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Right now when calculating influence, the diffnetwork.txt file that is created displays the most important TF-target gene differences, and I think what is the Interaction score (P)?
Right now I'm noticing that for a lot of TFs of interest, the top target genes are shared. I guess this is due to the distance from TF in the GRN only having a modest impact on the interaction score. (E.g. PAX6 targets PITX, therefore PITX targets are also PAX6 target genes)
Would it be possible to also include some of the other values that go into the influence score like (L) distance from TF in the GRN?
And potentially even the TF node upstream of the distance? But I can imagine that that might not be calculated automatically. But the distance of the target gene to the TF should be doable to include in the output right?
e.g.:
I think this could drastically help with the interpretation of some of the interactions. If needed I can try to take a look in the python code to see if i can implement it, but that would probably also take some time. :)
Gr Jos
The text was updated successfully, but these errors were encountered:
I think I figured out where to add stuff in the code to get more in the output files. Ill work on it, try to test it out and see if i can add this kind of functionality somewhere today or tomorrow.
If succesfull I'll make a pull request. If unsuccesfull Ill be sad and might bother somebody with additional questions.
Right now when calculating influence, the diffnetwork.txt file that is created displays the most important TF-target gene differences, and I think what is the Interaction score (P)?
Right now I'm noticing that for a lot of TFs of interest, the top target genes are shared. I guess this is due to the distance from TF in the GRN only having a modest impact on the interaction score. (E.g. PAX6 targets PITX, therefore PITX targets are also PAX6 target genes)
Would it be possible to also include some of the other values that go into the influence score like (L) distance from TF in the GRN?
And potentially even the TF node upstream of the distance? But I can imagine that that might not be calculated automatically. But the distance of the target gene to the TF should be doable to include in the output right?
e.g.:
I think this could drastically help with the interpretation of some of the interactions. If needed I can try to take a look in the python code to see if i can implement it, but that would probably also take some time. :)
Gr Jos
The text was updated successfully, but these errors were encountered: