diff --git a/pathways/WP112/WP112-datanodes.tsv b/pathways/WP112/WP112-datanodes.tsv index 0afe88a84..0da9fefe9 100644 --- a/pathways/WP112/WP112-datanodes.tsv +++ b/pathways/WP112/WP112-datanodes.tsv @@ -1,128 +1,116 @@ -Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI -2-Phosphoglycerate Metabolite cas:2553-59-5 wikidata:Q209469 chebi:24344;chebi:24344 inchikey:GXIURPTVHJPJLF-UHFFFAOYSA-N -Fructose 1,6-bisphosphate Metabolite cas:488-69-7 wikidata:Q414945;wikidata:Q28529691 chebi:28013;chebi:16905;chebi:28013;chebi:16905;chebi:37736 inchikey:RNBGYGVWRKECFJ-ARQDHWQXSA-N;inchikey:XPYBSIWDXQFNMH-UYFOZJQFSA-N -Glucose-6-phosphate Metabolite cas:59-56-3 wikidata:Q418865 chebi:29042;chebi:29042 inchikey:HXXFSFRBOHSIMQ-VFUOTHLCSA-N -Glyceraldehyde-3-phosphate Metabolite chebi:17138 wikidata:Q794810 chebi:17138;chebi:17138 inchikey:LXJXRIRHZLFYRP-UHFFFAOYSA-N -D-6-Phospho-glucono-delta-lactone Metabolite cas:90-80-2 wikidata:Q114174 chebi:16217;chebi:16217 inchikey:PHOQVHQSTUBQQK-SQOUGZDYSA-N -Acetate Metabolite cas:64-19-7 wikidata:Q47512 chebi:15366;chebi:15366 inchikey:QTBSBXVTEAMEQO-UHFFFAOYSA-N -Oxaloacetate Metabolite cas:328-42-7 wikidata:Q408658 chebi:30744;chebi:30744 inchikey:KHPXUQMNIQBQEV-UHFFFAOYSA-N -Glucose Metabolite wikidata:Q37525 wikidata:Q37525 chebi:17234;chebi:17234 -Phosphoenolpyruvate Metabolite cas:138-08-9 wikidata:Q412139 chebi:44897;chebi:44897 inchikey:DTBNBXWJWCWCIK-UHFFFAOYSA-N -Acetaldehyde Metabolite cas:75-07-0 wikidata:Q61457 chebi:15343;chebi:15343 inchikey:IKHGUXGNUITLKF-UHFFFAOYSA-N;inchikey:WGYWEDJQQFKGID-ZTKYFMRJSA-O;inchikey:MBSKDCPWFSMEFD-ZKVZURMCSA-O -Ethanol Metabolite cas:64-17-5 wikidata:Q153 chebi:16236;chebi:16236 inchikey:LFQSCWFLJHTTHZ-UHFFFAOYSA-N -Glycerol 3-phosphate Metabolite cas:57-03-4 wikidata:Q2739882 chebi:15978;chebi:14336;chebi:14336;chebi:15978 inchikey:AWUCVROLDVIAJX-UHFFFAOYSA-N;inchikey:AWUCVROLDVIAJX-GSVOUGTGSA-N -Acetyl-CoA Metabolite cas:72-89-9 wikidata:Q715317 chebi:15351;chebi:15351 inchikey:ZSLZBFCDCINBPY-ZSJPKINUSA-N -Phosphate Metabolite cas:14265-44-2 wikidata:Q177811 chebi:26078;chebi:18367;chebi:26078;chebi:18367 inchikey:NBIIXXVUZAFLBC-UHFFFAOYSA-K;inchikey:NBIIXXVUZAFLBC-UHFFFAOYSA-N -3-Phosphoglycerate Metabolite cas:820-11-1 wikidata:Q32904835 chebi:17050;chebi:17050 inchikey:OSJPPGNTCRNQQC-UHFFFAOYSA-N -D-Ribose-5-Phosphate Metabolite cas:3615-55-2 wikidata:Q27125661 chebi:58273;chebi:58273 inchikey:PPQRONHOSHZGFQ-LMVFSUKVSA-L -Fructose-6-phosphate Metabolite cas:643-13-0 wikidata:Q32039197 chebi:61553;chebi:15946;chebi:15946 inchikey:GSXOAOHZAIYLCY-HSUXUTPPSA-N -6-Phosphogluconate Metabolite cas:921-62-0 wikidata:Q245501 chebi:48928;chebi:48928 inchikey:BIRSGZKFKXLSJQ-SQOUGZDYSA-N -Glycerol Metabolite cas:56-81-5 wikidata:Q132501 chebi:17754;chebi:17754 inchikey:PEDCQBHIVMGVHV-UHFFFAOYSA-N -Dihydroxyacetone Metabolite cas:96-26-4 wikidata:Q409618 chebi:16016;chebi:16016 inchikey:RXKJFZQQPQGTFL-UHFFFAOYSA-N -Erythrose-4-phosphate Metabolite cas:585-18-2 wikidata:Q32039231 chebi:48153;chebi:48153 inchikey:NGHMDNPXVRFFGS-IUYQGCFVSA-N -Ribulose-5-phosphate Metabolite cas:4151-19-3 wikidata:Q418886 chebi:37455;chebi:17363;chebi:17363;chebi:37455;chebi:17666;chebi:17797 inchikey:FNZLKVNUWIIPSJ-UHNVWZDZSA-N -Malate Metabolite cas:6915-15-7 wikidata:Q190143 chebi:6650;chebi:6650 inchikey:BJEPYKJPYRNKOW-UHFFFAOYSA-N -Ethanol Metabolite cas:64-17-5 wikidata:Q153 chebi:16236;chebi:16236 inchikey:LFQSCWFLJHTTHZ-UHFFFAOYSA-N -Glyceraldehyde-3-phosphate Metabolite chebi:17138 wikidata:Q794810 chebi:17138;chebi:17138 inchikey:LXJXRIRHZLFYRP-UHFFFAOYSA-N -Pyruvate Metabolite cas:127-17-3 wikidata:Q213580 chebi:32816;chebi:32816 inchikey:LCTONWCANYUPML-UHFFFAOYSA-N -Sedoheptulose-7-phosphate Metabolite cas:2646-35-7 wikidata:Q3040325 chebi:15721;chebi:15721 inchikey:JDTUMPKOJBQPKX-GBNDHIKLSA-N -1,3-Bisphosphoglycerate Metabolite cas:1981-49-3 wikidata:Q1020557 chebi:89363;chebi:89363 inchikey:LJQLQCAXBUHEAZ-UHFFFAOYSA-N -Xylulose-5-phosphate Metabolite cas:60802-29-1 wikidata:Q37864045 chebi:27354;chebi:27354 inchikey:FNZLKVNUWIIPSJ-UHFFFAOYSA-N -Acetate Metabolite cas:64-19-7 wikidata:Q47512 chebi:15366;chebi:15366 inchikey:QTBSBXVTEAMEQO-UHFFFAOYSA-N -Fructose-6-phosphate Metabolite cas:643-13-0 wikidata:Q32039197 chebi:61553;chebi:15946;chebi:15946 inchikey:GSXOAOHZAIYLCY-HSUXUTPPSA-N -Xylulose-5-phosphate Metabolite cas:60802-29-1 wikidata:Q37864045 chebi:27354;chebi:27354 inchikey:FNZLKVNUWIIPSJ-UHFFFAOYSA-N -Acetaldehyde Metabolite cas:75-07-0 wikidata:Q61457 chebi:15343;chebi:15343 inchikey:IKHGUXGNUITLKF-UHFFFAOYSA-N;inchikey:WGYWEDJQQFKGID-ZTKYFMRJSA-O;inchikey:MBSKDCPWFSMEFD-ZKVZURMCSA-O -Isocitrate Metabolite cas:320-77-4 wikidata:Q288927 chebi:30887;chebi:30887 inchikey:ODBLHEXUDAPZAU-UHFFFAOYSA-N -Fumarate Metabolite hmdb:HMDB0000134 chebi:18012;chebi:18012 inchikey:VZCYOOQTPOCHFL-OWOJBTEDSA-N -Malate Metabolite cas:6915-15-7 wikidata:Q190143 chebi:6650;chebi:6650 inchikey:BJEPYKJPYRNKOW-UHFFFAOYSA-N -Glyoxylate Metabolite hmdb:HMDB0000119 chebi:16891;chebi:16891 inchikey:HHLFWLYXYJOTON-UHFFFAOYSA-N -alpha-ketoglutarate Metabolite hmdb:HMDB0000208 chebi:30915;chebi:30915 inchikey:KPGXRSRHYNQIFN-UHFFFAOYSA-N -Succinate Metabolite hmdb:HMDB0000254 chebi:15741;chebi:15741 inchikey:KDYFGRWQOYBRFD-UHFFFAOYSA-N -Acetyl-CoA Metabolite cas:72-89-9 wikidata:Q715317 chebi:15351;chebi:15351 inchikey:ZSLZBFCDCINBPY-ZSJPKINUSA-N -Succinyl-CoA Metabolite cas:604-98-8 wikidata:Q419560 chebi:15380;chebi:15380 inchikey:VNOYUJKHFWYWIR-ITIYDSSPSA-N -Citrate Metabolite chemspider:29081 wikidata:Q55503059 chebi:16947;chebi:16947 inchikey:KRKNYBCHXYNGOX-UHFFFAOYSA-K -Pyruvate Metabolite hmdb:HMDB0000243 chebi:32816;chebi:32816 inchikey:LCTONWCANYUPML-UHFFFAOYSA-N -Oxaloacetate Metabolite hmdb:HMDB0000223 chebi:30744;chebi:30744 inchikey:KHPXUQMNIQBQEV-UHFFFAOYSA-N -Acetyl-CoA Metabolite cas:72-89-9 wikidata:Q715317 chebi:15351;chebi:15351 inchikey:ZSLZBFCDCINBPY-ZSJPKINUSA-N -FBP1 GeneProduct ensembl:YLR377C ensembl:YLR377C ncbigene:851092 uniprot:P09201 -PFK1 GeneProduct ensembl:YGR240C ensembl:YGR240C ncbigene:853155 uniprot:P16861 -PGI1 GeneProduct ensembl:YBR196C ensembl:YBR196C ncbigene:852495 uniprot:P12709 -PCK1 GeneProduct ensembl:YKR097W ensembl:YKR097W ncbigene:853972 uniprot:P10963 -ACS2 GeneProduct ensembl:YLR153C ensembl:YLR153C ncbigene:850846 uniprot:P52910 -GND1 GeneProduct ensembl:YHR183W ensembl:YHR183W ncbigene:856589 uniprot:P38720 -TKL2 GeneProduct ensembl:YBR117C ensembl:YBR117C ncbigene:852414 uniprot:P33315 -GND2 GeneProduct ensembl:YGR256W ensembl:YGR256W ncbigene:853172 uniprot:P53319 -ADH1 GeneProduct ensembl:YOL086C ensembl:YOL086C ncbigene:854068 uniprot:P00330 -GLK1 GeneProduct ensembl:YCL040W ensembl:YCL040W ncbigene:850317 uniprot:P17709 -PYC1 GeneProduct ensembl:YGL062W ensembl:YGL062W ncbigene:852818 uniprot:P11154 -FBA1 GeneProduct ensembl:YKL060C ensembl:YKL060C ncbigene:853805 uniprot:P14540 -SOL3 GeneProduct ensembl:YHR163W ensembl:YHR163W ncbigene:856568 uniprot:P38858 -MDH3 GeneProduct ensembl:YDL078C ensembl:YDL078C ncbigene:851481 uniprot:P32419 -GPD2 GeneProduct ensembl:YOL059W ensembl:YOL059W ncbigene:854095 uniprot:P41911 -CDC19 GeneProduct ensembl:YAL038W ensembl:YAL038W ncbigene:851193 uniprot:P00549 -HOR2 GeneProduct ensembl:YER062C ensembl:YER062C ncbigene:856791 uniprot:P40106 -PDC5 GeneProduct ensembl:YLR134W ensembl:YLR134W ncbigene:850825 uniprot:P16467 -PYC2 GeneProduct ensembl:YBR218C ensembl:YBR218C ncbigene:852519 uniprot:P32327 -PGK1 GeneProduct ensembl:YCR012W ensembl:YCR012W ncbigene:850370 uniprot:P00560 -RKI1 GeneProduct ensembl:YOR095C ensembl:YOR095C ncbigene:854262 uniprot:Q12189 -GPM1 GeneProduct ensembl:YKL152C ensembl:YKL152C ncbigene:853705 uniprot:P00950 -TKL1 GeneProduct ensembl:YPR074C ensembl:YPR074C ncbigene:856188 uniprot:P23254 -ENO2 GeneProduct ensembl:YHR174W ensembl:YHR174W ncbigene:856579 uniprot:P00925 -HXK1 GeneProduct ensembl:YFR053C ensembl:YFR053C ncbigene:850614 uniprot:P04806 -TDH1 GeneProduct ensembl:YJL052W ensembl:YJL052W ncbigene:853395 uniprot:P00360 -PDC6 GeneProduct ensembl:YGR087C ensembl:YGR087C ncbigene:852978 uniprot:P26263 -ALD6 GeneProduct ensembl:YPL061W ensembl:YPL061W ncbigene:856044 uniprot:P54115 -ACS1 (mt) GeneProduct ensembl:YAL054C ensembl:YAL054C ncbigene:851245 uniprot:Q01574 -ADH4 (mt) GeneProduct ensembl:YGL256W ensembl:YGL256W ncbigene:852636 uniprot:P10127 -RPE1 GeneProduct ensembl:YJL121C ensembl:YJL121C ncbigene:853322 uniprot:P46969 -TKL2 GeneProduct ensembl:YBR117C ensembl:YBR117C ncbigene:852414 uniprot:P33315 -RHR2 GeneProduct ensembl:YIL053W ensembl:YIL053W ncbigene:854758 uniprot:P41277 -ZWF1 GeneProduct ensembl:YNL241C ensembl:YNL241C ncbigene:855480 uniprot:P11412 -GPD1 GeneProduct ensembl:YDL022W ensembl:YDL022W ncbigene:851539 uniprot:Q00055 -TDH3 GeneProduct ensembl:YGR192C ensembl:YGR192C ncbigene:853106 uniprot:P00359 -PDC1 GeneProduct ensembl:YLR044C ensembl:YLR044C ncbigene:850733 uniprot:P06169 -GUT1 GeneProduct ensembl:YHL032C ensembl:YHL032C ncbigene:856353 uniprot:P32190 -TKL1 GeneProduct ensembl:YPR074C ensembl:YPR074C ncbigene:856188 uniprot:P23254 -SOL4 GeneProduct ensembl:YGR248W ensembl:YGR248W ncbigene:853163 uniprot:P53315 -TAL1 GeneProduct ensembl:YLR354C ensembl:YLR354C ncbigene:851068 uniprot:P15019 -ADH5 GeneProduct ensembl:YBR145W ensembl:YBR145W ncbigene:852442 uniprot:P38113 -MDH2 GeneProduct ensembl:YOL126C ensembl:YOL126C ncbigene:853994 uniprot:P22133 -ADH2 GeneProduct ensembl:YMR303C ensembl:YMR303C ncbigene:855349 uniprot:P00331 -TDH2 GeneProduct ensembl:YJR009C ensembl:YJR009C ncbigene:853465 uniprot:P00358 -ENO1 GeneProduct ensembl:YGR254W ensembl:YGR254W ncbigene:853169 uniprot:P00924 -PFK2 GeneProduct ensembl:YMR205C ensembl:YMR205C ncbigene:855245 uniprot:P16862 -HXK2 GeneProduct ensembl:YGL253W ensembl:YGL253W ncbigene:852639 uniprot:P04807 -ALD4 (mt) GeneProduct ensembl:YOR374W ensembl:YOR374W ncbigene:854556 uniprot:P46367 -GUT2 GeneProduct ensembl:YIL155C ensembl:YIL155C ncbigene:854651 uniprot:P32191 -ADH3 (mt) GeneProduct ensembl:YMR083W ensembl:YMR083W ncbigene:855107 uniprot:P07246 -TPI1 GeneProduct ensembl:YDR050C ensembl:YDR050C ncbigene:851620 uniprot:P00942 -PYK2 GeneProduct ensembl:YOR347C ensembl:YOR347C ncbigene:854529 uniprot:P52489 -CIT3 GeneProduct ensembl:YPR001W ensembl:YPR001W ncbigene:856107 uniprot:P43635 -SDH4 GeneProduct ensembl:YDR178W ensembl:YDR178W ncbigene:851758 uniprot:P37298 -LPD1 GeneProduct ensembl:YFL018C ensembl:YFL018C ncbigene:850527 uniprot:P09624 -CIT1 GeneProduct ensembl:YNR001C ensembl:YNR001C ncbigene:855732 uniprot:P00890 -SDH3 GeneProduct ensembl:YKL141W ensembl:YKL141W ncbigene:853716 uniprot:P33421 -SDH2 GeneProduct ensembl:YLL041C ensembl:YLL041C ncbigene:850685 uniprot:P21801 -IDP1 GeneProduct ensembl:YDL066W ensembl:YDL066W ncbigene:851493 uniprot:P21954 -SDH1 GeneProduct ensembl:YKL148C ensembl:YKL148C ncbigene:853709 uniprot:Q00711 -LSC1 GeneProduct ensembl:YOR142W ensembl:YOR142W ncbigene:854310 uniprot:P53598 -MDH1 GeneProduct ensembl:YKL085W ensembl:YKL085W ncbigene:853777 uniprot:P17505 -LSC2 GeneProduct ensembl:YGR244C ensembl:YGR244C ncbigene:853159 uniprot:P53312 -IDH2 GeneProduct ensembl:YOR136W ensembl:YOR136W ncbigene:854303 uniprot:P28241 -LPD1 GeneProduct ensembl:YFL018C ensembl:YFL018C ncbigene:850527 uniprot:P09624 -FUM1 GeneProduct ensembl:YPL262W ensembl:YPL262W ncbigene:855866 uniprot:P08417 -IDP2 GeneProduct ensembl:YLR174W ensembl:YLR174W ncbigene:850871 uniprot:P41939 -PDX1 GeneProduct ensembl:YGR193C ensembl:YGR193C ncbigene:853107 uniprot:P16451 -ACO2 GeneProduct ensembl:YJL200C ensembl:YJL200C ncbigene:853230 uniprot:P39533 -LAT1 GeneProduct ensembl:YNL071W ensembl:YNL071W ncbigene:855653 uniprot:P12695 -PDB1 GeneProduct ensembl:YBR221C ensembl:YBR221C ncbigene:852522 uniprot:P32473 -MAE1 GeneProduct ensembl:YKL029C ensembl:YKL029C ncbigene:853839 uniprot:P36013 -CIT2 GeneProduct ensembl:YCR005C ensembl:YCR005C ncbigene:850361 uniprot:P08679 -PDA1 GeneProduct ensembl:YER178W ensembl:YER178W ncbigene:856925 uniprot:P16387 -DAL7 GeneProduct ensembl:YIR031C ensembl:YIR031C ncbigene:854849 uniprot:P21826 -KGD2 GeneProduct ensembl:YDR148C ensembl:YDR148C ncbigene:851726 uniprot:P19262 -KGD1 GeneProduct ensembl:YIL125W ensembl:YIL125W ncbigene:854681 uniprot:P20967 -IDH1 GeneProduct ensembl:YNL037C ensembl:YNL037C ncbigene:855691 uniprot:P28834 -ICL1 GeneProduct ensembl:YER065C peroxisome
Type your comment here ensembl:YER065C ncbigene:856794 uniprot:P28240 -MLS1 GeneProduct ensembl:YNL117W peroxisome
Type your comment here ensembl:YNL117W ncbigene:855606 uniprot:P30952 -ACO1 GeneProduct ensembl:YLR304C ensembl:YLR304C ncbigene:851013 uniprot:P19414 +Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps +2-Phosphoglycerate Metabolite cas:2553-59-5 "" wikidata:Q209469 chebi:24344 inchikey:GXIURPTVHJPJLF-UHFFFAOYSA-N pubchem.compound:59 chemspider:58 hmdb:HMDB0000362 +Fructose 1,6-bisphosphate Metabolite cas:488-69-7 "" wikidata:Q414945;wikidata:Q28529691 chebi:28013;chebi:16905;chebi:37736 inchikey:RNBGYGVWRKECFJ-ARQDHWQXSA-N;inchikey:XPYBSIWDXQFNMH-UYFOZJQFSA-N pubchem.compound:10267;pubchem.compound:84951 chemspider:9848;chemspider:76632 kegg.compound:C05378;kegg.compound:C00354 +Glucose-6-phosphate Metabolite cas:59-56-3 "" wikidata:Q418865 chebi:29042 inchikey:HXXFSFRBOHSIMQ-VFUOTHLCSA-N pubchem.compound:65533 chemspider:58977 hmdb:HMDB0001586 kegg.compound:C00103 +Glyceraldehyde-3-phosphate Metabolite chebi:17138 "" wikidata:Q794810 chebi:17138 inchikey:LXJXRIRHZLFYRP-UHFFFAOYSA-N pubchem.compound:729 chemspider:709 hmdb:HMDB0001112 kegg.compound:C00661 +D-6-Phospho-glucono-delta-lactone Metabolite cas:90-80-2 "" wikidata:Q114174 chebi:16217 inchikey:PHOQVHQSTUBQQK-SQOUGZDYSA-N pubchem.compound:7027 chemspider:6760 hmdb:HMDB0000150 kegg.compound:C00198 +Acetate Metabolite cas:64-19-7 "" wikidata:Q47512 chebi:15366 inchikey:QTBSBXVTEAMEQO-UHFFFAOYSA-N pubchem.compound:176 chemspider:171 hmdb:HMDB0000042 kegg.compound:C00033 lipidmaps:LMFA01010002 +Oxaloacetate Metabolite cas:328-42-7 "" wikidata:Q408658 chebi:30744 inchikey:KHPXUQMNIQBQEV-UHFFFAOYSA-N pubchem.compound:970 chemspider:945 hmdb:HMDB0000223 kegg.compound:C00036 lipidmaps:LMFA01170061;lipidmaps:LMFA01170120 +Glucose Metabolite wikidata:Q37525 "" wikidata:Q37525 chebi:17234 +Phosphoenolpyruvate Metabolite cas:138-08-9 "" wikidata:Q412139 chebi:44897 inchikey:DTBNBXWJWCWCIK-UHFFFAOYSA-N pubchem.compound:1005 chemspider:980 hmdb:HMDB0000263 kegg.compound:C00074 +Acetaldehyde Metabolite cas:75-07-0 "" wikidata:Q61457 chebi:15343 inchikey:IKHGUXGNUITLKF-UHFFFAOYSA-N;inchikey:WGYWEDJQQFKGID-ZTKYFMRJSA-O;inchikey:MBSKDCPWFSMEFD-ZKVZURMCSA-O pubchem.compound:177 chemspider:172 hmdb:HMDB0000990;hmdb:HMDB0301662;hmdb:HMDB0301661 kegg.compound:C00084 +Ethanol Metabolite cas:64-17-5 "" wikidata:Q153 chebi:16236 inchikey:LFQSCWFLJHTTHZ-UHFFFAOYSA-N pubchem.compound:702 chemspider:682 hmdb:HMDB0000108 kegg.compound:C00469 +Glycerol 3-phosphate Metabolite cas:57-03-4 "" wikidata:Q2739882 chebi:14336;chebi:15978 inchikey:AWUCVROLDVIAJX-UHFFFAOYSA-N;inchikey:AWUCVROLDVIAJX-GSVOUGTGSA-N pubchem.compound:439162;pubchem.compound:754 chemspider:388308;chemspider:734 hmdb:HMDB0000126 kegg.compound:C00093;kegg.compound:C03189 +Acetyl-CoA Metabolite cas:72-89-9 "" wikidata:Q715317 chebi:15351 inchikey:ZSLZBFCDCINBPY-ZSJPKINUSA-N pubchem.compound:444493 chemspider:392413 hmdb:HMDB0001206 kegg.compound:C00024 lipidmaps:LMFA07050281 +Phosphate Metabolite cas:14265-44-2 "" wikidata:Q177811 chebi:26078;chebi:18367 inchikey:NBIIXXVUZAFLBC-UHFFFAOYSA-K;inchikey:NBIIXXVUZAFLBC-UHFFFAOYSA-N pubchem.compound:1004;pubchem.compound:1061 chemspider:979;chemspider:1032 hmdb:HMDB0001429 kegg.compound:C00009 +3-Phosphoglycerate Metabolite cas:820-11-1 "" wikidata:Q32904835 chebi:17050 inchikey:OSJPPGNTCRNQQC-UHFFFAOYSA-N pubchem.compound:724 chemspider:704 hmdb:HMDB0000807 kegg.compound:C00597 +D-Ribose-5-Phosphate Metabolite cas:3615-55-2 "" wikidata:Q27125661 chebi:58273 inchikey:PPQRONHOSHZGFQ-LMVFSUKVSA-L pubchem.compound:21115541 chemspider:19971025 +Fructose-6-phosphate Metabolite cas:643-13-0 "" wikidata:Q32039197 chebi:15946;chebi:61553 inchikey:GSXOAOHZAIYLCY-HSUXUTPPSA-N pubchem.compound:69507 chemspider:62713 hmdb:HMDB0000124 kegg.compound:C00085 +6-Phosphogluconate Metabolite cas:921-62-0 "" wikidata:Q245501 chebi:48928 inchikey:BIRSGZKFKXLSJQ-SQOUGZDYSA-N pubchem.compound:91493 chemspider:82615 hmdb:HMDB0001316 kegg.compound:C00345 +Glycerol Metabolite cas:56-81-5 "" wikidata:Q132501 chebi:17754 inchikey:PEDCQBHIVMGVHV-UHFFFAOYSA-N pubchem.compound:753 chemspider:733 hmdb:HMDB0000131 kegg.compound:C00116 +Dihydroxyacetone Metabolite cas:96-26-4 "" wikidata:Q409618 chebi:16016 inchikey:RXKJFZQQPQGTFL-UHFFFAOYSA-N pubchem.compound:670 chemspider:650 hmdb:HMDB0001882 kegg.compound:C00184 +Erythrose-4-phosphate Metabolite cas:585-18-2 "" wikidata:Q32039231 chebi:48153 inchikey:NGHMDNPXVRFFGS-IUYQGCFVSA-N pubchem.compound:122357 chemspider:109096 hmdb:HMDB0001321 kegg.compound:C00279 +Ribulose-5-phosphate Metabolite cas:4151-19-3 "" wikidata:Q418886 chebi:17666;chebi:17363;chebi:37455;chebi:17797 inchikey:FNZLKVNUWIIPSJ-UHNVWZDZSA-N pubchem.compound:439184 chemspider:388327 hmdb:HMDB0000618 kegg.compound:C01101;kegg.compound:C00117;kegg.compound:C00199 +Malate Metabolite cas:6915-15-7 "" wikidata:Q190143 chebi:6650 inchikey:BJEPYKJPYRNKOW-UHFFFAOYSA-N pubchem.compound:525 chemspider:510 hmdb:HMDB0000744 kegg.compound:C00711 +Pyruvate Metabolite cas:127-17-3 "" wikidata:Q213580 chebi:32816 inchikey:LCTONWCANYUPML-UHFFFAOYSA-N pubchem.compound:1060 chemspider:1031 hmdb:HMDB0000243 kegg.compound:C00022 lipidmaps:LMFA01060077 +Sedoheptulose-7-phosphate Metabolite cas:2646-35-7 "" wikidata:Q3040325 chebi:15721 inchikey:JDTUMPKOJBQPKX-GBNDHIKLSA-N pubchem.compound:165007 chemspider:144663 hmdb:HMDB0001068 kegg.compound:C00281;kegg.compound:C05382 +1,3-Bisphosphoglycerate Metabolite cas:1981-49-3 "" wikidata:Q1020557 chebi:89363 inchikey:LJQLQCAXBUHEAZ-UHFFFAOYSA-N pubchem.compound:683 chemspider:21230406;chemspider:663 hmdb:HMDB0001270 +Xylulose-5-phosphate Metabolite cas:60802-29-1 "" wikidata:Q37864045 chebi:27354 inchikey:FNZLKVNUWIIPSJ-UHFFFAOYSA-N pubchem.compound:850 kegg.compound:C00231 +Isocitrate Metabolite cas:320-77-4 "" wikidata:Q288927 chebi:30887 inchikey:ODBLHEXUDAPZAU-UHFFFAOYSA-N pubchem.compound:1198 chemspider:1161 hmdb:HMDB0000193 kegg.compound:C00311 +Fumarate Metabolite hmdb:HMDB0000134 "" chebi:18012 inchikey:VZCYOOQTPOCHFL-OWOJBTEDSA-N pubchem.compound:444972 chemspider:10197150 hmdb:HMDB0000134 kegg.compound:C00122 +Glyoxylate Metabolite hmdb:HMDB0000119 "" chebi:16891 inchikey:HHLFWLYXYJOTON-UHFFFAOYSA-N pubchem.compound:760 chemspider:740 hmdb:HMDB0000119 kegg.compound:C00048 +alpha-ketoglutarate Metabolite hmdb:HMDB0000208 "" chebi:30915 inchikey:KPGXRSRHYNQIFN-UHFFFAOYSA-N pubchem.compound:51 chemspider:50 hmdb:HMDB0000208 kegg.compound:C00026 +Succinate Metabolite hmdb:HMDB0000254 "" chebi:15741 inchikey:KDYFGRWQOYBRFD-UHFFFAOYSA-N pubchem.compound:1738118 chemspider:1078 hmdb:HMDB0000254 kegg.compound:C00042 +Succinyl-CoA Metabolite cas:604-98-8 "" wikidata:Q419560 chebi:15380 inchikey:VNOYUJKHFWYWIR-ITIYDSSPSA-N pubchem.compound:92133 chemspider:83179 hmdb:HMDB0001022 kegg.compound:C00091 lipidmaps:LMFA07050370 +Citrate Metabolite chemspider:29081 "" wikidata:Q55503059 chebi:16947 inchikey:KRKNYBCHXYNGOX-UHFFFAOYSA-K pubchem.compound:31348 chemspider:29081 +Pyruvate Metabolite hmdb:HMDB0000243 "" chebi:32816 inchikey:LCTONWCANYUPML-UHFFFAOYSA-N pubchem.compound:1060 hmdb:HMDB0000243 kegg.compound:C00022 +Oxaloacetate Metabolite hmdb:HMDB0000223 "" chebi:30744 inchikey:KHPXUQMNIQBQEV-UHFFFAOYSA-N pubchem.compound:970 chemspider:945 hmdb:HMDB0000223 kegg.compound:C00036 +FBP1 GeneProduct ensembl:YLR377C "" ensembl:YLR377C ncbigene:851092 uniprot:P09201 +PFK1 GeneProduct ensembl:YGR240C "" ensembl:YGR240C ncbigene:853155 uniprot:P16861 +PGI1 GeneProduct ensembl:YBR196C "" ensembl:YBR196C ncbigene:852495 uniprot:P12709 +PCK1 GeneProduct ensembl:YKR097W "" ensembl:YKR097W ncbigene:853972 uniprot:P10963 +ACS2 GeneProduct ensembl:YLR153C "" ensembl:YLR153C ncbigene:850846 uniprot:P52910 +GND1 GeneProduct ensembl:YHR183W "" ensembl:YHR183W ncbigene:856589 uniprot:P38720 +TKL2 GeneProduct ensembl:YBR117C "" ensembl:YBR117C ncbigene:852414 uniprot:P33315 +GND2 GeneProduct ensembl:YGR256W "" ensembl:YGR256W ncbigene:853172 uniprot:P53319 +ADH1 GeneProduct ensembl:YOL086C "" ensembl:YOL086C ncbigene:854068 uniprot:P00330 +GLK1 GeneProduct ensembl:YCL040W "" ensembl:YCL040W ncbigene:850317 uniprot:P17709 +PYC1 GeneProduct ensembl:YGL062W "" ensembl:YGL062W ncbigene:852818 uniprot:P11154 +FBA1 GeneProduct ensembl:YKL060C "" ensembl:YKL060C ncbigene:853805 uniprot:P14540 +SOL3 GeneProduct ensembl:YHR163W "" ensembl:YHR163W ncbigene:856568 uniprot:P38858 +MDH3 GeneProduct ensembl:YDL078C "" ensembl:YDL078C ncbigene:851481 uniprot:P32419 +GPD2 GeneProduct ensembl:YOL059W "" ensembl:YOL059W ncbigene:854095 uniprot:P41911 +CDC19 GeneProduct ensembl:YAL038W "" ensembl:YAL038W ncbigene:851193 uniprot:P00549 +HOR2 GeneProduct ensembl:YER062C "" ensembl:YER062C ncbigene:856791 uniprot:P40106 +PDC5 GeneProduct ensembl:YLR134W "" ensembl:YLR134W ncbigene:850825 uniprot:P16467 +PYC2 GeneProduct ensembl:YBR218C "" ensembl:YBR218C ncbigene:852519 uniprot:P32327 +PGK1 GeneProduct ensembl:YCR012W "" ensembl:YCR012W ncbigene:850370 uniprot:P00560 +RKI1 GeneProduct ensembl:YOR095C "" ensembl:YOR095C ncbigene:854262 uniprot:Q12189 +GPM1 GeneProduct ensembl:YKL152C "" ensembl:YKL152C ncbigene:853705 uniprot:P00950 +TKL1 GeneProduct ensembl:YPR074C "" ensembl:YPR074C ncbigene:856188 uniprot:P23254 +ENO2 GeneProduct ensembl:YHR174W "" ensembl:YHR174W ncbigene:856579 uniprot:P00925 +HXK1 GeneProduct ensembl:YFR053C "" ensembl:YFR053C ncbigene:850614 uniprot:P04806 +TDH1 GeneProduct ensembl:YJL052W "" ensembl:YJL052W ncbigene:853395 uniprot:P00360 +PDC6 GeneProduct ensembl:YGR087C "" ensembl:YGR087C ncbigene:852978 uniprot:P26263 +ALD6 GeneProduct ensembl:YPL061W "" ensembl:YPL061W ncbigene:856044 uniprot:P54115 +ACS1 (mt) GeneProduct ensembl:YAL054C "" ensembl:YAL054C ncbigene:851245 uniprot:Q01574 +ADH4 (mt) GeneProduct ensembl:YGL256W "" ensembl:YGL256W ncbigene:852636 uniprot:P10127 +RPE1 GeneProduct ensembl:YJL121C "" ensembl:YJL121C ncbigene:853322 uniprot:P46969 +RHR2 GeneProduct ensembl:YIL053W "" ensembl:YIL053W ncbigene:854758 uniprot:P41277 +ZWF1 GeneProduct ensembl:YNL241C "" ensembl:YNL241C ncbigene:855480 uniprot:P11412 +GPD1 GeneProduct ensembl:YDL022W "" ensembl:YDL022W ncbigene:851539 uniprot:Q00055 +TDH3 GeneProduct ensembl:YGR192C "" ensembl:YGR192C ncbigene:853106 uniprot:P00359 +PDC1 GeneProduct ensembl:YLR044C "" ensembl:YLR044C ncbigene:850733 uniprot:P06169 +GUT1 GeneProduct ensembl:YHL032C "" ensembl:YHL032C ncbigene:856353 uniprot:P32190 +SOL4 GeneProduct ensembl:YGR248W "" ensembl:YGR248W ncbigene:853163 uniprot:P53315 +TAL1 GeneProduct ensembl:YLR354C "" ensembl:YLR354C ncbigene:851068 uniprot:P15019 +ADH5 GeneProduct ensembl:YBR145W "" ensembl:YBR145W ncbigene:852442 uniprot:P38113 +MDH2 GeneProduct ensembl:YOL126C "" ensembl:YOL126C ncbigene:853994 uniprot:P22133 +ADH2 GeneProduct ensembl:YMR303C "" ensembl:YMR303C ncbigene:855349 uniprot:P00331 +TDH2 GeneProduct ensembl:YJR009C "" ensembl:YJR009C ncbigene:853465 uniprot:P00358 +ENO1 GeneProduct ensembl:YGR254W "" ensembl:YGR254W ncbigene:853169 uniprot:P00924 +PFK2 GeneProduct ensembl:YMR205C "" ensembl:YMR205C ncbigene:855245 uniprot:P16862 +HXK2 GeneProduct ensembl:YGL253W "" ensembl:YGL253W ncbigene:852639 uniprot:P04807 +ALD4 (mt) GeneProduct ensembl:YOR374W "" ensembl:YOR374W ncbigene:854556 uniprot:P46367 +GUT2 GeneProduct ensembl:YIL155C "" ensembl:YIL155C ncbigene:854651 uniprot:P32191 +ADH3 (mt) GeneProduct ensembl:YMR083W "" ensembl:YMR083W ncbigene:855107 uniprot:P07246 +TPI1 GeneProduct ensembl:YDR050C "" ensembl:YDR050C ncbigene:851620 uniprot:P00942 +PYK2 GeneProduct ensembl:YOR347C "" ensembl:YOR347C ncbigene:854529 uniprot:P52489 +CIT3 GeneProduct ensembl:YPR001W "" ensembl:YPR001W ncbigene:856107 uniprot:P43635 +SDH4 GeneProduct ensembl:YDR178W "" ensembl:YDR178W ncbigene:851758 uniprot:P37298 +LPD1 GeneProduct ensembl:YFL018C "" ensembl:YFL018C ncbigene:850527 uniprot:P09624 +CIT1 GeneProduct ensembl:YNR001C "" ensembl:YNR001C ncbigene:855732 uniprot:P00890 +SDH3 GeneProduct ensembl:YKL141W "" ensembl:YKL141W ncbigene:853716 uniprot:P33421 +SDH2 GeneProduct ensembl:YLL041C "" ensembl:YLL041C ncbigene:850685 uniprot:P21801 +IDP1 GeneProduct ensembl:YDL066W "" ensembl:YDL066W ncbigene:851493 uniprot:P21954 +SDH1 GeneProduct ensembl:YKL148C "" ensembl:YKL148C ncbigene:853709 uniprot:Q00711 +LSC1 GeneProduct ensembl:YOR142W "" ensembl:YOR142W ncbigene:854310 uniprot:P53598 +MDH1 GeneProduct ensembl:YKL085W "" ensembl:YKL085W ncbigene:853777 uniprot:P17505 +LSC2 GeneProduct ensembl:YGR244C "" ensembl:YGR244C ncbigene:853159 uniprot:P53312 +IDH2 GeneProduct ensembl:YOR136W "" ensembl:YOR136W ncbigene:854303 uniprot:P28241 +FUM1 GeneProduct ensembl:YPL262W "" ensembl:YPL262W ncbigene:855866 uniprot:P08417 +IDP2 GeneProduct ensembl:YLR174W "" ensembl:YLR174W ncbigene:850871 uniprot:P41939 +PDX1 GeneProduct ensembl:YGR193C "" ensembl:YGR193C ncbigene:853107 uniprot:P16451 +ACO2 GeneProduct ensembl:YJL200C "" ensembl:YJL200C ncbigene:853230 uniprot:P39533 +LAT1 GeneProduct ensembl:YNL071W "" ensembl:YNL071W ncbigene:855653 uniprot:P12695 +PDB1 GeneProduct ensembl:YBR221C "" ensembl:YBR221C ncbigene:852522 uniprot:P32473 +MAE1 GeneProduct ensembl:YKL029C "" ensembl:YKL029C ncbigene:853839 uniprot:P36013 +CIT2 GeneProduct ensembl:YCR005C "" ensembl:YCR005C ncbigene:850361 uniprot:P08679 +PDA1 GeneProduct ensembl:YER178W "" ensembl:YER178W ncbigene:856925 uniprot:P16387 +DAL7 GeneProduct ensembl:YIR031C "" ensembl:YIR031C ncbigene:854849 uniprot:P21826 +KGD2 GeneProduct ensembl:YDR148C "" ensembl:YDR148C ncbigene:851726 uniprot:P19262 +KGD1 GeneProduct ensembl:YIL125W "" ensembl:YIL125W ncbigene:854681 uniprot:P20967 +IDH1 GeneProduct ensembl:YNL037C "" ensembl:YNL037C ncbigene:855691 uniprot:P28834 +ICL1 GeneProduct ensembl:YER065C "peroxisome
Type your comment here" ensembl:YER065C ncbigene:856794 uniprot:P28240 +MLS1 GeneProduct ensembl:YNL117W "peroxisome
