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sample_geneset.txt
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sample_geneset.txt
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Geneset Gene qvalue
KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS PDHB VARS2 IARS2 PDHA1 PDHA2 LARS LARS2 VARS BCAT1 BCAT2 IARS 0.203046528
KEGG_LYSINE_DEGRADATION SUV39H2 AASDHPPT DLST ALDH1B1 AASDH ALDH2 ACAT2 PLOD2 PLOD1 TMLHE EHMT2 ACAT1 SETD8 HADH SETMAR OGDH HADHA BBOX1 AASS ECHS1 ALDH9A1 ALDH3A2 SUV420H1 SUV39H1 ASH1L SETD1B DOT1L WHSC1 EHHADH OGDHL SETD1A GCDH SUV420H2 SETD7 ALDH7A1 WHSC1L1 EHMT1 SETDB1 AADAT SETD2 SETDB2 PLOD3 NSD1 PIPOX 0.129292888
KEGG_GLYCEROLIPID_METABOLISM MBOAT2 GPAM LIPG DGKZ DGKE DGKD DGKH MBOAT1 GK DGAT2 GK2 GLA ALDH7A1 AGK DAK AGPAT3 AWAT2 AGPAT4 AKR1B1 PNLIPRP2 PNLIPRP1 PNLIP DGAT1 GLYCTK LPL ALDH1B1 DGKQ ALDH2 DGKB DGKG AKR1A1 DGKA PPAP2B LIPC DGKI LCLAT1 AGPAT9 MGLL AGPAT6 ALDH9A1 ALDH3A2 PNPLA3 PPAP2A PPAP2C AGPAT1 AGPAT2 CEL GPAT2 LIPF 0.014208608
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM PEMT PLA2G15 GPD1 GPD1L LPGAT1 GPAM MBOAT2 MBOAT7 CHAT LPCAT1 PTDSS1 ACHE PLA2G3 DGKZ ETNK1 DGKE DGKD PCYT1A DGKH JMJD7-PLA2G4B CHPT1 MBOAT1 PLA2G6 PLA2G2E PLA2G10 LPCAT3 PLA2G2A ETNK2 PLA2G4A PLA2G5 PLA2G12B PLA2G4B PTDSS2 PLA2G2F PCYT2 CDS1 AGPAT3 AGPAT4 PGS1 LYPLA1 PLA2G1B C17orf48 CDIPT DGKQ CDS2 DGKB DGKG PPAP2B DGKA DGKI PHOSPHO1 LCLAT1 TAZ AGPAT9 GNPAT LPCAT4 PLA2G4E AGPAT6 CHKA PPAP2A PPAP2C LYPLA2 PLA2G2C AGPAT1 PLA2G2D LPCAT2 PLA2G12A AGPAT2 PLD1 CHKB PISD PLD2 PCYT1B GPAT2 LCAT CRLS1 GPD2 0.122186685
KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS ACOT4 TECR BAAT ELOVL5 ELOVL6 ACOT2 YOD1 ELOVL2 FADS1 FADS2 ACOX3 PECR SCD5 SCD PTPLA ACAA1 HADHA ACOT1 ACOT7 ACOX1 HSD17B12 PTPLB 0.155511346
KEGG_ABC_TRANSPORTERS ABCA7 ABCG4 ABCD1 ABCC12 ABCA1 TAP2 ABCA6 TAP1 ABCA5 ABCB8 ABCA10 ABCD4 ABCA3 ABCB11 ABCD3 ABCA2 ABCC2 ABCC11 ABCC6 ABCC3 ABCC9 ABCG2 ABCC4 ABCC5 ABCA12 ABCG1 ABCB4 CFTR ABCB1 ABCC1 ABCD2 ABCB6 ABCB7 ABCA8 ABCA4 ABCC8 ABCC10 ABCB10 ABCB9 ABCA13 ABCA9 ABCB5 ABCG5 ABCG8 0.208729214
KEGG_SPLICEOSOME EFTUD2 LSM5 SF3A1 HNRNPA1L2 SF3B2 PRPF19 SNRNP27 HNRNPA3 LSM6 USP39 DDX42 NCBP1 SF3B1 MAGOH CDC40 SF3B3 SRSF9 ACIN1 TXNL4A TCERG1 U2AF2 RBM17 PRPF38B THOC1 PLRG1 CCDC12 MAGOHB HSPA8 LSM7 CHERP NAA38 PQBP1 RBMX LSM4 EIF4A3 SF3A3 DDX46 RBM25 PRPF40A THOC3 NHP2L1 PRPF40B LSM2 SRSF8 SF3A2 SMNDC1 BCAS2 NCBP2 PRPF8 LOC120364 THOC4 DDX39B CWC15 DDX23 PRPF18 CDC5L SF3B5 SNRNP40 PRPF31 SNW1 DHX15 WBP11 HNRNPU CTNNBL1 HNRNPK TRA2A SNRNP200 HSPA1L HSPA1B RBM22 HSPA2 HSPA1A ZMAT2 PRPF6 DHX16 U2AF1 PRPF38A HNRNPC DDX5 DHX8 HSPA6 DHX38 ISY1 XAB2 SNRPG SNRPE SNRPF SNRPD2 SNRPD3 SART1 SYF2 CRNKL1 U2SURP HNRNPA1 PRPF3 AQR PRPF4 LSM3 SF3B4 PPIH LOC653884 SLU7 BUD31 PHF5A SRSF10 SRSF6 SNRPA RBM8A SRSF7 SNRPA1 HNRNPM SNRPB TRA2B SNRPB2 PUF60 SRSF5 SNRNP70 PCBP1 PPIL1 SF3B14 SRSF4 SRSF3 SNRPD1 THOC2 SNRPC PPIE SRSF2 SRSF1 0.125396603
KEGG_PPAR_SIGNALING_PATHWAY SLC27A5 SLC27A4 SORBS1 ACADL CYP4A11 ACADM APOA2 CD36 FADS2 APOA1 CYP7A1 SLC27A1 SCD CYP8B1 UCP1 DBI NR1H3 ACSL6 ME1 MMP1 GK GK2 APOA5 RXRB RXRG PLTP PDPK1 RXRA ILK APOC3 ACOX2 ACOX3 CYP27A1 OLR1 CPT2 ACAA1 CPT1B ANGPTL4 SLC27A2 LPL FABP1 CPT1A PCK2 FABP4 CPT1C FABP2 PCK1 SCP2 PPARA AQP7 PLIN1 CYP4A22 FABP3 FABP5 FABP6 FABP7 ACSL5 ADIPOQ SLC27A6 HMGCS2 EHHADH UBC PPARG PPARD ACSL1 SCD5 ACOX1 ACSL3 ACSL4 0.050519495
KEGG_CELL_CYCLE CDC16 CDC7 CDC45 GADD45B DBF4 ANAPC1 CREBBP MDM2 ABL1 SMC1B LOC728622 GADD45G ATM ATR ANAPC7 RBL2 ANAPC5 RBL1 MYC CDC14B SMC1A CDC14A LOC731751 SKP1 TGFB2 TGFB1 GADD45A STAG1 LOC650621 PLK1 RBX1 STAG2 TGFB3 MCM4 ORC6 CCND1 MAD1L1 MCM3 MCM6 MCM5 YWHAB CCNA2 MCM7 BUB1 CHEK1 WEE2 MCM2 PTTG1 CDC27 CDC25B CDC25C LOC651610 CDC25A CDC6 CDC20 BUB3 YWHAZ CCND2 YWHAH CCNB1 YWHAG YWHAE CCNE1 ORC3 CCND3 PTTG2 SFN E2F1 TFDP1 ZBTB17 CDK1 ESPL1 ANAPC10 RAD21 BUB1B ANAPC11 RB1 SKP2 CUL1 SMAD3 SMAD4 ANAPC2 TFDP2 PRKDC MAD2L1 ANAPC4 SMAD2 YWHAQ CHEK2 CDC23 EP300 GSK3B CDKN2A CDKN1C CDKN1B CDKN1A CDKN2D CCNA1 CDKN2B CDKN2C FZR1 SMC3 ANAPC13 PCNA TTK PKMYT1 CDK2 CDC26 E2F5 CDK4 WEE1 E2F4 E2F3 TP53 E2F2 ORC1 ORC2 CCNE2 CDK6 ORC4 CCNB2 CDK7 MAD2L2 ORC5 HDAC1 HDAC2 CCNH CCNB3 0.123307451
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS CDC16 KLHL13 PIAS3 UBA6 UBE2L6 BIRC3 HERC1 XIAP PML HERC2 PRPF19 ANAPC1 UBE2S UBE2O UBE2M UBE2Q2 MAP3K1 UBE4A BRCA1 MDM2 UBE2K UBE2D4 UBOX5 KLHL9 UBR5 UBE3A UBE2R2 RFWD2 TRIM37 FBXW8 UBE2E3 LOC652671 LOC728622 ANAPC7 ANAPC5 UBE2QL1 PIAS1 SMURF1 STUB1 UBE2G2 BTRC UBE2G1 UBE2I SOCS1 UBE2H UBE2J2 SKP1 TRAF6 FBXW11 UBE2L3 NHLRC1 UBE2N UBE4B MGRN1 LOC650621 RBX1 DDB2 NEDD4L SOCS3 SIAH1 DDB1 DET1 RNF7 BIRC2 UBE2U UBE2Z UBA7 VHL UBA1 UBE2NL PIAS4 AIRE FBXO4 CBLC UBE2A CDC27 HUWE1 UBE2B CDC34 UBE2D1 UBA3 UBE2E1 UBE2E2 UBE2D2 CDC20 UBE2D3 ITCH UBE2Q1 ANAPC10 RCHY1 UBE2W WWP1 PPIL2 TCEB1 UBE3C UBE2J1 ANAPC11 TCEB2 SAE1 UBA2 RHOBTB2 CUL5 KEAP1 SYVN1 PARK2 SKP2 PIAS2 CUL7 CUL1 FBXW7 CUL2 CUL3 UBE3B CUL4A CUL4B ANAPC2 FANCL ANAPC4 SMURF2 CDC23 CBLB CBL LOC652346 NEDD4 TRIM32 FZR1 TRIP12 UBE2F ANAPC13 FBXO2 HERC4 WWP2 UBE2C CDC26 HERC3 BIRC6 ERCC8 MID1 0.106038315
KEGG_ENDOCYTOSIS F2R EPN3 IQSEC1 IQSEC3 ADRBK2 ADRBK1 ADRB3 ADRB2 EPN2 STAMBP ADRB1 IGF1R CLTCL1 HGS VPS37C FAM125B PIP4K2B RUFY1 SMAP2 HLA-G FLT1 STAM MDM2 PIKFYVE VPS37D PIP5K1A VPS28 CHMP2B FAM125A PIP5K1B RAB11FIP1 ACAP1 ARRB2 AP2A2 GRK7 ARRB1 AP2B1 AP2A1 EEA1 GRK1 CSF1R SMURF1 LOC652799 SH3GLB1 VPS4A ARFGAP3 DNM2 HSPA8 VPS36 PARD6B RAB31 RAB11A TRAF6 CHMP4A PDCD6IP LDLR PIP5K1C NEDD4L ACAP3 CHMP5 ARAP2 IQSEC2 HLA-F MET HLA-E ARAP3 ASAP2 RAB11B RAB11FIP5 ZFYVE20 PDGFRA AGAP1 DNM3 AGAP2 ARFGAP1 ARAP1 CHMP4B CBLC ACAP2 VPS25 RAB22A EHD1 PLD1 PLD2 ITCH CDC42 SH3GLB2 PARD6A CHMP6 VTA1 RNF41 DNAJC6 ARF6 CHMP1B PSD2 USP8 PSD4 WWP1 HLA-C CXCR4 HLA-B PRKCI CXCR2 SH3GL3 CXCR1 TSG101 HLA-A ERBB4 HSPA1L HSPA1B ERBB3 HSPA2 RAB11FIP4 SH3GL1 EPS15 DNM1L HSPA1A TFRC SH3GL2 SMAP1 RAB11FIP2 FGFR2 KDR KIT FGFR4 GIT2 DNM1 FGFR3 LDLRAP1 RET CCR5 PRKCZ PSD3 ASAP3 HSPA6 RAB5C DAB2 SMURF2 HRAS CHMP3 VPS37A EGFR IL2RG VPS37B IL2RB CBLB CBL PSD NEDD4 EGF PARD6G SH3KBP1 LOC652614 ARFGAP2 RAB5B RAB4A EHD4 RAB5A AP2S1 EHD2 IL2RA EHD3 AP2M1 SNF8 SRC VPS4B STAM2 CHMP2A GIT1 GRK6 RABEP1 VPS45 RAB11FIP3 CLTA CLTB CLTC CHMP4C GRK4 PARD3 GRK5 ASAP1 NTRK1 EPN1 0.122186685
KEGG_WNT_SIGNALING_PATHWAY JUN LRP5 LRP6 PPP3R2 SFRP2 SFRP1 PPP3CC VANGL1 PPP3R1 FZD1 FZD4 APC2 FZD6 FZD7 SENP2 FZD8 LEF1 CREBBP FZD9 PRICKLE1 CTBP2 ROCK1 CTBP1 WNT9B WNT9A CTNNBIP1 DAAM2 TBL1XR1 MMP7 CER1 MAP3K7 VANGL2 WNT2B WNT11 WNT10B DKK2 LOC728622 CHP2 AXIN1 AXIN2 DKK4 NFAT5 MYC SOX17 CSNK2A1 CSNK2A2 NFATC4 CSNK1A1 NFATC3 CSNK1E BTRC PRKX SKP1 FBXW11 RBX1 CSNK2B SIAH1 TBL1Y WNT5B CCND1 CAMK2A NLK CAMK2B CAMK2D CAMK2G PRKACA APC PRKACB PRKACG WNT16 DAAM1 CHD8 FRAT1 CACYBP CCND2 NFATC2 NFATC1 CCND3 PLCB2 PLCB1 CSNK1A1L PRKCB PLCB3 PRKCA PLCB4 WIF1 PRICKLE2 PORCN RHOA FRAT2 PRKCG MAPK9 MAPK10 WNT3A DVL3 RAC2 DVL2 RAC3 FZD3 DKK1 CXXC4 DVL1 FOSL1 CUL1 WNT10A WNT4 SMAD3 TCF7 SMAD4 RAC1 TCF7L2 SMAD2 WNT1 MAPK8 EP300 WNT7A GSK3B WNT7B PSEN1 WNT8A WNT8B WNT2 WNT3 WNT5A WNT6 CTNNB1 PPP2CB PPP2CA PPP2R1A TBL1X PPP2R1B ROCK2 NKD1 FZD10 FZD5 NKD2 TCF7L1 RUVBL1 PPARD PPP3CB TP53 PPP3CA PPP2R5A PPP2R5E PPP2R5D PPP2R5C PPP2R5B FZD2 SFRP5 SFRP4 CHP 0.128403716
KEGG_DORSO_VENTRAL_AXIS_FORMATION SOS2 NOTCH4 NOTCH3 NOTCH2 EGFR NOTCH1 KRAS FMN2 LOC652554 ETV7 PIWIL3 ETV6 PIWIL2 MAP2K1 PIWIL1 GRB2 SPIRE2 CPEB1 MAPK3 ETS1 ETS2 SPIRE1 SOS1 PIWIL4 MAPK1 0.233097504
KEGG_NOTCH_SIGNALING_PATHWAY HES5 DTX3 NOTCH4 DTX3L NOTCH3 NOTCH2 EP300 HES1 NOTCH1 NUMB PSEN2 PSEN1 PTCRA SNW1 APH1A KAT2A ADAM17 RFNG RBPJ DTX1 CREBBP DTX2 MAML1 CTBP2 NCOR2 CTBP1 DVL3 JAG2 DVL2 NUMBL MAML2 KAT2B DLL4 PSENEN DLL3 DVL1 CIR1 DLL1 LFNG JAG1 MAML3 HDAC1 HDAC2 NCSTN DTX4 MFNG RBPJL 0.129292888
KEGG_ADHERENS_JUNCTION MLLT4 LOC100418883 SORBS1 WAS SNAI2 IGF1R RHOA CREBBP LEF1 ACTN4 PTPN6 ACTN1 SNAI1 ERBB2 WASF2 RAC2 PTPRJ WASL LOC646821 RAC3 PTPRF WASF1 MAP3K7 FGFR1 IQGAP1 SMAD3 MAPK3 TCF7 SMAD4 ACTG1 INSR WASF3 CTNNA1 PTPRB RAC1 TCF7L2 SMAD2 MAPK1 CSNK2A1 PVRL3 CSNK2A2 EP300 EGFR VCL CTNNA2 CTNNB1 CTNND1 FARP2 CSNK2B TGFBR2 PTPRM PVRL4 TGFBR1 ACTB TJP1 MET SSX2IP SRC NLK TCF7L1 YES1 FER BAIAP2 CTNNA3 LMO7 FYN ACP1 PTPN1 PARD3 CDC42 ACTN2 PVRL2 CDH1 ACTN3 PVRL1 0.107859121
