators will develop and establish Phase I efficacy data of an implicit priming treatment, incorporating the crucial learning conditions supporting maximal retention from Aims 1 and 2. The project will recruit both individuals with aphasia and without aphasia.","aphasia training aphasia treatment","Interventional","Inclusion Criteria: +"19",16,"Sentence Production Training in Aphasia","Aphasia","August 1, 2021","NCT05415501","Purdue University West Lafayette Indiana United States","Purdue University","Recruiting","This study focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming. First set of experiments will aim examine which priming conditions are most effective in creating maximal learning effects. Then, in a later experiment, the investigators will develop and test the efficacy of a novel treatment study based on findings from the first set of the experiments.","Over five years, the investigators will conduct a series of studies to develop a novel intervention strategy for improving sentence production and comprehension in persons with aphasia. Specifically, the investigators will use implicit priming as a novel facilitator for language recovery in aphasia. The planned studies seek to test the hypothesis that implicit priming alters the central language system in PWA, creating lasting and generalized improvements in both sentence production and comprehension. Aim 1 will determine the extent to which different manipulations of priming conditions modulate immediate and long-term improvement in sentence production. The investigators integrate multiple theories of language learning and apply them to make predictions about the trajectory of priming-induced learning in PWA. In Aim 2, using a set of eyetracking sentence comprehension tasks, it will be investigated whether the effects of priming in production generalize to off-line (accuracy) and on-line (eye fixations) sentence comprehension and determine what learning conditions result in greater cross-modality generalization. In Aim 3, the investigators will develop and establish Phase I efficacy data of an implicit priming treatment, incorporating the crucial learning conditions supporting maximal retention from Aims 1 and 2. The project will recruit both individuals with aphasia and without aphasia.","aphasia training aphasia treatment","Interventional","Inclusion Criteria: Individuals with post-stroke aphasia At least 6 months post-onset of eft hemisphere stroke @@ -446,7 +427,7 @@ Severe apraxia of speech Other neurological conditions affecting communication (e.g., dementia) Uncontrolled psychiatric/psychological conditions affecting thinking and communication Active alcohol/substance abuse","Accepts Healthy Volunteers","21 Years","All","West Lafayette","47907","Indiana","Ji Yeon Lee","United States",1,"no",-86.92597925,40.426348,2021-08-01 -"21",19,"Virtual Reality Training for Aphasia Rehabilitation","Anomic Aphasia","April 2023","NCT05793879","Catholic University of the Sacred Heart Brescia NA Italy","Catholic University of the Sacred Heart","Recruiting","Aphasia is an acquired deficit following acute damage to the central nervous system that involves the difficulty or impossibility of understanding and formulating language. A typical disorder of non-fluent forms of aphasia is anomia. Anomia refers to the difficulty in finding words, in particular when trying to name objects and actions. According to the Embodied Cognition approach (EC), language is tightly connected to the motor system. In this view, language rehabilitation programs should stimulate language through the activation of the motor system. In this approach, since anomic deficits are often due to a weak link between the meaning of the word and its lemma, the Hebbs' principles of coincident and correlated learning can be exploited, i.e., by intensifying the synchronous activation of lexicon and semantics and connecting them with the motor counterpart. In this study, the investigators present an innovative training, based on the EC framework, in which they will make use of new technologies for anomia rehabilitation in post-stroke patients. Specifically, the researchers will use immersive 360° videos representing everyday actions displayed from the first-person point of view, experienced through a head-mounted display. The training will be administered 3 times a week for 4 weeks. The control group will watch standard videos representing the same actions recorded from the third-person perspective. Naming abilities will be tested before and after the training together with other cognitive and psychological measures. The investigators expect that the group who will undergo the 360° video-based training will show greater improvement of performance compared to the control group.",NA,"virtual reality embodied cognition rehabilitation","Interventional","Inclusion Criteria: +"20",18,"Virtual Reality Training for Aphasia Rehabilitation","Anomic Aphasia","April 2023","NCT05793879","Catholic University of the Sacred Heart Brescia NA Italy","Catholic University of the Sacred Heart","Recruiting","Aphasia is an acquired deficit following acute damage to the central nervous system that involves the difficulty or impossibility of understanding and formulating language. A typical disorder of non-fluent forms of aphasia is anomia. Anomia refers to the difficulty in finding words, in particular when trying to name objects and actions. According to the Embodied Cognition approach (EC), language is tightly connected to the motor system. In this view, language rehabilitation programs should stimulate language through the activation of the motor system. In this approach, since anomic deficits are often due to a weak link between the meaning of the word and its lemma, the Hebbs' principles of coincident and correlated learning can be exploited, i.e., by intensifying the synchronous activation of lexicon and semantics and connecting them with the motor counterpart. In this study, the investigators present an innovative training, based on the EC framework, in which they will make use of new technologies for anomia rehabilitation in post-stroke patients. Specifically, the researchers will use immersive 360° videos representing everyday actions displayed from the first-person point of view, experienced through a head-mounted display. The training will be administered 3 times a week for 4 weeks. The control group will watch standard videos representing the same actions recorded from the third-person perspective. Naming abilities will be tested before and after the training together with other cognitive and psychological measures. The investigators expect that the group who will undergo the 360° video-based training will show greater improvement of performance compared to the control group.",NA,"virtual reality embodied cognition rehabilitation","Interventional","Inclusion Criteria: naming disorder in the post-acute phase (index event occurring at least 6 months earlier) to have already received rehabilitation treatment in the acute phase @@ -459,14 +440,14 @@ concomitant or pre-existing (with respect to the index event) neurological and p epilepsy balance disorders neglect","No","18 Years","All","Brescia","25123",NA,"Claudia Repetto","Italy",1,"no",139.7201515,35.651036,2023-04-20 -"22",20,"Neural Bases of Vocal Sensorimotor Impairment in Aphasia","Aphasia","July 11, 2021","NCT04742894","University of South Carolina Columbia South Carolina United States","University of South Carolina","Recruiting","Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control. While recovery can be promoted with speech therapy, improvement remains modest and typically requires a large number of sessions contributing to rising health care costs. Traditional aphasia therapy focus on enhancing speech motor output; however, recent evidence suggests that the auditory feedback also plays a critical role in fluent speech. Therefore, a key step toward refining treatment strategies is to develop objective biomarkers that can probe the integrity of sensorimotor mechanisms of speech auditory feedback and identify their impaired function in patients with post-stroke aphasia. This study aims to examine the behavioral, neurophysiological (EEG), and neuroimaging (fMRI) biomarkers of speech impairment following stroke with focus on understanding the role of auditory feedback for speech production and control. We plan to test individuals with post-stroke aphasia and a matched neuroptypical control group during different speech production tasks under the altered auditory feedback paradigm. In addition, we aim to examine the effect of audio-visual feedback training on enhancing communication ability during speech. These biomarkers will be combined with existing lesion-symptom-mapping data in the aphasic group in order to identify the patterns of brain damage and diminished structural connectivity within the auditory-motor areas of the left hemisphere that predict impaired sensorimotor processing of speech in aphasia. The long-term goal of this research is to develop a model for identifying the source of sensorimotor deficit and improve diagnosis and targeted treatment of speech disorders in aphasia.",NA,"","Interventional","Inclusion Criteria: +"21",19,"Neural Bases of Vocal Sensorimotor Impairment in Aphasia","Aphasia","July 11, 2021","NCT04742894","University of South Carolina Columbia South Carolina United States","University of South Carolina","Recruiting","Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control. While recovery can be promoted with speech therapy, improvement remains modest and typically requires a large number of sessions contributing to rising health care costs. Traditional aphasia therapy focus on enhancing speech motor output; however, recent evidence suggests that the auditory feedback also plays a critical role in fluent speech. Therefore, a key step toward refining treatment strategies is to develop objective biomarkers that can probe the integrity of sensorimotor mechanisms of speech auditory feedback and identify their impaired function in patients with post-stroke aphasia. This study aims to examine the behavioral, neurophysiological (EEG), and neuroimaging (fMRI) biomarkers of speech impairment following stroke with focus on understanding the role of auditory feedback for speech production and control. We plan to test individuals with post-stroke aphasia and a matched neuroptypical control group during different speech production tasks under the altered auditory feedback paradigm. In addition, we aim to examine the effect of audio-visual feedback training on enhancing communication ability during speech. These biomarkers will be combined with existing lesion-symptom-mapping data in the aphasic group in order to identify the patterns of brain damage and diminished structural connectivity within the auditory-motor areas of the left hemisphere that predict impaired sensorimotor processing of speech in aphasia. The long-term goal of this research is to develop a model for identifying the source of sensorimotor deficit and improve diagnosis and targeted treatment of speech disorders in aphasia.",NA,"","Interventional","Inclusion Criteria: A total of 50 individuals with aphasia due to chronic left hemisphere stroke (> 6 months post-stroke) and 50 age- and gender-matched healthy control subjects will be recruited in this study. The general inclusion criteria for all subjects include: age range 21-75 years, right-handed, and native speaker of English. The aphasic subjects have previously undergone neuro-psychological speech/language testing and have been diagnosed with one type of aphasia (e.g., Broca's, Wernicke's, conduction or anomic). Subjects in the control group will meet the inclusion criteria with having normal voice, speech, language, and hearing function and no history of neurological and psychiatric disorder. We expect that a significant proportion of aphasic patients will show symptoms associated with Apraxia of Speech (AOS) or dysarthria; however, these patients will not be excluded unless their deficits will preclude them from performing the experimental tasks. Exclusion Criteria: Subjects with moderate to severe hearing, memory, and/or cognitive impairments will be excluded for both groups. In addition, subjects with history of peripheral laryngeal disorders (e.g., paresis or vocal fold paralysis) will be excluded. Subjects will undergo safety screening and will be excluded if there are any factors counter-indicative for EEG and/or MRI scanning.","Accepts Healthy Volunteers","21 Years","All","Columbia","29208","South Carolina","Roozbeh Behroozmand","United States",1,"no",-81.026403,33.997832,2021-07-11 -"23",21,"Word Retrieval in the Wild in People With Post-Stroke Aphasia","Aphasia, Acquired","December 19, 2022","NCT05338216","Northeastern University Boston Massachusetts United States","Northeastern University","Recruiting","People with post-stroke aphasia (PWA) suffer from anomia, a condition where they know what they want to say but cannot retrieve the words. For PWA, word retrieval changes moment-to-moment, leading to diminished motivation to participate in conversations and disengagement from social interactions. In the real world, anomia variability and severity are compounded by contextual factors of communication exchanges (noise, dual-tasking). Ecological momentary assessment (EMA) involves in-situ measurement of a behavior over time during everyday life. EMA has promise for capturing real-world anomia, yet EMA methods have not been tested in PWA. Therefore, the aims of this pilot study are to (1) determine the relative feasibility of two types of smartwatch-delivered EMA (traditional-EMA and micro-EMA) in PWA and (2) determine the extent to which patient-specific factors relate to feasibility. Twenty PWA will be recruited and randomly assigned to either traditional-EMA or micro-EMA conditions. To target in-situ anomia, PWA will complete 36 picture-naming trials/day for three weeks, delivered either as a single trial 36 times per day (micro-EMA) or in four sets of nine trials/set per day (traditional-EMA). Due to the ""at-a-glance"" single trial delivery of micro-EMA, the investigators hypothesize that PWA in the micro-EMA condition will demonstrate better protocol adherence than PWA in the traditional-EMA condition. Older age, more severe cognitive-linguistic deficits, and greater discomfort with technology will be related to poorer compliance, lower completion, greater perceived burden, and lower intelligibility of naming audio recordings. This bench-to-bedside research will begin a translational path to implement EMA/micro-EMA into routine assessment of aphasia.","BACKGROUND AND TRANSLATIONAL SIGNIFICANCE Background Approximately 15 million individuals worldwide, including 795,000 Americans, suffer a new stroke each year. Aphasia, a disorder characterized by receptive and/or expressive language deficits, affects approximately 30% of stroke survivors and is one of the most devastating post-stroke conditions. Aphasia is a heterogenous disorder, yet anomia (i.e., impaired word retrieval) is a persistent, ubiquitous impairment present in all people with aphasia (PWA). Neurotypical individuals occasionally experience anomia during ""tip-of-the-tongue"" moments: frustrating instances when someone knows what they want to say but the word itself eludes them. For the two million Americans currently living with aphasia, word retrieval difficulties are far more severe and pervade all communication attempts. Anomia severity ranges between PWA, from mild difficulties such as delayed retrieval of low frequency words (e.g., amulet) to severe difficulty retrieving the names of even common objects (e.g., bed). Yet, regardless of severity, a hallmark of post-stroke anomia is inconsistent word retrieval across attempts for a given word. For PWA, the ability to access words can change day-to-day and even minute-to-minute, resulting in diminished motivation to participate in conversations, disengagement from social interactions, and reduced quality of life. +"22",20,"Word Retrieval in the Wild in People With Post-Stroke Aphasia","Aphasia, Acquired","December 19, 2022","NCT05338216","Northeastern University Boston Massachusetts United States","Northeastern University","Recruiting","People with post-stroke aphasia (PWA) suffer from anomia, a condition where they know what they want to say but cannot retrieve the words. For PWA, word retrieval changes moment-to-moment, leading to diminished motivation to participate in conversations and disengagement from social interactions. In the real world, anomia variability and severity are compounded by contextual factors of communication exchanges (noise, dual-tasking). Ecological momentary assessment (EMA) involves in-situ measurement of a behavior over time during everyday life. EMA has promise for capturing real-world anomia, yet EMA methods have not been tested in PWA. Therefore, the aims of this pilot study are to (1) determine the relative feasibility of two types of smartwatch-delivered EMA (traditional-EMA and micro-EMA) in PWA and (2) determine the extent to which patient-specific factors relate to feasibility. Twenty PWA will be recruited and randomly assigned to either traditional-EMA or micro-EMA conditions. To target in-situ anomia, PWA will complete 36 picture-naming trials/day for three weeks, delivered either as a single trial 36 times per day (micro-EMA) or in four sets of nine trials/set per day (traditional-EMA). Due to the ""at-a-glance"" single trial delivery of micro-EMA, the investigators hypothesize that PWA in the micro-EMA condition will demonstrate better protocol adherence than PWA in the traditional-EMA condition. Older age, more severe cognitive-linguistic deficits, and greater discomfort with technology will be related to poorer compliance, lower completion, greater perceived burden, and lower intelligibility of naming audio recordings. This bench-to-bedside research will begin a translational path to implement EMA/micro-EMA into routine assessment of aphasia.","BACKGROUND AND TRANSLATIONAL SIGNIFICANCE Background Approximately 15 million individuals worldwide, including 795,000 Americans, suffer a new stroke each year. Aphasia, a disorder characterized by receptive and/or expressive language deficits, affects approximately 30% of stroke survivors and is one of the most devastating post-stroke conditions. Aphasia is a heterogenous disorder, yet anomia (i.e., impaired word retrieval) is a persistent, ubiquitous impairment present in all people with aphasia (PWA). Neurotypical individuals occasionally experience anomia during ""tip-of-the-tongue"" moments: frustrating instances when someone knows what they want to say but the word itself eludes them. For the two million Americans currently living with aphasia, word retrieval difficulties are far more severe and pervade all communication attempts. Anomia severity ranges between PWA, from mild difficulties such as delayed retrieval of low frequency words (e.g., amulet) to severe difficulty retrieving the names of even common objects (e.g., bed). Yet, regardless of severity, a hallmark of post-stroke anomia is inconsistent word retrieval across attempts for a given word. For PWA, the ability to access words can change day-to-day and even minute-to-minute, resulting in diminished motivation to participate in conversations, disengagement from social interactions, and reduced quality of life. Per psycholinguistic models of lexical access, naming is a two-step process that involves retrieval of the target's meaning from the semantic system and word form (speech sounds) from the phonological system. Naming failures in PWA result in errors that are related to a target word in meaning (e.g., ""carrot"" for bean), word form (e.g., ""fean"" for bean), both meaning and form (e.g., ""green"" for bean), or neither (e.g., ""pencil"" for bean; ""I know it but I can't say it"" for bean) due to insufficient activation of the target meaning/form representations or overactivation of incorrect representations. Due to this noisy system, lexical access is often delayed in PWA, even when the correct word is eventually retrieved. Naming accuracy, response times, and error types provide meaningful information regarding the locus of naming impairment and a patient's recovery capacity. The investigators found that the number of phonological and unrelated errors produced during early post-stroke stages predicted longitudinal changes in naming and global language skills in left hemisphere stroke survivors. Naming errors and the integrity of underlying semantic and phonological systems can also guide language treatment planning. As such, accurate assessment of naming is critical for aphasia care. @@ -527,7 +508,7 @@ Presence of aphasia Exclusion Criteria: History of neurological disease affecting the brain other than stroke","No","18 Years","All","Boston","02115","Massachusetts",NA,"United States",1,"no",-71.0883555,42.3397355,2022-12-19 -"24",22,"Semantic Feature Analysis Treatment for Aphasia","Aphasia","February 24, 2020","NCT04215952","VA Pittsburgh Healthcare System Pittsburgh Pennsylvania United States","VA Pittsburgh Healthcare System","Recruiting","This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of treatment success. Study participants will be randomly assigned to one of two treatment conditions comparing two different versions of Semantic Feature Analysis treatment. Their performance on standardized and study-specific measures will be used to determine which version of the treatment provides superior outcomes, and measures of automatic language processing and functional brain imaging will also be used to identify the underlying neurocognitive mechanisms associated with positive treatment response.","This randomized comparative effectiveness trial examines whether active manipulation of a key component of semantic feature analysis (SFA) treatment for word-finding difficulty in aphasia improves outcomes. 40 study participants will be recruited and randomized to receive one of the two versions of the treatment. The total treatment time will be equated in the two conditions. +"23",21,"Semantic Feature Analysis Treatment for Aphasia","Aphasia","February 24, 2020","NCT04215952","VA Pittsburgh Healthcare System Pittsburgh Pennsylvania United States","VA Pittsburgh Healthcare System","Recruiting","This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of treatment success. Study participants will be randomly assigned to one of two treatment conditions comparing two different versions of Semantic Feature Analysis treatment. Their performance on standardized and study-specific measures will be used to determine which version of the treatment provides superior outcomes, and measures of automatic language processing and functional brain imaging will also be used to identify the underlying neurocognitive mechanisms associated with positive treatment response.","This randomized comparative effectiveness trial examines whether active manipulation of a key component of semantic feature analysis (SFA) treatment for word-finding difficulty in aphasia improves outcomes. 40 study participants will be recruited and randomized to receive one of the two versions of the treatment. The total treatment time will be equated in the two conditions. Study participants will be housed locally at the Pittsburgh site at no cost and will be eligible to receive reimbursement for travel expenses. During the five-week treatment phase of the study, participants will receive 60 hours of SFA treatment with pre- and post-treatment assessment of their ability to name pictures of treated and untreated, semantically related nouns. Other secondary outcomes, including measures of connected speech and patient-reported communication ability will also be collected. In order to address unresolved questions about the underlying cognitive and neural mechanisms of SFA, participants will also receive concurrent pre- and post-treatment assessment of automatic word processing ability using eye-tracking methods and functional magnetic resonance imaging (fMRI). Participants will also be asked to return to Pittsburgh for two days approximately 2-3 months later for follow-up language, eye-tracking, and fMRI testing. @@ -548,7 +529,7 @@ Neurological disease other than stroke Significant psychiatric disorder Severe motor speech disorder Active substance dependence","No","18 Years","All","Pittsburgh","15240","Pennsylvania",NA,"United States",1,"no",-79.961502,40.446625,2020-02-24 -"25",24,"Theory-Driven Treatment of Language and Cognitive Processes in Aphasia","Aphasia","March 2014","NCT02664506","Temple University Philadelphia Pennsylvania United States","Temple University","Recruiting","The aim of this research is to translate a theory of the cognitive relationship between verbal short--term memory (STM) and word processing impairments in aphasia to treatment approaches for language impairment in aphasia. It has been proposed that the co-occurrence of these impairments is due to a disruption of cognitive processes that support both abilities: maintenance of activated semantic and phonological representations of words, hereafter the 'activation--maintenance hypothesis'. +"24",23,"Theory-Driven Treatment of Language and Cognitive Processes in Aphasia","Aphasia","March 2014","NCT02664506","Temple University Philadelphia Pennsylvania United States","Temple University","Recruiting","The aim of this research is to translate a theory of the cognitive relationship between verbal short--term memory (STM) and word processing impairments in aphasia to treatment approaches for language impairment in aphasia. It has been proposed that the co-occurrence of these impairments is due to a disruption of cognitive processes that support both abilities: maintenance of activated semantic and phonological representations of words, hereafter the 'activation--maintenance hypothesis'. This hypothesis will be tested in the context of a treatment approach that aims to improve word processing and verbal STM abilities.","Based on research of word processing and verbal STM impairments in aphasia, it has been proposed that the co-occurrence of these impairments is due to a disruption of cognitive processes that support both abilities: maintenance of activated semantic and phonological representations of words, hereafter the 'activation--maintenance hypothesis'. @@ -588,7 +569,7 @@ Exclusion Criteria: History of neurological disease or language disability Histories for mental illness Alcohol/substance abuse.","Accepts Healthy Volunteers","21 Years","All","Philadelphia","19121","Pennsylvania","Nadine Martin","United States",1,"no",-75.155202,39.9808005,2014-03-20 -"26",25,"Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia","Aphasia","March 28, 2019","NCT03651700","University of Pennsylvania Philadelphia Pennsylvania United States","University of Pennsylvania","Recruiting","Transcranial Magnetic Stimulation (TMS) has been demonstrated to improve language function in subjects with chronic aphasia in a number of small studies, many of which did not include a control group. Although the treatment appears promising, data to date do not permit an adequate assessment of the utility of the technique. The investigators propose to study the effects of TMS combined with Constraint Induced Language Therapy (CILT) in 75 subjects with chronic aphasia. Subjects will be randomized in a 2:1 ratio to TMS with CILT or sham TMS with CILT. One Hz TMS at 90% motor threshold will be delivered to the right inferior frontal gyrus for 20 minutes in 10 sessions over 2 weeks; language therapy will be provided for one hour immediately after the conclusion of each session of TMS. Change from baseline in the Western Aphasia Battery Aphasia Quotient at 6 months after the end of TMS treatment will serve as the primary outcome measure. A secondary aim is to identify anatomic and behavioral predictors of response to treatment. Finally, a third aim is to identify the mechanism underlying the beneficial effect of the treatment using a variety of imaging techniques. Subjects who have no contraindication to the MRI will undergo fMRI imaging prior to and at 6 months after therapy. Using modern network analyses and robust machine learning techniques, the investigators will identify changes in the strengths of connections between nodes in the language network to address specific hypotheses regarding the effects of TMS and CILT on brain organization that are associated with beneficial response to treatment.","TMS is a technique by which a brief electrical current is induced in brain tissue causing a brief suppression of the excitability of the underlying tissue; the technique, which was introduced in the 1980s and has been extensively used around the world, has been shown to transiently improve or disrupt specific cognitive operations. To achieve this end, a coil is positioned against the subject's head. The delivery of a single pulse begins with the discharge of current from a capacitor into a circular or figure-of-eight coil; this electrical current generates a brief magnetic field of up to 2.2 Tesla. As the pulse of electricity has a rise time of 0.2 ms. and a duration of 1 ms., the magnetic field changes in intensity quite rapidly. Because the magnetic field passes freely through the scalp, skull, and meninges, the flux in the magnetic field induces a small electric field in the brain that transiently alters neural activity. +"25",24,"Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia","Aphasia","March 28, 2019","NCT03651700","University of Pennsylvania Philadelphia Pennsylvania United States","University of Pennsylvania","Recruiting","Transcranial Magnetic Stimulation (TMS) has been demonstrated to improve language function in subjects with chronic aphasia in a number of small studies, many of which did not include a control group. Although the treatment appears promising, data to date do not permit an adequate assessment of the utility of the technique. The investigators propose to study the effects of TMS combined with Constraint Induced Language Therapy (CILT) in 75 subjects with chronic aphasia. Subjects will be randomized in a 2:1 ratio to TMS with CILT or sham TMS with CILT. One Hz TMS at 90% motor threshold will be delivered to the right inferior frontal gyrus for 20 minutes in 10 sessions over 2 weeks; language therapy will be provided for one hour immediately after the conclusion of each session of TMS. Change from baseline in the Western Aphasia Battery Aphasia Quotient at 6 months after the end of TMS treatment will serve as the primary outcome measure. A secondary aim is to identify anatomic and behavioral predictors of response to treatment. Finally, a third aim is to identify the mechanism underlying the beneficial effect of the treatment using a variety of imaging techniques. Subjects who have no contraindication to the MRI will undergo fMRI imaging prior to and at 6 months after therapy. Using modern network analyses and robust machine learning techniques, the investigators will identify changes in the strengths of connections between nodes in the language network to address specific hypotheses regarding the effects of TMS and CILT on brain organization that are associated with beneficial response to treatment.","TMS is a technique by which a brief electrical current is induced in brain tissue causing a brief suppression of the excitability of the underlying tissue; the technique, which was introduced in the 1980s and has been extensively used around the world, has been shown to transiently improve or disrupt specific cognitive operations. To achieve this end, a coil is positioned against the subject's head. The delivery of a single pulse begins with the discharge of current from a capacitor into a circular or figure-of-eight coil; this electrical current generates a brief magnetic field of up to 2.2 Tesla. As the pulse of electricity has a rise time of 0.2 ms. and a duration of 1 ms., the magnetic field changes in intensity quite rapidly. Because the magnetic field passes freely through the scalp, skull, and meninges, the flux in the magnetic field induces a small electric field in the brain that transiently alters neural activity. TMS may be delivered in a variety of ways. The investigators propose to use 1 Hz TMS; that is, TMS pulses will be delivered at a frequency of 1/second. This style of TMS is assumed to be inhibitory in that it transiently suppresses the function of the cortex under the coil. Using the figure-of-eight coil to be employed here, TMS is thought to reduce activity in approximately 1 cubic cm. of cortex. Many investigators have employed TMS with a frequency of 1 Hz for periods of 20 minutes and longer; mild behavioral deficits are often present for several minutes in these studies. @@ -612,7 +593,7 @@ Previous head trauma with loss of consciousness for more than 5 minutes Psychiatric illness (We note that subjects will be assessed with the 15-item Geriatric Depression scale. Because depression is very difficult to evaluate in aphasic subjects, potential subjects will not be excluded on the basis of the depression score) Chronic exposure to medications that might be expected to have lasting consequences for the central nervous system (e.g. haloperidol, dopaminergics) History of or neuropsychological findings suggestive of dementia","No","18 Years","All","Philadelphia","19104","Pennsylvania","H. Branch Coslett","United States",1,"no",-75.1940565,39.9529705,2019-03-28 -"27",26,"Efficacy of a Combined Linguistic/Communication Therapy in Acute Aphasia After Stroke","Aphasia, Acquired","March 1, 2018","NCT03287544","University Hospital, Toulouse Toulouse Midi-Pyrénées France","University Hospital, Toulouse","Recruiting","Linguistic training is traditionally the gold standard for rehabilitation of aphasia after stroke and efficacy criteria count early stage, intensity as well as personalized treatment. To date, no clear evidence showed a specific effect of any therapy in the acute phase of aphasia after stroke. This study aims to compare the effect of a combined therapy (linguistic/communication) versus a linguistic therapy on communication performance in patients in the acute phase of aphasia after a first stroke.","Twenty to 25% of strokes cause aphasia. Speech and language therapy is the well-known standard treatment of aphasia after stroke although it is based on weak scientific evidence. To date, the efficacy criteria of aphasia rehabilitation are early stage, intensity as well as personalized treatment. Usually these patients receive in acute phase a linguistic training focused on the linguistic impairment. This approach is based on the cerebral plasticity postulate. However the superiority of this practice compared to other methods has never been shown. Moreover the benefit of the combination gathering linguistic treatment with communication treatment has to our knowledge never been studied. +"26",25,"Efficacy of a Combined Linguistic/Communication Therapy in Acute Aphasia After Stroke","Aphasia, Acquired","March 1, 2018","NCT03287544","University Hospital, Toulouse Toulouse Midi-Pyrénées France","University Hospital, Toulouse","Recruiting","Linguistic training is traditionally the gold standard for rehabilitation of aphasia after stroke and efficacy criteria count early stage, intensity as well as personalized treatment. To date, no clear evidence showed a specific effect of any therapy in the acute phase of aphasia after stroke. This study aims to compare the effect of a combined therapy (linguistic/communication) versus a linguistic therapy on communication performance in patients in the acute phase of aphasia after a first stroke.","Twenty to 25% of strokes cause aphasia. Speech and language therapy is the well-known standard treatment of aphasia after stroke although it is based on weak scientific evidence. To date, the efficacy criteria of aphasia rehabilitation are early stage, intensity as well as personalized treatment. Usually these patients receive in acute phase a linguistic training focused on the linguistic impairment. This approach is based on the cerebral plasticity postulate. However the superiority of this practice compared to other methods has never been shown. Moreover the benefit of the combination gathering linguistic treatment with communication treatment has to our knowledge never been studied. In the present study investigators propose to compare the effect of a combined linguistic/communication rehabilitation versus a linguistic treatment. To do so, investigators will recruit patients with aphasia after a first stroke, in the acute phase. After a allocation to the "" combined "" and "" linguistic "" groups, all the patients will have a comprehensive language and neuropsychological assessment before and after 3 months of rehabilitation, and finally 6 months after the onset. @@ -634,7 +615,7 @@ Uncorrected sensory impairment Evolutive pathology Adults protected by Law Participation to another research","No","18 Years","All","Toulouse","31059","Midi-Pyrénées",NA,"France",1,"no",1.444247,43.604462,2018-03-01 -"28",27,"Effects of rTMS Based on Hemodynamic Activity for Language Recovery in Early Poststroke Aphasia","Stroke Aphasia","November 2015","NCT02591719","Seoul National University Bundang Hospital Seongnam-si Korea, Gyeonggi-do Korea, Republic of","Seoul National University Bundang Hospital","Recruiting","The aim of this study is to assess the safety and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) based on hemodynamic brain activity pattern with functional near infrared spectroscopy (fNIRS) in early poststroke nonfluent aphasia patients.","Most conventional rTMS studies employed an inhibitory low frequency protocol for the contralesional homologs of Broca's area. +"27",26,"Effects of rTMS Based on Hemodynamic Activity for Language Recovery in Early Poststroke Aphasia","Stroke Aphasia","November 2015","NCT02591719","Seoul National University Bundang Hospital Seongnam-si Korea, Gyeonggi-do Korea, Republic of","Seoul National University Bundang Hospital","Recruiting","The aim of this study is to assess the safety and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) based on hemodynamic brain activity pattern with functional near infrared spectroscopy (fNIRS) in early poststroke nonfluent aphasia patients.","Most conventional rTMS studies employed an inhibitory low frequency protocol for the contralesional homologs of Broca's area. In the present randomized controlled trial, investigators will perform fNIRS prior to rTMS treatment to select the stimulation method. Stimulation site (perilesional or contralesional) and frequency (excitatory high or inhibitory low) will be determined by activation pattern from the fNIRS with language task in individual patients. @@ -658,7 +639,7 @@ Severe cognitive impairment (MMSE less than 16) Skin lesion in the stimulation site of scalp Metal implants in the body (cardiac pacemaker or aneurysm clip) Pregnancy, breastfeeding","No","18 Years","All","Seongnam-si","463-707","Korea, Gyeonggi-do","Nam-Jong Paik","Korea, Republic of",1,"no",127.1232505,37.351887,2015-11-20 -"29",28,"Neuro Device for Aphasia","Post-stroke Aphasia","August 2023","NCT05194566","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.","There are about 15 million strokes worldwide each year. Of this group, about 30% suffer from aphasia. Aphasia is a speech-language disorder associated with exceptional difficulty performing daily communication activities. If no improvement is observed within the first months after the stroke, a complete recovery is unlikely, and the therapy can last for years. +"28",27,"Neuro Device for Aphasia","Post-stroke Aphasia","August 2023","NCT05194566","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.","There are about 15 million strokes worldwide each year. Of this group, about 30% suffer from aphasia. Aphasia is a speech-language disorder associated with exceptional difficulty performing daily communication activities. If no improvement is observed within the first months after the stroke, a complete recovery is unlikely, and the therapy can last for years. Up to date, speech and language therapy is a standard of care for post-stroke aphasia, however the process is long and demanding. @@ -705,7 +686,7 @@ Withdrawal criteria: high intolerance to stimulation (participants experience severe discomfort during stimulation); occurrence of an epileptic seizure; other previously absent neurological, physical or mental symptoms.","No","18 Years","All","New York","10029","New York","Miguel Escalon","United States",1,"no",-73.953275,40.7898205,2023-08-20 -"30",29,"Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.","Stroke Aphasia","October 18, 2022","NCT04432883","University of New Mexico Albuquerque New Mexico United States","University of New Mexico","Recruiting","62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.","Our long-term goal is to develop safe and effective treatments for the communication problems of Aphasia due to stroke that restore patients to higher levels of functioning, decrease disability, and promote higher quality of life. While language therapy for aphasia is effective, improvements are typically slow, and gains may be small. Noninvasive brain stimulation has been suggested as a method to enhance outcomes from language therapy. This study will examine whether outcomes for language therapy with brain stimulation are different from outcomes for language therapy without brain stimulation in people with aphasia. Our central hypotheses are (1) targeted right hemisphere HDtDCS (RH-HD-tDCS) administered in combination with language treatment will result in greater changes in naming accuracy than language treatment with the sham RH-HD-tDCS (2) RH-HD-tDCS plus language treatment will result in greater increases in communication within the affected hemisphere compared to language treatment plus sham RH-HD-tDCS (3) RH-HD-tDCS plus language treatment will result in greater increases in perilesional areas working together immediately post-treatment compared to language treatment plus sham RH-HD-tDCS","Stroke Aphasia brain stimulation communication problems speech and language therapy","Interventional","Inclusion Criteria: +"29",28,"Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.","Stroke Aphasia","October 18, 2022","NCT04432883","University of New Mexico Albuquerque New Mexico United States","University of New Mexico","Recruiting","62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.","Our long-term goal is to develop safe and effective treatments for the communication problems of Aphasia due to stroke that restore patients to higher levels of functioning, decrease disability, and promote higher quality of life. While language therapy for aphasia is effective, improvements are typically slow, and gains may be small. Noninvasive brain stimulation has been suggested as a method to enhance outcomes from language therapy. This study will examine whether outcomes for language therapy with brain stimulation are different from outcomes for language therapy without brain stimulation in people with aphasia. Our central hypotheses are (1) targeted right hemisphere HDtDCS (RH-HD-tDCS) administered in combination with language treatment will result in greater changes in naming accuracy than language treatment with the sham RH-HD-tDCS (2) RH-HD-tDCS plus language treatment will result in greater increases in communication within the affected hemisphere compared to language treatment plus sham RH-HD-tDCS (3) RH-HD-tDCS plus language treatment will result in greater increases in perilesional areas working together immediately post-treatment compared to language treatment plus sham RH-HD-tDCS","Stroke Aphasia brain stimulation communication problems speech and language therapy","Interventional","Inclusion Criteria: aged 25-85 must be greater than 1 year post-stroke @@ -722,7 +703,7 @@ substance/alcohol dependence or abuse within the past year presence of any implanted electrical device or contraindications to tDCS or MRI recent medical instability (within 4 weeks) pregnancy","No","25 Years","All","Albuquerque","87106","New Mexico","Jessica Richardson","United States",1,"no",-106.6208755,35.083292,2022-10-18 -"31",30,"Studying Language With Brain Stimulation in Aphasia","Stroke Aphasia","January 9, 2023","NCT05660304","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The overall goal of this study is to evaluate whether stimulation of two brain areas alongside behavioral speech-language therapy increases connectivity to improve language functions in stroke-aphasia patients.","The brain is made up of networks that communicate with each other to help us think and communicate. After a stroke, networks between different areas of the brain can lose connection. In the case of aphasia, networks in the language areas of the brain are often disrupted. There is currently no ""fix"" to restore these specific language connections. However, transcranial magnetic stimulation (TMS) might help the areas reconnect through alternative pathways. +"30",29,"Studying Language With Brain Stimulation in Aphasia","Stroke Aphasia","January 9, 2023","NCT05660304","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The overall goal of this study is to evaluate whether stimulation of two brain areas alongside behavioral speech-language therapy increases connectivity to improve language functions in stroke-aphasia patients.","The brain is made up of networks that communicate with each other to help us think and communicate. After a stroke, networks between different areas of the brain can lose connection. In the case of aphasia, networks in the language areas of the brain are often disrupted. There is currently no ""fix"" to restore these specific language connections. However, transcranial magnetic stimulation (TMS) might help the areas reconnect through alternative pathways. TMS is a non-invasive procedure (in other words, it takes place outside your body). A coil will be placed over your head. The coil sends magnetic pulses to your brain to stimulate, or excite, neurons. Most studies using TMS stimulate one area of the brain at a time, but this does not tell us how to improve the network connections between brain areas. @@ -754,7 +735,7 @@ Ménière's disease Medications that increase risk of seizures, for instance antipsychotic and antidepressant medications acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants Non-prescribed drug use, for instance recreational marijuana Unable to refrain from using any alcohol and nicotine products for at least 24 hours before the study Visits.","No","18 Years","All","Chicago","60611","Illinois","Julio C Hernandez Pavon","United States",1,"no",-87.618428,41.893889,2023-01-09 -"32",31,"Genetic and Cognitive Predictors of Aphasia Treatment Response","Aphasia","October 23, 2020","NCT05179538","Ohio State University Columbus Ohio United States","Ohio State University","Recruiting","Aphasia, or language impairment after a stroke, affects approximately 2 million people in the United States, with an estimated 180,000 new cases each year. The medical community cannot predict how well someone with aphasia will respond to treatment, as some people with aphasia are poor responders to intervention even when participating in empirically supported treatments. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. This study will investigate whether two genes and cognitive abilities, such as memory, predict responsiveness to aphasia therapy for word-retrieval difficulties.","Incomplete understanding of patient-specific factors that determine whether someone will respond well to language therapy after stroke limits the development of methods to target or account for sources of variability. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. The long-term goal of this line of work is to maximize response to aphasia therapy by incorporating patient-specific factors into decisions related to treatment planning. The overall objective of this application is to identify patterns of patient-specific factors including two candidate genes and cognitive skills that show a relationship with treatment outcomes. The central hypothesis is that there will be a relationship between ApoE and BDNF genotypes, and working memory on stimulus generalization. The rationale for the proposed project is that the identification of factors that impact treatment responsiveness will allow for better estimation of prognosis, improved triage of individuals into appropriate therapy regimens and direct targeting of cognitive factors to maximize behavioral gains. The two specific aims of the project are to determine the degree to which (1) ApoE and BDNF genotypes influence how individuals with aphasia respond to therapy, and (2) working memory abilities are related to stimulus acquisition and stimulus generalization after anomia therapy. Individuals with chronic post-stroke aphasia will undergo cognitive and language assessment, and provide a saliva sample for genetic analysis prior to participating in a cued picture-naming therapy for anomia. The expected outcomes are to integrate cognitive scores and genotypes for BDNF and ApoE into formulating probabilities of individual patient responsiveness to restorative therapy. Improvement in word retrieval abilities will be evaluated using the percentage of pictures named correctly. This contribution is expected to be significant because it will allow for more informed clinical decision making and better allocation of resources to appropriate treatments, thereby making advances in the field toward more personalized medicine, as opposed to a one-size-fits-all clinical approach. +"31",30,"Genetic and Cognitive Predictors of Aphasia Treatment Response","Aphasia","October 23, 2020","NCT05179538","Ohio State University Columbus Ohio United States","Ohio State University","Recruiting","Aphasia, or language impairment after a stroke, affects approximately 2 million people in the United States, with an estimated 180,000 new cases each year. The medical community cannot predict how well someone with aphasia will respond to treatment, as some people with aphasia are poor responders to intervention even when participating in empirically supported treatments. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. This study will investigate whether two genes and cognitive abilities, such as memory, predict responsiveness to aphasia therapy for word-retrieval difficulties.","Incomplete understanding of patient-specific factors that determine whether someone will respond well to language therapy after stroke limits the development of methods to target or account for sources of variability. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. The long-term goal of this line of work is to maximize response to aphasia therapy by incorporating patient-specific factors into decisions related to treatment planning. The overall objective of this application is to identify patterns of patient-specific factors including two candidate genes and cognitive skills that show a relationship with treatment outcomes. The central hypothesis is that there will be a relationship between ApoE and BDNF genotypes, and working memory on stimulus generalization. The rationale for the proposed project is that the identification of factors that impact treatment responsiveness will allow for better estimation of prognosis, improved triage of individuals into appropriate therapy regimens and direct targeting of cognitive factors to maximize behavioral gains. The two specific aims of the project are to determine the degree to which (1) ApoE and BDNF genotypes influence how individuals with aphasia respond to therapy, and (2) working memory abilities are related to stimulus acquisition and stimulus generalization after anomia therapy. Individuals with chronic post-stroke aphasia will undergo cognitive and language assessment, and provide a saliva sample for genetic analysis prior to participating in a cued picture-naming therapy for anomia. The expected outcomes are to integrate cognitive scores and genotypes for BDNF and ApoE into formulating probabilities of individual patient responsiveness to restorative therapy. Improvement in word retrieval abilities will be evaluated using the percentage of pictures named correctly. This contribution is expected to be significant because it will allow for more informed clinical decision making and better allocation of resources to appropriate treatments, thereby making advances in the field toward more personalized medicine, as opposed to a one-size-fits-all clinical approach. The investigators will determine genotypes for BDNF and ApoE, which will yield four separate groups. At least 20 participants will be enrolled for each genotype group.","","Interventional","Inclusion Criteria: @@ -771,7 +752,7 @@ Severe depression. Diffuse injury or disease of the brain Uncorrected vision or hearing difficulties Contraindications for MRI (e.g. cardiac pacemaker, ferrous metal implants, claustrophobia, pregnancy).","No","18 Years","All","Columbus","43210","Ohio",NA,"United States",1,"no",-83.0122685,40.0010725,2020-10-23 -"33",33,"Stepped Care for Aphasia","Aphasia Stroke","March 31, 2023","NCT05851573","Medical University of South Carolina Charleston South Carolina United States","Medical University of South Carolina","Recruiting","This study is recruiting people who had a stroke at least 1 month ago and now have a language impairment called aphasia. Living with aphasia can have devastating effects on communication and quality of life, and it is not uncommon for survivors with aphasia to face psychological problems like depression and anxiety. Participants who are eligible for this study will undergo baseline testing, engage in a 5-week treatment focused on psychological well-being, undergo post-treatment testing, and then testing again 1-month later. Check-in phone calls will be conducted during the 1-month off period and participants will be interviewed about their experience at the end of the study as well. Compensation will be provided to participants with aphasia.",NA,"","Interventional","Inclusion Criteria: +"32",32,"Stepped Care for Aphasia","Aphasia Stroke","March 31, 2023","NCT05851573","Medical University of South Carolina Charleston South Carolina United States","Medical University of South Carolina","Recruiting","This study is recruiting people who had a stroke at least 1 month ago and now have a language impairment called aphasia. Living with aphasia can have devastating effects on communication and quality of life, and it is not uncommon for survivors with aphasia to face psychological problems like depression and anxiety. Participants who are eligible for this study will undergo baseline testing, engage in a 5-week treatment focused on psychological well-being, undergo post-treatment testing, and then testing again 1-month later. Check-in phone calls will be conducted during the 1-month off period and participants will be interviewed about their experience at the end of the study as well. Compensation will be provided to participants with aphasia.",NA,"","Interventional","Inclusion Criteria: 18-81 years old Native English speaker (English fluency by age 7) @@ -787,7 +768,7 @@ Uncorrected hearing or visual impairment that prevents completion of experimenta History of other neurological disorder or disease beside stroke (e.g., dementia, traumatic brain injury) as determined by self-report and/or medical records Self-reported history of premorbid learning disability Severe auditory comprehension deficits (as indicated by a score of more than two standard deviations below norms on the Auditory Verbal section of WAB-R)","No","18 Years","All","Charleston","29425","South Carolina","Deena Blackett","United States",1,"no",-79.947297,32.784808,2023-03-31 -"34",34,"Modulating Intensity and Dosage of Aphasia Scripts","Aphasia","September 21, 2020","NCT04138940","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The purpose of this study is to evaluate how changing conditions of speech-language treatment (namely, amount of repetition and distribution of practice schedule) affects the language outcome of participants with aphasia following a stroke. Using a computer based speech and language therapy program, participants will practice conversational scripts that are either short or long. Participants will practice for either 2 weeks (5 days a week) or for 5 weeks (2 days a week).","Determining the optimal intensity of treatment is essential to the design and implementation of any treatment program for aphasia. Yet, treatment intensity is a complex construct and information on the variables modulating it remain ambiguous and limited. Studies reported in the neuroscience and clinical literature support the need for intensive treatment to induce long-term neuroplastic changes while the cognitive psychology literature suggests that learning is best maintained with distributed schedules. A few studies have looked at dose parameters for single word naming tasks, but there is limited evidence regarding dose parameters for treatments that focus on training the production of larger units, such as sentences or even connected discourse. One approach that is frequently used clinically and has evidence for its efficacy is script training. Little is currently known regarding the optimum dose of script training (i.e., the number of repetitions over time of each sentence within the script) that is required to promote the best outcomes. +"33",33,"Modulating Intensity and Dosage of Aphasia Scripts","Aphasia","September 21, 2020","NCT04138940","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The purpose of this study is to evaluate how changing conditions of speech-language treatment (namely, amount of repetition and distribution of practice schedule) affects the language outcome of participants with aphasia following a stroke. Using a computer based speech and language therapy program, participants will practice conversational scripts that are either short or long. Participants will practice for either 2 weeks (5 days a week) or for 5 weeks (2 days a week).","Determining the optimal intensity of treatment is essential to the design and implementation of any treatment program for aphasia. Yet, treatment intensity is a complex construct and information on the variables modulating it remain ambiguous and limited. Studies reported in the neuroscience and clinical literature support the need for intensive treatment to induce long-term neuroplastic changes while the cognitive psychology literature suggests that learning is best maintained with distributed schedules. A few studies have looked at dose parameters for single word naming tasks, but there is limited evidence regarding dose parameters for treatments that focus on training the production of larger units, such as sentences or even connected discourse. One approach that is frequently used clinically and has evidence for its efficacy is script training. Little is currently known regarding the optimum dose of script training (i.e., the number of repetitions over time of each sentence within the script) that is required to promote the best outcomes. This study investigates the effects of modulating stimulus variables, specifically stimulus practice distribution and stimulus repetition. We use a baseline script treatment that has experimental support regarding its efficacy, and that allows the manipulation of these variables. To ensure independence and fidelity, treatment is provided in a controlled computer environment (desktop and tablet). To avoid clinician-related variables such as expertise and personality factors that may influence treatment, sentences are modeled during treatment by an anthropomorphic agent with high visual speech intelligibility and affective expressions. @@ -810,7 +791,7 @@ Exclusion Criteria: Any other neurological condition (other than cerebral vascular disease) that could potentially affect cognition or speech, such as Parkinson's Disease, Alzheimer's Dementia, traumatic brain injury Any significant psychiatric history prior to the stroke, such as severe major depression or psychotic disorder requiring hospitalization; subjects with mood disorders who are currently stable on treatment will be considered Active substance abuse","No","21 Years","All","Chicago","60611","Illinois","Leora Cherney","United States",1,"no",-87.618428,41.893889,2020-09-21 -"35",35,"High Definition Transcranial Alternating Current Stimulation (HD-tACS) for Post-stroke Aphasia","Transcranial Alternating Current Stimulation Post-stroke Aphasia Functional Magnetic Resonance Imaging","March 18, 2021","NCT05502822","Anhui Medical University Hefei NA China","Anhui Medical University","Recruiting","To investigate the intervention effect of high definition transcranial alternating current stimulation(HD-tACS) in chronic post-stroke aphasia and its underlying neural mechanism by MRI.","Aphasia is one of the most frequent cognitive deficits in poststroke survivor. More than 20% of stroke patients suffered from language impairment. The recovery of language dysfunction after stroke is highly variable. Some patients recover spontaneously in the early phases of stroke, but about two thirds of patients never fully restore language ability. The purpose of this study was to explore the intervention effect of high definition transcranial alternating current stimulation in chronic post-stroke aphasia. +"34",34,"High Definition Transcranial Alternating Current Stimulation (HD-tACS) for Post-stroke Aphasia","Transcranial Alternating Current Stimulation Post-stroke Aphasia Functional Magnetic Resonance Imaging","March 18, 2021","NCT05502822","Anhui Medical University Hefei NA China","Anhui Medical University","Recruiting","To investigate the intervention effect of high definition transcranial alternating current stimulation(HD-tACS) in chronic post-stroke aphasia and its underlying neural mechanism by MRI.","Aphasia is one of the most frequent cognitive deficits in poststroke survivor. More than 20% of stroke patients suffered from language impairment. The recovery of language dysfunction after stroke is highly variable. Some patients recover spontaneously in the early phases of stroke, but about two thirds of patients never fully restore language ability. The purpose of this study was to explore the intervention effect of high definition transcranial alternating current stimulation in chronic post-stroke aphasia. 40 patients with language disorder diagnosed by the Aphasia Battery of Chinese (ABC) were recruited from the first affiliated Hospital of Anhui Medical University. All participants underwent a structured interview and routine laboratory examination before and after receiving HD-tACS. After meeting the inclusion criteria and obtaining informed consent, each participant will complete the clinical evaluation, functional magnetic resonance imaging (fMRI) and HD-tACS treatment conducted by trained researchers at the Neuropsychological Synergetic Innovation Center of Anhui Medical University. @@ -833,7 +814,7 @@ severe dysarthria. a history of head injury or surgery. alcohol or substance abuse. cerebral tumor or abscess.","No","18 Years","All","Hefei",NA,NA,"WANG KAI","China",1,"no",117.349720247305,31.0729498560408,2021-03-18 -"36",36,"Improving Aphasia Using Electrical Brain Stimulation","Stroke Aphasia","July 12, 2021","NCT04963803","Syracuse University Syracuse New York United States","Syracuse University","Recruiting","Language and communication are essential for almost every aspect of human life, but for people who have aphasia, a language processing disorder that can occur after stroke or brain injury, even simple conversations can become a formidable challenge. Speech and language therapy can help people recover their language ability, but often requires months or even years of therapy before a person is able to overcome these challenges. This research will investigate non-invasive brain stimulation as a way to enhance the effects of speech and language therapy, which may ultimately lead to better and faster recovery from stroke and aphasia. The investigators hypothesize that participants with aphasia who receive speech and language therapy paired with active electrical brain stimulation will improve significantly more on a language comprehension task than those who receive speech and language therapy paired with sham stimulation.",NA,"tDCS attention language speech-language therapy","Interventional","Inclusion Criteria: +"35",35,"Improving Aphasia Using Electrical Brain Stimulation","Stroke Aphasia","July 12, 2021","NCT04963803","Syracuse University Syracuse New York United States","Syracuse University","Recruiting","Language and communication are essential for almost every aspect of human life, but for people who have aphasia, a language processing disorder that can occur after stroke or brain injury, even simple conversations can become a formidable challenge. Speech and language therapy can help people recover their language ability, but often requires months or even years of therapy before a person is able to overcome these challenges. This research will investigate non-invasive brain stimulation as a way to enhance the effects of speech and language therapy, which may ultimately lead to better and faster recovery from stroke and aphasia. The investigators hypothesize that participants with aphasia who receive speech and language therapy paired with active electrical brain stimulation will improve significantly more on a language comprehension task than those who receive speech and language therapy paired with sham stimulation.",NA,"tDCS attention language speech-language therapy","Interventional","Inclusion Criteria: 18 years or older. No diagnosis of neurological disorder (other than stroke). @@ -868,7 +849,7 @@ No aphasia or severe aphasia. Cognitive ability below functional limits. Unable to pass vision and/or hearing screening with use of corrective aids. Unwilling to allow audio-recording of study sessions.","No","18 Years","All","Syracuse","13244","New York",NA,"United States",1,"no",-76.1713255,43.0215885,2021-07-12 -"37",38,"Speeded Anomia Treatment in Chronic Post-stroke Aphasia","Aphasia","January 15, 2023","NCT05512884","University of Cambridge Cambridge NA United Kingdom","University of Cambridge","Recruiting","The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord).","The main aim is to test the clinical efficacy of a novel, web based, rehabilitation approach to aphasic word-finding difficulties (QuickWord). In an initial development and case-series evaluation, Conroy et al (2018, Brain) found that training for both speed as well as accuracy of naming generated much better outcomes to picture naming accuracy and also augmented the carry-over to connected speech production. +"36",37,"Speeded Anomia Treatment in Chronic Post-stroke Aphasia","Aphasia","January 15, 2023","NCT05512884","University of Cambridge Cambridge NA United Kingdom","University of Cambridge","Recruiting","The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord).","The main aim is to test the clinical efficacy of a novel, web based, rehabilitation approach to aphasic word-finding difficulties (QuickWord). In an initial development and case-series evaluation, Conroy et al (2018, Brain) found that training for both speed as well as accuracy of naming generated much better outcomes to picture naming accuracy and also augmented the carry-over to connected speech production. This is a randomised, crossover, clinical trial of QuickWord in a group of aphasic patients in the chronic post-stroke period. The comparison will be standard care. The main outcome measures are clinically relevant improvement in naming to confrontation, and spontaneous use of the target vocabulary in a connected speech sample (detailed picture description). Secondary outcome includes measured use of the vocabulary in a story-telling, connected speech assessment (retelling of the Cinderella story).","Anomia Speech Disorders Language Disorders Communication Disorders","Interventional","Inclusion Criteria: @@ -893,7 +874,7 @@ Unable to give informed consent Currently receiving Speech & Language therapy Insufficient repetition skills (<40% on an immediate word repetition test) Good naming performance (>90% in Boston Naming Test - Goodglass et al., 1983)","No","18 Years","All","Cambridge","CB2 7EF",NA,"Matthew A. Lambon Ralph","United Kingdom",1,"no",0.1216705,52.202776,2023-01-15 -"38",39,"Timing of Transcranial Direct Current Stimulation (tDCS) Combined With Speech and Language Therapy (SLT)","Aphasia","April 3, 2019","NCT03773406","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","Aphasia is an acquired (typically left-hemisphere) multi-modality disturbance of language that impacts around 2 million people in the USA. Aphasia impacts language production and comprehension as well as reading and writing. The ramifications of aphasia extend beyond language impairment to negatively impacting a person's social, vocational, and recreational activities. Currently, the most effective way to treat aphasia is with speech-language therapy (SLT). However, even if SLT is intensive, persons with aphasia are left with residual language delays. Recent research suggests that pairing SLT with transcranial direct current stimulation (tDCS) a non-invasive, safe, low-cost form of brain stimulation may aid language recovery in persons with aphasia. However, results from tDCS studies are inconclusive. The success of tDCS in combination with SLT could depend on the timing of tDCS since tDCS-induced effects depend on the neuronal state of the brain-networks at the time of the stimulation. In this study, the differential impact of tDCS before behavioral SLT (offline-before therapy), tDCS after SLT (offline-after therapy), and tDCS concurrently with SLT (online) on functional language recovery in persons with aphasia will be investigated. Sham tDCS (i.e., SLT alone) as a control group will also be included in the study. The investigators hypothesize that both offline and online tDCS will improve language functioning than sham tDCS.","tDCS Implementation: +"37",38,"Timing of Transcranial Direct Current Stimulation (tDCS) Combined With Speech and Language Therapy (SLT)","Aphasia","April 3, 2019","NCT03773406","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","Aphasia is an acquired (typically left-hemisphere) multi-modality disturbance of language that impacts around 2 million people in the USA. Aphasia impacts language production and comprehension as well as reading and writing. The ramifications of aphasia extend beyond language impairment to negatively impacting a person's social, vocational, and recreational activities. Currently, the most effective way to treat aphasia is with speech-language therapy (SLT). However, even if SLT is intensive, persons with aphasia are left with residual language delays. Recent research suggests that pairing SLT with transcranial direct current stimulation (tDCS) a non-invasive, safe, low-cost form of brain stimulation may aid language recovery in persons with aphasia. However, results from tDCS studies are inconclusive. The success of tDCS in combination with SLT could depend on the timing of tDCS since tDCS-induced effects depend on the neuronal state of the brain-networks at the time of the stimulation. In this study, the differential impact of tDCS before behavioral SLT (offline-before therapy), tDCS after SLT (offline-after therapy), and tDCS concurrently with SLT (online) on functional language recovery in persons with aphasia will be investigated. Sham tDCS (i.e., SLT alone) as a control group will also be included in the study. The investigators hypothesize that both offline and online tDCS will improve language functioning than sham tDCS.","tDCS Implementation: 2mA of direct current for 20 minutes will be delivered using a constant current stimulator via two electrodes in saline soaked sponges. To stimulate the left angular gyrus, a cathodal electrode inside a saline soaked sponge (5 x 3cm) will be placed over the CP5 according to the 10-20 international system for EEG electrode placement. The electrodes will be secured in position by a custom-built EEG cap that will be marked with the location for angular gyrus. The investigators will then confirm that the cathodal electrode is over the left angular through the use of neuronavigation. The ""return"" anode electrode will be placed in a saline soaked sponge (5 x 5cm) on the center of the supraorbital region. @@ -922,7 +903,7 @@ Exclusion Criteria: Any other neurological condition (other than cerebral vascular disease) that could impact language and cognition such as Alzheimer's disease, Parkinson's disease, primary progressive aphasia, and traumatic brain injury Active substance use Individuals with epilepsy","No","18 Years","All","Chicago","60611","Illinois","Leora Cherney","United States",1,"no",-87.618428,41.893889,2019-04-03 -"39",44,"Speech Entrainment Treatment for People With Aphasia","Aphasia, Acquired","January 25, 2023","NCT05687994","Albert Einstein Healthcare Network Elkins Park Pennsylvania United States","Albert Einstein Healthcare Network","Recruiting","The objective of this research is to experimentally delineate the direct effect of speech entrainment practice on independent speech production and identify practice conditions that enhance treatment benefits. The primary outcome measure (Correct Information Units per minute) tallies informativeness and efficiency of independent speech in treated stories.","Speech entrainment refers to speaking in unison with a model speaker by imitating the model in real time. The objective of the study is to (1) experimentally establish the direct effect of speech entrainment practice on independent speech production post-treatment, and (2) identify conditions that enhance treatment benefits. These aims are addressed in a within-subject efficacy study, where 40 people with aphasia produce different stories with entrainment support. Speaking without entrainment is evaluated one day before and one day after speech entrainment practice. Different practice stories will be randomized within participants to three experimental conditions to assess the effect of treatment (trained vs. untrained), training schedule (massed vs. distributed presentation of stories), and entrainment modality (practice with auditory-only or audiovisual model). Correct information units per minute for each story will be tallied to evaluate the differences between conditions and the associations with patient characteristics. For consistency with prior research, number of different words per minute will serve as a secondary outcome. The proposed research addresses a clinical need by testing and optimizing a promising treatment technique for enhancing aphasia rehabilitation. +"38",43,"Speech Entrainment Treatment for People With Aphasia","Aphasia, Acquired","January 25, 2023","NCT05687994","Albert Einstein Healthcare Network Elkins Park Pennsylvania United States","Albert Einstein Healthcare Network","Recruiting","The objective of this research is to experimentally delineate the direct effect of speech entrainment practice on independent speech production and identify practice conditions that enhance treatment benefits. The primary outcome measure (Correct Information Units per minute) tallies informativeness and efficiency of independent speech in treated stories.","Speech entrainment refers to speaking in unison with a model speaker by imitating the model in real time. The objective of the study is to (1) experimentally establish the direct effect of speech entrainment practice on independent speech production post-treatment, and (2) identify conditions that enhance treatment benefits. These aims are addressed in a within-subject efficacy study, where 40 people with aphasia produce different stories with entrainment support. Speaking without entrainment is evaluated one day before and one day after speech entrainment practice. Different practice stories will be randomized within participants to three experimental conditions to assess the effect of treatment (trained vs. untrained), training schedule (massed vs. distributed presentation of stories), and entrainment modality (practice with auditory-only or audiovisual model). Correct information units per minute for each story will be tallied to evaluate the differences between conditions and the associations with patient characteristics. For consistency with prior research, number of different words per minute will serve as a secondary outcome. The proposed research addresses a clinical need by testing and optimizing a promising treatment technique for enhancing aphasia rehabilitation. This proof-of-concept study is the first to evaluate the direct effect of speech entrainment practice on independent speech. Thus, the effect size for accurate power estimation is not known. The strategy for this study is to optimize experimental sensitivity by maximizing the number of observations per participants per condition within the constraints of feasibility. The results from this study will provide critical information for evaluating the effect size for a subsequent phase. Nevertheless, to estimate an optimal sample size, the investigators leveraged the data from our Pilot Study, which examines the speech entrainment effect on immediate performance rather than learning. With 13 participants, the investigators estimated 80% power to detect the effect of 0.8 (mean difference between groups divided by the pooled standard deviation) observed in our pilot study for speaking with audiovisual speech entrainment vs. independent speech (Aim 1). The calculation is based on a paired t-test with an alpha of .05 (two-tailed) and a correlation of 0.5 between groups. With 24 participants, there is 80% power to detect the observed effect of 0.6 for speaking with audiovisual speech entrainment vs. auditory-only speech entrainment (alpha is set to .05, two-tailed, correlation between groups is .57; Aim 2b). The investigators have substantially increased the sample size (N=40) with the consideration that learning effects (the focus of the present study) are expected to be smaller than performance effects (the focus of the Pilot Study).","","Interventional","Inclusion Criteria: @@ -937,7 +918,7 @@ Exclusion Criteria: History of learning disabilities History of other comorbid neurological impairments","No","18 Years","All","Elkins Park","19027","Pennsylvania","Marja-Liisa Mailend, PhD","United States",1,"no",-75.120418,40.035597,2023-01-25 -"40",47,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Bron Cedex NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. +"39",46,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Bron Cedex NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. The aim of this study is to show that a motor training with a tool (pliers) can improve short-term and long-term language abilities of aphasic patients who had a stroke at least 3 months ago. @@ -976,7 +957,7 @@ Recurrence of a stroke impacting the reorganisation of neural networks Persons deprived of their liberty by a judicial or administrative decision Persons of legal age under a legal protection measure (guardianship, curatorship) Pregnant women, women in labour or nursing mothers, confirmed by questioning the participant Participation in another study at the same time as this one","Accepts Healthy Volunteers","18 Years","All","Bron Cedex","69500",NA,NA,"France",1,"no",4.83742,45.759372,2023-05-26 -"41",47,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Bron NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. +"40",46,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Bron NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. The aim of this study is to show that a motor training with a tool (pliers) can improve short-term and long-term language abilities of aphasic patients who had a stroke at least 3 months ago. @@ -1015,7 +996,7 @@ Recurrence of a stroke impacting the reorganisation of neural networks Persons deprived of their liberty by a judicial or administrative decision Persons of legal age under a legal protection measure (guardianship, curatorship) Pregnant women, women in labour or nursing mothers, confirmed by questioning the participant Participation in another study at the same time as this one","Accepts Healthy Volunteers","18 Years","All","Bron","69500",NA,NA,"France",1,"no",4.83742,45.759372,2023-05-26 -"42",47,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Saint-Genis-Laval NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. +"41",46,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Saint-Genis-Laval NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. The aim of this study is to show that a motor training with a tool (pliers) can improve short-term and long-term language abilities of aphasic patients who had a stroke at least 3 months ago. @@ -1054,7 +1035,7 @@ Recurrence of a stroke impacting the reorganisation of neural networks Persons deprived of their liberty by a judicial or administrative decision Persons of legal age under a legal protection measure (guardianship, curatorship) Pregnant women, women in labour or nursing mothers, confirmed by questioning the participant Participation in another study at the same time as this one","Accepts Healthy Volunteers","18 Years","All","Saint-Genis-Laval","69230",NA,NA,"France",1,"no",4.792883,45.695002,2023-05-26 -"43",48,"Combining tDCS and CILT in Non-fluent Aphasia","Aphasia Non-fluent Aphasia Stroke Brain Injuries","April 24, 2023","NCT05561400","University of Minnesota Duluth Minnesota United States","University of Minnesota","Recruiting","The long-term goal of this work is to determine if combining a highly intensive, task-specific behavioral language intervention with modulation of the efferent cerebellar-cortical pathway using transcranial direct current stimulation (tDCS) has a positive influence on discourse, verbal fluency and working memory in individuals with non-fluent aphasia after stroke. And if these changes can be related to neuroplastic change in the cerebellar cortical pathway indirectly measured through neurophysiologic changes using spectral electroencephalogram (EEG). The initial phase includes the proposed pilot study data from which will be used to inform a larger clinical trial. The primary aims of this pilot are to 1) determine the effect of combining cerebellar tDCS with constraint-induced language therapy (CILT) on language as measured by a verbal fluency task and discourse task in a small population and 2) identify the tolerance of the intervention and barriers to participation measured by the adverse events questionnaire that will inform the methodology of a larger study. The secondary aims include estimating the size of the treatment effect on 1) delta percentage in F3, F7 and Fp1 compared to F4, F8, and Fp2 using resting state EEG spectral analysis and coherence, 2) working memory as measured by the score on the n-back test and 3) quality of life as measured by the Stroke Aphasia Quality of Life survey tool. The secondary aims will be used to determine the utility of these measures in a larger clinical trial. +"42",47,"Combining tDCS and CILT in Non-fluent Aphasia","Aphasia Non-fluent Aphasia Stroke Brain Injuries","April 24, 2023","NCT05561400","University of Minnesota Duluth Minnesota United States","University of Minnesota","Recruiting","The long-term goal of this work is to determine if combining a highly intensive, task-specific behavioral language intervention with modulation of the efferent cerebellar-cortical pathway using transcranial direct current stimulation (tDCS) has a positive influence on discourse, verbal fluency and working memory in individuals with non-fluent aphasia after stroke. And if these changes can be related to neuroplastic change in the cerebellar cortical pathway indirectly measured through neurophysiologic changes using spectral electroencephalogram (EEG). The initial phase includes the proposed pilot study data from which will be used to inform a larger clinical trial. The primary aims of this pilot are to 1) determine the effect of combining cerebellar tDCS with constraint-induced language therapy (CILT) on language as measured by a verbal fluency task and discourse task in a small population and 2) identify the tolerance of the intervention and barriers to participation measured by the adverse events questionnaire that will inform the methodology of a larger study. The secondary aims include estimating the size of the treatment effect on 1) delta percentage in F3, F7 and Fp1 compared to F4, F8, and Fp2 using resting state EEG spectral analysis and coherence, 2) working memory as measured by the score on the n-back test and 3) quality of life as measured by the Stroke Aphasia Quality of Life survey tool. The secondary aims will be used to determine the utility of these measures in a larger clinical trial. This is a prospective, crossover study, sham-controlled intervention study with two intervention conditions delivered across 6 intervention sessions (3x/week for two weeks) with a 4-week washout in between. Conditions include: 1) sham cerebellar tDCS and 2) real cerebellar tDCS delivered at 2mA across 20 minutes. Each of these will be delivered during CILT intervention with a licensed, certified speech-language pathologist trained in CILT. Once tDCS stimulation has ended, CILT will continue to be delivered for an additional 25 minutes. Assessments of discourse, verbal fluency, working memory and EEG spectral analysis will be conducted at four timepoints, before and after each intervention phase.","This is a prospective sham-controlled, cross-over design. Eligible participants must be over the age of 18 years, be > least 6 months post unilateral cortical stroke and diagnosed with mild to moderate non-fluent aphasia. Additional inclusion/exclusionary criteria have been specified in and approved by the IRB. Six to seven participants are expected to be recruited and screened, with the goal to enroll and complete the study with four individuals who will be randomly assigned to receive either sham or real condition first. The two intervention conditions include: 1) andodal tDCS (2mA) to the right posterior-lateral cerebellum and 2) sham tDCS to the right posterior-lateral cerebellum. The participants will receive 20 minutes of tDCS (sham or real) during CILT followed by an additional 25 minutes of CILT alone. Each condition will be administered 3 days per week for two weeks for a total of 6 intervention sessions with a 4-week washout period between. @@ -1077,7 +1058,7 @@ history of migraines, psoriasis or eczema affecting the scalp, history of a head injury such as a concussion diagnosis of a mental health or neurological condition/disease.","No","18 Years","All","Duluth","55812","Minnesota",NA,"United States",1,"no",-92.08343,46.8190805,2023-04-24 -"44",49,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"43",48,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1100,7 +1081,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Baltimore","21287","Maryland",NA,"United States",1,"no",-76.6204945,39.3289375,2021-07-18 -"45",49,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Charleston South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"44",48,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Charleston South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1123,7 +1104,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Charleston","29425","South Carolina",NA,"United States",1,"no",-80.10815,32.792398,2021-07-18 -"46",49,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Columbia South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"45",48,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Columbia South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1146,7 +1127,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Columbia","29208","South Carolina",NA,"United States",1,"no",-81.034331,34.000749,2021-07-18 -"47",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Aachen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"46",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Aachen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1171,7 +1152,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Aachen","52074",NA,NA,"Germany",1,"no",6.083862,50.776351,2019-12-06 -"48",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Allensbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"47",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Allensbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1196,7 +1177,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Allensbach","78476",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"49",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Aibling NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"48",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Aibling NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1221,7 +1202,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Aibling","83209",NA,NA,"Germany",1,"no",12.009768,47.86405,2019-12-06 -"50",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Homburg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"49",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Homburg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1246,7 +1227,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Homburg","61348",NA,NA,"Germany",1,"no",8.618313,50.228032,2019-12-06 -"51",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Klosterlausnitz NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"50",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Klosterlausnitz NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1271,7 +1252,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Klosterlausnitz","07639",NA,NA,"Germany",1,"no",11.86817,50.916262,2019-12-06 -"52",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Sülze NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"51",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Sülze NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1296,7 +1277,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Sülze","18334",NA,NA,"Germany",1,"no",12.658113,54.111965,2019-12-06 -"53",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Berlin NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"52",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Berlin NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1321,7 +1302,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Berlin","10115",NA,NA,"Germany",1,"no",13.3888599,52.5170365,2019-12-06 -"54",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Gailingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"53",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Gailingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1346,7 +1327,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Gailingen","78262",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"55",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"54",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1371,7 +1352,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Greifswald","17475",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"56",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"55",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1396,7 +1377,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Greifswald","17491",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"57",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Göppingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"56",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Göppingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1421,7 +1402,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Göppingen","73035",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"58",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Heidelberg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"57",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Heidelberg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1446,7 +1427,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Heidelberg","69117",NA,NA,"Germany",1,"no",8.7112746,49.4121677,2019-12-06 -"59",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Kempen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"58",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Kempen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1471,7 +1452,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Kempen","47906",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"60",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Leipzig NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"59",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Leipzig NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1496,7 +1477,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Leipzig","04103",NA,NA,"Germany",1,"no",12.374733,51.340632,2019-12-06 -"61",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Lindlar NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"60",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Lindlar NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1521,7 +1502,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Lindlar","51789",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"62",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Marbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"61",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Marbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1546,7 +1527,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Marbach","71672",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"63",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Meerbusch NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"62",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Meerbusch NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1571,7 +1552,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Meerbusch","40670",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"64",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Vechta NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"63",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Vechta NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1596,7 +1577,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Vechta","49377",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"65",56,"Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia","Aphasia Apraxia of Speech","December 4, 2018","NCT05248295","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech are most helpful. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? A possible mechanism for this benefit is examined, by testing whether the degree of alignment of a person's speech with that of another speaker can account for unison benefit.","Aphasia is an acquired language disorder, most commonly due to stroke. It can affect an individual's ability to speak, understand spoken language, read, and write. Many treatments designed to improve spoken language in persons with aphasia (PWAs) use unison speech, having the person with aphasia speak along with the clinician or with a recording. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech help them the most. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? This knowledge is important because understanding who benefits from this commonly used and potentially powerful therapy component, under which conditions they benefit, and why they do, is critical for customizing therapy so it can be as effective and efficient as possible. Unison speech is conducted using one of two different timing patterns: (1) a natural conversational pattern, which is used in everyday conversations, or (2) a metrical pattern, which follows a beat-based timing framework, as in songs or some poems. In either case, precisely aligning one's speech with that of another person (i.e., entraining one's speech) requires prediction: each speaker must plan their own speech motor commands before having heard the other speaker say the words they are planning. Natural conversational timing requires the speaker to make use of knowledge about language, particularly grammar, to align with the other person. In contrast, a metrical pattern allows a speaker to predict speech timing without relying heavily on language-based knowledge. Given that many PWAs have impaired grammar, we hypothesize that most PWAs will benefit more from speaking in unison to sentences with metrical vs. conversational timing patterns. However, there is great variation in linguistic, motor speech, and timing skills across PWAs, so metrical and conversational timing patterns are likely to have different degrees of effectiveness for different individuals. Results from this study will demonstrate how individual characteristics and speech timing affect whether or not a person with aphasia benefits from speaking in unison. Results will also indicate whether a speaker's ability to predict speech timing is necessary for a benefit of unison speech. Prediction ability will be measured by how closely the speaker aligns their speech with a spoken model.","","Interventional","Inclusion Criteria: +"64",55,"Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia","Aphasia Apraxia of Speech","December 4, 2018","NCT05248295","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech are most helpful. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? A possible mechanism for this benefit is examined, by testing whether the degree of alignment of a person's speech with that of another speaker can account for unison benefit.","Aphasia is an acquired language disorder, most commonly due to stroke. It can affect an individual's ability to speak, understand spoken language, read, and write. Many treatments designed to improve spoken language in persons with aphasia (PWAs) use unison speech, having the person with aphasia speak along with the clinician or with a recording. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech help them the most. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? This knowledge is important because understanding who benefits from this commonly used and potentially powerful therapy component, under which conditions they benefit, and why they do, is critical for customizing therapy so it can be as effective and efficient as possible. Unison speech is conducted using one of two different timing patterns: (1) a natural conversational pattern, which is used in everyday conversations, or (2) a metrical pattern, which follows a beat-based timing framework, as in songs or some poems. In either case, precisely aligning one's speech with that of another person (i.e., entraining one's speech) requires prediction: each speaker must plan their own speech motor commands before having heard the other speaker say the words they are planning. Natural conversational timing requires the speaker to make use of knowledge about language, particularly grammar, to align with the other person. In contrast, a metrical pattern allows a speaker to predict speech timing without relying heavily on language-based knowledge. Given that many PWAs have impaired grammar, we hypothesize that most PWAs will benefit more from speaking in unison to sentences with metrical vs. conversational timing patterns. However, there is great variation in linguistic, motor speech, and timing skills across PWAs, so metrical and conversational timing patterns are likely to have different degrees of effectiveness for different individuals. Results from this study will demonstrate how individual characteristics and speech timing affect whether or not a person with aphasia benefits from speaking in unison. Results will also indicate whether a speaker's ability to predict speech timing is necessary for a benefit of unison speech. Prediction ability will be measured by how closely the speaker aligns their speech with a spoken model.","","Interventional","Inclusion Criteria: Native-speaker fluency in American English (prior to stroke for people with aphasia) Controls must report no history of speech, language, neurological disorders, or stroke @@ -1608,7 +1589,7 @@ Inadequate hearing ability to reliably complete task: fail hearing screen Inadequate cognitive ability to understand and remember task: fail cognition screening (different measures for controls and people with aphasia) Inadequate speech repetition ability to complete task, or to be considered a control: fail speech repetition screening (different thresholds for controls and people with aphasia) Inadequate auditory comprehension ability to understand task: fail auditory comprehension screen (people with aphasia only)","Accepts Healthy Volunteers","18 Years","All","Boston","02129","Massachusetts","Lauryn Zipse, Ph.D., CCC-SLP","United States",1,"no",-71.0537615,42.3756115,2018-12-04 -"66",58,"Individualized Precision rTMS for Language Recovery in Patients After Ischemic Stroke: a Multi-center RCT","Stroke, Ischemic Aphasia","June 5, 2023","NCT05842304","Changping Laboratory Beijing NA China","Changping Laboratory","Recruiting","The current multi-center study aims to evaluate the efficacy and safety of pBFS-guided rTMS Neuromodulation Treatment for the rehabilitation of language functions in ischemic stroke aphasic patients.","Increasing evidence suggests that rTMS has been effective in treating various psychological and neurological diseases, including treating post-stroke symptoms. Using the personalized brain functional sectors (pBFS) technique, we could precisely identify individualized brain functional networks and the personalized language-related stimulation site based on the resting-state functional MRI data. The current study proposes to conduct a multi-center, double-blinded, randomized and parallel controlled design trial, to investigate the efficacy and safety of pBFS-guided personalized TMS intervention in post-stroke aphasic patients. +"65",57,"Individualized Precision rTMS for Language Recovery in Patients After Ischemic Stroke: a Multi-center RCT","Stroke, Ischemic Aphasia","June 5, 2023","NCT05842304","Changping Laboratory Beijing NA China","Changping Laboratory","Recruiting","The current multi-center study aims to evaluate the efficacy and safety of pBFS-guided rTMS Neuromodulation Treatment for the rehabilitation of language functions in ischemic stroke aphasic patients.","Increasing evidence suggests that rTMS has been effective in treating various psychological and neurological diseases, including treating post-stroke symptoms. Using the personalized brain functional sectors (pBFS) technique, we could precisely identify individualized brain functional networks and the personalized language-related stimulation site based on the resting-state functional MRI data. The current study proposes to conduct a multi-center, double-blinded, randomized and parallel controlled design trial, to investigate the efficacy and safety of pBFS-guided personalized TMS intervention in post-stroke aphasic patients. Subjects will be randomly assigned to the following two groups: active continuous TBS (cTBS) group, or a sham control group. The allocation ratio will be 2:1. Subjects will receive a 3-week treatment for 21 consecutive days. The stimulation procedure will be assisted with real-time neuronavigation to ensure its precision.","","Interventional","Inclusion Criteria: @@ -1637,7 +1618,7 @@ History of alcohol, drug, and/or other abuse. Patients with other test abnormalities judged by the investigator to be unsuitable for the trial. Women of childbearing age who are pregnant or preparing for pregnancy. Patients who are participating in other clinical research trials.","No","35 Years","All","Beijing",NA,NA,NA,"China",1,"no",116.225091,40.219646,2023-06-05 -"67",61,"Treatment Outcomes With tDCS in Post-Stroke Aphasia","Aphasia","September 3, 2019","NCT03929432","University of Arkansas Little Rock Arkansas United States","University of Arkansas","Recruiting","The purpose this study is to test the utility of pairing external neuromodulation with behavioral language treatment to boost therapy outcomes and to investigate the mechanisms associated with recovery. Because all PWA have word retrieval deficits, this project will test if greater language gains can be achieved by supplementing anomia intervention with excitatory brain stimulation to the left hemisphere and will evaluate associated functional brain changes to aid the optimization of neural reorganization to facilitate language processing.","Aphasia is a language impairment that commonly occurs following brain damage (e.g., stroke). While language rehabilitation can yield improved language functioning, treatment outcomes vary greatly across individuals. In chronic aphasia, language gains occur through the brain's inherent ability to reorganize (i.e., neuroplasticity). +"66",60,"Treatment Outcomes With tDCS in Post-Stroke Aphasia","Aphasia","September 3, 2019","NCT03929432","University of Arkansas Little Rock Arkansas United States","University of Arkansas","Recruiting","The purpose this study is to test the utility of pairing external neuromodulation with behavioral language treatment to boost therapy outcomes and to investigate the mechanisms associated with recovery. Because all PWA have word retrieval deficits, this project will test if greater language gains can be achieved by supplementing anomia intervention with excitatory brain stimulation to the left hemisphere and will evaluate associated functional brain changes to aid the optimization of neural reorganization to facilitate language processing.","Aphasia is a language impairment that commonly occurs following brain damage (e.g., stroke). While language rehabilitation can yield improved language functioning, treatment outcomes vary greatly across individuals. In chronic aphasia, language gains occur through the brain's inherent ability to reorganize (i.e., neuroplasticity). While Speech-language therapy (SLT) can target various language skills and modalities, the most pervasive deficit across all persons with aphasia (PWA) is difficulty with word finding. Thus, aphasia treatment often includes some form of intervention focused on improving naming abilities. As with language function in general, naming abilities in PWA seems to be associated with left hemisphere recruitment, particularly with the viable tissue at the rim of the lesion (perilesional areas). This project investigates an innovative approach to improving current therapy by examining the benefits of using excitatory transcranial direct current stimulation (tDCS) stimulation/neuromodulation during anomia treatment (i.e. word-finding treatment). @@ -1664,7 +1645,7 @@ Co-occurring history of neurological disease/disorder/injury (e.g., traumatic br Co-occurring history of a major mental illness (e.g., schizophrenia, drug addiction, bipolar) Clinical conditions contraindicated for MRI or tDCS (e.g., implanted electrical devices, claustrophobia, seizure disorder) Positive pregnancy test (for females)","No","18 Years","All","Little Rock","72205","Arkansas",NA,"United States",1,"no",-92.3396525,34.7224165,2019-09-03 -"68",72,"Transcranial Alternating Current Stimulation (tACS) in Aphasia","Aphasia Stroke","January 4, 2020","NCT04375722","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States (NIH-NIDCD, 2015). Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits by providing brain stimulation concurrent with therapies. Transcranial direct current stimulation (tDCS) is one of the most widely used such technique. While tDCS has had relative success in chronic aphasia (>6 months after stroke), it has not been efficacious during subacute stages (<3 months after stroke). But enhancing language recovery early after stroke is desirable because of its potential impact on long-term language outcomes and quality-of-life. +"67",72,"Transcranial Alternating Current Stimulation (tACS) in Aphasia","Aphasia Stroke","January 4, 2020","NCT04375722","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States (NIH-NIDCD, 2015). Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits by providing brain stimulation concurrent with therapies. Transcranial direct current stimulation (tDCS) is one of the most widely used such technique. While tDCS has had relative success in chronic aphasia (>6 months after stroke), it has not been efficacious during subacute stages (<3 months after stroke). But enhancing language recovery early after stroke is desirable because of its potential impact on long-term language outcomes and quality-of-life. The current study will investigate the efficacy of high-definition tACS (HD-tACS) to help restore neural oscillatory activity in aphasia. TACS differs from tDCS in that sinusoidal, alternating currents are delivered rather than constant currents. TACS can manipulate the ongoing oscillatory neuronal activity and potentially increase functional synchronization (or connectivity) between targeted areas. This feature of tACS is quite attractive, given the new body of evidence suggesting that language impairments stem from diminished functional connectivity and disruptions in the language network due to stroke. The selection of tACS frequencies in this study is guided by our preliminary work examining pathological neural oscillations found near stroke-lesioned areas (or perilesional) in aphasia. By exogenously tuning the perilesional oscillations with tACS, the investigators hope to up-regulate communication across these areas and other connected areas to improve language outcome. If successful, tACS will be a powerful and novel treatment approach with reverberating positive impact on long-term recovery. @@ -1696,7 +1677,7 @@ Any metal implants in the skull Contraindications to MRI or tACS History of seizures History of dyslexia or other developmental learning disabilities","Accepts Healthy Volunteers","18 Years","All","Milwaukee","53226","Wisconsin","Priyanka Shah-Basak, PhD","United States",1,"no",-88.022002,43.04338,2020-01-04 -"69",77,"Treatment of Grammatical Time Marking in Post-Stroke Aphasia","Brain Injury, Vascular Aphasia Stroke","December 30, 2022","NCT05656638","University of Neuchatel Neuchâtel NA Switzerland","University of Neuchatel","Recruiting","The study aims to assess a individual or group therapy's effectiveness in grammatical time marking. The main objective is to examine whether the therapy improves grammatical time marking of inflected verbs treated on the sessions. We also explore whether the observed progress can be transferred to untrained items, more ecological contexts and if is maintained two and four weeks after the end of treatment. +"68",77,"Treatment of Grammatical Time Marking in Post-Stroke Aphasia","Brain Injury, Vascular Aphasia Stroke","December 30, 2022","NCT05656638","University of Neuchatel Neuchâtel NA Switzerland","University of Neuchatel","Recruiting","The study aims to assess a individual or group therapy's effectiveness in grammatical time marking. The main objective is to examine whether the therapy improves grammatical time marking of inflected verbs treated on the sessions. We also explore whether the observed progress can be transferred to untrained items, more ecological contexts and if is maintained two and four weeks after the end of treatment. This therapy will be administered to nine individuals with brain lesions after stroke. Five individuals will take part of the individual therapy and four individuals will take part of the group therapy (two individuals per group). The therapy will last one month, at the rate of three weekly sessions of approximately one hour.",NA,"","Interventional","Inclusion Criteria: @@ -1713,7 +1694,7 @@ Have significant impairments in oral/written comprehension. Present apraxia of speech or a severe arthritic disorder Present hemineglect Present impaired judgment and discernment, objectified by a neuropsychological evaluation","No","18 Years","All","Neuchâtel","2000",NA,"Marion Fossard","Switzerland",1,"no",6.931074,46.993392,2022-12-30 -"70",80,"Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia","Stroke Aphasia Apraxia of Speech","July 22, 2020","NCT04816799","Arizona State University Tempe Arizona United States","Arizona State University","Recruiting","A stratified, parallel-group, double-blind, randomized controlled trial of remotely delivered START treatment to individuals with severe-to-moderate stroke (with recruitment focused on individuals with low SES) will be conducted. Subjects and assessors will be blinded to the condition making the experiment double blind. Specifically, subjects will be told that we are exploring a new therapy that using different sounds to improve therapy. Parallel group design will ensure that subjects in the Control group are unaware that their ""sounds"" are softer than the START group. Trainers may become aware that a loud sound is present thus a unique Assessor will evaluate clinical performance before and after training making the study double-blind. Fifty-four subjects will undergo baseline testing in the laboratory to establish their capacity for functional and expressive speech as well as their self-reported health-related quality of life (power analysis below). Next, subjects will participate in a high-frequency, word-picture verification/ auditory-repetition treatment, 2 hr/day for 5 consecutive days focusing on expression of words of functional significance (e.g., water, fall). Subjects will either receive training with START or without (Control). Subjects will be re-tested immediately following training as well as one-month post to assess retention. Aim 1 will evaluate capacity of START to enhance SLT outcomes by assessing the % change in clinical assessment of functional and expressive speech. Our preliminary data points to a robust response [details]. Aim 2 will focus on the capacity of these changes to 1) be retained and 2) impact subject's reported quality of life. NOTE: While we are planning in-person baseline, end, and retention testing, in response to COVID, we have established remote clinical screening using peer-reviewed validated techniques for WAB and ABA-2 (see Alternative Solutions). All preliminary data collected for this proposal were collected remotely via no-contact protocols.",NA,"","Interventional","Inclusion Criteria: +"69",80,"Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia","Stroke Aphasia Apraxia of Speech","July 22, 2020","NCT04816799","Arizona State University Tempe Arizona United States","Arizona State University","Recruiting","A stratified, parallel-group, double-blind, randomized controlled trial of remotely delivered START treatment to individuals with severe-to-moderate stroke (with recruitment focused on individuals with low SES) will be conducted. Subjects and assessors will be blinded to the condition making the experiment double blind. Specifically, subjects will be told that we are exploring a new therapy that using different sounds to improve therapy. Parallel group design will ensure that subjects in the Control group are unaware that their ""sounds"" are softer than the START group. Trainers may become aware that a loud sound is present thus a unique Assessor will evaluate clinical performance before and after training making the study double-blind. Fifty-four subjects will undergo baseline testing in the laboratory to establish their capacity for functional and expressive speech as well as their self-reported health-related quality of life (power analysis below). Next, subjects will participate in a high-frequency, word-picture verification/ auditory-repetition treatment, 2 hr/day for 5 consecutive days focusing on expression of words of functional significance (e.g., water, fall). Subjects will either receive training with START or without (Control). Subjects will be re-tested immediately following training as well as one-month post to assess retention. Aim 1 will evaluate capacity of START to enhance SLT outcomes by assessing the % change in clinical assessment of functional and expressive speech. Our preliminary data points to a robust response [details]. Aim 2 will focus on the capacity of these changes to 1) be retained and 2) impact subject's reported quality of life. NOTE: While we are planning in-person baseline, end, and retention testing, in response to COVID, we have established remote clinical screening using peer-reviewed validated techniques for WAB and ABA-2 (see Alternative Solutions). All preliminary data collected for this proposal were collected remotely via no-contact protocols.",NA,"","Interventional","Inclusion Criteria: 18 years old Native English Speakers @@ -1727,7 +1708,7 @@ Corrected pure tone threshold (octave frequencies 250- 4000 Hz) norms for their Exclusion Criteria: Severe concurrent uncontrolled medical problems (e.g. cardiorespiratory impairment).","No","18 Years","All","Tempe","85287","Arizona","Claire Honeycutt","United States",1,"no",-111.932727,33.416893,2020-07-22 -"71",83,"tDCS Effects on Brain Plasticity in Aphasia Treatment","Aphasia Stroke","November 1, 2021","NCT05483556","The Hong Kong Polytechnic University Kowloon NA Hong Kong","The Hong Kong Polytechnic University","Recruiting","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI. +"70",83,"tDCS Effects on Brain Plasticity in Aphasia Treatment","Aphasia Stroke","November 1, 2021","NCT05483556","The Hong Kong Polytechnic University Kowloon NA Hong Kong","The Hong Kong Polytechnic University","Recruiting","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI. This randomized, placebo-controlled, double-blinded pilot study will recruit ten chronic stroke patients with Broca's Aphasia randomly assigned either to sham or an anodal tDCS groups. Following speech and language assessment, all the participants will receive 20 minutes of individualized language therapy daily for ten days in two consecutive weeks. Simultaneously, the treatment group will receive 20 minutes of 2mA anodal HD-tDCS over the left IFG, while the sham group will receive the 30s of 2mA anodal HD-tDCS. Structural, resting state and task activated functional MRI will be performed. Data acquisition will be performed before, immediately after and two months after the treatment. @@ -1748,7 +1729,7 @@ Wernicke's aphasia and other speech disorders, degenerative, psychiatric or meta Deaf, blind, pregnant/ or preparing for pregnancy, cognitive issues, tattoos Have cochlear implants, pacemaker, surgical nails for bone fracture, artificial joints, dental braces, dentures Taking anti-depressant medications","No","18 Years","All","Kowloon",NA,NA,"Dr Min Wong","Hong Kong",1,"no",114.179821,22.3046025,2021-11-01 -"72",85,"Effects of Verb Network Strengthening Treatment (VNeST) on Word Finding in Aphasia","Anomia Aphasia Stroke","January 16, 2022","NCT05152979","Göteborg University Gothenburg Västra Götaland Sweden","Göteborg University","Recruiting","Although there is evidence that speech-language therapy may improve speech in language disorders following left hemisphere stroke there is still a lack of evidence for which types of therapy are effective. Furthermore, in Sweden, as well as in several other countries, access to speech-language therapy is limited. The purpose of this clinical trial is to compare outcome from Verb Network Strengthening Treatment (VNeST) provided as In-Clinic therapy (I-CT) or as synchronous telepractice therapy (TP-T).","Every year thousands of persons in Sweden suffer from brain damage resulting in anomia, that is, word finding difficulties affecting their ability to talk to other people. Anomia is one of the most common and persistent symptoms of aphasia following a left hemisphere stroke, but it is also common in in progressive neurological diseases such as Parkinson's disease or multiple sclerosis (MS). There is evidence that more intensive speech language therapy may improve speech even in a chronic (> six month post stroke) phase of aphasia. However, access to the necessary amount of speech language therapy is limited due to lack of financial resources as well as to limitations to service providers in more rural areas. +"71",85,"Effects of Verb Network Strengthening Treatment (VNeST) on Word Finding in Aphasia","Anomia Aphasia Stroke","January 16, 2022","NCT05152979","Göteborg University Gothenburg Västra Götaland Sweden","Göteborg University","Recruiting","Although there is evidence that speech-language therapy may improve speech in language disorders following left hemisphere stroke there is still a lack of evidence for which types of therapy are effective. Furthermore, in Sweden, as well as in several other countries, access to speech-language therapy is limited. The purpose of this clinical trial is to compare outcome from Verb Network Strengthening Treatment (VNeST) provided as In-Clinic therapy (I-CT) or as synchronous telepractice therapy (TP-T).","Every year thousands of persons in Sweden suffer from brain damage resulting in anomia, that is, word finding difficulties affecting their ability to talk to other people. Anomia is one of the most common and persistent symptoms of aphasia following a left hemisphere stroke, but it is also common in in progressive neurological diseases such as Parkinson's disease or multiple sclerosis (MS). There is evidence that more intensive speech language therapy may improve speech even in a chronic (> six month post stroke) phase of aphasia. However, access to the necessary amount of speech language therapy is limited due to lack of financial resources as well as to limitations to service providers in more rural areas. It has been suggested that telepractice may increase the access to speech-language therapy for more people but there is a lack of knowledge of whether there is a difference in outcome from interventions provided as In-Clinic therapy (I-CT) or as telepractice therapy (TP-T). @@ -1770,7 +1751,7 @@ Moderately or severely impaired comprehension Moderate-severe apraxia of speech or dysarthria which may interfere with assessment Participation in any other speech-language treatment during the study Active substance dependence","No","18 Years","All","Gothenburg","40530","Västra Götaland",NA,"Sweden",1,"no",11.961307,57.6970935,2022-01-16 -"73",86,"Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia","Aphasia Non Fluent Stroke","May 5, 2022","NCT04433351","University Hospital, Grenoble Grenoble NA France","University Hospital, Grenoble","Recruiting","SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that aims first, to test and develop a novel speech rehabilitation program designed for patients with non-fluent aphasia and, second, to better describe neural reorganization after successful recovery. To this end, the investigators will conduct a prospective monocentric cross-over study, including two cohorts of post-stroke aphasic patients and two control groups.","In this project, the investigators propose to evaluate the effectiveness of a new rehabilitation program, based on illustration of speech articulators, to improve speech in patients with non-fluent aphasia. The instigators' method is based on the reinforcement of the interaction between perceptual and motor representations, thanks to the innovative Ultraspeech device. The investigators will exploit a fundamental psycholinguistic principle, which postulates that speech is based both on the activation of the system controlling the motricity of effectors related to word articulation (action) and on the auditory or visual representation of words (perception). The sensory-motor interaction method that the investigators propose allows the patient to perceive phonemes and visualize on a computer screen the movements of the tongue and lips previously recorded by a healthy speaker, typically a speech therapist. Through repeated exercises, the patient is trained to produce sounds correctly, using the correct pronunciation and articulatory movements of the reference speaker as a model. The investigators will compare patients who will follow a classical speech and language therapy rehabilitation program followed by an 'enriched' rehabilitation program including rehabilitation based on sensory-motor interaction associated with speech and language therapy, and vice versa. In order to judge the favorable effect of the rehabilitation program including sensory-motor integration, the following measures will be considered: (a) language skills, (b) phonemic quality, (c) inner speech abilities and (d) cognitive function. Brain language networks will be evaluated with neuroimaging.","post-stroke aphasia non-fluent aphasia speech rehabilitation neuroimaging neural reorganization recovery","Interventional","Inclusion Criteria: +"72",86,"Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia","Aphasia Non Fluent Stroke","May 5, 2022","NCT04433351","University Hospital, Grenoble Grenoble NA France","University Hospital, Grenoble","Recruiting","SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that aims first, to test and develop a novel speech rehabilitation program designed for patients with non-fluent aphasia and, second, to better describe neural reorganization after successful recovery. To this end, the investigators will conduct a prospective monocentric cross-over study, including two cohorts of post-stroke aphasic patients and two control groups.","In this project, the investigators propose to evaluate the effectiveness of a new rehabilitation program, based on illustration of speech articulators, to improve speech in patients with non-fluent aphasia. The instigators' method is based on the reinforcement of the interaction between perceptual and motor representations, thanks to the innovative Ultraspeech device. The investigators will exploit a fundamental psycholinguistic principle, which postulates that speech is based both on the activation of the system controlling the motricity of effectors related to word articulation (action) and on the auditory or visual representation of words (perception). The sensory-motor interaction method that the investigators propose allows the patient to perceive phonemes and visualize on a computer screen the movements of the tongue and lips previously recorded by a healthy speaker, typically a speech therapist. Through repeated exercises, the patient is trained to produce sounds correctly, using the correct pronunciation and articulatory movements of the reference speaker as a model. The investigators will compare patients who will follow a classical speech and language therapy rehabilitation program followed by an 'enriched' rehabilitation program including rehabilitation based on sensory-motor interaction associated with speech and language therapy, and vice versa. In order to judge the favorable effect of the rehabilitation program including sensory-motor integration, the following measures will be considered: (a) language skills, (b) phonemic quality, (c) inner speech abilities and (d) cognitive function. Brain language networks will be evaluated with neuroimaging.","post-stroke aphasia non-fluent aphasia speech rehabilitation neuroimaging neural reorganization recovery","Interventional","Inclusion Criteria: patients with late sub-acute and chronic post-stroke (> 4 months) non-fluent aphasia after lesion in the dominant hemisphere for language native speakers of French @@ -1780,7 +1761,7 @@ satisfying all criteria for the MRI examination Exclusion Criteria: patients with comprehension deficits, hemi-spatial neglect or upper limb apraxia","No","55 Years","All","Grenoble","38043",NA,NA,"France",1,"no",5.735782,45.18756,2022-05-05 -"74",87,"Effects of Transcranial Direct Current Stimulation (tDCS) on Language","Stroke Aphasia","December 1, 2019","NCT04166513","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). +"73",87,"Effects of Transcranial Direct Current Stimulation (tDCS) on Language","Stroke Aphasia","December 1, 2019","NCT04166513","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). This study will examine the effects of tDCS during speech therapy to further examine which method or methods is best for patient recovery. Patients enrolled in the study will undergo language testing that covers a broad range of language functions. Functional Magnetic Resonance Imaging (fMRI) will be completed before and after speech therapy intervention arms to investigate the neural processes affected by tDCS and speech therapy. @@ -1798,7 +1779,7 @@ Advanced neurodegenerative disease (i.e. Stage 3 Alzheimer's disease) or neurolo Severe psychopathology (e.g. schizophrenia, bipolar disorder, acute major depressive episode) No suspected or diagnosed uncorrectable hearing or vision difficulties, or developmental disabilities (i.e. intellectual disability or learning disability). Contraindications to MRI such as claustrophobia, implanted electronic devices, MRI-incompatible metal in the body, extreme obesity, pregnancy, inability to lie flat, and inability to see or hear stimulus materials","No","18 Years","All","Milwaukee","53226","Wisconsin","Sara Pillay","United States",1,"no",-88.022002,43.04338,2019-12-01 -"75",89,"Intention Treatment for Anomia","Aphasia Stroke","May 24, 2021","NCT04267198","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia). Stroke-induced aphasia results in increased healthcare costs and decreased quality of life. As the population of Veterans continues to age, there will be an increasing number for Veterans living with the aphasia and its consequences. Those Veterans deserve to receive aphasia treatment designed to facilitate the best possible outcomes. In the proposed study, the investigators will investigate optimal treatment intensity and predictors of treatment response for a novel word retrieval treatment. The knowledge the investigators gain will have direct implications for the selecting the right treatment approach for the right Veteran.","Difficulty retrieving words is one of the most common language complaints in individuals with stroke-induced aphasia. The negative consequences related to word retrieval impairment include increased health care costs and decreased quality of life. A variety of treatment approaches exist to improve word retrieval, and most of the treatments result in immediate improvement on trained words. However, long-term improvement and improvement on untrained words or behaviors is less common. Additionally, the investigators currently know very little about optimal treatment administration parameters, and the investigators know even less about predictors of treatment response. To make the best use of the limited clinical resources available for aphasia treatment, and to maximize outcomes for Veterans with aphasia, the investigators must: 1) develop clinically translatable treatments that yield widespread and lasting effects and 2) develop clinically accessible ways of identifying who will acquire benefit from a specific treatment approach. This study takes on these two challenges by investigating dose frequency (massed vs. distributed practice) effects and by identifying the language, cognitive and neural predictors of response to Intention treatment (INT), a novel word retrieval treatment. Specifically, the investigators will address the following aims: +"74",88,"Intention Treatment for Anomia","Aphasia Stroke","May 24, 2021","NCT04267198","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia). Stroke-induced aphasia results in increased healthcare costs and decreased quality of life. As the population of Veterans continues to age, there will be an increasing number for Veterans living with the aphasia and its consequences. Those Veterans deserve to receive aphasia treatment designed to facilitate the best possible outcomes. In the proposed study, the investigators will investigate optimal treatment intensity and predictors of treatment response for a novel word retrieval treatment. The knowledge the investigators gain will have direct implications for the selecting the right treatment approach for the right Veteran.","Difficulty retrieving words is one of the most common language complaints in individuals with stroke-induced aphasia. The negative consequences related to word retrieval impairment include increased health care costs and decreased quality of life. A variety of treatment approaches exist to improve word retrieval, and most of the treatments result in immediate improvement on trained words. However, long-term improvement and improvement on untrained words or behaviors is less common. Additionally, the investigators currently know very little about optimal treatment administration parameters, and the investigators know even less about predictors of treatment response. To make the best use of the limited clinical resources available for aphasia treatment, and to maximize outcomes for Veterans with aphasia, the investigators must: 1) develop clinically translatable treatments that yield widespread and lasting effects and 2) develop clinically accessible ways of identifying who will acquire benefit from a specific treatment approach. This study takes on these two challenges by investigating dose frequency (massed vs. distributed practice) effects and by identifying the language, cognitive and neural predictors of response to Intention treatment (INT), a novel word retrieval treatment. Specifically, the investigators will address the following aims: Aim 1: To investigate dose frequency effects on maintenance and generalization of INT gains. Outcome measure: Word retrieval accuracy for trained and untrained words. @@ -1817,7 +1798,7 @@ Exclusion Criteria: Severe apraxia of speech or dysarthria Clinically significant depression For MRI safety: implanted medical devices, metal in the body and claustrophobia.","No","21 Years","All","Decatur","30033-4004","Georgia",NA,"United States",1,"no",-84.296069,33.773758,2021-05-24 -"76",90,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. +"75",90,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. All enrolled participants will be assessed on their mood, past music experience and music genre preference (music therapy assessment). They will complete the abridged Beck (BDI-2-fastscreen) questionnaire, the stoke and aphasia quality of life scale; a Likert which measures distress; the Western Aphasia Battery (WAB); the NIH Stroke Scale (SS); the Figely compassion scale; and the driving scene test (Stern and White); and the Rankin. In additional we will take saliva samples from all participants to measure hormone levels. @@ -1828,7 +1809,7 @@ Stroke victim, regardless of level of stroke Exclusion Criteria: None","No","18 Years","All","New York","10003","New York","Joanne Loewy","United States",1,"no",-73.953275,40.7898205,2014-04-04 -"77",97,"Home Program Practice for People With Language Disorders After Stroke","Aphasia Stroke","January 22, 2021","NCT04543084","Duquesne University Pittsburgh Pennsylvania United States","Duquesne University","Recruiting","Logbooks are one of the most commonly used methods to both support and track adherence in research studies. This study will look at using logbooks to support adherence to reading practice for individuals with post-stroke aphasia. It is thought that using a logbook will increase practice time.",NA,"","Interventional","Inclusion Criteria: +"76",97,"Home Program Practice for People With Language Disorders After Stroke","Aphasia Stroke","January 22, 2021","NCT04543084","Duquesne University Pittsburgh Pennsylvania United States","Duquesne University","Recruiting","Logbooks are one of the most commonly used methods to both support and track adherence in research studies. This study will look at using logbooks to support adherence to reading practice for individuals with post-stroke aphasia. It is thought that using a logbook will increase practice time.",NA,"","Interventional","Inclusion Criteria: at least 6 months post left hemisphere stroke with a diagnosis of aphasia must have self-reported interest in working to improve reading comprehension @@ -1840,7 +1821,7 @@ Exclusion Criteria: significant visual or hearing impairment as determined by ""aphasia-friendly"" and age-appropriate screening actively receiving speech-language pathology services in which computerized or reading comprehension home practice activities are assigned/requested severe auditory comprehension impairment that limits understanding of one-step directions (i.e., Western Aphasia Battery-Revised sequential commands subtest score below 8).","No","18 Years","All","Pittsburgh","15228","Pennsylvania",NA,"United States",1,"no",-79.991974,40.4375005,2021-01-22 -"78",98,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: +"77",98,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: Stroke Survivors: @@ -1865,7 +1846,7 @@ Additional Exclusion Criteria for MRIs: Pacemaker or magnetic metal in the body that is not MRI compatible Pregnancy Claustrophobia","Accepts Healthy Volunteers","18 Years","All","Washington","20057","District of Columbia",NA,"United States",1,"no",-77.078807,38.911961,2018-11-01 -"79",100,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: +"78",100,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: Diagnosis of aphasia secondary to stroke and presence of naming deficits (at least 20% errors on the Boston Naming Test or Hopkins Action Naming Assessment) Capable of giving informed consent or indicating another to provide informed consent @@ -1879,7 +1860,7 @@ Lack of English proficiency (by self/legally authorized representative report) Prior history of neurologic disease affecting the brain (e.g., brain tumor, multiple sclerosis, traumatic brain injury) other than stroke Prior history of severe psychiatric illness, developmental disorders or intellectual disability (e.g., PTSD, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders) Uncorrected severe visual loss or hearing loss by self-report and medical records","No","18 Years","All","Baltimore","21287","Maryland",NA,"United States",1,"no",-76.6204945,39.3289375,2023-05-31 -"80",102,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. +"79",102,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. However, language processes are not determined solely by local neural activity at a single site, but rather by the interaction between neural networks. This is because a large cortical network is involved in language processes and, therefore, the same language disorder may result from lesions at different locations in this network. @@ -1905,7 +1886,7 @@ Impaired alertness or delirium Severe co-morbidity affecting speech Contraindication to tDCS: pregnant women, patients with active implants such as pacemakers or cochlear implants, patients with one or more seizures, metal objects in the brain Occurrence of a new stroke during the study protocol.","No","18 Years","All","Geneva","1211","GE","Adrian Guggisberg","Switzerland",1,"no",6.1486155,46.1937405,2022-10-24 -"81",108,"Prism Adaptation in Left Brain Stroke","Aphasia Spatial Neglect Stroke","February 15, 2021","NCT04387162","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Of the 15,000 Veterans who are hospitalized for stroke each year more than half experience spatial and motor impairments and pain. Spatial-motor-sensory problems limit functioning and independence, which is costly to Veterans, their families, and society. Currently, spatial-motor-sensory problems are targeted using different treatments. However, there is a treatment that has shown promise in simultaneously targeting spatial function, motor function and pain in right-brain stroke. The investigators propose to investigate the feasibility of using adapted spatial-motor sensory assessment and treatment procedures for Veterans with left-brain stroke who have language and cognitive impairment. The next step will be to conduct a large-scale study focused on this multi-target treatment for more efficient and effective stroke rehabilitation. The investigators expect this line of research to increase functioning, independence and quality of life in Veteran stroke survivors.","The functional disability experienced by Veterans after stroke, and the limited rehabilitation resources available, highlight the importance of identifying feasible treatments acting on more than one recovery target. Currently, there are separate and modality-specific treatment pathways for cognitive and motor impairments. These modality-specific treatment pathways lead to fragmentation of care, and under-identification and under-treatment of invisible disabilities, such as spatial neglect, aphasia and pain. The result is longer hospital stays, greater risk of falls, and poor functional outcomes. Employing a treatment that simultaneously addresses multiple targets will ensure that the investigators provide the needed care for >50% of post-stroke Veterans who have both visible and invisible disabilities, during the critical post-acute period of recovery. +"80",108,"Prism Adaptation in Left Brain Stroke","Aphasia Spatial Neglect Stroke","February 15, 2021","NCT04387162","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Of the 15,000 Veterans who are hospitalized for stroke each year more than half experience spatial and motor impairments and pain. Spatial-motor-sensory problems limit functioning and independence, which is costly to Veterans, their families, and society. Currently, spatial-motor-sensory problems are targeted using different treatments. However, there is a treatment that has shown promise in simultaneously targeting spatial function, motor function and pain in right-brain stroke. The investigators propose to investigate the feasibility of using adapted spatial-motor sensory assessment and treatment procedures for Veterans with left-brain stroke who have language and cognitive impairment. The next step will be to conduct a large-scale study focused on this multi-target treatment for more efficient and effective stroke rehabilitation. The investigators expect this line of research to increase functioning, independence and quality of life in Veteran stroke survivors.","The functional disability experienced by Veterans after stroke, and the limited rehabilitation resources available, highlight the importance of identifying feasible treatments acting on more than one recovery target. Currently, there are separate and modality-specific treatment pathways for cognitive and motor impairments. These modality-specific treatment pathways lead to fragmentation of care, and under-identification and under-treatment of invisible disabilities, such as spatial neglect, aphasia and pain. The result is longer hospital stays, greater risk of falls, and poor functional outcomes. Employing a treatment that simultaneously addresses multiple targets will ensure that the investigators provide the needed care for >50% of post-stroke Veterans who have both visible and invisible disabilities, during the critical post-acute period of recovery. Prism adaptation treatment (PAT) is a 10-day regimen reported to be inexpensive, replicable and effective for treatment of spatial neglect, and studies have demonstrated that it also enhances everyday activities and motor recovery and reduces chronic post-stroke pain in patients with right brain stroke. Additionally, brain mapping methods have shown that in patients with right brain stroke, those with frontal lesions respond optimally to PAT. No studies have investigated PAT in left-brain stroke patients with language and cognitive impairment. To address this research gap, the investigators will address the following aims: @@ -1924,7 +1905,7 @@ able to provide informed consent to participate, using aphasia-accessible proces Exclusion Criteria: History of brain conditions other than left brain stroke, including clinical right brain pathology.","No","18 Years","All","Decatur","30033-4004","Georgia",NA,"United States",1,"no",-84.296069,33.773758,2021-02-15 -"82",113,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: +"81",113,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: Posterior cortical atrophy - a version of Alzheimer's disease with vision difficulties Logopenic variant primary progressive aphasia - a version of Alzheimer's disease with language difficulties @@ -1958,7 +1939,7 @@ Conditions precluding entry into the scanners (e.g. morbid obesity, claustrophob Exposure to research related radiation in the past year that, when combined with this study, would place subjects above the allowable limits. Participation in the last year in a clinical trial for a disease modifying drug for AD. Taking immunosuppressive medication (e.g., glucocorticoids, cytostatics, antibodies, drugs acting on immunophilins, interferons, tumor necrosis factor inhibitors). Nonsteroidal anti-inflammatory drugs (NSAIDs) are not exclusionary.","Accepts Healthy Volunteers","50 Years","All","New York","10032","New York","James M Noble, MD, MS, CPH, FAAN","United States",1,"no",-73.9622875,40.807223,2020-11-17 -"83",166,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: +"82",166,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: to evaluate the residual neuroplastic processes in DOC state related to music exposure to determine the putative modulation of the aforementioned processes and the clinical outcome of DOC patients by non-pharmacological strategies, i.e., electric (tDCS) and music stimulation @@ -1979,9 +1960,9 @@ No hystory of psychiatric disease Previous stroke use of alcohol and drugs premorbid dementia","No","18 Years","All","Bari","70025","Ba","Simona Spaccavento","Italy",1,"no",16.862029,41.125784,2022-09-01 -"84",NA,"Functional reorganization of the language and domain-general multiple demand systems in aphasia",NA,"March 1, 2022","manual1","Boston, MA","Boston University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Boston",NA,"Massachusetts","Swathi Kiran",NA,NA,"no",-71.058291,42.360253,2022-03-01 -"85",NA,"Characterizing inner speech in aphasia",NA,"March 9, 2022","manual2","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 -"86",NA,"Inner speech as a naming therapy predictor in aphasia",NA,"March 9, 2022","manual3","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 -"87",NA,"Measuring and understanding the experience of post-traumatic growth in aphasia",NA,"March 9, 2022","manual4","Reno, NV","University of Nevada Reno",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Reno",NA,"Nevada","Tami Brancamp",NA,NA,"Online",-119.812658,39.526121,2022-03-09 -"88",NA,"Reading in Aphasia",NA,"January 1, 2020","manual5","Atlanta, GA","Georgia State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Atlanta",NA,"GA","Rachael Harrington",NA,NA,"Online",-84.390264,33.748992,2020-01-01 -"89",NA,"Assessment of anomia: Improving efficiency and utility using item response theory",NA,"August 31, 2020","manual6","Portland, OR","Portland State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Portland",NA,"OR","Gerasimos Fergadiotis",NA,NA,"no",-122.674195,45.520247,2020-08-31 +"83",NA,"Functional reorganization of the language and domain-general multiple demand systems in aphasia",NA,"March 1, 2022","manual1","Boston, MA","Boston University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Boston",NA,"Massachusetts","Swathi Kiran",NA,NA,"no",-71.058291,42.360253,2022-03-01 +"84",NA,"Characterizing inner speech in aphasia",NA,"March 9, 2022","manual2","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 +"85",NA,"Inner speech as a naming therapy predictor in aphasia",NA,"March 9, 2022","manual3","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 +"86",NA,"Measuring and understanding the experience of post-traumatic growth in aphasia",NA,"March 9, 2022","manual4","Reno, NV","University of Nevada Reno",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Reno",NA,"Nevada","Tami Brancamp",NA,NA,"Online",-119.812658,39.526121,2022-03-09 +"87",NA,"Reading in Aphasia",NA,"January 1, 2020","manual5","Atlanta, GA","Georgia State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Atlanta",NA,"GA","Rachael Harrington",NA,NA,"Online",-84.390264,33.748992,2020-01-01 +"88",NA,"Assessment of anomia: Improving efficiency and utility using item response theory",NA,"August 31, 2020","manual6","Portland, OR","Portland State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Portland",NA,"OR","Gerasimos Fergadiotis",NA,NA,"no",-122.674195,45.520247,2020-08-31 diff --git a/data/contact.rds b/data/contact.rds index 584f95e22b8cca485e0b765ea7c5779013fbcd63..a8dd29feac6ecd38d76d4533955c253c67921cfc 100644 GIT binary patch delta 171 zcmcZ|vLJYZEMxLUIRnPcHH_`d!ivuMr9~xqsg-)Z$-(8RsX*3dQP%5hjLDPVa$nv2 ziYI_c+1$`VQ^DB4Lf6v7)PRA7fs=uOflmWPbaO2KUKYmW&C()LjGNO$RhWf^UI_?oc!e5a%(oPm9GVIH*2fCV4AG1sW;g`lVx(K=1#`BllirL0E_iBZU6uP delta 311 zcmZ1wd^==+*{?BrNjWKod0q&~`rUr((W(LN(h6aX~P;+=7 zVum0w!_B=s5lqTPhDMqS7Dgrt7RF{UWqcYaqMJGR_p&giZayX~#i%71kY7}inW*3l zbf%6%K!%23hq_ZC2c+EI_a)_o60L!XVCjbBd diff --git a/data/data_dt.rds b/data/data_dt.rds index 34c31b78167eb8ba4ed3f4f8dd13134993ab9f46..99e0950dee8aa23364b2bea0437bb69efae36c6c 100644 GIT binary patch delta 110 zcmZ3|$~duwae^#k#74QFOq+w5_e(NHOcs{)+MFu8iV4URP*}cszrr&XAoGl>{Nx*| z!a&@%xlnCCD`UiFLmfZH$%Urcn@{LUa0B@dEnJx=8`x}MTrv5f%`Tw899t!p$)_Br J0RP;Lk diff --git a/data/study_info.rds b/data/study_info.rds index 5b7e153dfeaa8549259d6f7060b45cde016f5d5f..692d0b631d98d8ecdeb12c8208d193dcb853aa28 100644 GIT binary patch delta 456 zcmY+;JxGF46b4}LJ!R03iuF+lSt;gFR8*Kne2Pm21wmO&CJhY{6osSoLqBWcaEC-N z5G5R;i}uz?*M&Fbd-^1=BDCewc%KScp7(n5x;B z!nI90HZe77Y|2E}nvI&GOje^^vTSKzmf9+mzt%_XyX~z83!hFW60M~>X4a~`%Q4ie zPlJKOf{)39k3Z}&Rc7w^K8prh^wM+Bk7}7JvN;|S?mQ36?HmtMxzsTDk>_cX{CVeg zbYeYD1HvDtSy7Brx5Tl*5s#dZTdX8#LcS!Zhp?7N(km0eB<+cV6uB^SlcHTYmL>!K yCIcBNG2Gru$}+KjN_ycqqn%1}PT@*Ze!jV&-T#SE(&E2Fs#oOV>{f)XY4Q&Wmx46_ delta 3026 zcmZ`*?{6H%8NS`g4>%gf)OH{UoJj-3C+_UniG!g~$Ak){O{n8qEv-bA@$TH+*n2yh znc0|&KrX0lqzaLk1Ez=+SqLFSD^X#j>xUARuTiP^(5h-bfcg)VR%%tX5^A5>J)fOR zi1OO&*_rpp^FGfz`@>KBKKyszrMtZ8)!~Ep6bpsImtebKeXxGmt*`;uAZ!S>XLWJk z1N-o>ANCd40odKJdtnD*W!M<(5NsTF7&Zla5ccrum3`j#RzI2crq_qPA-{6uL?dB= zp|VOJQ!-8HEK^1VB4I|znBxCTm_|m^?+R02zni?%?@hPXhG^@vf#)AQK9kg$7OYHX zg0rbmJfzD_-1^Uf;nsTx?px>kezOzFt{v2*b@AXO`_I=&f9qF!@5S0T?z{Zu zUEYcLI;Tmh5~+D>_JzS?{3+HDF{cLWqFY@pt1juSj^))YqdLm+YV2Cc8?=W~|CR&V zusCEYq>17cJW>QP6{a=Uy1`=yTkE$!8@y>mC!7cMvVC0mcdm>{MVFN@BCeH2DbkB+ zH*O3lmqip&W(_qhWdp$?7tqVuvuzv2G=fA6Sn=lxtUi0?7LA@^;zew7=7O7yZGn zHIhg+DWho&-wGj`l^_x^GGAaCRFSE1EORjC#TrRj2sDJNszrak$G*Pb-?0L015w2> zCK}oi)#P=iA-pT}S<;Z>MAmfFc%x3EE+x-#O-IH{G!j)X<{Bn2O&gr))KPe$3238g zMe#%`Ll@7cfEmTc3=9VpBNHWnhk)mhI@T-Q1ba}UJzfoZYaDIhI${Q)Ix&$JAFYj+ z?dc2N9y@);+g^420YNB#3e?LuP|CojBZo^g;i@WCBWoiR8Y73yH#~MzFi4u}K;m?7 z9;~~|{^NdckQ9rv_V1y8$I6k)Bq|Hh=rCmwbuJv~x+KiA#1_y6@3-h6(*`s$mIiz7=n9cE}c2Y*++ous}%-nqV3V#K{8aOx_#f z5P-Uq1Uk`CteZkTTF&%emBH>5bdH_oz)b+X+5WxPx1Z)p%!boLS>ky~h?L+7!xeq* z0OGpwh2b~H+sbj7pe}5l;{j@<^BV-EBgbdv=1X*0swG|L+&EfnGyqsYa#a@O^F14~ zPFxwd*tjwK=n`+jL8vj)a=PP~gTrO-c(vF7)(T7lj4mF|o|BPNX@JDs4#QLp!E-M; z$7Idv0ej%AGh{pOt4cQDJF8^m5ze)nPdLq@(b8tocJ6{Vbb3o=&Ml8??sh`%q0m8^ z=?$)G82woqNV_|@iX4Q$_?5UGQ;wTzrayf6!E|*-$i9Hi<;;0 z2TF0g$%Yw1xyzZAl#IiuXlo6k^~x`HmjO+jW4SSXa^bjaCMrfiu!+R{bRD#RYkIfa<&V6+ z5zO@**(hD;8P1q>Jt8TWv)*4jAoKZn{cyi-{HmYYD?>ObNBUdIXbd;jfz-&?TWb~40fP}=wuZE~g{ zUPWbuubHAlsv*^aa9;`%cU5+);a*@%9DAzt>v1g-x?X%#uv(1kHoM2NZ;uLYcSq9v z+oSj$`|KDQ*q>H6oOHN>!Ip8b^WmW_yM^3#=5a}J7aFOWE=W)pQCOEUr1|HF%ddMM zgu=OW!;9 - - + + @@ -2213,7 +2213,7 @@ color: var(--hover-color, white); } - + diff --git a/docs/about.html b/docs/about.html index 7f1108a..b00a2ee 100644 --- a/docs/about.html +++ b/docs/about.html @@ -456,8 +456,8 @@ - - + + @@ -2280,7 +2280,7 @@ color: var(--hover-color, white); } - + @@ -2344,7 +2344,7 @@