Type your comment here" ensembl:YNL117W ncbigene:855606 uniprot:P30952 +ACO1 GeneProduct ensembl:YLR304C "" ensembl:YLR304C ncbigene:851013 uniprot:P19414 diff --git a/pathways/WP112/WP112.gpml b/pathways/WP112/WP112.gpml index 5dc1c75c1..1209dd4cd 100644 --- a/pathways/WP112/WP112.gpml +++ b/pathways/WP112/WP112.gpml @@ -1,7 +1,7 @@ - + Based on Glycolysis and Gluconeogenesis Pathways at SGD and on Kruckeberg, AL and Dickinson, JR (2004) Carbon Metabolism in The Metabolism and Molecular Physiology of Saccharomyces cerevisiae, Dickinson, JR and Schweizer, M, eds, CRC Press. - + @@ -562,795 +562,795 @@ - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - - - + + + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - - + + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + @@ -1358,8 +1358,8 @@ - - + + @@ -1367,23 +1367,23 @@ - - + + - - + + - - + + @@ -1391,94 +1391,94 @@ - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + @@ -1524,33 +1524,33 @@ - + - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1560,3 +1560,4 @@ + diff --git a/pathways/WP112/WP112.json b/pathways/WP112/WP112.json index 4080800bf..30994e197 100644 --- a/pathways/WP112/WP112.json +++ b/pathways/WP112/WP112.json @@ -10,7 +10,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a00", - "isPartOf": "d297c", + "isPartOf": "a0366", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -42,6 +42,35 @@ "y": 8, "zIndex": 32886 }, + "a0366": { + "contains": [ + "a25", + "a00" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "a0366", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 56, + "x": 695.1335436382752, + "y": 330.2544689800214, + "zIndex": 32864 + }, "a04a4": { "drawAs": "rect", "fill": "#ffffff", @@ -71,8 +100,12 @@ "Succinyl-CoA", "Wikidata:Q419560", "ChEBI:15380", - "ChEBI:15380", - "InChI:VNOYUJKHFWYWIR-ITIYDSSPSA-N" + "InChI:VNOYUJKHFWYWIR-ITIYDSSPSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -113,8 +146,12 @@ "Acetyl-CoA", "Wikidata:Q715317", "ChEBI:15351", - "ChEBI:15351", - "InChI:ZSLZBFCDCINBPY-ZSJPKINUSA-N" + "InChI:ZSLZBFCDCINBPY-ZSJPKINUSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -161,7 +198,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a25", - "isPartOf": "d297c", + "isPartOf": "a0366", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -204,7 +241,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a26", - "isPartOf": "affe3", + "isPartOf": "cb175", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -326,8 +363,11 @@ "Ethanol", "Wikidata:Q153", "ChEBI:16236", - "ChEBI:16236", - "InChI:LFQSCWFLJHTTHZ-UHFFFAOYSA-N" + "InChI:LFQSCWFLJHTTHZ-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -368,8 +408,11 @@ "Malate", "Wikidata:Q190143", "ChEBI:6650", - "ChEBI:6650", - "InChI:BJEPYKJPYRNKOW-UHFFFAOYSA-N" + "InChI:BJEPYKJPYRNKOW-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -381,6 +424,37 @@ "y": 1693.4329438967982, "zIndex": 33012 }, + "a547f": { + "contains": [ + "e3a32", + "dd1df", + "cf015", + "e7272" + ], + "drawAs": "rect", + "fill": "#b4b464", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 98, + "id": "a547f", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 1, + "textAlign": "center", + "type": [ + "Group", + "GroupNone" + ], + "verticalAlign": "middle", + "width": 59.66666666666663, + "x": 551.5697011290268, + "y": 1892.537827566498, + "zIndex": 32996 + }, "a555b": { "drawAs": "rect", "fill": "#ffffff", @@ -410,8 +484,11 @@ "1,3-Bisphosphoglycerate", "Wikidata:Q1020557", "ChEBI:89363", - "ChEBI:89363", - "InChI:LJQLQCAXBUHEAZ-UHFFFAOYSA-N" + "InChI:LJQLQCAXBUHEAZ-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -434,7 +511,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a5d", - "isPartOf": "de691", + "isPartOf": "c2d9f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -494,8 +571,10 @@ "CompactIdentifier:hmdb:HMDB0000243", "Pyruvate", "ChEBI:32816", - "ChEBI:32816", - "InChI:LCTONWCANYUPML-UHFFFAOYSA-N" + "InChI:LCTONWCANYUPML-UHFFFAOYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -532,35 +611,6 @@ "width": 0, "zIndex": 12288 }, - "a700a": { - "contains": [ - "dfb", - "e64" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "a700a", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 59.33333333333334, - "x": 10.383490131487154, - "y": 514.9429664163484, - "zIndex": 32812 - }, "a7146": { "backpageHead": "PDX1", "drawAs": "rect", @@ -572,7 +622,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a7146", - "isPartOf": "aa47f", + "isPartOf": "d678d", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -633,8 +683,9 @@ "D-Ribose-5-Phosphate", "Wikidata:Q27125661", "ChEBI:58273", - "ChEBI:58273", - "InChI:PPQRONHOSHZGFQ-LMVFSUKVSA-L" + "InChI:PPQRONHOSHZGFQ-LMVFSUKVSA-L", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -687,7 +738,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a90", - "isPartOf": "efab8", + "isPartOf": "f63a0", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -789,8 +840,11 @@ "Isocitrate", "Wikidata:Q288927", "ChEBI:30887", - "ChEBI:30887", - "InChI:ODBLHEXUDAPZAU-UHFFFAOYSA-N" + "InChI:ODBLHEXUDAPZAU-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -838,7 +892,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "aa2", - "isPartOf": "b022f", + "isPartOf": "b5ba3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -870,38 +924,6 @@ "y": 27.999999999999773, "zIndex": 32932 }, - "aa47f": { - "contains": [ - "b1a2a", - "a7146", - "fc4c0", - "b2546", - "fc09e" - ], - "drawAs": "Octagon", - "fill": "#b4b464", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 124, - "id": "aa47f", - "kaavioType": "Group", - "padding": 11, - "stroke": "#808080", - "strokeWidth": 1, - "textAlign": "center", - "type": [ - "Group", - "Complex", - "GroupComplex" - ], - "verticalAlign": "middle", - "width": 90.66666666666663, - "x": 836.492917820675, - "y": 1466.096442903443, - "zIndex": 32998 - }, "aa5bd": { "burrs": [ "a9fe8" @@ -928,7 +950,6 @@ 1 ] }, - "id": "b61b3", "isAttachedTo": "d12ff", "orientation": [ 0, @@ -948,7 +969,6 @@ 0 ] }, - "id": "e8324", "isAttachedTo": "a9d1a", "orientation": [ 0, @@ -970,6 +990,35 @@ ], "zIndex": 32954 }, + "abda6": { + "contains": [ + "cfe", + "cd8" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "abda6", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 76, + "x": 103.6581799190497, + "y": 1290.591961526744, + "zIndex": 32810 + }, "ac9": { "backpageHead": "HXK2 | Hexokinase isoenzyme 2 that catalyzes ph...", "drawAs": "rect", @@ -981,7 +1030,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "ac9", - "isPartOf": "d83b4", + "isPartOf": "f6127", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1038,64 +1087,6 @@ "width": 0, "zIndex": 12288 }, - "ad054": { - "contains": [ - "b0a13", - "c9b82" - ], - "drawAs": "Octagon", - "fill": "#b4b464", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 64, - "id": "ad054", - "kaavioType": "Group", - "padding": 11, - "stroke": "#808080", - "strokeWidth": 1, - "textAlign": "center", - "type": [ - "Group", - "Complex", - "GroupComplex" - ], - "verticalAlign": "middle", - "width": 94.1807228915668, - "x": 695.4887274452622, - "y": 1791.2891366001006, - "zIndex": 33056 - }, - "ad3b9": { - "contains": [ - "be9", - "e67" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "ad3b9", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 59.33333333333337, - "x": 754.4709687742878, - "y": 68.38336281249433, - "zIndex": 32786 - }, "ad5": { "drawAs": "none", "fill": "transparent", @@ -1127,7 +1118,7 @@ "y": 147.72442505947652, "zIndex": 28676 }, - "adacc": { + "ad7e2": { "contains": [ "c95", "ed5" @@ -1139,7 +1130,7 @@ "fontWeight": "bold", "gpmlElementName": "Group", "height": 56, - "id": "adacc", + "id": "ad7e2", "kaavioType": "Group", "padding": 8, "stroke": "#808080", @@ -1156,35 +1147,6 @@ "y": 852, "zIndex": 32842 }, - "adca6": { - "contains": [ - "b44", - "b62" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "adca6", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 56, - "x": 670.5699263932703, - "y": 637.6151419558356, - "zIndex": 32790 - }, "ae8": { "drawAs": "rect", "fill": "#ffffff", @@ -1214,8 +1176,11 @@ "Glycerol", "Wikidata:Q132501", "ChEBI:17754", - "ChEBI:17754", - "InChI:PEDCQBHIVMGVHV-UHFFFAOYSA-N" + "InChI:PEDCQBHIVMGVHV-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1252,36 +1217,6 @@ "width": 0, "zIndex": 12288 }, - "ae9da": { - "contains": [ - "badff", - "f0985", - "ba9f4" - ], - "drawAs": "rect", - "fill": "#b4b464", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 77.99999999999955, - "id": "ae9da", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 1, - "textAlign": "center", - "type": [ - "Group", - "GroupNone" - ], - "verticalAlign": "middle", - "width": 61.33333333333326, - "x": 1027.3449116758563, - "y": 2031.155928662868, - "zIndex": 33034 - }, "af0de": { "drawAs": "rect", "fill": "#ffffff", @@ -1310,8 +1245,11 @@ "CompactIdentifier:hmdb:HMDB0000119", "Glyoxylate", "ChEBI:16891", - "ChEBI:16891", - "InChI:HHLFWLYXYJOTON-UHFFFAOYSA-N" + "InChI:HHLFWLYXYJOTON-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1348,64 +1286,6 @@ "width": 0, "zIndex": 12288 }, - "affe3": { - "contains": [ - "a26", - "e96" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "affe3", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 96, - "x": 1088.8560539148768, - "y": 1063.0021251197722, - "zIndex": 32858 - }, - "b022f": { - "contains": [ - "fc7", - "aa2" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 55.99999999999977, - "id": "b022f", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 76, - "x": 334.432541236889, - "y": 984.8935457196328, - "zIndex": 32814 - }, "b0499": { "attachmentDisplay": { "offset": [ @@ -1467,7 +1347,7 @@ "gpmlElementName": "DataNode", "height": 19.999999999999996, "id": "b0a13", - "isPartOf": "ad054", + "isPartOf": "dc1a8", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1510,7 +1390,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b0c", - "isPartOf": "ebe17", + "isPartOf": "d302f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1542,6 +1422,35 @@ "y": 8, "zIndex": 32776 }, + "b1633": { + "contains": [ + "dfb", + "e64" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "b1633", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 59.33333333333334, + "x": 10.383490131487154, + "y": 514.9429664163484, + "zIndex": 32812 + }, "b17": { "backpageHead": "TDH3 | Glyceraldehyde-3-phosphate dehydrogenas...", "drawAs": "rect", @@ -1553,7 +1462,7 @@ "gpmlElementName": "DataNode", "height": 19.999999999999982, "id": "b17", - "isPartOf": "d7c34", + "isPartOf": "ff97e", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1596,7 +1505,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b1a2a", - "isPartOf": "aa47f", + "isPartOf": "d678d", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1639,7 +1548,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b1e", - "isPartOf": "b9776", + "isPartOf": "db8db", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1700,8 +1609,11 @@ "Erythrose-4-phosphate", "Wikidata:Q32039231", "ChEBI:48153", - "ChEBI:48153", - "InChI:NGHMDNPXVRFFGS-IUYQGCFVSA-N" + "InChI:NGHMDNPXVRFFGS-IUYQGCFVSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1735,7 +1647,6 @@ 1 ] }, - "id": "ad405", "isAttachedTo": "bfdcf", "orientation": [ 0, @@ -1756,7 +1667,6 @@ 0 ] }, - "id": "f07d6", "isAttachedTo": "e1996", "orientation": [], "x": 800.756186163238, @@ -1782,7 +1692,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b2546", - "isPartOf": "aa47f", + "isPartOf": "d678d", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1837,7 +1747,6 @@ 0.5 ] }, - "id": "f496d", "isAttachedTo": "dc92a", "orientation": [ 1, @@ -1858,7 +1767,6 @@ 0 ] }, - "id": "fea3c", "isAttachedTo": "ae9aa", "orientation": [], "x": 611.4229402458315, @@ -1883,7 +1791,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b29ed", - "isPartOf": "fff2a", + "isPartOf": "d814c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1915,6 +1823,35 @@ "y": 9, "zIndex": 33020 }, + "b2b63": { + "contains": [ + "bf867", + "c4bc5" + ], + "drawAs": "rect", + "fill": "#b4b464", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 58, + "id": "b2b63", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 1, + "textAlign": "center", + "type": [ + "Group", + "GroupNone" + ], + "verticalAlign": "middle", + "width": 61.33333333333326, + "x": 1226.0182548375315, + "y": 1721.9115248874275, + "zIndex": 33044 + }, "b31": { "drawAs": "rect", "fill": "#ffffff", @@ -1947,14 +1884,44 @@ "UniProt:Q12189" ], "verticalAlign": "middle", - "whiteSpace": "pre", - "width": 40, - "wpType": "GeneProduct", - "x": 772.9758149316511, - "xrefDataSource": "Ensembl", - "xrefIdentifier": "YOR095C", - "y": 203.33333333333334, - "zIndex": 32830 + "whiteSpace": "pre", + "width": 40, + "wpType": "GeneProduct", + "x": 772.9758149316511, + "xrefDataSource": "Ensembl", + "xrefIdentifier": "YOR095C", + "y": 203.33333333333334, + "zIndex": 32830 + }, + "b35b3": { + "contains": [ + "e04", + "dad", + "c6b" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 76, + "id": "b35b3", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 76, + "x": 669.2660360895651, + "y": 949.5206222265043, + "zIndex": 32794 }, "b39": { "backpageHead": "PGK1 | 3-phosphoglycerate kinase catalyzes tr...", @@ -2008,7 +1975,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b44", - "isPartOf": "adca6", + "isPartOf": "c8125", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2040,37 +2007,6 @@ "y": 28, "zIndex": 32790 }, - "b45f0": { - "contains": [ - "e3a32", - "dd1df", - "cf015", - "e7272" - ], - "drawAs": "rect", - "fill": "#b4b464", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 98, - "id": "b45f0", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 1, - "textAlign": "center", - "type": [ - "Group", - "GroupNone" - ], - "verticalAlign": "middle", - "width": 59.66666666666663, - "x": 551.5697011290268, - "y": 1892.537827566498, - "zIndex": 32996 - }, "b4623": { "attachmentDisplay": { "offset": [ @@ -2125,8 +2061,11 @@ "Malate", "Wikidata:Q190143", "ChEBI:6650", - "ChEBI:6650", - "InChI:BJEPYKJPYRNKOW-UHFFFAOYSA-N" + "InChI:BJEPYKJPYRNKOW-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2167,8 +2106,12 @@ "Acetyl-CoA", "Wikidata:Q715317", "ChEBI:15351", - "ChEBI:15351", - "InChI:ZSLZBFCDCINBPY-ZSJPKINUSA-N" + "InChI:ZSLZBFCDCINBPY-ZSJPKINUSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2190,7 +2133,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b511b", - "isPartOf": "fff2a", + "isPartOf": "d814c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2222,6 +2165,35 @@ "y": 29, "zIndex": 33030 }, + "b5ba3": { + "contains": [ + "fc7", + "aa2" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 55.99999999999977, + "id": "b5ba3", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 76, + "x": 334.432541236889, + "y": 984.8935457196328, + "zIndex": 32814 + }, "b5e4d": { "drawAs": "rect", "fill": "#ffffff", @@ -2250,8 +2222,11 @@ "CompactIdentifier:hmdb:HMDB0000208", "alpha-ketoglutarate", "ChEBI:30915", - "ChEBI:30915", - "InChI:KPGXRSRHYNQIFN-UHFFFAOYSA-N" + "InChI:KPGXRSRHYNQIFN-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2298,7 +2273,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b62", - "isPartOf": "adca6", + "isPartOf": "c8125", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2356,7 +2331,6 @@ 0 ] }, - "id": "b7b8b", "isAttachedTo": "a4c55", "orientation": [ 0, @@ -2376,7 +2350,6 @@ 1 ] }, - "id": "cca7a", "isAttachedTo": "a5eda", "orientation": [ 0, @@ -2434,7 +2407,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b75", - "isPartOf": "f1253", + "isPartOf": "e6594", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2495,8 +2468,11 @@ "6-Phosphogluconate", "Wikidata:Q245501", "ChEBI:48928", - "ChEBI:48928", - "InChI:BIRSGZKFKXLSJQ-SQOUGZDYSA-N" + "InChI:BIRSGZKFKXLSJQ-SQOUGZDYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2508,36 +2484,6 @@ "y": 28.906414300736074, "zIndex": 32874 }, - "b9776": { - "contains": [ - "e62", - "b1e", - "c32" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 76.00000000000045, - "id": "b9776", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 76, - "x": 425.0052704413316, - "y": 987.2429475511315, - "zIndex": 32818 - }, "ba26e": { "backpageHead": "MDH1 (mt)", "drawAs": "rect", @@ -2609,8 +2555,12 @@ "Sedoheptulose-7-phosphate", "Wikidata:Q3040325", "ChEBI:15721", - "ChEBI:15721", - "InChI:JDTUMPKOJBQPKX-GBNDHIKLSA-N" + "InChI:JDTUMPKOJBQPKX-GBNDHIKLSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2632,7 +2582,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "ba9f4", - "isPartOf": "ae9da", + "isPartOf": "c8df5", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2674,7 +2624,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "badff", - "isPartOf": "ae9da", + "isPartOf": "c8df5", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2757,7 +2707,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bc581", - "isPartOf": "e6dde", + "isPartOf": "cba5e", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2799,7 +2749,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bd62d", - "isPartOf": "d70ab", + "isPartOf": "cf0a3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2858,7 +2808,6 @@ 0.5 ] }, - "id": "a6f81", "isAttachedTo": "af0de", "orientation": [ -1, @@ -2878,7 +2827,6 @@ 1 ] }, - "id": "cc6e4", "isAttachedTo": "a4c55", "orientation": [ 0, @@ -2910,7 +2858,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "be9", - "isPartOf": "ad3b9", + "isPartOf": "d2abd", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2953,7 +2901,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bf867", - "isPartOf": "dd8aa", + "isPartOf": "b2b63", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3014,8 +2962,12 @@ "Acetyl-CoA", "Wikidata:Q715317", "ChEBI:15351", - "ChEBI:15351", - "InChI:ZSLZBFCDCINBPY-ZSJPKINUSA-N" + "InChI:ZSLZBFCDCINBPY-ZSJPKINUSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3056,8 +3008,9 @@ "Xylulose-5-phosphate", "Wikidata:Q37864045", "ChEBI:27354", - "ChEBI:27354", - "InChI:FNZLKVNUWIIPSJ-UHFFFAOYSA-N" + "InChI:FNZLKVNUWIIPSJ-UHFFFAOYSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3178,8 +3131,12 @@ "Acetate", "Wikidata:Q47512", "ChEBI:15366", - "ChEBI:15366", - "InChI:QTBSBXVTEAMEQO-UHFFFAOYSA-N" + "InChI:QTBSBXVTEAMEQO-UHFFFAOYSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3191,6 +3148,35 @@ "y": 1221.501001001001, "zIndex": 32930 }, + "c2d9f": { + "contains": [ + "c41", + "a5d" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "c2d9f", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 59.33333333333333, + "x": 13.5520225566009, + "y": 631.7553576579847, + "zIndex": 32816 + }, "c30de": { "drawAs": "rect", "fill": "#ffffff", @@ -3201,7 +3187,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c30de", - "isPartOf": "e6dde", + "isPartOf": "cba5e", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3244,7 +3230,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c32", - "isPartOf": "b9776", + "isPartOf": "db8db", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3276,36 +3262,6 @@ "y": 8, "zIndex": 32878 }, - "c3c21": { - "contains": [ - "e04", - "dad", - "c6b" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 76, - "id": "c3c21", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 76, - "x": 669.2660360895651, - "y": 949.5206222265043, - "zIndex": 32794 - }, "c3e48": { "attachmentDisplay": { "offset": [ @@ -3342,7 +3298,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c41", - "isPartOf": "de691", + "isPartOf": "c2d9f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3384,7 +3340,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c4bc5", - "isPartOf": "dd8aa", + "isPartOf": "b2b63", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3445,10 +3401,15 @@ "Acetaldehyde", "Wikidata:Q61457", "ChEBI:15343", - "ChEBI:15343", "InChI:IKHGUXGNUITLKF-UHFFFAOYSA-N", "InChI:WGYWEDJQQFKGID-ZTKYFMRJSA-O", - "InChI:MBSKDCPWFSMEFD-ZKVZURMCSA-O" + "InChI:MBSKDCPWFSMEFD-ZKVZURMCSA-O", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3488,13 +3449,17 @@ "CompactIdentifier:cas:4151-19-3", "Ribulose-5-phosphate", "Wikidata:Q418886", - "ChEBI:37455", - "ChEBI:17363", + "ChEBI:17666", "ChEBI:17363", "ChEBI:37455", - "ChEBI:17666", "ChEBI:17797", - "InChI:FNZLKVNUWIIPSJ-UHNVWZDZSA-N" + "InChI:FNZLKVNUWIIPSJ-UHNVWZDZSA-N", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3559,8 +3524,11 @@ "CompactIdentifier:hmdb:HMDB0000223", "Oxaloacetate", "ChEBI:30744", - "ChEBI:30744", - "InChI:KHPXUQMNIQBQEV-UHFFFAOYSA-N" + "InChI:KHPXUQMNIQBQEV-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3601,8 +3569,11 @@ "Phosphoenolpyruvate", "Wikidata:Q412139", "ChEBI:44897", - "ChEBI:44897", - "InChI:DTBNBXWJWCWCIK-UHFFFAOYSA-N" + "InChI:DTBNBXWJWCWCIK-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3643,10 +3614,15 @@ "Acetaldehyde", "Wikidata:Q61457", "ChEBI:15343", - "ChEBI:15343", "InChI:IKHGUXGNUITLKF-UHFFFAOYSA-N", "InChI:WGYWEDJQQFKGID-ZTKYFMRJSA-O", - "InChI:MBSKDCPWFSMEFD-ZKVZURMCSA-O" + "InChI:MBSKDCPWFSMEFD-ZKVZURMCSA-O", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3711,7 +3687,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c6b", - "isPartOf": "c3c21", + "isPartOf": "b35b3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3801,7 +3777,6 @@ "CompactIdentifier:wikidata:Q37525", "Glucose", "Wikidata:Q37525", - "ChEBI:17234", "ChEBI:17234" ], "verticalAlign": "middle", @@ -3820,7 +3795,7 @@ "gpmlElementName": "Interaction", "id": "c80b0", "isAttachedTo": [ - "dd8aa", + "b2b63", "aa5bd" ], "kaavioType": "Edge", @@ -3837,8 +3812,7 @@ 0.5 ] }, - "id": "a0afa", - "isAttachedTo": "dd8aa", + "isAttachedTo": "b2b63", "orientation": [ -1, 0 @@ -3858,7 +3832,6 @@ 0 ] }, - "id": "b2be0", "isAttachedTo": "a9fe8", "orientation": [], "x": 1189.5259256513004, @@ -3873,6 +3846,35 @@ ], "zIndex": 32946 }, + "c8125": { + "contains": [ + "b44", + "b62" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "c8125", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 56, + "x": 670.5699263932703, + "y": 637.6151419558356, + "zIndex": 32790 + }, "c82f6": { "drawAs": "rect", "fill": "#ffffff", @@ -3883,7 +3885,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c82f6", - "isPartOf": "d447d", + "isPartOf": "fb169", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3903,8 +3905,11 @@ "Dihydroxyacetone", "Wikidata:Q409618", "ChEBI:16016", - "ChEBI:16016", - "InChI:RXKJFZQQPQGTFL-UHFFFAOYSA-N" + "InChI:RXKJFZQQPQGTFL-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3966,6 +3971,36 @@ "y": 1874.8203246434132, "zIndex": 33064 }, + "c8df5": { + "contains": [ + "badff", + "f0985", + "ba9f4" + ], + "drawAs": "rect", + "fill": "#b4b464", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 77.99999999999955, + "id": "c8df5", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 1, + "textAlign": "center", + "type": [ + "Group", + "GroupNone" + ], + "verticalAlign": "middle", + "width": 61.33333333333326, + "x": 1027.3449116758563, + "y": 2031.155928662868, + "zIndex": 33034 + }, "c95": { "backpageHead": "ENO2 | Enolase II catalyzes the first common ...", "drawAs": "rect", @@ -3977,7 +4012,7 @@ "gpmlElementName": "DataNode", "height": 19.999999999999982, "id": "c95", - "isPartOf": "adacc", + "isPartOf": "ad7e2", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4015,7 +4050,7 @@ "gpmlElementName": "Interaction", "id": "c9a68", "isAttachedTo": [ - "b45f0", + "a547f", "e91ac" ], "kaavioType": "Edge", @@ -4032,13 +4067,12 @@ 0.5 ] }, - "id": "cda42", - "isAttachedTo": "b45f0", + "isAttachedTo": "a547f", "orientation": [ 1, 0 ], - "x": 610.2363677956936, + "x": 610.2363677956935, "y": 1941.537827566498 }, { @@ -4053,7 +4087,6 @@ 0 ] }, - "id": "bba6e", "isAttachedTo": "d8535", "orientation": [], "x": 635.7692588535956, @@ -4086,7 +4119,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c9b82", - "isPartOf": "ad054", + "isPartOf": "dc1a8", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4245,7 +4278,6 @@ 0.5 ] }, - "id": "edce8", "isAttachedTo": "c5ba3", "orientation": [ 1, @@ -4265,7 +4297,6 @@ 0.5 ] }, - "id": "b1225", "isAttachedTo": "d12ff", "orientation": [ 1, @@ -4275,17 +4306,76 @@ "y": 1709.586223682608 } ], - "stroke": "#000000", + "stroke": "#000000", + "strokeWidth": 1, + "type": [ + "Interaction", + "Edge", + "SBO:0000167", + "SBO:0000393", + "SBO:0000394", + "DirectedInteraction" + ], + "zIndex": 32980 + }, + "cb175": { + "contains": [ + "a26", + "e96" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "cb175", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 96, + "x": 1088.8560539148768, + "y": 1063.0021251197722, + "zIndex": 32858 + }, + "cba5e": { + "contains": [ + "f924c", + "c30de", + "bc581" + ], + "drawAs": "rect", + "fill": "#b4b464", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 78, + "id": "cba5e", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", "strokeWidth": 1, + "textAlign": "center", "type": [ - "Interaction", - "Edge", - "SBO:0000167", - "SBO:0000393", - "SBO:0000394", - "DirectedInteraction" + "Group", + "GroupNone" ], - "zIndex": 32980 + "verticalAlign": "middle", + "width": 58, + "x": 1062.2498478763532, + "y": 1573.0360228793952, + "zIndex": 32994 }, "cc0ba": { "drawAs": "StraightLine", @@ -4293,7 +4383,7 @@ "gpmlElementName": "Interaction", "id": "cc0ba", "isAttachedTo": [ - "ad054", + "dc1a8", "bd6b6" ], "kaavioType": "Edge", @@ -4310,8 +4400,7 @@ 0 ] }, - "id": "e87f2", - "isAttachedTo": "ad054", + "isAttachedTo": "dc1a8", "orientation": [ 0, -1 @@ -4331,7 +4420,6 @@ 0 ] }, - "id": "eb062", "isAttachedTo": "e2ab2", "orientation": [], "x": 759.4318313843643, @@ -4357,7 +4445,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "cd8", - "isPartOf": "d57c0", + "isPartOf": "abda6", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4417,8 +4505,11 @@ "CompactIdentifier:hmdb:HMDB0000223", "Oxaloacetate", "ChEBI:30744", - "ChEBI:30744", - "InChI:KHPXUQMNIQBQEV-UHFFFAOYSA-N" + "InChI:KHPXUQMNIQBQEV-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4459,8 +4550,11 @@ "3-Phosphoglycerate", "Wikidata:Q32904835", "ChEBI:17050", - "ChEBI:17050", - "InChI:OSJPPGNTCRNQQC-UHFFFAOYSA-N" + "InChI:OSJPPGNTCRNQQC-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4483,7 +4577,7 @@ "gpmlElementName": "DataNode", "height": 19.999999999999982, "id": "cdf", - "isPartOf": "d7c34", + "isPartOf": "ff97e", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4600,7 +4694,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "cf015", - "isPartOf": "b45f0", + "isPartOf": "a547f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4632,6 +4726,37 @@ "y": 29, "zIndex": 33008 }, + "cf0a3": { + "contains": [ + "efca8", + "bd62d", + "fb10b", + "fcb06" + ], + "drawAs": "rect", + "fill": "#b4b464", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 98, + "id": "cf0a3", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 1, + "textAlign": "center", + "type": [ + "Group", + "GroupNone" + ], + "verticalAlign": "middle", + "width": 58, + "x": 1204.2980406474376, + "y": 1865.459048314469, + "zIndex": 33010 + }, "cfe": { "backpageHead": "MDH3 (cyto)", "drawAs": "rect", @@ -4643,7 +4768,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "cfe", - "isPartOf": "d57c0", + "isPartOf": "abda6", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4703,10 +4828,13 @@ "CompactIdentifier:cas:643-13-0", "Fructose-6-phosphate", "Wikidata:Q32039197", - "ChEBI:61553", - "ChEBI:15946", "ChEBI:15946", - "InChI:GSXOAOHZAIYLCY-HSUXUTPPSA-N" + "ChEBI:61553", + "InChI:GSXOAOHZAIYLCY-HSUXUTPPSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4728,7 +4856,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "d08", - "isPartOf": "d83b4", + "isPartOf": "f6127", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4831,8 +4959,9 @@ "Citrate", "Wikidata:Q55503059", "ChEBI:16947", - "ChEBI:16947", - "InChI:KRKNYBCHXYNGOX-UHFFFAOYSA-K" + "InChI:KRKNYBCHXYNGOX-UHFFFAOYSA-K", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4892,7 +5021,7 @@ "gpmlElementName": "Interaction", "id": "d1da3", "isAttachedTo": [ - "ae9da", + "c8df5", "f81b5" ], "kaavioType": "Edge", @@ -4909,14 +5038,13 @@ 0 ] }, - "id": "b3fe9", - "isAttachedTo": "ae9da", + "isAttachedTo": "c8df5", "orientation": [ 0, -1 ], "x": 1058.011578342523, - "y": 2032.155928662868 + "y": 2032.1559286628683 }, { "attachmentDisplay": { @@ -4930,7 +5058,6 @@ 0 ] }, - "id": "d3157", "isAttachedTo": "dfcf3", "orientation": [], "x": 1045.2182548375313, @@ -4972,7 +5099,6 @@ 0.5 ] }, - "id": "c653e", "isAttachedTo": "a9d1a", "orientation": [ -1, @@ -4992,7 +5118,6 @@ 0.5 ] }, - "id": "a5feb", "isAttachedTo": "af0de", "orientation": [ -1, @@ -5014,10 +5139,10 @@ ], "zIndex": 32972 }, - "d297c": { + "d2abd": { "contains": [ - "a25", - "a00" + "be9", + "e67" ], "drawAs": "none", "fill": "transparent", @@ -5026,7 +5151,7 @@ "fontWeight": "bold", "gpmlElementName": "Group", "height": 56, - "id": "d297c", + "id": "d2abd", "kaavioType": "Group", "padding": 8, "stroke": "#808080", @@ -5038,10 +5163,39 @@ "GroupGroup" ], "verticalAlign": "middle", - "width": 56, - "x": 695.1335436382752, - "y": 330.2544689800214, - "zIndex": 32864 + "width": 59.33333333333337, + "x": 754.4709687742878, + "y": 68.38336281249433, + "zIndex": 32786 + }, + "d302f": { + "contains": [ + "b0c", + "e28" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "d302f", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 76, + "x": 201.30599369085172, + "y": 286.38485804416405, + "zIndex": 32776 }, "d33f4": { "drawAs": "rect", @@ -5071,8 +5225,10 @@ "CompactIdentifier:hmdb:HMDB0000243", "Pyruvate", "ChEBI:32816", - "ChEBI:32816", - "InChI:LCTONWCANYUPML-UHFFFAOYSA-N" + "InChI:LCTONWCANYUPML-UHFFFAOYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5109,35 +5265,6 @@ "width": 0, "zIndex": 12288 }, - "d447d": { - "contains": [ - "dab", - "c82f6" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 55.310725552051, - "id": "d447d", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 111.73080967402734, - "x": 58.24605678233439, - "y": 464.649842271293, - "zIndex": 32840 - }, "d46": { "backpageHead": "GPM1 | Tetrameric phosphoglycerate mutase med...", "drawAs": "rect", @@ -5180,35 +5307,6 @@ "y": 753.3333333333333, "zIndex": 32832 }, - "d57c0": { - "contains": [ - "cfe", - "cd8" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "d57c0", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 76, - "x": 103.6581799190497, - "y": 1290.591961526744, - "zIndex": 32810 - }, "d60": { "drawAs": "none", "fill": "transparent", @@ -5270,6 +5368,38 @@ "y": 144.66461628588195, "zIndex": -3 }, + "d678d": { + "contains": [ + "b1a2a", + "a7146", + "fc4c0", + "b2546", + "fc09e" + ], + "drawAs": "Octagon", + "fill": "#b4b464", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 124, + "id": "d678d", + "kaavioType": "Group", + "padding": 11, + "stroke": "#808080", + "strokeWidth": 1, + "textAlign": "center", + "type": [ + "Group", + "Complex", + "GroupComplex" + ], + "verticalAlign": "middle", + "width": 90.66666666666663, + "x": 836.492917820675, + "y": 1466.096442903443, + "zIndex": 32998 + }, "d6ab3": { "drawAs": "StraightLine", "fill": "none", @@ -5293,7 +5423,6 @@ 0.5 ] }, - "id": "bf293", "isAttachedTo": "d1910", "orientation": [ 1, @@ -5314,7 +5443,6 @@ 0 ] }, - "id": "e722a", "isAttachedTo": "ca637", "orientation": [], "x": 700.9230894626565, @@ -5399,8 +5527,11 @@ "CompactIdentifier:hmdb:HMDB0000134", "Fumarate", "ChEBI:18012", - "ChEBI:18012", - "InChI:VZCYOOQTPOCHFL-OWOJBTEDSA-N" + "InChI:VZCYOOQTPOCHFL-OWOJBTEDSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5412,37 +5543,6 @@ "y": 1829.438967993184, "zIndex": 33004 }, - "d70ab": { - "contains": [ - "efca8", - "bd62d", - "fb10b", - "fcb06" - ], - "drawAs": "rect", - "fill": "#b4b464", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 98, - "id": "d70ab", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 1, - "textAlign": "center", - "type": [ - "Group", - "GroupNone" - ], - "verticalAlign": "middle", - "width": 58, - "x": 1204.2980406474376, - "y": 1865.459048314469, - "zIndex": 33010 - }, "d72fa": { "attachmentDisplay": { "offset": [ @@ -5510,36 +5610,6 @@ "y": 433.84858044164014, "zIndex": 32802 }, - "d7c34": { - "contains": [ - "f65", - "b17", - "cdf" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 76, - "id": "d7c34", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 91.93059936908588, - "x": 266.21974503479413, - "y": 518.3210812982194, - "zIndex": 32850 - }, "d7f": { "drawAs": "rect", "fill": "#ffffff", @@ -5581,35 +5651,34 @@ "y": 111.91868970877326, "zIndex": 32868 }, - "d83b4": { + "d814c": { "contains": [ - "d08", - "db6", - "ac9" + "b29ed", + "b511b" ], - "drawAs": "none", - "fill": "transparent", + "drawAs": "rect", + "fill": "#b4b464", "fillOpacity": 0.1, "fontSize": 1, "fontWeight": "bold", "gpmlElementName": "Group", - "height": 76.00000000000001, - "id": "d83b4", + "height": 58, + "id": "d814c", "kaavioType": "Group", "padding": 8, "stroke": "#808080", "strokeDasharray": "5,3", - "strokeWidth": 0, + "strokeWidth": 1, "textAlign": "center", "type": [ "Group", - "GroupGroup" + "GroupNone" ], "verticalAlign": "middle", - "width": 76, - "x": 229.46216796964268, - "y": 62.47021441960406, - "zIndex": 32798 + "width": 58, + "x": 725.4832032387318, + "y": 2034.92001454225, + "zIndex": 33020 }, "d8535": { "attachmentDisplay": { @@ -5693,7 +5762,6 @@ 0 ] }, - "id": "dbf5a", "isAttachedTo": "d6f0e", "orientation": [ 0, @@ -5713,7 +5781,6 @@ 1 ] }, - "id": "f44e7", "isAttachedTo": "a4c55", "orientation": [ 0, @@ -5745,7 +5812,7 @@ "gpmlElementName": "DataNode", "height": 19, "id": "dab", - "isPartOf": "d447d", + "isPartOf": "fb169", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5766,10 +5833,14 @@ "Wikidata:Q177811", "ChEBI:26078", "ChEBI:18367", - "ChEBI:26078", - "ChEBI:18367", "InChI:NBIIXXVUZAFLBC-UHFFFAOYSA-K", - "InChI:NBIIXXVUZAFLBC-UHFFFAOYSA-N" + "InChI:NBIIXXVUZAFLBC-UHFFFAOYSA-N", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5792,7 +5863,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "dad", - "isPartOf": "c3c21", + "isPartOf": "b35b3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5835,7 +5906,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "db6", - "isPartOf": "d83b4", + "isPartOf": "f6127", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5867,6 +5938,36 @@ "y": 8, "zIndex": 32844 }, + "db8db": { + "contains": [ + "e62", + "b1e", + "c32" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 76.00000000000045, + "id": "db8db", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 76, + "x": 425.0052704413316, + "y": 987.2429475511315, + "zIndex": 32818 + }, "dc1": { "drawAs": "none", "fill": "transparent", @@ -5923,6 +6024,35 @@ "width": 0, "zIndex": 12288 }, + "dc1a8": { + "contains": [ + "b0a13", + "c9b82" + ], + "drawAs": "Octagon", + "fill": "#b4b464", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 64, + "id": "dc1a8", + "kaavioType": "Group", + "padding": 11, + "stroke": "#808080", + "strokeWidth": 1, + "textAlign": "center", + "type": [ + "Group", + "Complex", + "GroupComplex" + ], + "verticalAlign": "middle", + "width": 94.1807228915668, + "x": 695.4887274452622, + "y": 1791.2891366001006, + "zIndex": 33056 + }, "dc92a": { "drawAs": "rect", "fill": "#ffffff", @@ -5974,7 +6104,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "dd1df", - "isPartOf": "b45f0", + "isPartOf": "a547f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6006,35 +6136,6 @@ "y": 49, "zIndex": 33006 }, - "dd8aa": { - "contains": [ - "bf867", - "c4bc5" - ], - "drawAs": "rect", - "fill": "#b4b464", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 58, - "id": "dd8aa", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 1, - "textAlign": "center", - "type": [ - "Group", - "GroupNone" - ], - "verticalAlign": "middle", - "width": 61.33333333333326, - "x": 1226.0182548375315, - "y": 1721.9115248874275, - "zIndex": 33044 - }, "de48f": { "drawAs": "rect", "fill": "#ffffff", @@ -6064,8 +6165,10 @@ "2-Phosphoglycerate", "Wikidata:Q209469", "ChEBI:24344", - "ChEBI:24344", - "InChI:GXIURPTVHJPJLF-UHFFFAOYSA-N" + "InChI:GXIURPTVHJPJLF-UHFFFAOYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6077,35 +6180,6 @@ "y": 801.7770767613044, "zIndex": 32768 }, - "de691": { - "contains": [ - "c41", - "a5d" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "de691", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 59.33333333333333, - "x": 13.5520225566009, - "y": 631.7553576579847, - "zIndex": 32816 - }, "deaf8": { "attachmentDisplay": { "offset": [ @@ -6162,11 +6236,15 @@ "Wikidata:Q28529691", "ChEBI:28013", "ChEBI:16905", - "ChEBI:28013", - "ChEBI:16905", "ChEBI:37736", "InChI:RNBGYGVWRKECFJ-ARQDHWQXSA-N", - "InChI:XPYBSIWDXQFNMH-UYFOZJQFSA-N" + "InChI:XPYBSIWDXQFNMH-UYFOZJQFSA-N", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6238,7 +6316,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "dfb", - "isPartOf": "a700a", + "isPartOf": "b1633", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6324,8 +6402,11 @@ "Glyceraldehyde-3-phosphate", "Wikidata:Q794810", "ChEBI:17138", - "ChEBI:17138", - "InChI:LXJXRIRHZLFYRP-UHFFFAOYSA-N" + "InChI:LXJXRIRHZLFYRP-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6348,7 +6429,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e04", - "isPartOf": "c3c21", + "isPartOf": "b35b3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6409,8 +6490,11 @@ "Glucose-6-phosphate", "Wikidata:Q418865", "ChEBI:29042", - "ChEBI:29042", - "InChI:HXXFSFRBOHSIMQ-VFUOTHLCSA-N" + "InChI:HXXFSFRBOHSIMQ-VFUOTHLCSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6475,8 +6559,11 @@ "CompactIdentifier:hmdb:HMDB0000254", "Succinate", "ChEBI:15741", - "ChEBI:15741", - "InChI:KDYFGRWQOYBRFD-UHFFFAOYSA-N" + "InChI:KDYFGRWQOYBRFD-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6494,7 +6581,7 @@ "gpmlElementName": "Interaction", "id": "e21ce", "isAttachedTo": [ - "fff2a", + "d814c", "f1741" ], "kaavioType": "Edge", @@ -6511,8 +6598,7 @@ 0 ] }, - "id": "cc9ba", - "isAttachedTo": "fff2a", + "isAttachedTo": "d814c", "orientation": [ 0, -1 @@ -6532,7 +6618,6 @@ 0 ] }, - "id": "c5a6e", "isAttachedTo": "ca68e", "orientation": [], "x": 767.704520742355, @@ -6583,7 +6668,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e28", - "isPartOf": "ebe17", + "isPartOf": "d302f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6669,8 +6754,11 @@ "D-6-Phospho-glucono-delta-lactone", "Wikidata:Q114174", "ChEBI:16217", - "ChEBI:16217", - "InChI:PHOQVHQSTUBQQK-SQOUGZDYSA-N" + "InChI:PHOQVHQSTUBQQK-SQOUGZDYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6692,7 +6780,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e3a32", - "isPartOf": "b45f0", + "isPartOf": "a547f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6776,7 +6864,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e4a", - "isPartOf": "efab8", + "isPartOf": "f63a0", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6839,7 +6927,7 @@ "gpmlElementName": "Interaction", "id": "e5514", "isAttachedTo": [ - "e6dde", + "cba5e", "cac51" ], "kaavioType": "Edge", @@ -6856,8 +6944,7 @@ 1 ] }, - "id": "ce61e", - "isAttachedTo": "e6dde", + "isAttachedTo": "cba5e", "orientation": [ 0, 1 @@ -6877,7 +6964,6 @@ 0 ] }, - "id": "be562", "isAttachedTo": "c3e48", "orientation": [], "x": 1040.8653100536683, @@ -6928,7 +7014,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e62", - "isPartOf": "b9776", + "isPartOf": "db8db", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6984,7 +7070,6 @@ 0 ] }, - "id": "b3001", "isAttachedTo": "c57ae", "orientation": [], "x": 1017.6147771627888, @@ -7001,7 +7086,6 @@ 0 ] }, - "id": "c3bba", "isAttachedTo": "e1d0a", "orientation": [ 0, @@ -7033,7 +7117,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e64", - "isPartOf": "a700a", + "isPartOf": "b1633", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7065,6 +7149,35 @@ "y": 8, "zIndex": 32870 }, + "e6594": { + "contains": [ + "ed0", + "b75" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "e6594", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 76, + "x": 271.107694651173, + "y": 1155.8852983418194, + "zIndex": 32800 + }, "e67": { "drawAs": "rect", "fill": "#ffffff", @@ -7075,7 +7188,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e67", - "isPartOf": "ad3b9", + "isPartOf": "d2abd", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7129,7 +7242,6 @@ 1 ] }, - "id": "d4999", "isAttachedTo": "b50a0", "orientation": [ 0, @@ -7150,7 +7262,6 @@ 0 ] }, - "id": "dd2c5", "isAttachedTo": "ce270", "orientation": [], "x": 999.1357642515505, @@ -7165,36 +7276,6 @@ ], "zIndex": 32944 }, - "e6dde": { - "contains": [ - "f924c", - "c30de", - "bc581" - ], - "drawAs": "rect", - "fill": "#b4b464", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 78, - "id": "e6dde", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 1, - "textAlign": "center", - "type": [ - "Group", - "GroupNone" - ], - "verticalAlign": "middle", - "width": 58, - "x": 1062.2498478763532, - "y": 1573.0360228793952, - "zIndex": 32994 - }, "e7272": { "drawAs": "rect", "fill": "#ffffff", @@ -7205,7 +7286,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e7272", - "isPartOf": "b45f0", + "isPartOf": "a547f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7266,8 +7347,9 @@ "Xylulose-5-phosphate", "Wikidata:Q37864045", "ChEBI:27354", - "ChEBI:27354", - "InChI:FNZLKVNUWIIPSJ-UHFFFAOYSA-N" + "InChI:FNZLKVNUWIIPSJ-UHFFFAOYSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7460,7 +7542,6 @@ 0 ] }, - "id": "f3876", "isAttachedTo": "e1d0a", "orientation": [ 0, @@ -7480,7 +7561,6 @@ 1 ] }, - "id": "b0110", "isAttachedTo": "d6f0e", "orientation": [ 0, @@ -7502,31 +7582,6 @@ ], "zIndex": 32956 }, - "e9333": { - "attachmentDisplay": { - "offset": [ - 0, - 0 - ], - "position": [ - 0.525128448991357, - 0 - ] - }, - "drawAs": "none", - "gpmlElementName": "Anchor", - "height": 0, - "id": "e9333", - "isAttachedTo": "id8f21573e", - "kaavioType": "Burr", - "strokeWidth": 0, - "type": [ - "Anchor", - "Burr" - ], - "width": 0, - "zIndex": 12288 - }, "e96": { "backpageHead": "ADH3 (mt)", "drawAs": "rect", @@ -7538,7 +7593,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e96", - "isPartOf": "affe3", + "isPartOf": "cb175", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7715,47 +7770,21 @@ "Ethanol", "Wikidata:Q153", "ChEBI:16236", - "ChEBI:16236", - "InChI:LFQSCWFLJHTTHZ-UHFFFAOYSA-N" - ], - "verticalAlign": "middle", - "whiteSpace": "pre", - "width": 64.33333333333333, - "wpType": "Metabolite", - "x": 783.5593047034764, - "xrefDataSource": "CAS", - "xrefIdentifier": "64-17-5", - "y": 1023.8333333333333, - "zIndex": 32894 - }, - "ebe17": { - "contains": [ - "b0c", - "e28" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "ebe17", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" + "InChI:LFQSCWFLJHTTHZ-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", - "width": 76, - "x": 201.30599369085172, - "y": 286.38485804416405, - "zIndex": 32776 + "whiteSpace": "pre", + "width": 64.33333333333333, + "wpType": "Metabolite", + "x": 783.5593047034764, + "xrefDataSource": "CAS", + "xrefIdentifier": "64-17-5", + "y": 1023.8333333333333, + "zIndex": 32894 }, "ebf": { "backpageHead": "ACS1 (mt)", @@ -7810,7 +7839,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "ed0", - "isPartOf": "f1253", + "isPartOf": "e6594", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7853,7 +7882,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "ed5", - "isPartOf": "adacc", + "isPartOf": "ad7e2", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7945,8 +7974,12 @@ "Acetate", "Wikidata:Q47512", "ChEBI:15366", - "ChEBI:15366", - "InChI:QTBSBXVTEAMEQO-UHFFFAOYSA-N" + "InChI:QTBSBXVTEAMEQO-UHFFFAOYSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7983,35 +8016,6 @@ "width": 0, "zIndex": 12288 }, - "efab8": { - "contains": [ - "e4a", - "a90" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 55.999999999999986, - "id": "efab8", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 56, - "x": 524.3726740730593, - "y": 13.014492753623216, - "zIndex": 32806 - }, "efca8": { "drawAs": "rect", "fill": "#ffffff", @@ -8022,7 +8026,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "efca8", - "isPartOf": "d70ab", + "isPartOf": "cf0a3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8077,7 +8081,6 @@ 0.5 ] }, - "id": "c9d9b", "isAttachedTo": "ba26e", "orientation": [ -1, @@ -8098,7 +8101,6 @@ 0 ] }, - "id": "e234a", "isAttachedTo": "d72fa", "orientation": [], "x": 737.392618960691, @@ -8139,7 +8141,6 @@ 1 ] }, - "id": "b70e7", "isAttachedTo": "a5eda", "orientation": [ 0, @@ -8159,7 +8160,6 @@ 0 ] }, - "id": "da654", "isAttachedTo": "b50a0", "orientation": [ 0, @@ -8207,7 +8207,6 @@ 1 ] }, - "id": "cb041", "isAttachedTo": "a9d1a", "orientation": [ 0, @@ -8227,7 +8226,6 @@ 0 ] }, - "id": "ec920", "isAttachedTo": "b5e4d", "orientation": [ 0, @@ -8259,7 +8257,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f0985", - "isPartOf": "ae9da", + "isPartOf": "c8df5", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8291,35 +8289,6 @@ "y": 29, "zIndex": 33058 }, - "f1253": { - "contains": [ - "ed0", - "b75" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "f1253", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 76, - "x": 271.107694651173, - "y": 1155.8852983418194, - "zIndex": 32800 - }, "f12ba": { "attachmentDisplay": { "offset": [ @@ -8426,7 +8395,6 @@ 0.5 ] }, - "id": "d0872", "isAttachedTo": "a04a4", "orientation": [ -1, @@ -8446,7 +8414,6 @@ 1 ] }, - "id": "e86fe", "isAttachedTo": "e1d0a", "orientation": [ 0, @@ -8541,7 +8508,6 @@ 0 ] }, - "id": "a8be8", "isAttachedTo": "c8b2e", "orientation": [ 0, @@ -8562,7 +8528,6 @@ 0 ] }, - "id": "fd28b", "isAttachedTo": "c9ffa", "orientation": [], "x": 1080.5568819197006, @@ -8625,7 +8590,7 @@ "gpmlElementName": "Interaction", "id": "f50e7", "isAttachedTo": [ - "aa47f", + "d678d", "efdc6" ], "kaavioType": "Edge", @@ -8642,13 +8607,12 @@ 0 ] }, - "id": "d110f", - "isAttachedTo": "aa47f", + "isAttachedTo": "d678d", "orientation": [ 0, -1 ], - "x": 859.1595844873416, + "x": 859.1595844873417, "y": 1466.096442903443 }, { @@ -8663,7 +8627,6 @@ 0 ] }, - "id": "b5350", "isAttachedTo": "a169d", "orientation": [], "x": 848.121498171803, @@ -8733,6 +8696,65 @@ "width": 0, "zIndex": 12288 }, + "f6127": { + "contains": [ + "d08", + "db6", + "ac9" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 76.00000000000001, + "id": "f6127", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 76, + "x": 229.46216796964268, + "y": 62.47021441960406, + "zIndex": 32798 + }, + "f63a0": { + "contains": [ + "e4a", + "a90" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 55.999999999999986, + "id": "f63a0", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 56, + "x": 524.3726740730593, + "y": 13.014492753623216, + "zIndex": 32806 + }, "f65": { "backpageHead": "TDH1", "drawAs": "rect", @@ -8744,7 +8766,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f65", - "isPartOf": "d7c34", + "isPartOf": "ff97e", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8858,7 +8880,6 @@ 1 ] }, - "id": "df54c", "isAttachedTo": "b5e4d", "orientation": [ 0, @@ -8878,7 +8899,6 @@ 0.5 ] }, - "id": "ababa", "isAttachedTo": "a04a4", "orientation": [ -1, @@ -8931,7 +8951,7 @@ "gpmlElementName": "Interaction", "id": "f89ef", "isAttachedTo": [ - "d70ab", + "cf0a3", "f0873" ], "kaavioType": "Edge", @@ -8948,8 +8968,7 @@ 0.5 ] }, - "id": "b57be", - "isAttachedTo": "d70ab", + "isAttachedTo": "cf0a3", "orientation": [ -1, 0 @@ -8969,7 +8988,6 @@ 0 ] }, - "id": "eab0f", "isAttachedTo": "e7328", "orientation": [], "x": 1182.029438813944, @@ -9036,7 +9054,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f924c", - "isPartOf": "e6dde", + "isPartOf": "cba5e", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9095,7 +9113,7 @@ }, "fa647": { "cellularComponent": "Organelle", - "drawAs": "rect", + "drawAs": "Ellipse", "fill": "transparent", "fontFamily": "Arial", "fontSize": 10, @@ -9109,8 +9127,6 @@ "overflow": "hidden", "padding": 8, "rotation": 293.3886584209786, - "rx": 15, - "ry": 15, "stroke": "#c0c0c0", "strokeStyle": "double", "strokeWidth": 3, @@ -9159,7 +9175,6 @@ 0 ] }, - "id": "f3cda", "isAttachedTo": "a4c55", "orientation": [ 0, @@ -9179,7 +9194,6 @@ 0.5 ] }, - "id": "a0624", "isAttachedTo": "c5ba3", "orientation": [ 1, @@ -9211,7 +9225,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "fb10b", - "isPartOf": "d70ab", + "isPartOf": "cf0a3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9243,6 +9257,35 @@ "y": 69, "zIndex": 33040 }, + "fb169": { + "contains": [ + "dab", + "c82f6" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 55.310725552051, + "id": "fb169", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 111.73080967402734, + "x": 58.24605678233439, + "y": 464.649842271293, + "zIndex": 32840 + }, "fb2": { "drawAs": "rect", "fill": "#ffffff", @@ -9271,10 +9314,13 @@ "CompactIdentifier:cas:643-13-0", "Fructose-6-phosphate", "Wikidata:Q32039197", - "ChEBI:61553", - "ChEBI:15946", "ChEBI:15946", - "InChI:GSXOAOHZAIYLCY-HSUXUTPPSA-N" + "ChEBI:61553", + "InChI:GSXOAOHZAIYLCY-HSUXUTPPSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9338,7 +9384,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "fc09e", - "isPartOf": "aa47f", + "isPartOf": "d678d", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9381,7 +9427,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "fc4c0", - "isPartOf": "aa47f", + "isPartOf": "d678d", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9424,7 +9470,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "fc7", - "isPartOf": "b022f", + "isPartOf": "b5ba3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9484,12 +9530,17 @@ "CompactIdentifier:cas:57-03-4", "Glycerol 3-phosphate", "Wikidata:Q2739882", - "ChEBI:15978", - "ChEBI:14336", "ChEBI:14336", "ChEBI:15978", "InChI:AWUCVROLDVIAJX-UHFFFAOYSA-N", - "InChI:AWUCVROLDVIAJX-GSVOUGTGSA-N" + "InChI:AWUCVROLDVIAJX-GSVOUGTGSA-N", + "", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9511,7 +9562,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "fcb06", - "isPartOf": "d70ab", + "isPartOf": "cf0a3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9660,34 +9711,35 @@ "width": 0, "zIndex": 12288 }, - "fff2a": { + "ff97e": { "contains": [ - "b29ed", - "b511b" + "f65", + "b17", + "cdf" ], - "drawAs": "rect", - "fill": "#b4b464", + "drawAs": "none", + "fill": "transparent", "fillOpacity": 0.1, "fontSize": 1, "fontWeight": "bold", "gpmlElementName": "Group", - "height": 58, - "id": "fff2a", + "height": 76, + "id": "ff97e", "kaavioType": "Group", "padding": 8, "stroke": "#808080", "strokeDasharray": "5,3", - "strokeWidth": 1, + "strokeWidth": 0, "textAlign": "center", "type": [ "Group", - "GroupNone" + "GroupGroup" ], "verticalAlign": "middle", - "width": 58, - "x": 725.4832032387318, - "y": 2034.92001454225, - "zIndex": 33020 + "width": 91.93059936908588, + "x": 266.21974503479413, + "y": 518.3210812982194, + "zIndex": 32850 }, "http://identifiers.org/pw/PW:0000469": { "gpmlElementName": "openControlledVocabulary", @@ -9725,7 +9777,6 @@ 1 ] }, - "id": "fcd9a", "isAttachedTo": "c7c", "orientation": [ 0, @@ -9745,7 +9796,6 @@ 0 ] }, - "id": "aee31", "isAttachedTo": "e10", "orientation": [ 0, @@ -9793,7 +9843,6 @@ 0 ] }, - "id": "ae997", "isAttachedTo": "fb2", "orientation": [ 0, @@ -9813,7 +9862,6 @@ 1 ] }, - "id": "fa25f", "isAttachedTo": "e10", "orientation": [ 0, @@ -9841,7 +9889,7 @@ "gpmlElementName": "Interaction", "id": "id14b678d", "isAttachedTo": [ - "c3c21", + "b35b3", "idc5076c10" ], "kaavioType": "Edge", @@ -9858,8 +9906,7 @@ 1 ] }, - "id": "cc5db", - "isAttachedTo": "c3c21", + "isAttachedTo": "b35b3", "orientation": [ 0, 1 @@ -9879,7 +9926,6 @@ 0 ] }, - "id": "da2ab", "isAttachedTo": "f2f81", "orientation": [], "x": 702.2237218813907, @@ -9920,7 +9966,6 @@ 1 ] }, - "id": "d9186", "isAttachedTo": "fb2", "orientation": [ 0, @@ -9930,12 +9975,10 @@ "y": 259.5 }, { - "id": "dd223", "x": 240.79915878023135, "y": 293.3753943217666 }, { - "id": "d9d9e", "x": 240.79915878023135, "y": 334.38485804416405 }, @@ -9950,7 +9993,6 @@ 0 ] }, - "id": "dc30c", "isAttachedTo": "decde", "orientation": [ 0, @@ -9982,8 +10024,6 @@ "c5ba3" ], "kaavioType": "Edge", - "markerEnd": "Arrow", - "markerStart": "Arrow", "points": [ { "attachmentDisplay": { @@ -9996,7 +10036,6 @@ 0.5 ] }, - "id": "cd5a9", "isAttachedTo": "cd897", "orientation": [ 1, @@ -10016,7 +10055,6 @@ 0.5 ] }, - "id": "ac7d9", "isAttachedTo": "c5ba3", "orientation": [ 1, @@ -10031,11 +10069,7 @@ "strokeWidth": 1, "type": [ "Interaction", - "Edge", - "SBO:0000167", - "SBO:0000393", - "SBO:0000394", - "DirectedInteraction" + "Edge" ], "zIndex": 12320 }, @@ -10045,7 +10079,7 @@ "gpmlElementName": "Interaction", "id": "id15c6b788", "isAttachedTo": [ - "affe3", + "cb175", "id44769015" ], "kaavioType": "Edge", @@ -10062,8 +10096,7 @@ 0.5 ] }, - "id": "db4b9", - "isAttachedTo": "affe3", + "isAttachedTo": "cb175", "orientation": [ -1, 0 @@ -10083,7 +10116,6 @@ 0 ] }, - "id": "dcd20", "isAttachedTo": "df019", "orientation": [], "x": 1057.2, @@ -10108,8 +10140,6 @@ "a41" ], "kaavioType": "Edge", - "markerEnd": "Arrow", - "markerStart": "Arrow", "points": [ { "attachmentDisplay": { @@ -10122,7 +10152,6 @@ 0.5 ] }, - "id": "c9482", "isAttachedTo": "eb9", "orientation": [ 1, @@ -10142,7 +10171,6 @@ 0.5 ] }, - "id": "e2f9f", "isAttachedTo": "a41", "orientation": [ 1, @@ -10157,11 +10185,7 @@ "strokeWidth": 1, "type": [ "Interaction", - "Edge", - "SBO:0000167", - "SBO:0000393", - "SBO:0000394", - "DirectedInteraction" + "Edge" ], "zIndex": 12382 }, @@ -10171,7 +10195,7 @@ "gpmlElementName": "Interaction", "id": "id16bcd509", "isAttachedTo": [ - "d83b4", + "f6127", "id131ce191" ], "kaavioType": "Edge", @@ -10188,8 +10212,7 @@ 0.5 ] }, - "id": "c8407", - "isAttachedTo": "d83b4", + "isAttachedTo": "f6127", "orientation": [ 1, 0 @@ -10209,7 +10232,6 @@ 0 ] }, - "id": "ccb87", "isAttachedTo": "e4d0c", "orientation": [], "x": 320.91692954784435, @@ -10250,7 +10272,6 @@ 1 ] }, - "id": "dbfaa", "isAttachedTo": "e10", "orientation": [ 0, @@ -10270,7 +10291,6 @@ 0 ] }, - "id": "cafcb", "isAttachedTo": "fb2", "orientation": [ 0, @@ -10298,7 +10318,7 @@ "gpmlElementName": "Interaction", "id": "id1c04130b", "isAttachedTo": [ - "de691", + "c2d9f", "id9e922fe9" ], "kaavioType": "Edge", @@ -10315,8 +10335,7 @@ 0.5 ] }, - "id": "db264", - "isAttachedTo": "de691", + "isAttachedTo": "c2d9f", "orientation": [ 1, 0 @@ -10336,7 +10355,6 @@ 0 ] }, - "id": "a2e5c", "isAttachedTo": "df29a", "orientation": [], "x": 91.32463950899478, @@ -10357,7 +10375,7 @@ "gpmlElementName": "Interaction", "id": "id1c7bbf35", "isAttachedTo": [ - "b022f", + "b5ba3", "id5a27bca" ], "kaavioType": "Edge", @@ -10374,8 +10392,7 @@ 0.5 ] }, - "id": "e154a", - "isAttachedTo": "b022f", + "isAttachedTo": "b5ba3", "orientation": [ -1, 0 @@ -10395,7 +10412,6 @@ 0 ] }, - "id": "e84cb", "isAttachedTo": "ef131", "orientation": [], "x": 314.68471626200323, @@ -10436,7 +10452,6 @@ 1 ] }, - 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"Edge", - "SBO:0000167", - "SBO:0000393", - "SBO:0000394", - "DirectedInteraction" + "Edge" ], "zIndex": 12476 }, @@ -10621,8 +10620,6 @@ "b50a0" ], "kaavioType": "Edge", - "markerEnd": "Arrow", - "markerStart": "Arrow", "points": [ { "attachmentDisplay": { @@ -10635,7 +10632,6 @@ 1 ] }, - "id": "a415b", "isAttachedTo": "a0f", "orientation": [ 0, @@ -10655,7 +10651,6 @@ 0 ] }, - "id": "a7240", "isAttachedTo": "b50a0", "orientation": [ 0, @@ -10670,11 +10665,7 @@ "strokeWidth": 1, "type": [ "Interaction", - "Edge", - "SBO:0000167", - "SBO:0000393", - "SBO:0000394", - "DirectedInteraction" + "Edge" ], "zIndex": 12452 }, @@ -10684,7 +10675,7 @@ "gpmlElementName": "Interaction", "id": "id2fb8349f", "isAttachedTo": [ - "d7c34", + "ff97e", "id571a4d12" ], "kaavioType": "Edge", @@ -10701,8 +10692,7 @@ 0.5 ] }, - "id": "f8b5b", - "isAttachedTo": "d7c34", + "isAttachedTo": "ff97e", "orientation": [ -1, 0 @@ -10722,7 +10712,6 @@ 0 ] }, - "id": "f3ae7", "isAttachedTo": "e7a68", "orientation": [], "x": 347.5289169295477, @@ -10759,7 +10748,6 @@ 0.5 ] }, - 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"@base": "http://identifiers.org/wikipathways/WP112/" + "@base": "WP112/" } ], "author": "[Kdahlquist, MaintBot, Thomas, Egonw, Ddigles, Khanspers, AlexanderPico, DeSl, Eweitz]", @@ -16002,27 +15832,27 @@ "decde", "d6e", "e10", - "ebe17", + "d302f", "e00", "f92", "c69", "fdb", - "ad3b9", + "d2abd", "e3146", - "adca6", - "c3c21", + "c8125", + "b35b3", "ee4", - "d83b4", - "f1253", + "f6127", + "e6594", "d76", "cd897", - "efab8", + "f63a0", "c7c", - "d57c0", - "a700a", - "b022f", - "de691", - "b9776", + "abda6", + "b1633", + "b5ba3", + "c2d9f", + "db8db", "c5d", "c61", "b39", @@ -16031,17 +15861,17 @@ "d46", "fc850", "a0f", - "d447d", - "adacc", + "fb169", + "ad7e2", "cd91c", "a7c", - "d7c34", + "ff97e", "e3f", "ebf", - "affe3", + "cb175", "bc2", "fb2", - "d297c", + "a0366", "d7f", "b874c", "ae8", @@ -16090,26 +15920,26 @@ "f1741", "cc0ba", "fb067", - "e6dde", - "b45f0", - "aa47f", + "cba5e", + "a547f", + "d678d", "a9d1a", "d6f0e", - "d70ab", + "cf0a3", "a4c55", "af0de", "b5e4d", - "fff2a", + "d814c", "e1d0a", "b50a0", "ba26e", "a04a4", - 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- + + @@ -1535,8 +1535,8 @@ ACS1 (mt) - - + + @@ -1556,14 +1556,14 @@ RPE1 - + Fructose-6-phosphate - - + + @@ -1607,7 +1607,7 @@ Erythrose-4-phosphate - + Ribulose-5-phosphate @@ -1686,7 +1686,7 @@ Acetate - + Fructose-6-phosphate @@ -1738,8 +1738,8 @@ - - + + @@ -1830,8 +1830,8 @@ - - + + @@ -1846,8 +1846,8 @@ - - + + @@ -1884,8 +1884,8 @@ - - + + @@ -1905,8 +1905,8 @@ - - + + @@ -1932,8 +1932,8 @@ - - + + @@ -1977,8 +1977,8 @@ Fumarate - - + + @@ -2022,8 +2022,8 @@ alpha-ketoglutarate - - + + @@ -2061,8 +2061,8 @@ Succinyl-CoA - - + + @@ -2094,8 +2094,8 @@ FUM1 - - + + @@ -2115,8 +2115,8 @@ MAE1 - - + + @@ -2166,9 +2166,9 @@ - + Name: Principal pathways of carbon metabolism - Last Modified: 20210520114908 + Last Modified: 20240719065429 Organism: Saccharomyces cerevisiae diff --git a/pathways/WP3213/WP3213-bibliography.tsv b/pathways/WP3213/WP3213-bibliography.tsv index 4fa832254..ca0241e4e 100644 --- a/pathways/WP3213/WP3213-bibliography.tsv +++ b/pathways/WP3213/WP3213-bibliography.tsv @@ -1,31 +1,31 @@ ID Database Citation -1280824 Pubmed "Gutch MJ, Daly C, Reich NC. Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor. Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11411–5. PubMed Europe PMC Scholia" -1468582 Pubmed "Novick D, Cohen B, Rubinstein M. Soluble interferon-alpha receptor molecules are present in body fluids. FEBS Lett. 1992 Dec 21;314(3):445–8. PubMed Europe PMC Scholia" -1496401 Pubmed "Schindler C, Shuai K, Prezioso VR, Darnell JE Jr. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992 Aug 7;257(5071):809–13. PubMed Europe PMC Scholia" -1638633 Pubmed "Fu XY. A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s). Cell. 1992 Jul 24;70(2):323–35. PubMed Europe PMC Scholia" -2153461 Pubmed "Uzé G, Lutfalla G, Gresser I. Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. Cell. 1990 Jan 26;60(2):225–34. PubMed Europe PMC Scholia" -7608146 Pubmed "Uddin S, Yenush L, Sun XJ, Sweet ME, White MF, Platanias LC. Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3’-kinase. J Biol Chem. 1995 Jul 7;270(27):15938–41. PubMed Europe PMC Scholia" -7665574 Pubmed "Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, et al. Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. J Biol Chem. 1995 Sep 15;270(37):21606–11. PubMed Europe PMC Scholia" -7988557 Pubmed "Beadling C, Guschin D, Witthuhn BA, Ziemiecki A, Ihle JN, Kerr IM, et al. Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes. EMBO J. 1994 Dec 1;13(23):5605–15. PubMed Europe PMC Scholia" -8181059 Pubmed "Novick D, Cohen B, Rubinstein M. The human interferon alpha/beta receptor: characterization and molecular cloning. Cell. 1994 May 6;77(3):391–400. PubMed Europe PMC Scholia" -8232552 Pubmed "Müller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, et al. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature. 1993 Nov 11;366(6451):129–35. PubMed Europe PMC Scholia" -8496154 Pubmed "Colamonici OR, Domanski P. Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21. J Biol Chem. 1993 May 25;268(15):10895–9. PubMed Europe PMC Scholia" -8524272 Pubmed "David M, Chen HE, Goelz S, Larner AC, Neel BG. Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol Cell Biol. 1995 Dec;15(12):7050–8. PubMed Europe PMC Scholia" -8550573 Pubmed "Platanias LC, Uddin S, Yetter A, Sun XJ, White MF. The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. J Biol Chem. 1996 Jan 5;271(1):278–82. PubMed Europe PMC Scholia" -8628273 Pubmed "Yan H, Krishnan K, Lim JT, Contillo LG, Krolewski JJ. Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction. Mol Cell Biol. 1996 May;16(5):2074–82. PubMed Europe PMC Scholia" -8780698 Pubmed "Uddin S, Gardziola C, Dangat A, Yi T, Platanias LC. Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase. Biochem Biophys Res Commun. 1996 Aug 23;225(3):833–8. PubMed Europe PMC Scholia" -9196040 Pubmed "Uddin S, Sher DA, Alsayed Y, Pons S, Colamonici OR, Fish EN, et al. Interaction of p59fyn with interferon-activated Jak kinases. Biochem Biophys Res Commun. 1997 Jun 9;235(1):83–8. PubMed Europe PMC Scholia" -9287210 Pubmed "Darnell JE Jr. STATs and gene regulation. Science. 1997 Sep 12;277(5332):1630–5. PubMed Europe PMC Scholia" -9295335 Pubmed "Owczarek CM, Hwang SY, Holland KA, Gulluyan LM, Tavaria M, Weaver B, et al. Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2. J Biol Chem. 1997 Sep 19;272(38):23865–70. PubMed Europe PMC Scholia" -9305869 Pubmed "Burfoot MS, Rogers NC, Watling D, Smith JM, Pons S, Paonessaw G, et al. Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. J Biol Chem. 1997 Sep 26;272(39):24183–90. PubMed Europe PMC Scholia" -9326223 Pubmed "Uddin S, Fish EN, Sher D, Gardziola C, Colamonici OR, Kellum M, et al. The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-alpha receptors. Blood. 1997 Oct 1;90(7):2574–82. PubMed Europe PMC Scholia" -9374471 Pubmed "Ahmad S, Alsayed YM, Druker BJ, Platanias LC. The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. J Biol Chem. 1997 Nov 28;272(48):29991–4. PubMed Europe PMC Scholia" -9724754 Pubmed "Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, et al. Inhibition of Stat1-mediated gene activation by PIAS1. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10626–31. PubMed Europe PMC Scholia" -9857039 Pubmed "Song MM, Shuai K. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J Biol Chem. 1998 Dec 25;273(52):35056–62. PubMed Europe PMC Scholia" -9872990 Pubmed "Fish EN, Uddin S, Korkmaz M, Majchrzak B, Druker BJ, Platanias LC. Activation of a CrkL-stat5 signaling complex by type I interferons. J Biol Chem. 1999 Jan 8;274(2):571–3. PubMed Europe PMC Scholia" -10022928 Pubmed "You M, Yu DH, Feng GS. Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. Mol Cell Biol. 1999 Mar;19(3):2416–24. PubMed Europe PMC Scholia" -10428508 Pubmed "Platanias LC, Uddin S, Bruno E, Korkmaz M, Ahmad S, Alsayed Y, et al. CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors. Exp Hematol. 1999 Aug;27(8):1315–21. PubMed Europe PMC Scholia" -10514501 Pubmed "Uddin S, Majchrzak B, Woodson J, Arunkumar P, Alsayed Y, Pine R, et al. Activation of the p38 mitogen-activated protein kinase by type I interferons. J Biol Chem. 1999 Oct 15;274(42):30127–31. PubMed Europe PMC Scholia" -10644731 Pubmed "Farrar JD, Smith JD, Murphy TL, Murphy KM. Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2. J Biol Chem. 2000 Jan 28;275(4):2693–7. PubMed Europe PMC Scholia" -17604604 Pubmed "Baychelier F, Nardeux P-C, Cajean-Feroldi C, Ermonval M, Guymarho J, Tovey MG, et al. Involvement of the Gab2 scaffolding adapter in type I interferon signalling. Cell Signal. 2007 Oct;19(10):2080–7. PubMed Europe PMC Scholia" -24696235 Pubmed "Samarajiwa SA, Mangan NE, Hardy MP, Najdovska M, Dubach D, Braniff S-J, et al. Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock. J Immunol. 2014 May 1;192(9):4425–35. PubMed Europe PMC Scholia" +1280824 Pubmed "Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor. Gutch MJ, Daly C, Reich NC. Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11411–5. PubMed Europe PMC Scholia" +1468582 Pubmed "Soluble interferon-alpha receptor molecules are present in body fluids. Novick D, Cohen B, Rubinstein M. FEBS Lett. 1992 Dec 21;314(3):445–8. PubMed Europe PMC Scholia" +1496401 Pubmed "Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Schindler C, Shuai K, Prezioso VR, Darnell JE Jr. Science. 1992 Aug 7;257(5071):809–13. PubMed Europe PMC Scholia" +1638633 Pubmed "A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s). Fu XY. Cell. 1992 Jul 24;70(2):323–35. PubMed Europe PMC Scholia" +2153461 Pubmed "Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. Uzé G, Lutfalla G, Gresser I. Cell. 1990 Jan 26;60(2):225–34. PubMed Europe PMC Scholia" +7608146 Pubmed "Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3’-kinase. Uddin S, Yenush L, Sun XJ, Sweet ME, White MF, Platanias LC. J Biol Chem. 1995 Jul 7;270(27):15938–41. PubMed Europe PMC Scholia" +7665574 Pubmed "Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, et al. J Biol Chem. 1995 Sep 15;270(37):21606–11. PubMed Europe PMC Scholia" +7988557 Pubmed "Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes. Beadling C, Guschin D, Witthuhn BA, Ziemiecki A, Ihle JN, Kerr IM, et al. EMBO J. 1994 Dec 1;13(23):5605–15. PubMed Europe PMC Scholia" +8181059 Pubmed "The human interferon alpha/beta receptor: characterization and molecular cloning. Novick D, Cohen B, Rubinstein M. Cell. 1994 May 6;77(3):391–400. PubMed Europe PMC Scholia" +8232552 Pubmed "The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Müller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, et al. Nature. 1993 Nov 11;366(6451):129–35. PubMed Europe PMC Scholia" +8496154 Pubmed "Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21. Colamonici OR, Domanski P. J Biol Chem. 1993 May 25;268(15):10895–9. PubMed Europe PMC Scholia" +8524272 Pubmed "Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. David M, Chen HE, Goelz S, Larner AC, Neel BG. Mol Cell Biol. 1995 Dec;15(12):7050–8. PubMed Europe PMC Scholia" +8550573 Pubmed "The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. Platanias LC, Uddin S, Yetter A, Sun XJ, White MF. J Biol Chem. 1996 Jan 5;271(1):278–82. PubMed Europe PMC Scholia" +8628273 Pubmed "Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction. Yan H, Krishnan K, Lim JT, Contillo LG, Krolewski JJ. Mol Cell Biol. 1996 May;16(5):2074–82. PubMed Europe PMC Scholia" +8780698 Pubmed "Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase. Uddin S, Gardziola C, Dangat A, Yi T, Platanias LC. Biochem Biophys Res Commun. 1996 Aug 23;225(3):833–8. PubMed Europe PMC Scholia" +9196040 Pubmed "Interaction of p59fyn with interferon-activated Jak kinases. Uddin S, Sher DA, Alsayed Y, Pons S, Colamonici OR, Fish EN, et al. Biochem Biophys Res Commun. 1997 Jun 9;235(1):83–8. PubMed Europe PMC Scholia" +9287210 Pubmed "STATs and gene regulation. Darnell JE Jr. Science. 1997 Sep 12;277(5332):1630–5. PubMed Europe PMC Scholia" +9295335 Pubmed "Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2. Owczarek CM, Hwang SY, Holland KA, Gulluyan LM, Tavaria M, Weaver B, et al. J Biol Chem. 1997 Sep 19;272(38):23865–70. PubMed Europe PMC Scholia" +9305869 Pubmed "Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. Burfoot MS, Rogers NC, Watling D, Smith JM, Pons S, Paonessaw G, et al. J Biol Chem. 1997 Sep 26;272(39):24183–90. PubMed Europe PMC Scholia" +9326223 Pubmed "The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-alpha receptors. Uddin S, Fish EN, Sher D, Gardziola C, Colamonici OR, Kellum M, et al. Blood. 1997 Oct 1;90(7):2574–82. PubMed Europe PMC Scholia" +9374471 Pubmed "The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. Ahmad S, Alsayed YM, Druker BJ, Platanias LC. J Biol Chem. 1997 Nov 28;272(48):29991–4. PubMed Europe PMC Scholia" +9724754 Pubmed "Inhibition of Stat1-mediated gene activation by PIAS1. Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, et al. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10626–31. PubMed Europe PMC Scholia" +9857039 Pubmed "The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. Song MM, Shuai K. J Biol Chem. 1998 Dec 25;273(52):35056–62. PubMed Europe PMC Scholia" +9872990 Pubmed "Activation of a CrkL-stat5 signaling complex by type I interferons. Fish EN, Uddin S, Korkmaz M, Majchrzak B, Druker BJ, Platanias LC. J Biol Chem. 1999 Jan 8;274(2):571–3. PubMed Europe PMC Scholia" +10022928 Pubmed "Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. You M, Yu DH, Feng GS. Mol Cell Biol. 1999 Mar;19(3):2416–24. PubMed Europe PMC Scholia" +10428508 Pubmed "CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors. Platanias LC, Uddin S, Bruno E, Korkmaz M, Ahmad S, Alsayed Y, et al. Exp Hematol. 1999 Aug;27(8):1315–21. PubMed Europe PMC Scholia" +10514501 Pubmed "Activation of the p38 mitogen-activated protein kinase by type I interferons. Uddin S, Majchrzak B, Woodson J, Arunkumar P, Alsayed Y, Pine R, et al. J Biol Chem. 1999 Oct 15;274(42):30127–31. PubMed Europe PMC Scholia" +10644731 Pubmed "Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2. Farrar JD, Smith JD, Murphy TL, Murphy KM. J Biol Chem. 2000 Jan 28;275(4):2693–7. PubMed Europe PMC Scholia" +17604604 Pubmed "Involvement of the Gab2 scaffolding adapter in type I interferon signalling. Baychelier F, Nardeux PC, Cajean-Feroldi C, Ermonval M, Guymarho J, Tovey MG, et al. Cell Signal. 2007 Oct;19(10):2080–7. PubMed Europe PMC Scholia" +24696235 Pubmed "Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock. Samarajiwa SA, Mangan NE, Hardy MP, Najdovska M, Dubach D, Braniff SJ, et al. J Immunol. 2014 May 1;192(9):4425–35. PubMed Europe PMC Scholia" diff --git a/pathways/WP3213/WP3213-datanodes.tsv b/pathways/WP3213/WP3213-datanodes.tsv index 8cab88387..4c059693e 100644 --- a/pathways/WP3213/WP3213-datanodes.tsv +++ b/pathways/WP3213/WP3213-datanodes.tsv @@ -1,69 +1,56 @@ -Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI -GTP Metabolite chebi:15996 wikidata:Q392227 chebi:15996;chebi:15996 inchikey:XKMLYUALXHKNFT-UUOKFMHZSA-N -GDP Metabolite chebi:17552 wikidata:Q422582 chebi:17552;chebi:17552 inchikey:QGWNDRXFNXRZMB-UUOKFMHZSA-N -CRK GeneProduct ensembl:ENSBTAG00000005665 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398 ensembl:ENSBTAG00000005665 ncbigene:512841 uniprot:E1BQ32 -PTPN6 GeneProduct ensembl:ENSBTAG00000020294 SHP1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5777 ensembl:ENSBTAG00000020294 ncbigene:512312 uniprot:A0A3Q1LU97;uniprot:A0A3Q1M739;uniprot:A5D980 -JAK1 GeneProduct ensembl:ENSBTAG00000003147 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716 ensembl:ENSBTAG00000003147 ncbigene:537201 uniprot:F1N0D6 -PIAS1 GeneProduct ensembl:ENSBTAG00000005564 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8554 ensembl:ENSBTAG00000005564 ncbigene:509231 uniprot:Q24JZ9;uniprot:A0A3Q1NE62;uniprot:A0A3Q1ML58;uniprot:F6QRK7 -FYN GeneProduct ensembl:ENSBTAG00000011851 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534 ensembl:ENSBTAG00000011851 ncbigene:527263 uniprot:A0JNB0 -PTPN11 GeneProduct ensembl:ENSBTAG00000002048 SHP2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781 ensembl:ENSBTAG00000002048 ncbigene:533590 uniprot:F1N339 -ZAP70 GeneProduct ensembl:ENSBTAG00000005892 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7535 ensembl:ENSBTAG00000005892 ncbigene:504509 uniprot:E1BMP9 -PTPRC GeneProduct ensembl:ENSBTAG00000023144 CD45
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5788 ensembl:ENSBTAG00000023144 ncbigene:407152 uniprot:F1MJS9 -PIAS3 GeneProduct ensembl:ENSBTAG00000021634 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10401 ensembl:ENSBTAG00000021634 ncbigene:535312 uniprot:A6QQU9;uniprot:A0A3Q1LMC0 -LCK GeneProduct ensembl:ENSBTAG00000012695 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3932 ensembl:ENSBTAG00000012695 ncbigene:508890 uniprot:A0A3Q1MDN9;uniprot:Q3ZCM0 -CBL Protein ensembl:ENSBTAG00000006817 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:867 ensembl:ENSBTAG00000006817 ncbigene:527418 uniprot:E1BJS3;uniprot:A0A3Q1LN00 -RAPGEF1 Protein ensembl:ENSBTAG00000020791 C3G
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2889 ensembl:ENSBTAG00000020791 ncbigene:520454 uniprot:A0A3Q1M4X5;uniprot:A0A3Q1LXN8;uniprot:A0A3Q1LPP9;uniprot:F1MJY2;uniprot:A0A3Q1MCQ4;uniprot:A0A3Q1N3N1;uniprot:A0A3Q1LHU3 -RPS6KB1 Protein ensembl:ENSBTAG00000016851 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198 ensembl:ENSBTAG00000016851 ncbigene:404181 uniprot:F1MNP4 -IFNAR2 Protein ensembl:ENSBTAG00000015212 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3455 ensembl:ENSBTAG00000015212 ncbigene:282258 uniprot:F1MXT2 -MAPKAP1 Protein ensembl:ENSBTAG00000010271 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79109 ensembl:ENSBTAG00000010271 ncbigene:533861 uniprot:A0A3Q1N455;uniprot:A0A3Q1LWN3;uniprot:A2VDU2 -CRKL Protein ensembl:ENSBTAG00000045548 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399 ensembl:ENSBTAG00000045548 ncbigene:518180 uniprot:G3N016 -EIF4E Protein ensembl:ENSBTAG00000009522 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1977 ensembl:ENSBTAG00000009522 ncbigene:281751 uniprot:A0A3Q1NEI6;uniprot:A0A452DJ21 -EIF4EBP1 Protein ensembl:ENSBTAG00000027654 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978 ensembl:ENSBTAG00000027654 ncbigene:509613 uniprot:Q0P5A7 -RPTOR Protein ensembl:ENSBTAG00000002883 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57521 ensembl:ENSBTAG00000002883 ncbigene:507056 uniprot:F1MG06 -PDCD4 Protein ensembl:ENSBTAG00000019434 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27250 ensembl:ENSBTAG00000019434 ncbigene:506724 uniprot:A4IFD1;uniprot:A0A3Q1MZU3 -STAT3 Protein ensembl:ENSBTAG00000021523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774 ensembl:ENSBTAG00000021523 ncbigene:508541 uniprot:F1MX38 -IRS1 Protein ensembl:ENSBTAG00000021308 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3667 ensembl:ENSBTAG00000021308 uniprot:F1MYE0 -SOCS1 Protein ensembl:ENSBTAG00000004386 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651 ensembl:ENSBTAG00000004386 ncbigene:518795 uniprot:M5FKB1;uniprot:F1MSN0 -SOCS3 Protein ensembl:ENSBTAG00000008441 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9021 ensembl:ENSBTAG00000008441 ncbigene:282081 uniprot:Q9BEG9 -IFNAR1 Protein ensembl:ENSBTAG00000021819 INTERFERON RECEPTOR
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3454 ensembl:ENSBTAG00000021819 ncbigene:282257 uniprot:Q04790 -STAT1 Protein ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772 ensembl:ENSBTAG00000007867 ncbigene:510814 uniprot:A0A3Q1ME65;uniprot:E1BPP7;uniprot:A0A3S5ZPJ6 -STAT2 Protein ensembl:ENSBTAG00000004380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773 ensembl:ENSBTAG00000004380 ncbigene:511023 uniprot:E1B8Z4 -EIF4B Protein ensembl:ENSBTAG00000006883 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1975 ensembl:ENSBTAG00000006883 ncbigene:505850 uniprot:F1MYS7;uniprot:A0A3Q1N2J5;uniprot:A0A3Q1MRD9;uniprot:A0A3Q1N3Q6 -PIK3CD Protein ensembl:ENSBTAG00000018984 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5293 ensembl:ENSBTAG00000018984 ncbigene:504531 uniprot:A0A3Q1MD55;uniprot:E1BE66 -RAC1 Protein ensembl:ENSBTAG00000009233 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879 -MAP2K3 Protein ensembl:ENSBTAG00000010576 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606 ensembl:ENSBTAG00000010576 ncbigene:516039 uniprot:A0A3Q1N5Y6;uniprot:A0A3Q1LL86;uniprot:F6S1D0;uniprot:A0A3Q1MNG1 -STAT4 Protein ensembl:ENSBTAG00000046699 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6775 ensembl:ENSBTAG00000046699 ncbigene:515988 uniprot:F1N0R2 -CRKL Protein ensembl:ENSBTAG00000045548 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399 ensembl:ENSBTAG00000045548 ncbigene:518180 uniprot:G3N016 -RPS6KA4 Protein ensembl:ENSBTAG00000039153 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8986 ensembl:ENSBTAG00000039153 ncbigene:523746 uniprot:F1MQE1 -STAT4 Protein ensembl:ENSBTAG00000046699 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6775 ensembl:ENSBTAG00000046699 ncbigene:515988 uniprot:F1N0R2 -TYK2 Protein ensembl:ENSBTAG00000011698 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7297 ensembl:ENSBTAG00000011698 ncbigene:512484 uniprot:F1MCX4 -MTOR Protein ensembl:ENSBTAG00000015325 AKT
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HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475 ensembl:ENSBTAG00000015325 ncbigene:100139219 uniprot:A0A3Q1MEZ6;uniprot:E1BFB4;uniprot:A0A3Q1LUE8;uniprot:A0A3Q1MN73;uniprot:A0A3Q1MZG6;uniprot:A0A3Q1M2S6;uniprot:A0A3Q1MIZ9 -MLST8 Protein ensembl:ENSBTAG00000009928 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64223 ensembl:ENSBTAG00000009928 ncbigene:535236 uniprot:Q17QU5 -EIF4A1 Protein ensembl:ENSBTAG00000000132 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1973 ensembl:ENSBTAG00000000132 ncbigene:504958 uniprot:Q3SZ54 -REL Protein ensembl:ENSBTAG00000015386 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5966 ensembl:ENSBTAG00000015386 ncbigene:509135 uniprot:F1MJH6 -CREB1 Protein ensembl:ENSBTAG00000005474 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385 ensembl:ENSBTAG00000005474 ncbigene:281713 uniprot:Q0V7N6 -STAT5A Protein ensembl:ENSBTAG00000009496 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776 ensembl:ENSBTAG00000009496 ncbigene:282375 uniprot:Q95115;uniprot:F1MER9 -PRMT1 Protein ensembl:ENSBTAG00000001357 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3276 -MAP2K6 Protein ensembl:ENSBTAG00000001609 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608 ensembl:ENSBTAG00000001609 ncbigene:286883 uniprot:Q5E9X2;uniprot:A0A3Q1M703;uniprot:A0A3Q1LLK9 -STAT2 Protein ensembl:ENSBTAG00000004380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773 ensembl:ENSBTAG00000004380 ncbigene:511023 uniprot:E1B8Z4 -MTOR Protein ensembl:ENSBTAG00000015325 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475 ensembl:ENSBTAG00000015325 ncbigene:100139219 uniprot:A0A3Q1MEZ6;uniprot:E1BFB4;uniprot:A0A3Q1LUE8;uniprot:A0A3Q1MN73;uniprot:A0A3Q1MZG6;uniprot:A0A3Q1M2S6;uniprot:A0A3Q1MIZ9 -RAP1A Protein ensembl:ENSBTAG00000014710 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906 -IRS2 Protein ensembl:ENSBTAG00000012019 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660 ensembl:ENSBTAG00000012019 uniprot:F1MJE0 -RPS6KA5 Protein ensembl:ENSBTAG00000010906 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9252 ensembl:ENSBTAG00000010906 ncbigene:504408 uniprot:E1BN61;uniprot:A0A3Q1LRM7;uniprot:A0A3Q1MUT9 -PIK3R1 Protein ensembl:ENSBTAG00000010989 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295 ensembl:ENSBTAG00000010989 ncbigene:282307 uniprot:P23727;uniprot:A0A3Q1LW04;uniprot:A0A3Q1M401 -VAV1 Protein ensembl:ENSBTAG00000039160 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7409 ensembl:ENSBTAG00000039160 ncbigene:617345 uniprot:F1MSK3;uniprot:Q08DN7 -RPS6 Protein ensembl:ENSBTAG00000014449 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194 ensembl:ENSBTAG00000014449 uniprot:E1B8K9 -MAP3K1 Protein ensembl:ENSBTAG00000013790 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214 ensembl:ENSBTAG00000013790 ncbigene:523962 uniprot:E1B847 -GNB2L1 Protein ensembl:ENSBTAG00000019648 RACK1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10399 ensembl:ENSBTAG00000019648 ncbigene:327682 uniprot:P63243;uniprot:A0A3Q1M0K2 -MAPK14 Protein ensembl:ENSBTAG00000020783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432 ensembl:ENSBTAG00000020783 ncbigene:534492 uniprot:F6PU21;uniprot:A0A3Q1LTT9;uniprot:A0A3Q1M517;uniprot:A0A3Q1M8H8 -IFNAR2 Protein ensembl:ENSBTAG00000015212 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3455 ensembl:ENSBTAG00000015212 ncbigene:282258 uniprot:F1MXT2 -STAT1 Protein ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772 ensembl:ENSBTAG00000007867 ncbigene:510814 uniprot:A0A3Q1ME65;uniprot:E1BPP7;uniprot:A0A3S5ZPJ6 -STAT1 Protein ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772 ensembl:ENSBTAG00000007867 ncbigene:510814 uniprot:A0A3Q1ME65;uniprot:E1BPP7;uniprot:A0A3S5ZPJ6 -IFNAR2 Protein ensembl:ENSBTAG00000015212 INTERFERON RECEPTOR
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3455 ensembl:ENSBTAG00000015212 ncbigene:282258 uniprot:F1MXT2 -STAT3 Protein ensembl:ENSBTAG00000021523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774 ensembl:ENSBTAG00000021523 ncbigene:508541 uniprot:F1MX38 -RAC1 Protein ensembl:ENSBTAG00000009233 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879 -STAT1 Protein ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772 ensembl:ENSBTAG00000007867 ncbigene:510814 uniprot:A0A3Q1ME65;uniprot:E1BPP7;uniprot:A0A3S5ZPJ6 -STAT3 Protein ensembl:ENSBTAG00000021523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774 ensembl:ENSBTAG00000021523 ncbigene:508541 uniprot:F1MX38 -STAT3 Protein ensembl:ENSBTAG00000021523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774 ensembl:ENSBTAG00000021523 ncbigene:508541 uniprot:F1MX38 -STAT1 Protein ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772 ensembl:ENSBTAG00000007867 ncbigene:510814 uniprot:A0A3Q1ME65;uniprot:E1BPP7;uniprot:A0A3S5ZPJ6 -STAT2 Protein ensembl:ENSBTAG00000004380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773 ensembl:ENSBTAG00000004380 ncbigene:511023 uniprot:E1B8Z4 +Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps +GTP Metabolite chebi:15996 "" wikidata:Q392227 chebi:15996 inchikey:XKMLYUALXHKNFT-UUOKFMHZSA-N pubchem.compound:6830 chemspider:6569 hmdb:HMDB0001273 kegg.compound:C00044 +GDP Metabolite chebi:17552 "" wikidata:Q422582 chebi:17552 inchikey:QGWNDRXFNXRZMB-UUOKFMHZSA-N pubchem.compound:8977 chemspider:8630 hmdb:HMDB0001201 kegg.compound:C00035 +CRK GeneProduct ensembl:ENSBTAG00000005665 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398" ensembl:ENSBTAG00000005665 ncbigene:512841 uniprot:E1BQ32 +PTPN6 GeneProduct ensembl:ENSBTAG00000020294 "SHP1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5777" ensembl:ENSBTAG00000020294 ncbigene:512312 uniprot:A0A3Q1LU97;uniprot:A0A3Q1M739;uniprot:A5D980 +JAK1 GeneProduct ensembl:ENSBTAG00000003147 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716" ensembl:ENSBTAG00000003147 ncbigene:537201 uniprot:F1N0D6 +PIAS1 GeneProduct ensembl:ENSBTAG00000005564 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8554" ensembl:ENSBTAG00000005564 ncbigene:509231 uniprot:Q24JZ9;uniprot:A0A3Q1NE62;uniprot:A0A3Q1ML58;uniprot:F6QRK7 +FYN GeneProduct ensembl:ENSBTAG00000011851 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534" ensembl:ENSBTAG00000011851 ncbigene:527263 uniprot:A0JNB0 +PTPN11 GeneProduct ensembl:ENSBTAG00000002048 "SHP2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781" ensembl:ENSBTAG00000002048 ncbigene:533590 uniprot:F1N339 +ZAP70 GeneProduct ensembl:ENSBTAG00000005892 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7535" ensembl:ENSBTAG00000005892 ncbigene:504509 uniprot:E1BMP9 +PTPRC GeneProduct ensembl:ENSBTAG00000023144 "CD45
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5788" ensembl:ENSBTAG00000023144 ncbigene:407152 uniprot:F1MJS9 +PIAS3 GeneProduct ensembl:ENSBTAG00000021634 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10401" ensembl:ENSBTAG00000021634 ncbigene:535312 uniprot:A6QQU9;uniprot:A0A3Q1LMC0 +LCK GeneProduct ensembl:ENSBTAG00000012695 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3932" ensembl:ENSBTAG00000012695 ncbigene:508890 uniprot:A0A3Q1MDN9;uniprot:Q3ZCM0 +CBL Protein ensembl:ENSBTAG00000006817 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:867" ensembl:ENSBTAG00000006817 ncbigene:527418 uniprot:E1BJS3;uniprot:A0A3Q1LN00 +RAPGEF1 Protein ensembl:ENSBTAG00000020791 "C3G
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2889" ensembl:ENSBTAG00000020791 ncbigene:520454 uniprot:A0A3Q1M4X5;uniprot:A0A3Q1LXN8;uniprot:A0A3Q1LPP9;uniprot:F1MJY2;uniprot:A0A3Q1MCQ4;uniprot:A0A3Q1N3N1;uniprot:A0A3Q1LHU3 +RPS6KB1 Protein ensembl:ENSBTAG00000016851 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198 " ensembl:ENSBTAG00000016851 ncbigene:404181 uniprot:F1MNP4 +IFNAR2 Protein ensembl:ENSBTAG00000015212 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3455" ensembl:ENSBTAG00000015212 ncbigene:282258 uniprot:F1MXT2 +MAPKAP1 Protein ensembl:ENSBTAG00000010271 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79109" ensembl:ENSBTAG00000010271 ncbigene:533861 uniprot:A0A3Q1N455;uniprot:A0A3Q1LWN3;uniprot:A2VDU2 +CRKL Protein ensembl:ENSBTAG00000045548 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399" ensembl:ENSBTAG00000045548 ncbigene:518180 uniprot:G3N016 +EIF4E Protein ensembl:ENSBTAG00000009522 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1977" ensembl:ENSBTAG00000009522 ncbigene:281751 uniprot:A0A3Q1NEI6;uniprot:A0A452DJ21 +EIF4EBP1 Protein ensembl:ENSBTAG00000027654 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978" ensembl:ENSBTAG00000027654 ncbigene:509613 uniprot:Q0P5A7 +RPTOR Protein ensembl:ENSBTAG00000002883 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57521" ensembl:ENSBTAG00000002883 ncbigene:507056 uniprot:F1MG06 +PDCD4 Protein ensembl:ENSBTAG00000019434 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27250 " ensembl:ENSBTAG00000019434 ncbigene:506724 uniprot:A4IFD1;uniprot:A0A3Q1MZU3 +STAT3 Protein ensembl:ENSBTAG00000021523 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774" ensembl:ENSBTAG00000021523 ncbigene:508541 uniprot:F1MX38 +IRS1 Protein ensembl:ENSBTAG00000021308 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3667" ensembl:ENSBTAG00000021308 uniprot:F1MYE0 +SOCS1 Protein ensembl:ENSBTAG00000004386 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651" ensembl:ENSBTAG00000004386 ncbigene:518795 uniprot:F1MSN0 +SOCS3 Protein ensembl:ENSBTAG00000008441 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9021" ensembl:ENSBTAG00000008441 ncbigene:282081 uniprot:Q9BEG9 +IFNAR1 Protein ensembl:ENSBTAG00000021819 "INTERFERON RECEPTOR
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3454" ensembl:ENSBTAG00000021819 ncbigene:282257 uniprot:Q04790 +STAT1 Protein ensembl:ENSBTAG00000007867 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772" ensembl:ENSBTAG00000007867 ncbigene:510814 uniprot:A0A3Q1ME65;uniprot:E1BPP7;uniprot:A0A3S5ZPJ6 +STAT2 Protein ensembl:ENSBTAG00000004380 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773" ensembl:ENSBTAG00000004380 ncbigene:511023 uniprot:E1B8Z4 +EIF4B Protein ensembl:ENSBTAG00000006883 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1975" ensembl:ENSBTAG00000006883 ncbigene:505850 uniprot:F1MYS7;uniprot:A0A3Q1N2J5;uniprot:A0A3Q1MRD9;uniprot:A0A3Q1N3Q6 +PIK3CD Protein ensembl:ENSBTAG00000018984 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5293" ensembl:ENSBTAG00000018984 ncbigene:504531 uniprot:A0A3Q1MD55;uniprot:E1BE66 +RAC1 Protein ensembl:ENSBTAG00000009233 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879" +MAP2K3 Protein ensembl:ENSBTAG00000010576 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606" ensembl:ENSBTAG00000010576 ncbigene:516039 uniprot:A0A3Q1N5Y6;uniprot:A0A3Q1LL86;uniprot:F6S1D0;uniprot:A0A3Q1MNG1 +STAT4 Protein ensembl:ENSBTAG00000046699 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6775" ensembl:ENSBTAG00000046699 ncbigene:515988 uniprot:F1N0R2 +RPS6KA4 Protein ensembl:ENSBTAG00000039153 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8986" ensembl:ENSBTAG00000039153 ncbigene:523746 uniprot:F1MQE1 +TYK2 Protein ensembl:ENSBTAG00000011698 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7297" ensembl:ENSBTAG00000011698 ncbigene:512484 uniprot:F1MCX4 +MTOR Protein ensembl:ENSBTAG00000015325 "AKT
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475" ensembl:ENSBTAG00000015325 ncbigene:100139219 uniprot:A0A3Q1MEZ6;uniprot:E1BFB4;uniprot:A0A3Q1LUE8;uniprot:A0A3Q1MN73;uniprot:A0A3Q1MZG6;uniprot:A0A3Q1M2S6;uniprot:A0A3Q1MIZ9 +MLST8 Protein ensembl:ENSBTAG00000009928 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64223" ensembl:ENSBTAG00000009928 ncbigene:535236 uniprot:Q17QU5 +EIF4A1 Protein ensembl:ENSBTAG00000000132 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1973 " ensembl:ENSBTAG00000000132 ncbigene:504958 uniprot:Q3SZ54 +REL Protein ensembl:ENSBTAG00000015386 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5966 " ensembl:ENSBTAG00000015386 ncbigene:509135 uniprot:F1MJH6 +CREB1 Protein ensembl:ENSBTAG00000005474 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385" ensembl:ENSBTAG00000005474 ncbigene:281713 uniprot:Q0V7N6 +STAT5A Protein ensembl:ENSBTAG00000009496 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776" ensembl:ENSBTAG00000009496 ncbigene:282375 uniprot:Q95115;uniprot:F1MER9 +PRMT1 Protein ensembl:ENSBTAG00000001357 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3276" +MAP2K6 Protein ensembl:ENSBTAG00000001609 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608" ensembl:ENSBTAG00000001609 ncbigene:286883 uniprot:Q5E9X2;uniprot:A0A3Q1M703;uniprot:A0A3Q1LLK9 +MTOR Protein ensembl:ENSBTAG00000015325 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475" ensembl:ENSBTAG00000015325 ncbigene:100139219 uniprot:A0A3Q1MEZ6;uniprot:E1BFB4;uniprot:A0A3Q1LUE8;uniprot:A0A3Q1MN73;uniprot:A0A3Q1MZG6;uniprot:A0A3Q1M2S6;uniprot:A0A3Q1MIZ9 +RAP1A Protein ensembl:ENSBTAG00000014710 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906" +IRS2 Protein ensembl:ENSBTAG00000012019 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660" ensembl:ENSBTAG00000012019 uniprot:F1MJE0 +RPS6KA5 Protein ensembl:ENSBTAG00000010906 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9252" ensembl:ENSBTAG00000010906 ncbigene:504408 uniprot:E1BN61;uniprot:A0A3Q1LRM7;uniprot:A0A3Q1MUT9 +PIK3R1 Protein ensembl:ENSBTAG00000010989 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295" ensembl:ENSBTAG00000010989 ncbigene:282307 uniprot:P23727;uniprot:A0A3Q1LW04;uniprot:A0A3Q1M401 +VAV1 Protein ensembl:ENSBTAG00000039160 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7409" ensembl:ENSBTAG00000039160 ncbigene:617345 uniprot:F1MSK3;uniprot:Q08DN7 +RPS6 Protein ensembl:ENSBTAG00000014449 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194 " ensembl:ENSBTAG00000014449 uniprot:E1B8K9 +MAP3K1 Protein ensembl:ENSBTAG00000013790 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214" ensembl:ENSBTAG00000013790 ncbigene:523962 uniprot:E1B847 +GNB2L1 Protein ensembl:ENSBTAG00000019648 "RACK1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10399" ensembl:ENSBTAG00000019648 ncbigene:327682 uniprot:P63243;uniprot:A0A3Q1M0K2 +MAPK14 Protein ensembl:ENSBTAG00000020783 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432" ensembl:ENSBTAG00000020783 ncbigene:534492 uniprot:F6PU21;uniprot:A0A3Q1LTT9;uniprot:A0A3Q1M517;uniprot:A0A3Q1M8H8 +IFNAR2 Protein ensembl:ENSBTAG00000015212 "INTERFERON RECEPTOR
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3455" ensembl:ENSBTAG00000015212 ncbigene:282258 uniprot:F1MXT2 diff --git a/pathways/WP3213/WP3213.gpml b/pathways/WP3213/WP3213.gpml index ee19ec248..f8c0b6a6f 100644 --- a/pathways/WP3213/WP3213.gpml +++ b/pathways/WP3213/WP3213.gpml @@ -1,7 +1,7 @@ - - The type I IFNs (IFNα family, IFNβ, IFNω, IFNε and IFNκ) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other accessory proteins. The pathway above (WP585) describes the Type I Interferon signaling pathways and shows both classical IFN signaling via the JAK-STAT pathway (dark lines) and other non-canonical IFN signaling pathways. - Type your comment here + + The type I IFNs (IFNα family, IFNβ, IFNω, IFNε and IFNκ) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other accessory proteins. The pathway above (WP585) describes the Type I Interferon signaling pathways and shows both classical IFN signaling via the JAK-STAT pathway (dark lines) and other non-canonical IFN signaling pathways. + This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP585_r80201 WP585(80201)] with a 95.0% conversion rate. @@ -29,7 +29,7 @@ - HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198 + HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198 @@ -89,7 +89,7 @@ - HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27250 + HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27250 @@ -222,7 +222,6 @@ AKT - Type your comment here HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475 @@ -233,7 +232,7 @@ - HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1973 + HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1973 @@ -243,7 +242,7 @@ - HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5966 + HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5966 @@ -305,7 +304,7 @@ - HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194 + HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194 @@ -397,562 +396,562 @@ - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + @@ -1023,7 +1022,6 @@ in CD4(+) T-Cells - Type your comment here @@ -1050,7 +1048,6 @@ in CD4(+) T-Cells - Type your comment here @@ -1131,58 +1128,100 @@ - - - - + + + + e58 - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + - - Jak-Stat signaling pathway - PW:0000209 - Pathway Ontology - - - immune response pathway - PW:0000023 - Pathway Ontology - - - 10514501 + + 8524272 PubMed - Activation of the p38 mitogen-activated protein kinase by type I interferons. - J Biol Chem - 1999 + Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. + Mol Cell Biol + 1995 + David M + Chen HE + Goelz S + Larner AC + Neel BG + + + 9196040 + PubMed + Interaction of p59fyn with interferon-activated Jak kinases. + Biochem Biophys Res Commun + 1997 Uddin S - Majchrzak B - Woodson J - Arunkumar P + Sher DA Alsayed Y - Pine R - Young PR + Pons S + Colamonici OR Fish EN + White MF Platanias LC + + 8628273 + PubMed + Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction. + Mol Cell Biol + 1996 + Yan H + Krishnan K + Lim JT + Contillo LG + Krolewski JJ + + + 2153461 + PubMed + Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. + Cell + 1990 + Uzé G + Lutfalla G + Gresser I + + + 21934092 + PubMed + MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4. + Carcinogenesis + 2011 + Liu X + Zhang Z + Sun L + Chai N + Tang S + Jin J + Hu H + Nie Y + Wang X + Wu K + Jin H + Fan D + 9872990 PubMed @@ -1196,6 +1235,73 @@ Druker BJ Platanias LC + + 9305869 + PubMed + Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. + J Biol Chem + 1997 + Burfoot MS + Rogers NC + Watling D + Smith JM + Pons S + Paonessaw G + Pellegrini S + White MF + Kerr IM + + + Jak-Stat signaling pathway + PW:0000209 + Pathway Ontology + + + 1468582 + PubMed + Soluble interferon-alpha receptor molecules are present in body fluids. + FEBS Lett + 1992 + Novick D + Cohen B + Rubinstein M + + + 9857039 + PubMed + The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. + J Biol Chem + 1998 + Song MM + Shuai K + + + 10644731 + PubMed + Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2. + J Biol Chem + 2000 + Farrar JD + Smith JD + Murphy TL + Murphy KM + + + 9295335 + PubMed + Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2. + J Biol Chem + 1997 + Owczarek CM + Hwang SY + Holland KA + Gulluyan LM + Tavaria M + Weaver B + Reich NC + Kola I + Hertzog PJ + 9326223 PubMed @@ -1212,34 +1318,38 @@ White MF Platanias LC - - 1638633 - PubMed - A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s). - Cell - 1992 - Fu XY - - - 1496401 + + 8232552 PubMed - Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. - Science - 1992 + The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. + Nature + 1993 + Müller M + Briscoe J + Laxton C + Guschin D + Ziemiecki A + Silvennoinen O + Harpur AG + Barbieri G + Witthuhn BA Schindler C - Shuai K - Prezioso VR - Darnell JE Jr - - 1280824 + + 10514501 PubMed - Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor. - Proc Natl Acad Sci U S A - 1992 - Gutch MJ - Daly C - Reich NC + Activation of the p38 mitogen-activated protein kinase by type I interferons. + J Biol Chem + 1999 + Uddin S + Majchrzak B + Woodson J + Arunkumar P + Alsayed Y + Pine R + Young PR + Fish EN + Platanias LC 7988557 @@ -1255,28 +1365,6 @@ Kerr IM Cantrell DA - - 9287210 - PubMed - STATs and gene regulation. - Science - 1997 - Darnell JE Jr - - - 17604604 - PubMed - Involvement of the Gab2 scaffolding adapter in type I interferon signalling. - Cell Signal - 2007 - Baychelier F - Nardeux PC - Cajean-Feroldi C - Ermonval M - Guymarho J - Tovey MG - Eid P - 10428508 PubMed @@ -1294,17 +1382,25 @@ Wickrema A Hoffman R - - 8780698 + + 1638633 PubMed - Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase. - Biochem Biophys Res Commun + A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s). + Cell + 1992 + Fu XY + + + 8550573 + PubMed + The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. + J Biol Chem 1996 - Uddin S - Gardziola C - Dangat A - Yi T Platanias LC + Uddin S + Yetter A + Sun XJ + White MF 7665574 @@ -1320,38 +1416,15 @@ Pitha P Colamonici OR - - 8232552 - PubMed - The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. - Nature - 1993 - Müller M - Briscoe J - Laxton C - Guschin D - Ziemiecki A - Silvennoinen O - Harpur AG - Barbieri G - Witthuhn BA - Schindler C - - - 9305869 + + 1280824 PubMed - Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. - J Biol Chem - 1997 - Burfoot MS - Rogers NC - Watling D - Smith JM - Pons S - Paonessaw G - Pellegrini S - White MF - Kerr IM + Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor. + Proc Natl Acad Sci U S A + 1992 + Gutch MJ + Daly C + Reich NC 9374471 @@ -1364,6 +1437,33 @@ Druker BJ Platanias LC + + 10022928 + PubMed + Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. + Mol Cell Biol + 1999 + You M + Yu DH + Feng GS + + + 8780698 + PubMed + Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase. + Biochem Biophys Res Commun + 1996 + Uddin S + Gardziola C + Dangat A + Yi T + Platanias LC + + + immune response pathway + PW:0000023 + Pathway Ontology + 9724754 PubMed @@ -1378,6 +1478,29 @@ Chang DD Shuai K + + 17968323 + PubMed + MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. + Oncogene + 2008 + Asangani IA + Rasheed SA + Nikolova DA + Leupold JH + Colburn NH + Post S + Allgayer H + + + 8496154 + PubMed + Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21. + J Biol Chem + 1993 + Colamonici OR + Domanski P + 7608146 PubMed @@ -1391,119 +1514,34 @@ White MF Platanias LC - - 9857039 - PubMed - The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. - J Biol Chem - 1998 - Song MM - Shuai K - - - 9196040 + + 9287210 PubMed - Interaction of p59fyn with interferon-activated Jak kinases. - Biochem Biophys Res Commun + STATs and gene regulation. + Science 1997 - Uddin S - Sher DA - Alsayed Y - Pons S - Colamonici OR - Fish EN - White MF - Platanias LC - - - 2153461 - PubMed - Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. - Cell - 1990 - Uzé G - Lutfalla G - Gresser I - - - 10022928 - PubMed - Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. - Mol Cell Biol - 1999 - You M - Yu DH - Feng GS - - - 8524272 - PubMed - Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. - Mol Cell Biol - 1995 - David M - Chen HE - Goelz S - Larner AC - Neel BG - - - 10644731 - PubMed - Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2. - J Biol Chem - 2000 - Farrar JD - Smith JD - Murphy TL - Murphy KM - - - 8628273 - PubMed - Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction. - Mol Cell Biol - 1996 - Yan H - Krishnan K - Lim JT - Contillo LG - Krolewski JJ - - - 8550573 - PubMed - The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. - J Biol Chem - 1996 - Platanias LC - Uddin S - Yetter A - Sun XJ - White MF + Darnell JE Jr - - 9295335 + + 17604604 PubMed - Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2. - J Biol Chem - 1997 - Owczarek CM - Hwang SY - Holland KA - Gulluyan LM - Tavaria M - Weaver B - Reich NC - Kola I - Hertzog PJ + Involvement of the Gab2 scaffolding adapter in type I interferon signalling. + Cell Signal + 2007 + Baychelier F + Nardeux PC + Cajean-Feroldi C + Ermonval M + Guymarho J + Tovey MG + Eid P - - 1468582 + + 8181059 PubMed - Soluble interferon-alpha receptor molecules are present in body fluids. - FEBS Lett - 1992 + The human interferon alpha/beta receptor: characterization and molecular cloning. + Cell + 1994 Novick D Cohen B Rubinstein M @@ -1523,24 +1561,17 @@ Owczarek CM Hertzog PJ - - 8181059 - PubMed - The human interferon alpha/beta receptor: characterization and molecular cloning. - Cell - 1994 - Novick D - Cohen B - Rubinstein M - - - 8496154 + + 1496401 PubMed - Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21. - J Biol Chem - 1993 - Colamonici OR - Domanski P + Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. + Science + 1992 + Schindler C + Shuai K + Prezioso VR + Darnell JE Jr + diff --git a/pathways/WP3213/WP3213.json b/pathways/WP3213/WP3213.json index 1bd71b3c2..c865578fc 100644 --- a/pathways/WP3213/WP3213.json +++ b/pathways/WP3213/WP3213.json @@ -1,5 +1,34 @@ { "entitiesById": { + "a0117": { + "contains": [ + "f251b", + "f1a3e" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 44, + "id": "a0117", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 104, + "x": 1015, + "y": 575, + "zIndex": 32768 + }, "a01e3": { "drawAs": "TrianglePathVisio", "fill": "transparent", @@ -42,7 +71,7 @@ "gpmlElementName": "Shape", "height": 16, "id": "a0b24", - 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"isPartOf": "cc13a", + "isPartOf": "aa6e2", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2256,13 +2405,10 @@ "y": 56.65000000000009, "zIndex": 32768 }, - "c07c3": { - "citations": [ - "publicationXrefe58" - ], + "bf741": { "contains": [ - "f94dd", - "a9fa8" + "f82b5", + "eb992" ], "drawAs": "none", "fill": "transparent", @@ -2270,8 +2416,8 @@ "fontSize": 1, "fontWeight": "bold", "gpmlElementName": "Group", - "height": 45, - "id": "c07c3", + "height": 44, + "id": "bf741", "kaavioType": "Group", "padding": 8, "stroke": "#808080", @@ -2283,9 +2429,9 @@ "GroupGroup" ], "verticalAlign": "middle", - "width": 106, - "x": 1107, - "y": 423, + "width": 105, + "x": 159, + "y": 689, "zIndex": 32768 }, "c0c7a": { @@ -2348,7 +2494,7 @@ "gpmlElementName": "Label", "height": 20, "id": "c1241", - "isPartOf": "cc13a", + "isPartOf": "aa6e2", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2370,35 +2516,6 @@ "y": 19.5, "zIndex": 28672 }, - "c1501": { - 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"c2c34": { - "contains": [ - "fba61", - "b1603" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 46.25, - "id": "c2c34", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 109.25, - "x": 1068.75, - "y": 531, - "zIndex": 32768 - }, "c35a8": { "comments": [ { "content": "in CD4(+) T-Cells" - }, - { - "content": "Type your comment here" } ], "drawAs": "rect", @@ -2577,7 +2662,7 @@ "gpmlElementName": "Shape", "height": 102, "id": "c35a8", - "isPartOf": "be254", + "isPartOf": "b49bd", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2633,6 +2718,35 @@ "y": 868.5893416927913, "zIndex": 16384 }, + "c46ee": { + "contains": [ + "fba61", + "b1603" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 46.25, + "id": "c46ee", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 109.25, + "x": 1068.75, + "y": 531, + "zIndex": 32768 + }, "c4c5e": { "drawAs": "none", "fill": "transparent", @@ -2664,72 +2778,6 @@ "y": 54.30093155123534, "zIndex": 32807 }, - "c5061": { - "contains": [ - "a4bdc", - "a465b", - "c2702", - "f2a8d", - "ef59a", - "a44d8" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 133, - "id": "c5061", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 276, - "x": 40, - "y": 208, - "zIndex": 16384 - }, - "c51ee": { - "contains": [ - "a51f3", - "aa6e3", - "bb451", - "d7a71", - "fc5e2", - "ffdd9" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 138.33333333333331, - "id": "c51ee", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 419.6670716889432, - "x": 577.9995949777235, - "y": 22, - "zIndex": 28672 - }, "c522c": { "backpageHead": "RAC1", "comments": [ @@ -2839,7 +2887,7 @@ "gpmlElementName": "Shape", "height": 65, "id": "c615a", - "isPartOf": "dad4e", + "isPartOf": "c89de", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2854,43 +2902,14 @@ "textOverflow": "clip", "type": [ "Shape", - "SingleFreeNode" - ], - "verticalAlign": "middle", - "whiteSpace": "pre", - "width": 92, - "x": 8, - "y": 8, - "zIndex": 16384 - }, - "c623d": { - "contains": [ - "c73c9", - "d44a2" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 43, - "id": "c623d", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 105, - "x": 1016, - "y": 479, - "zIndex": 32768 + "SingleFreeNode" + ], + "verticalAlign": "middle", + "whiteSpace": "pre", + "width": 92, + "x": 8, + "y": 8, + "zIndex": 16384 }, "c73c9": { "comments": [ @@ -2908,7 +2927,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c73c9", - "isPartOf": "c623d", + "isPartOf": "fef7c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2943,64 +2962,6 @@ "y": 15, "zIndex": 32768 }, - "c794b": { - "contains": [ - "af295", - "f10c6" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 76, - "id": "c794b", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 219, - "x": 609, - "y": 646, - "zIndex": 16384 - }, - "c7b83": { - "contains": [ - "eb6a9", - "a8a58" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 45, - "id": "c7b83", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 107, - "x": 1110, - "y": 476, - "zIndex": 32768 - }, "c7db9": { "drawAs": "Ellipse", "fill": "transparent", @@ -3033,6 +2994,36 @@ "y": 847.6175548589343, "zIndex": 16384 }, + "c89de": { + "contains": [ + "c615a", + "b3a43", + "ef5e6" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 81, + "id": "c89de", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 108, + "x": 914, + "y": 441, + "zIndex": 16384 + }, "c9a1b": { "drawAs": "Ellipse", "fill": "transparent", @@ -3084,7 +3075,7 @@ "gpmlElementName": "DataNode", "height": 21.48333333333335, "id": "ca195", - "isPartOf": "be254", + "isPartOf": "b49bd", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3126,7 +3117,7 @@ "gpmlElementName": "Shape", "height": 82, "id": "ca64d", - "isPartOf": "b2e91", + "isPartOf": "ce8ce", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3150,44 +3141,10 @@ "y": 32, "zIndex": 16384 }, - "cb44e": { - "contains": [ - "f251b", - "f1a3e" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 44, - "id": "cb44e", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 104, - "x": 1015, - "y": 575, - "zIndex": 32768 - }, - "cc13a": { + "cbd42": { "contains": [ - "b308c", - "c1241", - "bf354", - "d40f5", - "ffbf8", - "bc2ac", - "c193b" + "e051f", + "aa083" ], "drawAs": "none", "fill": "transparent", @@ -3195,8 +3152,8 @@ "fontSize": 1, "fontWeight": "bold", "gpmlElementName": "Group", - "height": 142.5, - "id": "cc13a", + "height": 163.44228432563784, + "id": "cbd42", "kaavioType": "Group", "padding": 8, "stroke": "#808080", @@ -3208,9 +3165,9 @@ "GroupGroup" ], "verticalAlign": "middle", - "width": 226.5, - "x": 698.5, - "y": 340.5, + "width": 290.1312272174978, + "x": 771.8687727825022, + "y": 11.02187120291623, "zIndex": 16384 }, "cd23e": { @@ -3289,8 +3246,11 @@ "GDP", "Wikidata:Q422582", "ChEBI:17552", - "ChEBI:17552", - "InChI:QGWNDRXFNXRZMB-UUOKFMHZSA-N" + "InChI:QGWNDRXFNXRZMB-UUOKFMHZSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3318,7 +3278,7 @@ "gpmlElementName": "DataNode", "height": 21.48333333333335, "id": "ce449", - "isPartOf": "cfbca", + "isPartOf": "aea74", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3352,11 +3312,10 @@ "y": 13.408333333333417, "zIndex": 32795 }, - "cfbca": { + "ce8ce": { "contains": [ - "f1bdc", - "ce449", - "f805b" + "ca64d", + "e6b42" ], "drawAs": "none", "fill": "transparent", @@ -3364,8 +3323,8 @@ "fontSize": 1, "fontWeight": "bold", "gpmlElementName": "Group", - "height": 85, - "id": "cfbca", + "height": 122, + "id": "ce8ce", "kaavioType": "Group", "padding": 8, "stroke": "#808080", @@ -3377,10 +3336,10 @@ "GroupGroup" ], "verticalAlign": "middle", - "width": 112, - "x": 899, - "y": 534, - "zIndex": 32794 + "width": 247, + "x": 58, + "y": 379, + "zIndex": 16384 }, "d1361": { "backpageHead": "CRKL", @@ -3440,7 +3399,7 @@ "gpmlElementName": "Label", "height": 20, "id": "d1d8a", - "isPartOf": "b110f", + "isPartOf": "e7327", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3472,7 +3431,7 @@ "gpmlElementName": "Shape", "height": 16, "id": "d25fd", - "isPartOf": "b110f", + "isPartOf": "e7327", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3561,7 +3520,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "d40f5", - "isPartOf": "cc13a", + "isPartOf": "aa6e2", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3649,7 +3608,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "d43d7", - "isPartOf": "c1501", + "isPartOf": "adf7b", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3691,7 +3650,7 @@ "gpmlElementName": "Shape", "height": 16, "id": "d44a2", - "isPartOf": "c623d", + "isPartOf": "fef7c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3714,35 +3673,6 @@ "y": 8, "zIndex": 32779 }, - "d6984": { - "contains": [ - "f3d7e", - "a0b24" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 46.150000000000034, - "id": "d6984", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 109.58750000000009, - "x": 1026.4125, - "y": 281, - "zIndex": 32768 - }, "d70c9": { "comments": [ { @@ -3759,7 +3689,7 @@ "gpmlElementName": "DataNode", "height": 21.48333333333335, "id": "d70c9", - "isPartOf": "be254", + "isPartOf": "b49bd", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3810,7 +3740,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "d7a71", - "isPartOf": "c51ee", + "isPartOf": "f762c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3847,9 +3777,6 @@ { "content": "AKT" }, - { - "content": "Type your comment here" - }, { "content": "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475", "source": "HomologyConvert" @@ -3901,36 +3828,6 @@ "y": 368.1500000000001, "zIndex": 32768 }, - "dad4e": { - "contains": [ - "c615a", - "b3a43", - "ef5e6" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 81, - "id": "dad4e", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 108, - "x": 914, - "y": 441, - "zIndex": 16384 - }, "dc4c7": { "drawAs": "Ellipse", "fill": "#ff0000", @@ -4057,35 +3954,6 @@ "y": 671.25, "zIndex": 32768 }, - "dd352": { - "contains": [ - "e051f", - "aa083" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 163.44228432563784, - "id": "dd352", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 290.1312272174978, - "x": 771.8687727825022, - "y": 11.02187120291623, - "zIndex": 16384 - }, "dd379": { "drawAs": "Ellipse", "fill": "#ff0000", @@ -4096,7 +3964,7 @@ "gpmlElementName": "Shape", "height": 16, "id": "dd379", - "isPartOf": "c1501", + "isPartOf": "adf7b", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4177,7 +4045,7 @@ "gpmlElementName": "Shape", "height": 147.44228432563784, "id": "e051f", - "isPartOf": "dd352", + "isPartOf": "cbd42", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4211,7 +4079,7 @@ "gpmlElementName": "Shape", "height": 16, "id": "e105c", - "isPartOf": "b110f", + "isPartOf": "e7327", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4281,6 +4149,39 @@ "y": 812, "zIndex": 32768 }, + "e1bde": { + "contains": [ + "a4bdc", + "a465b", + "c2702", + "f2a8d", + "ef59a", + "a44d8" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 133, + "id": "e1bde", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 276, + "x": 40, + "y": 208, + "zIndex": 16384 + }, "e374a": { "comments": [ { @@ -4297,7 +4198,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e374a", - "isPartOf": "b7070", + "isPartOf": "ffa8d", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4467,7 +4368,7 @@ "gpmlElementName": "Label", "height": 20, "id": "e6b42", - "isPartOf": "b2e91", + "isPartOf": "ce8ce", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4489,6 +4390,39 @@ "y": 8, "zIndex": 28672 }, + "e7327": { + "contains": [ + "bd9ac", + "d1d8a", + "bd249", + "fe0a6", + "e105c", + "d25fd" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 126, + "id": "e7327", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 193, + "x": 499, + "y": 388, + "zIndex": 16384 + }, "e891e": { "comments": [ { @@ -4549,7 +4483,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "eb6a9", - "isPartOf": "c7b83", + "isPartOf": "b5388", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4593,7 +4527,7 @@ "gpmlElementName": "Shape", "height": 16, "id": "eb992", - "isPartOf": "b9ff7", + "isPartOf": "bf741", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4632,7 +4566,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "ec3f4", - "isPartOf": "be254", + "isPartOf": "b49bd", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4809,7 +4743,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "ef59a", - "isPartOf": "c5061", + "isPartOf": "e1bde", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4849,7 +4783,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "ef5e6", - "isPartOf": "dad4e", + "isPartOf": "c89de", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4881,35 +4815,6 @@ "y": 45, "zIndex": 32770 }, - "f0bb7": { - "contains": [ - "a6dbc", - "b5d0c" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 42, - "id": "f0bb7", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 104, - "x": 192, - "y": 517, - "zIndex": 32768 - }, "f0eec": { "drawAs": "Ellipse", "fill": "#ff0000", @@ -4920,7 +4825,7 @@ "gpmlElementName": "Shape", "height": 16, "id": "f0eec", - "isPartOf": "b7070", + "isPartOf": "ffa8d", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4953,7 +4858,7 @@ "gpmlElementName": "Label", "height": 20, "id": "f10c6", - "isPartOf": "c794b", + "isPartOf": "be8ea", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5035,7 +4940,7 @@ "gpmlElementName": "Shape", "height": 16, "id": "f1a3e", - "isPartOf": "cb44e", + "isPartOf": "a0117", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5068,7 +4973,7 @@ "gpmlElementName": "Shape", "height": 16, "id": "f1a80", - "isPartOf": "f4a3f", + "isPartOf": "f60e4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5101,7 +5006,7 @@ "gpmlElementName": "Shape", "height": 69, "id": "f1bdc", - "isPartOf": "cfbca", + "isPartOf": "aea74", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5173,7 +5078,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f251b", - "isPartOf": "cb44e", + "isPartOf": "a0117", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5223,7 +5128,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f2a8d", - "isPartOf": "c5061", + "isPartOf": "e1bde", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5273,7 +5178,7 @@ "gpmlElementName": "DataNode", "height": 21.48333333333335, "id": "f3d7e", - "isPartOf": "d6984", + "isPartOf": "a4831", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5306,7 +5211,39 @@ "y": 16.666666666666686, "zIndex": 32768 }, - "f4a3f": { + "f5178": { + "drawAs": "none", + "fill": "transparent", + "fontFamily": "Arial", + "fontSize": 12, + "fontStyle": "normal", + "fontWeight": "bold", + "gpmlElementName": "Label", + "height": 20, + "id": "f5178", + "isPartOf": "b9a31", + "kaavioType": "SingleFreeNode", + "lineHeight": 1.1, + "overflow": "hidden", + "padding": 8, + "stroke": "#000000", + "strokeWidth": 0, + "textAlign": "center", + "textContent": "Interferon Stimulated Response Element", + "textDecoration": "none", + "textOverflow": "clip", + "type": [ + "Label", + "SingleFreeNode" + ], + "verticalAlign": "middle", + "whiteSpace": "pre", + "width": 280, + "x": 8, + "y": 53.05617087818075, + "zIndex": 28672 + }, + "f60e4": { "contains": [ "b14c8", "f1a80" @@ -5318,7 +5255,7 @@ "fontWeight": "bold", "gpmlElementName": "Group", "height": 46, - "id": "f4a3f", + "id": "f60e4", "kaavioType": "Group", "padding": 8, "stroke": "#808080", @@ -5335,36 +5272,37 @@ "y": 570, "zIndex": 32768 }, - "f5178": { + "f762c": { + "contains": [ + "a51f3", + "aa6e3", + "bb451", + "d7a71", + "fc5e2", + "ffdd9" + ], "drawAs": "none", "fill": "transparent", - "fontFamily": "Arial", - "fontSize": 12, - "fontStyle": "normal", + "fillOpacity": 0.1, + "fontSize": 1, "fontWeight": "bold", - "gpmlElementName": "Label", - "height": 20, - "id": "f5178", - "isPartOf": "a9ad1", - "kaavioType": "SingleFreeNode", - "lineHeight": 1.1, - "overflow": "hidden", + "gpmlElementName": "Group", + "height": 138.33333333333331, + "id": "f762c", + "kaavioType": "Group", "padding": 8, - "stroke": "#000000", + "stroke": "#808080", + "strokeDasharray": "5,3", "strokeWidth": 0, "textAlign": "center", - "textContent": "Interferon Stimulated Response Element", - "textDecoration": "none", - "textOverflow": "clip", "type": [ - "Label", - "SingleFreeNode" + "Group", + "GroupGroup" ], "verticalAlign": "middle", - "whiteSpace": "pre", - "width": 280, - "x": 8, - "y": 53.05617087818075, + "width": 419.6670716889432, + "x": 577.9995949777235, + "y": 22, "zIndex": 28672 }, "f805b": { @@ -5384,7 +5322,7 @@ "gpmlElementName": "DataNode", "height": 21.48333333333335, "id": "f805b", - "isPartOf": "cfbca", + "isPartOf": "aea74", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5432,7 +5370,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f82b5", - "isPartOf": "b9ff7", + "isPartOf": "bf741", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5479,7 +5417,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f94dd", - "isPartOf": "c07c3", + "isPartOf": "aa703", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5609,7 +5547,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "fba61", - "isPartOf": "c2c34", + "isPartOf": "c46ee", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5699,7 +5637,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "fc5e2", - "isPartOf": "c51ee", + "isPartOf": "f762c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5747,7 +5685,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "fe0a6", - "isPartOf": "b110f", + "isPartOf": "e7327", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5813,6 +5751,64 @@ "y": 399, "zIndex": 32802 }, + "fef7c": { + "contains": [ + "c73c9", + "d44a2" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 43, + "id": "fef7c", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 105, + "x": 1016, + "y": 479, + "zIndex": 32768 + }, + "ffa8d": { + "contains": [ + "e374a", + "f0eec" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 43.75, + "id": "ffa8d", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 107.25, + "x": 958.75, + "y": 676, + "zIndex": 32768 + }, "ffbf8": { "comments": [ { @@ -5829,7 +5825,7 @@ "gpmlElementName": "DataNode", "height": 21.48333333333335, "id": "ffbf8", - "isPartOf": "cc13a", + "isPartOf": "aa6e2", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5887,7 +5883,7 @@ "gpmlElementName": "DataNode", "height": 34, "id": "ffdd9", - "isPartOf": "c51ee", + "isPartOf": "f762c", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5962,7 +5958,6 @@ 1 ] }, - "id": "f8836", "isAttachedTo": "ca195", "orientation": [ 0, @@ -5982,7 +5977,6 @@ 0 ] }, - "id": "b17fb", "isAttachedTo": "d70c9", "orientation": [ 0, @@ -6023,7 +6017,6 @@ 1 ] }, - "id": "f8a94", "isAttachedTo": "a4bdc", "orientation": [ 0, @@ -6043,7 +6036,6 @@ 0 ] }, - "id": "fc00e", "isAttachedTo": "d8e9b", "orientation": [ 0, @@ -6084,7 +6076,6 @@ 1 ] }, - "id": "ef996", "isAttachedTo": "f251b", "orientation": [ 0, @@ -6108,7 +6099,6 @@ 0 ] }, - "id": "c7618", "isAttachedTo": "e374a", "orientation": [ 0, @@ -6136,7 +6126,7 @@ "beb0d" ], "kaavioType": "Edge", - "markerEnd": "MimInhibition", + "markerEnd": "TBar", "points": [ { "attachmentDisplay": { @@ -6149,7 +6139,6 @@ 0 ] }, - "id": "a6e68", "isAttachedTo": "ae8d9", "orientation": [ 0, @@ -6173,7 +6162,6 @@ 1 ] }, - "id": "ef7ad", "isAttachedTo": "beb0d", "orientation": [ 0, @@ -6187,7 +6175,9 @@ "strokeWidth": 2, "type": [ "Interaction", - "Edge" + "Edge", + "SBO:0000169", + "Inhibition" ], "zIndex": 12288 }, @@ -6214,7 +6204,6 @@ 1 ] }, - "id": "cc3a7", "isAttachedTo": "f2a8d", "orientation": [ 0, @@ -6234,7 +6223,6 @@ 0 ] }, - "id": "a5824", "isAttachedTo": "c2702", "orientation": [ 0, @@ -6279,7 +6267,6 @@ 1 ] }, - "id": "e362d", "isAttachedTo": "d1361", "orientation": [ 0, @@ -6299,7 +6286,6 @@ 0 ] }, - "id": "cbcd8", "isAttachedTo": "e5d51", "orientation": [ 0, @@ -6344,7 +6330,6 @@ 1 ] }, - "id": "a760b", "isAttachedTo": "e051f", "orientation": [ 0, @@ -6364,7 +6349,6 @@ 0 ] }, - "id": "ad03d", "isAttachedTo": "b3a43", "orientation": [ 0, @@ -6405,7 +6389,6 @@ 1 ] }, - "id": "c4f28", "isAttachedTo": "a5e45", "orientation": [ 0, @@ -6429,7 +6412,6 @@ 0 ] }, - "id": "f0582", "isAttachedTo": "ac8c7", "orientation": [ 0, @@ -6470,7 +6452,6 @@ 0.5 ] }, - "id": "b088e", "isAttachedTo": "f2a8d", "orientation": [ 1, @@ -6490,7 +6471,6 @@ 0.5 ] }, - "id": "ffe84", "isAttachedTo": "ef59a", "orientation": [ 1, @@ -6535,7 +6515,6 @@ 1 ] }, - "id": "bc73d", "isAttachedTo": "f94dd", "orientation": [ 0, @@ -6555,7 +6534,6 @@ 0 ] }, - "id": "fb5a7", "isAttachedTo": "eb6a9", "orientation": [ 0, @@ -6596,7 +6574,6 @@ 1 ] }, - "id": "e2583", "isAttachedTo": "b3698", "orientation": [ 0, @@ -6620,7 +6597,6 @@ 0 ] }, - "id": "cfc79", "isAttachedTo": "dcf74", "orientation": [ 0, @@ -6661,7 +6637,6 @@ 1 ] }, - "id": "a8d7c", "isAttachedTo": "dcf74", "orientation": [ 0, @@ -6681,7 +6656,6 @@ 0.25 ] }, - "id": "c8297", "isAttachedTo": "c7db9", "orientation": [ -1, @@ -6726,7 +6700,6 @@ 1 ] }, - "id": "d784b", "isAttachedTo": "a63d7", "orientation": [ 0, @@ -6736,7 +6709,6 @@ "y": 532.15 }, { - "id": "dadb7", "x": 1303.4125, "y": 590.9090909090909 }, @@ -6751,7 +6723,6 @@ 0 ] }, - "id": "c3154", "isAttachedTo": "ef3c1", "orientation": [ 0, @@ -6780,7 +6751,7 @@ "id": "id3bfa8b3", "isAttachedTo": [ "bb451", - "dd352" + "cbd42" ], "kaavioType": "Edge", "markerEnd": "Arrow", @@ -6796,7 +6767,6 @@ 0.5 ] }, - "id": "f954f", "isAttachedTo": "bb451", "orientation": [ -1, @@ -6816,8 +6786,7 @@ 0.75 ] }, - "id": "d3298", - "isAttachedTo": "dd352", + "isAttachedTo": "cbd42", "orientation": [ 1, 0 @@ -6862,7 +6831,6 @@ 1 ] }, - "id": "f1edb", "isAttachedTo": "ef59a", "orientation": [ 0, @@ -6882,7 +6850,6 @@ 0 ] }, - "id": "fc485", "isAttachedTo": "c2702", "orientation": [ 0, @@ -6927,7 +6894,6 @@ 1 ] }, - "id": "d2c6d", "isAttachedTo": "ad5f8", "orientation": [ 0, @@ -6947,7 +6913,6 @@ 0.25 ] }, - "id": "b5c37", "isAttachedTo": "c7db9", "orientation": [ 1, @@ -6992,7 +6957,6 @@ 0 ] }, - "id": "e4ab0", "isAttachedTo": "f1bdc", "orientation": [ 0, @@ -7016,7 +6980,6 @@ 0 ] }, - "id": "a7b4d", "isAttachedTo": "af295", "orientation": [ 0, @@ -7057,7 +7020,6 @@ 1 ] }, - "id": "a4572", "isAttachedTo": "ce449", "orientation": [ 0, @@ -7077,7 +7039,6 @@ 0 ] }, - "id": "c686e", "isAttachedTo": "f805b", "orientation": [ 0, @@ -7118,7 +7079,6 @@ 1 ] }, - "id": "de6f4", "isAttachedTo": "bb451", "orientation": [ 0, @@ -7142,7 +7102,6 @@ 0 ] }, - "id": "b486c", "isAttachedTo": "a4afa", "orientation": [ 0, @@ -7183,7 +7142,6 @@ 0 ] }, - "id": "a4636", "isAttachedTo": "aa6e3", "orientation": [ 0, @@ -7203,7 +7161,6 @@ 1 ] }, - "id": "f6eaf", "isAttachedTo": "ffdd9", "orientation": [ 0, @@ -7228,7 +7185,7 @@ "id": "id4d1c3d1e", "isAttachedTo": [ "b6e09", - "c51ee" + "f762c" ], "kaavioType": "Edge", "markerEnd": "MimInhibition", @@ -7244,7 +7201,6 @@ 0 ] }, - "id": "e492d", "isAttachedTo": "b6e09", "orientation": [ 0, @@ -7268,8 +7224,7 @@ 1 ] }, - "id": "abee5", - "isAttachedTo": "c51ee", + "isAttachedTo": "f762c", "orientation": [ 0, -1 @@ -7309,7 +7264,6 @@ 1 ] }, - "id": "ad6f4", "isAttachedTo": "c73c9", "orientation": [ 0, @@ -7333,7 +7287,6 @@ 0 ] }, - "id": "e88e9", "isAttachedTo": "fba61", "orientation": [ 0, @@ -7374,7 +7327,6 @@ 0.75 ] }, - "id": "bf988", "isAttachedTo": "ffdd9", "orientation": [ 1, @@ -7384,7 +7336,6 @@ "y": 103.5 }, { - "id": "da1a8", "x": 1004.7021943573668, "y": 122.82500000000005 }, @@ -7399,7 +7350,6 @@ 0.5 ] }, - "id": "c01e8", "isAttachedTo": "a721a", "orientation": [ 1, @@ -7445,7 +7395,6 @@ 1 ] }, - "id": "b8e03", "isAttachedTo": "f3d7e", "orientation": [ 0, @@ -7469,7 +7418,6 @@ 0 ] }, - "id": "d1755", "isAttachedTo": "c522c", "orientation": [ 0, @@ -7510,7 +7458,6 @@ 0 ] }, - "id": "ab57c", "isAttachedTo": "fba61", "orientation": [ 0, @@ -7534,7 +7481,6 @@ 0 ] }, - "id": "bd59f", "isAttachedTo": "d43d7", "orientation": [ 0, @@ -7575,7 +7521,6 @@ 1 ] }, - "id": "b704c", "isAttachedTo": "bf354", "orientation": [ 0, @@ -7595,7 +7540,6 @@ 0 ] }, - "id": "c0ccb", "isAttachedTo": "d40f5", "orientation": [ 0, @@ -7636,7 +7580,6 @@ 1 ] }, - "id": "e06af", "isAttachedTo": "c0c7a", "orientation": [ 0, @@ -7656,7 +7599,6 @@ 0 ] }, - "id": "c68e3", "isAttachedTo": "dcf74", "orientation": [ 0, @@ -7701,7 +7643,6 @@ 1 ] }, - "id": "b4669", "isAttachedTo": "b14c8", "orientation": [ 0, @@ -7725,7 +7666,6 @@ 0 ] }, - "id": "a01f5", "isAttachedTo": "ad5f8", "orientation": [ 0, @@ -7766,7 +7706,6 @@ 1 ] }, - "id": "dfc8f", "isAttachedTo": "ffbf8", "orientation": [ 0, @@ -7786,7 +7725,6 @@ 0 ] }, - "id": "a5c1d", "isAttachedTo": "bf354", "orientation": [ 0, @@ -7827,7 +7765,6 @@ 1 ] }, - "id": "f5658", "isAttachedTo": "e051f", "orientation": [ 0, @@ -7851,7 +7788,6 @@ 0 ] }, - "id": "a0284", "isAttachedTo": "ce449", "orientation": [ 0, @@ -7896,7 +7832,6 @@ 1 ] }, - "id": "d2dc0", "isAttachedTo": "d43d7", "orientation": [ 0, @@ -7920,7 +7855,6 @@ 0 ] }, - "id": "c7bd6", "isAttachedTo": "e374a", "orientation": [ 0, @@ -7961,7 +7895,6 @@ 1 ] }, - "id": "dcce8", "isAttachedTo": "e374a", "orientation": [ 0, @@ -7985,7 +7918,6 @@ 0 ] }, - "id": "b8974", "isAttachedTo": "c3b0a", "orientation": [ 0, @@ -8026,7 +7958,6 @@ 1 ] }, - "id": "daf9d", "isAttachedTo": "a74bc", "orientation": [ 0, @@ -8046,7 +7977,6 @@ 0 ] }, - "id": "b5c2e", "isAttachedTo": "b6986", "orientation": [ 0, @@ -8087,7 +8017,6 @@ 1 ] }, - "id": "c9dc9", "isAttachedTo": "d7a71", "orientation": [ 0, @@ -8097,7 +8026,6 @@ "y": 152.33333333333331 }, { - "id": "ad354", "x": 638.9781250000001, "y": 328.36990595611286 }, @@ -8112,7 +8040,6 @@ 0 ] }, - "id": "abd46", "isAttachedTo": "ca195", "orientation": [ 0, @@ -8136,7 +8063,7 @@ "gpmlElementName": "Interaction", "id": "id6fd15056", "isAttachedTo": [ - "be254", + "b49bd", "b10a2" ], "kaavioType": "Edge", @@ -8153,8 +8080,7 @@ 1 ] }, - "id": "c2567", - "isAttachedTo": "be254", + "isAttachedTo": "b49bd", "orientation": [ 0, 1 @@ -8177,7 +8103,6 @@ 1 ] }, - "id": "c504a", "isAttachedTo": "b10a2", "orientation": [ 0, @@ -8218,7 +8143,6 @@ 0.5 ] }, - "id": "a9cd5", "isAttachedTo": "b1dd1", "orientation": [ -1, @@ -8238,7 +8162,6 @@ 0 ] }, - "id": "fe565", "isAttachedTo": "f2a8d", "orientation": [ 0, @@ -8279,7 +8202,6 @@ 0.5 ] }, - "id": "ea6e0", "isAttachedTo": "ffdd9", "orientation": [ -1, @@ -8299,7 +8221,6 @@ 0.5 ] }, - "id": "c95ce", "isAttachedTo": "bb451", "orientation": [ -1, @@ -8340,7 +8261,6 @@ 1 ] }, - "id": "a7445", "isAttachedTo": "d8e9b", "orientation": [ 0, @@ -8360,7 +8280,6 @@ 0 ] }, - "id": "f77cc", "isAttachedTo": "ca64d", "orientation": [ 0, @@ -8401,7 +8320,6 @@ 1 ] }, - "id": "b35af", "isAttachedTo": "ca64d", "orientation": [ 0, @@ -8425,7 +8343,6 @@ 0 ] }, - "id": "a2077", "isAttachedTo": "b14c8", "orientation": [ 0, @@ -8466,7 +8383,6 @@ 0.5 ] }, - "id": "e238b", "isAttachedTo": "df049", "orientation": [ 1, @@ -8486,7 +8402,6 @@ 0.5 ] }, - "id": "a017a", "isAttachedTo": "cd23e", "orientation": [ 1, @@ -8527,7 +8442,6 @@ 1 ] }, - "id": "e30eb", "isAttachedTo": "fc5e2", "orientation": [ 0, @@ -8547,7 +8461,6 @@ 0.25 ] }, - "id": "fc249", "isAttachedTo": "bb451", "orientation": [ -1, @@ -8588,7 +8501,6 @@ 1 ] }, - "id": "d25b9", "isAttachedTo": "ac8c7", "orientation": [ 0, @@ -8612,7 +8524,6 @@ 0 ] }, - "id": "ebc25", "isAttachedTo": "a63d7", "orientation": [ 0, @@ -8636,7 +8547,7 @@ "gpmlElementName": "Interaction", "id": "id8b698ce6", "isAttachedTo": [ - "dad4e", + "c89de", "af295" ], "kaavioType": "Edge", @@ -8653,8 +8564,7 @@ 1 ] }, - "id": "ebaca", - "isAttachedTo": "dad4e", + "isAttachedTo": "c89de", "orientation": [ 0, 1 @@ -8677,7 +8587,6 @@ 0 ] }, - "id": "ecec9", "isAttachedTo": "af295", "orientation": [ 0, @@ -8718,7 +8627,6 @@ 0.75 ] }, - "id": "b8714", "isAttachedTo": "e051f", "orientation": [ -1, @@ -8742,7 +8650,6 @@ 0.5 ] }, - "id": "e1d0a", "isAttachedTo": "cd23e", "orientation": [ -1, @@ -8787,7 +8694,6 @@ 0 ] }, - "id": "f0063", "isAttachedTo": "e891e", "orientation": [ 0, @@ -8797,7 +8703,6 @@ "y": 158.75548589341682 }, { - "id": "d6f1b", "x": 723.9880094043885, "y": 136.36363636363637 }, @@ -8812,7 +8717,6 @@ 1 ] }, - "id": "a1833", "isAttachedTo": "bb451", "orientation": [ 0, @@ -8853,7 +8757,6 @@ 1 ] }, - "id": "bbcc5", "isAttachedTo": "f94dd", "orientation": [ 0, @@ -8877,7 +8780,6 @@ 0 ] }, - "id": "a98c7", "isAttachedTo": "c73c9", "orientation": [ 0, @@ -8905,7 +8807,7 @@ "b6986" ], "kaavioType": "Edge", - "markerEnd": "MimConversion", + "markerEnd": "MimModification", "points": [ { "attachmentDisplay": { @@ -8918,7 +8820,6 @@ 0.5 ] }, - "id": "ca9dd", "isAttachedTo": "c522c", "orientation": [ 1, @@ -8938,7 +8839,6 @@ 0.5 ] }, - "id": "ca3fc", "isAttachedTo": "b6986", "orientation": [ 1, @@ -8979,7 +8879,6 @@ 1 ] }, - "id": "b3917", "isAttachedTo": "b6986", "orientation": [ 0, @@ -8999,7 +8898,6 @@ 0 ] }, - "id": "b057d", "isAttachedTo": "f94dd", "orientation": [ 0, @@ -9040,7 +8938,6 @@ 0.5 ] }, - "id": "e0e06", "isAttachedTo": "c5757", "orientation": [ -1, @@ -9064,7 +8961,6 @@ 0.5 ] }, - "id": "cef0c", "isAttachedTo": "aa6e3", "orientation": [ -1, @@ -9105,7 +9001,6 @@ 1 ] }, - "id": "eb1f9", "isAttachedTo": "ca64d", "orientation": [ 0, @@ -9125,7 +9020,6 @@ 0 ] }, - "id": "a8824", "isAttachedTo": "a6dbc", "orientation": [ 0, @@ -9166,7 +9060,6 @@ 1 ] }, - "id": "b6264", "isAttachedTo": "b3a43", "orientation": [ 0, @@ -9186,7 +9079,6 @@ 0 ] }, - "id": "d9b28", "isAttachedTo": "ef5e6", "orientation": [ 0, @@ -9214,7 +9106,7 @@ "b10a2" ], "kaavioType": "Edge", - "markerEnd": "MimConversion", + "markerEnd": "MimModification", "points": [ { "attachmentDisplay": { @@ -9227,7 +9119,6 @@ 1 ] }, - 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"id": "fcd72", "isAttachedTo": "b308c", "orientation": [ 0, @@ -10511,7 +10360,6 @@ 0 ] }, - "id": "e5615", "isAttachedTo": "fba61", "orientation": [ 0, @@ -10535,7 +10383,6 @@ 0 ] }, - "id": "dba45", "isAttachedTo": "f251b", "orientation": [ 0, @@ -10576,7 +10423,6 @@ 1 ] }, - "id": "deafb", "isAttachedTo": "bd249", "orientation": [ 0, @@ -10600,7 +10446,6 @@ 0 ] }, - "id": "fedd0", "isAttachedTo": "af295", "orientation": [ 0, @@ -10641,7 +10486,6 @@ 1 ] }, - "id": "f1dd1", "isAttachedTo": "ef3c1", "orientation": [ 0, @@ -10651,7 +10495,6 @@ "y": 677.15 }, { - "id": "e825b", "x": 1199.95625, "y": 724.1379310344828 }, @@ -10666,7 +10509,6 @@ 0 ] }, - "id": "d69d4", "isAttachedTo": "af46d", "orientation": [ 0, @@ -10707,7 +10549,6 @@ 1 ] }, - "id": "ad182", "isAttachedTo": "d40f5", "orientation": [ 0, @@ -10731,7 +10572,6 @@ 0 ] }, - "id": "cb07a", "isAttachedTo": "af295", "orientation": [ 0, @@ -10772,7 +10612,6 @@ 1 ] }, - "id": "ebc6a", "isAttachedTo": "a6dbc", "orientation": [ 0, @@ -10796,7 +10635,6 @@ 0 ] }, - "id": "b31f5", "isAttachedTo": "b3698", "orientation": [ 0, @@ -10837,7 +10675,6 @@ 1 ] }, - "id": "ec481", "isAttachedTo": "fe0a6", "orientation": [ 0, @@ -10857,7 +10694,6 @@ 0 ] }, - "id": "bd845", "isAttachedTo": "bd249", "orientation": [ 0, @@ -10898,7 +10734,6 @@ 1 ] }, - "id": "e19e9", "isAttachedTo": "a5e45", "orientation": [ 0, @@ -10922,7 +10757,6 @@ 0 ] }, - "id": "e74f2", "isAttachedTo": "ba328", "orientation": [ 0, @@ -10950,7 +10784,7 @@ "d7a71" ], "kaavioType": "Edge", - "markerEnd": "MimInhibition", + "markerEnd": "TBar", "points": [ { "attachmentDisplay": { @@ -10963,7 +10797,6 @@ 0 ] }, - "id": "e55b5", "isAttachedTo": "b66bb", "orientation": [ 0, @@ -10983,7 +10816,6 @@ 0.5 ] }, - "id": "ec326", "isAttachedTo": "d7a71", "orientation": [ -1, @@ -10997,7 +10829,9 @@ "strokeWidth": 2, "type": [ "Interaction", - "Edge" + "Edge", + "SBO:0000169", + "Inhibition" ], "zIndex": 12288 }, @@ -11014,7 +10848,7 @@ "id": "publicationXrefa05", "source": "J Biol Chem", "standardName": "Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase.", - "textContent": "11", + "textContent": "12", "type": [ "PublicationXref", "PubMed:7608146" @@ -11039,7 +10873,7 @@ "id": "publicationXrefa13", "source": "Blood", "standardName": "The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-alpha receptors.", - "textContent": "16", + "textContent": "19", "type": [ "PublicationXref", "PubMed:9326223" @@ -11074,6 +10908,29 @@ "xrefIdentifier": "10428508", "year": 1999 }, + "publicationXrefa41": { + "authors": [ + "Asangani IA", + "Rasheed SA", + "Nikolova DA", + "Leupold JH", + "Colburn NH", + "Post S", + "Allgayer H" + ], + "gpmlElementName": "PublicationXref", + "id": "publicationXrefa41", + "source": "Oncogene", + "standardName": "MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer.", + "textContent": "30", + "type": [ + "PublicationXref", + "PubMed:17968323" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "17968323", + "year": 2008 + }, "publicationXrefa72": { "authors": [ "Owczarek CM", @@ -11090,7 +10947,7 @@ "id": "publicationXrefa72", "source": "J Biol Chem", "standardName": "Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2.", - "textContent": "21", + "textContent": "18", "type": [ "PublicationXref", "PubMed:9295335" @@ -11110,7 +10967,7 @@ "id": "publicationXrefa83", "source": "Science", "standardName": "Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.", - "textContent": "3", + "textContent": "5", "type": [ "PublicationXref", "PubMed:1496401" @@ -11131,7 +10988,7 @@ "id": "publicationXrefaa4", "source": "Mol Cell Biol", "standardName": "Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction.", - "textContent": "14", + "textContent": "13", "type": [ "PublicationXref", "PubMed:8628273" @@ -11151,7 +11008,7 @@ "id": "publicationXrefaf6", "source": "J Biol Chem", "standardName": "The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein.", - "textContent": "19", + "textContent": "20", "type": [ "PublicationXref", "PubMed:9374471" @@ -11168,7 +11025,7 @@ "id": "publicationXrefb16", "source": "Science", "standardName": "STATs and gene regulation.", - "textContent": "17", + "textContent": "21", "type": [ "PublicationXref", "PubMed:9287210" @@ -11192,7 +11049,7 @@ "id": "publicationXrefb20", "source": "Biochem Biophys Res Commun", "standardName": "Interaction of p59fyn with interferon-activated Jak kinases.", - "textContent": "20", + "textContent": "16", "type": [ "PublicationXref", "PubMed:9196040" @@ -11234,7 +11091,7 @@ "id": "publicationXrefb3e", "source": "J Biol Chem", "standardName": "Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling.", - "textContent": "10", + "textContent": "11", "type": [ "PublicationXref", "PubMed:7665574" @@ -11273,7 +11130,7 @@ "id": "publicationXrefc02", "source": "Mol Cell Biol", "standardName": "Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1.", - "textContent": "12", + "textContent": "10", "type": [ "PublicationXref", "PubMed:8524272" @@ -11291,7 +11148,7 @@ "id": "publicationXrefc1f", "source": "J Biol Chem", "standardName": "The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities.", - "textContent": "23", + "textContent": "22", "type": [ "PublicationXref", "PubMed:9857039" @@ -11335,7 +11192,7 @@ "id": "publicationXrefc8a", "source": "J Biol Chem", "standardName": "The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2.", - "textContent": "15", + "textContent": "14", "type": [ "PublicationXref", "PubMed:8550573" @@ -11357,7 +11214,7 @@ "id": "publicationXrefc9b", "source": "J Biol Chem", "standardName": "Activation of a CrkL-stat5 signaling complex by type I interferons.", - "textContent": "25", + "textContent": "24", "type": [ "PublicationXref", "PubMed:9872990" @@ -11396,7 +11253,7 @@ "id": "publicationXrefcbf", "source": "FEBS Lett", "standardName": "Soluble interferon-alpha receptor molecules are present in body fluids.", - "textContent": "5", + "textContent": "2", "type": [ "PublicationXref", "PubMed:1468582" @@ -11417,7 +11274,7 @@ "id": "publicationXrefcf0", "source": "Biochem Biophys Res Commun", "standardName": "Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase.", - "textContent": "13", + "textContent": "15", "type": [ "PublicationXref", "PubMed:8780698" @@ -11434,7 +11291,7 @@ "id": "publicationXrefd08", "source": "Cell", "standardName": "A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s).", - "textContent": "2", + "textContent": "3", "type": [ "PublicationXref", "PubMed:1638633" @@ -11477,7 +11334,7 @@ "id": "publicationXrefe15", "source": "J Immunol", "standardName": "Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock.", - "textContent": "30", + "textContent": "32", "type": [ "PublicationXref", "PubMed:24696235" @@ -11486,6 +11343,34 @@ "xrefIdentifier": "24696235", "year": 2014 }, + "publicationXrefe1c": { + "authors": [ + "Liu X", + "Zhang Z", + "Sun L", + "Chai N", + "Tang S", + "Jin J", + "Hu H", + "Nie Y", + "Wang X", + "Wu K", + "Jin H", + "Fan D" + ], + "gpmlElementName": "PublicationXref", + "id": "publicationXrefe1c", + "source": "Carcinogenesis", + "standardName": "MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4.", + "textContent": "31", + "type": [ + "PublicationXref", + "PubMed:21934092" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "21934092", + "year": 2011 + }, "publicationXrefe58": { "authors": [ "Uddin S", @@ -11502,7 +11387,7 @@ "id": "publicationXrefe58", "source": "J Biol Chem", "standardName": "Activation of the p38 mitogen-activated protein kinase by type I interferons.", - "textContent": "24", + "textContent": "25", "type": [ "PublicationXref", "PubMed:10514501" @@ -11553,7 +11438,7 @@ "id": "publicationXrefeba", "source": "J Biol Chem", "standardName": "Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons.", - "textContent": "18", + "textContent": "17", "type": [ "PublicationXref", "PubMed:9305869" @@ -11637,7 +11522,7 @@ "id": "publicationXrefffc", "source": "Proc Natl Acad Sci U S A", "standardName": "Inhibition of Stat1-mediated gene activation by PIAS1.", - "textContent": "22", + "textContent": "23", "type": [ "PublicationXref", "PubMed:9724754" @@ -11651,7 +11536,7 @@ "@context": [ "https://cdn.rawgit.com/wikipathways/WpVocabularies/7a46a05/contexts/pvjs.jsonld", { - "@base": "http://identifiers.org/wikipathways/WP3213/" + "@base": "WP3213/" } ], "author": "[Mkutmon, Egonw, MaintBot]", @@ -11660,9 +11545,6 @@ "content": "The type I IFNs (IFNα family, IFNβ, IFNω, IFNε and IFNκ) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other accessory proteins. The pathway above (WP585) describes the Type I Interferon signaling pathways and shows both classical IFN signaling via the JAK-STAT pathway (dark lines) and other non-canonical IFN signaling pathways.", "source": "WikiPathways-description" }, - { - "content": "Type your comment here" - }, { "content": "This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP585_r80201 WP585(80201)] with a 95.0% conversion rate.", "source": "HomologyConvert" @@ -11756,18 +11638,18 @@ "c7db9", "c9a1b", "fba6c", - "cc13a", - "be254", - "a9ad1", - "c794b", - "dad4e", - "dd352", - "b2e91", - "c5061", - "b110f", + "aa6e2", + "b49bd", + "b9a31", + "be8ea", + "c89de", + "cbd42", + "ce8ce", + "e1bde", + "e7327", "a28fc", "fb892", - "c51ee", + "f762c", "a4afa", "a5aa8", "a5e45", @@ -11803,22 +11685,22 @@ "ef3c1", "f1141", "fb829", - "cb44e", - "d6984", - "c07c3", - "c1501", - "f0bb7", - "c7b83", - "b9ff7", - "c2c34", - "f4a3f", - "c623d", - "b7070", + "a0117", + "a4831", + "aa703", + "adf7b", + "b2925", + "b5388", + "bf741", + "c46ee", + "f60e4", + "fef7c", + "ffa8d", "bcf29", "af46d", "b6986", "a01e3", - "cfbca", + "aea74", "e55e9", "c271e", "a721a", @@ -11831,7 +11713,7 @@ "dc4c7", "c4c5e" ], - "dataSourceVersion": "WP3213_r107069", + "dataSourceVersion": "WP3213_r134265", "displayName": "Interferon type I signaling pathways", "drawAs": "rect", "fill": "white", @@ -11839,9 +11721,9 @@ "fontWeight": "bold", "gpmlElementName": "Pathway", "height": 981, - "id": "http://identifiers.org/wikipathways/WP3213", + "id": "WP3213", "kaavioType": "Group", - "lastModified": "20190917141539", + "lastModified": "20240719063556", "name": "Interferon type I signaling pathways", "organism": "Bos taurus", "padding": 5, @@ -11850,7 +11732,7 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Interferon type I signaling pathways\nLast Modified: 20190917141539\nOrganism: Bos taurus", + "textContent": "Name: Interferon type I signaling pathways\nLast Modified: 20240719063556\nOrganism: Bos taurus", "type": [ "Pathway", "http://identifiers.org/pw/PW:0000209", diff --git a/pathways/WP3213/WP3213.png b/pathways/WP3213/WP3213.png index 5557dc942..ec0f541c6 100644 Binary files a/pathways/WP3213/WP3213.png and b/pathways/WP3213/WP3213.png differ diff --git a/pathways/WP3213/WP3213.svg b/pathways/WP3213/WP3213.svg index 2b8b13d8a..8cf342e06 100644 --- a/pathways/WP3213/WP3213.svg +++ b/pathways/WP3213/WP3213.svg @@ -1,5 +1,5 @@ - + @@ -508,8 +508,8 @@ - - + + @@ -525,9 +525,9 @@ - + - + @@ -721,8 +721,8 @@ - - + + @@ -746,8 +746,8 @@ - - + + @@ -870,9 +870,9 @@ - + - + @@ -943,8 +943,8 @@ - - + + @@ -985,8 +985,8 @@ - - + + @@ -1009,8 +1009,8 @@ - - + + @@ -1024,8 +1024,8 @@ - - + + @@ -1039,8 +1039,8 @@ - - + + @@ -1057,8 +1057,8 @@ - - + + @@ -1069,8 +1069,8 @@ - - + + @@ -1081,8 +1081,8 @@ - - + + @@ -1117,8 +1117,8 @@ - - + + @@ -1165,8 +1165,8 @@ Negative regulators of IFN transcription - - + + @@ -1282,7 +1282,7 @@ IRS1 - + SOCS1 @@ -1414,8 +1414,8 @@ GNB2L1 - - + + @@ -1429,8 +1429,8 @@ - - + + @@ -1444,8 +1444,8 @@ - - + + @@ -1459,8 +1459,8 @@ - - + + @@ -1474,8 +1474,8 @@ - - + + @@ -1489,8 +1489,8 @@ - - + + @@ -1504,8 +1504,8 @@ - - + + @@ -1519,8 +1519,8 @@ - - + + @@ -1534,8 +1534,8 @@ - - + + @@ -1549,8 +1549,8 @@ - - + + @@ -1564,8 +1564,8 @@ - - + + @@ -1597,8 +1597,8 @@ NFkB - - + + @@ -1681,9 +1681,9 @@ Trans-Signalling - + Name: Interferon type I signaling pathways - Last Modified: 20190917141539 + Last Modified: 20240719063556 Organism: Bos taurus diff --git a/pathways/WP3223/WP3223-bibliography.tsv b/pathways/WP3223/WP3223-bibliography.tsv index 6e69ebce2..b20b2afec 100644 --- a/pathways/WP3223/WP3223-bibliography.tsv +++ b/pathways/WP3223/WP3223-bibliography.tsv @@ -1,4 +1,4 @@ ID Database Citation -21673720 Pubmed "David S, Kroner A. Repertoire of microglial and macrophage responses after spinal cord injury. Nat Rev Neurosci. 2011 Jun 15;12(7):388–99. PubMed Europe PMC Scholia" -21771809 Pubmed "Poulain M, Ober EA. Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development. Development. 2011 Aug;138(16):3557–68. PubMed Europe PMC Scholia" -23045704 Pubmed "Chou ST, Byrska-Bishop M, Tober JM, Yao Y, Vandorn D, Opalinska JB, et al. Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17573–8. PubMed Europe PMC Scholia" +21673720 Pubmed "Repertoire of microglial and macrophage responses after spinal cord injury. David S, Kroner A. Nat Rev Neurosci. 2011 Jun 15;12(7):388–99. PubMed Europe PMC Scholia" +21771809 Pubmed "Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development. Poulain M, Ober EA. Development. 2011 Aug;138(16):3557–68. PubMed Europe PMC Scholia" +23045704 Pubmed "Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells. Chou ST, Byrska-Bishop M, Tober JM, Yao Y, Vandorn D, Opalinska JB, et al. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17573–8. PubMed Europe PMC Scholia" diff --git a/pathways/WP3223/WP3223-datanodes.tsv b/pathways/WP3223/WP3223-datanodes.tsv index 99b5f9015..5ef5af9db 100644 --- a/pathways/WP3223/WP3223-datanodes.tsv +++ b/pathways/WP3223/WP3223-datanodes.tsv @@ -1,124 +1,59 @@ -Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI -Ascorbic acid Metabolite hmdb:HMDB0000044 chebi:29073;chebi:29073 inchikey:CIWBSHSKHKDKBQ-JLAZNSOCSA-N -A-83-01 Metabolite pubchem.compound:16218924 wikidata:Q26998219 inchikey:HIJMSZGHKQPPJS-UHFFFAOYSA-N -Selenium Metabolite hmdb:HMDB0001349 chebi:60871;chebi:60871 inchikey:MFSBVGSNNPNWMD-UHFFFAOYSA-N -Retinoic acid Metabolite hmdb:HMDB0001852 chebi:15367;chebi:15367 inchikey:SHGAZHPCJJPHSC-YCNIQYBTSA-N -Niacinamide Metabolite hmdb:HMDB0001406 chebi:17154;chebi:17154 inchikey:DFPAKSUCGFBDDF-UHFFFAOYSA-N -SB431542 Metabolite pubchem.compound:4521392 http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4521392
Type your comment here wikidata:Q7388913 chebi:91108;chebi:91108 inchikey:FHYUGAJXYORMHI-UHFFFAOYSA-N -Cyclopamine Metabolite pubchem.compound:442972 wikidata:Q3271319 chebi:4021;chebi:4021 inchikey:QASFUMOKHFSJGL-LAFRSMQTSA-N -DAPT Metabolite pubchem.compound:5311272 http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5311272&loc=ec_rcs
Type your comment here wikidata:Q27158972 chebi:86193;chebi:86193 inchikey:DWJXYEABWRJFSP-XOBRGWDASA-N -Retinoic acid Metabolite hmdb:HMDB0001852 chebi:15367;chebi:15367 inchikey:SHGAZHPCJJPHSC-YCNIQYBTSA-N -SB431542 Metabolite pubchem.compound:4521392 http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4521392