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY CXCL10 CHUK IFNA5 IFNA4 IFNA2 POLR1D CCL5 CCL4 IFNA1 RIPK1 POLR3K AIM2 IKBKB IFNA17 CASP1 IFNA21 IFNA6 POLR3H IFNA7 IFNA8 IFNA10 IFNA13 IFNA14 IFNA16 POLR3C IKBKE POLR3G POLR3B POLR3F NFKB1 NFKBIB NFKBIA IRF3 IKBKG TREX1 POLR1C IL18 RELA ZBP1 POLR3D RIPK3 IFNB1 IL33 PYCARD POLR3GL IL1B ADAR DDX58 MAVS CCL4L1 TBK1 TMEM173 CCL4L2 POLR3A IL6 IRF7 0.249324287
KEGG_MELANOGENESIS CALM2 CALM1 TYR CREB3L1 FZD1 FZD4 FZD6 FZD7 LEF1 CREBBP CREB3 FZD8 FZD9 POMC WNT9B WNT9A CREB1 WNT2B WNT11 EDN1 WNT10B NRAS EDNRB LOC652799 KRAS PRKX GNAI1 GNAI2 CALML5 ADCY3 ADCY2 ADCY1 CREB3L3 WNT5B CAMK2A CAMK2B CAMK2D CAMK2G PRKACA GNAQ PRKACB PRKACG GNAS GNAI3 WNT16 GNAO1 CALML3 DCT CALM3 PLCB2 ADCY8 ADCY9 PLCB1 ADCY6 ADCY7 PRKCB RAF1 PLCB3 PRKCA PLCB4 ADCY5 CREB3L4 ASIP KITLG PRKCG MC1R WNT3A DVL3 DVL2 MAP2K2 MAP2K1 KIT FZD3 DVL1 ADCY4 TYRP1 WNT4 WNT10A MAPK3 TCF7 MAPK1 TCF7L2 HRAS WNT1 EP300 GSK3B WNT7A WNT7B WNT8A WNT8B WNT2 WNT3 WNT5A CTNNB1 WNT6 FZD10 CREB3L2 FZD5 TCF7L1 MITF FZD2 CALML6 0.053581282
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY STAT3 CHUK PTPN11 PPARGC1A NPY TNF SLC2A4 CD36 SLC2A1 MTOR ADIPOR2 PRKAG2 ACSL6 POMC MAPK9 MAPK10 PRKCQ RXRB RXRG IKBKB PRKAG3 RXRA TNFRSF1B ADIPOR1 AKT1 AKT2 TNFRSF1A JAK2 LEPR AKT3 CPT1B LEP ACACB NFKB1 NFKBIB NFKBIA NFKBIE IKBKG MAPK8 CPT1A PCK2 CPT1C PCK1 RELA STK11 PPARA TRAF2 PRKAB2 PRKAB1 PRKAA2 PRKAA1 SOCS3 TRADD ACSL5 ADIPOQ G6PC2 IRS2 ACSL1 AGRP PRKAG1 G6PC IRS1 CAMKK1 CAMKK2 IRS4 ACSL3 ACSL4 0.036205638
KEGG_TYPE_II_DIABETES_MELLITUS PIK3R5 GCK MAPK8 TNF MAFA SOCS1 SLC2A4 SLC2A2 MTOR SOCS2 SOCS3 INS PRKCD PRKCE MAPK9 HK2 CACNA1A MAPK10 HK3 HK1 PIK3R3 CACNA1D CACNA1E CACNA1B PDX1 CACNA1C ADIPOQ IKBKB IRS2 ABCC8 SOCS4 PIK3CA CACNA1G PIK3CB PIK3CD PRKCZ KCNJ11 MAPK3 IRS1 PKLR INSR PKM2 PIK3CG IRS4 PIK3R1 PIK3R2 MAPK1 0.072807507
KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG MNX1 NEUROG3 GCK HHEX HES1 MAFA PAX6 SLC2A2 BHLHA15 HNF1B HNF4G NKX6-1 HNF1A FOXA3 HNF4A NKX2-2 ONECUT1 NEUROD1 INS FOXA2 PAX4 PDX1 IAPP NR5A2 PKLR 0.008209418
KEGG_ALZHEIMERS_DISEASE UQCR10 NAE1 CALM2 NDUFA5 NDUFA4 COX6CP3 CALM1 ATP2A1 PPP3R2 EIF2AK3 PPP3CC ATP2A3 PPP3R1 ATP2A2 NDUFS7 CYTB ADAM17 BACE2 ATP5O COX2 COX1 COX8C MME COX3 COX5B ITPR3 PSENEN LRP1 COX4I1 APOE ATP6 ATP8 CHP2 ATP5H NDUFA2 NDUFA3 NDUFA1 CAPN2 LPL CAPN1 LOC100133737 APAF1 ATP5G1P5 HSD17B10 APH1A UQCRQ ATP5D CALML5 GAPDH ATF6 COX7A2L IDE ATP5G3 ATP5G2 ADAM10 ATP5G1 ATP5F1 ATP5E COX5A CDK5R1 ERN1 GNAQ UQCRHL ATP5A1 BACE1 CALML3 APBB1 ATP5J CYCS SDHA CALM3 NDUFA4L2 NCSTN CASP9 PLCB2 COX8A CASP8 COX7C CASP7 PLCB1 PLCB3 PLCB4 TNF LOC642502 RYR3 FADD SDHD SDHB SDHC COX7B BAD COX7A1 COX7A2 COX6C ATP5B GRIN1 GRIN2A GRIN2B COX6B1 CACNA1D BID ATP5C1 GRIN2C GRIN2D LOC644310 CACNA1C NOS1 CACNA1F CACNA1S COX7B2 CASP3 TNFRSF1A UQCRB COX6A2 MAPK3 COX6A1 UQCRH UQCRFS1 UQCRC2 UQCRC1 MAPK1 NDUFB3 NDUFB1 NDUFB2 ITPR1 NDUFA10 ITPR2 NDUFAB1 PSEN2 GSK3B PSEN1 NDUFA9 NDUFA7 NDUFA8 UQCR11 NDUFA6 NDUFV3 LOC727947 COX6B2 COX4I2 IL1B SNCA MAPT NDUFB10 NDUFS8 NDUFC1 NDUFC2 NDUFS1 NDUFV2 NDUFB6 NDUFS4 NDUFB7 NDUFV1 NDUFB8 NDUFS6 NDUFB9 NDUFS5 NDUFS2 PPP3CB NDUFB4 NDUFS3 PPP3CA APP NDUFB5 CDK5 FAS CYC1 CHP CALML6 0.189366622
KEGG_HUNTINGTONS_DISEASE POLR2G POLR2H POLR2E UQCR10 POLR2F NDUFA5 PPARGC1A NDUFA4 POLR2I COX6CP3 POLR2J TAF4 NRF1 DCTN2 CREB3L1 NDUFS7 CYTB CREBBP CREB3 POLR2K ATP5O COX2 COX1 UCP1 CLTCL1 COX8C DNALI1 POLR2L COX3 LOC729317 COX5B COX4I1 CREB1 HIP1 AP2A2 ATP6 AP2B1 DCTN4 ATP8 TAF4B ATP5H AP2A1 NDUFA2 NDUFA3 NDUFA1 DNAI1 LOC100133737 APAF1 ATP5G1P5 VDAC1 VDAC2 VDAC3 UQCRQ ATP5D DNAH1 BBC3 BDNF COX7A2L ATP5G3 ATP5G2 CREB3L3 ATP5G1 ATP5F1 ATP5E COX5A GNAQ DNAH2 SLC25A6 SP1 UQCRHL ATP5A1 SLC25A5 SLC25A4 ATP5J RCOR1 CYCS TGM2 SDHA DCTN1 POLR2B DNAL1 POLR2A NDUFA4L2 POLR2D POLR2C DNAL4 SLC25A31 CASP9 PLCB2 COX8A GRM5 CASP8 COX7C PLCB1 PLCB3 PLCB4 DNAI2 LOC642502 IFT57 CREB3L4 PPID SDHD SDHB SDHC TFAM HAP1 COX7B COX7A1 COX7A2 COX6C POLR2J2 ATP5B GRIN1 SOD1 GRIN2B COX6B1 SOD2 ATP5C1 LOC644310 BAX COX7B2 CASP3 REST UQCRB POLR2J3 COX6A2 CREB5 COX6A1 UQCRH UQCRFS1 UQCRC2 UQCRC1 SIN3A NDUFB3 NDUFB1 DLG4 TBPL2 NDUFB2 EP300 ITPR1 NDUFA10 NDUFAB1 NDUFA9 NDUFA7 NDUFA8 DNAH3 UQCR11 NDUFA6 NDUFV3 LOC727947 COX6B2 COX4I2 GPX1 TBP AP2S1 AP2M1 CREB3L2 NDUFS8 NDUFB10 NDUFC1 NDUFC2 NDUFV2 NDUFS1 NDUFS4 NDUFB6 NDUFV1 NDUFB7 NDUFS6 NDUFB8 NDUFS5 NDUFB9 PPARG NDUFS2 TP53 NDUFB4 NDUFS3 NDUFB5 CYC1 CLTA CLTB CLTC HDAC1 HDAC2 TBPL1 HTT 0.206947328
KEGG_VIBRIO_CHOLERAE_INFECTION LOC100418883 ATP6V1G1 PDIA4 ADCY9 PRKCB SLC12A2 SEC61B PRKCA TJP2 KDELR3 ATP6V0A1 ATP6V1G2 KDELR2 ATP6V0B ATP6V1G3 ATP6AP1 PRKCG CFTR LOC646821 ATP6V1F ERO1L ATP6V0A4 ATP6V0A2 ATP6V0D1 KCNQ1 ARF1 ACTG1 ATP6V0E2 SEC61G ATP6V1H PRKX ATP6V1E2 MUC2 KDELR1 ADCY3 ATP6V0D2 ATP6V0E1 ATP6V1C2 ACTB TJP1 TCIRG1 PRKACA PRKACB PRKACG GNAS ATP6V1D SEC61A2 ATP6V1A PLCG1 PLCG2 ATP6V1E1 ATP6V1B2 ATP6V1B1 SEC61A1 ATP6V1C1 ATP6V0C 0.249881724
KEGG_COLORECTAL_CANCER JUN CASP9 RAF1 BIRC5 APC2 RHOA LEF1 MSH6 BAD MAPK9 MAPK10 RAC2 RAC3 BRAF MLH1 MAP2K1 BAX AKT1 CASP3 AKT2 AKT3 AXIN1 AXIN2 SMAD3 MAPK3 SMAD4 TCF7 RAC1 MYC TCF7L2 SMAD2 MAPK1 PIK3R5 MAPK8 APPL1 GSK3B KRAS CTNNB1 TGFB2 TGFB1 ARAF TGFBR2 TGFBR1 TGFB3 CCND1 PIK3R3 BCL2 TCF7L1 MSH2 APC RALGDS TP53 MSH3 PIK3CA PIK3CB CYCS PIK3CD FOS PIK3CG DCC PIK3R1 PIK3R2 0.079263345
KEGG_PANCREATIC_CANCER CASP9 E2F1 STAT3 CHUK RAF1 ARHGEF6 STAT1 RAD51 BAD PGF MAPK9 MAPK10 ERBB2 RAC2 BRCA2 TGFA BRAF RAC3 MAP2K1 IKBKB RB1 JAK1 AKT1 AKT2 AKT3 SMAD3 MAPK3 SMAD4 NFKB1 RAC1 SMAD2 MAPK1 PIK3R5 IKBKG MAPK8 EGFR RELA KRAS CDKN2A EGF TGFB2 TGFB1 VEGFA ARAF VEGFC VEGFB TGFBR2 TGFBR1 TGFB3 CCND1 PIK3R3 RALB BCL2L1 RALA CDK4 FIGF RALBP1 RALGDS TP53 E2F3 E2F2 PIK3CA PIK3CB CDK6 PIK3CD PLD1 PIK3CG PIK3R1 CDC42 PIK3R2 0.122186685
KEGG_ENDOMETRIAL_CANCER CASP9 SOS2 RAF1 ELK1 APC2 LEF1 BAD ERBB2 MAP2K2 BRAF MLH1 MAP2K1 PDPK1 ILK AKT1 AKT2 NRAS AKT3 GRB2 AXIN1 AXIN2 MAPK3 TCF7 CTNNA1 MYC SOS1 MAPK1 TCF7L2 PIK3R5 HRAS EGFR GSK3B KRAS CTNNA2 EGF CTNNB1 ARAF CCND1 PTEN PIK3R3 TCF7L1 FOXO3 APC TP53 PIK3CA PIK3CB PIK3CD CTNNA3 PIK3CG PIK3R1 PIK3R2 CDH1 0.066019794
KEGG_PROSTATE_CANCER CASP9 SOS2 E2F1 CHUK RAF1 IGF1 CREB3L4 MTOR CREB3L1 PDGFD NKX3-1 IGF1R GSTP1 CREB3 CREBBP LEF1 BAD INS PDGFRB ERBB2 MAP2K2 TGFA BRAF MAP2K1 FGFR2 PDPK1 IKBKB MDM2 RB1 CREB1 AKT1 AKT2 FGFR1 AKT3 NRAS GRB2 CREB5 MAPK3 TCF7 NFKB1 INSRR NFKBIA SOS1 TCF7L2 MAPK1 PIK3R5 IKBKG HRAS EP300 EGFR RELA PDGFC GSK3B KRAS CDKN1B EGF CDKN1A CTNNB1 HSP90AA1 ARAF AR CREB3L3 HSP90B1 SRD5A2 CREB3L2 CCND1 PTEN PIK3R3 BCL2 PDGFA PDGFB TCF7L1 FOXO1 PDGFRA CDK2 HSP90AB1 TP53 E2F3 E2F2 PIK3CA PIK3CB CCNE2 PIK3CD KLK3 ATF4 PIK3CG CCNE1 PIK3R1 PIK3R2 0.014033193
KEGG_THYROID_CANCER PAX8 HRAS CCDC6 TFG NCOA4 KRAS CTNNB1 LEF1 CCND1 MAP2K2 TCF7L1 BRAF MAP2K1 RXRB RXRG RXRA PPARG TP53 RET NRAS TPR MAPK3 TCF7 NTRK1 MYC TPM3 CDH1 MAPK1 TCF7L2 0.005412803
KEGG_BASAL_CELL_CARCINOMA HHIP FZD1 APC2 FZD4 FZD6 PTCH2 FZD7 FZD8 LEF1 FZD9 WNT3A DVL3 WNT9B DVL2 WNT9A FZD3 DVL1 WNT2B WNT11 WNT10B SMO AXIN1 WNT4 WNT10A AXIN2 TCF7 TCF7L2 SHH WNT1 GSK3B WNT7A WNT7B WNT8A WNT8B WNT2 WNT3 WNT5A CTNNB1 WNT6 STK36 FZD10 WNT5B FZD5 GLI1 TCF7L1 BMP4 SUFU APC BMP2 GLI2 PTCH1 GLI3 WNT16 TP53 FZD2 0.072686212
KEGG_CHRONIC_MYELOID_LEUKEMIA SOS2 E2F1 CHUK PTPN11 RAF1 SHC1 BAD CTBP2 CTBP1 MAP2K2 BRAF MECOM MAP2K1 IKBKB MDM2 RB1 ABL1 AKT1 AKT2 SHC4 AKT3 NRAS GRB2 STAT5B SMAD3 MAPK3 STAT5A SMAD4 NFKB1 NFKBIA SOS1 MYC MAPK1 RUNX1 PIK3R5 IKBKG HRAS RELA GAB2 CBLB CDKN2A KRAS CBL SHC3 CDKN1B CDKN1A TGFB2 TGFB1 ARAF TGFBR2 TGFBR1 TGFB3 CCND1 PIK3R3 BCL2L1 CDK4 CBLC TP53 E2F3 E2F2 CRK PIK3CA PIK3CB CDK6 CRKL PIK3CD SHC2 HDAC1 BCR HDAC2 PIK3CG PIK3R1 PIK3R2 0.123107317
KEGG_ACUTE_MYELOID_LEUKEMIA SOS2 CHUK STAT3 ZBTB16 RAF1 RARA PML JUP MTOR CEBPA LEF1 EIF4EBP1 BAD PIM2 MAP2K2 BRAF MAP2K1 KIT FLT3 SPI1 IKBKB AKT1 AKT2 RPS6KB1 NRAS AKT3 RPS6KB2 LOC652671 GRB2 STAT5B MAPK3 TCF7 STAT5A NFKB1 MYC SOS1 TCF7L2 MAPK1 RUNX1 PIK3R5 IKBKG HRAS LOC652799 RUNX1T1 RELA KRAS LOC652346 CCNA1 ARAF CCND1 PIK3R3 TCF7L1 PPARD PIK3CA PIK3CB PIM1 PIK3CD PIK3CG PIK3R1 PIK3R2 0.014033193
KEGG_SMALL_CELL_LUNG_CANCER CASP9 MAX E2F1 CHUK LAMA1 RARB PIAS3 FN1 BIRC3 XIAP ITGA3 ITGA2B COL4A6 PTK2 COL4A1 COL4A2 PTGS2 NOS2 COL4A4 RXRB RXRG IKBKB RXRA RB1 SKP2 AKT1 AKT2 PIAS2 ITGAV LAMC2 ITGB1 AKT3 LAMB2 LAMB3 LAMC1 LAMA4 LAMA5 LAMB1 NFKB1 NFKBIA MYC PIK3R5 PIAS1 IKBKG LAMB4 RELA APAF1 CDKN1B LAMA3 LAMA2 TRAF6 TRAF5 TRAF3 CDKN2B TRAF2 FHIT TRAF1 ITGA6 CCND1 PTEN ITGA2 TRAF4 PIK3R3 BCL2 BCL2L1 BIRC2 CDK2 PIAS4 CDK4 LAMC3 TP53 E2F3 E2F2 PIK3CA PIK3CB CCNE2 CYCS CDK6 PIK3CD PIK3CG CCNE1 PIK3R1 CKS1B PIK3R2 0.009715287
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC CACNA2D1 CACNB1 LOC100418883 CACNB2 CACNB3 CACNB4 CACNG1 ITGA9 CACNG8 RYR2 JUP LMNA CACNG6 ATP2A2 CACNG7 ITGA4 ITGA3 ITGA2B ITGA7 LEF1 ITGA5 EMD ACTN4 ITGA11 DSC2 DSG2 ACTN1 DMD CACNA2D3 CACNA1D SLC8A1 LOC646821 CACNA1C CACNA1F ITGB3 CACNA2D2 CACNA1S ITGB4 ITGB5 ITGB6 ITGB7 ITGAV ITGB1 TCF7 ACTG1 CACNA2D4 PKP2 CTNNA1 CDH2 TCF7L2 ITGA10 SGCD SGCG SGCA ITGA8 SGCB CACNG2 CTNNA2 DAG1 CACNG3 CTNNB1 LAMA2 GJA1 ITGB8 ACTB ITGA6 ITGA2 ITGA1 CACNG5 CACNG4 TCF7L1 DSP DES CTNNA3 ACTN2 ACTN3 0.167592154
KEGG_VIRAL_MYOCARDITIS CASP9 LOC100418883 CASP8 HLA-DOA HLA-DOB CD80 CD86 CD28 EIF4G3 ITGAL ICAM1 CXADR MYH13 HLA-C HLA-B MYH14 HLA-DMB HLA-DMA MYH1 HLA-A DMD MYH15 RAC2 LOC646821 BID HLA-G RAC3 ABL1 ABL2 CASP3 EIF4G2 PRF1 EIF4G1 ITGB2 ACTG1 RAC1 SGCD HLA-DRB4 SGCG HLA-DRB5 SGCA SGCB HLA-DRB3 DAG1 CD55 LAMA2 LOC652614 ACTB HLA-F HLA-E CD40LG CCND1 HLA-DPA1 CD40 HLA-DPB1 MYH7B HLA-DQA1 HLA-DQA2 HLA-DQB1 CAV1 MYH3 MYH2 CYCS MYH4 MYH7 MYH6 MYH9 MYH8 MYH11 FYN MYH10 HLA-DRB1 HLA-DRA 0.197606533
BIOCARTA_RELA_PATHWAY IKBKG CHUK EP300 RELA TNF IKBKB TNFRSF1B HDAC3 TNFRSF1A TRAF6 FADD CREBBP RIPK1 NFKB1 NFKBIA TRADD 0.099699458
BIOCARTA_AKT_PATHWAY CASP9 IKBKG FOXO4 CHUK FOXO1 FOXO3 RELA PDPK1 GHR IKBKB AKT1 PIK3CA GH1 PPP2CA FASLG HSP90AA1 YWHAH BAD NFKB1 PIK3CG PIK3R1 NFKBIA 0.123307451
BIOCARTA_ALK_PATHWAY MEF2C WNT1 NPPB NPPA NOG GSK3B GATA4 CTNNB1 TGFB2 CHRD HNF1A MYL2 TGFB1 FZD1 ATF2 SMAD5 TGFBR3 TGFBR2 TGFBR1 NKX2-5 TGFB3 SMAD6 BMPR2 BMPR1A ACVR1 RFC1 BMP4 APC BMP2 MAP3K7 BMP7 DVL1 BMP5 BMP10 AXIN1 SMAD4 SMAD1 0.129292888
BIOCARTA_CD40_PATHWAY CD40LG CD40 IKBKG CHUK IKBKAP MAP3K1 RELA IKBKB DUSP1 TRAF6 TRAF3 TNFAIP3 MAP3K14 NFKB1 NFKBIA 0.059144774
BIOCARTA_CERAMIDE_PATHWAY CASP8 NSMAF BCL2 MAPK8 RAF1 MAP3K1 RELA BAX MAP2K1 TNFRSF1A MAP2K4 SMPD1 CYCS TRAF2 FADD RIPK1 MAPK3 BAD NFKB1 TRADD AIFM1 MAPK1 0.178665458
BIOCARTA_COMP_PATHWAY MASP1 C9 C2 C1S C6 C3 C5 C1QB CFD C1QA C1R C1QC MBL2 C4B C4A MASP2 C8A C7 CFB 0.128659461
BIOCARTA_CXCR4_PATHWAY HRAS PTK2 RAF1 PRKCB PRKCA RELA MAP2K1 BCAR1 GNAQ CRK GNAI1 PIK3CA CXCL12 GNGT1 GNB1 PLCG1 MAPK3 CXCR4 PTK2B PIK3C2G NFKB1 PIK3R1 PXN MAPK1 0.171783946
BIOCARTA_CELLCYCLE_PATHWAY CCND1 E2F1 TFDP1 CDK2 CDKN2A CDK4 RB1 CDKN1B CDKN1A CDK1 CDKN2D CCNA1 CDKN2B CDK6 CDKN2C CDK7 CDC25A RBL1 CCND2 CCNB1 CCNE1 CCNH CCND3 0.013419241
BIOCARTA_RNA_PATHWAY CHUK RELA MAP3K14 EIF2S2 EIF2S1 NFKB1 DNAJC3 NFKBIA EIF2AK2 TP53 0.02447038
BIOCARTA_GH_PATHWAY SRF HRAS RAF1 PRKCB PRKCA SHC1 SLC2A4 SOCS1 HNF1A INS PTPN6 MAP2K1 GHR JAK2 PIK3CA GH1 PLCG1 GRB2 MAPK3 IRS1 STAT5B STAT5A INSR PIK3CG PIK3R1 SOS1 MAPK1 RPS6KA1 0.129292888
BIOCARTA_IL5_PATHWAY CCR3 CD4 CCL11 IL4 IL1B IL5 IL5RA IL6 HLA-DRB1 HLA-DRA 0.197606533
BIOCARTA_DEATH_PATHWAY CASP10 CASP9 GAS2 CASP8 CASP7 CHUK RELA APAF1 TNFSF12 TNFSF10 BIRC3 XIAP LMNA SPTAN1 TNFRSF10A TRAF2 FADD CFLAR TNFRSF10B RIPK1 MAP3K14 TRADD TNFRSF25 BCL2 BID BIRC2 CASP6 CASP3 CYCS DFFA DFFB NFKB1 NFKBIA 0.223056414
BIOCARTA_RACCYCD_PATHWAY IKBKG HRAS E2F1 CHUK RAF1 TFDP1 RELA CDKN1B CDKN1A RHOA CCND1 CDK2 IKBKB CDK4 PAK1 RB1 AKT1 PIK3CA CDK6 MAPK3 NFKB1 CCNE1 NFKBIA PIK3R1 RAC1 MAPK1 0.055391018
BIOCARTA_MAPK_PATHWAY MEF2C JUN MEF2D MAX MEF2BNB-MEF2B CHUK RAF1 MEF2A STAT1 SHC1 ELK1 PAK2 CEBPA MKNK1 MAP2K4 RIPK1 ATF2 RAPGEF2 MAPK9 MAP3K5 MAP4K3 MAPK10 MAPK11 MAP2K2 MAP4K4 BRAF RPS6KA5 MAP2K3 MAP3K1 MAPK13 MAP3K3 MAP2K1 MAP3K4 MAP2K7 MAP3K10 MAP3K9 IKBKB MAP2K5 MAP3K11 CREB1 MAP2K6 MAP3K7 MAP3K8 MAP3K12 MAP3K6 MAP4K1 MAP4K5 RPS6KA2 RPS6KA3 DAXX RPS6KB1 RPS6KB2 GRB2 MAPK3 MAPK4 RPS6KA4 MAPK6 NFKB1 MAPK7 RAC1 NFKBIA MYC RPS6KA1 MAPK1 MAPKAPK3 HRAS MAP4K2 MAPK8 MAPKAPK5 MAPK14 MAPK12 RELA MAPKAPK2 TGFB2 MKNK2 TGFB1 TRAF2 ARAF MAP3K14 TGFBR1 TRADD TGFB3 PAK1 SP1 MAP3K13 FOS MAP3K2 0.129292888
BIOCARTA_VIP_PATHWAY EGR2 CALM2 CHUK LOC124827 RELA CALM1 PRKAR2B PPP3CC CYCSP35 LOC147908 MAP3K1 GNAQ PRKACB PRKACG PPP3CB EGR3 PPP3CA PLCG1 VIPR2 PRKAR1A PRKAR2A VIP PRKAR1B CALM3 NFATC2 NFKB1 NFATC1 NFKBIA MYC 0.099907956
BIOCARTA_NTHI_PATHWAY MAPK11 CHUK MAPK14 MAP2K3 EP300 RELA NR3C1 TNF IKBKB MAP2K6 MAP3K7 DUSP1 MYD88 CREBBP SMAD3 SMAD4 MAP3K14 TGFBR2 IL1B TLR2 NFKB1 TGFBR1 NFKBIA IL8 0.151754296
BIOCARTA_NFKB_PATHWAY IKBKG CHUK MAP3K1 RELA TNF IKBKB IL1A MAP3K7 TNFRSF1B TNFRSF1A TRAF6 MYD88 FADD TLR4 RIPK1 TNFAIP3 TAB1 MAP3K14 IL1R1 NFKB1 IRAK1 TRADD NFKBIA 0.125396603
BIOCARTA_NUCLEARRS_PATHWAY CYP2E1 ABCB4 ABCB1 RARA PPARG PPARD PPARA ABCB11 NR0B2 NR1I3 ABCC3 NR1H4 CYP1A2 NR1H3 IDDM11 0.087594285
BIOCARTA_PS1_PATHWAY WNT1 NOTCH1 GSK3B APC BTRC PSEN1 DVL1 CTNNB1 HNF1A DLL1 FZD1 ADAM17 RBPJ AXIN1 0.059144774
BIOCARTA_RAB_PATHWAY RAB27A RAB8A RAB9A RAB2A RAB6A RAB1A ACTA1 RAB4A RAB5A RAB7A RAB3A RAB11A 0.239521436
BIOCARTA_RAS_PATHWAY CASP9 HRAS FOXO4 CHUK RALA RAF1 BCL2L1 ELK1 RELA MAP2K1 RALBP1 RALGDS AKT1 PIK3CA RHOA PLD1 MAPK3 BAD NFKB1 PIK3CG RAC1 PIK3R1 CDC42 0.136926314
BIOCARTA_MAL_PATHWAY ROCK1 SRF HRAS MAP4K2 MAPK8 ACTA1 MAP2K2 RAF1 MAP3K1 MAP2K1 MAL HNF1A LIMK1 DIAPH1 RHOA MAPK3 RAC1 CDC42 MAPK1 0.123107317
BIOCARTA_IL1R_PATHWAY JUN MAPK8 CHUK MAPK14 RELA TNF TGFB2 TRAF6 MYD88 TGFB1 TOLLIP IFNB1 IFNA1 ECSIT IL1RAP MAP3K14 IRAK2 IL1B IL1R1 IRAK1 IL1RN TGFB3 MAP2K3 MAP3K1 IRAK3 IKBKB IL1A MAP2K6 MAP3K7 TAB1 NFKB1 NFKBIA IL6 0.208729214
BIOCARTA_TALL1_PATHWAY TNFRSF13C MAPK8 CHUK MAPK14 RELA TNFSF13 TNFSF13B TNFRSF13B TRAF6 TRAF5 TRAF3 TRAF2 TNFRSF17 MAP3K14 NFKB1 0.122186685
BIOCARTA_41BB_PATHWAY JUN MAP3K5 MAPK8 CHUK MAPK14 MAP3K1 RELA TNFRSF9 IKBKB MAP4K5 IFNG TRAF2 ATF2 IL4 NFKB1 NFKBIA IL2 0.037685913
BIOCARTA_STRESS_PATHWAY JUN LTA IKBKG MAP4K2 MAPK8 CHUK MAPK14 RELA TNF MAP2K4 CRADD TRAF2 TANK RIPK1 MAP3K14 TRADD MAP2K3 MAP3K1 IKBKB MAP2K6 CASP2 TNFRSF1A ATF1 NFKB1 NFKBIA 0.14308845
BIOCARTA_TNFR2_PATHWAY IKBKG LTA CHUK IKBKAP MAP3K1 RELA IKBKB TNFRSF1B DUSP1 TRAF3 TRAF2 TANK RIPK1 TNFAIP3 MAP3K14 NFKB1 TRAF1 NFKBIA 0.079179593
BIOCARTA_TOLL_PATHWAY JUN IKBKG TLR10 MAPK8 TIRAP CHUK MAPK14 ELK1 RELA TLR9 EIF2AK2 TRAF6 PPARA MAP2K4 MYD88 TOLLIP ECSIT TAB2 PGLYRP1 MAP3K14 IRAK1 TLR6 MAP2K3 MAP3K1 LY96 IKBKB MAP2K6 MAP3K7 CD14 TLR3 TLR4 TAB1 TLR7 FOS TLR2 NFKB1 NFKBIA 0.187962238
ST_WNT_CA2_CYCLIC_GMP_PATHWAY ITPR1 PDE6H CAMK2D PDE6D CAMK2G CAMK2A PDE6C CFB PDE6B TF CAMK2B NFAT5 ITPR2 PDE6A ITPKA PDE6G SLC6A13 ITPR3 DAG1 ITPKB 0.131021673
ST_TUMOR_NECROSIS_FACTOR_PATHWAY NFKBIA MAP3K7 TNFRSF1A MAP3K3 JUN TNFRSF1B NFKBIB CASP3 NR2C2 BAG4 RIPK1 CFLAR BIRC2 CASP8 NFKB2 TNF MAP2K4 BIRC3 TRAF2 TRADD IKBKG TONSL FADD NFKBIE AGFG1 TNFAIP3 NFKB1 RALBP1 NFKBIL1 0.072686212
SIG_CD40PATHWAYMAP NFKBIA MAPK14 TRAF3 MAPK3 MAPK8IP2 MAPK11 NFKBIB MAPK8IP1 PIK3R1 PIK3CD CD40 SYT1 NFKB2 TRAF6 MAP2K7 MAPKAPK5 DUSP1 MAPK13 MAP2K4 TRAF2 TRAF5 IKBKG MAPK12 TONSL MAPK8IP3 NFKBIE MAPK9 PIK3CA MAPK10 GORASP1 NFKB1 MAPK1 NFKBIL1 MAPK8 0.163727414
ST_GA12_PATHWAY PLD1 RAF1 EPHB2 VAV1 PTK2 F2RL2 MAPK7 BTK JUN PLD3 CFB F2RL3 F2 DLG4 MYEF2 PLD2 RASAL1 NR4A3 SRC MAPK1 MAP2K5 MAPK8 F2RL1 0.126803932
ST_G_ALPHA_S_PATHWAY RAF1 RAPGEF3 CAMP BRAF BFAR CREB3 CFB ASAH1 SNX13 CREB5 CREB1 MAPK1 SRC TERF2IP GAST RASGRF2 0.104918165
ST_G_ALPHA_I_PATHWAY EGFR PLCB2 SOS1 AKT1 SOS2 AKT3 ITPR2 PIK3CB TERF2IP SHC1 DRD2 STAT3 ITPKB ITPR1 RAF1 EPHB2 AKT2 KCNJ9 GRB2 PITX2 BRAF KCNJ5 CFB PLCB1 ASAH1 RGS20 PI3 ITPKA PLCB4 SRC MAPK1 KCNJ3 ITPR3 DAG1 PLCB3 0.212929509
ST_ADRENERGIC GNA15 EGFR MAPK14 AKT1 CCL13 PIK3R1 ITPR2 PIK3CD CCL15 APC ITPKB ITPR1 RAF1 GNA11 GNAQ GNAI1 KCNJ9 CAMP PITX2 BRAF KCNJ5 AR CFB PTX3 ASAH1 PIK3CA MAPK10 ITPKA SRC MAPK1 KCNJ3 GAST ITPR3 DAG1 CCL16 PHKA2 0.230442277
ST_GAQ_PATHWAY NFKBIA AKT1 VN1R1 NFKBIB AKT3 ITPR2 PIK3CB NFKB2 ITPKB ITPR1 PLD1 GNAQ PDK1 AKT2 IKBKG TONSL NFKBIE PITX2 ADRBK1 CFB PLD3 NFKB1 PLD2 ITPKA NFKBIL1 ITPR3 DAG1 PHKA2 0.02447038
ST_GA13_PATHWAY RDX NFKBIA AKT1 TBXA2R NFKBIB AKT3 PIK3CB NFKB2 PLD1 PDK1 MAP2K4 AKT2 CDC42 SRF BCL2 MAP3K1 PTK2 IKBKG SERPINA4 TONSL NFKBIE CFB PLD3 ARHGEF11 ROCK2 LPA DLG4 ROCK1 GNA13 MAP3K5 PI3 PRKD1 NFKB1 PLD2 NFKBIL1 MAPK8 PHKA2 0.014208608
