diff --git a/pathways/WP179/WP179.gpml b/pathways/WP179/WP179.gpml index cfa4b9a13..8484fcc3c 100644 --- a/pathways/WP179/WP179.gpml +++ b/pathways/WP179/WP179.gpml @@ -1,5 +1,5 @@ - + The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle. Sources: [http://en.wikipedia.org/wiki/Cell_cycle Wikipedia:Cell cycle], [http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html KEGG]. Protein phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org. @@ -1004,6 +1004,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + parentid=P84022; parentsymbol=SMAD3; site=PQSNIPEtPPPGYLS; position=thr179; sitegrpid=451177; ptm=p; direction=u + + + + + parentid=Q15796; parentsymbol=SMAD2; site=QSNYIPEtPPPGYIS; position=thr220; sitegrpid=448793; ptm=p; direction=u + + + parentid=P30281; parentsymbol=CCND3; site=QGPsQtstPtDVtAI; position=thr283; sitegrpid=452160; ptm=p; direction=d @@ -1025,6 +1035,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. + parentid=P46527; parentsymbol=CDKN1B; site=NAGsVEQtPKKPGLR; position=thr187; sitegrpid=447875; ptm=p; direction=d @@ -1722,19 +1733,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - 25514926 - PubMed - PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. - Nucleic Acids Res - 2015 - Hornbeck PV - Zhang B - Murray B - Kornhauser JM - Latham V - Skrzypek E - + + cell cycle pathway, mitotic + PW:0000086 + Pathway Ontology + 9733515 PubMed @@ -1751,11 +1754,19 @@ Proteins on this pathway have targeted assays available via the [https://assays. Kastan MB Siliciano JD - - cell cycle pathway, mitotic - PW:0000086 - Pathway Ontology - + + 25514926 + PubMed + PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. + Nucleic Acids Res + 2015 + Hornbeck PV + Zhang B + Murray B + Kornhauser JM + Latham V + Skrzypek E + diff --git a/pathways/WP179/WP179.json b/pathways/WP179/WP179.json index 8b73ce9b8..32f7a9f8b 100644 --- a/pathways/WP179/WP179.json +++ b/pathways/WP179/WP179.json @@ -1231,6 +1231,43 @@ "y": 229.09173478655768, "zIndex": 28688 }, + "a68ca": { + "attachmentDisplay": { + "offset": [ + 0, + 0 + ], + "position": [ + 1, + 0.08695652173913043 + ] + }, + "comments": [ + { + "content": "parentid=Q15796; parentsymbol=SMAD2; site=QSNYIPEtPPPGYIS; position=thr220; sitegrpid=448793; ptm=p; direction=u" + } + ], + "drawAs": "Ellipse", + "fill": "#ffffff", + "fontSize": 10, + "gpmlElementName": "State", + "height": 15, + "id": "a68ca", + "isAttachedTo": "ea6ed", + "kaavioType": "Burr", + "padding": 1, + "stateType": "Unknown", + "stroke": "#000000", + "strokeWidth": 1, + "textAlign": "center", + "textContent": "P", + "type": [ + "State", + "Burr" + ], + "verticalAlign": "middle", + "width": 15 + }, "a73": { "backpageHead": "CCNA2 | cyclin A2", "comments": [ @@ -7302,6 +7339,9 @@ }, "cb2": { "backpageHead": "SMAD3 | SMAD mothers against DPP homolog 3 (Dr...", + "burrs": [ + "f2061" + ], "comments": [ { "content": "MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)", @@ -8325,6 +8365,11 @@ 0.13043478260869318 ] }, + "comments": [ + { + "content": "parentid=P46527; parentsymbol=CDKN1B; site=NAGsVEQtPKKPGLR; position=thr187; sitegrpid=447875; ptm=p; direction=d" + } + ], "drawAs": "Ellipse", "fill": "#ffffff", "fontSize": 10, @@ -12148,6 +12193,9 @@ }, "ea6ed": { "backpageHead": "SMAD3 | SMAD mothers against DPP homolog 3 (Dr...", + "burrs": [ + "a68ca" + ], "comments": [ { "content": "MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)", @@ -13315,6 +13363,43 @@ "y": 81.00000000000034, "zIndex": 32910 }, + "f2061": { + "attachmentDisplay": { + "offset": [ + 0, + 0 + ], + "position": [ + 1, + 0.2173913043478261 + ] + }, + "comments": [ + { + "content": "parentid=P84022; parentsymbol=SMAD3; site=PQSNIPEtPPPGYLS; position=thr179; sitegrpid=451177; ptm=p; direction=u" + } + ], + "drawAs": "Ellipse", + "fill": "#ffffff", + "fontSize": 10, + "gpmlElementName": "State", + "height": 15, + "id": "f2061", + "isAttachedTo": "cb2", + "kaavioType": "Burr", + "padding": 1, + "stateType": "Unknown", + "stroke": "#000000", + "strokeWidth": 1, + "textAlign": "center", + "textContent": "P", + "type": [ + "State", + "Burr" + ], + "verticalAlign": "middle", + "width": 15 + }, "f26": { "drawAs": "none", "fill": "transparent", @@ -16273,7 +16358,7 @@ "d5024", "pvjsgeneratedidff177" ], - "dataSourceVersion": "WP179_r127255", + "dataSourceVersion": "WP179_r127262", "displayName": "Cell cycle", "drawAs": "rect", "fill": "white", @@ -16283,7 +16368,7 @@ "height": 1014.5595238095249, "id": "WP179", "kaavioType": "Group", - "lastModified": "20230828181637", + "lastModified": "20230830045222", "name": "Cell cycle", "organism": "Homo sapiens", "padding": 5, @@ -16292,7 +16377,7 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Cell cycle\nLast Modified: 20230828181637\nOrganism: Homo sapiens", + "textContent": "Name: Cell cycle\nLast Modified: 20230830045222\nOrganism: Homo sapiens", "type": [ "Pathway", "http://identifiers.org/pw/PW:0000086" diff --git a/pathways/WP179/WP179.png b/pathways/WP179/WP179.png index d7cc3fa26..450559707 100644 Binary files a/pathways/WP179/WP179.png and b/pathways/WP179/WP179.png differ diff --git a/pathways/WP179/WP179.svg b/pathways/WP179/WP179.svg index 4e5dd964e..df8f8553a 100644 --- a/pathways/WP179/WP179.svg +++ b/pathways/WP179/WP179.svg @@ -448,7 +448,7 @@ - + @@ -1508,12 +1508,24 @@ + + + + P + + SMAD3 + + + + P + + SMAD2 @@ -2267,7 +2279,7 @@ Name: Cell cycle - Last Modified: 20230828181637 + Last Modified: 20230830045222 Organism: Homo sapiens