About this Website

This website was built primarily using data from the clinicaltrials.gov API to identify studies that included a keyword or condition listing of Aphasia (excluding primary progressive aphasia and other dementias.)

-

It was last updated on August 14 2023

+

It was last updated on August 21 2023

To add your study to this website, submit the study to clinicaltrials.gov. This has a number of benefits for the research community and general public. While submission to clinicaltrials.gov is required for funded clinical trials in the US, voluntary submission is also permitted for other studies.

If submitting your study to clinicaltrials.gov is not feasible or is overly burdensome, you can add an IRB-approved flyer to the website by submitting an issue on github.com. Note that you will will need to create a github account. This is free and helps me keep track of submissions.

If you notice an error on the website, please contact me or file an issue here.

diff --git a/docs/data/clinical_trials_clean.csv b/docs/data/clinical_trials_clean.csv index e47ac2f..b80b8ca 100644 --- a/docs/data/clinical_trials_clean.csv +++ b/docs/data/clinical_trials_clean.csv @@ -234,26 +234,7 @@ passed an audiometric pure-tone, air conduction screening at 25 dB HL at 1K, 2K Exclusion Criteria: English as a second language Right hemisphere stroke Less than 6 months post-onset of stroke.",NA,"21 Years","All","Seattle","98105","Washington","Nadine Martin","United States",1,"no",-122.290177,47.538942,2017-12-15 -"10",7,"Impact of Group Participation on Adults With Aphasia","Aphasia, Acquired Stroke Rehabilitation Language Disorder, Acquired","September 6, 2022","NCT05520528","University of Arkansas Little Rock Arkansas United States","University of Arkansas","Recruiting","The purpose of the study is to examine the impact of group participation on adults with aphasia. Participants will complete a standard pre-and post-assessment of language abilities (speech, comprehension, reading, and/or writing). Then participants will attend 90-minute weekly reading group sessions during an academic semester.","The objective of this research is to determine if attendance in groups positively impacts language skills, activity/participation, and/or quality of life in persons with aphasia. - -This study will employ a university-clinic based outpatient group to administer language intervention. The specific aims of this study are to determine if group participation improves (1) life participation as measured by self-report questionnaires, (2) intervention-specific language skills as measured by treatment-related measures (e.g., reading comprehension and written expression), and (3) performance on non-treated language test scores as measured by a language assessment battery. - -Participants will complete 4-5 individual testing sessions (e.g., initial assessment and pre-/post-testing), 7-12 group sessions (90-minute weekly reading group session), and 7-12 independent sessions at home (e.g., completion of weekly reading assignments). - -The participants will read through a designated book incrementally across multiple weeks. The activities completed during the group sessions will focus on improving reading comprehension and written expression skills. Participants will read assigned passages at home and during the group sessions. Participants will complete a Copy and Recall Treatment (CART) worksheet independently to facilitate improvements in writing keywords related to the reading materials. CART involves copying target words and progresses to writing words from recall (Beeson, et al.). Participants will complete a reading comprehension worksheet and engage in discussion regarding the assigned book chapter. - -Reading comprehension and written expression data will be collected and analyzed to compare the pre-treatment baseline performance from the first treatment session to the post-treatment performance from the last treatment session. Pre-and post-testing scores will be analyzed to investigate the change in scores across the 2-time points to determine the relative effectiveness of book club participation for improving reading comprehension, written expression, and life participation.","","Interventional","Inclusion Criteria: - -Age 18 years or older -Pre-morbid proficient speaker of English -Diagnosis of adult-onset aphasia -Vision and hearing sufficient to complete assessments - -Exclusion Criteria: - -No history of childhood speech or language difficulties -No history of major psychiatric illness, cognitive impairment, or neurological disorders such as seizures","No","18 Years","All","Little Rock","72204","Arkansas",NA,"United States",1,"no",-92.3396525,34.7224165,2022-09-06 -"11",8,"Incorporating Strategy Training Into Naming Treatment in Aphasia","Aphasia","August 30, 2021","NCT05307796","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","This study incorporates metacognitive strategy training into semantic feature analysis treatment. Semantic feature analysis treatment has a strong evidence base and capacity to improve word retrieval by encouraging circumlocution. Circumlocution facilitates self-cued naming and assists listener comprehension when naming fails. However, semantic feature analysis treatment does not include direct techniques to teach patients with aphasia to generalize the use of semantic feature analysis treatment's circumlocution procedure. Therefore, this study proposes that combining semantic feature analysis treatment and metacognitive strategy training will stimulate the semantic system and increase patients with aphasias' use of circumlocution across divergent contexts. +"10",7,"Incorporating Strategy Training Into Naming Treatment in Aphasia","Aphasia","August 30, 2021","NCT05307796","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","This study incorporates metacognitive strategy training into semantic feature analysis treatment. Semantic feature analysis treatment has a strong evidence base and capacity to improve word retrieval by encouraging circumlocution. Circumlocution facilitates self-cued naming and assists listener comprehension when naming fails. However, semantic feature analysis treatment does not include direct techniques to teach patients with aphasia to generalize the use of semantic feature analysis treatment's circumlocution procedure. Therefore, this study proposes that combining semantic feature analysis treatment and metacognitive strategy training will stimulate the semantic system and increase patients with aphasias' use of circumlocution across divergent contexts. This study aims to measure the treatment's effect on naming accuracy for trained and untrained items. The study also aim to measure the treatment's effect on people with aphasias' knowledge of the strategy components and changes in verbalizations during retrieval attempts. The central hypothesis is that strategy training will increase patients with aphasias' explicit knowledge about circumlocution and enable them to use it to (1) self-facilitate naming, and (2) produce more informative connected speech.","Every 40 seconds, someone in the United States suffers from a stroke. Approximately 25% of stroke survivors acquire aphasia, a communication disorder that can result in a partial or total loss of spoken and written language ability, which significantly and negatively impacts quality of life and societal participation. The ability to verbally label objects, referred to as 'naming' in the literature, is impaired in all patients with aphasia. Naming is, therefore, a common focus of treatment. Naming treatments improve people with aphasias' naming ability for items that are directly trained during therapy. However, these same treatments face two critical limitations: (1) inconsistent generalization to untrained items, and (2) little to no generalization to spontaneous, connected speech. As it is impossible to train the entire universe of objects during a patient's course of therapy, generalization of gains beyond what is trained in therapy is crucial. @@ -275,7 +256,7 @@ Exclusion criteria: Experienced multiple strokes; Be in the acute stage of their aphasia, <6 months post onset of stroke; Have a diagnosis of neurodegenerative disease, significant mental illness, psychiatric disorder, drug/alcohol abuse, or neurological condition that could influence cognitive, language, and memory systems","No","18 Years","All","Boston","02129","Massachusetts","Sofia Vallila Rohter","United States",1,"no",-71.0537615,42.3756115,2021-08-30 -"12",9,"Speech Entrainment for Aphasia Recovery","Aphasia Aphasia Non Fluent Stroke","August 21, 2020","NCT04364854","Medical University of South Carolina Charleston South Carolina United States","Medical University of South Carolina","Recruiting","After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production. +"11",8,"Speech Entrainment for Aphasia Recovery","Aphasia Aphasia Non Fluent Stroke","August 21, 2020","NCT04364854","Medical University of South Carolina Charleston South Carolina United States","Medical University of South Carolina","Recruiting","After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production. Participants who are eligible will undergo baseline language testing, an MRI, and will be randomized into one of 4 treatment groups: SET for 3 weeks, SET for 4.5 weeks, SET for 6 weeks, and no treatment (control group).",NA,"Aphasia Speech Language Pathology Therapy","Interventional","Inclusion Criteria @@ -299,7 +280,7 @@ Uncorrectable hearing as determined by the SLP's clinical judgment. Uncorrectable vision. Contraindications to MRI or inability to complete the MRI scanning session. Women who are pregnant.","No","21 Years","All","Charleston","29401","South Carolina","Leonardo Bonilha","United States",1,"no",-79.947297,32.784808,2020-08-21 -"13",9,"Speech Entrainment for Aphasia Recovery","Aphasia Aphasia Non Fluent Stroke","August 21, 2020","NCT04364854","Medical University of South Carolina Columbia South Carolina United States","Medical University of South Carolina","Recruiting","After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production. +"12",8,"Speech Entrainment for Aphasia Recovery","Aphasia Aphasia Non Fluent Stroke","August 21, 2020","NCT04364854","Medical University of South Carolina Columbia South Carolina United States","Medical University of South Carolina","Recruiting","After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production. Participants who are eligible will undergo baseline language testing, an MRI, and will be randomized into one of 4 treatment groups: SET for 3 weeks, SET for 4.5 weeks, SET for 6 weeks, and no treatment (control group).",NA,"Aphasia Speech Language Pathology Therapy","Interventional","Inclusion Criteria @@ -323,7 +304,7 @@ Uncorrectable hearing as determined by the SLP's clinical judgment. Uncorrectable vision. Contraindications to MRI or inability to complete the MRI scanning session. Women who are pregnant.","No","21 Years","All","Columbia","29208","South Carolina","Leonardo Bonilha","United States",1,"no",-81.026403,33.997832,2020-08-21 -"14",9,"Speech Entrainment for Aphasia Recovery","Aphasia Aphasia Non Fluent Stroke","August 21, 2020","NCT04364854","Medical University of South Carolina Salt Lake City Utah United States","Medical University of South Carolina","Recruiting","After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production. +"13",8,"Speech Entrainment for Aphasia Recovery","Aphasia Aphasia Non Fluent Stroke","August 21, 2020","NCT04364854","Medical University of South Carolina Salt Lake City Utah United States","Medical University of South Carolina","Recruiting","After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production. Participants who are eligible will undergo baseline language testing, an MRI, and will be randomized into one of 4 treatment groups: SET for 3 weeks, SET for 4.5 weeks, SET for 6 weeks, and no treatment (control group).",NA,"Aphasia Speech Language Pathology Therapy","Interventional","Inclusion Criteria @@ -347,7 +328,7 @@ Uncorrectable hearing as determined by the SLP's clinical judgment. Uncorrectable vision. Contraindications to MRI or inability to complete the MRI scanning session. Women who are pregnant.","No","21 Years","All","Salt Lake City","84112","Utah","Leonardo Bonilha","United States",1,"no",-111.915493,40.77689,2020-08-21 -"15",10,"DUbbing Language-therapy CINEma-based in Aphasia Post-Stroke","Aphasia, Post-Ictal","December 18, 2020","NCT04289493","Instituto de Investigación Hospital Universitario La Paz Madrid NA Spain","Instituto de Investigación Hospital Universitario La Paz","Recruiting","The DULCINEA study aims to develop and validate a new therapy that integrates essential language characteristics and functional communication by dubbing scenes from television series that represent daily situations. It will be a randomized, crossed over, interventional pilot study recruiting 54 patients with poststroke nonfluent aphasia. Patients will be treated individually in 40-minute sessions twice a week for 8 weeks. In each session, a speech therapist and an actor will select the clips with muted words or sentences that have been detected as functionally meaningful for each patient. Outcomes will be assessed as significant differences in two aphasia tests.","The DULCINEA study aims to develop and validate a new therapy that integrates essential language characteristics and functional communication by dubbing scenes from TV series that represent daily situations. It will be a randomized, crossed over, interventional pilot study recruiting 54 patients with poststroke nonfluent aphasia from the departments of Neurology and Rehabilitation from La Paz University Hospital and also from the ""Afasia Activa"" association. After meeting all inclusion and none of the exclusion criteria and signing informed consent, patients will be randomised (1:1) in two different treatment groups. The first group will receive therapy within the first 3 months of their inclusion with a subsequent period of another 3 months without therapy (thus, serving as group 2 controls). Group 2 will initiate therapy after 3 months since their inclusion (serving as group 1 controls during the first 3 months). Therapy consists of 17 sessions performed in a eight week period (1 baseline session and 16 dubbing sessions), each lasting 40 minutes, in which the patient will be asked to dubb words or sentences previously selected and considered as functionally meaningful for them. These words will be chosen through an online survey performed by a representative group of aphasic patients and the study patients´own relatives in the baseline treatment session. Outcomes will be assessed as significant differences in two aphasia tests (CAL questionnaire and the BDAE).","Rehabilitation Word dubbing Functional communication","Interventional","Inclusion Criteria: +"14",9,"DUbbing Language-therapy CINEma-based in Aphasia Post-Stroke","Aphasia, Post-Ictal","December 18, 2020","NCT04289493","Instituto de Investigación Hospital Universitario La Paz Madrid NA Spain","Instituto de Investigación Hospital Universitario La Paz","Recruiting","The DULCINEA study aims to develop and validate a new therapy that integrates essential language characteristics and functional communication by dubbing scenes from television series that represent daily situations. It will be a randomized, crossed over, interventional pilot study recruiting 54 patients with poststroke nonfluent aphasia. Patients will be treated individually in 40-minute sessions twice a week for 8 weeks. In each session, a speech therapist and an actor will select the clips with muted words or sentences that have been detected as functionally meaningful for each patient. Outcomes will be assessed as significant differences in two aphasia tests.","The DULCINEA study aims to develop and validate a new therapy that integrates essential language characteristics and functional communication by dubbing scenes from TV series that represent daily situations. It will be a randomized, crossed over, interventional pilot study recruiting 54 patients with poststroke nonfluent aphasia from the departments of Neurology and Rehabilitation from La Paz University Hospital and also from the ""Afasia Activa"" association. After meeting all inclusion and none of the exclusion criteria and signing informed consent, patients will be randomised (1:1) in two different treatment groups. The first group will receive therapy within the first 3 months of their inclusion with a subsequent period of another 3 months without therapy (thus, serving as group 2 controls). Group 2 will initiate therapy after 3 months since their inclusion (serving as group 1 controls during the first 3 months). Therapy consists of 17 sessions performed in a eight week period (1 baseline session and 16 dubbing sessions), each lasting 40 minutes, in which the patient will be asked to dubb words or sentences previously selected and considered as functionally meaningful for them. These words will be chosen through an online survey performed by a representative group of aphasic patients and the study patients´own relatives in the baseline treatment session. Outcomes will be assessed as significant differences in two aphasia tests (CAL questionnaire and the BDAE).","Rehabilitation Word dubbing Functional communication","Interventional","Inclusion Criteria: nonfluent aphasia due to unilateral stroke in the left hemisphere without neuroimaging evidence of lesions in the right hemisphere. the patient should have received a standard program of conventional speech therapy after stroke, remaining with aphasia with the following characteristics: severely restricted language, poor repetition (even for single words), not exceeding the 70th percentile in the Boston Diagnostic Aphasia Examination (BDAE) for repetition. Moderately preserved language comprehension: listening comprehension exceeding the 15th percentile of BDAE (average score obtained in three areas: word comprehension, commands and complex ideational material). @@ -357,7 +338,7 @@ Exclusion Criteria: Any clinical condition (short life expectancy, coexisting disease) or other characteristics that precluded appropriate follow-up. Participation in any therapeutic trial evaluating poststroke recovery.","No",NA,"All","Madrid","28046",NA,NA,"Spain",1,"no",-3.6871885,40.4807815,2020-12-18 -"16",12,"Establishment of Virtual Reality System for Stroke Patients With Aphasia","Aphasia","April 7, 2022","NCT05606393","Taipei Veterans General Hospital, Taiwan Taipei city NA Taiwan","Taipei Veterans General Hospital, Taiwan","Recruiting","Aphasia can significantly influence a person's social relationship and quality of life. To achieve positive language outcomes, an intensive and high-repetition speech therapy is essential. However, due to the limited number of speech therapists, the intensity and frequency of training are often insufficient. Therefore, it is critical to develop other rehabilitation approaches to enhance the benefits of aphasia intervention. Virtual reality (VR) is an immersive and interactive computer simulation technology that can promote the ecological validity of speech therapy. In this study, we develop an innovative VR software for speech training to explore the effects of VR on various aspects of language outcomes.","We randomly assigned study participants into 2 groups: the traditional speech therapy (ST) group and the traditional ST with additional VR training (ST+VR) group. In the ST group, each participant received 1-hour traditional ST for each session. In the ST+VR group, an additional 30-minute VR training was administered immediately after each session of traditional ST. All participants received 3 sessions of treatment every week for 3 weeks. For outcome measurement, we administered Concise Chinese Aphasia Test (CCAT) at 3 different time points: before treatment, 1 day and 3 months after the completion of treatment.","virtual reality aphasia language rehabilitation stroke","Interventional","Inclusion Criteria: +"15",11,"Establishment of Virtual Reality System for Stroke Patients With Aphasia","Aphasia","April 7, 2022","NCT05606393","Taipei Veterans General Hospital, Taiwan Taipei city NA Taiwan","Taipei Veterans General Hospital, Taiwan","Recruiting","Aphasia can significantly influence a person's social relationship and quality of life. To achieve positive language outcomes, an intensive and high-repetition speech therapy is essential. However, due to the limited number of speech therapists, the intensity and frequency of training are often insufficient. Therefore, it is critical to develop other rehabilitation approaches to enhance the benefits of aphasia intervention. Virtual reality (VR) is an immersive and interactive computer simulation technology that can promote the ecological validity of speech therapy. In this study, we develop an innovative VR software for speech training to explore the effects of VR on various aspects of language outcomes.","We randomly assigned study participants into 2 groups: the traditional speech therapy (ST) group and the traditional ST with additional VR training (ST+VR) group. In the ST group, each participant received 1-hour traditional ST for each session. In the ST+VR group, an additional 30-minute VR training was administered immediately after each session of traditional ST. All participants received 3 sessions of treatment every week for 3 weeks. For outcome measurement, we administered Concise Chinese Aphasia Test (CCAT) at 3 different time points: before treatment, 1 day and 3 months after the completion of treatment.","virtual reality aphasia language rehabilitation stroke","Interventional","Inclusion Criteria: Diagnosis of stroke with aphasia, including fluent and non-fluent types Age between 20~80-year-old @@ -374,7 +355,7 @@ Unable to learn how to use the virtual reality controller and device Any medical diseases or unstable vital signs that may cause safety concern Severe hearing or vision impairments Have ever received any form of speech therapy or virtual reality training","No","20 Years","All","Taipei city",NA,NA,NA,"Taiwan",1,"no",121.519937,25.1193725,2022-04-07 -"17",13,"Efficacy of Low-frequency rTMS in Aphasia","Aphasia","July 18, 2022","NCT05450341","Medipol University Istanbul NA Turkey","Medipol University","Recruiting","In a randomized controlled trial, efficacy of low-frequency, inhibitory rTMS will be examined in rehabilitation of acquired aphasia. Two cortical sites will be targeted: Right-hemispheric homologues of Broca's and Wernicke's areas. +"16",12,"Efficacy of Low-frequency rTMS in Aphasia","Aphasia","July 18, 2022","NCT05450341","Medipol University Istanbul NA Turkey","Medipol University","Recruiting","In a randomized controlled trial, efficacy of low-frequency, inhibitory rTMS will be examined in rehabilitation of acquired aphasia. Two cortical sites will be targeted: Right-hemispheric homologues of Broca's and Wernicke's areas. In addition to cognitive screening prior to onset of rTMS, language assessments will be conducted before, during and after the intervention. An eyetracking-while-listening experiment will also be conducted before and after the intervention to investigate morphosyntactic processing.","Efficacy of low-frequency (1hz), inhibitory rTMS will be examined in rehabilitation of acquired aphasia. Two cortical sites will be targeted: Right-hemispheric homologues of Broca's and Wernicke's areas. In other words, right frontal and right temporal sites will be targeted. @@ -399,7 +380,7 @@ Violating current TMS safety guidelines (Rossi et al. 2009, 2021). In other word Having a previous history of epilepsy, Having an implant (e.g., cochlear implant) or stimulator (e.g., deep brain stimulation) in the head which may interact with the magnetic field, Taking central nervous system active drugs that lower seizure threshold (as listed in the aforementioned guidelines)","No","18 Years","All","Istanbul","34815",NA,"Talat Bulut","Turkey",1,"no",28.942965,41.020518,2022-07-18 -"18",14,"Effects of Neuronavigated Theta Burst Stimulation in Therapy of Post-stroke Aphasia","Stroke, Ischemic Aphasia Non Fluent","September 2, 2022","NCT05303649","Institute of Psychiatry and Neurology, Warsaw Warsaw Masovian Voivodeship Poland","Institute of Psychiatry and Neurology, Warsaw","Recruiting","Aphasia is an impairment in the ability to express and/or understand language, commonly observed after stroke to the language dominant (left) hemisphere. Despite natural tendency to spontaneous functional recovery in the first months post stroke and language improvement due to application of behavioral speech and language therapy (SLT), many aphasic patients do not achieve satisfactory level of verbal communication. The aim of the planned study is to explore the potential of the noninvasive repetitive Transcranial Magnetic Stimulation (rTMS) as a therapeutic tool for aphasia in addition to traditional behavioral therapy. In case of aphasia, studies on therapeutic effectiveness of rTMS aim to increase the activity of the language-dominant left cerebral hemisphere, which may be achieved in an indirect manner by inhibiting the activity of the opposite (right) hemisphere or in a direct manner by increasing the excitability of preserved language areas in the left hemisphere. In our study, we plan to administer the newest form of rTMS called Theta Burst Stimulation (TBS), which is safer than the conventional rTMS, even when used in the perilesional area. Computer-based neuronavigation system will be implemented to precisely localize stimulation targets, control administration of stimuli during rTMS sessions, and evaluate differences between participants regarding deviations from established stimulation points. 45 patients (all right-handed, polish native speakers, aged 18-75 years, diagnosed with non-fluent aphasia) will be enrolled in a randomized, double-blind, sham-controlled trial. Subjects will be randomly assigned to one of the three groups: 1) a group with excitatory intermittent TBS of the left hemisphere (iTBS group), 2) a group with inhibitory continuous TBS of the right hemisphere (cTBS group), 3) a group with sham TBS (sTBS group as a control group). Specific forms of stimulation will be carried out for three consecutive weeks (Monday to Friday; a total of 15 stimulation sessions). Immediately after each session of the stimulation, patients will undergo individual SLT. Assessment of language functioning will be carried out three times: before and after the therapy period, and 3 months after its completion. Results of the study will broaden knowledge about hemispherical mechanisms of language and speech recovery after stroke and provide insight into possibilities of their modulation for the purpose of post-stroke rehabilitation.",NA,"Aphasia Stroke Theta Burst Stimulation Therapy Rehabilitation Noninvasive Transcranial Brain Stimulation","Interventional","Inclusion Criteria: +"17",13,"Effects of Neuronavigated Theta Burst Stimulation in Therapy of Post-stroke Aphasia","Stroke, Ischemic Aphasia Non Fluent","September 2, 2022","NCT05303649","Institute of Psychiatry and Neurology, Warsaw Warsaw Masovian Voivodeship Poland","Institute of Psychiatry and Neurology, Warsaw","Recruiting","Aphasia is an impairment in the ability to express and/or understand language, commonly observed after stroke to the language dominant (left) hemisphere. Despite natural tendency to spontaneous functional recovery in the first months post stroke and language improvement due to application of behavioral speech and language therapy (SLT), many aphasic patients do not achieve satisfactory level of verbal communication. The aim of the planned study is to explore the potential of the noninvasive repetitive Transcranial Magnetic Stimulation (rTMS) as a therapeutic tool for aphasia in addition to traditional behavioral therapy. In case of aphasia, studies on therapeutic effectiveness of rTMS aim to increase the activity of the language-dominant left cerebral hemisphere, which may be achieved in an indirect manner by inhibiting the activity of the opposite (right) hemisphere or in a direct manner by increasing the excitability of preserved language areas in the left hemisphere. In our study, we plan to administer the newest form of rTMS called Theta Burst Stimulation (TBS), which is safer than the conventional rTMS, even when used in the perilesional area. Computer-based neuronavigation system will be implemented to precisely localize stimulation targets, control administration of stimuli during rTMS sessions, and evaluate differences between participants regarding deviations from established stimulation points. 45 patients (all right-handed, polish native speakers, aged 18-75 years, diagnosed with non-fluent aphasia) will be enrolled in a randomized, double-blind, sham-controlled trial. Subjects will be randomly assigned to one of the three groups: 1) a group with excitatory intermittent TBS of the left hemisphere (iTBS group), 2) a group with inhibitory continuous TBS of the right hemisphere (cTBS group), 3) a group with sham TBS (sTBS group as a control group). Specific forms of stimulation will be carried out for three consecutive weeks (Monday to Friday; a total of 15 stimulation sessions). Immediately after each session of the stimulation, patients will undergo individual SLT. Assessment of language functioning will be carried out three times: before and after the therapy period, and 3 months after its completion. Results of the study will broaden knowledge about hemispherical mechanisms of language and speech recovery after stroke and provide insight into possibilities of their modulation for the purpose of post-stroke rehabilitation.",NA,"Aphasia Stroke Theta Burst Stimulation Therapy Rehabilitation Noninvasive Transcranial Brain Stimulation","Interventional","Inclusion Criteria: First-ever left middle cerebral artery ischemic stroke (brain damage localization confirmed by magnetic resonance imaging, MRI) 3 or more months from the onset of stroke @@ -418,7 +399,7 @@ Regular intake of medication that could affect cortical excitability (e. g. anti Significant cognitive impairment limiting patient's cooperation during assessment and behavioral aphasia therapy Visual deficits significantly hindering the perception of therapeutic tasks presented visually on a computer's screen New neurological episode (e. g. another brain stroke) or somatic illness (e. g. COVID-19) during the cycle of the therapy, requiring its interruption.","No","18 Years","All","Warsaw",NA,"Masovian Voivodeship","Katarzyna Polanowska","Poland",1,"no",21.064189,52.172273,2022-09-02 -"19",16,"Efficacy of Language Games as Therapy for Post Stroke Aphasia","Stroke Aphasia","August 2015","NCT02458222","University of Birmingham Birmingham West Midlands United Kingdom","University of Birmingham","Recruiting","Aphasia is a language impairment experienced by about one third of stroke patients. This often devastating condition is treated by speech and language therapists (SLTs). There is evidence that language games delivered at the right intensity are an efficacious means of improving communication for people with post stroke aphasia. However, it is unclear which mechanism of language facilitation used in a game works best. This study will provide evidence for the ""active ingredient"" of a game, together with measures of efficacy, feasibility and enjoyment compared to standard aphasia therapy.","Aphasia is a language impairment experienced by about one third of stroke patients. This often devastating condition is treated by speech and language therapists (SLTs). There is evidence that language games delivered at the right intensity are an efficacious means of improving communication for people with post stroke aphasia. However, it is unclear which mechanism of language facilitation used in a game works best. This study will provide evidence for the ""active ingredient"" of a game, together with measures of efficacy, feasibility and enjoyment compared to standard aphasia therapy. +"18",15,"Efficacy of Language Games as Therapy for Post Stroke Aphasia","Stroke Aphasia","August 2015","NCT02458222","University of Birmingham Birmingham West Midlands United Kingdom","University of Birmingham","Recruiting","Aphasia is a language impairment experienced by about one third of stroke patients. This often devastating condition is treated by speech and language therapists (SLTs). There is evidence that language games delivered at the right intensity are an efficacious means of improving communication for people with post stroke aphasia. However, it is unclear which mechanism of language facilitation used in a game works best. This study will provide evidence for the ""active ingredient"" of a game, together with measures of efficacy, feasibility and enjoyment compared to standard aphasia therapy.","Aphasia is a language impairment experienced by about one third of stroke patients. This often devastating condition is treated by speech and language therapists (SLTs). There is evidence that language games delivered at the right intensity are an efficacious means of improving communication for people with post stroke aphasia. However, it is unclear which mechanism of language facilitation used in a game works best. This study will provide evidence for the ""active ingredient"" of a game, together with measures of efficacy, feasibility and enjoyment compared to standard aphasia therapy. Participants with moderate-severe difficulties will play picture naming games, involving self-cuing using gesture and circumlocution. Those with mild difficulties will play story-telling games, using similar self-cuing techniques. Change in language performance will be measured and compared to that achieved by the same participants following an episode of standard aphasia therapy from their local SLT (i.e. normal care). @@ -431,7 +412,7 @@ Adults who have suffered a stroke a minimum of 2 months prior to commencement of Exclusion Criteria: Severe perceptual or cognitive deficits. History of other neurological, psychiatric or neurodegenerative disease impairing language or communicative ability. Severe visual agnosia. Severe limb apraxia. Severe dysarthria. Drug or alcohol abuse.","No","18 Years","All","Birmingham","B13 8JL","West Midlands",NA,"United Kingdom",1,"no",-1.9305515,52.450079,2015-08-20 -"20",17,"Sentence Production Training in Aphasia","Aphasia","August 1, 2021","NCT05415501","Purdue University West Lafayette Indiana United States","Purdue University","Recruiting","This study focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming. First set of experiments will aim examine which priming conditions are most effective in creating maximal learning effects. Then, in a later experiment, the investigators will develop and test the efficacy of a novel treatment study based on findings from the first set of the experiments.","Over five years, the investigators will conduct a series of studies to develop a novel intervention strategy for improving sentence production and comprehension in persons with aphasia. Specifically, the investigators will use implicit priming as a novel facilitator for language recovery in aphasia. The planned studies seek to test the hypothesis that implicit priming alters the central language system in PWA, creating lasting and generalized improvements in both sentence production and comprehension. Aim 1 will determine the extent to which different manipulations of priming conditions modulate immediate and long-term improvement in sentence production. The investigators integrate multiple theories of language learning and apply them to make predictions about the trajectory of priming-induced learning in PWA. In Aim 2, using a set of eyetracking sentence comprehension tasks, it will be investigated whether the effects of priming in production generalize to off-line (accuracy) and on-line (eye fixations) sentence comprehension and determine what learning conditions result in greater cross-modality generalization. In Aim 3, the investigators will develop and establish Phase I efficacy data of an implicit priming treatment, incorporating the crucial learning conditions supporting maximal retention from Aims 1 and 2. The project will recruit both individuals with aphasia and without aphasia.","aphasia training aphasia treatment","Interventional","Inclusion Criteria: +"19",16,"Sentence Production Training in Aphasia","Aphasia","August 1, 2021","NCT05415501","Purdue University West Lafayette Indiana United States","Purdue University","Recruiting","This study focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming. First set of experiments will aim examine which priming conditions are most effective in creating maximal learning effects. Then, in a later experiment, the investigators will develop and test the efficacy of a novel treatment study based on findings from the first set of the experiments.","Over five years, the investigators will conduct a series of studies to develop a novel intervention strategy for improving sentence production and comprehension in persons with aphasia. Specifically, the investigators will use implicit priming as a novel facilitator for language recovery in aphasia. The planned studies seek to test the hypothesis that implicit priming alters the central language system in PWA, creating lasting and generalized improvements in both sentence production and comprehension. Aim 1 will determine the extent to which different manipulations of priming conditions modulate immediate and long-term improvement in sentence production. The investigators integrate multiple theories of language learning and apply them to make predictions about the trajectory of priming-induced learning in PWA. In Aim 2, using a set of eyetracking sentence comprehension tasks, it will be investigated whether the effects of priming in production generalize to off-line (accuracy) and on-line (eye fixations) sentence comprehension and determine what learning conditions result in greater cross-modality generalization. In Aim 3, the investigators will develop and establish Phase I efficacy data of an implicit priming treatment, incorporating the crucial learning conditions supporting maximal retention from Aims 1 and 2. The project will recruit both individuals with aphasia and without aphasia.","aphasia training aphasia treatment","Interventional","Inclusion Criteria: Individuals with post-stroke aphasia At least 6 months post-onset of eft hemisphere stroke @@ -446,7 +427,7 @@ Severe apraxia of speech Other neurological conditions affecting communication (e.g., dementia) Uncontrolled psychiatric/psychological conditions affecting thinking and communication Active alcohol/substance abuse","Accepts Healthy Volunteers","21 Years","All","West Lafayette","47907","Indiana","Ji Yeon Lee","United States",1,"no",-86.92597925,40.426348,2021-08-01 -"21",19,"Virtual Reality Training for Aphasia Rehabilitation","Anomic Aphasia","April 2023","NCT05793879","Catholic University of the Sacred Heart Brescia NA Italy","Catholic University of the Sacred Heart","Recruiting","Aphasia is an acquired deficit following acute damage to the central nervous system that involves the difficulty or impossibility of understanding and formulating language. A typical disorder of non-fluent forms of aphasia is anomia. Anomia refers to the difficulty in finding words, in particular when trying to name objects and actions. According to the Embodied Cognition approach (EC), language is tightly connected to the motor system. In this view, language rehabilitation programs should stimulate language through the activation of the motor system. In this approach, since anomic deficits are often due to a weak link between the meaning of the word and its lemma, the Hebbs' principles of coincident and correlated learning can be exploited, i.e., by intensifying the synchronous activation of lexicon and semantics and connecting them with the motor counterpart. In this study, the investigators present an innovative training, based on the EC framework, in which they will make use of new technologies for anomia rehabilitation in post-stroke patients. Specifically, the researchers will use immersive 360° videos representing everyday actions displayed from the first-person point of view, experienced through a head-mounted display. The training will be administered 3 times a week for 4 weeks. The control group will watch standard videos representing the same actions recorded from the third-person perspective. Naming abilities will be tested before and after the training together with other cognitive and psychological measures. The investigators expect that the group who will undergo the 360° video-based training will show greater improvement of performance compared to the control group.",NA,"virtual reality embodied cognition rehabilitation","Interventional","Inclusion Criteria: +"20",18,"Virtual Reality Training for Aphasia Rehabilitation","Anomic Aphasia","April 2023","NCT05793879","Catholic University of the Sacred Heart Brescia NA Italy","Catholic University of the Sacred Heart","Recruiting","Aphasia is an acquired deficit following acute damage to the central nervous system that involves the difficulty or impossibility of understanding and formulating language. A typical disorder of non-fluent forms of aphasia is anomia. Anomia refers to the difficulty in finding words, in particular when trying to name objects and actions. According to the Embodied Cognition approach (EC), language is tightly connected to the motor system. In this view, language rehabilitation programs should stimulate language through the activation of the motor system. In this approach, since anomic deficits are often due to a weak link between the meaning of the word and its lemma, the Hebbs' principles of coincident and correlated learning can be exploited, i.e., by intensifying the synchronous activation of lexicon and semantics and connecting them with the motor counterpart. In this study, the investigators present an innovative training, based on the EC framework, in which they will make use of new technologies for anomia rehabilitation in post-stroke patients. Specifically, the researchers will use immersive 360° videos representing everyday actions displayed from the first-person point of view, experienced through a head-mounted display. The training will be administered 3 times a week for 4 weeks. The control group will watch standard videos representing the same actions recorded from the third-person perspective. Naming abilities will be tested before and after the training together with other cognitive and psychological measures. The investigators expect that the group who will undergo the 360° video-based training will show greater improvement of performance compared to the control group.",NA,"virtual reality embodied cognition rehabilitation","Interventional","Inclusion Criteria: naming disorder in the post-acute phase (index event occurring at least 6 months earlier) to have already received rehabilitation treatment in the acute phase @@ -459,14 +440,14 @@ concomitant or pre-existing (with respect to the index event) neurological and p epilepsy balance disorders neglect","No","18 Years","All","Brescia","25123",NA,"Claudia Repetto","Italy",1,"no",139.7201515,35.651036,2023-04-20 -"22",20,"Neural Bases of Vocal Sensorimotor Impairment in Aphasia","Aphasia","July 11, 2021","NCT04742894","University of South Carolina Columbia South Carolina United States","University of South Carolina","Recruiting","Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control. While recovery can be promoted with speech therapy, improvement remains modest and typically requires a large number of sessions contributing to rising health care costs. Traditional aphasia therapy focus on enhancing speech motor output; however, recent evidence suggests that the auditory feedback also plays a critical role in fluent speech. Therefore, a key step toward refining treatment strategies is to develop objective biomarkers that can probe the integrity of sensorimotor mechanisms of speech auditory feedback and identify their impaired function in patients with post-stroke aphasia. This study aims to examine the behavioral, neurophysiological (EEG), and neuroimaging (fMRI) biomarkers of speech impairment following stroke with focus on understanding the role of auditory feedback for speech production and control. We plan to test individuals with post-stroke aphasia and a matched neuroptypical control group during different speech production tasks under the altered auditory feedback paradigm. In addition, we aim to examine the effect of audio-visual feedback training on enhancing communication ability during speech. These biomarkers will be combined with existing lesion-symptom-mapping data in the aphasic group in order to identify the patterns of brain damage and diminished structural connectivity within the auditory-motor areas of the left hemisphere that predict impaired sensorimotor processing of speech in aphasia. The long-term goal of this research is to develop a model for identifying the source of sensorimotor deficit and improve diagnosis and targeted treatment of speech disorders in aphasia.",NA,"","Interventional","Inclusion Criteria: +"21",19,"Neural Bases of Vocal Sensorimotor Impairment in Aphasia","Aphasia","July 11, 2021","NCT04742894","University of South Carolina Columbia South Carolina United States","University of South Carolina","Recruiting","Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control. While recovery can be promoted with speech therapy, improvement remains modest and typically requires a large number of sessions contributing to rising health care costs. Traditional aphasia therapy focus on enhancing speech motor output; however, recent evidence suggests that the auditory feedback also plays a critical role in fluent speech. Therefore, a key step toward refining treatment strategies is to develop objective biomarkers that can probe the integrity of sensorimotor mechanisms of speech auditory feedback and identify their impaired function in patients with post-stroke aphasia. This study aims to examine the behavioral, neurophysiological (EEG), and neuroimaging (fMRI) biomarkers of speech impairment following stroke with focus on understanding the role of auditory feedback for speech production and control. We plan to test individuals with post-stroke aphasia and a matched neuroptypical control group during different speech production tasks under the altered auditory feedback paradigm. In addition, we aim to examine the effect of audio-visual feedback training on enhancing communication ability during speech. These biomarkers will be combined with existing lesion-symptom-mapping data in the aphasic group in order to identify the patterns of brain damage and diminished structural connectivity within the auditory-motor areas of the left hemisphere that predict impaired sensorimotor processing of speech in aphasia. The long-term goal of this research is to develop a model for identifying the source of sensorimotor deficit and improve diagnosis and targeted treatment of speech disorders in aphasia.",NA,"","Interventional","Inclusion Criteria: A total of 50 individuals with aphasia due to chronic left hemisphere stroke (> 6 months post-stroke) and 50 age- and gender-matched healthy control subjects will be recruited in this study. The general inclusion criteria for all subjects include: age range 21-75 years, right-handed, and native speaker of English. The aphasic subjects have previously undergone neuro-psychological speech/language testing and have been diagnosed with one type of aphasia (e.g., Broca's, Wernicke's, conduction or anomic). Subjects in the control group will meet the inclusion criteria with having normal voice, speech, language, and hearing function and no history of neurological and psychiatric disorder. We expect that a significant proportion of aphasic patients will show symptoms associated with Apraxia of Speech (AOS) or dysarthria; however, these patients will not be excluded unless their deficits will preclude them from performing the experimental tasks. Exclusion Criteria: Subjects with moderate to severe hearing, memory, and/or cognitive impairments will be excluded for both groups. In addition, subjects with history of peripheral laryngeal disorders (e.g., paresis or vocal fold paralysis) will be excluded. Subjects will undergo safety screening and will be excluded if there are any factors counter-indicative for EEG and/or MRI scanning.","Accepts Healthy Volunteers","21 Years","All","Columbia","29208","South Carolina","Roozbeh Behroozmand","United States",1,"no",-81.026403,33.997832,2021-07-11 -"23",21,"Word Retrieval in the Wild in People With Post-Stroke Aphasia","Aphasia, Acquired","December 19, 2022","NCT05338216","Northeastern University Boston Massachusetts United States","Northeastern University","Recruiting","People with post-stroke aphasia (PWA) suffer from anomia, a condition where they know what they want to say but cannot retrieve the words. For PWA, word retrieval changes moment-to-moment, leading to diminished motivation to participate in conversations and disengagement from social interactions. In the real world, anomia variability and severity are compounded by contextual factors of communication exchanges (noise, dual-tasking). Ecological momentary assessment (EMA) involves in-situ measurement of a behavior over time during everyday life. EMA has promise for capturing real-world anomia, yet EMA methods have not been tested in PWA. Therefore, the aims of this pilot study are to (1) determine the relative feasibility of two types of smartwatch-delivered EMA (traditional-EMA and micro-EMA) in PWA and (2) determine the extent to which patient-specific factors relate to feasibility. Twenty PWA will be recruited and randomly assigned to either traditional-EMA or micro-EMA conditions. To target in-situ anomia, PWA will complete 36 picture-naming trials/day for three weeks, delivered either as a single trial 36 times per day (micro-EMA) or in four sets of nine trials/set per day (traditional-EMA). Due to the ""at-a-glance"" single trial delivery of micro-EMA, the investigators hypothesize that PWA in the micro-EMA condition will demonstrate better protocol adherence than PWA in the traditional-EMA condition. Older age, more severe cognitive-linguistic deficits, and greater discomfort with technology will be related to poorer compliance, lower completion, greater perceived burden, and lower intelligibility of naming audio recordings. This bench-to-bedside research will begin a translational path to implement EMA/micro-EMA into routine assessment of aphasia.","BACKGROUND AND TRANSLATIONAL SIGNIFICANCE Background Approximately 15 million individuals worldwide, including 795,000 Americans, suffer a new stroke each year. Aphasia, a disorder characterized by receptive and/or expressive language deficits, affects approximately 30% of stroke survivors and is one of the most devastating post-stroke conditions. Aphasia is a heterogenous disorder, yet anomia (i.e., impaired word retrieval) is a persistent, ubiquitous impairment present in all people with aphasia (PWA). Neurotypical individuals occasionally experience anomia during ""tip-of-the-tongue"" moments: frustrating instances when someone knows what they want to say but the word itself eludes them. For the two million Americans currently living with aphasia, word retrieval difficulties are far more severe and pervade all communication attempts. Anomia severity ranges between PWA, from mild difficulties such as delayed retrieval of low frequency words (e.g., amulet) to severe difficulty retrieving the names of even common objects (e.g., bed). Yet, regardless of severity, a hallmark of post-stroke anomia is inconsistent word retrieval across attempts for a given word. For PWA, the ability to access words can change day-to-day and even minute-to-minute, resulting in diminished motivation to participate in conversations, disengagement from social interactions, and reduced quality of life. +"22",20,"Word Retrieval in the Wild in People With Post-Stroke Aphasia","Aphasia, Acquired","December 19, 2022","NCT05338216","Northeastern University Boston Massachusetts United States","Northeastern University","Recruiting","People with post-stroke aphasia (PWA) suffer from anomia, a condition where they know what they want to say but cannot retrieve the words. For PWA, word retrieval changes moment-to-moment, leading to diminished motivation to participate in conversations and disengagement from social interactions. In the real world, anomia variability and severity are compounded by contextual factors of communication exchanges (noise, dual-tasking). Ecological momentary assessment (EMA) involves in-situ measurement of a behavior over time during everyday life. EMA has promise for capturing real-world anomia, yet EMA methods have not been tested in PWA. Therefore, the aims of this pilot study are to (1) determine the relative feasibility of two types of smartwatch-delivered EMA (traditional-EMA and micro-EMA) in PWA and (2) determine the extent to which patient-specific factors relate to feasibility. Twenty PWA will be recruited and randomly assigned to either traditional-EMA or micro-EMA conditions. To target in-situ anomia, PWA will complete 36 picture-naming trials/day for three weeks, delivered either as a single trial 36 times per day (micro-EMA) or in four sets of nine trials/set per day (traditional-EMA). Due to the ""at-a-glance"" single trial delivery of micro-EMA, the investigators hypothesize that PWA in the micro-EMA condition will demonstrate better protocol adherence than PWA in the traditional-EMA condition. Older age, more severe cognitive-linguistic deficits, and greater discomfort with technology will be related to poorer compliance, lower completion, greater perceived burden, and lower intelligibility of naming audio recordings. This bench-to-bedside research will begin a translational path to implement EMA/micro-EMA into routine assessment of aphasia.","BACKGROUND AND TRANSLATIONAL SIGNIFICANCE Background Approximately 15 million individuals worldwide, including 795,000 Americans, suffer a new stroke each year. Aphasia, a disorder characterized by receptive and/or expressive language deficits, affects approximately 30% of stroke survivors and is one of the most devastating post-stroke conditions. Aphasia is a heterogenous disorder, yet anomia (i.e., impaired word retrieval) is a persistent, ubiquitous impairment present in all people with aphasia (PWA). Neurotypical individuals occasionally experience anomia during ""tip-of-the-tongue"" moments: frustrating instances when someone knows what they want to say but the word itself eludes them. For the two million Americans currently living with aphasia, word retrieval difficulties are far more severe and pervade all communication attempts. Anomia severity ranges between PWA, from mild difficulties such as delayed retrieval of low frequency words (e.g., amulet) to severe difficulty retrieving the names of even common objects (e.g., bed). Yet, regardless of severity, a hallmark of post-stroke anomia is inconsistent word retrieval across attempts for a given word. For PWA, the ability to access words can change day-to-day and even minute-to-minute, resulting in diminished motivation to participate in conversations, disengagement from social interactions, and reduced quality of life. Per psycholinguistic models of lexical access, naming is a two-step process that involves retrieval of the target's meaning from the semantic system and word form (speech sounds) from the phonological system. Naming failures in PWA result in errors that are related to a target word in meaning (e.g., ""carrot"" for bean), word form (e.g., ""fean"" for bean), both meaning and form (e.g., ""green"" for bean), or neither (e.g., ""pencil"" for bean; ""I know it but I can't say it"" for bean) due to insufficient activation of the target meaning/form representations or overactivation of incorrect representations. Due to this noisy system, lexical access is often delayed in PWA, even when the correct word is eventually retrieved. Naming accuracy, response times, and error types provide meaningful information regarding the locus of naming impairment and a patient's recovery capacity. The investigators found that the number of phonological and unrelated errors produced during early post-stroke stages predicted longitudinal changes in naming and global language skills in left hemisphere stroke survivors. Naming errors and the integrity of underlying semantic and phonological systems can also guide language treatment planning. As such, accurate assessment of naming is critical for aphasia care. @@ -527,7 +508,7 @@ Presence of aphasia Exclusion Criteria: History of neurological disease affecting the brain other than stroke","No","18 Years","All","Boston","02115","Massachusetts",NA,"United States",1,"no",-71.0883555,42.3397355,2022-12-19 -"24",22,"Semantic Feature Analysis Treatment for Aphasia","Aphasia","February 24, 2020","NCT04215952","VA Pittsburgh Healthcare System Pittsburgh Pennsylvania United States","VA Pittsburgh Healthcare System","Recruiting","This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of treatment success. Study participants will be randomly assigned to one of two treatment conditions comparing two different versions of Semantic Feature Analysis treatment. Their performance on standardized and study-specific measures will be used to determine which version of the treatment provides superior outcomes, and measures of automatic language processing and functional brain imaging will also be used to identify the underlying neurocognitive mechanisms associated with positive treatment response.","This randomized comparative effectiveness trial examines whether active manipulation of a key component of semantic feature analysis (SFA) treatment for word-finding difficulty in aphasia improves outcomes. 40 study participants will be recruited and randomized to receive one of the two versions of the treatment. The total treatment time will be equated in the two conditions. +"23",21,"Semantic Feature Analysis Treatment for Aphasia","Aphasia","February 24, 2020","NCT04215952","VA Pittsburgh Healthcare System Pittsburgh Pennsylvania United States","VA Pittsburgh Healthcare System","Recruiting","This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of treatment success. Study participants will be randomly assigned to one of two treatment conditions comparing two different versions of Semantic Feature Analysis treatment. Their performance on standardized and study-specific measures will be used to determine which version of the treatment provides superior outcomes, and measures of automatic language processing and functional brain imaging will also be used to identify the underlying neurocognitive mechanisms associated with positive treatment response.","This randomized comparative effectiveness trial examines whether active manipulation of a key component of semantic feature analysis (SFA) treatment for word-finding difficulty in aphasia improves outcomes. 40 study participants will be recruited and randomized to receive one of the two versions of the treatment. The total treatment time will be equated in the two conditions. Study participants will be housed locally at the Pittsburgh site at no cost and will be eligible to receive reimbursement for travel expenses. During the five-week treatment phase of the study, participants will receive 60 hours of SFA treatment with pre- and post-treatment assessment of their ability to name pictures of treated and untreated, semantically related nouns. Other secondary outcomes, including measures of connected speech and patient-reported communication ability will also be collected. In order to address unresolved questions about the underlying cognitive and neural mechanisms of SFA, participants will also receive concurrent pre- and post-treatment assessment of automatic word processing ability using eye-tracking methods and functional magnetic resonance imaging (fMRI). Participants will also be asked to return to Pittsburgh for two days approximately 2-3 months later for follow-up language, eye-tracking, and fMRI testing. @@ -548,7 +529,7 @@ Neurological disease other than stroke Significant psychiatric disorder Severe motor speech disorder Active substance dependence","No","18 Years","All","Pittsburgh","15240","Pennsylvania",NA,"United States",1,"no",-79.961502,40.446625,2020-02-24 -"25",24,"Theory-Driven Treatment of Language and Cognitive Processes in Aphasia","Aphasia","March 2014","NCT02664506","Temple University Philadelphia Pennsylvania United States","Temple University","Recruiting","The aim of this research is to translate a theory of the cognitive relationship between verbal short--term memory (STM) and word processing impairments in aphasia to treatment approaches for language impairment in aphasia. It has been proposed that the co-occurrence of these impairments is due to a disruption of cognitive processes that support both abilities: maintenance of activated semantic and phonological representations of words, hereafter the 'activation--maintenance hypothesis'. +"24",23,"Theory-Driven Treatment of Language and Cognitive Processes in Aphasia","Aphasia","March 2014","NCT02664506","Temple University Philadelphia Pennsylvania United States","Temple University","Recruiting","The aim of this research is to translate a theory of the cognitive relationship between verbal short--term memory (STM) and word processing impairments in aphasia to treatment approaches for language impairment in aphasia. It has been proposed that the co-occurrence of these impairments is due to a disruption of cognitive processes that support both abilities: maintenance of activated semantic and phonological representations of words, hereafter the 'activation--maintenance hypothesis'. This hypothesis will be tested in the context of a treatment approach that aims to improve word processing and verbal STM abilities.","Based on research of word processing and verbal STM impairments in aphasia, it has been proposed that the co-occurrence of these impairments is due to a disruption of cognitive processes that support both abilities: maintenance of activated semantic and phonological representations of words, hereafter the 'activation--maintenance hypothesis'. @@ -588,7 +569,7 @@ Exclusion Criteria: History of neurological disease or language disability Histories for mental illness Alcohol/substance abuse.","Accepts Healthy Volunteers","21 Years","All","Philadelphia","19121","Pennsylvania","Nadine Martin","United States",1,"no",-75.155202,39.9808005,2014-03-20 -"26",25,"Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia","Aphasia","March 28, 2019","NCT03651700","University of Pennsylvania Philadelphia Pennsylvania United States","University of Pennsylvania","Recruiting","Transcranial Magnetic Stimulation (TMS) has been demonstrated to improve language function in subjects with chronic aphasia in a number of small studies, many of which did not include a control group. Although the treatment appears promising, data to date do not permit an adequate assessment of the utility of the technique. The investigators propose to study the effects of TMS combined with Constraint Induced Language Therapy (CILT) in 75 subjects with chronic aphasia. Subjects will be randomized in a 2:1 ratio to TMS with CILT or sham TMS with CILT. One Hz TMS at 90% motor threshold will be delivered to the right inferior frontal gyrus for 20 minutes in 10 sessions over 2 weeks; language therapy will be provided for one hour immediately after the conclusion of each session of TMS. Change from baseline in the Western Aphasia Battery Aphasia Quotient at 6 months after the end of TMS treatment will serve as the primary outcome measure. A secondary aim is to identify anatomic and behavioral predictors of response to treatment. Finally, a third aim is to identify the mechanism underlying the beneficial effect of the treatment using a variety of imaging techniques. Subjects who have no contraindication to the MRI will undergo fMRI imaging prior to and at 6 months after therapy. Using modern network analyses and robust machine learning techniques, the investigators will identify changes in the strengths of connections between nodes in the language network to address specific hypotheses regarding the effects of TMS and CILT on brain organization that are associated with beneficial response to treatment.","TMS is a technique by which a brief electrical current is induced in brain tissue causing a brief suppression of the excitability of the underlying tissue; the technique, which was introduced in the 1980s and has been extensively used around the world, has been shown to transiently improve or disrupt specific cognitive operations. To achieve this end, a coil is positioned against the subject's head. The delivery of a single pulse begins with the discharge of current from a capacitor into a circular or figure-of-eight coil; this electrical current generates a brief magnetic field of up to 2.2 Tesla. As the pulse of electricity has a rise time of 0.2 ms. and a duration of 1 ms., the magnetic field changes in intensity quite rapidly. Because the magnetic field passes freely through the scalp, skull, and meninges, the flux in the magnetic field induces a small electric field in the brain that transiently alters neural activity. +"25",24,"Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia","Aphasia","March 28, 2019","NCT03651700","University of Pennsylvania Philadelphia Pennsylvania United States","University of Pennsylvania","Recruiting","Transcranial Magnetic Stimulation (TMS) has been demonstrated to improve language function in subjects with chronic aphasia in a number of small studies, many of which did not include a control group. Although the treatment appears promising, data to date do not permit an adequate assessment of the utility of the technique. The investigators propose to study the effects of TMS combined with Constraint Induced Language Therapy (CILT) in 75 subjects with chronic aphasia. Subjects will be randomized in a 2:1 ratio to TMS with CILT or sham TMS with CILT. One Hz TMS at 90% motor threshold will be delivered to the right inferior frontal gyrus for 20 minutes in 10 sessions over 2 weeks; language therapy will be provided for one hour immediately after the conclusion of each session of TMS. Change from baseline in the Western Aphasia Battery Aphasia Quotient at 6 months after the end of TMS treatment will serve as the primary outcome measure. A secondary aim is to identify anatomic and behavioral predictors of response to treatment. Finally, a third aim is to identify the mechanism underlying the beneficial effect of the treatment using a variety of imaging techniques. Subjects who have no contraindication to the MRI will undergo fMRI imaging prior to and at 6 months after therapy. Using modern network analyses and robust machine learning techniques, the investigators will identify changes in the strengths of connections between nodes in the language network to address specific hypotheses regarding the effects of TMS and CILT on brain organization that are associated with beneficial response to treatment.","TMS is a technique by which a brief electrical current is induced in brain tissue causing a brief suppression of the excitability of the underlying tissue; the technique, which was introduced in the 1980s and has been extensively used around the world, has been shown to transiently improve or disrupt specific cognitive operations. To achieve this end, a coil is positioned against the subject's head. The delivery of a single pulse begins with the discharge of current from a capacitor into a circular or figure-of-eight coil; this electrical current generates a brief magnetic field of up to 2.2 Tesla. As the pulse of electricity has a rise time of 0.2 ms. and a duration of 1 ms., the magnetic field changes in intensity quite rapidly. Because the magnetic field passes freely through the scalp, skull, and meninges, the flux in the magnetic field induces a small electric field in the brain that transiently alters neural activity. TMS may be delivered in a variety of ways. The investigators propose to use 1 Hz TMS; that is, TMS pulses will be delivered at a frequency of 1/second. This style of TMS is assumed to be inhibitory in that it transiently suppresses the function of the cortex under the coil. Using the figure-of-eight coil to be employed here, TMS is thought to reduce activity in approximately 1 cubic cm. of cortex. Many investigators have employed TMS with a frequency of 1 Hz for periods of 20 minutes and longer; mild behavioral deficits are often present for several minutes in these studies. @@ -612,7 +593,7 @@ Previous head trauma with loss of consciousness for more than 5 minutes Psychiatric illness (We note that subjects will be assessed with the 15-item Geriatric Depression scale. Because depression is very difficult to evaluate in aphasic subjects, potential subjects will not be excluded on the basis of the depression score) Chronic exposure to medications that might be expected to have lasting consequences for the central nervous system (e.g. haloperidol, dopaminergics) History of or neuropsychological findings suggestive of dementia","No","18 Years","All","Philadelphia","19104","Pennsylvania","H. Branch Coslett","United States",1,"no",-75.1940565,39.9529705,2019-03-28 -"27",26,"Efficacy of a Combined Linguistic/Communication Therapy in Acute Aphasia After Stroke","Aphasia, Acquired","March 1, 2018","NCT03287544","University Hospital, Toulouse Toulouse Midi-Pyrénées France","University Hospital, Toulouse","Recruiting","Linguistic training is traditionally the gold standard for rehabilitation of aphasia after stroke and efficacy criteria count early stage, intensity as well as personalized treatment. To date, no clear evidence showed a specific effect of any therapy in the acute phase of aphasia after stroke. This study aims to compare the effect of a combined therapy (linguistic/communication) versus a linguistic therapy on communication performance in patients in the acute phase of aphasia after a first stroke.","Twenty to 25% of strokes cause aphasia. Speech and language therapy is the well-known standard treatment of aphasia after stroke although it is based on weak scientific evidence. To date, the efficacy criteria of aphasia rehabilitation are early stage, intensity as well as personalized treatment. Usually these patients receive in acute phase a linguistic training focused on the linguistic impairment. This approach is based on the cerebral plasticity postulate. However the superiority of this practice compared to other methods has never been shown. Moreover the benefit of the combination gathering linguistic treatment with communication treatment has to our knowledge never been studied. +"26",25,"Efficacy of a Combined Linguistic/Communication Therapy in Acute Aphasia After Stroke","Aphasia, Acquired","March 1, 2018","NCT03287544","University Hospital, Toulouse Toulouse Midi-Pyrénées France","University Hospital, Toulouse","Recruiting","Linguistic training is traditionally the gold standard for rehabilitation of aphasia after stroke and efficacy criteria count early stage, intensity as well as personalized treatment. To date, no clear evidence showed a specific effect of any therapy in the acute phase of aphasia after stroke. This study aims to compare the effect of a combined therapy (linguistic/communication) versus a linguistic therapy on communication performance in patients in the acute phase of aphasia after a first stroke.","Twenty to 25% of strokes cause aphasia. Speech and language therapy is the well-known standard treatment of aphasia after stroke although it is based on weak scientific evidence. To date, the efficacy criteria of aphasia rehabilitation are early stage, intensity as well as personalized treatment. Usually these patients receive in acute phase a linguistic training focused on the linguistic impairment. This approach is based on the cerebral plasticity postulate. However the superiority of this practice compared to other methods has never been shown. Moreover the benefit of the combination gathering linguistic treatment with communication treatment has to our knowledge never been studied. In the present study investigators propose to compare the effect of a combined linguistic/communication rehabilitation versus a linguistic treatment. To do so, investigators will recruit patients with aphasia after a first stroke, in the acute phase. After a allocation to the "" combined "" and "" linguistic "" groups, all the patients will have a comprehensive language and neuropsychological assessment before and after 3 months of rehabilitation, and finally 6 months after the onset. @@ -634,7 +615,7 @@ Uncorrected sensory impairment Evolutive pathology Adults protected by Law Participation to another research","No","18 Years","All","Toulouse","31059","Midi-Pyrénées",NA,"France",1,"no",1.444247,43.604462,2018-03-01 -"28",27,"Effects of rTMS Based on Hemodynamic Activity for Language Recovery in Early Poststroke Aphasia","Stroke Aphasia","November 2015","NCT02591719","Seoul National University Bundang Hospital Seongnam-si Korea, Gyeonggi-do Korea, Republic of","Seoul National University Bundang Hospital","Recruiting","The aim of this study is to assess the safety and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) based on hemodynamic brain activity pattern with functional near infrared spectroscopy (fNIRS) in early poststroke nonfluent aphasia patients.","Most conventional rTMS studies employed an inhibitory low frequency protocol for the contralesional homologs of Broca's area. +"27",26,"Effects of rTMS Based on Hemodynamic Activity for Language Recovery in Early Poststroke Aphasia","Stroke Aphasia","November 2015","NCT02591719","Seoul National University Bundang Hospital Seongnam-si Korea, Gyeonggi-do Korea, Republic of","Seoul National University Bundang Hospital","Recruiting","The aim of this study is to assess the safety and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) based on hemodynamic brain activity pattern with functional near infrared spectroscopy (fNIRS) in early poststroke nonfluent aphasia patients.","Most conventional rTMS studies employed an inhibitory low frequency protocol for the contralesional homologs of Broca's area. In the present randomized controlled trial, investigators will perform fNIRS prior to rTMS treatment to select the stimulation method. Stimulation site (perilesional or contralesional) and frequency (excitatory high or inhibitory low) will be determined by activation pattern from the fNIRS with language task in individual patients. @@ -658,7 +639,7 @@ Severe cognitive impairment (MMSE less than 16) Skin lesion in the stimulation site of scalp Metal implants in the body (cardiac pacemaker or aneurysm clip) Pregnancy, breastfeeding","No","18 Years","All","Seongnam-si","463-707","Korea, Gyeonggi-do","Nam-Jong Paik","Korea, Republic of",1,"no",127.1232505,37.351887,2015-11-20 -"29",28,"Neuro Device for Aphasia","Post-stroke Aphasia","August 2023","NCT05194566","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.","There are about 15 million strokes worldwide each year. Of this group, about 30% suffer from aphasia. Aphasia is a speech-language disorder associated with exceptional difficulty performing daily communication activities. If no improvement is observed within the first months after the stroke, a complete recovery is unlikely, and the therapy can last for years. +"28",27,"Neuro Device for Aphasia","Post-stroke Aphasia","August 2023","NCT05194566","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.","There are about 15 million strokes worldwide each year. Of this group, about 30% suffer from aphasia. Aphasia is a speech-language disorder associated with exceptional difficulty performing daily communication activities. If no improvement is observed within the first months after the stroke, a complete recovery is unlikely, and the therapy can last for years. Up to date, speech and language therapy is a standard of care for post-stroke aphasia, however the process is long and demanding. @@ -705,7 +686,7 @@ Withdrawal criteria: high intolerance to stimulation (participants experience severe discomfort during stimulation); occurrence of an epileptic seizure; other previously absent neurological, physical or mental symptoms.","No","18 Years","All","New York","10029","New York","Miguel Escalon","United States",1,"no",-73.953275,40.7898205,2023-08-20 -"30",29,"Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.","Stroke Aphasia","October 18, 2022","NCT04432883","University of New Mexico Albuquerque New Mexico United States","University of New Mexico","Recruiting","62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.","Our long-term goal is to develop safe and effective treatments for the communication problems of Aphasia due to stroke that restore patients to higher levels of functioning, decrease disability, and promote higher quality of life. While language therapy for aphasia is effective, improvements are typically slow, and gains may be small. Noninvasive brain stimulation has been suggested as a method to enhance outcomes from language therapy. This study will examine whether outcomes for language therapy with brain stimulation are different from outcomes for language therapy without brain stimulation in people with aphasia. Our central hypotheses are (1) targeted right hemisphere HDtDCS (RH-HD-tDCS) administered in combination with language treatment will result in greater changes in naming accuracy than language treatment with the sham RH-HD-tDCS (2) RH-HD-tDCS plus language treatment will result in greater increases in communication within the affected hemisphere compared to language treatment plus sham RH-HD-tDCS (3) RH-HD-tDCS plus language treatment will result in greater increases in perilesional areas working together immediately post-treatment compared to language treatment plus sham RH-HD-tDCS","Stroke Aphasia brain stimulation communication problems speech and language therapy","Interventional","Inclusion Criteria: +"29",28,"Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.","Stroke Aphasia","October 18, 2022","NCT04432883","University of New Mexico Albuquerque New Mexico United States","University of New Mexico","Recruiting","62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.","Our long-term goal is to develop safe and effective treatments for the communication problems of Aphasia due to stroke that restore patients to higher levels of functioning, decrease disability, and promote higher quality of life. While language therapy for aphasia is effective, improvements are typically slow, and gains may be small. Noninvasive brain stimulation has been suggested as a method to enhance outcomes from language therapy. This study will examine whether outcomes for language therapy with brain stimulation are different from outcomes for language therapy without brain stimulation in people with aphasia. Our central hypotheses are (1) targeted right hemisphere HDtDCS (RH-HD-tDCS) administered in combination with language treatment will result in greater changes in naming accuracy than language treatment with the sham RH-HD-tDCS (2) RH-HD-tDCS plus language treatment will result in greater increases in communication within the affected hemisphere compared to language treatment plus sham RH-HD-tDCS (3) RH-HD-tDCS plus language treatment will result in greater increases in perilesional areas working together immediately post-treatment compared to language treatment plus sham RH-HD-tDCS","Stroke Aphasia brain stimulation communication problems speech and language therapy","Interventional","Inclusion Criteria: aged 25-85 must be greater than 1 year post-stroke @@ -722,7 +703,7 @@ substance/alcohol dependence or abuse within the past year presence of any implanted electrical device or contraindications to tDCS or MRI recent medical instability (within 4 weeks) pregnancy","No","25 Years","All","Albuquerque","87106","New Mexico","Jessica Richardson","United States",1,"no",-106.6208755,35.083292,2022-10-18 -"31",30,"Studying Language With Brain Stimulation in Aphasia","Stroke Aphasia","January 9, 2023","NCT05660304","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The overall goal of this study is to evaluate whether stimulation of two brain areas alongside behavioral speech-language therapy increases connectivity to improve language functions in stroke-aphasia patients.","The brain is made up of networks that communicate with each other to help us think and communicate. After a stroke, networks between different areas of the brain can lose connection. In the case of aphasia, networks in the language areas of the brain are often disrupted. There is currently no ""fix"" to restore these specific language connections. However, transcranial magnetic stimulation (TMS) might help the areas reconnect through alternative pathways. +"30",29,"Studying Language With Brain Stimulation in Aphasia","Stroke Aphasia","January 9, 2023","NCT05660304","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The overall goal of this study is to evaluate whether stimulation of two brain areas alongside behavioral speech-language therapy increases connectivity to improve language functions in stroke-aphasia patients.","The brain is made up of networks that communicate with each other to help us think and communicate. After a stroke, networks between different areas of the brain can lose connection. In the case of aphasia, networks in the language areas of the brain are often disrupted. There is currently no ""fix"" to restore these specific language connections. However, transcranial magnetic stimulation (TMS) might help the areas reconnect through alternative pathways. TMS is a non-invasive procedure (in other words, it takes place outside your body). A coil will be placed over your head. The coil sends magnetic pulses to your brain to stimulate, or excite, neurons. Most studies using TMS stimulate one area of the brain at a time, but this does not tell us how to improve the network connections between brain areas. @@ -754,7 +735,7 @@ Ménière's disease Medications that increase risk of seizures, for instance antipsychotic and antidepressant medications acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants Non-prescribed drug use, for instance recreational marijuana Unable to refrain from using any alcohol and nicotine products for at least 24 hours before the study Visits.","No","18 Years","All","Chicago","60611","Illinois","Julio C Hernandez Pavon","United States",1,"no",-87.618428,41.893889,2023-01-09 -"32",31,"Genetic and Cognitive Predictors of Aphasia Treatment Response","Aphasia","October 23, 2020","NCT05179538","Ohio State University Columbus Ohio United States","Ohio State University","Recruiting","Aphasia, or language impairment after a stroke, affects approximately 2 million people in the United States, with an estimated 180,000 new cases each year. The medical community cannot predict how well someone with aphasia will respond to treatment, as some people with aphasia are poor responders to intervention even when participating in empirically supported treatments. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. This study will investigate whether two genes and cognitive abilities, such as memory, predict responsiveness to aphasia therapy for word-retrieval difficulties.","Incomplete understanding of patient-specific factors that determine whether someone will respond well to language therapy after stroke limits the development of methods to target or account for sources of variability. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. The long-term goal of this line of work is to maximize response to aphasia therapy by incorporating patient-specific factors into decisions related to treatment planning. The overall objective of this application is to identify patterns of patient-specific factors including two candidate genes and cognitive skills that show a relationship with treatment outcomes. The central hypothesis is that there will be a relationship between ApoE and BDNF genotypes, and working memory on stimulus generalization. The rationale for the proposed project is that the identification of factors that impact treatment responsiveness will allow for better estimation of prognosis, improved triage of individuals into appropriate therapy regimens and direct targeting of cognitive factors to maximize behavioral gains. The two specific aims of the project are to determine the degree to which (1) ApoE and BDNF genotypes influence how individuals with aphasia respond to therapy, and (2) working memory abilities are related to stimulus acquisition and stimulus generalization after anomia therapy. Individuals with chronic post-stroke aphasia will undergo cognitive and language assessment, and provide a saliva sample for genetic analysis prior to participating in a cued picture-naming therapy for anomia. The expected outcomes are to integrate cognitive scores and genotypes for BDNF and ApoE into formulating probabilities of individual patient responsiveness to restorative therapy. Improvement in word retrieval abilities will be evaluated using the percentage of pictures named correctly. This contribution is expected to be significant because it will allow for more informed clinical decision making and better allocation of resources to appropriate treatments, thereby making advances in the field toward more personalized medicine, as opposed to a one-size-fits-all clinical approach. +"31",30,"Genetic and Cognitive Predictors of Aphasia Treatment Response","Aphasia","October 23, 2020","NCT05179538","Ohio State University Columbus Ohio United States","Ohio State University","Recruiting","Aphasia, or language impairment after a stroke, affects approximately 2 million people in the United States, with an estimated 180,000 new cases each year. The medical community cannot predict how well someone with aphasia will respond to treatment, as some people with aphasia are poor responders to intervention even when participating in empirically supported treatments. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. This study will investigate whether two genes and cognitive abilities, such as memory, predict responsiveness to aphasia therapy for word-retrieval difficulties.","Incomplete understanding of patient-specific factors that determine whether someone will respond well to language therapy after stroke limits the development of methods to target or account for sources of variability. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. The long-term goal of this line of work is to maximize response to aphasia therapy by incorporating patient-specific factors into decisions related to treatment planning. The overall objective of this application is to identify patterns of patient-specific factors including two candidate genes and cognitive skills that show a relationship with treatment outcomes. The central hypothesis is that there will be a relationship between ApoE and BDNF genotypes, and working memory on stimulus generalization. The rationale for the proposed project is that the identification of factors that impact treatment responsiveness will allow for better estimation of prognosis, improved triage of individuals into appropriate therapy regimens and direct targeting of cognitive factors to maximize behavioral gains. The two specific aims of the project are to determine the degree to which (1) ApoE and BDNF genotypes influence how individuals with aphasia respond to therapy, and (2) working memory abilities are related to stimulus acquisition and stimulus generalization after anomia therapy. Individuals with chronic post-stroke aphasia will undergo cognitive and language assessment, and provide a saliva sample for genetic analysis prior to participating in a cued picture-naming therapy for anomia. The expected outcomes are to integrate cognitive scores and genotypes for BDNF and ApoE into formulating probabilities of individual patient responsiveness to restorative therapy. Improvement in word retrieval abilities will be evaluated using the percentage of pictures named correctly. This contribution is expected to be significant because it will allow for more informed clinical decision making and better allocation of resources to appropriate treatments, thereby making advances in the field toward more personalized medicine, as opposed to a one-size-fits-all clinical approach. The investigators will determine genotypes for BDNF and ApoE, which will yield four separate groups. At least 20 participants will be enrolled for each genotype group.","","Interventional","Inclusion Criteria: @@ -771,7 +752,7 @@ Severe depression. Diffuse injury or disease of the brain Uncorrected vision or hearing difficulties Contraindications for MRI (e.g. cardiac pacemaker, ferrous metal implants, claustrophobia, pregnancy).","No","18 Years","All","Columbus","43210","Ohio",NA,"United States",1,"no",-83.0122685,40.0010725,2020-10-23 -"33",33,"Stepped Care for Aphasia","Aphasia Stroke","March 31, 2023","NCT05851573","Medical University of South Carolina Charleston South Carolina United States","Medical University of South Carolina","Recruiting","This study is recruiting people who had a stroke at least 1 month ago and now have a language impairment called aphasia. Living with aphasia can have devastating effects on communication and quality of life, and it is not uncommon for survivors with aphasia to face psychological problems like depression and anxiety. Participants who are eligible for this study will undergo baseline testing, engage in a 5-week treatment focused on psychological well-being, undergo post-treatment testing, and then testing again 1-month later. Check-in phone calls will be conducted during the 1-month off period and participants will be interviewed about their experience at the end of the study as well. Compensation will be provided to participants with aphasia.",NA,"","Interventional","Inclusion Criteria: +"32",32,"Stepped Care for Aphasia","Aphasia Stroke","March 31, 2023","NCT05851573","Medical University of South Carolina Charleston South Carolina United States","Medical University of South Carolina","Recruiting","This study is recruiting people who had a stroke at least 1 month ago and now have a language impairment called aphasia. Living with aphasia can have devastating effects on communication and quality of life, and it is not uncommon for survivors with aphasia to face psychological problems like depression and anxiety. Participants who are eligible for this study will undergo baseline testing, engage in a 5-week treatment focused on psychological well-being, undergo post-treatment testing, and then testing again 1-month later. Check-in phone calls will be conducted during the 1-month off period and participants will be interviewed about their experience at the end of the study as well. Compensation will be provided to participants with aphasia.",NA,"","Interventional","Inclusion Criteria: 18-81 years old Native English speaker (English fluency by age 7) @@ -787,7 +768,7 @@ Uncorrected hearing or visual impairment that prevents completion of experimenta History of other neurological disorder or disease beside stroke (e.g., dementia, traumatic brain injury) as determined by self-report and/or medical records Self-reported history of premorbid learning disability Severe auditory comprehension deficits (as indicated by a score of more than two standard deviations below norms on the Auditory Verbal section of WAB-R)","No","18 Years","All","Charleston","29425","South Carolina","Deena Blackett","United States",1,"no",-79.947297,32.784808,2023-03-31 -"34",34,"Modulating Intensity and Dosage of Aphasia Scripts","Aphasia","September 21, 2020","NCT04138940","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The purpose of this study is to evaluate how changing conditions of speech-language treatment (namely, amount of repetition and distribution of practice schedule) affects the language outcome of participants with aphasia following a stroke. Using a computer based speech and language therapy program, participants will practice conversational scripts that are either short or long. Participants will practice for either 2 weeks (5 days a week) or for 5 weeks (2 days a week).","Determining the optimal intensity of treatment is essential to the design and implementation of any treatment program for aphasia. Yet, treatment intensity is a complex construct and information on the variables modulating it remain ambiguous and limited. Studies reported in the neuroscience and clinical literature support the need for intensive treatment to induce long-term neuroplastic changes while the cognitive psychology literature suggests that learning is best maintained with distributed schedules. A few studies have looked at dose parameters for single word naming tasks, but there is limited evidence regarding dose parameters for treatments that focus on training the production of larger units, such as sentences or even connected discourse. One approach that is frequently used clinically and has evidence for its efficacy is script training. Little is currently known regarding the optimum dose of script training (i.e., the number of repetitions over time of each sentence within the script) that is required to promote the best outcomes. +"33",33,"Modulating Intensity and Dosage of Aphasia Scripts","Aphasia","September 21, 2020","NCT04138940","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The purpose of this study is to evaluate how changing conditions of speech-language treatment (namely, amount of repetition and distribution of practice schedule) affects the language outcome of participants with aphasia following a stroke. Using a computer based speech and language therapy program, participants will practice conversational scripts that are either short or long. Participants will practice for either 2 weeks (5 days a week) or for 5 weeks (2 days a week).","Determining the optimal intensity of treatment is essential to the design and implementation of any treatment program for aphasia. Yet, treatment intensity is a complex construct and information on the variables modulating it remain ambiguous and limited. Studies reported in the neuroscience and clinical literature support the need for intensive treatment to induce long-term neuroplastic changes while the cognitive psychology literature suggests that learning is best maintained with distributed schedules. A few studies have looked at dose parameters for single word naming tasks, but there is limited evidence regarding dose parameters for treatments that focus on training the production of larger units, such as sentences or even connected discourse. One approach that is frequently used clinically and has evidence for its efficacy is script training. Little is currently known regarding the optimum dose of script training (i.e., the number of repetitions over time of each sentence within the script) that is required to promote the best outcomes. This study investigates the effects of modulating stimulus variables, specifically stimulus practice distribution and stimulus repetition. We use a baseline script treatment that has experimental support regarding its efficacy, and that allows the manipulation of these variables. To ensure independence and fidelity, treatment is provided in a controlled computer environment (desktop and tablet). To avoid clinician-related variables such as expertise and personality factors that may influence treatment, sentences are modeled during treatment by an anthropomorphic agent with high visual speech intelligibility and affective expressions. @@ -810,7 +791,7 @@ Exclusion Criteria: Any other neurological condition (other than cerebral vascular disease) that could potentially affect cognition or speech, such as Parkinson's Disease, Alzheimer's Dementia, traumatic brain injury Any significant psychiatric history prior to the stroke, such as severe major depression or psychotic disorder requiring hospitalization; subjects with mood disorders who are currently stable on treatment will be considered Active substance abuse","No","21 Years","All","Chicago","60611","Illinois","Leora Cherney","United States",1,"no",-87.618428,41.893889,2020-09-21 -"35",35,"High Definition Transcranial Alternating Current Stimulation (HD-tACS) for Post-stroke Aphasia","Transcranial Alternating Current Stimulation Post-stroke Aphasia Functional Magnetic Resonance Imaging","March 18, 2021","NCT05502822","Anhui Medical University Hefei NA China","Anhui Medical University","Recruiting","To investigate the intervention effect of high definition transcranial alternating current stimulation(HD-tACS) in chronic post-stroke aphasia and its underlying neural mechanism by MRI.","Aphasia is one of the most frequent cognitive deficits in poststroke survivor. More than 20% of stroke patients suffered from language impairment. The recovery of language dysfunction after stroke is highly variable. Some patients recover spontaneously in the early phases of stroke, but about two thirds of patients never fully restore language ability. The purpose of this study was to explore the intervention effect of high definition transcranial alternating current stimulation in chronic post-stroke aphasia. +"34",34,"High Definition Transcranial Alternating Current Stimulation (HD-tACS) for Post-stroke Aphasia","Transcranial Alternating Current Stimulation Post-stroke Aphasia Functional Magnetic Resonance Imaging","March 18, 2021","NCT05502822","Anhui Medical University Hefei NA China","Anhui Medical University","Recruiting","To investigate the intervention effect of high definition transcranial alternating current stimulation(HD-tACS) in chronic post-stroke aphasia and its underlying neural mechanism by MRI.","Aphasia is one of the most frequent cognitive deficits in poststroke survivor. More than 20% of stroke patients suffered from language impairment. The recovery of language dysfunction after stroke is highly variable. Some patients recover spontaneously in the early phases of stroke, but about two thirds of patients never fully restore language ability. The purpose of this study was to explore the intervention effect of high definition transcranial alternating current stimulation in chronic post-stroke aphasia. 