ST_T_CELL_SIGNAL_TRANSDUCTION PAK4 LAT ZAP70 VAV1 NFKBIA SOS1 CTLA4 GRAP2 LCK LCP2 PRDX1 PAK3 PTPRC CSK SOS2 NFAT5 NFKBIB PAK6 NCK1 PLCG1 PAK1 ITK CD3D NFKB2 ITPKB RAF1 EPHB2 RASGRP3 CBL TONSL NFKBIE GRB2 RASGRP2 PAK7 RASGRP1 NFKB1 ITPKA PAK2 RASGRP4 MAPK1 DTYMK FBXW7 NFKBIL1 DAG1 CD28 0.082201212
ST_B_CELL_ANTIGEN_RECEPTOR CD19 PPP1R13B VAV1 NFKBIA SOS1 PRDX1 AKT1 CSK SOS2 NFKBIB NFAT5 PIK3R1 AKT3 PIK3CD MAP2K1 SHC1 BLNK NFKB2 ITPKB BCR RAF1 EPHB2 AKT2 SERPINA4 TONSL NFKBIE LYN GRB2 BTK PIK3CA PLCG2 BAD PI3 MAP2K2 NFKB1 ITPKA MAPK1 NFKBIL1 SYK DAG1 0.177870721
ST_JNK_MAPK_PATHWAY DUSP8 MAP3K10 PAPPA MAP3K7 MAP3K3 GAB1 JUN ATF2 AKT1 MAP3K13 GADD45A TAB1 NFATC3 NR2C2 MAP3K11 SHC1 TRAF6 MAP2K7 DLD MAP2K4 GCK DUSP10 DUSP4 CDC42 MAP3K1 MAPK7 MAPK9 MAP3K2 TAB2 MAP3K9 ZAK MAP3K5 MAP3K4 TP53 MAPK10 MYEF2 MAP3K12 MAP2K5 IL1R1 MAPK8 0.249324287
ST_FAS_SIGNALING_PATHWAY TUFM EZR SMPD1 MET NFKBIB CASP3 PARP1 NR0B2 PFN1 CAD MAP2K7 EPHB2 TRAF2 MAP3K1 HSPB1 MAPK8IP3 TONSL AGFG1 BAK1 ROCK1 MAP3K5 TP53 MAPK10 FAS DAXX DIABLO MAPK8 EGFR NFKBIA DEDD2 PFN2 BFAR IL1A MAPK8IP2 TPX2 FAIM2 NFAT5 MAPK8IP1 PTPN13 XIAP BAX RIPK1 CASP8 NFKB2 CASP10 CDK2AP1 MAP2K4 FAF1 ALG2 CD7 NFKBIE IL8 FADD TNFRSF6B MAPK9 BTK DEDD CSNK1A1 NFKB1 RALBP1 CASP8AP2 MAPK1 NCS1 NFKBIL1 DFFA 0.151754296
ST_MYOCYTE_AD_PATHWAY RAC1 RHO AKT1 ITPR2 APC ADRB1 ITPR1 GNAQ EPHB2 GNAI1 KCNJ9 CAMP PITX2 PLN KCNJ5 CFB KAT5 PTX3 ASAH1 CAV3 DLG4 RYR1 MAPK1 KCNJ3 GAST ITPR3 DAG1 0.167592154
SA_REG_CASCADE_OF_CYCLIN_EXPR E2F2 CDKN1B E2F1 CDK2 CCNA2 PRB1 CCNA1 CCNE1 E2F4 CCND1 CDKN2A CDK4 CCNE2 0.063443086
PID_BCR_5PATHWAY IKBKG BCL10 BLNK PTPRC HRAS PAG1 PPP3CA CD19 VAV2 NFKBIB DAPP1 RASA1 BCL2A1 PDPK1 GRB2 DOK1 CD79A PTPN6 SOS1 PTEN MAPK3 AKT1 CHUK CD72 MAPK8 PIK3CA PPP3CC MAP4K1 PIK3AP1 TRAF6 IKBKB LYN MAP3K7 CARD11 NFKB1 NFATC1 CSNK2A1 PIK3R1 PPP3CB CAMK2G INPP5D CD22 FCGR2B ETS1 SH3BP5 MAP3K1 MAPK1 MAP2K1 RELA JUN IBTK CSK NFKBIA SYK ELK1 MALT1 SHC1 PLCG2 FOS POU2F2 MAPK14 CD79B RAC1 RAF1 BTK 0.249881724
PID_LYSOPHOSPHOLIPID_PATHWAY BCAR1 PLCB3 GNAI3 GSK3B RELA PTK2 ADCY1 LYN ADCY7 PLD2 GNA12 GNAO1 HRAS ADCY4 ADCY2 NFKBIA NFKB1 ADCY8 EGFR LPAR3 LPAR1 MAGI3 LPAR4 ADRA1B GNB1 CRK PRKCD IL6 AKT1 PLCG1 TIAM1 ARHGEF1 GNA14 GNA11 LPAR2 ADCY9 RHOA MMP9 GNAZ PIK3CB MMP2 PIK3R1 GNAI1 PTK2B PRKCE PXN PRKD1 FOS IL8 GAB1 ADCY6 JUN RAC1 GNAI2 ADCY5 GNA13 GNAQ MAPT ADCY3 HBEGF CASP3 GNA15 SRC GNG2 TRIP6 SLC9A3R2 0.079263345
PID_NOTCH_PATHWAY NCOR1 NOTCH1 DTX1 FURIN SSPO DLL1 DNM1 PTCRA RAB11A NEURL CTBP1 FBXW7 NUMB CBL MFAP2 MYCBP DLL4 MAML1 SPEN MYC SKP2 CNTN6 NOTCH2 PSEN1 MAML2 YY1 GATA3 ENO1 ITCH IL4 APH1B LNX1 NCOR2 RBPJ CDKN1A JAG2 ADAM12 DLK1 EPS15 DNER SKP1 NOTCH3 RBBP8 NOTCH4 JAG1 APH1A DLL3 PSENEN MFAP5 NCSTN CCND1 EP300 HDAC1 MARK2 MIB1 ADAM10 CUL1 CNTN1 KDM1A 0.0354943
PID_P73PATHWAY TP53I3 ADA FAS PML GRAMD4 D4S234E PFDN5 WT1 EP300 PPAP2A GATA1 YAP1 BIN1 GDF15 FBXO45 RCHY1 BAX IL4R MDM2 FLOT2 PLK3 CCNB1 S100A2 AFP RNF43 MAPK11 TP73 KAT5 CDK6 SERPINE1 WWOX BRCA2 CCNA2 GNB2L1 SIRT1 PIN1 BUB3 MYC AEN CDK1 MAPK14 DEDD BBC3 CLCA2 JAG2 ABL1 PRKACB CDK2 DCP1B BCL2L11 PLK1 SFN HEY2 JAK1 RELA NDUFS2 ITCH NEDD4L PEA15 SP1 HAGH TP53AIP1 RB1 NTRK1 RAD51 TP63 FASN CHEK1 BAK1 IL1RAP HSF1 UBE4B SERPINA1 CCNE2 BUB1 FOXO3 TUBA1A CDKN1A CASP2 0.206852688
PID_WNT_NONCANONICAL_PATHWAY YES1 PRKCZ MAP3K7 TAB2 FLNA CSNK1A1 CDC42 DAAM1 FZD7 WNT5A ROR2 NFATC2 SETDB1 NLK ROCK1 RAC1 ARRB2 FZD5 MAPK8 CHD7 MAPK9 PPARG CAMK2A DVL1 RHOA FZD6 CTHRC1 DVL2 DVL3 FZD2 TAB1 MAPK10 0.079263345
PID_NFKAPPAB_ATYPICAL_PATHWAY PIK3CA NFKB1 CSNK2B SYK CSNK2A1 PIK3R1 SSPO MAPK14 LCK NFKBIA RELA SRC BCL3 IKBKB ARRB2 REL CSNK2A2 0.129292888
PID_TCR_PATHWAY SHC1 RASGRP1 AKT1 CD3D HLA-DRB1 HRAS IKBKB PRKCA CD86 RASGRP2 SH3BP2 TRAF6 IKBKG ZAP70 PTPN6 NRAS CBL ORAI1 WAS FYN PRKCB CD3E NCK1 CHUK PAG1 CSK FLNA BCL10 SLA2 HLA-DRA GAB2 PLCG1 RAP1A KRAS LCK RASSF5 LCP2 GRB2 CD80 GRAP2 MAP3K14 CD3G PTPRC LAT PRKCQ PTPN11 CD28 FYB CD4 STK39 PTEN ITK CARD11 MAP3K8 PRKCE MAP4K1 VAV1 TRPV6 CDC42 DBNL PDPK1 CD247 SOS1 INPP5D MALT1 STIM1 0.208729214
PID_NFKAPPAB_CANONICAL_PATHWAY CYLD UBE2D3 TNFAIP3 NFKBIA XPO1 MALT1 BIRC2 TRAF6 NOD2 PRKCA RELA RAN TNF IKBKG NFKB1 SSPO IKBKB RIPK2 BCL10 CHUK ATM ERC1 TNFRSF1A 0.017140543
PID_E2F_PATHWAY E2F1 RBBP4 ATM CEBPA CBX5 CREBBP YY1 MYC POLA1 E2F7 HIC1 RYBP RRM2 KAT2B UXT RB1 CDK2 WASF1 HDAC1 MCL1 CDC6 E2F5 RBL1 CES5A CDK1 PLAU EP300 KAT2A HBP1 SULT2A1 E2F2 RBL2 CES1 CCNE1 MYBL2 CES3 TOPBP1 SMARCA2 E2F3 CES4A CES2 TRIM28 CES1P1 CDC25A E2F6 CCND3 CDKN1A RANBP1 BRCA1 TP73 XRCC1 SERPINE1 RRM1 CDKN2C ORC1 CDKN1B CCNE2 TFDP2 DHFR TK1 APAF1 CCNA2 CASP7 SP1 SIRT1 TRRAP PRMT5 TFE3 CDKN2A TYMS MCM3 RBBP8 E2F4 TFDP1 0.231280201
PID_LPA4_PATHWAY LPAR4 PRKACA ADCY1 RPS6KA5 ADCY3 PRKCE ADCY8 ADCY4 CREB1 ADCY7 GNAL ADCY2 ADCY6 ADCY9 ADCY5 0.128403716
PID_AR_PATHWAY AKT1 PAWR HNRNPA1 PTK2B NCOA4 CDK6 FHL2 CTDSP1 GSN KLK3 KLK2 BRCA1 NRIP1 SVIL VAV3 CTNNB1 CASP8 CTDSP2 RANBP9 CARM1 CDK11B APPL1 HIP1 UBA3 TMPRSS2 NKX3-1 NCOA2 CDKN2A RPS6KA3 PIAS4 KDM3A PA2G4 KDM4C MED1 FKBP4 CCND1 UBE3A TMF1 PRDX1 PIAS1 XRCC6 CCND3 LATS2 UBE2I TGIF1 ZNF318 XRCC5 PELP1 CMTM2 KDM1A PRKDC SRF SNURF TGFB1I1 ZMIZ1 PATZ1 AR MAK PIAS3 NCOA6 TCF4 0.107859121
PID_NFAT_TFPATHWAY CREM CTLA4 PTGS2 PRKCQ CASP3 EGR1 IFNG FOSL1 IL8 EGR2 PPARG NFATC2 NFATC3 EGR3 TLE4 IL5 JUN GBP3 IL4 POU2F1 TBX21 CDK4 FOS CSF2 SLC3A2 IL2 NFATC1 IRF4 BATF3 FASLG TNF FOXP3 IL2RA PTPRK EGR4 DGKA JUNB E2F1 RNF128 IKZF1 IL3 PTPN1 MAF GATA3 ITCH CBLB CD40LG 0.122186685
PID_AVB3_OPN_PATHWAY VAV3 SYK PLAU MAPK8 ITGB3 MMP9 ROCK2 MAPK3 RELA PTK2B CHUK MMP2 ITGAV PIK3R1 SPP1 BCAR1 CD44 MAP3K1 NFKB1 FOS CDC42 MAP3K14 MAPK1 JUN NFKBIA RHOA RAC1 GSN PIP5K1A PIK3CA ILK 0.107859121
PID_RHOA_REG_PATHWAY SRGAP1 ARHGAP9 OPHN1 ARHGEF5 ARHGDIA FARP1 RGNEF CDKN1B NET1 MCF2 TRIO ARHGEF12 PLEKHG6 ARHGAP6 ARHGEF10L ARHGEF15 MYO9B ARHGEF10 ABR MCF2L ARHGEF3 RHOA ARHGDIG ARHGEF1 VAV1 BCR VAV2 DEF6 OBSCN AKAP13 ARAP3 ARHGEF25 DLC1 ARHGEF17 ARHGAP35 ARAP1 ARHGEF2 ARHGAP4 ARHGEF11 NGEF ARHGAP8 ARHGDIB ARHGAP5 ECT2 ARHGEF18 VAV3 0.127174075
PID_PS1_PATHWAY TLE1 DKK1 PPP2R5D APH1A JUN DLL1 KREMEN2 SSPO HNF1A AES FBXW11 DTX1 CSNK1A1 LRP6 MAP3K7 PSEN1 CTNNB1 NCSTN WNT1 NOTCH1 DKK2 NKD1 NEDD4 FRAT1 MAPK3 MYC FZD1 DVL1 AXIN1 FOS TAB1 APH1B PSENEN CSNK2A1 WIF1 PPARD ADAM10 RBPJ GSK3B CTBP1 MAPK1 CREBBP CCND1 NLK HDAC1 APC 0.129292888
PID_TRAIL_PATHWAY CFLAR PIK3R3 IKBKG MAPK1 MAP2K4 PIK3CB MAPK8 TNFRSF10A TNFRSF10D MAPK3 FADD TNFRSF10C TNFRSF10B DAP3 TNFSF10 TRADD CASP10 IKBKB RIPK1 CASP8 SMPD1 CHUK MAP3K1 PIK3R2 PIK3R1 TRAF2 PIK3CD PIK3CA 0.220269303
PID_HDAC_CLASSI_PATHWAY MBD3 CREBBP SIN3A CHD3 SMAD7 STAT3 TNFRSF1A PRKACA MXD1 SIRT2 WDR77 FKBP3 RAN SUMO1 SIRT5 YY1 NCOR2 HDAC6 MBD3L2 RANGAP1 HDAC1 RANBP2 RELA NR2C1 HDAC9 RBBP4 RBBP7 HDAC3 NCOR1 SMURF1 SMG5 KAT2B ZFPM1 HDAC10 HDAC4 MBD2 PRMT5 MTA2 NFKB1 NFKBIA TFCP2 UBE2I PPARG MAX CHD4 TNF GATAD2B SIRT3 SIRT4 HDAC2 GATA2 SAP18 HDAC11 SIN3B XPO1 SAP30 SIRT6 SIRT1 GATA1 HDAC7 SIRT7 GATAD2A SSPO EP300 HDAC8 HDAC5 0.123071103
PID_HNF3B_PATHWAY ALB PCK1 BDH1 HNF1A NF1 UCP2 NR3C1 F2 HNF4A G6PC ABCC8 SLC2A2 GCK HMGCS1 PKLR CEBPA ACADVL INS FOXA1 TTR ALDOB KCNJ11 TFRC AKT1 CEBPD CREB1 ALAS1 CEBPB HADH IGFBP1 CPT1B SP1 AFP FOXA3 HNF1B APOA1 CPT1C NKX2-1 FOXA2 CPT1A DLK1 ACADM FOXF1 TAT PDX1 0.005412803
PID_IL1_PATHWAY UBE2N MAP2K6 PIK3CA CHUK NFKB1 IKBKG TRAF6 IL1R2 MAP3K3 RELA MAP3K7 SQSTM1 PRKCI IKBKB TAB2 MYD88 PRKCZ IL1RAP UBE2V1 IRAK1 JUN IL1B MAPK8 TICAM2 ERC1 IRAK4 TAB1 PIK3R1 CASP1 IL1R1 IL1RN IL1A TOLLIP IRAK3 0.135822904
PID_TNF_PATHWAY TNF MAP4K5 SMPD1 BAG4 TRAF1 RFFL GNB2L1 NFKB1 STAT1 NSMAF MAP3K5 TRADD TAB2 IKBKB PRKCZ TNFAIP3 MAP4K4 TRAF2 RIPK1 CAV1 MAP3K3 PRKCI BIRC3 IKBKG CASP8 CHUK FADD MAP3K7 TXN SQSTM1 MAP3K1 MAP4K3 MAP4K2 SMPD2 TAB1 MAP2K3 TNIK NRK MADD MAP2K7 RELA ADAM17 TNFRSF1B CYLD TNFRSF1A BIRC2 0.212929509
PID_RXR_VDR_PATHWAY RARB NR4A1 NR1H2 VDR RXRB NR1H3 RXRG PPARG NCOA1 THRB RARA PPARD FAM120B PPARA RXRA RARG TNF RPS6KB1 TGFB1 THRA NR1H4 NCOR2 SREBF1 BCL2 ABCA1 MED1 0.123071103
PID_AP1_PATHWAY DMP1 IL4 MYC TP53 COL1A2 NPPA CCL2 FOSL1 GATA2 EGR1 CBFB NR3C1 IL5 CDKN1B HLA-A IL2 MAFG JUND PLAU TH MAF SP1 NTS GJA1 TCF7L2 MMP9 ETS1 MYB ELF1 NFATC3 CREB1 IL6 MT2A TIMP1 DUSP1 DMTF1 ATF2 FOSL2 TRIP6 ACTA1 COPS5 CDK1 CYR61 CRTC1 FABP4 BAG1 EDN1 IL10 BCL2L11 EP300 CSF2 CCND1 JUNB NFATC1 MMP1 FOSB TGFB1 IL8 ATF3 AGT HIF1A PTEN FOS CDKN2A ESR1 PENK CTNNB1 IFNG JUN NFATC2 0.005412803
PID_PDGFRB_PATHWAY SOS1 RAC1 BCAR1 ARPC4 MAPK1 HCK FOS PIK3R5 RAPGEF1 STAT5B MYOCD PAG1 WASF2 JUND ARPC3 PPP2CA FYN MAPK10 YES1 GAB1 LRP1 DOK1 NCK2 BAIAP2 SLC9A3R1 ELK1 EPS8 PRKCA PRKCD CTTN ARPC1B DOCK4 ACTN4 PDGFRB MAPK3 STAT1 VAV2 WASL KRAS LCK ACTA2 YWHAQ DNM2 ABI1 EIF2AK2 ARHGAP35 MAP2K2 ARAP1 JUN CYFIP2 PIK3CA RAB4A PTPN11 RASA1 RAF1 PIN1 PIK3CG SPHK1 ITGAV ARPC5 PTPN1 PTPN2 PLCG1 PIK3R6 FGR PIK3CB ARHGDIA YWHAH PPP2R1A PAK1 CRK BRAF MYC SFN YWHAE SHC1 SRF NCKAP1 MLLT4 PRKCE JAK2 S1PR1 NCK1 PTPRJ BRK1 ACTR3 YWHAG PTEN NRAS PPP2R2B CSK ACTR2 BLK MAPK8 RPS6KA3 TAGLN HRAS ARPC2 YWHAZ SIPA1 CBL STAT3 GRB2 ITGB3 PDGFB KSR1 PIK3R3 STAT5A MAPK9 GRB10 SLA RAP1B SLC9A3R2 MAP2K7 MAP2K4 RHOA MAP2K1 ABL1 LYN SRC RAP1A PLA2G4A YWHAB USP6NL PIK3R1 PIK3CD RAB5A IQGAP1 PIK3R2 0.212929509
PID_HIV_NEF_PATHWAY BAG4 CFLAR FAS BID CASP7 BIRC3 BCL2 MAP3K14 DAXX MAPK8 CRADD CASP3 CASP9 TNFRSF1A FADD APAF1 TRAF2 FASLG TNF CHUK RIPK1 CASP8 CD247 DFFA MAP3K5 CYCS NFKB1 TRADD RELA CASP6 DFFB CASP2 NFKBIA MAP2K7 TRAF1 0.19404442
PID_ERBB1_INTERNALIZATION_PATHWAY CHMP3 RAB5A CDC42 SHC1 ZFYVE28 SPRY2 EGF RAF1 PIK3CA NRAS AMPH PTK2 PIK3R1 UBE2D2 EGFR PIK3CB HRAS PIK3R2 EPS15 SH3KBP1 DNM1 LRIG1 SRC UBE2D3 KRAS SOS1 EPN1 SYNJ1 STAMBP HGS ARHGEF7 TSG101 SH3GL2 CBL ITSN1 PIK3R3 USP8 PIK3CD GRB2 CBLB UBE2D1 0.059144774
PID_BETA_CATENIN_NUC_PATHWAY DKK4 CTNNB1 EP300 IL8 AR SNAI2 YWHAZ KRT1 TRRAP TCF4 SALL4 SMARCA4 FGF4 TLE4 YWHAQ TBL1XR1 TCF7L1 MYF5 TCF7L2 JUN ADCY7 YWHAG INCENP DKK1 CHD8 YWHAB PITX2 CDX1 RUVBL2 AXIN2 SSPO KCNIP4 MITF ID2 YWHAE MED12 MMP9 TBL1X CTNNBIP1 SFN MDFIC CDX4 MMP2 CYR61 TERT NCOA2 COX2 ZCCHC12 CBY1 CTBP1 HBP1 NEUROG1 CUL1 SKP1 CDKN2A TNIK TCF7 AES TLE1 TLE2 HDAC2 BCL9 CCND1 MYOG VCAN LEF1 YWHAH XPO1 MYC KLF4 CDH1 DVL3 T SP5 CAMK4 HDAC1 CACNA1G APC IGF2BP1 CCND2 0.072686212
PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PTGS2 MITF KRT8 MEF2A SLC9A1 ESR1 RPS6KA4 KRT19 MAPKAPK2 ATF2 MAPK11 JUN GDI1 HSPB1 CEBPB MAPKAPK5 ATF6 MAPK14 HBP1 CSNK2B MKNK1 PLA2G4A RPS6KA5 DDIT3 NOS2 EIF4E EIF4EBP1 MAPKAPK3 ATF1 USF1 TP53 MEF2C RAB5A CSNK2A1 PPARGC1A CREB1 CSNK2A2 ELK4 0.158910202
PID_PI3KCI_AKT_PATHWAY BCL2L1 GSK3A MAPKAP1 RICTOR TBC1D4 RAF1 CASP9 HSP90AA1 MAP3K5 FOXO3 AKT3 PRKDC YWHAQ YWHAH MTOR FOXO1 YWHAG CDKN1A SFN YWHAE PDPK1 CHUK PRKACA BAD KPNA1 YWHAZ CDKN1B YWHAB AKT1 AKT2 GSK3B SRC MLST8 FOXO4 SLC2A4 0.234894946
PID_BARD1_PATHWAY NPM1 UBE2L3 TP53 CDK2 ATM FANCD2 RAD51 FANCA RBBP8 FANCE FANCL RAD50 FANCC BARD1 EWSR1 BRCA1 ATR FANCF PRKDC XRCC5 MRE11A FANCG UBE2D3 PCNA CSTF1 NBN TOPBP1 XRCC6 CCNE1 0.164096837
PID_TOLL_ENDOGENOUS_PATHWAY RHOA HMGB1 LY96 TIRAP BGN IKBKB IRAK1 IKBKG HSPD1 CHUK SFTPA1 IRAK2 VCAN TLR2 TLR1 TLR3 TLR6 CD14 TICAM1 TLR4 SAA1 S100A9 S100A8 MYD88 IRAK4 0.189650507
PID_RB_1PATHWAY PPP2CA SMARCB1 TGFB2 RBP2 CCNE1 CDKN1A RAF1 JUN BRD2 BGLAP CREBBP CBX4 CEBPA CDK4 SPI1 TBP ATF2 RUNX2 SMARCA4 MAPK14 TFDP1 DNMT1 CKM CTBP1 ATF7 E2F2 PAX3 MITF UBTF MET SUV39H1 SFTPD MAPK11 CCND3 SKP2 RBBP4 ELF1 ABL1 EP300 HDAC3 CDKN2A CCNA2 E2F3 PPARG E2F1 CCND1 CEBPD CDKN1B CDK2 MYOD1 HDAC1 TAF1 CDK6 CCND2 MAPK9 MDM2 GSC E2F4 SIRT1 AATF RB1 MEF2C PPP2R3B CEBPB CSF2 0.122186685
REACTOME_G0_AND_EARLY_G1 CDK2 LIN54 DYRK1A E2F1 E2F4 E2F5 LIN9 HDAC1 LOC441488 MYBL2 PCNA LIN37 RBBP4 RBL1 RBL2 RBBP4P1 TFDP1 CCNA2 CCNA1 CCNE1 CCNE2 LIN52 CDK1 CDC6 CDC25A 0.079263345
REACTOME_SULFUR_AMINO_ACID_METABOLISM CDO1 SLC25A10 CTH AHCY ETHE1 GCLC GCLM MAT2B GOT1 MAT1A MAT2A MTAP MTR APIP CSAD ADI1 CNDP2 SQRDL ENOPH1 BHMT SUOX TST MRI1 CBS 0.243091117
REACTOME_SIGNALING_BY_EGFR_IN_CANCER AKT3 ADAM10 SPRY1 SPRY2 STAM2 CDKN1A CDKN1B ADCY1 ADCY2 ADCY3 ADCY5 CDC37 ADCY6 ADCY7 ADCY8 CHUK ADCY9 THEM4 AP2M1 AP2S1 CLTA CLTC CREB1 CSK ADRBK1 AP2A1 AP2A2 AP2B1 EGF EGFR ADCY4 EPS15 AKT1 AKT2 FOXO1 FOXO3 PHLPP1 MTOR RICTOR GAB1 LRIG1 GRB2 GSK3A EPN1 SH3KBP1 NR4A1 HRAS HSP90AA1 ITPR2 ITPR3 KRAS MDM2 FOXO4 NRAS PDE1A PDE1B PDPK1 PIK3CA PIK3R1 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PAG1 MAPK1 MAPK3 MAP2K1 MAP2K2 BAD PTEN TRIB3 EPS15L1 RAF1 RPS6KB2 RPS27A MLST8 SH3GL2 SHC1 SOS1 SRC ADAM17 TSC2 RPS27AP11 LOC729120 LOC730418 UBA52 LOC731292 YWHAB MAPKAP1 CALM1 STAM ADAM12 CALM2 CALM3 CAMK4 CASP9 AKT1S1 CBL HGS CDK1 CDC42 0.131021673
REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING AKT3 CDKN1A CDKN1B CHUK THEM4 CREB1 NRG4 HBEGF ERBB4 EREG AKT1 AKT2 FOXO1 FOXO3 PHLPP1 MTOR RICTOR GSK3A NRG1 NR4A1 MDM2 FOXO4 PDPK1 PIK3CA PIK3R1 BAD PTEN TRIB3 RPS6KB2 MLST8 BTC TSC2 LOC729120 LOC731292 MAPKAP1 CASP9 AKT1S1 NRG2 0.248331533
REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING AKT3 CDKN1A CDKN1B CHUK THEM4 CREB1 NRG4 HBEGF EGF EGFR ERBB2 ERBB3 ERBB4 EREG AKT1 AKT2 FOXO1 FOXO3 PHLPP1 MTOR RICTOR GAB1 GRB2 GSK3A NRG1 NR4A1 MDM2 FOXO4 PDPK1 PIK3CA PIK3R1 BAD PTEN TRIB3 RPS6KB2 MLST8 BTC TSC2 LOC729120 LOC731292 MAPKAP1 CASP9 AKT1S1 NRG2 0.249324287
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION MED6 MED16 CDK8 YAP1 NCOA2 PPARGC1A GLIPR1 MED8 APOA5 PLIN2 PPARGC1B CPT1A CPT2 CREBBP CTGF CYP1A1 CYP4A11 CYP7A1 AGT ABCA1 EP300 ESRRA ALAS1 FABP1 ACSL1 MED19 FDFT1 FHL2 NCOA6 CDK19 MED13L WWTR1 TIAM2 ANKRD1 TNFRSF21 MED4 GRHL1 HMGCR HMGCS1 HMGCS2 APOA1 APOA2 ACADM SLC27A1 FADS1 MED11 ARNTL ME1 NFYA NFYB NPAS2 NRF1 G0S2 ACOX1 MED31 ANGPTL4 MED15 ABCB4 UGT1A9 PPARA PPARG MED1 MED18 MED9 MED29 TRIB3 RORA RXRA SMARCD3 SREBF1 SREBF2 SULT2A1 MED22 TBL1X TEAD1 TEAD4 TEAD3 TXNRD1 TBL1XR1 MED25 NCOA3 MED10 TEAD2 PRIC285 NCOA1 PEX11A HDAC3 CCNC MED30 MED14 MED21 MED23 MED17 MED26 MED27 MED7 MED20 CD36 NR1D1 CLOCK NCOR1 TGS1 MED24 MED12 0.128659461
REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI RIPK3 CHUK TICAM1 AGER HMGB1 APP IKBKB NFKB2 NFKBIA NFKBIB RELA S100A12 S100B SAA1 TLR3 ZBP1 IKBKG RIPK1 0.123071103
REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION MAMLD1 CREBBP E2F1 E2F3 EIF2C3 EIF2C4 EP300 SNW1 TNRC6B KAT2A EIF2C1 EIF2C2 TNRC6A RBPJ JUN MOV10 LOC441488 NOTCH2 NOTCH3 NOTCH4 MAML3 TNRC6C CCND1 TFDP1 TP53 LOC728030 MAML2 KAT2B MAML1 0.093836015
REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT COX17 SLC25A13 TIMM17B TIMM23B TIMM17A TOMM40 TIMM44 MTX2 DNAJC19 CHCHD4 GRPEL2 CS HSCB CYC1 TIMM8A LDHD PMPCA FXN SAMM50 FXC1 TIMM13 TIMM10 TIMM9 TIMM8B GFER COQ2 C18orf55 SLC25A4 SLC25A6 TIMM22 HSPA9 HSPD1 IDH3G TOMM5 LOC440490 MTX1 ATP5A1 ACO2 ATP5B PAM16 ATP5G1 TOMM7 TOMM22 BCS1L LOC642727 LOC644589 LOC646675 LOC646677 LOC650667 LOC650674 TAZ VDAC1 GRPEL1 SLC25A12 TIMM50 PMPCB TOMM20 TOMM70A 0.163727414
REACTOME_SIGNALING_BY_NOTCH4 ADAM10 JAG1 NCSTN DLL1 JAG2 NOTCH4 APH1A DLL4 PSENEN PSEN1 PSEN2 APH1B 0.133709655
REACTOME_REGULATION_OF_COMPLEMENT_CASCADE CFHR3 CR1 CD55 CFH CFI CD46 PROS1 CFB LOC653879 C2 C3 C4A C4BPA C4BPB 0.123071103
REACTOME_SIGNALING_BY_NOTCH2 ADAM10 JAG1 NCSTN DLL1 JAG2 NOTCH2 APH1A DLL4 PSENEN PSEN1 PSEN2 APH1B 0.141424029
REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING MAMLD1 ST3GAL6 TMED2 CREBBP E2F1 E2F3 EIF2C3 EIF2C4 EP300 SNW1 TNRC6B POFUT1 KAT2A EIF2C1 B4GALT1 EIF2C2 TNRC6A RBPJ JUN LFNG MFNG MOV10 LOC441488 NOTCH2 NOTCH3 NOTCH4 ATP2A1 ATP2A2 ATP2A3 FURIN MAML3 POGLUT1 TNRC6C RAB6A CCND1 RFNG SEL1L ST3GAL3 TFDP1 TP53 LOC728030 MAML2 KAT2B MAML1 0.196676524
REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI ST3GAL6 TMED2 B4GALT1 LFNG MFNG NOTCH2 NOTCH3 NOTCH4 ATP2A1 ATP2A2 ATP2A3 FURIN RAB6A RFNG SEL1L ST3GAL3 0.187163095
REACTOME_TRIGLYCERIDE_BIOSYNTHESIS AGPAT1 AGPAT2 AGPAT6 GPAT2 ACSL1 ACSL3 ACSL4 FASN GPD1L LPIN1 ACSL6 LCLAT1 LPCAT4 GK GPD1 ACACA ACLY HSD17B12 ACSL5 ELOVL2 AGPAT5 AGPAT3 AGPAT4 GPAM ELOVL5 ELOVL1 LPIN3 SLC25A1 ELOVL4 ELOVL6 LPCAT1 ELOVL7 ELOVL3 DGAT2 AGPAT9 DGAT1 TECR LPIN2 0.005412803
REACTOME_SIGNALING_BY_BMP FSTL1 SMAD1 SMAD4 SMAD5 SMAD6 SMAD7 SMURF1 GREM2 SMURF2 SKI BMP2 BMPR1A BMPR1B BMPR2 LOC731429 UBE2D1 UBE2D3 CHRDL1 ACVR2A NOG ACVR2B CER1 ZFYVE16 0.128403716
REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION CDK8 CDK9 CDKN2B E2F4 E2F5 WWTR1 HDAC1 JUNB SMAD2 SMAD3 SMAD4 SMAD7 MEN1 LOC441488 MYC SERPINE1 RBL1 TGIF2 RPS27A SP1 TFDP1 TGIF1 RPS27AP11 UBA52 CCNC CCNT1 CCNT2 0.212929509
REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN EGLN2 EGLN3 CREBBP EP300 EPAS1 EPO HIF1A ARNT EGLN1 HIF1AN RPS27A HIF3A TCEB1P3 TCEB1 TCEB2 RPS27AP11 UBA52 UBE2D1 UBE2D2 UBE2D3 VEGFA VHL CA9 CUL2 RBX1 0.162785039