40 patients with language disorder diagnosed by the Aphasia Battery of Chinese (ABC) were recruited from the first affiliated Hospital of Anhui Medical University. All participants underwent a structured interview and routine laboratory examination before and after receiving HD-tACS. After meeting the inclusion criteria and obtaining informed consent, each participant will complete the clinical evaluation, functional magnetic resonance imaging (fMRI) and HD-tACS treatment conducted by trained researchers at the Neuropsychological Synergetic Innovation Center of Anhui Medical University. @@ -833,7 +814,7 @@ severe dysarthria. a history of head injury or surgery. alcohol or substance abuse. cerebral tumor or abscess.","No","18 Years","All","Hefei",NA,NA,"WANG KAI","China",1,"no",117.349720247305,31.0729498560408,2021-03-18 -"36",36,"Improving Aphasia Using Electrical Brain Stimulation","Stroke Aphasia","July 12, 2021","NCT04963803","Syracuse University Syracuse New York United States","Syracuse University","Recruiting","Language and communication are essential for almost every aspect of human life, but for people who have aphasia, a language processing disorder that can occur after stroke or brain injury, even simple conversations can become a formidable challenge. Speech and language therapy can help people recover their language ability, but often requires months or even years of therapy before a person is able to overcome these challenges. This research will investigate non-invasive brain stimulation as a way to enhance the effects of speech and language therapy, which may ultimately lead to better and faster recovery from stroke and aphasia. The investigators hypothesize that participants with aphasia who receive speech and language therapy paired with active electrical brain stimulation will improve significantly more on a language comprehension task than those who receive speech and language therapy paired with sham stimulation.",NA,"tDCS attention language speech-language therapy","Interventional","Inclusion Criteria: +"35",35,"Improving Aphasia Using Electrical Brain Stimulation","Stroke Aphasia","July 12, 2021","NCT04963803","Syracuse University Syracuse New York United States","Syracuse University","Recruiting","Language and communication are essential for almost every aspect of human life, but for people who have aphasia, a language processing disorder that can occur after stroke or brain injury, even simple conversations can become a formidable challenge. Speech and language therapy can help people recover their language ability, but often requires months or even years of therapy before a person is able to overcome these challenges. This research will investigate non-invasive brain stimulation as a way to enhance the effects of speech and language therapy, which may ultimately lead to better and faster recovery from stroke and aphasia. The investigators hypothesize that participants with aphasia who receive speech and language therapy paired with active electrical brain stimulation will improve significantly more on a language comprehension task than those who receive speech and language therapy paired with sham stimulation.",NA,"tDCS attention language speech-language therapy","Interventional","Inclusion Criteria: 18 years or older. No diagnosis of neurological disorder (other than stroke). @@ -868,7 +849,7 @@ No aphasia or severe aphasia. Cognitive ability below functional limits. Unable to pass vision and/or hearing screening with use of corrective aids. Unwilling to allow audio-recording of study sessions.","No","18 Years","All","Syracuse","13244","New York",NA,"United States",1,"no",-76.1713255,43.0215885,2021-07-12 -"37",38,"Speeded Anomia Treatment in Chronic Post-stroke Aphasia","Aphasia","January 15, 2023","NCT05512884","University of Cambridge Cambridge NA United Kingdom","University of Cambridge","Recruiting","The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord).","The main aim is to test the clinical efficacy of a novel, web based, rehabilitation approach to aphasic word-finding difficulties (QuickWord). In an initial development and case-series evaluation, Conroy et al (2018, Brain) found that training for both speed as well as accuracy of naming generated much better outcomes to picture naming accuracy and also augmented the carry-over to connected speech production. +"36",37,"Speeded Anomia Treatment in Chronic Post-stroke Aphasia","Aphasia","January 15, 2023","NCT05512884","University of Cambridge Cambridge NA United Kingdom","University of Cambridge","Recruiting","The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord).","The main aim is to test the clinical efficacy of a novel, web based, rehabilitation approach to aphasic word-finding difficulties (QuickWord). In an initial development and case-series evaluation, Conroy et al (2018, Brain) found that training for both speed as well as accuracy of naming generated much better outcomes to picture naming accuracy and also augmented the carry-over to connected speech production. This is a randomised, crossover, clinical trial of QuickWord in a group of aphasic patients in the chronic post-stroke period. The comparison will be standard care. The main outcome measures are clinically relevant improvement in naming to confrontation, and spontaneous use of the target vocabulary in a connected speech sample (detailed picture description). Secondary outcome includes measured use of the vocabulary in a story-telling, connected speech assessment (retelling of the Cinderella story).","Anomia Speech Disorders Language Disorders Communication Disorders","Interventional","Inclusion Criteria: @@ -893,7 +874,7 @@ Unable to give informed consent Currently receiving Speech & Language therapy Insufficient repetition skills (<40% on an immediate word repetition test) Good naming performance (>90% in Boston Naming Test - Goodglass et al., 1983)","No","18 Years","All","Cambridge","CB2 7EF",NA,"Matthew A. Lambon Ralph","United Kingdom",1,"no",0.1216705,52.202776,2023-01-15 -"38",39,"Timing of Transcranial Direct Current Stimulation (tDCS) Combined With Speech and Language Therapy (SLT)","Aphasia","April 3, 2019","NCT03773406","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","Aphasia is an acquired (typically left-hemisphere) multi-modality disturbance of language that impacts around 2 million people in the USA. Aphasia impacts language production and comprehension as well as reading and writing. The ramifications of aphasia extend beyond language impairment to negatively impacting a person's social, vocational, and recreational activities. Currently, the most effective way to treat aphasia is with speech-language therapy (SLT). However, even if SLT is intensive, persons with aphasia are left with residual language delays. Recent research suggests that pairing SLT with transcranial direct current stimulation (tDCS) a non-invasive, safe, low-cost form of brain stimulation may aid language recovery in persons with aphasia. However, results from tDCS studies are inconclusive. The success of tDCS in combination with SLT could depend on the timing of tDCS since tDCS-induced effects depend on the neuronal state of the brain-networks at the time of the stimulation. In this study, the differential impact of tDCS before behavioral SLT (offline-before therapy), tDCS after SLT (offline-after therapy), and tDCS concurrently with SLT (online) on functional language recovery in persons with aphasia will be investigated. Sham tDCS (i.e., SLT alone) as a control group will also be included in the study. The investigators hypothesize that both offline and online tDCS will improve language functioning than sham tDCS.","tDCS Implementation: +"37",38,"Timing of Transcranial Direct Current Stimulation (tDCS) Combined With Speech and Language Therapy (SLT)","Aphasia","April 3, 2019","NCT03773406","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","Aphasia is an acquired (typically left-hemisphere) multi-modality disturbance of language that impacts around 2 million people in the USA. Aphasia impacts language production and comprehension as well as reading and writing. The ramifications of aphasia extend beyond language impairment to negatively impacting a person's social, vocational, and recreational activities. Currently, the most effective way to treat aphasia is with speech-language therapy (SLT). However, even if SLT is intensive, persons with aphasia are left with residual language delays. Recent research suggests that pairing SLT with transcranial direct current stimulation (tDCS) a non-invasive, safe, low-cost form of brain stimulation may aid language recovery in persons with aphasia. However, results from tDCS studies are inconclusive. The success of tDCS in combination with SLT could depend on the timing of tDCS since tDCS-induced effects depend on the neuronal state of the brain-networks at the time of the stimulation. In this study, the differential impact of tDCS before behavioral SLT (offline-before therapy), tDCS after SLT (offline-after therapy), and tDCS concurrently with SLT (online) on functional language recovery in persons with aphasia will be investigated. Sham tDCS (i.e., SLT alone) as a control group will also be included in the study. The investigators hypothesize that both offline and online tDCS will improve language functioning than sham tDCS.","tDCS Implementation: 2mA of direct current for 20 minutes will be delivered using a constant current stimulator via two electrodes in saline soaked sponges. To stimulate the left angular gyrus, a cathodal electrode inside a saline soaked sponge (5 x 3cm) will be placed over the CP5 according to the 10-20 international system for EEG electrode placement. The electrodes will be secured in position by a custom-built EEG cap that will be marked with the location for angular gyrus. The investigators will then confirm that the cathodal electrode is over the left angular through the use of neuronavigation. The ""return"" anode electrode will be placed in a saline soaked sponge (5 x 5cm) on the center of the supraorbital region. @@ -922,7 +903,7 @@ Exclusion Criteria: Any other neurological condition (other than cerebral vascular disease) that could impact language and cognition such as Alzheimer's disease, Parkinson's disease, primary progressive aphasia, and traumatic brain injury Active substance use Individuals with epilepsy","No","18 Years","All","Chicago","60611","Illinois","Leora Cherney","United States",1,"no",-87.618428,41.893889,2019-04-03 -"39",44,"Speech Entrainment Treatment for People With Aphasia","Aphasia, Acquired","January 25, 2023","NCT05687994","Albert Einstein Healthcare Network Elkins Park Pennsylvania United States","Albert Einstein Healthcare Network","Recruiting","The objective of this research is to experimentally delineate the direct effect of speech entrainment practice on independent speech production and identify practice conditions that enhance treatment benefits. The primary outcome measure (Correct Information Units per minute) tallies informativeness and efficiency of independent speech in treated stories.","Speech entrainment refers to speaking in unison with a model speaker by imitating the model in real time. The objective of the study is to (1) experimentally establish the direct effect of speech entrainment practice on independent speech production post-treatment, and (2) identify conditions that enhance treatment benefits. These aims are addressed in a within-subject efficacy study, where 40 people with aphasia produce different stories with entrainment support. Speaking without entrainment is evaluated one day before and one day after speech entrainment practice. Different practice stories will be randomized within participants to three experimental conditions to assess the effect of treatment (trained vs. untrained), training schedule (massed vs. distributed presentation of stories), and entrainment modality (practice with auditory-only or audiovisual model). Correct information units per minute for each story will be tallied to evaluate the differences between conditions and the associations with patient characteristics. For consistency with prior research, number of different words per minute will serve as a secondary outcome. The proposed research addresses a clinical need by testing and optimizing a promising treatment technique for enhancing aphasia rehabilitation. +"38",43,"Speech Entrainment Treatment for People With Aphasia","Aphasia, Acquired","January 25, 2023","NCT05687994","Albert Einstein Healthcare Network Elkins Park Pennsylvania United States","Albert Einstein Healthcare Network","Recruiting","The objective of this research is to experimentally delineate the direct effect of speech entrainment practice on independent speech production and identify practice conditions that enhance treatment benefits. The primary outcome measure (Correct Information Units per minute) tallies informativeness and efficiency of independent speech in treated stories.","Speech entrainment refers to speaking in unison with a model speaker by imitating the model in real time. The objective of the study is to (1) experimentally establish the direct effect of speech entrainment practice on independent speech production post-treatment, and (2) identify conditions that enhance treatment benefits. These aims are addressed in a within-subject efficacy study, where 40 people with aphasia produce different stories with entrainment support. Speaking without entrainment is evaluated one day before and one day after speech entrainment practice. Different practice stories will be randomized within participants to three experimental conditions to assess the effect of treatment (trained vs. untrained), training schedule (massed vs. distributed presentation of stories), and entrainment modality (practice with auditory-only or audiovisual model). Correct information units per minute for each story will be tallied to evaluate the differences between conditions and the associations with patient characteristics. For consistency with prior research, number of different words per minute will serve as a secondary outcome. The proposed research addresses a clinical need by testing and optimizing a promising treatment technique for enhancing aphasia rehabilitation. This proof-of-concept study is the first to evaluate the direct effect of speech entrainment practice on independent speech. Thus, the effect size for accurate power estimation is not known. The strategy for this study is to optimize experimental sensitivity by maximizing the number of observations per participants per condition within the constraints of feasibility. The results from this study will provide critical information for evaluating the effect size for a subsequent phase. Nevertheless, to estimate an optimal sample size, the investigators leveraged the data from our Pilot Study, which examines the speech entrainment effect on immediate performance rather than learning. With 13 participants, the investigators estimated 80% power to detect the effect of 0.8 (mean difference between groups divided by the pooled standard deviation) observed in our pilot study for speaking with audiovisual speech entrainment vs. independent speech (Aim 1). The calculation is based on a paired t-test with an alpha of .05 (two-tailed) and a correlation of 0.5 between groups. With 24 participants, there is 80% power to detect the observed effect of 0.6 for speaking with audiovisual speech entrainment vs. auditory-only speech entrainment (alpha is set to .05, two-tailed, correlation between groups is .57; Aim 2b). The investigators have substantially increased the sample size (N=40) with the consideration that learning effects (the focus of the present study) are expected to be smaller than performance effects (the focus of the Pilot Study).","","Interventional","Inclusion Criteria: @@ -937,7 +918,7 @@ Exclusion Criteria: History of learning disabilities History of other comorbid neurological impairments","No","18 Years","All","Elkins Park","19027","Pennsylvania","Marja-Liisa Mailend, PhD","United States",1,"no",-75.120418,40.035597,2023-01-25 -"40",47,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Bron Cedex NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. +"39",46,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Bron Cedex NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. The aim of this study is to show that a motor training with a tool (pliers) can improve short-term and long-term language abilities of aphasic patients who had a stroke at least 3 months ago. @@ -976,7 +957,7 @@ Recurrence of a stroke impacting the reorganisation of neural networks Persons deprived of their liberty by a judicial or administrative decision Persons of legal age under a legal protection measure (guardianship, curatorship) Pregnant women, women in labour or nursing mothers, confirmed by questioning the participant Participation in another study at the same time as this one","Accepts Healthy Volunteers","18 Years","All","Bron Cedex","69500",NA,NA,"France",1,"no",4.83742,45.759372,2023-05-26 -"41",47,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Bron NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. +"40",46,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Bron NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. The aim of this study is to show that a motor training with a tool (pliers) can improve short-term and long-term language abilities of aphasic patients who had a stroke at least 3 months ago. @@ -1015,7 +996,7 @@ Recurrence of a stroke impacting the reorganisation of neural networks Persons deprived of their liberty by a judicial or administrative decision Persons of legal age under a legal protection measure (guardianship, curatorship) Pregnant women, women in labour or nursing mothers, confirmed by questioning the participant Participation in another study at the same time as this one","Accepts Healthy Volunteers","18 Years","All","Bron","69500",NA,NA,"France",1,"no",4.83742,45.759372,2023-05-26 -"42",47,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Saint-Genis-Laval NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. +"41",46,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Saint-Genis-Laval NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. The aim of this study is to show that a motor training with a tool (pliers) can improve short-term and long-term language abilities of aphasic patients who had a stroke at least 3 months ago. @@ -1054,7 +1035,7 @@ Recurrence of a stroke impacting the reorganisation of neural networks Persons deprived of their liberty by a judicial or administrative decision Persons of legal age under a legal protection measure (guardianship, curatorship) Pregnant women, women in labour or nursing mothers, confirmed by questioning the participant Participation in another study at the same time as this one","Accepts Healthy Volunteers","18 Years","All","Saint-Genis-Laval","69230",NA,NA,"France",1,"no",4.792883,45.695002,2023-05-26 -"43",48,"Combining tDCS and CILT in Non-fluent Aphasia","Aphasia Non-fluent Aphasia Stroke Brain Injuries","April 24, 2023","NCT05561400","University of Minnesota Duluth Minnesota United States","University of Minnesota","Recruiting","The long-term goal of this work is to determine if combining a highly intensive, task-specific behavioral language intervention with modulation of the efferent cerebellar-cortical pathway using transcranial direct current stimulation (tDCS) has a positive influence on discourse, verbal fluency and working memory in individuals with non-fluent aphasia after stroke. And if these changes can be related to neuroplastic change in the cerebellar cortical pathway indirectly measured through neurophysiologic changes using spectral electroencephalogram (EEG). The initial phase includes the proposed pilot study data from which will be used to inform a larger clinical trial. The primary aims of this pilot are to 1) determine the effect of combining cerebellar tDCS with constraint-induced language therapy (CILT) on language as measured by a verbal fluency task and discourse task in a small population and 2) identify the tolerance of the intervention and barriers to participation measured by the adverse events questionnaire that will inform the methodology of a larger study. The secondary aims include estimating the size of the treatment effect on 1) delta percentage in F3, F7 and Fp1 compared to F4, F8, and Fp2 using resting state EEG spectral analysis and coherence, 2) working memory as measured by the score on the n-back test and 3) quality of life as measured by the Stroke Aphasia Quality of Life survey tool. The secondary aims will be used to determine the utility of these measures in a larger clinical trial. +"42",47,"Combining tDCS and CILT in Non-fluent Aphasia","Aphasia Non-fluent Aphasia Stroke Brain Injuries","April 24, 2023","NCT05561400","University of Minnesota Duluth Minnesota United States","University of Minnesota","Recruiting","The long-term goal of this work is to determine if combining a highly intensive, task-specific behavioral language intervention with modulation of the efferent cerebellar-cortical pathway using transcranial direct current stimulation (tDCS) has a positive influence on discourse, verbal fluency and working memory in individuals with non-fluent aphasia after stroke. And if these changes can be related to neuroplastic change in the cerebellar cortical pathway indirectly measured through neurophysiologic changes using spectral electroencephalogram (EEG). The initial phase includes the proposed pilot study data from which will be used to inform a larger clinical trial. The primary aims of this pilot are to 1) determine the effect of combining cerebellar tDCS with constraint-induced language therapy (CILT) on language as measured by a verbal fluency task and discourse task in a small population and 2) identify the tolerance of the intervention and barriers to participation measured by the adverse events questionnaire that will inform the methodology of a larger study. The secondary aims include estimating the size of the treatment effect on 1) delta percentage in F3, F7 and Fp1 compared to F4, F8, and Fp2 using resting state EEG spectral analysis and coherence, 2) working memory as measured by the score on the n-back test and 3) quality of life as measured by the Stroke Aphasia Quality of Life survey tool. The secondary aims will be used to determine the utility of these measures in a larger clinical trial. This is a prospective, crossover study, sham-controlled intervention study with two intervention conditions delivered across 6 intervention sessions (3x/week for two weeks) with a 4-week washout in between. Conditions include: 1) sham cerebellar tDCS and 2) real cerebellar tDCS delivered at 2mA across 20 minutes. Each of these will be delivered during CILT intervention with a licensed, certified speech-language pathologist trained in CILT. Once tDCS stimulation has ended, CILT will continue to be delivered for an additional 25 minutes. Assessments of discourse, verbal fluency, working memory and EEG spectral analysis will be conducted at four timepoints, before and after each intervention phase.","This is a prospective sham-controlled, cross-over design. Eligible participants must be over the age of 18 years, be > least 6 months post unilateral cortical stroke and diagnosed with mild to moderate non-fluent aphasia. Additional inclusion/exclusionary criteria have been specified in and approved by the IRB. Six to seven participants are expected to be recruited and screened, with the goal to enroll and complete the study with four individuals who will be randomly assigned to receive either sham or real condition first. The two intervention conditions include: 1) andodal tDCS (2mA) to the right posterior-lateral cerebellum and 2) sham tDCS to the right posterior-lateral cerebellum. The participants will receive 20 minutes of tDCS (sham or real) during CILT followed by an additional 25 minutes of CILT alone. Each condition will be administered 3 days per week for two weeks for a total of 6 intervention sessions with a 4-week washout period between. @@ -1077,7 +1058,7 @@ history of migraines, psoriasis or eczema affecting the scalp, history of a head injury such as a concussion diagnosis of a mental health or neurological condition/disease.","No","18 Years","All","Duluth","55812","Minnesota",NA,"United States",1,"no",-92.08343,46.8190805,2023-04-24 -"44",49,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"43",48,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1100,7 +1081,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Baltimore","21287","Maryland",NA,"United States",1,"no",-76.6204945,39.3289375,2021-07-18 -"45",49,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Charleston South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"44",48,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Charleston South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1123,7 +1104,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Charleston","29425","South Carolina",NA,"United States",1,"no",-80.10815,32.792398,2021-07-18 -"46",49,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Columbia South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"45",48,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Columbia South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1146,7 +1127,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Columbia","29208","South Carolina",NA,"United States",1,"no",-81.034331,34.000749,2021-07-18 -"47",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Aachen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"46",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Aachen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1171,7 +1152,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Aachen","52074",NA,NA,"Germany",1,"no",6.083862,50.776351,2019-12-06 -"48",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Allensbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"47",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Allensbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1196,7 +1177,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Allensbach","78476",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"49",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Aibling NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"48",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Aibling NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1221,7 +1202,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Aibling","83209",NA,NA,"Germany",1,"no",12.009768,47.86405,2019-12-06 -"50",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Homburg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"49",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Homburg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1246,7 +1227,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Homburg","61348",NA,NA,"Germany",1,"no",8.618313,50.228032,2019-12-06 -"51",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Klosterlausnitz NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"50",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Klosterlausnitz NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1271,7 +1252,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Klosterlausnitz","07639",NA,NA,"Germany",1,"no",11.86817,50.916262,2019-12-06 -"52",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Sülze NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"51",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Sülze NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1296,7 +1277,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Sülze","18334",NA,NA,"Germany",1,"no",12.658113,54.111965,2019-12-06 -"53",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Berlin NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"52",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Berlin NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1321,7 +1302,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Berlin","10115",NA,NA,"Germany",1,"no",13.3888599,52.5170365,2019-12-06 -"54",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Gailingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"53",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Gailingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1346,7 +1327,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Gailingen","78262",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"55",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"54",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1371,7 +1352,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Greifswald","17475",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"56",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"55",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1396,7 +1377,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Greifswald","17491",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"57",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Göppingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"56",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Göppingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1421,7 +1402,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Göppingen","73035",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"58",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Heidelberg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"57",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Heidelberg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1446,7 +1427,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Heidelberg","69117",NA,NA,"Germany",1,"no",8.7112746,49.4121677,2019-12-06 -"59",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Kempen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"58",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Kempen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1471,7 +1452,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Kempen","47906",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"60",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Leipzig NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"59",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Leipzig NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1496,7 +1477,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Leipzig","04103",NA,NA,"Germany",1,"no",12.374733,51.340632,2019-12-06 -"61",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Lindlar NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"60",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Lindlar NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1521,7 +1502,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Lindlar","51789",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"62",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Marbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"61",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Marbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1546,7 +1527,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Marbach","71672",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"63",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Meerbusch NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"62",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Meerbusch NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1571,7 +1552,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Meerbusch","40670",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"64",51,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Vechta NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"63",50,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Vechta NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1596,7 +1577,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Vechta","49377",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"65",56,"Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia","Aphasia Apraxia of Speech","December 4, 2018","NCT05248295","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech are most helpful. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? A possible mechanism for this benefit is examined, by testing whether the degree of alignment of a person's speech with that of another speaker can account for unison benefit.","Aphasia is an acquired language disorder, most commonly due to stroke. It can affect an individual's ability to speak, understand spoken language, read, and write. Many treatments designed to improve spoken language in persons with aphasia (PWAs) use unison speech, having the person with aphasia speak along with the clinician or with a recording. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech help them the most. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? This knowledge is important because understanding who benefits from this commonly used and potentially powerful therapy component, under which conditions they benefit, and why they do, is critical for customizing therapy so it can be as effective and efficient as possible. Unison speech is conducted using one of two different timing patterns: (1) a natural conversational pattern, which is used in everyday conversations, or (2) a metrical pattern, which follows a beat-based timing framework, as in songs or some poems. In either case, precisely aligning one's speech with that of another person (i.e., entraining one's speech) requires prediction: each speaker must plan their own speech motor commands before having heard the other speaker say the words they are planning. Natural conversational timing requires the speaker to make use of knowledge about language, particularly grammar, to align with the other person. In contrast, a metrical pattern allows a speaker to predict speech timing without relying heavily on language-based knowledge. Given that many PWAs have impaired grammar, we hypothesize that most PWAs will benefit more from speaking in unison to sentences with metrical vs. conversational timing patterns. However, there is great variation in linguistic, motor speech, and timing skills across PWAs, so metrical and conversational timing patterns are likely to have different degrees of effectiveness for different individuals. Results from this study will demonstrate how individual characteristics and speech timing affect whether or not a person with aphasia benefits from speaking in unison. Results will also indicate whether a speaker's ability to predict speech timing is necessary for a benefit of unison speech. Prediction ability will be measured by how closely the speaker aligns their speech with a spoken model.","","Interventional","Inclusion Criteria: +"64",55,"Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia","Aphasia Apraxia of Speech","December 4, 2018","NCT05248295","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech are most helpful. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? A possible mechanism for this benefit is examined, by testing whether the degree of alignment of a person's speech with that of another speaker can account for unison benefit.","Aphasia is an acquired language disorder, most commonly due to stroke. It can affect an individual's ability to speak, understand spoken language, read, and write. Many treatments designed to improve spoken language in persons with aphasia (PWAs) use unison speech, having the person with aphasia speak along with the clinician or with a recording. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech help them the most. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? This knowledge is important because understanding who benefits from this commonly used and potentially powerful therapy component, under which conditions they benefit, and why they do, is critical for customizing therapy so it can be as effective and efficient as possible. Unison speech is conducted using one of two different timing patterns: (1) a natural conversational pattern, which is used in everyday conversations, or (2) a metrical pattern, which follows a beat-based timing framework, as in songs or some poems. In either case, precisely aligning one's speech with that of another person (i.e., entraining one's speech) requires prediction: each speaker must plan their own speech motor commands before having heard the other speaker say the words they are planning. Natural conversational timing requires the speaker to make use of knowledge about language, particularly grammar, to align with the other person. In contrast, a metrical pattern allows a speaker to predict speech timing without relying heavily on language-based knowledge. Given that many PWAs have impaired grammar, we hypothesize that most PWAs will benefit more from speaking in unison to sentences with metrical vs. conversational timing patterns. However, there is great variation in linguistic, motor speech, and timing skills across PWAs, so metrical and conversational timing patterns are likely to have different degrees of effectiveness for different individuals. Results from this study will demonstrate how individual characteristics and speech timing affect whether or not a person with aphasia benefits from speaking in unison. Results will also indicate whether a speaker's ability to predict speech timing is necessary for a benefit of unison speech. Prediction ability will be measured by how closely the speaker aligns their speech with a spoken model.","","Interventional","Inclusion Criteria: Native-speaker fluency in American English (prior to stroke for people with aphasia) Controls must report no history of speech, language, neurological disorders, or stroke @@ -1608,7 +1589,7 @@ Inadequate hearing ability to reliably complete task: fail hearing screen Inadequate cognitive ability to understand and remember task: fail cognition screening (different measures for controls and people with aphasia) Inadequate speech repetition ability to complete task, or to be considered a control: fail speech repetition screening (different thresholds for controls and people with aphasia) Inadequate auditory comprehension ability to understand task: fail auditory comprehension screen (people with aphasia only)","Accepts Healthy Volunteers","18 Years","All","Boston","02129","Massachusetts","Lauryn Zipse, Ph.D., CCC-SLP","United States",1,"no",-71.0537615,42.3756115,2018-12-04 -"66",58,"Individualized Precision rTMS for Language Recovery in Patients After Ischemic Stroke: a Multi-center RCT","Stroke, Ischemic Aphasia","June 5, 2023","NCT05842304","Changping Laboratory Beijing NA China","Changping Laboratory","Recruiting","The current multi-center study aims to evaluate the efficacy and safety of pBFS-guided rTMS Neuromodulation Treatment for the rehabilitation of language functions in ischemic stroke aphasic patients.","Increasing evidence suggests that rTMS has been effective in treating various psychological and neurological diseases, including treating post-stroke symptoms. Using the personalized brain functional sectors (pBFS) technique, we could precisely identify individualized brain functional networks and the personalized language-related stimulation site based on the resting-state functional MRI data. The current study proposes to conduct a multi-center, double-blinded, randomized and parallel controlled design trial, to investigate the efficacy and safety of pBFS-guided personalized TMS intervention in post-stroke aphasic patients. +"65",57,"Individualized Precision rTMS for Language Recovery in Patients After Ischemic Stroke: a Multi-center RCT","Stroke, Ischemic Aphasia","June 5, 2023","NCT05842304","Changping Laboratory Beijing NA China","Changping Laboratory","Recruiting","The current multi-center study aims to evaluate the efficacy and safety of pBFS-guided rTMS Neuromodulation Treatment for the rehabilitation of language functions in ischemic stroke aphasic patients.","Increasing evidence suggests that rTMS has been effective in treating various psychological and neurological diseases, including treating post-stroke symptoms. Using the personalized brain functional sectors (pBFS) technique, we could precisely identify individualized brain functional networks and the personalized language-related stimulation site based on the resting-state functional MRI data. The current study proposes to conduct a multi-center, double-blinded, randomized and parallel controlled design trial, to investigate the efficacy and safety of pBFS-guided personalized TMS intervention in post-stroke aphasic patients. Subjects will be randomly assigned to the following two groups: active continuous TBS (cTBS) group, or a sham control group. The allocation ratio will be 2:1. Subjects will receive a 3-week treatment for 21 consecutive days. The stimulation procedure will be assisted with real-time neuronavigation to ensure its precision.","","Interventional","Inclusion Criteria: @@ -1637,7 +1618,7 @@ History of alcohol, drug, and/or other abuse. Patients with other test abnormalities judged by the investigator to be unsuitable for the trial. Women of childbearing age who are pregnant or preparing for pregnancy. Patients who are participating in other clinical research trials.","No","35 Years","All","Beijing",NA,NA,NA,"China",1,"no",116.225091,40.219646,2023-06-05 -"67",61,"Treatment Outcomes With tDCS in Post-Stroke Aphasia","Aphasia","September 3, 2019","NCT03929432","University of Arkansas Little Rock Arkansas United States","University of Arkansas","Recruiting","The purpose this study is to test the utility of pairing external neuromodulation with behavioral language treatment to boost therapy outcomes and to investigate the mechanisms associated with recovery. Because all PWA have word retrieval deficits, this project will test if greater language gains can be achieved by supplementing anomia intervention with excitatory brain stimulation to the left hemisphere and will evaluate associated functional brain changes to aid the optimization of neural reorganization to facilitate language processing.","Aphasia is a language impairment that commonly occurs following brain damage (e.g., stroke). While language rehabilitation can yield improved language functioning, treatment outcomes vary greatly across individuals. In chronic aphasia, language gains occur through the brain's inherent ability to reorganize (i.e., neuroplasticity). +"66",60,"Treatment Outcomes With tDCS in Post-Stroke Aphasia","Aphasia","September 3, 2019","NCT03929432","University of Arkansas Little Rock Arkansas United States","University of Arkansas","Recruiting","The purpose this study is to test the utility of pairing external neuromodulation with behavioral language treatment to boost therapy outcomes and to investigate the mechanisms associated with recovery. Because all PWA have word retrieval deficits, this project will test if greater language gains can be achieved by supplementing anomia intervention with excitatory brain stimulation to the left hemisphere and will evaluate associated functional brain changes to aid the optimization of neural reorganization to facilitate language processing.","Aphasia is a language impairment that commonly occurs following brain damage (e.g., stroke). While language rehabilitation can yield improved language functioning, treatment outcomes vary greatly across individuals. In chronic aphasia, language gains occur through the brain's inherent ability to reorganize (i.e., neuroplasticity). While Speech-language therapy (SLT) can target various language skills and modalities, the most pervasive deficit across all persons with aphasia (PWA) is difficulty with word finding. Thus, aphasia treatment often includes some form of intervention focused on improving naming abilities. As with language function in general, naming abilities in PWA seems to be associated with left hemisphere recruitment, particularly with the viable tissue at the rim of the lesion (perilesional areas). This project investigates an innovative approach to improving current therapy by examining the benefits of using excitatory transcranial direct current stimulation (tDCS) stimulation/neuromodulation during anomia treatment (i.e. word-finding treatment). @@ -1664,7 +1645,7 @@ Co-occurring history of neurological disease/disorder/injury (e.g., traumatic br Co-occurring history of a major mental illness (e.g., schizophrenia, drug addiction, bipolar) Clinical conditions contraindicated for MRI or tDCS (e.g., implanted electrical devices, claustrophobia, seizure disorder) Positive pregnancy test (for females)","No","18 Years","All","Little Rock","72205","Arkansas",NA,"United States",1,"no",-92.3396525,34.7224165,2019-09-03 -"68",72,"Transcranial Alternating Current Stimulation (tACS) in Aphasia","Aphasia Stroke","January 4, 2020","NCT04375722","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States (NIH-NIDCD, 2015). Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits by providing brain stimulation concurrent with therapies. Transcranial direct current stimulation (tDCS) is one of the most widely used such technique. While tDCS has had relative success in chronic aphasia (>6 months after stroke), it has not been efficacious during subacute stages (<3 months after stroke). But enhancing language recovery early after stroke is desirable because of its potential impact on long-term language outcomes and quality-of-life. +"67",72,"Transcranial Alternating Current Stimulation (tACS) in Aphasia","Aphasia Stroke","January 4, 2020","NCT04375722","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States (NIH-NIDCD, 2015). Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits by providing brain stimulation concurrent with therapies. Transcranial direct current stimulation (tDCS) is one of the most widely used such technique. While tDCS has had relative success in chronic aphasia (>6 months after stroke), it has not been efficacious during subacute stages (<3 months after stroke). But enhancing language recovery early after stroke is desirable because of its potential impact on long-term language outcomes and quality-of-life. The current study will investigate the efficacy of high-definition tACS (HD-tACS) to help restore neural oscillatory activity in aphasia. TACS differs from tDCS in that sinusoidal, alternating currents are delivered rather than constant currents. TACS can manipulate the ongoing oscillatory neuronal activity and potentially increase functional synchronization (or connectivity) between targeted areas. This feature of tACS is quite attractive, given the new body of evidence suggesting that language impairments stem from diminished functional connectivity and disruptions in the language network due to stroke. The selection of tACS frequencies in this study is guided by our preliminary work examining pathological neural oscillations found near stroke-lesioned areas (or perilesional) in aphasia. By exogenously tuning the perilesional oscillations with tACS, the investigators hope to up-regulate communication across these areas and other connected areas to improve language outcome. If successful, tACS will be a powerful and novel treatment approach with reverberating positive impact on long-term recovery. @@ -1696,7 +1677,7 @@ Any metal implants in the skull Contraindications to MRI or tACS History of seizures History of dyslexia or other developmental learning disabilities","Accepts Healthy Volunteers","18 Years","All","Milwaukee","53226","Wisconsin","Priyanka Shah-Basak, PhD","United States",1,"no",-88.022002,43.04338,2020-01-04 -"69",77,"Treatment of Grammatical Time Marking in Post-Stroke Aphasia","Brain Injury, Vascular Aphasia Stroke","December 30, 2022","NCT05656638","University of Neuchatel Neuchâtel NA Switzerland","University of Neuchatel","Recruiting","The study aims to assess a individual or group therapy's effectiveness in grammatical time marking. The main objective is to examine whether the therapy improves grammatical time marking of inflected verbs treated on the sessions. We also explore whether the observed progress can be transferred to untrained items, more ecological contexts and if is maintained two and four weeks after the end of treatment. +"68",77,"Treatment of Grammatical Time Marking in Post-Stroke Aphasia","Brain Injury, Vascular Aphasia Stroke","December 30, 2022","NCT05656638","University of Neuchatel Neuchâtel NA Switzerland","University of Neuchatel","Recruiting","The study aims to assess a individual or group therapy's effectiveness in grammatical time marking. The main objective is to examine whether the therapy improves grammatical time marking of inflected verbs treated on the sessions. We also explore whether the observed progress can be transferred to untrained items, more ecological contexts and if is maintained two and four weeks after the end of treatment. This therapy will be administered to nine individuals with brain lesions after stroke. Five individuals will take part of the individual therapy and four individuals will take part of the group therapy (two individuals per group). The therapy will last one month, at the rate of three weekly sessions of approximately one hour.",NA,"","Interventional","Inclusion Criteria: @@ -1713,7 +1694,7 @@ Have significant impairments in oral/written comprehension. Present apraxia of speech or a severe arthritic disorder Present hemineglect Present impaired judgment and discernment, objectified by a neuropsychological evaluation","No","18 Years","All","Neuchâtel","2000",NA,"Marion Fossard","Switzerland",1,"no",6.931074,46.993392,2022-12-30 -"70",80,"Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia","Stroke Aphasia Apraxia of Speech","July 22, 2020","NCT04816799","Arizona State University Tempe Arizona United States","Arizona State University","Recruiting","A stratified, parallel-group, double-blind, randomized controlled trial of remotely delivered START treatment to individuals with severe-to-moderate stroke (with recruitment focused on individuals with low SES) will be conducted. Subjects and assessors will be blinded to the condition making the experiment double blind. Specifically, subjects will be told that we are exploring a new therapy that using different sounds to improve therapy. Parallel group design will ensure that subjects in the Control group are unaware that their ""sounds"" are softer than the START group. Trainers may become aware that a loud sound is present thus a unique Assessor will evaluate clinical performance before and after training making the study double-blind. Fifty-four subjects will undergo baseline testing in the laboratory to establish their capacity for functional and expressive speech as well as their self-reported health-related quality of life (power analysis below). Next, subjects will participate in a high-frequency, word-picture verification/ auditory-repetition treatment, 2 hr/day for 5 consecutive days focusing on expression of words of functional significance (e.g., water, fall). Subjects will either receive training with START or without (Control). Subjects will be re-tested immediately following training as well as one-month post to assess retention. Aim 1 will evaluate capacity of START to enhance SLT outcomes by assessing the % change in clinical assessment of functional and expressive speech. Our preliminary data points to a robust response [details]. Aim 2 will focus on the capacity of these changes to 1) be retained and 2) impact subject's reported quality of life. NOTE: While we are planning in-person baseline, end, and retention testing, in response to COVID, we have established remote clinical screening using peer-reviewed validated techniques for WAB and ABA-2 (see Alternative Solutions). All preliminary data collected for this proposal were collected remotely via no-contact protocols.",NA,"","Interventional","Inclusion Criteria: +"69",80,"Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia","Stroke Aphasia Apraxia of Speech","July 22, 2020","NCT04816799","Arizona State University Tempe Arizona United States","Arizona State University","Recruiting","A stratified, parallel-group, double-blind, randomized controlled trial of remotely delivered START treatment to individuals with severe-to-moderate stroke (with recruitment focused on individuals with low SES) will be conducted. Subjects and assessors will be blinded to the condition making the experiment double blind. Specifically, subjects will be told that we are exploring a new therapy that using different sounds to improve therapy. Parallel group design will ensure that subjects in the Control group are unaware that their ""sounds"" are softer than the START group. Trainers may become aware that a loud sound is present thus a unique Assessor will evaluate clinical performance before and after training making the study double-blind. Fifty-four subjects will undergo baseline testing in the laboratory to establish their capacity for functional and expressive speech as well as their self-reported health-related quality of life (power analysis below). Next, subjects will participate in a high-frequency, word-picture verification/ auditory-repetition treatment, 2 hr/day for 5 consecutive days focusing on expression of words of functional significance (e.g., water, fall). Subjects will either receive training with START or without (Control). Subjects will be re-tested immediately following training as well as one-month post to assess retention. Aim 1 will evaluate capacity of START to enhance SLT outcomes by assessing the % change in clinical assessment of functional and expressive speech. Our preliminary data points to a robust response [details]. Aim 2 will focus on the capacity of these changes to 1) be retained and 2) impact subject's reported quality of life. NOTE: While we are planning in-person baseline, end, and retention testing, in response to COVID, we have established remote clinical screening using peer-reviewed validated techniques for WAB and ABA-2 (see Alternative Solutions). All preliminary data collected for this proposal were collected remotely via no-contact protocols.",NA,"","Interventional","Inclusion Criteria: 18 years old Native English Speakers @@ -1727,7 +1708,7 @@ Corrected pure tone threshold (octave frequencies 250- 4000 Hz) norms for their Exclusion Criteria: Severe concurrent uncontrolled medical problems (e.g. cardiorespiratory impairment).","No","18 Years","All","Tempe","85287","Arizona","Claire Honeycutt","United States",1,"no",-111.932727,33.416893,2020-07-22 -"71",83,"tDCS Effects on Brain Plasticity in Aphasia Treatment","Aphasia Stroke","November 1, 2021","NCT05483556","The Hong Kong Polytechnic University Kowloon NA Hong Kong","The Hong Kong Polytechnic University","Recruiting","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI. +"70",83,"tDCS Effects on Brain Plasticity in Aphasia Treatment","Aphasia Stroke","November 1, 2021","NCT05483556","The Hong Kong Polytechnic University Kowloon NA Hong Kong","The Hong Kong Polytechnic University","Recruiting","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI. This randomized, placebo-controlled, double-blinded pilot study will recruit ten chronic stroke patients with Broca's Aphasia randomly assigned either to sham or an anodal tDCS groups. Following speech and language assessment, all the participants will receive 20 minutes of individualized language therapy daily for ten days in two consecutive weeks. Simultaneously, the treatment group will receive 20 minutes of 2mA anodal HD-tDCS over the left IFG, while the sham group will receive the 30s of 2mA anodal HD-tDCS. Structural, resting state and task activated functional MRI will be performed. Data acquisition will be performed before, immediately after and two months after the treatment. @@ -1748,7 +1729,7 @@ Wernicke's aphasia and other speech disorders, degenerative, psychiatric or meta Deaf, blind, pregnant/ or preparing for pregnancy, cognitive issues, tattoos Have cochlear implants, pacemaker, surgical nails for bone fracture, artificial joints, dental braces, dentures Taking anti-depressant medications","No","18 Years","All","Kowloon",NA,NA,"Dr Min Wong","Hong Kong",1,"no",114.179821,22.3046025,2021-11-01 -"72",85,"Effects of Verb Network Strengthening Treatment (VNeST) on Word Finding in Aphasia","Anomia Aphasia Stroke","January 16, 2022","NCT05152979","Göteborg University Gothenburg Västra Götaland Sweden","Göteborg University","Recruiting","Although there is evidence that speech-language therapy may improve speech in language disorders following left hemisphere stroke there is still a lack of evidence for which types of therapy are effective. Furthermore, in Sweden, as well as in several other countries, access to speech-language therapy is limited. The purpose of this clinical trial is to compare outcome from Verb Network Strengthening Treatment (VNeST) provided as In-Clinic therapy (I-CT) or as synchronous telepractice therapy (TP-T).","Every year thousands of persons in Sweden suffer from brain damage resulting in anomia, that is, word finding difficulties affecting their ability to talk to other people. Anomia is one of the most common and persistent symptoms of aphasia following a left hemisphere stroke, but it is also common in in progressive neurological diseases such as Parkinson's disease or multiple sclerosis (MS). There is evidence that more intensive speech language therapy may improve speech even in a chronic (> six month post stroke) phase of aphasia. However, access to the necessary amount of speech language therapy is limited due to lack of financial resources as well as to limitations to service providers in more rural areas. +"71",85,"Effects of Verb Network Strengthening Treatment (VNeST) on Word Finding in Aphasia","Anomia Aphasia Stroke","January 16, 2022","NCT05152979","Göteborg University Gothenburg Västra Götaland Sweden","Göteborg University","Recruiting","Although there is evidence that speech-language therapy may improve speech in language disorders following left hemisphere stroke there is still a lack of evidence for which types of therapy are effective. Furthermore, in Sweden, as well as in several other countries, access to speech-language therapy is limited. The purpose of this clinical trial is to compare outcome from Verb Network Strengthening Treatment (VNeST) provided as In-Clinic therapy (I-CT) or as synchronous telepractice therapy (TP-T).","Every year thousands of persons in Sweden suffer from brain damage resulting in anomia, that is, word finding difficulties affecting their ability to talk to other people. Anomia is one of the most common and persistent symptoms of aphasia following a left hemisphere stroke, but it is also common in in progressive neurological diseases such as Parkinson's disease or multiple sclerosis (MS). There is evidence that more intensive speech language therapy may improve speech even in a chronic (> six month post stroke) phase of aphasia. However, access to the necessary amount of speech language therapy is limited due to lack of financial resources as well as to limitations to service providers in more rural areas. It has been suggested that telepractice may increase the access to speech-language therapy for more people but there is a lack of knowledge of whether there is a difference in outcome from interventions provided as In-Clinic therapy (I-CT) or as telepractice therapy (TP-T). @@ -1770,7 +1751,7 @@ Moderately or severely impaired comprehension Moderate-severe apraxia of speech or dysarthria which may interfere with assessment Participation in any other speech-language treatment during the study Active substance dependence","No","18 Years","All","Gothenburg","40530","Västra Götaland",NA,"Sweden",1,"no",11.961307,57.6970935,2022-01-16 -"73",86,"Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia","Aphasia Non Fluent Stroke","May 5, 2022","NCT04433351","University Hospital, Grenoble Grenoble NA France","University Hospital, Grenoble","Recruiting","SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that aims first, to test and develop a novel speech rehabilitation program designed for patients with non-fluent aphasia and, second, to better describe neural reorganization after successful recovery. To this end, the investigators will conduct a prospective monocentric cross-over study, including two cohorts of post-stroke aphasic patients and two control groups.","In this project, the investigators propose to evaluate the effectiveness of a new rehabilitation program, based on illustration of speech articulators, to improve speech in patients with non-fluent aphasia. The instigators' method is based on the reinforcement of the interaction between perceptual and motor representations, thanks to the innovative Ultraspeech device. The investigators will exploit a fundamental psycholinguistic principle, which postulates that speech is based both on the activation of the system controlling the motricity of effectors related to word articulation (action) and on the auditory or visual representation of words (perception). The sensory-motor interaction method that the investigators propose allows the patient to perceive phonemes and visualize on a computer screen the movements of the tongue and lips previously recorded by a healthy speaker, typically a speech therapist. Through repeated exercises, the patient is trained to produce sounds correctly, using the correct pronunciation and articulatory movements of the reference speaker as a model. The investigators will compare patients who will follow a classical speech and language therapy rehabilitation program followed by an 'enriched' rehabilitation program including rehabilitation based on sensory-motor interaction associated with speech and language therapy, and vice versa. In order to judge the favorable effect of the rehabilitation program including sensory-motor integration, the following measures will be considered: (a) language skills, (b) phonemic quality, (c) inner speech abilities and (d) cognitive function. Brain language networks will be evaluated with neuroimaging.","post-stroke aphasia non-fluent aphasia speech rehabilitation neuroimaging neural reorganization recovery","Interventional","Inclusion Criteria: +"72",86,"Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia","Aphasia Non Fluent Stroke","May 5, 2022","NCT04433351","University Hospital, Grenoble Grenoble NA France","University Hospital, Grenoble","Recruiting","SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that aims first, to test and develop a novel speech rehabilitation program designed for patients with non-fluent aphasia and, second, to better describe neural reorganization after successful recovery. To this end, the investigators will conduct a prospective monocentric cross-over study, including two cohorts of post-stroke aphasic patients and two control groups.","In this project, the investigators propose to evaluate the effectiveness of a new rehabilitation program, based on illustration of speech articulators, to improve speech in patients with non-fluent aphasia. The instigators' method is based on the reinforcement of the interaction between perceptual and motor representations, thanks to the innovative Ultraspeech device. The investigators will exploit a fundamental psycholinguistic principle, which postulates that speech is based both on the activation of the system controlling the motricity of effectors related to word articulation (action) and on the auditory or visual representation of words (perception). The sensory-motor interaction method that the investigators propose allows the patient to perceive phonemes and visualize on a computer screen the movements of the tongue and lips previously recorded by a healthy speaker, typically a speech therapist. Through repeated exercises, the patient is trained to produce sounds correctly, using the correct pronunciation and articulatory movements of the reference speaker as a model. The investigators will compare patients who will follow a classical speech and language therapy rehabilitation program followed by an 'enriched' rehabilitation program including rehabilitation based on sensory-motor interaction associated with speech and language therapy, and vice versa. In order to judge the favorable effect of the rehabilitation program including sensory-motor integration, the following measures will be considered: (a) language skills, (b) phonemic quality, (c) inner speech abilities and (d) cognitive function. Brain language networks will be evaluated with neuroimaging.","post-stroke aphasia non-fluent aphasia speech rehabilitation neuroimaging neural reorganization recovery","Interventional","Inclusion Criteria: patients with late sub-acute and chronic post-stroke (> 4 months) non-fluent aphasia after lesion in the dominant hemisphere for language native speakers of French @@ -1780,7 +1761,7 @@ satisfying all criteria for the MRI examination Exclusion Criteria: patients with comprehension deficits, hemi-spatial neglect or upper limb apraxia","No","55 Years","All","Grenoble","38043",NA,NA,"France",1,"no",5.735782,45.18756,2022-05-05 -"74",87,"Effects of Transcranial Direct Current Stimulation (tDCS) on Language","Stroke Aphasia","December 1, 2019","NCT04166513","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). +"73",87,"Effects of Transcranial Direct Current Stimulation (tDCS) on Language","Stroke Aphasia","December 1, 2019","NCT04166513","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). This study will examine the effects of tDCS during speech therapy to further examine which method or methods is best for patient recovery. Patients enrolled in the study will undergo language testing that covers a broad range of language functions. Functional Magnetic Resonance Imaging (fMRI) will be completed before and after speech therapy intervention arms to investigate the neural processes affected by tDCS and speech therapy. @@ -1798,7 +1779,7 @@ Advanced neurodegenerative disease (i.e. Stage 3 Alzheimer's disease) or neurolo Severe psychopathology (e.g. schizophrenia, bipolar disorder, acute major depressive episode) No suspected or diagnosed uncorrectable hearing or vision difficulties, or developmental disabilities (i.e. intellectual disability or learning disability). Contraindications to MRI such as claustrophobia, implanted electronic devices, MRI-incompatible metal in the body, extreme obesity, pregnancy, inability to lie flat, and inability to see or hear stimulus materials","No","18 Years","All","Milwaukee","53226","Wisconsin","Sara Pillay","United States",1,"no",-88.022002,43.04338,2019-12-01 -"75",89,"Intention Treatment for Anomia","Aphasia Stroke","May 24, 2021","NCT04267198","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia). Stroke-induced aphasia results in increased healthcare costs and decreased quality of life. As the population of Veterans continues to age, there will be an increasing number for Veterans living with the aphasia and its consequences. Those Veterans deserve to receive aphasia treatment designed to facilitate the best possible outcomes. In the proposed study, the investigators will investigate optimal treatment intensity and predictors of treatment response for a novel word retrieval treatment. The knowledge the investigators gain will have direct implications for the selecting the right treatment approach for the right Veteran.","Difficulty retrieving words is one of the most common language complaints in individuals with stroke-induced aphasia. The negative consequences related to word retrieval impairment include increased health care costs and decreased quality of life. A variety of treatment approaches exist to improve word retrieval, and most of the treatments result in immediate improvement on trained words. However, long-term improvement and improvement on untrained words or behaviors is less common. Additionally, the investigators currently know very little about optimal treatment administration parameters, and the investigators know even less about predictors of treatment response. To make the best use of the limited clinical resources available for aphasia treatment, and to maximize outcomes for Veterans with aphasia, the investigators must: 1) develop clinically translatable treatments that yield widespread and lasting effects and 2) develop clinically accessible ways of identifying who will acquire benefit from a specific treatment approach. This study takes on these two challenges by investigating dose frequency (massed vs. distributed practice) effects and by identifying the language, cognitive and neural predictors of response to Intention treatment (INT), a novel word retrieval treatment. Specifically, the investigators will address the following aims: +"74",88,"Intention Treatment for Anomia","Aphasia Stroke","May 24, 2021","NCT04267198","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia). Stroke-induced aphasia results in increased healthcare costs and decreased quality of life. As the population of Veterans continues to age, there will be an increasing number for Veterans living with the aphasia and its consequences. Those Veterans deserve to receive aphasia treatment designed to facilitate the best possible outcomes. In the proposed study, the investigators will investigate optimal treatment intensity and predictors of treatment response for a novel word retrieval treatment. The knowledge the investigators gain will have direct implications for the selecting the right treatment approach for the right Veteran.","Difficulty retrieving words is one of the most common language complaints in individuals with stroke-induced aphasia. The negative consequences related to word retrieval impairment include increased health care costs and decreased quality of life. A variety of treatment approaches exist to improve word retrieval, and most of the treatments result in immediate improvement on trained words. However, long-term improvement and improvement on untrained words or behaviors is less common. Additionally, the investigators currently know very little about optimal treatment administration parameters, and the investigators know even less about predictors of treatment response. To make the best use of the limited clinical resources available for aphasia treatment, and to maximize outcomes for Veterans with aphasia, the investigators must: 1) develop clinically translatable treatments that yield widespread and lasting effects and 2) develop clinically accessible ways of identifying who will acquire benefit from a specific treatment approach. This study takes on these two challenges by investigating dose frequency (massed vs. distributed practice) effects and by identifying the language, cognitive and neural predictors of response to Intention treatment (INT), a novel word retrieval treatment. Specifically, the investigators will address the following aims: Aim 1: To investigate dose frequency effects on maintenance and generalization of INT gains. Outcome measure: Word retrieval accuracy for trained and untrained words. @@ -1817,7 +1798,7 @@ Exclusion Criteria: Severe apraxia of speech or dysarthria Clinically significant depression For MRI safety: implanted medical devices, metal in the body and claustrophobia.","No","21 Years","All","Decatur","30033-4004","Georgia",NA,"United States",1,"no",-84.296069,33.773758,2021-05-24 -"76",90,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. +"75",90,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. All enrolled participants will be assessed on their mood, past music experience and music genre preference (music therapy assessment). They will complete the abridged Beck (BDI-2-fastscreen) questionnaire, the stoke and aphasia quality of life scale; a Likert which measures distress; the Western Aphasia Battery (WAB); the NIH Stroke Scale (SS); the Figely compassion scale; and the driving scene test (Stern and White); and the Rankin. In additional we will take saliva samples from all participants to measure hormone levels. @@ -1828,7 +1809,7 @@ Stroke victim, regardless of level of stroke Exclusion Criteria: None","No","18 Years","All","New York","10003","New York","Joanne Loewy","United States",1,"no",-73.953275,40.7898205,2014-04-04 -"77",97,"Home Program Practice for People With Language Disorders After Stroke","Aphasia Stroke","January 22, 2021","NCT04543084","Duquesne University Pittsburgh Pennsylvania United States","Duquesne University","Recruiting","Logbooks are one of the most commonly used methods to both support and track adherence in research studies. This study will look at using logbooks to support adherence to reading practice for individuals with post-stroke aphasia. It is thought that using a logbook will increase practice time.",NA,"","Interventional","Inclusion Criteria: +"76",97,"Home Program Practice for People With Language Disorders After Stroke","Aphasia Stroke","January 22, 2021","NCT04543084","Duquesne University Pittsburgh Pennsylvania United States","Duquesne University","Recruiting","Logbooks are one of the most commonly used methods to both support and track adherence in research studies. This study will look at using logbooks to support adherence to reading practice for individuals with post-stroke aphasia. It is thought that using a logbook will increase practice time.",NA,"","Interventional","Inclusion Criteria: at least 6 months post left hemisphere stroke with a diagnosis of aphasia must have self-reported interest in working to improve reading comprehension @@ -1840,7 +1821,7 @@ Exclusion Criteria: significant visual or hearing impairment as determined by ""aphasia-friendly"" and age-appropriate screening actively receiving speech-language pathology services in which computerized or reading comprehension home practice activities are assigned/requested severe auditory comprehension impairment that limits understanding of one-step directions (i.e., Western Aphasia Battery-Revised sequential commands subtest score below 8).","No","18 Years","All","Pittsburgh","15228","Pennsylvania",NA,"United States",1,"no",-79.991974,40.4375005,2021-01-22 -"78",98,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: +"77",98,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: Stroke Survivors: @@ -1865,7 +1846,7 @@ Additional Exclusion Criteria for MRIs: Pacemaker or magnetic metal in the body that is not MRI compatible Pregnancy Claustrophobia","Accepts Healthy Volunteers","18 Years","All","Washington","20057","District of Columbia",NA,"United States",1,"no",-77.078807,38.911961,2018-11-01 -"79",100,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: +"78",100,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: Diagnosis of aphasia secondary to stroke and presence of naming deficits (at least 20% errors on the Boston Naming Test or Hopkins Action Naming Assessment) Capable of giving informed consent or indicating another to provide informed consent @@ -1879,7 +1860,7 @@ Lack of English proficiency (by self/legally authorized representative report) Prior history of neurologic disease affecting the brain (e.g., brain tumor, multiple sclerosis, traumatic brain injury) other than stroke Prior history of severe psychiatric illness, developmental disorders or intellectual disability (e.g., PTSD, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders) Uncorrected severe visual loss or hearing loss by self-report and medical records","No","18 Years","All","Baltimore","21287","Maryland",NA,"United States",1,"no",-76.6204945,39.3289375,2023-05-31 -"80",102,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. +"79",102,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. However, language processes are not determined solely by local neural activity at a single site, but rather by the interaction between neural networks. This is because a large cortical network is involved in language processes and, therefore, the same language disorder may result from lesions at different locations in this network. @@ -1905,7 +1886,7 @@ Impaired alertness or delirium Severe co-morbidity affecting speech Contraindication to tDCS: pregnant women, patients with active implants such as pacemakers or cochlear implants, patients with one or more seizures, metal objects in the brain Occurrence of a new stroke during the study protocol.","No","18 Years","All","Geneva","1211","GE","Adrian Guggisberg","Switzerland",1,"no",6.1486155,46.1937405,2022-10-24 -"81",108,"Prism Adaptation in Left Brain Stroke","Aphasia Spatial Neglect Stroke","February 15, 2021","NCT04387162","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Of the 15,000 Veterans who are hospitalized for stroke each year more than half experience spatial and motor impairments and pain. Spatial-motor-sensory problems limit functioning and independence, which is costly to Veterans, their families, and society. Currently, spatial-motor-sensory problems are targeted using different treatments. However, there is a treatment that has shown promise in simultaneously targeting spatial function, motor function and pain in right-brain stroke. The investigators propose to investigate the feasibility of using adapted spatial-motor sensory assessment and treatment procedures for Veterans with left-brain stroke who have language and cognitive impairment. The next step will be to conduct a large-scale study focused on this multi-target treatment for more efficient and effective stroke rehabilitation. The investigators expect this line of research to increase functioning, independence and quality of life in Veteran stroke survivors.","The functional disability experienced by Veterans after stroke, and the limited rehabilitation resources available, highlight the importance of identifying feasible treatments acting on more than one recovery target. Currently, there are separate and modality-specific treatment pathways for cognitive and motor impairments. These modality-specific treatment pathways lead to fragmentation of care, and under-identification and under-treatment of invisible disabilities, such as spatial neglect, aphasia and pain. The result is longer hospital stays, greater risk of falls, and poor functional outcomes. Employing a treatment that simultaneously addresses multiple targets will ensure that the investigators provide the needed care for >50% of post-stroke Veterans who have both visible and invisible disabilities, during the critical post-acute period of recovery. +"80",108,"Prism Adaptation in Left Brain Stroke","Aphasia Spatial Neglect Stroke","February 15, 2021","NCT04387162","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Of the 15,000 Veterans who are hospitalized for stroke each year more than half experience spatial and motor impairments and pain. Spatial-motor-sensory problems limit functioning and independence, which is costly to Veterans, their families, and society. Currently, spatial-motor-sensory problems are targeted using different treatments. However, there is a treatment that has shown promise in simultaneously targeting spatial function, motor function and pain in right-brain stroke. The investigators propose to investigate the feasibility of using adapted spatial-motor sensory assessment and treatment procedures for Veterans with left-brain stroke who have language and cognitive impairment. The next step will be to conduct a large-scale study focused on this multi-target treatment for more efficient and effective stroke rehabilitation. The investigators expect this line of research to increase functioning, independence and quality of life in Veteran stroke survivors.","The functional disability experienced by Veterans after stroke, and the limited rehabilitation resources available, highlight the importance of identifying feasible treatments acting on more than one recovery target. Currently, there are separate and modality-specific treatment pathways for cognitive and motor impairments. These modality-specific treatment pathways lead to fragmentation of care, and under-identification and under-treatment of invisible disabilities, such as spatial neglect, aphasia and pain. The result is longer hospital stays, greater risk of falls, and poor functional outcomes. Employing a treatment that simultaneously addresses multiple targets will ensure that the investigators provide the needed care for >50% of post-stroke Veterans who have both visible and invisible disabilities, during the critical post-acute period of recovery. Prism adaptation treatment (PAT) is a 10-day regimen reported to be inexpensive, replicable and effective for treatment of spatial neglect, and studies have demonstrated that it also enhances everyday activities and motor recovery and reduces chronic post-stroke pain in patients with right brain stroke. Additionally, brain mapping methods have shown that in patients with right brain stroke, those with frontal lesions respond optimally to PAT. No studies have investigated PAT in left-brain stroke patients with language and cognitive impairment. To address this research gap, the investigators will address the following aims: @@ -1924,7 +1905,7 @@ able to provide informed consent to participate, using aphasia-accessible proces Exclusion Criteria: History of brain conditions other than left brain stroke, including clinical right brain pathology.","No","18 Years","All","Decatur","30033-4004","Georgia",NA,"United States",1,"no",-84.296069,33.773758,2021-02-15 -"82",113,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: +"81",113,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: Posterior cortical atrophy - a version of Alzheimer's disease with vision difficulties Logopenic variant primary progressive aphasia - a version of Alzheimer's disease with language difficulties @@ -1958,7 +1939,7 @@ Conditions precluding entry into the scanners (e.g. morbid obesity, claustrophob Exposure to research related radiation in the past year that, when combined with this study, would place subjects above the allowable limits. Participation in the last year in a clinical trial for a disease modifying drug for AD. Taking immunosuppressive medication (e.g., glucocorticoids, cytostatics, antibodies, drugs acting on immunophilins, interferons, tumor necrosis factor inhibitors). Nonsteroidal anti-inflammatory drugs (NSAIDs) are not exclusionary.","Accepts Healthy Volunteers","50 Years","All","New York","10032","New York","James M Noble, MD, MS, CPH, FAAN","United States",1,"no",-73.9622875,40.807223,2020-11-17 -"83",166,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: +"82",166,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: to evaluate the residual neuroplastic processes in DOC state related to music exposure to determine the putative modulation of the aforementioned processes and the clinical outcome of DOC patients by non-pharmacological strategies, i.e., electric (tDCS) and music stimulation @@ -1979,9 +1960,9 @@ No hystory of psychiatric disease Previous stroke use of alcohol and drugs premorbid dementia","No","18 Years","All","Bari","70025","Ba","Simona Spaccavento","Italy",1,"no",16.862029,41.125784,2022-09-01 -"84",NA,"Functional reorganization of the language and domain-general multiple demand systems in aphasia",NA,"March 1, 2022","manual1","Boston, MA","Boston University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Boston",NA,"Massachusetts","Swathi Kiran",NA,NA,"no",-71.058291,42.360253,2022-03-01 -"85",NA,"Characterizing inner speech in aphasia",NA,"March 9, 2022","manual2","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 -"86",NA,"Inner speech as a naming therapy predictor in aphasia",NA,"March 9, 2022","manual3","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 -"87",NA,"Measuring and understanding the experience of post-traumatic growth in aphasia",NA,"March 9, 2022","manual4","Reno, NV","University of Nevada Reno",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Reno",NA,"Nevada","Tami Brancamp",NA,NA,"Online",-119.812658,39.526121,2022-03-09 -"88",NA,"Reading in Aphasia",NA,"January 1, 2020","manual5","Atlanta, GA","Georgia State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Atlanta",NA,"GA","Rachael Harrington",NA,NA,"Online",-84.390264,33.748992,2020-01-01 -"89",NA,"Assessment of anomia: Improving efficiency and utility using item response theory",NA,"August 31, 2020","manual6","Portland, OR","Portland State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Portland",NA,"OR","Gerasimos Fergadiotis",NA,NA,"no",-122.674195,45.520247,2020-08-31 +"83",NA,"Functional reorganization of the language and domain-general multiple demand systems in aphasia",NA,"March 1, 2022","manual1","Boston, MA","Boston University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Boston",NA,"Massachusetts","Swathi Kiran",NA,NA,"no",-71.058291,42.360253,2022-03-01 +"84",NA,"Characterizing inner speech in aphasia",NA,"March 9, 2022","manual2","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 +"85",NA,"Inner speech as a naming therapy predictor in aphasia",NA,"March 9, 2022","manual3","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 +"86",NA,"Measuring and understanding the experience of post-traumatic growth in aphasia",NA,"March 9, 2022","manual4","Reno, NV","University of Nevada Reno",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Reno",NA,"Nevada","Tami Brancamp",NA,NA,"Online",-119.812658,39.526121,2022-03-09 +"87",NA,"Reading in Aphasia",NA,"January 1, 2020","manual5","Atlanta, GA","Georgia State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Atlanta",NA,"GA","Rachael Harrington",NA,NA,"Online",-84.390264,33.748992,2020-01-01 +"88",NA,"Assessment of anomia: Improving efficiency and utility using item response theory",NA,"August 31, 2020","manual6","Portland, OR","Portland State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Portland",NA,"OR","Gerasimos Fergadiotis",NA,NA,"no",-122.674195,45.520247,2020-08-31 diff --git a/docs/data/contact.rds b/docs/data/contact.rds index 584f95e22b8cca485e0b765ea7c5779013fbcd63..a8dd29feac6ecd38d76d4533955c253c67921cfc 100644 GIT binary patch delta 171 zcmcZ|vLJYZEMxLUIRnPcHH_`d!ivuMr9~xqsg-)Z$-(8RsX*3dQP%5hjLDPVa$nv2 ziYI_c+1$`VQ^DB4Lf6v7)PRA7fs=uOflmWPbaO2KUKYmW&C()LjGNO$RhWf^UI_?oc!e5a%(oPm9GVIH*2fCV4AG1sW;g`lVx(K=1#`BllirL0E_iBZU6uP delta 311 zcmZ1wd^==+*{?BrNjWKod0q&~`rUr((W(LN(h6aX~P;+=7 zVum0w!_B=s5lqTPhDMqS7Dgrt7RF{UWqcYaqMJGR_p&giZayX~#i%71kY7}inW*3l zbf%6%K!%23hq_ZC2c+EI_a)_o60L!XVCjbBd diff --git a/docs/data/data_dt.rds b/docs/data/data_dt.rds index 34c31b78167eb8ba4ed3f4f8dd13134993ab9f46..99e0950dee8aa23364b2bea0437bb69efae36c6c 100644 GIT binary patch delta 110 zcmZ3|$~duwae^#k#74QFOq+w5_e(NHOcs{)+MFu8iV4URP*}cszrr&XAoGl>{Nx*| z!a&@%xlnCCD`UiFLmfZH$%Urcn@{LUa0B@dEnJx=8`x}MTrv5f%`Tw899t!p$)_Br J0RP;Lk diff --git a/docs/data/study_info.rds b/docs/data/study_info.rds index 5b7e153dfeaa8549259d6f7060b45cde016f5d5f..692d0b631d98d8ecdeb12c8208d193dcb853aa28 100644 GIT binary patch delta 456 zcmY+;JxGF46b4}LJ!R03iuF+lSt;gFR8*Kne2Pm21wmO&CJhY{6osSoLqBWcaEC-N z5G5R;i}uz?*M&Fbd-^1=BDCewc%KScp7(n5x;B z!nI90HZe77Y|2E}nvI&GOje^^vTSKzmf9+mzt%_XyX~z83!hFW60M~>X4a~`%Q4ie zPlJKOf{)39k3Z}&Rc7w^K8prh^wM+Bk7}7JvN;|S?mQ36?HmtMxzsTDk>_cX{CVeg zbYeYD1HvDtSy7Brx5Tl*5s#dZTdX8#LcS!Zhp?7N(km0eB<+cV6uB^SlcHTYmL>!K yCIcBNG2Gru$}+KjN_ycqqn%1}PT@*Ze!jV&-T#SE(&E2Fs#oOV>{f)XY4Q&Wmx46_ delta 3026 zcmZ`*?{6H%8NS`g4>%gf)OH{UoJj-3C+_UniG!g~$Ak){O{n8qEv-bA@$TH+*n2yh znc0|&KrX0lqzaLk1Ez=+SqLFSD^X#j>xUARuTiP^(5h-bfcg)VR%%tX5^A5>J)fOR zi1OO&*_rpp^FGfz`@>KBKKyszrMtZ8)!~Ep6bpsImtebKeXxGmt*`;uAZ!S>XLWJk z1N-o>ANCd40odKJdtnD*W!M<(5NsTF7&Zla5ccrum3`j#RzI2crq_qPA-{6uL?dB= zp|VOJQ!-8HEK^1VB4I|znBxCTm_|m^?+R02zni?%?@hPXhG^@vf#)AQK9kg$7OYHX zg0rbmJfzD_-1^Uf;nsTx?px>kezOzFt{v2*b@AXO`_I=&f9qF!@5S0T?z{Zu zUEYcLI;Tmh5~+D>_JzS?{3+HDF{cLWqFY@pt1juSj^))YqdLm+YV2Cc8?=W~|CR&V zusCEYq>17cJW>QP6{a=Uy1`=yTkE$!8@y>mC!7cMvVC0mcdm>{MVFN@BCeH2DbkB+ zH*O3lmqip&W(_qhWdp$?7tqVuvuzv2G=fA6Sn=lxtUi0?7LA@^;zew7=7O7yZGn zHIhg+DWho&-wGj`l^_x^GGAaCRFSE1EORjC#TrRj2sDJNszrak$G*Pb-?0L015w2> zCK}oi)#P=iA-pT}S<;Z>MAmfFc%x3EE+x-#O-IH{G!j)X<{Bn2O&gr))KPe$3238g zMe#%`Ll@7cfEmTc3=9VpBNHWnhk)mhI@T-Q1ba}UJzfoZYaDIhI${Q)Ix&$JAFYj+ z?dc2N9y@);+g^420YNB#3e?LuP|CojBZo^g;i@WCBWoiR8Y73yH#~MzFi4u}K;m?7 z9;~~|{^NdckQ9rv_V1y8$I6k)Bq|Hh=rCmwbuJv~x+KiA#1_y6@3-h6(*`s$mIiz7=n9cE}c2Y*++ous}%-nqV3V#K{8aOx_#f z5P-Uq1Uk`CteZkTTF&%emBH>5bdH_oz)b+X+5WxPx1Z)p%!boLS>ky~h?L+7!xeq* z0OGpwh2b~H+sbj7pe}5l;{j@<^BV-EBgbdv=1X*0swG|L+&EfnGyqsYa#a@O^F14~ zPFxwd*tjwK=n`+jL8vj)a=PP~gTrO-c(vF7)(T7lj4mF|o|BPNX@JDs4#QLp!E-M; z$7Idv0ej%AGh{pOt4cQDJF8^m5ze)nPdLq@(b8tocJ6{Vbb3o=&Ml8??sh`%q0m8^ z=?$)G82woqNV_|@iX4Q$_?5UGQ;wTzrayf6!E|*-$i9Hi<;;0 z2TF0g$%Yw1xyzZAl#IiuXlo6k^~x`HmjO+jW4SSXa^bjaCMrfiu!+R{bRD#RYkIfa<&V6+ z5zO@**(hD;8P1q>Jt8TWv)*4jAoKZn{cyi-{HmYYD?>ObNBUdIXbd;jfz-&?TWb~40fP}=wuZE~g{ zUPWbuubHAlsv*^aa9;`%cU5+);a*@%9DAzt>v1g-x?X%#uv(1kHoM2NZ;uLYcSq9v z+oSj$`|KDQ*q>H6oOHN>!Ip8b^WmW_yM^3#=5a}J7aFOWE=W)pQCOEUr1|HF%ddMM zgu=OW!;9 - - + + @@ -2283,7 +2283,7 @@ color: var(--hover-color, white); } - + diff --git a/docs/list_view.html b/docs/list_view.html index f55e6b0..e2af8a4 100644 --- a/docs/list_view.html +++ b/docs/list_view.html @@ -456,8 +456,8 @@ - - + + @@ -2280,7 +2280,7 @@ color: var(--hover-color, white); } - + @@ -3124,126 +3124,6 @@