REACTOME_PHOSPHOLIPID_METABOLISM COL4A3BP LPCAT3 CEPT1 CDS1 PEMT CDIPT AGPAT1 AGPAT2 SPTLC1 NEU3 CHAT PLA2G16 CHKA CHKB MGLL PLD4 DEGS2 ACER1 SLC44A3 MBOAT2 NEU4 SGPP2 AGPAT6 CSNK1G2 PIK3R6 GPAT2 PPM1L ARSK MBOAT1 PHOSPHO1 SGMS2 PIKFYVE PLD6 CERS3 SLC44A5 ARSG SACM1L GPD1L LPIN1 PIP5K1C SLC44A1 PIK3R5 PLD3 PITPNB KDSR LCLAT1 CERS6 LPCAT4 PLA2G4F GALC SUMF2 SGMS1 PLA2G2D GBA INPP5J GLA GLB1 GM2A GPD1 PLA2G4D SUMF1 CERS2 HADHA HADHB HEXA HEXB PLA2G2E PIK3R4 ENPP7 ARSI ACER2 ARSH INPPL1 ARF1 ARF3 ARSA ARSB STS ARSE ARSF ASAH1 ACHE MTM1 NEU1 NEU2 OCRL OSBP PLA2G3 PNPLA8 PCYT1A INPP5K PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PI4KA PI4KB PIP4K2A PLA2G1B PLA2G2A PLA2G4A PLA2G5 PLD1 PLD2 CRLS1 CTSA LPCAT2 ETNK2 PI4K2B AGPAT5 ACER3 PI4K2A ETNK1 SMPD3 SMPD4 VAC14 PRKD1 GPCPD1 PSAP INPP5E ASAH2 SPHK2 AGPAT3 AGPAT4 CHPT1 PNPLA2 SLC44A2 PTEN GPAM GBA2 GBA3 PCYT2 MTMR14 PLA2G2F CERK LPIN3 ASAH2C SMPD1 SMPD2 TAZ LOC729155 LOC731292 UGCG MBOAT7 CERS4 ARSJ PLBD1 LPCAT1 PNPLA3 SLC44A4 PTDSS2 SGPP1 PLA2G12A PIP5K1B PIP4K2B PLA2G6 PLA2G10 GNPAT DGAT2 AGPAT9 PIK3R3 EPT1 DEGS1 PLA2G4C PPAP2A PPAP2C PPAP2B DGAT1 CDS2 MTMR1 INPP4B SYNJ1 SYNJ2 SPHK1 SGPL1 MTMR3 MTMR2 CERS5 MTMR6 MTMR7 MTMR4 VAPB VAPA TPTE2 PCYT1B PGS1 GAL3ST1 SPTLC2 LPIN2 PTDSS1 FIG4 LPGAT1 0.113425981
REACTOME_SYNTHESIS_OF_PA AGPAT1 AGPAT2 AGPAT6 GPAT2 GPD1L LCLAT1 LPCAT4 PLA2G2D GPD1 PLA2G4D PLA2G2E PLA2G1B PLA2G2A PLA2G4A PLA2G5 PLD1 PLD2 AGPAT5 AGPAT3 AGPAT4 GPAM PLA2G2F LPCAT1 PLA2G12A PLA2G10 GNPAT AGPAT9 0.100760389
REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA EGLN2 EGLN3 EPAS1 HIF1A EGLN1 RPS27A HIF3A TCEB1P3 TCEB1 TCEB2 RPS27AP11 UBA52 UBE2D1 UBE2D2 UBE2D3 VHL CUL2 RBX1 0.129292888
REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER CDK8 CDK9 CDKN2B PARP1 E2F4 E2F5 WWTR1 HDAC1 JUNB SMAD2 SMAD3 SMAD4 SMAD7 MEN1 LOC441488 MYC SERPINE1 TRIM33 PPM1A RBL1 TGIF2 RPS27A SMURF2 SKI SKIL SP1 TFDP1 TGIF1 RPS27AP11 UBA52 UBE2D1 UBE2D3 USP9X CCNC CCNT1 CCNT2 NCOR1 NCOR2 0.059144774
REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY PARP1 HDAC1 SMAD2 SMAD3 SMAD4 TRIM33 PPM1A TGIF2 RPS27A SMURF2 SKI SKIL TGIF1 RPS27AP11 UBA52 UBE2D1 UBE2D3 USP9X NCOR1 NCOR2 0.133709655
REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM ACOT8 ABCD1 ACSL1 ACAA1 HSD17B4 FADS1 ACOX1 ELOVL2 ELOVL5 SCP2 ABCD1P5 FADS2 0.079263345
REACTOME_SYNTHESIS_OF_PC CEPT1 PEMT CHAT CHKA CHKB SLC44A3 PHOSPHO1 SLC44A5 LPIN1 SLC44A1 ACHE PCYT1A CHPT1 SLC44A2 LPIN3 SLC44A4 PCYT1B LPIN2 0.190373224
REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS LPCAT3 CEPT1 CDS1 PEMT CDIPT AGPAT1 AGPAT2 CHAT PLA2G16 CHKA CHKB MGLL PLD4 SLC44A3 MBOAT2 AGPAT6 GPAT2 MBOAT1 PHOSPHO1 PLD6 SLC44A5 GPD1L LPIN1 SLC44A1 PLD3 PITPNB LCLAT1 LPCAT4 PLA2G4F PLA2G2D GPD1 PLA2G4D HADHA HADHB PLA2G2E ACHE PLA2G3 PNPLA8 PCYT1A PLA2G1B PLA2G2A PLA2G4A PLA2G5 PLD1 PLD2 CRLS1 LPCAT2 ETNK2 AGPAT5 ETNK1 GPCPD1 AGPAT3 AGPAT4 CHPT1 PNPLA2 SLC44A2 GPAM PCYT2 PLA2G2F LPIN3 TAZ MBOAT7 PLBD1 LPCAT1 PNPLA3 SLC44A4 PTDSS2 PLA2G12A PLA2G6 PLA2G10 GNPAT DGAT2 AGPAT9 EPT1 PLA2G4C DGAT1 CDS2 PCYT1B PGS1 LPIN2 PTDSS1 LPGAT1 0.072686212
REACTOME_PI3K_AKT_ACTIVATION AKT3 CDKN1A CDKN1B CHUK THEM4 CREB1 AKT1 AKT2 FOXO1 FOXO3 PHLPP1 MTOR RICTOR GSK3A NR4A1 IRS1 RHOA MDM2 FOXO4 NGF NTRK1 PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 BAD PTEN TRIB3 RPS6KB2 MLST8 TSC2 LOC729120 LOC731292 MAPKAP1 CASP9 AKT1S1 IRS2 0.248331533
REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL AKT3 CDKN1A CDKN1B CHUK AKT1 AKT2 GSK3A MDM2 BAD TSC2 CASP9 AKT1S1 0.072807507
REACTOME_GAB1_SIGNALOSOME AKT3 CDKN1A CDKN1B CHUK THEM4 CREB1 CSK EGF EGFR AKT1 AKT2 FOXO1 FOXO3 PHLPP1 MTOR RICTOR GAB1 GRB2 GSK3A NR4A1 MDM2 FOXO4 PDPK1 PIK3CA PIK3R1 PAG1 BAD PTEN TRIB3 RPS6KB2 MLST8 SRC TSC2 LOC729120 LOC731292 MAPKAP1 CASP9 AKT1S1 0.231280201
REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS ACSL1 ACSL3 ACSL4 FASN ACSL6 ACACA ACLY HSD17B12 ACSL5 ELOVL2 ELOVL5 ELOVL1 SLC25A1 ELOVL4 ELOVL6 ELOVL7 ELOVL3 TECR 0.125597077
REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT AKT3 AKT1 AKT2 FGF10 FOXO1 NR5A2 PTF1A GCK FOXA2 FOXA3 HNF4A HNF4G ONECUT1 HES1 IAPP RBPJ INS INSM1 PDX1 MAFA ONECUT3 NEUROD1 NKX2-2 NKX6-1 NEUROG3 PAX6 PKLR SLC2A2 HNF1A HNF1B 0.009185363
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE UNC13B CHAT SLC32A1 ABAT RIMS1 GAD1 GAD2 GLS2 GLS HSPA8 MAOA SLC38A2 SLC17A7 RAB3A SLC5A7 SLC1A1 SLC1A6 SLC1A7 SLC6A1 SLC6A11 SLC6A12 SLC18A2 SLC18A3 SLC22A2 SNAP25 STX1A STXBP1 VAMP2 SYN1 SYN2 SYT1 ALDH5A1 DNAJC5 SYN3 0.165596725
REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS AKT3 AKT1 AKT2 FOXO1 GCK FOXA2 FOXA3 HNF4A HNF4G IAPP INS PDX1 MAFA NEUROD1 NKX2-2 NKX6-1 PAX6 PKLR SLC2A2 HNF1A 0.025764942
REACTOME_METABOLISM_OF_POLYAMINES ADC PAOX AMD1 GOT1 MTAP ODC1 APIP SMOX ADI1 ENOPH1 SAT1 SMS SRM AGMAT MRI1 0.129292888
REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY MAMLD1 CREBBP SNW1 KAT2A RBPJ NOTCH2 NOTCH3 NOTCH4 MAML3 LOC728030 MAML2 KAT2B MAML1 0.056151736
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM RAPGEF3 CDX2 AGPAT1 GNB5 ADCY1 ADCY2 ADCY3 RAPGEF4 ADCY5 ADCY6 ADCY7 CHRM3 ADCY8 ADCY9 GPR119 CTNNB1 ADRA2A DPP4 ADCY4 FASN PLCB1 SEC11A KCNG2 GATA4 GCG GCGR GIP GLP1R GNA11 GNA15 GNAI1 GNAI2 GNAO1 GNAQ GNAS GNB1 GNB2 GNB3 GNG3 GNG4 GNG5 GNG7 GNG10 GNG11 GNGT1 GNGT2 FFAR1 SPCS1 SLC25A4 SLC25A5 GRP SLC25A6 ACACA ACACB O3FAR1 INS ISL1 ITPR2 ITPR3 KCNB1 KCNC2 KCNJ11 KCNS3 LEP MARCKS ACLY PAX6 MLXIPL PCSK1 PRKAG2 GNG13 PFKFB1 PKLR PLCB2 PLCB3 GNG2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKAA2 PRKAB2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA GNG12 RAP1A RAP1B GNB4 SPCS3 SLC2A1 SLC2A2 LOC653566 SNAP25 STK11 STX1A STXBP1 ABCC8 VAMP2 SYT5 TALDO1 MLX TKT LOC730413 LOC730418 CACNA1A CACNB2 CACNB3 IQGAP1 SEC11C GNG8 AKAP5 GNA14 SPCS2 0.005412803
REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE RIMS1 RAB3A SLC18A2 SNAP25 STX1A STXBP1 VAMP2 SYN1 SYN2 SYT1 SYN3 0.099699458
REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION FARSB AARS DARS EPRS FARSA GARS HARS IARS KARS MARS NARS LARS PPA1 QARS RARS SARS TARS VARS WARS AIMP2 CARS YARS AIMP1 EEF1E1 0.013419241
REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY ADCY1 ADCY2 ADCY3 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCY4 GNAL 0.178665458
REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY ADCY1 ADCY2 ADCY3 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCY4 GNAI1 GNAI2 GNAI3 GNAL 0.201532244
REACTOME_DIABETES_PATHWAYS CTDSP2 PREB PDIA6 HYOU1 EXOC5 IGF2BP1 IGF2BP3 IGF2BP2 YIF1A PDIA5 KDELR3 EXOC3 EXOSC8 KLHDC3 ADD1 EXOSC6 TPP1 CPE SLC30A7 EXOC8 CTSG DCTN1 DDIT3 DDX11 DCP2 EIF2S1 ERN1 EXTL3 F2 SEC31A DIS3 ATF6 EXOSC7 EXOSC2 SEC11A GCG GH1 SERP1 SPCS1 GSK3A ERO1L HDGF CXXC1 HSPA5 IGF2 IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 KLK3 IL8 INS ACADVL KIF5B LEP LMNA DNAJB9 MMP1 MMP2 ASNS DDX12P SULT1A4 MYO5A ATF3 ATF4 NFYA NFYB PAPPA PARN EXOSC3 EXOSC1 PCSK1 PCSK2 MBTPS2 DNAJB11 GHRL PLG EXOSC9 EXOSC4 EXOC6 FKBP14 WIPI1 PPP2R5B ARFGAP1 EXOC1 EXOC2 C19orf10 DNAJC3 EXOSC5 SRPRB RAB27A BCHE EXOC4 SPCS3 PAPPA2 MBOAT4 CCL2 TSPYL2 ATF4P3 LOC644556 SHC1 SLC30A5 LOC653566 SNAP25 SRPR SSR1 STX1A SULT1A3 VAMP2 TLN1 HSP90B1 LOC730136 WFS1 XBP1 ZBTB17 PLA2G7 CALR SYVN1 KHSRP MBTPS1 SEC11C ATP6V0D1 KLF4 EIF2AK3 GOSR2 EDEM1 HERPUD1 SPCS2 TATDN2 CUL7 0.010825606
REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB ADCY1 ADCY2 ADCY3 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 CREB1 ADCY4 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B LOC730418 0.189366622
REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY NR2E3 NR1H3 NR2C2AP NR0B1 NR2F6 ESR1 ESR2 ESRRA ESRRB ESRRG NR5A2 NR5A1 NR6A1 NR3C1 NRBP1 NRBF2 NR4A1 HNF4A HNF4G AR NR3C2 NR4A2 PGR PPARA PPARD PPARG MED1 RARA RARG RORA RORB RORC RXRA RXRB RXRG NR2F1 THRA THRB NR2E1 LOC728381 LOC731106 NR1H2 VDR NR4A3 NR0B2 NR1I2 NR1D1 NR1I3 NR1D2 0.158910202
REACTOME_G1_PHASE CDK4 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CKS1B E2F1 E2F2 E2F3 E2F4 E2F5 PPP2R3B MNAT1 LOC441488 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A RB1 RBL1 RBL2 CCND1 RPS27A SKP1 SKP2 TFDP1 RPS27AP11 LOC729964 UBA52 CUL1 CCND2 CCND3 CCNH 0.034281086
REACTOME_SIGNALING_BY_PDGF AKT3 CDKN1A CDKN1B ADCY1 ADCY2 ADCY3 ADCY5 ADCY6 ADCY7 ADCY8 CHUK ADCY9 THEM4 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL5A1 COL5A2 COL6A1 COL6A2 COL6A3 COL9A1 COL9A2 COL9A3 CREB1 CRK CRKL ADRBK1 ADCY4 AKT1 AKT2 FOXO1 FOXO3 PHLPP1 MTOR RICTOR GRB2 GRB7 RAPGEF1 GSK3A NR4A1 HRAS ITPR2 ITPR3 KRAS MDM2 FOXO4 NCK1 NRAS FURIN PDE1A PDE1B PDGFA PDGFB PDGFRA PDGFRB PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLAT PLCG1 PLG PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG MAPK1 MAPK3 PDGFC MAP2K1 MAP2K2 BAD PTEN TRIB3 RAF1 RASA1 RPS6KB2 MLST8 SOS1 SPP1 SRC STAT1 STAT3 STAT5A STAT5B STAT6 THBS1 THBS2 THBS3 THBS4 TSC2 LOC729030 LOC729120 LOC730418 LOC731292 YWHAB MAPKAP1 CALM1 PDGFD CALM2 CALM3 CAMK4 CASP9 AKT1S1 NCK2 BCAR1 CDK1 0.179106867
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION AKT3 CDKN1A CDKN1B ADCY1 ADCY2 ADCY3 ADCY5 ADCY6 ADCY7 ADCY8 CHUK ADCY9 THEM4 CREB1 CRK CRKL ADRBK1 ADCY4 AKT1 AKT2 FOXO1 FOXO3 PHLPP1 MTOR RICTOR GRB2 GRB7 RAPGEF1 GSK3A NR4A1 HRAS ITPR2 ITPR3 KRAS MDM2 FOXO4 NCK1 NRAS PDE1A PDE1B PDGFA PDGFB PDGFRA PDGFRB PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG MAPK1 MAPK3 MAP2K1 MAP2K2 BAD PTEN TRIB3 RAF1 RASA1 RPS6KB2 MLST8 SOS1 SRC STAT1 STAT3 STAT5A STAT5B STAT6 TSC2 LOC729030 LOC729120 LOC730418 LOC731292 YWHAB MAPKAP1 CALM1 CALM2 CALM3 CAMK4 CASP9 AKT1S1 NCK2 BCAR1 CDK1 0.125396603
REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S CTDSP2 PREB PDIA6 HYOU1 YIF1A PDIA5 KDELR3 KLHDC3 ADD1 TPP1 DCTN1 DDX11 EXTL3 SEC31A SERP1 GSK3A HDGF CXXC1 ACADVL LMNA DNAJB9 DDX12P SULT1A4 DNAJB11 FKBP14 WIPI1 PPP2R5B ARFGAP1 C19orf10 DNAJC3 SRPRB TSPYL2 SHC1 SRPR SSR1 SULT1A3 TLN1 WFS1 XBP1 ZBTB17 SYVN1 ATP6V0D1 GOSR2 EDEM1 TATDN2 CUL7 0.008209418
REACTOME_REGULATION_OF_INSULIN_SECRETION RAPGEF3 CDX2 GNB5 RAPGEF4 ADCY5 ADCY6 CHRM3 ADCY8 GPR119 CTNNB1 ADRA2A DPP4 PLCB1 SEC11A KCNG2 GATA4 GCG GIP GLP1R GNA11 GNA15 GNAI1 GNAI2 GNAO1 GNAQ GNAS GNB1 GNB2 GNB3 GNG3 GNG4 GNG5 GNG7 GNG10 GNG11 GNGT1 GNGT2 FFAR1 SPCS1 SLC25A4 SLC25A5 GRP SLC25A6 O3FAR1 INS ISL1 ITPR2 ITPR3 KCNB1 KCNC2 KCNJ11 KCNS3 LEP MARCKS PAX6 PCSK1 GNG13 PLCB2 PLCB3 GNG2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA GNG12 RAP1A RAP1B GNB4 SPCS3 SLC2A1 SLC2A2 LOC653566 SNAP25 STX1A STXBP1 ABCC8 VAMP2 SYT5 LOC730413 LOC730418 CACNA1A CACNB2 CACNB3 IQGAP1 SEC11C GNG8 AKAP5 GNA14 SPCS2 0.008209418
REACTOME_UNFOLDED_PROTEIN_RESPONSE CTDSP2 PREB PDIA6 HYOU1 YIF1A PDIA5 KDELR3 EXOSC8 KLHDC3 ADD1 EXOSC6 TPP1 DCTN1 DDIT3 DDX11 DCP2 EIF2S1 ERN1 EXTL3 SEC31A DIS3 ATF6 EXOSC7 EXOSC2 SERP1 GSK3A HDGF CXXC1 HSPA5 IGFBP1 IL8 ACADVL LMNA DNAJB9 ASNS DDX12P SULT1A4 ATF3 ATF4 NFYA NFYB PARN EXOSC3 EXOSC1 MBTPS2 DNAJB11 EXOSC9 EXOSC4 FKBP14 WIPI1 PPP2R5B ARFGAP1 C19orf10 DNAJC3 EXOSC5 SRPRB CCL2 TSPYL2 ATF4P3 SHC1 SRPR SSR1 SULT1A3 TLN1 HSP90B1 LOC730136 WFS1 XBP1 ZBTB17 CALR SYVN1 KHSRP MBTPS1 ATP6V0D1 EIF2AK3 GOSR2 EDEM1 HERPUD1 TATDN2 CUL7 0.034147436
REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS CALCRL RAMP2 RAMP1 RAMP3 GNB5 FZD10 PTH2 ADCYAP1 ADCYAP1R1 ADM CRH CRHR2 CD55 EMR1 FZD2 GCG GCGR GHRH GHRHR GIP GIPR GLP1R GNAS GNB1 GNB2 GNB3 GNG3 GNG4 GNG5 GNG7 GNG10 GNG11 GNGT1 GNGT2 EMR2 IAPP IHH DHH WNT16 GNG13 GNG2 WNT4 GNG12 PTCH1 PTH PTHLH PTH1R PTH2R GNB4 SCT SCTR SHH LOC649279 SMO VIP VIPR1 VIPR2 WNT1 WNT2 WNT3 WNT5A WNT6 WNT7A WNT7B WNT8B WNT10B WNT11 WNT2B WNT9A WNT9B FZD5 CALCA CALCB FZD3 ADM2 WNT10A FZD1 FZD4 FZD6 FZD7 FZD8 FZD9 EMR3 PTCH2 WNT3A GLP2R GNG8 CD97 0.178665458
REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS SLC22A7 SLC2A6 SLC6A14 SLC2A13 SLC5A11 SLC22A12 SLC44A3 SLC31A1 CP SLC47A2 SLC30A7 SLC2A12 SLC2A7 SLC30A8 SLC44A5 SLC44A1 SLC16A8 SLC41A1 SLC39A6 SLC39A1 SLC39A5 SLC13A5 SLC39A3 SLC39A2 SLC2A8 SLC40A1 SLC6A19 SLC10A6 SLC6A18 SLC22A18 RHCG SLC6A20 SLC6A15 SLC47A1 SLC22A15 SLC39A4 SLC22A11 SLC2A9 SLC44A2 SLC39A10 RHAG SLC5A7 SLC39A8 SLC13A3 SLC30A5 SLC2A1 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC5A1 SLC5A2 SLC5A3 SLC6A1 SLC6A2 SLC6A3 SLC6A6 SLC6A7 SLC6A9 SLC6A11 SLC6A12 SLC11A1 SLC13A1 SLC14A1 SLC16A1 SLC18A1 SLC18A2 SLC22A1 SLC22A3 SLC22A2 SLC22A4 SLC22A5 SLC2A11 SLC30A1 SLC30A2 SLC30A3 SLC39A7 SLC44A4 SLC2A10 SLC14A2 SLC41A2 SLC22A16 SLC13A2 SLC16A3 SLC6A5 SLC16A7 SLC22A6 SLC22A8 HEPH 0.106038315
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS CALCRL RAMP2 RAMP1 RAMP3 GNB5 ADCY1 ADCY2 CGA PDE10A ADCY3 ADCY5 ADCY6 ADCY7 PTH2 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 RLN3 RXFP2 ADM TAAR1 ADORA2A ADORA2B CRH CRHR2 GPBAR1 ADRB1 ADRB2 ADRB3 DRD1 DRD5 ADCY4 FSHB FSHR GCG GCGR GHRH GHRHR GIP GIPR PDE7B GLP1R GNAI1 GNAI2 GNAI3 GNAS GNAZ GNB1 GNB2 GNB3 GNG3 GNG4 GNG5 GNG7 GNG10 GNG11 GNGT1 GNGT2 TAAR6 HRH2 HTR4 HTR6 HTR7 IAPP INSL3 NPSR1 LHB LHCGR MC1R MC2R MC3R MC4R MC5R P2RY11 PDE11A PDE1A PDE2A PDE3A PDE3B PDE4B PDE4C PDE4D PDE7A PDE8A PDE1B GNG13 GNG2 POMC AVP AVPR2 GNG12 PTGDR PTGER2 PTGER4 PTGIR PTH PTHLH PTH1R PTH2R GNB4 RXFP1 NPS RLN2 SCT SCTR TSHB TSHR LOC730002 VIP VIPR1 VIPR2 CALCA CALCB ADM2 TAAR8 PDE8B TAAR5 TAAR2 GLP2R GNG8 0.079263345
REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR ADAM10 JAG1 DLL1 JAG2 NOTCH2 NOTCH3 NOTCH4 DLL4 RPS27A ADAM17 RPS27AP11 UBA52 0.062848657
REACTOME_ZINC_TRANSPORTERS SLC30A7 SLC30A8 SLC39A6 SLC39A1 SLC39A5 SLC39A3 SLC39A2 SLC39A4 SLC39A10 SLC39A8 SLC30A5 SLC30A1 SLC30A2 SLC30A3 SLC39A7 0.005412803
REACTOME_METAL_ION_SLC_TRANSPORTERS SLC31A1 CP SLC30A7 SLC30A8 SLC41A1 SLC39A6 SLC39A1 SLC39A5 SLC39A3 SLC39A2 SLC40A1 SLC39A4 SLC39A10 SLC39A8 SLC30A5 SLC11A1 SLC30A1 SLC30A2 SLC30A3 SLC39A7 SLC41A2 HEPH 0.005412803
REACTOME_MITOTIC_G1_G1_S_PHASES CDK2 CDK4 CDK6 PSMD14 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D DBF4 CKS1B LIN54 DHFR DYRK1A E2F1 E2F2 E2F3 E2F4 E2F5 ORC6 ORC3 POLA2 FBXO5 PPP2R3B LIN9 RPA4 HDAC1 MAX MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MNAT1 LOC441488 MYBL2 MYC ORC1 ORC2 ORC4 ORC5 PCNA POLA1 POLE POLE2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A MCM10 PRIM1 PRIM2 LIN37 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMB10 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD2 PSMD3 PSMD4 PSMD5 PSMD7 PSMD8 PSMD9 PSMD10 PSMD11 PSMD12 PSMD13 PSME1 PSME2 RB1 RBBP4 RBL1 RBL2 CCND1 RPA1 RPA2 RPA3 RPS27A RRM2 RBBP4P1 DHFRP1 LOC645084 SKP1 SKP2 LOC652826 TFDP1 TK2 RPS27AP11 TYMS LOC729964 UBA52 WEE1 CDT1 CDC7 CDC45 MCM8 CUL1 CCNA2 CCNA1 CCNB1 CCND2 CCND3 CCNE1 CCNH PKMYT1 CCNE2 LIN52 PSMF1 CDK1 PSMD6 CDC6 CDC25A 0.142111339
REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX NOD1 TAB1 CHUK AGER TAB2 TAB3 HMGB1 APP IKBKB IRAK1 IRAK2 NFKB2 NFKBIA NFKBIB RELA S100A12 S100B SAA1 NOD2 MAP3K7 TRAF6 IKBKG RIPK2 0.131021673
REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS RASGRP1 RASGRP2 MGLL DGKK DGKA DGKB DGKG DGKH DGKQ DAGLB ITPR2 ITPR3 PRKCD PRKCE PRKCH PRKCQ TRPC7 TRPC3 TRPC6 LOC730221 LOC730335 DAGLA DGKE DGKD DGKI 0.183638364
REACTOME_L1CAM_INTERACTIONS RANBP9 STIP1 AP2M1 AP2S1 CLTA CLTC CNTN1 CSNK2A1 CSNK2A2 CSNK2B NCAN AP2A1 AP2A2 AP2B1 DCX DLG1 DLG3 DNM1 DNM2 DPYSL2 EGFR ALCAM FGFR1 KIF4A CNTN6 RPS6KA6 LAMA1 KIF4B ANK1 ANK3 ITGA1 ITGA2 ITGA2B ITGA5 ITGA9 ITGAV ITGB1 ITGB3 KCNQ2 KCNQ3 L1CAM LAMB1 LAMC1 MSN NCAM1 NRCAM PAK1 SPTBN5 SCN3B MAPK1 MAPK3 MAP2K1 MAP2K2 KIAA1598 SPTBN4 RAC1 RDX RPS6KA1 RPS6KA2 RPS6KA3 SCN1B SCN2A SCN2B SCN4A SCN5A SCN7A SCN8A SDCBP SH3GL2 LOC650400 SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SRC CNTN2 LOC731231 EZR CNTNAP1 NUMB NRP2 NRP1 RPS6KA4 RPS6KA5 CD24 0.157060134
REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS ANK1 ANK3 KCNQ2 KCNQ3 L1CAM NRCAM SPTBN5 SCN3B SPTBN4 SCN1B SCN2A SCN2B SCN4A SCN5A SCN7A SCN8A LOC650400 SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 LOC731231 0.206947328