-
- -


-
-
- -

Copy these email(s) into your email:

-

pcarr@uams.edu, drmoser@uams.edu

-

Copy this email template into your email:

-
-Dear Portia Carr and Dana Moser,

-I found your research on aphasiaresearch.org.
-I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
-The best way to contact me is:
-  Caregiver: [Insert your phone / email]
-  Person with aphasia: [Insert your phone / email]
-Thank you for doing this research.

-Sincerely,
-[Insert your name]

-
- -
- -
-
-
-

-Impact of Group Participation on Adults With Aphasia -

-
-Principle Investigator: NA -
-
-Institution: University of Arkansas -
-
-Country: United States -
-
-City: Little Rock, Arkansas -
-
-Brief Description: -
-The purpose of the study is to examine the impact of group participation on adults with aphasia. Participants will complete a standard pre-and post-assessment of language abilities (speech, comprehension, reading, and/or writing). Then participants will attend 90-minute weekly reading group sessions during an academic semester. -
-
-Inclusion Criteria: -
-
  • -Age 18 years or older -
  • -Pre-morbid proficient speaker of English -
  • -Diagnosis of adult-onset aphasia -
  • -Vision and hearing sufficient to complete assessments
    -
    • -Exlcusion Criteria: -
    -
  • -No history of childhood speech or language difficulties -
  • -No history of major psychiatric illness, cognitive impairment, or neurological disorders such as seizures -
    • -
    -Contact Information: -
    - - - - - - - - - - - - - - - - - - - - - - - - - -
    -Dana Moser, Ph.D -
    -Phone: - -501-603-1019 -
    -Email: - - -
    -Portia Carr, Ph.D -
    -Phone: - -501-601-1011 -
    -Email: - - -
    -
    - -
    -


    @@ -3253,7 +3133,7 @@

    Copy these email(s) into your email:

    svallilarohter@mghihp.edu, mlnicholas@mghihp.edu

    Copy this email template into your email:

    -
    +
    Dear Sofia Vallila Rohter and Marjorie Nicholas,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -3266,7 +3146,7 @@

    Copy this email template into your email:

    - +
    @@ -3380,7 +3260,7 @@

    Copy these email(s) into your email:

    cute@musc.edu, krajeck@musc.edu

    Copy this email template into your email:

    -
    +
    Dear Stephanie Cute and Kelly Krajeck,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -3393,7 +3273,7 @@

    Copy this email template into your email:

    - +
    @@ -3527,7 +3407,7 @@

    Copy these email(s) into your email:

    blanca.fuentes@salud.madrid.org, elena.decelis.ruiz@idipaz.es

    Copy this email template into your email:

    -
    +
    Dear Blanca Fuentes Gimeno and Elena de Celis Ruiz,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -3540,7 +3420,7 @@

    Copy this email template into your email:

    - +
    @@ -3645,7 +3525,7 @@

    Copy these email(s) into your email:

    pytsai@vghtpe.gov.tw

    Copy this email template into your email:

    -
    +
    Dear Po-Yi Tsai,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -3658,7 +3538,7 @@

    Copy this email template into your email:

    - +
    @@ -3756,7 +3636,7 @@

    Copy these email(s) into your email:

    tbulut@medipol.edu.tr, tbulut@medipol.edu.tr

    Copy this email template into your email:

    -
    +
    Dear Talat Bulut and MEDKOM,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -3769,7 +3649,7 @@

    Copy this email template into your email:

    - +
    @@ -3897,7 +3777,7 @@

    Copy these email(s) into your email:

    kpolanowska@ipin.edu.pl, iwanski@ipin.edu.pl

    Copy this email template into your email:

    -
    +
    Dear Katarzyna E Polanowska and Szczepan Iwański,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -3910,7 +3790,7 @@

    Copy this email template into your email:

    - +
    @@ -4033,7 +3913,7 @@

    Copy these email(s) into your email:

    olsonac@bham.ac.uk

    Copy this email template into your email:

    -
    +
    Dear Andrew Olson,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -4046,7 +3926,7 @@

    Copy this email template into your email:

    - +
    @@ -4124,7 +4004,7 @@

    Copy these email(s) into your email:

    lee1704@purdue.edu, lee1704@purdue.edu

    Copy this email template into your email:

    -
    +
    Dear Jiyeon Lee and Jiyeon Lee,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -4137,7 +4017,7 @@

    Copy this email template into your email:

    - +
    @@ -4252,7 +4132,7 @@

    Copy these email(s) into your email:

    claudia.repetto@unicatt.it, alice.cancer@unicatt.it

    Copy this email template into your email:

    -
    +
    Dear Claudia Repetto and Alice Cancer,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -4265,7 +4145,7 @@

    Copy this email template into your email:

    - +
    @@ -4376,7 +4256,7 @@

    Copy these email(s) into your email:

    r-behroozmand@sc.edu

    Copy this email template into your email:

    -
    +
    Dear Roozbeh Behroozmand,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -4389,7 +4269,7 @@

    Copy this email template into your email:

    - +
    @@ -4467,7 +4347,7 @@

    Copy these email(s) into your email:

    e.meier@northeastern.edu, s.intille@northeastern.edu

    Copy this email template into your email:

    -
    +
    Dear Erin L Meier and Stephen Intille,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -4480,7 +4360,7 @@

    Copy this email template into your email:

    - +
    @@ -4587,7 +4467,7 @@

    Copy these email(s) into your email:

    mary.sullivan@va.gov, alyssa.autenreith@va.gov

    Copy this email template into your email:

    -
    +
    Dear Mary Sullivan and Alyssa Autenreith,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -4600,7 +4480,7 @@

    Copy this email template into your email:

    - +
    @@ -4719,7 +4599,7 @@

    Copy these email(s) into your email:

    nmartin@temple.edu, reillyj@temple.edu

    Copy this email template into your email:

    -
    +
    Dear Nadine Martin and Jamie Reilly,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -4732,7 +4612,7 @@

    Copy this email template into your email:

    - +
    @@ -4867,7 +4747,7 @@

    Copy these email(s) into your email:

    samuel.cason@pennmedicine.upenn.edu, hbc@pennmedicine.upenn.edu

    Copy this email template into your email:

    -
    +
    Dear Samuel Cason and Principal Investigator,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -4880,7 +4760,7 @@

    Copy this email template into your email:

    - +
    @@ -4993,7 +4873,7 @@

    Copy these email(s) into your email:

    danet.l@chu-toulouse.fr, delrutte.s@chu-toulouse.fr

    Copy this email template into your email:

    -
    +
    Dear Lola Danet and Stéphanie Delrutte,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -5006,7 +4886,7 @@

    Copy this email template into your email:

    - +
    @@ -5127,7 +5007,7 @@

    Copy these email(s) into your email:

    njpaik@snu.ac.kr, bluebelll@naver.com

    Copy this email template into your email:

    -
    +
    Dear Nam-Jong Paik and Ji-Young Lee,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -5140,7 +5020,7 @@

    Copy this email template into your email:

    - +
    @@ -5263,10 +5143,10 @@

    Copy these email(s) into your email:

    -

    aidan.rogers@mountsinai.org, gabriela.rozanski@mountsinai.org

    +

    aidan.rogers@mountsinai.org, Courtney.McSweeney@mountsinai.org

    Copy this email template into your email:

    -
    -Dear Aidan Rogers and Gabriela Rozanski,

    +
    +Dear Aidan Rogers and Courtney McSweeney,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    The best way to contact me is:
    @@ -5278,7 +5158,7 @@

    Copy this email template into your email:

    - +
    @@ -5358,8 +5238,8 @@

    Phone: -
      -
    1. 824 8369 +
        +
      1. 308-9450 @@ -5372,7 +5252,7 @@

        -Gabriela Rozanski +Courtney McSweeney @@ -5380,8 +5260,8 @@

        Phone: -
          -
        1. 824 8369 +
            +
          1. 308-9450 @@ -5389,7 +5269,7 @@

            Email: - + @@ -5411,7 +5291,7 @@

            Copy these email(s) into your email:

            jdrichardson@unm.edu, hhubbard@unm.edu

            Copy this email template into your email:

            -
            +
            Dear Jessica Richardson and Honey Hubbard,

            I found your research on aphasiaresearch.org.
            I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
            @@ -5424,7 +5304,7 @@

            Copy this email template into your email:

            - +

    @@ -5543,7 +5423,7 @@

    Copy these email(s) into your email:

    julio.hpavon@northwestern.edu, lkinsey@sralab.org

    Copy this email template into your email:

    -
    +
    Dear Julio Hernandez Pavon and Laura Kinsey,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -5556,7 +5436,7 @@

    Copy this email template into your email:

    - +
    @@ -5693,7 +5573,7 @@

    Copy these email(s) into your email:

    aphasialab@osu.edu, harnish.18@osu.edu

    Copy this email template into your email:

    -
    +
    Dear Victoria Diedrichs and Stacy M Harnish,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -5706,7 +5586,7 @@

    Copy this email template into your email:

    - +
    @@ -5821,7 +5701,7 @@

    Copy these email(s) into your email:

    blackett@musc.edu

    Copy this email template into your email:

    -
    +
    Dear Principal Investigator,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -5834,7 +5714,7 @@

    Copy this email template into your email:

    - +
    @@ -5930,7 +5810,7 @@

    Copy these email(s) into your email:

    lkinsey@sralab.org

    Copy this email template into your email:

    -
    +
    Dear Laura Kinsey,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -5943,7 +5823,7 @@

    Copy this email template into your email:

    - +
    @@ -6041,7 +5921,7 @@

    Copy these email(s) into your email:

    wangkai1964@126.com, baiyunong1990@163.com

    Copy this email template into your email:

    -
    +
    Dear Kai Wang and Tongjian Bai,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -6054,7 +5934,7 @@

    Copy this email template into your email:

    - +
    @@ -6169,7 +6049,7 @@

    Copy these email(s) into your email:

    earil100@syr.edu

    Copy this email template into your email:

    -
    +
    Dear Ellyn A Riley,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -6182,7 +6062,7 @@

    Copy this email template into your email:

    - +
    @@ -6316,7 +6196,7 @@

    Copy these email(s) into your email:

    Elena.Zevgolatakou@mrc-cbu.cam.ac.uk, Ajay.Halai@mrc-cbu.cam.ac.uk

    Copy this email template into your email:

    -
    +
    Dear Eleni Zevgolatakou and Ajay Halai,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -6329,7 +6209,7 @@

    Copy this email template into your email:

    - +
    @@ -6460,7 +6340,7 @@

    Copy these email(s) into your email:

    lcherney@sralab.org, sameer.ashaie@northwestern.edu

    Copy this email template into your email:

    -
    +
    Dear Leora Cherney and Sameer Ashaie,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -6473,7 +6353,7 @@

    Copy this email template into your email:

    - +
    @@ -6592,7 +6472,7 @@

    Copy these email(s) into your email:

    shauna.zodrow@jefferson.edu

    Copy this email template into your email:

    -
    +
    Dear Shauna Zodrow,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -6605,7 +6485,7 @@

    Copy this email template into your email:

    - +
    @@ -6695,7 +6575,7 @@

    Copy these email(s) into your email:

    claudio.brozzoli@inserm.fr, mallory.augier@gmail.com

    Copy this email template into your email:

    -
    +
    Dear Claudio BROZZOLI and Mallory AUGIER,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -6708,7 +6588,7 @@

    Copy this email template into your email:

    - +
    @@ -6849,7 +6729,7 @@

    Copy these email(s) into your email:

    samargia@d.umn.edu, fencl003@umn.edu

    Copy this email template into your email:

    -
    +
    Dear Sharyl Samargia-Grivette and Sydney Viel,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -6862,7 +6742,7 @@

    Copy this email template into your email:

    - +
    @@ -6986,7 +6866,7 @@

    Copy these email(s) into your email:

    argye@jhmi.edu, md.stockbridge@jhmi.edu

    Copy this email template into your email:

    -
    +
    Dear Argye Hillis-Trupe and Melissa D Stockbridge,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -6999,7 +6879,7 @@

    Copy this email template into your email:

    - +
    @@ -7130,7 +7010,7 @@

    Copy these email(s) into your email:

    agnes.floeel@uni-greifswald.de, nina.unger@uni-greifswald.de

    Copy this email template into your email:

    -
    +
    Dear Agnes Floeel and Nina Unger,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7143,7 +7023,7 @@

    Copy this email template into your email:

    - +
    @@ -7278,7 +7158,7 @@

    Copy these email(s) into your email:

    lzipse@mghihp.edu

    Copy this email template into your email:

    -
    +
    Dear Lauryn Zipse,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7291,7 +7171,7 @@

    Copy this email template into your email:

    - +
    @@ -7379,7 +7259,7 @@

    Copy these email(s) into your email:

    ruiqipanedu@163.com

    Copy this email template into your email:

    -
    +
    Dear Ruiqi Pan,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7392,7 +7272,7 @@

    Copy this email template into your email:

    - +
    @@ -7510,7 +7390,7 @@

    Copy these email(s) into your email:

    DRMoser@uams.edu, PSCarr@uams.edu

    Copy this email template into your email:

    -
    +
    Dear Dana Moser and Portia Carr,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7523,7 +7403,7 @@

    Copy this email template into your email:

    - +
    @@ -7642,7 +7522,7 @@

    Copy these email(s) into your email:

    sdrane@mcw.edu

    Copy this email template into your email:

    -
    +
    Dear Samantha Drane,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7655,7 +7535,7 @@

    Copy this email template into your email:

    - +
    @@ -7765,7 +7645,7 @@

    Copy these email(s) into your email:

    marion.fossard@unine.ch, celia.ericson@unine.ch

    Copy this email template into your email:

    -
    +
    Dear Marion Fossard and Célia Ericson,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7778,7 +7658,7 @@

    Copy this email template into your email:

    - +
    @@ -7894,7 +7774,7 @@

    Copy these email(s) into your email:

    claire.honeycutt@asu.edu

    Copy this email template into your email:

    -
    +
    Dear Claire F Honeycutt,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -7907,7 +7787,7 @@

    Copy this email template into your email:

    - +
    @@ -7999,7 +7879,7 @@

    Copy these email(s) into your email:

    min.wong@polyu.edu.hk, faisal.n.baig@polyu.edu.hk

    Copy this email template into your email:

    -
    +
    Dear Min Ney WONG and Faisal N Baig,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8012,7 +7892,7 @@

    Copy this email template into your email:

    - +
    @@ -8135,7 +8015,7 @@

    Copy these email(s) into your email:

    charlotta.saldert@neuro.gu.se, francesca.longoni@neuro.gu.se

    Copy this email template into your email:

    -
    +
    Dear Charlotta Saldert and Francesca Longoni,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8148,7 +8028,7 @@

    Copy this email template into your email:

    - +
    @@ -8261,7 +8141,7 @@

    Copy these email(s) into your email:

    tmontagnon@chu-grenoble.fr

    Copy this email template into your email:

    -
    +
    Dear University Hospital,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8274,7 +8154,7 @@

    Copy this email template into your email:

    - +
    @@ -8358,7 +8238,7 @@

    Copy these email(s) into your email:

    sdrane@mcw.edu

    Copy this email template into your email:

    -
    +
    Dear Samantha Drane,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8371,7 +8251,7 @@

    Copy this email template into your email:

    - +
    @@ -8459,7 +8339,7 @@

    Copy these email(s) into your email:

    amy.rodriguez@va.gov, Laura.Britan_Lang@va.gov

    Copy this email template into your email:

    -
    +
    Dear Amy D Rodriguez and Laura Britan Lang,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8472,7 +8352,7 @@

    Copy this email template into your email:

    - +
    @@ -8587,7 +8467,7 @@

    Copy these email(s) into your email:

    joanne.loewy@mountsinai.org

    Copy this email template into your email:

    -
    +
    Dear Joanne Loewy,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8600,7 +8480,7 @@

    Copy this email template into your email:

    - +
    @@ -8678,7 +8558,7 @@

    Copy these email(s) into your email:

    donosobrowne@duq.edu

    Copy this email template into your email:

    -
    +
    Dear Elena V Donoso Brown,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8691,7 +8571,7 @@

    Copy this email template into your email:

    - +
    @@ -8779,7 +8659,7 @@

    Copy these email(s) into your email:

    al1579@georgetown.edu, ehl4@georgetown.edu

    Copy this email template into your email:

    -
    +
    Dear Alycia Laks and Elizabeth Lacey,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8792,7 +8672,7 @@

    Copy this email template into your email:

    - +
    @@ -8911,7 +8791,7 @@

    Copy these email(s) into your email:

    argye@jhmi.edu, md.stockbridge@jhmi.edu

    Copy this email template into your email:

    -
    +
    Dear Argye E Hillis and Melissa D Stockbridge,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -8924,7 +8804,7 @@

    Copy this email template into your email:

    - +
    @@ -9037,7 +8917,7 @@

    Copy these email(s) into your email:

    Adrian.Guggisberg@insel.ch

    Copy this email template into your email:

    -
    +
    Dear Adrian G Guggisberg,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9050,7 +8930,7 @@

    Copy this email template into your email:

    - +
    @@ -9149,7 +9029,7 @@

    Copy these email(s) into your email:

    amy.rodriguez@va.gov, Laura.Britan_Lang@va.gov

    Copy this email template into your email:

    -
    +
    Dear Amy D Rodriguez and Laura Britan Lang,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9162,7 +9042,7 @@

    Copy this email template into your email:

    - +
    @@ -9273,7 +9153,7 @@

    Copy these email(s) into your email:

    gfz2102@cumc.columbia.edu, eg2972@cumc.columbia.edu

    Copy this email template into your email:

    -
    +
    Dear Galen Ziaggi and Elena M. Golub,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9286,7 +9166,7 @@

    Copy this email template into your email:

    - +
    @@ -9413,7 +9293,7 @@

    Copy these email(s) into your email:

    simona.spaccavento@icsmaugeri.it

    Copy this email template into your email:

    -
    +
    Dear Simona Spaccavento,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9426,7 +9306,7 @@

    Copy this email template into your email:

    - +
    @@ -9524,7 +9404,7 @@

    Copy these email(s) into your email:

    aphasiaresearchlaboratory@gmail.com

    Copy this email template into your email:

    -
    +
    Dear Swathi Kiran,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9537,7 +9417,7 @@

    Copy this email template into your email:

    - +
    @@ -9604,7 +9484,7 @@

    Copy these email(s) into your email:

    bcstark@iu.edu

    Copy this email template into your email:

    -
    +
    Dear Brielle C. Stark,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9617,7 +9497,7 @@

    Copy this email template into your email:

    - +
    @@ -9684,7 +9564,7 @@

    Copy these email(s) into your email:

    bcstark@iu.edu

    Copy this email template into your email:

    -
    +
    Dear Brielle C. Stark,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9697,7 +9577,7 @@

    Copy this email template into your email:

    - +
    @@ -9764,7 +9644,7 @@

    Copy these email(s) into your email:

    tbrancamp@med.unr.edu

    Copy this email template into your email:

    -
    +
    Dear Tami Brancamp,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9777,7 +9657,7 @@

    Copy this email template into your email:

    - +
    @@ -9844,7 +9724,7 @@

    Copy these email(s) into your email:

    rharrington2@gsu.edu

    Copy this email template into your email:

    -
    +
    Dear Rachael Harrington,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9857,7 +9737,7 @@

    Copy this email template into your email:

    - +
    @@ -9924,7 +9804,7 @@

    Copy these email(s) into your email:

    aphasialab@pdx.edu

    Copy this email template into your email:

    -
    +
    Dear Stacey Steel,

    I found your research on aphasiaresearch.org.
    I have aphasia and I'm interested in learning more about the study. I think I may meet the study criteria.
    @@ -9937,7 +9817,7 @@

    Copy this email template into your email:

    - +
    diff --git a/docs/recent.html b/docs/recent.html index 9af3fb9..4dc4695 100644 --- a/docs/recent.html +++ b/docs/recent.html @@ -456,8 +456,8 @@ - - + + @@ -2280,7 +2280,7 @@ color: var(--hover-color, white); } - + @@ -2373,8 +2373,8 @@

    Recently added research studies

    -
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    Online research studies

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b/docs/site_libs/font-awesome-6.4.2/css/all.css similarity index 99% rename from docs/site_libs/font-awesome-6.4.0/css/all.css rename to docs/site_libs/font-awesome-6.4.2/css/all.css index 9615471..bdb6e3a 100644 --- a/docs/site_libs/font-awesome-6.4.0/css/all.css +++ b/docs/site_libs/font-awesome-6.4.2/css/all.css @@ -1,5 +1,5 @@ /*! - * Font Awesome Free 6.4.0 by @fontawesome - https://fontawesome.com + * Font Awesome Free 6.4.2 by @fontawesome - https://fontawesome.com * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) * Copyright 2023 Fonticons, Inc. */ @@ -6550,6 +6550,9 @@ readers do not read off random characters that represent icons */ .fa-edge:before { content: "\f282"; } +.fa-threads:before { + content: "\e618"; } + .fa-napster:before { content: "\f3d2"; } @@ -6718,6 +6721,9 @@ readers do not read off random characters that represent icons */ .fa-scribd:before { content: "\f28a"; } +.fa-debian:before { + content: "\e60b"; } + .fa-openid:before { content: "\f19b"; } @@ -6958,6 +6964,9 @@ readers do not read off random characters that represent icons */ .fa-neos:before { content: "\f612"; } +.fa-square-threads:before { + content: "\e619"; } + .fa-hackerrank:before { content: "\f5f7"; } @@ -7300,6 +7309,9 @@ readers do not read off random characters that represent icons */ .fa-erlang:before { content: "\f39d"; } +.fa-x-twitter:before { + content: "\e61b"; } + .fa-cotton-bureau:before { content: "\f89e"; } @@ -7795,6 +7807,9 @@ readers do not read off random characters that represent icons */ .fa-quora:before { content: "\f2c4"; } +.fa-square-x-twitter:before { + content: "\e61a"; } + .fa-reacteurope:before { content: "\f75d"; } diff --git a/docs/site_libs/font-awesome-6.4.0/css/all.min.css b/docs/site_libs/font-awesome-6.4.2/css/all.min.css similarity index 85% rename from docs/site_libs/font-awesome-6.4.0/css/all.min.css rename to docs/site_libs/font-awesome-6.4.2/css/all.min.css index 9411846..6604a06 100644 --- a/docs/site_libs/font-awesome-6.4.0/css/all.min.css +++ b/docs/site_libs/font-awesome-6.4.2/css/all.min.css @@ -1,9 +1,9 @@ /*! - * Font Awesome Free 6.4.0 by @fontawesome - https://fontawesome.com + * Font Awesome Free 6.4.2 by @fontawesome - https://fontawesome.com * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) * Copyright 2023 Fonticons, Inc. */ .fa{font-family:var(--fa-style-family,"Font Awesome 6 Free");font-weight:var(--fa-style,900)}.fa,.fa-brands,.fa-classic,.fa-regular,.fa-sharp,.fa-solid,.fab,.far,.fas{-moz-osx-font-smoothing:grayscale;-webkit-font-smoothing:antialiased;display:var(--fa-display,inline-block);font-style:normal;font-variant:normal;line-height:1;text-rendering:auto}.fa-classic,.fa-regular,.fa-solid,.far,.fas{font-family:"Font Awesome 6 Free"}.fa-brands,.fab{font-family:"Font Awesome 6 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diff --git a/docs/site_libs/font-awesome-6.4.0/css/v4-shims.css b/docs/site_libs/font-awesome-6.4.2/css/v4-shims.css similarity index 99% rename from docs/site_libs/font-awesome-6.4.0/css/v4-shims.css rename to docs/site_libs/font-awesome-6.4.2/css/v4-shims.css index 8544df2..a85953d 100644 --- a/docs/site_libs/font-awesome-6.4.0/css/v4-shims.css +++ b/docs/site_libs/font-awesome-6.4.2/css/v4-shims.css @@ -1,5 +1,5 @@ /*! - * Font Awesome Free 6.4.0 by @fontawesome - https://fontawesome.com + * Font Awesome Free 6.4.2 by @fontawesome - https://fontawesome.com * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License) * Copyright 2023 Fonticons, Inc. */ diff --git a/docs/site_libs/font-awesome-6.4.0/css/v4-shims.min.css b/docs/site_libs/font-awesome-6.4.2/css/v4-shims.min.css similarity index 99% rename from docs/site_libs/font-awesome-6.4.0/css/v4-shims.min.css rename to docs/site_libs/font-awesome-6.4.2/css/v4-shims.min.css index 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