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM MED6 MED16 CDK8 YAP1 NCOA2 AGPAT1 AGPAT2 PPARGC1A GLIPR1 MED8 APOA5 PLIN2 PPARGC1B CPT1A CPT1B CPT2 AGPAT6 CREBBP CTGF GPAT2 CYP1A1 CYP4A11 CYP7A1 ECI1 DECR1 AGT ECHS1 ABCA1 EP300 ESRRA ALAS1 FABP1 ACSL1 ACSL3 ACSL4 FASN MED19 FDFT1 FHL2 NCOA6 CDK19 GPD1L LPIN1 ACSL6 SIN3B MED13L LCLAT1 LPCAT4 WWTR1 SIN3A TIAM2 ANKRD1 GK TNFRSF21 GPD1 GPD2 MED4 GRHL1 HADHA HADHB HADH ACACA HMGCL HMGCR HMGCS1 HMGCS2 ACACB ACADL APOA1 APOA2 ACADM ACADS ACADVL SLC27A1 ACAT1 FADS1 MED11 ARNTL ME1 MUT ACLY NFYA NFYB NPAS2 NRF1 OXCT1 G0S2 PCCA PCCB ACOX1 MED31 ANGPTL4 HSD17B12 PRKAG2 MED15 ACSL5 ABCB4 UGT1A9 PPARA PPARG MED1 MED18 ELOVL2 MED9 AGPAT5 MED29 PRKAA2 PRKAB2 AGPAT3 AGPAT4 GPAM TRIB3 ELOVL5 RORA BDH1 RXRA ELOVL1 LPIN3 SLC25A1 SMARCD3 SREBF1 SREBF2 ELOVL4 SULT2A1 MED22 TBL1X TEAD1 TEAD4 TEAD3 TXNRD1 SLC25A20 ELOVL6 TBL1XR1 LPCAT1 ELOVL7 MED25 NCOA3 ELOVL3 MED10 TEAD2 DGAT2 MCEE AGPAT9 PRIC285 NCOA1 DGAT1 PEX11A HDAC3 CCNC MED30 MED14 MED21 MED23 MED17 MED26 MED27 MED7 MED20 CD36 TECR NR1D1 CLOCK NCOR1 NCOR2 LPIN2 TGS1 MED24 MED12 0.009472405
REACTOME_IL1_SIGNALING NOD1 TAB1 IRAK3 CHUK MAP3K8 TAB2 PELI3 TAB3 IKBKB IL1A IL1B IL1R1 IL1RAP IL1RN IRAK1 IRAK2 TMEM189-UBE2V1 MAP3K3 MYD88 IRAK4 TOLLIP MAP2K1 MAP2K6 PELI2 PELI1 NOD2 MAP2K4 SKP1 MAP3K7 TRAF6 UBE2N IL1R2 TNIP2 CUL1 IKBKG RIPK2 SQSTM1 BTRC RBX1 0.223364283
REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP GPR119 DPP4 SEC11A GATA4 GIP FFAR1 SPCS1 ISL1 PAX6 PCSK1 SPCS3 LOC653566 SEC11C SPCS2 0.171783946
REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION CDX2 GPR119 CTNNB1 DPP4 SEC11A GATA4 GCG GIP GNB3 FFAR1 SPCS1 GRP O3FAR1 ISL1 LEP PAX6 PCSK1 GNG13 SPCS3 LOC653566 SEC11C SPCS2 0.155511346
REACTOME_IRAK1_RECRUITS_IKK_COMPLEX CHUK PELI3 IKBKB IRAK1 TMEM189-UBE2V1 PELI2 PELI1 TRAF6 UBE2N IKBKG 0.122186685
REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION CHUK AGER DDX58 HMGB1 APP IKBKB MAP3K1 NFKB2 NFKBIA NFKBIB MAVS RELA S100A12 S100B SAA1 IFIH1 TRAF2 TRAF6 TRIM25 RNF135 IKBKG 0.087594285
REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION SH2B3 KIF20A CDK2 CDK5 HMG20B SH2B2 EHD1 KIF2C AKAP10 VPS45 HIST2H3C CREBBP GATA5 KLC3 ZFPM1 DOCK1 DOCK2 DOCK3 EP300 JMJD1C KIFAP3 KDM1A RCOR1 DOCK9 ZFPM2 CBX5 MAFF KIF4A ABL1 SIN3A SH2B1 KIF26A GATA1 GATA2 GATA3 GATA4 GATA6 KIF4B RACGAP1 H3F3A H3F3B HBB HBD HBE1 HBG2 HDAC1 HDAC2 EHD2 HIST2H3A IFNA1 IFNA2 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA14 IFNA16 IFNA17 IFNA21 IFNB1 H3F3AP5 IRF1 IRF2 IRF3 IRF7 ITPK1 JAK2 KIF2A KIF3C KIF5A KIF5B KLC1 KIF11 KIFC1 KIF22 MAFG LOC441511 MYB NFE2 AK3 DOCK10 PRKACA MFN1 PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B KIF15 DOCK6 RAB5A RAC1 RAD51C RAD51B ZFYVE20 KIF9 H3F3AP6 KLC2 HIST2H3D TP53 LOC730418 LOC731820 WEE1 MAFK DOCK5 AKAP1 DOCK8 CABLES2 KIF18A CAPZA1 CAPZA2 HIST1H3A HIST1H3D HIST1H3C HIST1H3E HIST1H3I HIST1H3G HIST1H3J HIST1H3H HIST1H3B KIF2B HIST1H3F KLC4 CABLES1 KIF3B KIF23 DOCK4 MFN2 CDC42 0.090113146
REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 CHUK DDX58 IKBKB MAVS IFIH1 TRIM25 CASP8 RNF135 CASP10 IKBKG RIPK1 FADD 0.123107317
REACTOME_INTERFERON_ALPHA_BETA_SIGNALING ADAR IRF9 IFITM3 IFITM2 USP18 LOC144383 EGR1 IFI6 GBP2 HLA-A HLA-B HLA-C HLA-F HLA-G IRF8 IFI27 IFI35 IFIT2 IFIT1 IFIT3 IFNA1 IFNA2 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA14 IFNA16 IFNA17 IFNA21 IFNAR1 IFNAR2 IFNB1 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 ISG20 JAK1 MX1 MX2 OAS1 OAS2 OAS3 IP6K2 XAF1 PSMB8 PTPN1 PTPN6 RNASEL HLA-K STAT1 STAT2 TYK2 IFITM1 OASL SOCS1 SOCS3 ISG15 0.242800788
REACTOME_KINESINS KIF20A KIF2C KLC3 KIFAP3 KIF4A KIF26A KIF4B RACGAP1 KIF2A KIF3C KIF5A KIF5B KLC1 KIF11 KIFC1 KIF22 KIF15 KIF9 KLC2 KIF18A KIF2B KLC4 KIF3B KIF23 0.020954109
REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING CYLD DDX58 TBK1 UBE2K IRF3 PCBP2 HERC5 PIN1 RNF125 OTUD5 MAVS RPS27A IFIH1 TNFAIP3 TRAF3 RPS27AP11 UBA52 UBA7 UBE2D1 UBE2D2 UBE2D3 TRIM25 NLRX1 NLRC5 RNF135 TAX1BP1 ATG12 UBE2L6 ATG5 ISG15 IKBKE 0.179106867
REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS TANK CHUK CREBBP CYLD AGER EP300 DDX58 DAK TBK1 UBE2K HMGB1 IFNA1 IFNA2 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA14 IFNA16 IFNA17 IFNA21 IFNB1 APP IKBKB IRF1 IRF2 IRF3 IRF7 MAP3K1 NFKB2 NFKBIA NFKBIB PCBP2 HERC5 PIN1 RNF125 OTUD5 MAVS RELA RPS27A S100A12 S100B SAA1 IFIH1 TNFAIP3 TRAF2 TRAF3 TRAF6 RPS27AP11 UBA52 UBA7 UBE2D1 UBE2D2 UBE2D3 TRIM25 DHX58 NLRX1 SIKE1 CASP8 NLRC5 RNF135 CASP10 IKBKG RIPK1 FADD TAX1BP1 ATG12 UBE2L6 ATG5 ISG15 IKBKE 0.087594285
REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 CHUK TICAM1 LY96 TICAM2 IKBKB TLR3 TLR4 IKBKG RIPK1 CD14 0.128403716
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION MED6 MED16 CDK4 CDK8 NCOA2 CEBPB CEBPD PPARGC1A MED8 CREBBP EBF1 EGR2 EP300 FABP4 MED19 NCOA6 CDK19 MED13L MED4 LEP MED11 LPL MED31 PCK1 ANGPTL4 MED15 PLIN1 PPARA PPARG MED1 MED18 MED9 MED29 RELA RXRA SLC2A4 SMARCD3 SREBF1 MED22 KLF5 TBL1X NR2F2 TGFB1 TNF WNT1 WNT10B TBL1XR1 MED25 NCOA3 MED10 PRIC285 NCOA1 HDAC3 CCNC CCND3 MED30 MED14 KLF4 ADIPOQ MED21 MED23 MED17 MED26 MED27 MED7 MED20 CD36 NCOR1 NCOR2 TGS1 MED24 MED12 0.055431112
REACTOME_SIGNALING_BY_NOTCH HDAC6 HDAC5 MAMLD1 ADAM10 CDK8 ST3GAL6 TMED2 DTX2 CNTN1 CREBBP MIB2 JAG1 DTX1 E2F1 E2F3 EIF2C3 EIF2C4 EP300 SNW1 TNRC6B DTX4 NCSTN HEY1 HEY2 POFUT1 KAT2A HEYL EIF2C1 B4GALT1 EIF2C2 TNRC6A DLL1 HDAC1 HDAC2 HIF1A HES1 RBPJ JAG2 JUN HES5 LFNG ARRB1 ARRB2 MFNG MOV10 LOC441488 MYC NOTCH2 NOTCH3 NOTCH4 ATP2A1 ATP2A2 ATP2A3 FURIN APH1A HDAC7 DLL4 FBXW7 MAML3 PSENEN HDAC8 PSEN1 PSEN2 POGLUT1 MIB1 TNRC6C RAB6A CCND1 RFNG RPS27A SEL1L ST3GAL3 SKP1 ADAM17 TBL1X TFDP1 TLE1 TLE2 TLE3 TLE4 TP53 LOC728030 RPS27AP11 UBA52 TBL1XR1 HDAC11 APH1B HDAC10 MAML2 CUL1 NUMB DLK1 HDAC3 KAT2B CCNC NEURL DNER NCOR1 NCOR2 HDAC9 HDAC4 MAML1 RBX1 0.113425981
REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS ACSL1 ACSL3 ACSL4 ACSL6 HSD17B12 ACSL5 ELOVL2 ELOVL5 ELOVL1 ELOVL4 ELOVL6 ELOVL7 ELOVL3 TECR 0.104882864
REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS MGLL FABP4 LIPE ABHD5 PLIN1 PPP1CA PPP1CB PPP1CC PRKACA PRKACB PRKACG LOC730418 CAV1 0.184973283
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX CDK8 CDK9 STUB1 CDKN2B STRAP PARP1 E2F4 E2F5 FKBP1A ARHGEF18 PPP1R15A WWTR1 HDAC1 JUNB RHOA SMAD2 SMAD3 SMAD4 SMAD7 MEN1 LOC441488 MYC FURIN SERPINE1 F11R PARD6A UCHL5 TRIM33 PPM1A PPP1CA PPP1CB PPP1CC PRKCZ PARD3 PMEPA1 SMURF1 CGN RBL1 TGIF2 RPS27A SMURF2 SKI SKIL SP1 TFDP1 TGFB1 TGFBR1 TGFBR2 TGIF1 RPS27AP11 UBA52 LOC731429 UBE2D1 UBE2D3 XPO1 USP9X CCNC CCNT1 CCNT2 MTMR4 ZFYVE9 NCOR1 NCOR2 0.072686212
REACTOME_COMPLEMENT_CASCADE MASP2 CFHR3 CR1 CRP CD55 CFD CFH CFI MBL2 CD46 PROS1 MASP1 CFB LOC651536 LOC653879 C1QA C1QB C1QC C1S C2 C3 C4A C4BPA C4BPB C5 C6 C7 C8A LOC731066 C8B C8G C9 0.146138578
REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS KCNH8 KCNV2 KCNG3 KCNH4 KCNH3 KCNG2 KCNV1 KCNH5 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNA10 KCNB1 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNH1 KCNH2 KCNQ1 KCNQ2 KCNQ3 KCNS1 KCNS2 KCNS3 KCNQ5 KCNAB1 KCNH6 KCNAB2 KCNH7 KCNQ4 KCNAB3 KCNG4 KCNB2 0.112007038
REACTOME_NOD1_2_SIGNALING_PATHWAY NOD1 TAB1 CHUK MAPK14 CYLD TAB2 TAB3 BIRC2 BIRC3 IKBKB IRAK1 IRAK2 TMEM189-UBE2V1 MAPK11 MAPK13 MAP2K6 MAPK12 NOD2 CARD9 MAP3K7 TNFAIP3 TRAF6 UBE2N CASP1 CASP2 CASP4 CASP8 CASP9 IKBKG RIPK2 0.210584571
REACTOME_PIP3_ACTIVATES_AKT_SIGNALING AKT3 CDKN1A CDKN1B CHUK THEM4 CREB1 AKT1 AKT2 FOXO1 FOXO3 PHLPP1 MTOR RICTOR GSK3A NR4A1 MDM2 FOXO4 PDPK1 BAD PTEN TRIB3 RPS6KB2 MLST8 TSC2 LOC729120 LOC731292 MAPKAP1 CASP9 AKT1S1 0.214852194
REACTOME_POTASSIUM_CHANNELS HCN4 ABCC9 KCNK7 KCNMB2 KCNH8 KCNV2 KCNG3 KCNH4 KCNH3 GABBR1 KCNG2 KCNV1 KCNMB3 KCNH5 KCNMB4 GNB1 GNB2 GNB3 GNG3 GNG4 GNG5 GNG7 GNG10 GNGT1 GNGT2 KCNK18 HCN1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNA10 KCNB1 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNH1 KCNH2 KCNJ1 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ8 KCNJ9 KCNJ10 KCNJ11 KCNJ12 KCNJ14 KCNJ15 KCNJ16 KCNK1 KCNK2 KCNK3 KCNMB1 KCNN1 KCNN2 KCNN3 KCNN4 KCNQ1 KCNQ2 KCNQ3 KCNS1 KCNS2 KCNS3 KCNK4 KCNK9 KCNK10 GNG2 GNG12 KCNQ5 KCNK13 HCN3 HCN2 ABCC8 KCNAB1 KCNH6 KCNK16 KCNAB2 KCNK17 KCNH7 KCNQ4 KCNAB3 KCNG4 KCNB2 GNG8 KCNK6 GABBR2 0.030846038
REACTOME_INWARDLY_RECTIFYING_K_CHANNELS ABCC9 GABBR1 GNB1 GNB2 GNB3 GNG3 GNG4 GNG5 GNG7 GNG10 GNGT1 GNGT2 KCNJ1 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ8 KCNJ9 KCNJ10 KCNJ11 KCNJ12 KCNJ14 KCNJ15 KCNJ16 GNG2 GNG12 ABCC8 GNG8 GABBR2 0.055391018
REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT MASP2 CRP CFD MBL2 MASP1 CFB LOC651536 LOC653879 C1QA C1QB C1QC C1S C2 C3 C4A LOC731066 0.122186685