Type your comment here wikidata:Q7388913 chebi:91108;chebi:91108 inchikey:FHYUGAJXYORMHI-UHFFFAOYSA-N -Ascorbic acid Metabolite hmdb:HMDB0000044 chebi:29073;chebi:29073 inchikey:CIWBSHSKHKDKBQ-JLAZNSOCSA-N -Beta-Glycerophosphoric acid Metabolite hmdb:HMDB0002520 chebi:17270;chebi:17270 inchikey:DHCLVCXQIBBOPH-UHFFFAOYSA-N -Dexamethasone Metabolite hmdb:HMDB0015364 chebi:41879;chebi:41879 inchikey:UREBDLICKHMUKA-CXSFZGCWSA-N -Dexamethasone Metabolite hmdb:HMDB0015364 chebi:41879;chebi:41879 inchikey:UREBDLICKHMUKA-CXSFZGCWSA-N -Niacinamide Metabolite hmdb:HMDB0001406 chebi:17154;chebi:17154 inchikey:DFPAKSUCGFBDDF-UHFFFAOYSA-N -Taurine Metabolite hmdb:HMDB0000251 chebi:15891;chebi:15891 inchikey:XOAAWQZATWQOTB-UHFFFAOYSA-N -Vitamin A Metabolite hmdb:HMDB0000305 chebi:17336;chebi:17336 inchikey:FPIPGXGPPPQFEQ-OVSJKPMPSA-N -Naltrexone Metabolite hmdb:HMDB0014842 chebi:7465;chebi:7465 inchikey:DQCKKXVULJGBQN-XFWGSAIBSA-N -Retinoic acid Metabolite hmdb:HMDB0001852 chebi:15367;chebi:15367 inchikey:SHGAZHPCJJPHSC-YCNIQYBTSA-N -Vitamin A Metabolite hmdb:HMDB0000305 chebi:17336;chebi:17336 inchikey:FPIPGXGPPPQFEQ-OVSJKPMPSA-N -NT5E GeneProduct ensembl:ENSBTAG00000045976 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135318 -INHBA GeneProduct ensembl:ENSBTAG00000002912 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3624 -FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685 ensembl:ENSBTAG00000005691 ncbigene:281161 uniprot:P03969 -CXCR2 GeneProduct ensembl:ENSBTAG00000026753 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163464 ensembl:ENSBTAG00000026753 ncbigene:281863 uniprot:G5E6Q0 -SHH GeneProduct ensembl:ENSBTAG00000024552 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164690 ensembl:ENSBTAG00000024552 ncbigene:286821 uniprot:A0A3Q1MQ63;uniprot:F1MM97 -BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378 ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 -TGFB1 GeneProduct ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040 ensembl:ENSBTAG00000020457 ncbigene:282089 uniprot:A0A3Q1NIZ0;uniprot:E1BNK3;uniprot:A0A3Q1N449;uniprot:A0A3Q1MK62 -NOG GeneProduct ensembl:ENSBTAG00000040282 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183691 ensembl:ENSBTAG00000040282 ncbigene:538769 uniprot:G3N3L0 -BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378 ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 -KIT GeneProduct ensembl:ENSBTAG00000002699 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157404 ensembl:ENSBTAG00000002699 ncbigene:280832 uniprot:A0A452DHX3 -VEGFA GeneProduct ensembl:ENSBTAG00000047561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112715 -FGF4 GeneProduct ensembl:ENSBTAG00000012563 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000075388 ensembl:ENSBTAG00000012563 ncbigene:618474 uniprot:G3XGD3 -IGF-I GeneProduct ensembl:ENSBTAG00000011082 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000017427 ensembl:ENSBTAG00000011082 ncbigene:281239 uniprot:F2X2F0;uniprot:P07455;uniprot:F2X2F3;uniprot:F2X2F1 -HGF GeneProduct ensembl:ENSBTAG00000017664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019991 ensembl:ENSBTAG00000017664 ncbigene:282879 uniprot:F1MZD6;uniprot:A0A3Q1LSS6 -NOTCH1 GeneProduct ensembl:ENSBTAG00000022799 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4851 ensembl:ENSBTAG00000022799 ncbigene:767866 uniprot:A0A3Q1N607;uniprot:F1MSM3 -BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378 ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 -NOG GeneProduct ensembl:ENSBTAG00000040282 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183691 ensembl:ENSBTAG00000040282 ncbigene:538769 uniprot:G3N3L0 -WNT3A GeneProduct ensembl:ENSBTAG00000039397 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154342 ensembl:ENSBTAG00000039397 ncbigene:522467 uniprot:F1MDZ7;uniprot:A0A3Q1LTW2 -HGF GeneProduct ensembl:ENSBTAG00000017664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019991 ensembl:ENSBTAG00000017664 ncbigene:282879 uniprot:F1MZD6;uniprot:A0A3Q1LSS6 -FGF4 GeneProduct ensembl:ENSBTAG00000012563 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000075388 ensembl:ENSBTAG00000012563 ncbigene:618474 uniprot:G3XGD3 -NODAL GeneProduct ensembl:ENSBTAG00000013090 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000156574 ensembl:ENSBTAG00000013090 ncbigene:530748 uniprot:E1BJ34 -BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378 ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 -VEGFA GeneProduct ensembl:ENSBTAG00000047561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112715 -KITLG GeneProduct ensembl:ENSBTAG00000017549 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130 ensembl:ENSBTAG00000017549 ncbigene:281885 uniprot:A0A452DIS8;uniprot:Q28132;uniprot:A0A3Q1M8Q1 -FLT3LG GeneProduct ensembl:ENSBTAG00000038045 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090554 ensembl:ENSBTAG00000038045 ncbigene:282233 uniprot:A2VE24 -KITLG GeneProduct ensembl:ENSBTAG00000017549 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130 ensembl:ENSBTAG00000017549 ncbigene:281885 uniprot:A0A452DIS8;uniprot:Q28132;uniprot:A0A3Q1M8Q1 -CSF1 GeneProduct ensembl:ENSBTAG00000000283 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184371 ensembl:ENSBTAG00000000283 ncbigene:281094 uniprot:F1MGS9;uniprot:A0A3Q1LMK4 -IL6 GeneProduct ensembl:ENSBTAG00000014921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244 ensembl:ENSBTAG00000014921 ncbigene:280826 uniprot:P26892 -VEGFA GeneProduct ensembl:ENSBTAG00000047561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112715 -BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378 ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 -KITLG GeneProduct ensembl:ENSBTAG00000017549 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130 ensembl:ENSBTAG00000017549 ncbigene:281885 uniprot:A0A452DIS8;uniprot:Q28132;uniprot:A0A3Q1M8Q1 -EPO GeneProduct ensembl:ENSBTAG00000003430 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130427 ensembl:ENSBTAG00000003430 ncbigene:280784 uniprot:P48617;uniprot:A0A452DI21 -INHBA GeneProduct ensembl:ENSBTAG00000002912 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122641 -FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685 ensembl:ENSBTAG00000005691 ncbigene:281161 uniprot:P03969 -BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378 ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 -FLT3LG GeneProduct ensembl:ENSBTAG00000038045 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090554 ensembl:ENSBTAG00000038045 ncbigene:282233 uniprot:A2VE24 -FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685 ensembl:ENSBTAG00000005691 ncbigene:281161 uniprot:P03969 -VEGFA GeneProduct ensembl:ENSBTAG00000047561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112715 -FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685 ensembl:ENSBTAG00000005691 ncbigene:281161 uniprot:P03969 -TGFB1 GeneProduct ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040 ensembl:ENSBTAG00000020457 ncbigene:282089 uniprot:A0A3Q1NIZ0;uniprot:E1BNK3;uniprot:A0A3Q1N449;uniprot:A0A3Q1MK62 -PDGFB GeneProduct ensembl:ENSBTAG00000021697 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100311 ensembl:ENSBTAG00000021697 ncbigene:540106 uniprot:B1H0W5;uniprot:Q58D48;uniprot:A0A3Q1N062 -IL6 GeneProduct ensembl:ENSBTAG00000014921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244 ensembl:ENSBTAG00000014921 ncbigene:280826 uniprot:P26892 -VEGFA GeneProduct ensembl:ENSBTAG00000047561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112715 -KITLG GeneProduct ensembl:ENSBTAG00000017549 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130 ensembl:ENSBTAG00000017549 ncbigene:281885 uniprot:A0A452DIS8;uniprot:Q28132;uniprot:A0A3Q1M8Q1 -IL11 GeneProduct ensembl:ENSBTAG00000047400 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000095752 -DKK1 GeneProduct ensembl:ENSBTAG00000014218 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107984 ensembl:ENSBTAG00000014218 ncbigene:504445 uniprot:A0A3Q1LM37;uniprot:E1BM54 -VEGFA GeneProduct ensembl:ENSBTAG00000047561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112715 -WNT1 GeneProduct ensembl:ENSBTAG00000015364 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125084 ensembl:ENSBTAG00000015364 ncbigene:540662 uniprot:E1BEN9 -DKK1 GeneProduct ensembl:ENSBTAG00000014218 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107984 ensembl:ENSBTAG00000014218 ncbigene:504445 uniprot:A0A3Q1LM37;uniprot:E1BM54 -WNT1 GeneProduct ensembl:ENSBTAG00000015364 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125084 ensembl:ENSBTAG00000015364 ncbigene:540662 uniprot:E1BEN9 -VEGFA GeneProduct ensembl:ENSBTAG00000047561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112715 -TGFB3 GeneProduct ensembl:ENSBTAG00000012004 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119699 ensembl:ENSBTAG00000012004 ncbigene:538957 uniprot:A6QP91 -NTF4 GeneProduct ensembl:ENSBTAG00000047078 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000225950 ensembl:ENSBTAG00000047078 ncbigene:506660 uniprot:G3MYR8 -FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685 ensembl:ENSBTAG00000005691 ncbigene:281161 uniprot:P03969 -BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378 ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 -FST GeneProduct ensembl:ENSBTAG00000003329 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134363 ensembl:ENSBTAG00000003329 ncbigene:327681 uniprot:P50291 -NTF4 GeneProduct ensembl:ENSBTAG00000047078 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000225950 ensembl:ENSBTAG00000047078 ncbigene:506660 uniprot:G3MYR8 -BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378 ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 -FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685 ensembl:ENSBTAG00000005691 ncbigene:281161 uniprot:P03969 -GDF5 GeneProduct ensembl:ENSBTAG00000004429 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125965 ensembl:ENSBTAG00000004429 ncbigene:539559 uniprot:F1MT44 -TF GeneProduct ensembl:ENSBTAG00000007273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091513 ensembl:ENSBTAG00000007273 ncbigene:280705 uniprot:G3X6N3 -VEGFA GeneProduct ensembl:ENSBTAG00000047561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112715 -EPO GeneProduct ensembl:ENSBTAG00000003430 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130427 ensembl:ENSBTAG00000003430 ncbigene:280784 uniprot:P48617;uniprot:A0A452DI21 -IL6 GeneProduct ensembl:ENSBTAG00000014921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244 ensembl:ENSBTAG00000014921 ncbigene:280826 uniprot:P26892 -IL11 GeneProduct ensembl:ENSBTAG00000047400 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000095752 -CSF1R GeneProduct ensembl:ENSBTAG00000012771 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182578 ensembl:ENSBTAG00000012771 ncbigene:509418 uniprot:A7Z067 -TNFSF11 GeneProduct ensembl:ENSBTAG00000008924 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120659 ensembl:ENSBTAG00000008924 ncbigene:513836 uniprot:E1BIP0 -BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378 ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 -WNT2B GeneProduct ensembl:ENSBTAG00000014291 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7482 ensembl:ENSBTAG00000014291 ncbigene:445420 uniprot:A6H6X8 -WNT5A GeneProduct ensembl:ENSBTAG00000020221 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7474 ensembl:ENSBTAG00000020221 ncbigene:530005 uniprot:E1BDG5 -WNT7B GeneProduct ensembl:ENSBTAG00000009532 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7477 -WNT2 GeneProduct ensembl:ENSBTAG00000008097 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7472 ensembl:ENSBTAG00000008097 ncbigene:493729 uniprot:A4D7S0 -FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685 ensembl:ENSBTAG00000005691 ncbigene:281161 uniprot:P03969 -IL6 GeneProduct ensembl:ENSBTAG00000014921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244 ensembl:ENSBTAG00000014921 ncbigene:280826 uniprot:P26892 -IL6R GeneProduct ensembl:ENSBTAG00000018474 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160712 ensembl:ENSBTAG00000018474 ncbigene:507359 uniprot:E1BJQ3 -BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378 ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 -FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685 ensembl:ENSBTAG00000005691 ncbigene:281161 uniprot:P03969 -INHBA GeneProduct ensembl:ENSBTAG00000002912 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122641 -SHH GeneProduct ensembl:ENSBTAG00000024552 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164690 ensembl:ENSBTAG00000024552 ncbigene:286821 uniprot:A0A3Q1MQ63;uniprot:F1MM97 -IGF-I GeneProduct ensembl:ENSBTAG00000011082 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000017427 ensembl:ENSBTAG00000011082 ncbigene:281239 uniprot:F2X2F0;uniprot:P07455;uniprot:F2X2F3;uniprot:F2X2F1 -FGF8 GeneProduct ensembl:ENSBTAG00000001530 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107831 ensembl:ENSBTAG00000001530 ncbigene:326284 uniprot:F1N6G8 -WNT1 GeneProduct ensembl:ENSBTAG00000015364 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125084 ensembl:ENSBTAG00000015364 ncbigene:540662 uniprot:E1BEN9 -ALK GeneProduct ensembl:ENSBTAG00000007379 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171094 ensembl:ENSBTAG00000007379 ncbigene:536642 uniprot:A0A3Q1LTX0;uniprot:A0A3Q1MKW9;uniprot:A0A3Q1NGY3;uniprot:A0A3Q1LXZ1;uniprot:A0A3Q1M2C1;uniprot:F1MUQ3;uniprot:A0A3Q1M1I2;uniprot:A0A3Q1M7V9;uniprot:F1MQH1;uniprot:A0A3Q1M943 -LEFTY1 GeneProduct ensembl:ENSBTAG00000002855 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000243709 -SHH GeneProduct ensembl:ENSBTAG00000024552 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164690 ensembl:ENSBTAG00000024552 ncbigene:286821 uniprot:A0A3Q1MQ63;uniprot:F1MM97 -BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378 ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 -CNTF GeneProduct ensembl:ENSBTAG00000003624 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000242689 ensembl:ENSBTAG00000003624 ncbigene:100848228 uniprot:E1BFH9 -FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685 ensembl:ENSBTAG00000005691 ncbigene:281161 uniprot:P03969 -NODAL GeneProduct ensembl:ENSBTAG00000013090 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000156574 ensembl:ENSBTAG00000013090 ncbigene:530748 uniprot:E1BJ34 -DKK1 GeneProduct ensembl:ENSBTAG00000014218 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107984 ensembl:ENSBTAG00000014218 ncbigene:504445 uniprot:A0A3Q1LM37;uniprot:E1BM54 -PDGFA GeneProduct ensembl:ENSBTAG00000014541 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197461 ensembl:ENSBTAG00000014541 ncbigene:505908 uniprot:A0A3Q1M114;uniprot:A0A3Q1NM64;uniprot:Q2KJ15 -FGF1 GeneProduct ensembl:ENSBTAG00000005198 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113578 ensembl:ENSBTAG00000005198 ncbigene:281160 uniprot:P03968;uniprot:A0A7U3JWD0 -FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685 ensembl:ENSBTAG00000005691 ncbigene:281161 uniprot:P03969 -NOG GeneProduct ensembl:ENSBTAG00000040282 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183691 ensembl:ENSBTAG00000040282 ncbigene:538769 uniprot:G3N3L0 -SHH GeneProduct ensembl:ENSBTAG00000024552 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164690 ensembl:ENSBTAG00000024552 ncbigene:286821 uniprot:A0A3Q1MQ63;uniprot:F1MM97 -SHH GeneProduct ensembl:ENSBTAG00000024552 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164690 ensembl:ENSBTAG00000024552 ncbigene:286821 uniprot:A0A3Q1MQ63;uniprot:F1MM97 -INHBA GeneProduct ensembl:ENSBTAG00000002912 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3624 -INHBA GeneProduct ensembl:ENSBTAG00000002912 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3624 -BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:652 ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 -IGF-I GeneProduct ensembl:ENSBTAG00000011082 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000017427 ensembl:ENSBTAG00000011082 ncbigene:281239 uniprot:F2X2F0;uniprot:P07455;uniprot:F2X2F3;uniprot:F2X2F1 -EPO GeneProduct ensembl:ENSBTAG00000003430 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130427 ensembl:ENSBTAG00000003430 ncbigene:280784 uniprot:P48617;uniprot:A0A452DI21 -FLT3LG GeneProduct ensembl:ENSBTAG00000038045 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090554 ensembl:ENSBTAG00000038045 ncbigene:282233 uniprot:A2VE24 -FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685 ensembl:ENSBTAG00000005691 ncbigene:281161 uniprot:P03969 +Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps +Ascorbic acid Metabolite hmdb:HMDB0000044 "" chebi:29073 inchikey:CIWBSHSKHKDKBQ-JLAZNSOCSA-N chemspider:10189562 hmdb:HMDB0000044 kegg.compound:C01041 +A-83-01 Metabolite pubchem.compound:16218924 "" wikidata:Q26998219 inchikey:HIJMSZGHKQPPJS-UHFFFAOYSA-N pubchem.compound:16218924 chemspider:17346282 hmdb:HMDB0247640 +Selenium Metabolite hmdb:HMDB0001349 "" chebi:60871 inchikey:MFSBVGSNNPNWMD-UHFFFAOYSA-N chemspider:27471292 hmdb:HMDB0001349 kegg.compound:C01529 +Retinoic acid Metabolite hmdb:HMDB0001852 "" chebi:15367 inchikey:SHGAZHPCJJPHSC-YCNIQYBTSA-N pubchem.compound:444795 chemspider:392618 hmdb:HMDB0001852 kegg.compound:C00777 +Niacinamide Metabolite hmdb:HMDB0001406 "" chebi:17154 inchikey:DFPAKSUCGFBDDF-UHFFFAOYSA-N pubchem.compound:936 chemspider:911 hmdb:HMDB0001406 kegg.compound:C00153 +SB431542 Metabolite pubchem.compound:4521392 "http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4521392" wikidata:Q7388913 chebi:91108 inchikey:FHYUGAJXYORMHI-UHFFFAOYSA-N pubchem.compound:4521392 chemspider:3716512 hmdb:HMDB0246120 +Cyclopamine Metabolite pubchem.compound:442972 "" wikidata:Q3271319 chebi:4021 inchikey:QASFUMOKHFSJGL-LAFRSMQTSA-N pubchem.compound:442972 chemspider:391275 kegg.compound:C10798 +DAPT Metabolite pubchem.compound:5311272 "http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5311272&loc=ec_rcs" wikidata:Q27158972 chebi:86193 inchikey:DWJXYEABWRJFSP-XOBRGWDASA-N pubchem.compound:5311272 chemspider:4470783 +Beta-Glycerophosphoric acid Metabolite hmdb:HMDB0002520 "" chebi:17270 inchikey:DHCLVCXQIBBOPH-UHFFFAOYSA-N pubchem.compound:2526 chemspider:2431 hmdb:HMDB0002520 kegg.compound:C02979 +Dexamethasone Metabolite hmdb:HMDB0015364 "" chebi:41879 inchikey:UREBDLICKHMUKA-CXSFZGCWSA-N pubchem.compound:5743 chemspider:5541 hmdb:HMDB0015364 kegg.compound:C15643 +Taurine Metabolite hmdb:HMDB0000251 "" chebi:15891 inchikey:XOAAWQZATWQOTB-UHFFFAOYSA-N pubchem.compound:1123 chemspider:1091 hmdb:HMDB0000251 kegg.compound:C00245 +Vitamin A Metabolite hmdb:HMDB0000305 "" chebi:17336 inchikey:FPIPGXGPPPQFEQ-OVSJKPMPSA-N pubchem.compound:445354 hmdb:HMDB0000305 kegg.compound:C17276 +Naltrexone Metabolite hmdb:HMDB0014842 "" chebi:7465 inchikey:DQCKKXVULJGBQN-XFWGSAIBSA-N pubchem.compound:5360515 chemspider:4514524 hmdb:HMDB0014842 kegg.compound:C07253 +NT5E GeneProduct ensembl:ENSBTAG00000045976 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135318" +INHBA GeneProduct ensembl:ENSBTAG00000002912 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3624" +FGF2 GeneProduct ensembl:ENSBTAG00000005691 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685" ensembl:ENSBTAG00000005691 ncbigene:281161 uniprot:P03969 +CXCR2 GeneProduct ensembl:ENSBTAG00000026753 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163464" ensembl:ENSBTAG00000026753 ncbigene:281863 uniprot:G5E6Q0 +SHH GeneProduct ensembl:ENSBTAG00000024552 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164690" ensembl:ENSBTAG00000024552 ncbigene:286821 uniprot:A0A3Q1MQ63;uniprot:F1MM97 +BMP4 GeneProduct ensembl:ENSBTAG00000003835 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378" ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 +TGFB1 GeneProduct ensembl:ENSBTAG00000020457 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040" ensembl:ENSBTAG00000020457 ncbigene:282089 uniprot:A0A3Q1NIZ0;uniprot:E1BNK3;uniprot:A0A3Q1N449;uniprot:A0A3Q1MK62 +NOG GeneProduct ensembl:ENSBTAG00000040282 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183691" ensembl:ENSBTAG00000040282 ncbigene:538769 uniprot:G3N3L0 +KIT GeneProduct ensembl:ENSBTAG00000002699 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157404" ensembl:ENSBTAG00000002699 ncbigene:280832 uniprot:A0A452DHX3 +VEGFA GeneProduct ensembl:ENSBTAG00000047561 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112715" +FGF4 GeneProduct ensembl:ENSBTAG00000012563 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000075388" ensembl:ENSBTAG00000012563 ncbigene:618474 uniprot:G3XGD3 +IGF-I GeneProduct ensembl:ENSBTAG00000011082 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000017427" ensembl:ENSBTAG00000011082 ncbigene:281239 uniprot:F2X2F0;uniprot:P07455;uniprot:F2X2F3;uniprot:F2X2F1 +HGF GeneProduct ensembl:ENSBTAG00000017664 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019991" ensembl:ENSBTAG00000017664 ncbigene:282879 uniprot:F1MZD6;uniprot:A0A3Q1LSS6 +NOTCH1 GeneProduct ensembl:ENSBTAG00000022799 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4851" ensembl:ENSBTAG00000022799 ncbigene:767866 uniprot:A0A3Q1N607;uniprot:F1MSM3 +WNT3A GeneProduct ensembl:ENSBTAG00000039397 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154342" ensembl:ENSBTAG00000039397 ncbigene:522467 uniprot:F1MDZ7;uniprot:A0A3Q1LTW2 +NODAL GeneProduct ensembl:ENSBTAG00000013090 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000156574" ensembl:ENSBTAG00000013090 ncbigene:530748 uniprot:E1BJ34 +KITLG GeneProduct ensembl:ENSBTAG00000017549 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130" ensembl:ENSBTAG00000017549 ncbigene:281885 uniprot:A0A452DIS8;uniprot:Q28132;uniprot:A0A3Q1M8Q1 +FLT3LG GeneProduct ensembl:ENSBTAG00000038045 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090554" ensembl:ENSBTAG00000038045 ncbigene:282233 uniprot:A2VE24 +CSF1 GeneProduct ensembl:ENSBTAG00000000283 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184371" ensembl:ENSBTAG00000000283 ncbigene:281094 uniprot:F1MGS9;uniprot:A0A3Q1LMK4 +IL6 GeneProduct ensembl:ENSBTAG00000014921 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244" ensembl:ENSBTAG00000014921 ncbigene:280826 uniprot:P26892 +EPO GeneProduct ensembl:ENSBTAG00000003430 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130427" ensembl:ENSBTAG00000003430 ncbigene:280784 uniprot:P48617;uniprot:A0A452DI21 +INHBA GeneProduct ensembl:ENSBTAG00000002912 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122641" +PDGFB GeneProduct ensembl:ENSBTAG00000021697 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100311" ensembl:ENSBTAG00000021697 ncbigene:540106 uniprot:B1H0W5;uniprot:Q58D48;uniprot:A0A3Q1N062 +IL11 GeneProduct ensembl:ENSBTAG00000047400 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000095752" +DKK1 GeneProduct ensembl:ENSBTAG00000014218 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107984" ensembl:ENSBTAG00000014218 ncbigene:504445 uniprot:A0A3Q1LM37;uniprot:E1BM54 +WNT1 GeneProduct ensembl:ENSBTAG00000015364 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125084" ensembl:ENSBTAG00000015364 ncbigene:540662 uniprot:E1BEN9 +TGFB3 GeneProduct ensembl:ENSBTAG00000012004 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119699" ensembl:ENSBTAG00000012004 ncbigene:538957 uniprot:A6QP91 +NTF4 GeneProduct ensembl:ENSBTAG00000047078 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000225950" ensembl:ENSBTAG00000047078 ncbigene:506660 uniprot:G3MYR8 +FST GeneProduct ensembl:ENSBTAG00000003329 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134363" ensembl:ENSBTAG00000003329 ncbigene:327681 uniprot:P50291 +GDF5 GeneProduct ensembl:ENSBTAG00000004429 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125965" ensembl:ENSBTAG00000004429 ncbigene:539559 uniprot:F1MT44 +TF GeneProduct ensembl:ENSBTAG00000007273 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091513" ensembl:ENSBTAG00000007273 ncbigene:280705 uniprot:G3X6N3 +CSF1R GeneProduct ensembl:ENSBTAG00000012771 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182578" ensembl:ENSBTAG00000012771 ncbigene:509418 uniprot:A7Z067 +TNFSF11 GeneProduct ensembl:ENSBTAG00000008924 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120659" ensembl:ENSBTAG00000008924 ncbigene:513836 uniprot:E1BIP0 +WNT2B GeneProduct ensembl:ENSBTAG00000014291 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7482" ensembl:ENSBTAG00000014291 ncbigene:445420 uniprot:A6H6X8 +WNT5A GeneProduct ensembl:ENSBTAG00000020221 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7474" ensembl:ENSBTAG00000020221 ncbigene:530005 uniprot:E1BDG5 +WNT7B GeneProduct ensembl:ENSBTAG00000009532 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7477" +WNT2 GeneProduct ensembl:ENSBTAG00000008097 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7472" ensembl:ENSBTAG00000008097 ncbigene:493729 uniprot:A4D7S0 +IL6R GeneProduct ensembl:ENSBTAG00000018474 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160712" ensembl:ENSBTAG00000018474 ncbigene:507359 uniprot:E1BJQ3 +FGF8 GeneProduct ensembl:ENSBTAG00000001530 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107831" ensembl:ENSBTAG00000001530 ncbigene:326284 uniprot:F1N6G8 +ALK GeneProduct ensembl:ENSBTAG00000007379 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171094" ensembl:ENSBTAG00000007379 ncbigene:536642 uniprot:A0A3Q1LTX0;uniprot:A0A3Q1MKW9;uniprot:A0A3Q1NGY3;uniprot:A0A3Q1LXZ1;uniprot:A0A3Q1M2C1;uniprot:F1MUQ3;uniprot:A0A3Q1M1I2;uniprot:A0A3Q1M7V9;uniprot:F1MQH1;uniprot:A0A3Q1M943 +LEFTY1 GeneProduct ensembl:ENSBTAG00000002855 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000243709" +CNTF GeneProduct ensembl:ENSBTAG00000003624 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000242689" ensembl:ENSBTAG00000003624 ncbigene:100848228 uniprot:E1BFH9 +PDGFA GeneProduct ensembl:ENSBTAG00000014541 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197461" ensembl:ENSBTAG00000014541 ncbigene:505908 uniprot:A0A3Q1M114;uniprot:A0A3Q1NM64;uniprot:Q2KJ15 +FGF1 GeneProduct ensembl:ENSBTAG00000005198 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113578" ensembl:ENSBTAG00000005198 ncbigene:281160 uniprot:P03968;uniprot:A0A7U3JWD0 +BMP4 GeneProduct ensembl:ENSBTAG00000003835 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:652" ensembl:ENSBTAG00000003835 ncbigene:407216 uniprot:Q2KJH1 diff --git a/pathways/WP3223/WP3223.gpml b/pathways/WP3223/WP3223.gpml index cbe1e5db5..bbe3aca90 100644 --- a/pathways/WP3223/WP3223.gpml +++ b/pathways/WP3223/WP3223.gpml @@ -1,5 +1,5 @@ - + This pathway provides an overview of the directed differentiation molecules used to induce early and derivative cell lineages from human pluripotent stem cells. The initial version of this pathway is a direct adaptation of the SnapShot "Directed Differentiation of Pluripotent Stem Cells" pathway authored by Luis A. Williams, Brandi N. Davis-Dusenbery, and Kevin C. Eggan, HHMI, Harvard University, Cell 149, May 25, 2012 Elsevier Inc. DOI 10.1016/j.cell.2012.05.015. http://download.cell.com/pdf/PIIS0092867412005946.pdf. This adaptation was generated by Meenakshi Venkatasubramanian and Krithika Ramasamy Subramanian at Cincinnati Children's Hospital in the laboratory of Nathan Salomonis. This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP2848_r80009 WP2848(80009)] with a 85.0% conversion rate. dce @@ -71,7 +71,6 @@ http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4521392 - Type your comment here @@ -81,7 +80,6 @@ http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5311272&loc=ec_rcs - Type your comment here @@ -281,7 +279,6 @@ http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4521392 - Type your comment here @@ -677,689 +674,689 @@ - - + + - - + + - - + + - - + + - - - + + + - - + + - - - + + + - - - - - + + + + + - - + + - - + + - - + + - - + + - - + + - - - - - + + + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - - + + + - - + + - - + + - - + + - - + + - - - - + + + + - - + + - - - + + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - - - - - - + + + + + + + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + + diff --git a/pathways/WP3223/WP3223.json b/pathways/WP3223/WP3223.json index 44625ca1e..4b6b07b08 100644 --- a/pathways/WP3223/WP3223.json +++ b/pathways/WP3223/WP3223.json @@ -1,93 +1,5 @@ { "entitiesById": { - "183889": { - "__HighlandStream__": true, - "_can_drain": false, - "_consume_waiting_for_next": false, - "_consumers": [], - "_delegate": null, - "_destructors": [], - "_events": {}, - "_eventsCount": 2, - "_in_consume_cb": false, - "_incoming": [], - "_is_observer": false, - "_nil_pushed": false, - "_observers": [], - "_outgoing": [], - "_repeat_resume": false, - "_send_events": false, - "id": "183889", - "paused": true, - "source": null, - "writable": true - }, - "584610": { - "__HighlandStream__": true, - "_can_drain": false, - "_consume_waiting_for_next": false, - "_consumers": [], - "_delegate": null, - "_destructors": [], - "_events": {}, - "_eventsCount": 2, - "_in_consume_cb": false, - "_incoming": [], - "_is_observer": false, - "_nil_pushed": false, - "_observers": [], - "_outgoing": [], - "_repeat_resume": false, - "_send_events": false, - "id": "584610", - "paused": true, - "source": null, - "writable": true - }, - "641066": { - "__HighlandStream__": true, - "_can_drain": false, - "_consume_waiting_for_next": false, - "_consumers": [], - "_delegate": null, - "_destructors": [], - "_events": {}, - "_eventsCount": 2, - "_in_consume_cb": false, - "_incoming": [], - "_is_observer": false, - "_nil_pushed": false, - "_observers": [], - "_outgoing": [], - "_repeat_resume": false, - "_send_events": false, - "id": "641066", - "paused": true, - "source": null, - "writable": true - }, - "851467": { - "__HighlandStream__": true, - "_can_drain": false, - "_consume_waiting_for_next": false, - "_consumers": [], - "_delegate": null, - "_destructors": [], - "_events": {}, - "_eventsCount": 2, - "_in_consume_cb": false, - "_incoming": [], - "_is_observer": false, - "_nil_pushed": false, - "_observers": [], - "_outgoing": [], - "_repeat_resume": false, - "_send_events": false, - "id": "851467", - "paused": true, - "source": null, - "writable": true - }, "a03a7": { "drawAs": "none", "fill": "transparent", @@ -710,7 +622,7 @@ "gpmlElementName": "Shape", "height": 39, "id": "a2417", - "isPartOf": "e8139", + "isPartOf": "f42ce", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1445,7 +1357,6 @@ 0 ] }, - "id": "ae05e", "isAttachedTo": "b140f", "orientation": [ 0, @@ -1465,7 +1376,6 @@ 1 ] }, - "id": "d1468", "isAttachedTo": "f6592", "orientation": [ 0, @@ -1959,12 +1869,10 @@ "markerEnd": "MimConversion", "points": [ { - "id": "b297f", "x": 816, "y": 578 }, { - "id": "d393b", "x": 1002.2492997198877, "y": 378.66666666666674 } @@ -2127,7 +2035,6 @@ 0.25 ] }, - "id": "b78cf", "isAttachedTo": "d0693", "orientation": [ -1, @@ -2155,7 +2062,6 @@ 0 ] }, - "id": "cbe01", "isAttachedTo": "d0693", "orientation": [ 0, @@ -2298,8 +2204,10 @@ "CompactIdentifier:hmdb:HMDB0000305", "Vitamin A", "ChEBI:17336", - "ChEBI:17336", - "InChI:FPIPGXGPPPQFEQ-OVSJKPMPSA-N" + "InChI:FPIPGXGPPPQFEQ-OVSJKPMPSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2350,12 +2258,10 @@ "kaavioType": "Edge", "points": [ { - "id": "a1a2f", "x": 1512.8151260504242, "y": 159.7422969187675 }, { - "id": "b37fa", "x": 1512.8151260504242, "y": 177.07563025210098 } @@ -2396,8 +2302,11 @@ "CompactIdentifier:hmdb:HMDB0002520", "Beta-Glycerophosphoric acid", "ChEBI:17270", - "ChEBI:17270", - "InChI:DHCLVCXQIBBOPH-UHFFFAOYSA-N" + "InChI:DHCLVCXQIBBOPH-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2437,8 +2346,10 @@ "CompactIdentifier:hmdb:HMDB0000044", "Ascorbic acid", "ChEBI:29073", - "ChEBI:29073", - "InChI:CIWBSHSKHKDKBQ-JLAZNSOCSA-N" + "InChI:CIWBSHSKHKDKBQ-JLAZNSOCSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3157,8 +3068,11 @@ "CompactIdentifier:hmdb:HMDB0014842", "Naltrexone", "ChEBI:7465", - "ChEBI:7465", - "InChI:DQCKKXVULJGBQN-XFWGSAIBSA-N" + "InChI:DQCKKXVULJGBQN-XFWGSAIBSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3421,7 +3335,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "aba86", - "isPartOf": "b63be", + "isPartOf": "bf97f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3905,8 +3819,11 @@ "CompactIdentifier:hmdb:HMDB0000251", "Taurine", "ChEBI:15891", - "ChEBI:15891", - "InChI:XOAAWQZATWQOTB-UHFFFAOYSA-N" + "InChI:XOAAWQZATWQOTB-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4343,7 +4260,7 @@ "gpmlElementName": "Interaction", "id": "ae26d", "isAttachedTo": [ - "c7080" + "ff8c8" ], "kaavioType": "Edge", "markerEnd": "MimInhibition", @@ -4359,8 +4276,7 @@ 0.5 ] }, - "id": "b69a4", - "isAttachedTo": "c7080", + "isAttachedTo": "ff8c8", "orientation": [ 1, 0 @@ -4369,7 +4285,6 @@ "y": 533.2083333333335 }, { - "id": "c9f83", "x": 762, "y": 533.2083333333335 } @@ -5790,7 +5705,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b4857", - "isPartOf": "c7080", + "isPartOf": "ff8c8", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6330,36 +6245,6 @@ "y": 1267.0177871148462, "zIndex": 36853 }, - "b63be": { - "contains": [ - "e8e0d", - "f6996", - "aba86" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 75.9159663865544, - "id": "b63be", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": 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"ChEBI:60871", - "ChEBI:60871", - "InChI:MFSBVGSNNPNWMD-UHFFFAOYSA-N" + "InChI:MFSBVGSNNPNWMD-UHFFFAOYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7679,12 +7571,10 @@ "markerEnd": "MimConversion", "points": [ { - "id": "df279", "x": 1053.2184873949577, "y": 379.79831932773095 }, { - "id": "f7824", "x": 1126.0476190476188, "y": 421.8151260504201 } @@ -7738,7 +7628,7 @@ "gpmlElementName": "Shape", "height": 20.75, "id": "bb901", - "isPartOf": "e8139", + "isPartOf": "f42ce", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8559,8 +8449,11 @@ "CompactIdentifier:hmdb:HMDB0015364", "Dexamethasone", "ChEBI:41879", - "ChEBI:41879", - "InChI:UREBDLICKHMUKA-CXSFZGCWSA-N" + "InChI:UREBDLICKHMUKA-CXSFZGCWSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8855,12 +8748,10 @@ "kaavioType": "Edge", "points": [ { - "id": "fa5b4", "x": 849.2969187675066, "y": 154.0616246498602 }, { - "id": "aab5c", "x": 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1187.0413165266104, + "y": 198.3830532212887, + "zIndex": 37063 + }, "bfa4c": { "drawAs": "none", "fill": "transparent", @@ -9613,7 +9530,6 @@ 1 ] }, - "id": "a96c4", "isAttachedTo": "dacf6", "orientation": [ 0, @@ -9633,7 +9549,6 @@ 0 ] }, - "id": "d37af", "isAttachedTo": "b7c34", "orientation": [ 0, @@ -10101,12 +10016,10 @@ "markerEnd": "MimConversion", "points": [ { - "id": "e3d34", "x": 1039.3137254901953, "y": 335.62500000000045 }, { - "id": "ee114", "x": 1161.0616246498585, "y": 210.33053221288512 } @@ -10220,7 +10133,6 @@ 1 ] }, - "id": "bfb35", "isAttachedTo": "c0e43", "orientation": [ 0, @@ -10240,7 +10152,6 @@ 0 ] }, - "id": "ae5e9", "isAttachedTo": "f1a00", "orientation": [ 0, @@ -10298,12 +10209,10 @@ "markerEnd": "MimConversion", "points": [ { - "id": "d6816", "x": 1028.0084033613443, "y": 347.58543417366946 }, { - "id": "fae0b", "x": 1458.249299719887, "y": 210.6666666666667 } @@ -10373,7 +10282,6 @@ 0.5 ] }, - "id": "a300c", "isAttachedTo": "d821a", "orientation": [ 1, @@ -10383,7 +10291,6 @@ "y": 586.8179271708686 }, { - "id": "ef4bb", "x": 771, "y": 586.8179271708686 } @@ -10518,12 +10425,10 @@ "markerEnd": "MimConversion", "points": [ { - "id": "fe51c", "x": 959.515406162465, "y": 548.5266106442577 }, { - "id": "d06bc", "x": 1071.5602240896355, "y": 507.9103641456584 } @@ -10930,7 +10835,7 @@ "gpmlElementName": "Shape", "height": 39, "id": "c45f7", - "isPartOf": "e8139", + "isPartOf": "f42ce", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -10980,8 +10885,11 @@ "CompactIdentifier:hmdb:HMDB0001852", "Retinoic acid", "ChEBI:15367", - "ChEBI:15367", - "InChI:SHGAZHPCJJPHSC-YCNIQYBTSA-N" + "InChI:SHGAZHPCJJPHSC-YCNIQYBTSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -11118,35 +11026,6 @@ "y": 540.060176670426, "zIndex": 37348 }, - "c55ed": { - "contains": [ - "f2c89", - "fd6cc" - ], - "drawAs": "Octagon", - "fill": "#b4b464", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", 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"CompactIdentifier:hmdb:HMDB0001406", "Niacinamide", "ChEBI:17154", - "ChEBI:17154", - "InChI:DFPAKSUCGFBDDF-UHFFFAOYSA-N" + "InChI:DFPAKSUCGFBDDF-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -14790,7 +14639,7 @@ "gpmlElementName": "Shape", "height": 20.75, "id": "d33c9", - "isPartOf": "e8139", + "isPartOf": "f42ce", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -15541,12 +15390,10 @@ "markerEnd": "MimConversion", "points": [ { - "id": "c4371", "x": 806.6666666666666, "y": 355.3333333333333 }, { - "id": "fc64e", "x": 990.1932773109244, "y": 354.58823529411757 } @@ -15631,12 +15478,10 @@ "markerEnd": "MimConversion", "points": [ { - "id": "d8253", "x": 404.17647058823565, "y": 311.59663865546213 }, { - "id": "d29e5", "x": 405.50980392156913, "y": 219.5966386554621 } @@ -16649,12 +16494,10 @@ "markerEnd": "MimConversion", "points": [ { - "id": "efadd", "x": 1035.0112044817924, "y": 351.7871148459383 }, { - "id": 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your comment here" } ], "drawAs": "rect", @@ -20251,8 +20090,10 @@ "SB431542", "Wikidata:Q7388913", "ChEBI:91108", - "ChEBI:91108", - "InChI:FHYUGAJXYORMHI-UHFFFAOYSA-N" + "InChI:FHYUGAJXYORMHI-UHFFFAOYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -20412,7 +20253,6 @@ 0.25 ] }, - "id": "fd0bf", "isAttachedTo": "dfe8e", "orientation": [ -1, @@ -20422,7 +20262,6 @@ "y": 689.1666666666667 }, { - "id": "b2f5d", "x": 482, "y": 523.1643239625167 }, @@ -20438,7 +20277,6 @@ 0 ] }, - "id": "ca50c", "isAttachedTo": "d29be", "orientation": [ 1, @@ -20876,41 +20714,6 @@ "y": 589.8823529411768, "zIndex": 37040 }, - "e8139": { - "contains": [ - "c45f7", - "bb901", - "dc143", - "e50f3", - "a2417", - "d33c9", - "dc9e0", - "fbdac" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 89, - "id": "e8139", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - 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"InChI:SHGAZHPCJJPHSC-YCNIQYBTSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -25022,12 +24879,10 @@ "kaavioType": "Edge", "points": [ { - "id": "fa15c", "x": 963, "y": 757 }, { - "id": "c5133", "x": 1747, "y": 756.9999999999999 } @@ -25069,8 +24924,10 @@ "Cyclopamine", "Wikidata:Q3271319", "ChEBI:4021", - "ChEBI:4021", - "InChI:QASFUMOKHFSJGL-LAFRSMQTSA-N" + "InChI:QASFUMOKHFSJGL-LAFRSMQTSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -25164,9 +25021,6 @@ "comments": [ { "content": "http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5311272&loc=ec_rcs" - }, - { - "content": "Type your comment here" } ], "drawAs": "rect", @@ -25197,8 +25051,9 @@ "DAPT", "Wikidata:Q27158972", "ChEBI:86193", - "ChEBI:86193", - "InChI:DWJXYEABWRJFSP-XOBRGWDASA-N" + "InChI:DWJXYEABWRJFSP-XOBRGWDASA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -25402,7 +25257,6 @@ 1 ] }, - "id": "e7cdd", "isAttachedTo": "db90c", 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acid", "ChEBI:15367", - "ChEBI:15367", - "InChI:SHGAZHPCJJPHSC-YCNIQYBTSA-N" + "InChI:SHGAZHPCJJPHSC-YCNIQYBTSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -26761,7 +26611,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "fd6cc", - "isPartOf": "c55ed", + "isPartOf": "f5689", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -26836,7 +26686,6 @@ "markerEnd": "MimConversion", "points": [ { - "id": "d4e8a", "x": 906.9159663865555, "y": 677 }, @@ -26851,7 +26700,6 @@ 1 ] }, - "id": "d214c", "isAttachedTo": "ece63", "orientation": [ 0, @@ -26940,42 +26788,34 @@ "markerEnd": "MimBinding", "points": [ { - "id": "bb9f7", "x": 1104, "y": 877 }, { - "id": "d16b2", "x": 1105, "y": 950 }, { - "id": "f35e3", "x": 1153.5, "y": 950 }, { - "id": "ce8ce", "x": 1153.5, "y": 1054.5 }, { - "id": "fa0dc", "x": 1359, "y": 1055 }, { - "id": "c2ede", "x": 1359, "y": 1185 }, { - "id": "dacb8", "x": 1412.5, "y": 1185 }, { - "id": "fa06d", 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90f05fdaf..e20326e37 100644 --- a/pathways/WP3246/WP3246-datanodes.tsv +++ b/pathways/WP3246/WP3246-datanodes.tsv @@ -1,86 +1,45 @@ -Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI -GTP Metabolite hmdb:HMDB0001440 chebi:16497;chebi:16497 inchikey:HAAZLUGHYHWQIW-KVQBGUIXSA-N -L-Arginine Metabolite hmdb:HMDB0000517 chebi:16467;chebi:16467 inchikey:ODKSFYDXXFIFQN-BYPYZUCNSA-N -K+ Metabolite hmdb:HMDB0000586 chebi:29103;chebi:29103 inchikey:NPYPAHLBTDXSSS-UHFFFAOYSA-N -cGMP Metabolite hmdb:HMDB0001314 chebi:16356;chebi:16356 inchikey:ZOOGRGPOEVQQDX-UUOKFMHZSA-N -K+ Metabolite hmdb:HMDB0000586 chebi:29103;chebi:29103 inchikey:NPYPAHLBTDXSSS-UHFFFAOYSA-N -NO Metabolite hmdb:HMDB0003378 chebi:16480;chebi:16480 inchikey:MWUXSHHQAYIFBG-UHFFFAOYSA-N -ATP Metabolite hmdb:HMDB0001532 chebi:16284;chebi:16284 inchikey:SUYVUBYJARFZHO-RRKCRQDMSA-N -cAMP Metabolite hmdb:HMDB0000058 chebi:17489;chebi:17489 inchikey:IVOMOUWHDPKRLL-KQYNXXCUSA-N -Citrulline Metabolite hmdb:HMDB0000904 chebi:16349;chebi:16349 inchikey:RHGKLRLOHDJJDR-BYPYZUCNSA-N -Arachidonic acid Metabolite hmdb:HMDB0001043 chebi:15843;chebi:15843 inchikey:YZXBAPSDXZZRGB-DOFZRALJSA-N -IP3 Metabolite hmdb:HMDB0001059 chebi:16783;chebi:16783 inchikey:CIPFCGZLFXVXBG-CNWJWELYSA-N -DAG Metabolite hmdb:HMDB0007008 chebi:80651;chebi:80651 inchikey:JFBCSFJKETUREV-LJAQVGFWSA-N -Ca2+ Metabolite hmdb:HMDB0000464 chebi:29108;chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N -PIP2 Metabolite hmdb:HMDB0010032 inchikey:HKWJHKSHEWVOSS-ADCMPYHFSA-N -Ca2+ Metabolite hmdb:HMDB0000464 chebi:29108;chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N -Ca2+ Metabolite hmdb:HMDB0000464 chebi:29108;chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N -PIP2 Metabolite hmdb:HMDB0010032 inchikey:HKWJHKSHEWVOSS-ADCMPYHFSA-N -IP3 Metabolite hmdb:HMDB0001059 chebi:16783;chebi:16783 inchikey:CIPFCGZLFXVXBG-CNWJWELYSA-N -DAG Metabolite hmdb:HMDB0007008 chebi:80651;chebi:80651 inchikey:JFBCSFJKETUREV-LJAQVGFWSA-N -Ca2+ Metabolite hmdb:HMDB0000464 chebi:29108;chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N -Ca2+ Metabolite hmdb:HMDB0000464 chebi:29108;chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N -NO Metabolite hmdb:HMDB0003378 chebi:16480;chebi:16480 inchikey:MWUXSHHQAYIFBG-UHFFFAOYSA-N -Ca2+ Metabolite hmdb:HMDB0000464 chebi:29108;chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N -K+ Metabolite hmdb:HMDB0000586 chebi:29103;chebi:29103 inchikey:NPYPAHLBTDXSSS-UHFFFAOYSA-N -K+ Metabolite hmdb:HMDB0000586 chebi:29103;chebi:29103 inchikey:NPYPAHLBTDXSSS-UHFFFAOYSA-N -K+ Metabolite hmdb:HMDB0000586 chebi:29103;chebi:29103 inchikey:NPYPAHLBTDXSSS-UHFFFAOYSA-N -K+ Metabolite hmdb:HMDB0000586 chebi:29103;chebi:29103 inchikey:NPYPAHLBTDXSSS-UHFFFAOYSA-N -NO Metabolite hmdb:HMDB0003378 chebi:16480;chebi:16480 inchikey:MWUXSHHQAYIFBG-UHFFFAOYSA-N -NO Metabolite hmdb:HMDB0003378 chebi:16480;chebi:16480 inchikey:MWUXSHHQAYIFBG-UHFFFAOYSA-N -Ca2+ Metabolite hmdb:HMDB0000464 chebi:29108;chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N -RAMP1 GeneProduct ensembl:ENSBTAG00000011534 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132329 ensembl:ENSBTAG00000011534 ncbigene:617017 uniprot:A0A3Q1MKE6;uniprot:F1MLY6 -NPY1R GeneProduct ensembl:ENSBTAG00000047586 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164128 ensembl:ENSBTAG00000047586 ncbigene:504813 uniprot:Q1RMU8 -CT GeneProduct ensembl:ENSBTAG00000047380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110680 ensembl:ENSBTAG00000047380 ncbigene:514876 uniprot:A0A3Q1LVS9;uniprot:B5UBG1 -ATP2A2 GeneProduct ensembl:ENSBTAG00000001398 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174437 ensembl:ENSBTAG00000001398 ncbigene:540568 uniprot:F1MPR3;uniprot:A0A3Q1M9U0;uniprot:A0A3Q1LWF3;uniprot:A0A3Q1N8S4 -RIIAD1 GeneProduct ensembl:ENSBTAG00000032733 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000178796 ensembl:ENSBTAG00000032733 -ADCY10 GeneProduct ensembl:ENSBTAG00000001052 adenylate cyclase
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143199 ensembl:ENSBTAG00000001052 uniprot:E1B9W6 -COII GeneProduct ensembl:ENSBTAG00000043556 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4513 ensembl:ENSBTAG00000043556 ncbigene:3283880 uniprot:Q6QTG8;uniprot:P68530;uniprot:Q7JAT3 -ADRA1A GeneProduct ensembl:ENSBTAG00000031632 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120907 ensembl:ENSBTAG00000031632 ncbigene:282134 uniprot:A0A3Q1MMS4;uniprot:A0A3Q1MAT2;uniprot:A0A3Q1M6R1;uniprot:A0A3Q1MF45;uniprot:F1MYI6 -NPY GeneProduct ensembl:ENSBTAG00000004503 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122585 ensembl:ENSBTAG00000004503 ncbigene:504216 uniprot:Q6RUW3;uniprot:A0A3Q1MLV5;uniprot:B5M4A4 -CALCRL GeneProduct ensembl:ENSBTAG00000008483 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064989 ensembl:ENSBTAG00000008483 ncbigene:527140 uniprot:G3X6P6 -PTGIR GeneProduct ensembl:ENSBTAG00000014585 Prostaglandin I2 Receptor
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160013 ensembl:ENSBTAG00000014585 ncbigene:520278 uniprot:E1BQ27 -NOS3 GeneProduct ensembl:ENSBTAG00000017680 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164867 ensembl:ENSBTAG00000017680 ncbigene:287024 uniprot:A0A3Q1LSD1;uniprot:F1MY54 -EDN1 GeneProduct ensembl:ENSBTAG00000008096 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078401 ensembl:ENSBTAG00000008096 ncbigene:281137 uniprot:P17322 -ECE1 GeneProduct ensembl:ENSBTAG00000002977 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117298 ensembl:ENSBTAG00000002977 ncbigene:281133 uniprot:A0A3Q1NG29;uniprot:F1N6J1;uniprot:G3N1D0;uniprot:A0A3Q1M0N7;uniprot:A0A3Q1MWP2;uniprot:P42891;uniprot:A0A3Q1MDU6 -CNN1 GeneProduct ensembl:ENSBTAG00000011207 Calponin; tonically inhibits the ATPase activity of myosin in smooth muscle
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HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130176 ensembl:ENSBTAG00000011207 ncbigene:534583 uniprot:Q2HJ38 -PRKCA GeneProduct ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229 ensembl:ENSBTAG00000001061 ncbigene:282001 uniprot:F1MJX9;uniprot:A0A3Q1MB84;uniprot:A0A3Q1MQ80 -GNA15 GeneProduct ensembl:ENSBTAG00000019988 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000060558 ensembl:ENSBTAG00000019988 ncbigene:532029 uniprot:F1N2V3 -MYL1 GeneProduct ensembl:ENSBTAG00000009707 myosine light chain
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168530 ensembl:ENSBTAG00000009707 ncbigene:317657 uniprot:A0JNJ5 -MAP2K1 GeneProduct ensembl:ENSBTAG00000033983 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169032 ensembl:ENSBTAG00000033983 ncbigene:533199 uniprot:Q0VD16 -EDNRA GeneProduct ensembl:ENSBTAG00000013674 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151617 ensembl:ENSBTAG00000013674 ncbigene:281749 uniprot:P21450 -MYLK GeneProduct ensembl:ENSBTAG00000014567 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065534 ensembl:ENSBTAG00000014567 ncbigene:338037 uniprot:Q28824;uniprot:F1N269 -MAPK1 GeneProduct ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030 ensembl:ENSBTAG00000010312 ncbigene:327672 uniprot:P46196 -EDNRB GeneProduct ensembl:ENSBTAG00000005299 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136160 ensembl:ENSBTAG00000005299 ncbigene:281750 uniprot:P28088 -RAF1 GeneProduct ensembl:ENSBTAG00000045748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132155 ensembl:ENSBTAG00000045748 ncbigene:521196 uniprot:A7E3S4 -PLCB1 GeneProduct ensembl:ENSBTAG00000008338 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182621 ensembl:ENSBTAG00000008338 ncbigene:287026 uniprot:A0A3Q1LRN9;uniprot:A0A3Q1LIA6;uniprot:A0A3Q1NG00;uniprot:P10894 -CAD GeneProduct ensembl:ENSBTAG00000017894 Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contraction
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HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000084774 ensembl:ENSBTAG00000017894 ncbigene:504261 uniprot:F1MVC0 -EDN1 GeneProduct ensembl:ENSBTAG00000008096 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078401 ensembl:ENSBTAG00000008096 ncbigene:281137 uniprot:P17322 -GNB5 GeneProduct ensembl:ENSBTAG00000003762 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 ensembl:ENSBTAG00000003762 ncbigene:535365 uniprot:A0A3S5ZPL0;uniprot:A0A3Q1MBA5 -GNG13 GeneProduct ensembl:ENSBTAG00000033526 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 ensembl:ENSBTAG00000033526 ncbigene:517006 uniprot:E1B8Q3;uniprot:M5FMW0 -EDNRB GeneProduct ensembl:ENSBTAG00000005299 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136160 ensembl:ENSBTAG00000005299 ncbigene:281750 uniprot:P28088 -GNA15 GeneProduct ensembl:ENSBTAG00000019988 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000060558 ensembl:ENSBTAG00000019988 ncbigene:532029 uniprot:F1N2V3 -GNB5 GeneProduct ensembl:ENSBTAG00000003762 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 ensembl:ENSBTAG00000003762 ncbigene:535365 uniprot:A0A3S5ZPL0;uniprot:A0A3Q1MBA5 -GNG13 GeneProduct ensembl:ENSBTAG00000033526 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 ensembl:ENSBTAG00000033526 ncbigene:517006 uniprot:E1B8Q3;uniprot:M5FMW0 -PLCB1 GeneProduct ensembl:ENSBTAG00000008338 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182621 ensembl:ENSBTAG00000008338 ncbigene:287026 uniprot:A0A3Q1LRN9;uniprot:A0A3Q1LIA6;uniprot:A0A3Q1NG00;uniprot:P10894 -PRKCA GeneProduct ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229 ensembl:ENSBTAG00000001061 ncbigene:282001 uniprot:F1MJX9;uniprot:A0A3Q1MB84;uniprot:A0A3Q1MQ80 -GNAS GeneProduct ensembl:ENSBTAG00000017475 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087460 ensembl:ENSBTAG00000017475 uniprot:G1K1V2 -GNB5 GeneProduct ensembl:ENSBTAG00000003762 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 ensembl:ENSBTAG00000003762 ncbigene:535365 uniprot:A0A3S5ZPL0;uniprot:A0A3Q1MBA5 -GNG13 GeneProduct ensembl:ENSBTAG00000033526 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 ensembl:ENSBTAG00000033526 ncbigene:517006 uniprot:E1B8Q3;uniprot:M5FMW0 -GNA15 GeneProduct ensembl:ENSBTAG00000019988 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000060558 ensembl:ENSBTAG00000019988 ncbigene:532029 uniprot:F1N2V3 -GNB5 GeneProduct ensembl:ENSBTAG00000003762 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 ensembl:ENSBTAG00000003762 ncbigene:535365 uniprot:A0A3S5ZPL0;uniprot:A0A3Q1MBA5 -GNG13 GeneProduct ensembl:ENSBTAG00000033526 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 ensembl:ENSBTAG00000033526 ncbigene:517006 uniprot:E1B8Q3;uniprot:M5FMW0 -ADRB1 GeneProduct ensembl:ENSBTAG00000001242 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000043591 ensembl:ENSBTAG00000001242 ncbigene:281604 uniprot:F6R653 -GNAS GeneProduct ensembl:ENSBTAG00000017475 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087460 ensembl:ENSBTAG00000017475 uniprot:G1K1V2 -GNB5 GeneProduct ensembl:ENSBTAG00000003762 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 ensembl:ENSBTAG00000003762 ncbigene:535365 uniprot:A0A3S5ZPL0;uniprot:A0A3Q1MBA5 -GNG13 GeneProduct ensembl:ENSBTAG00000033526 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 ensembl:ENSBTAG00000033526 ncbigene:517006 uniprot:E1B8Q3;uniprot:M5FMW0 -CT GeneProduct ensembl:ENSBTAG00000047380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110680 ensembl:ENSBTAG00000047380 ncbigene:514876 uniprot:A0A3Q1LVS9;uniprot:B5UBG1 -CT GeneProduct ensembl:ENSBTAG00000047380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110680 ensembl:ENSBTAG00000047380 ncbigene:514876 uniprot:A0A3Q1LVS9;uniprot:B5UBG1 -GNAS GeneProduct ensembl:ENSBTAG00000017475 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087460 ensembl:ENSBTAG00000017475 uniprot:G1K1V2 -GNB5 GeneProduct ensembl:ENSBTAG00000003762 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 ensembl:ENSBTAG00000003762 ncbigene:535365 uniprot:A0A3S5ZPL0;uniprot:A0A3Q1MBA5 -GNG13 GeneProduct ensembl:ENSBTAG00000033526 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 ensembl:ENSBTAG00000033526 ncbigene:517006 uniprot:E1B8Q3;uniprot:M5FMW0 -NPY GeneProduct ensembl:ENSBTAG00000004503 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122585 ensembl:ENSBTAG00000004503 ncbigene:504216 uniprot:Q6RUW3;uniprot:A0A3Q1MLV5;uniprot:B5M4A4 -NPY GeneProduct ensembl:ENSBTAG00000004503 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122585 ensembl:ENSBTAG00000004503 ncbigene:504216 uniprot:Q6RUW3;uniprot:A0A3Q1MLV5;uniprot:B5M4A4 -GNAI1 GeneProduct ensembl:ENSBTAG00000002714 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127955 ensembl:ENSBTAG00000002714 ncbigene:281790 uniprot:P63097 -GNB5 GeneProduct ensembl:ENSBTAG00000003762 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966 ensembl:ENSBTAG00000003762 ncbigene:535365 uniprot:A0A3S5ZPL0;uniprot:A0A3Q1MBA5 -GNG13 GeneProduct ensembl:ENSBTAG00000033526 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588 ensembl:ENSBTAG00000033526 ncbigene:517006 uniprot:E1B8Q3;uniprot:M5FMW0 +Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps +GTP Metabolite hmdb:HMDB0001440 "" chebi:16497 inchikey:HAAZLUGHYHWQIW-KVQBGUIXSA-N pubchem.compound:65103 chemspider:58613 hmdb:HMDB0001440 kegg.compound:C00286 +L-Arginine Metabolite hmdb:HMDB0000517 "" chebi:16467 inchikey:ODKSFYDXXFIFQN-BYPYZUCNSA-N pubchem.compound:6322 chemspider:6082 hmdb:HMDB0000517 kegg.compound:C00062 +K+ Metabolite hmdb:HMDB0000586 "" chebi:29103 inchikey:NPYPAHLBTDXSSS-UHFFFAOYSA-N pubchem.compound:813 hmdb:HMDB0000586 kegg.compound:C00238 +cGMP Metabolite hmdb:HMDB0001314 "" chebi:16356 inchikey:ZOOGRGPOEVQQDX-UUOKFMHZSA-N pubchem.compound:24316 chemspider:22734 hmdb:HMDB0001314 kegg.compound:C00942 +NO Metabolite hmdb:HMDB0003378 "" chebi:16480 inchikey:MWUXSHHQAYIFBG-UHFFFAOYSA-N pubchem.compound:145068 chemspider:127983 hmdb:HMDB0003378 kegg.compound:C00533 +ATP Metabolite hmdb:HMDB0001532 "" chebi:16284 inchikey:SUYVUBYJARFZHO-RRKCRQDMSA-N pubchem.compound:15993 chemspider:15194 hmdb:HMDB0001532 kegg.compound:C00131 +cAMP Metabolite hmdb:HMDB0000058 "" chebi:17489 inchikey:IVOMOUWHDPKRLL-KQYNXXCUSA-N pubchem.compound:6076 chemspider:5851 hmdb:HMDB0000058 kegg.compound:C00575 +Citrulline Metabolite hmdb:HMDB0000904 "" chebi:16349 inchikey:RHGKLRLOHDJJDR-BYPYZUCNSA-N pubchem.compound:9750 chemspider:9367 hmdb:HMDB0000904 kegg.compound:C00327 +Arachidonic acid Metabolite hmdb:HMDB0001043 "" chebi:15843 inchikey:YZXBAPSDXZZRGB-DOFZRALJSA-N pubchem.compound:444899 chemspider:392692 hmdb:HMDB0001043 kegg.compound:C00219 +IP3 Metabolite hmdb:HMDB0001059 "" chebi:16783 inchikey:CIPFCGZLFXVXBG-CNWJWELYSA-N pubchem.compound:107758 chemspider:17216047 hmdb:HMDB0001059 kegg.compound:C01272 +DAG Metabolite hmdb:HMDB0007008 "" chebi:80651 inchikey:JFBCSFJKETUREV-LJAQVGFWSA-N pubchem.compound:10369168 chemspider:8544614 hmdb:HMDB0007008 kegg.compound:C16667 +Ca2+ Metabolite hmdb:HMDB0000464 "" chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N pubchem.compound:271 chemspider:266 hmdb:HMDB0000464 kegg.compound:C00076 +PIP2 Metabolite hmdb:HMDB0010032 "" inchikey:HKWJHKSHEWVOSS-ADCMPYHFSA-N pubchem.compound:53480223 chemspider:24767909 hmdb:HMDB0010032 +RAMP1 GeneProduct ensembl:ENSBTAG00000011534 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132329" ensembl:ENSBTAG00000011534 ncbigene:617017 uniprot:A0A3Q1MKE6;uniprot:F1MLY6 +NPY1R GeneProduct ensembl:ENSBTAG00000047586 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164128" ensembl:ENSBTAG00000047586 ncbigene:504813 uniprot:Q1RMU8 +CT GeneProduct ensembl:ENSBTAG00000047380 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110680" ensembl:ENSBTAG00000047380 ncbigene:514876 uniprot:A0A3Q1LVS9;uniprot:B5UBG1 +ATP2A2 GeneProduct ensembl:ENSBTAG00000001398 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174437" ensembl:ENSBTAG00000001398 ncbigene:540568 uniprot:F1MPR3;uniprot:A0A3Q1M9U0;uniprot:A0A3Q1LWF3;uniprot:A0A3Q1N8S4 +RIIAD1 GeneProduct ensembl:ENSBTAG00000032733 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000178796" ensembl:ENSBTAG00000032733 +ADCY10 GeneProduct ensembl:ENSBTAG00000001052 "adenylate cyclase
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143199" ensembl:ENSBTAG00000001052 uniprot:E1B9W6 +COII GeneProduct ensembl:ENSBTAG00000043556 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4513" ensembl:ENSBTAG00000043556 ncbigene:3283880 uniprot:Q6QTG8;uniprot:P68530;uniprot:Q7JAT3 +ADRA1A GeneProduct ensembl:ENSBTAG00000031632 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120907" ensembl:ENSBTAG00000031632 ncbigene:282134 uniprot:A0A3Q1MMS4;uniprot:A0A3Q1MAT2;uniprot:A0A3Q1M6R1;uniprot:A0A3Q1MF45;uniprot:F1MYI6 +NPY GeneProduct ensembl:ENSBTAG00000004503 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122585" ensembl:ENSBTAG00000004503 ncbigene:504216 uniprot:Q6RUW3;uniprot:A0A3Q1MLV5;uniprot:B5M4A4 +CALCRL GeneProduct ensembl:ENSBTAG00000008483 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064989" ensembl:ENSBTAG00000008483 ncbigene:527140 uniprot:G3X6P6 +PTGIR GeneProduct ensembl:ENSBTAG00000014585 "Prostaglandin I2 Receptor
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160013" ensembl:ENSBTAG00000014585 ncbigene:520278 uniprot:E1BQ27 +NOS3 GeneProduct ensembl:ENSBTAG00000017680 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164867" ensembl:ENSBTAG00000017680 ncbigene:287024 uniprot:A0A3Q1LSD1;uniprot:F1MY54 +EDN1 GeneProduct ensembl:ENSBTAG00000008096 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078401" ensembl:ENSBTAG00000008096 ncbigene:281137 uniprot:P17322 +ECE1 GeneProduct ensembl:ENSBTAG00000002977 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117298" ensembl:ENSBTAG00000002977 ncbigene:281133 uniprot:A0A3Q1NG29;uniprot:F1N6J1;uniprot:G3N1D0;uniprot:A0A3Q1M0N7;uniprot:A0A3Q1MWP2;uniprot:P42891;uniprot:A0A3Q1MDU6 +CNN1 GeneProduct ensembl:ENSBTAG00000011207 "Calponin; tonically inhibits the ATPase activity of myosin in smooth muscle
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130176" ensembl:ENSBTAG00000011207 ncbigene:534583 uniprot:Q2HJ38 +PRKCA GeneProduct ensembl:ENSBTAG00000001061 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229" ensembl:ENSBTAG00000001061 ncbigene:282001 uniprot:F1MJX9;uniprot:A0A3Q1MB84;uniprot:A0A3Q1MQ80 +GNA15 GeneProduct ensembl:ENSBTAG00000019988 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000060558" ensembl:ENSBTAG00000019988 ncbigene:532029 uniprot:F1N2V3 +MYL1 GeneProduct ensembl:ENSBTAG00000009707 "myosine light chain
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168530" ensembl:ENSBTAG00000009707 ncbigene:317657 uniprot:A0JNJ5 +MAP2K1 GeneProduct ensembl:ENSBTAG00000033983 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169032" ensembl:ENSBTAG00000033983 ncbigene:533199 uniprot:Q0VD16 +EDNRA GeneProduct ensembl:ENSBTAG00000013674 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151617" ensembl:ENSBTAG00000013674 ncbigene:281749 uniprot:P21450 +MYLK GeneProduct ensembl:ENSBTAG00000014567 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065534" ensembl:ENSBTAG00000014567 ncbigene:338037 uniprot:Q28824;uniprot:F1N269 +MAPK1 GeneProduct ensembl:ENSBTAG00000010312 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030" ensembl:ENSBTAG00000010312 ncbigene:327672 uniprot:P46196 +EDNRB GeneProduct ensembl:ENSBTAG00000005299 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136160" ensembl:ENSBTAG00000005299 ncbigene:281750 uniprot:P28088 +RAF1 GeneProduct ensembl:ENSBTAG00000045748 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132155" ensembl:ENSBTAG00000045748 ncbigene:521196 uniprot:A7E3S4 +PLCB1 GeneProduct ensembl:ENSBTAG00000008338 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182621" ensembl:ENSBTAG00000008338 ncbigene:287026 uniprot:A0A3Q1LRN9;uniprot:A0A3Q1LIA6;uniprot:A0A3Q1NG00;uniprot:P10894 +CAD GeneProduct ensembl:ENSBTAG00000017894 "Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contraction
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000084774" ensembl:ENSBTAG00000017894 ncbigene:504261 uniprot:F1MVC0 +GNB5 GeneProduct ensembl:ENSBTAG00000003762 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966" ensembl:ENSBTAG00000003762 ncbigene:535365 uniprot:A0A3S5ZPL0;uniprot:A0A3Q1MBA5 +GNG13 GeneProduct ensembl:ENSBTAG00000033526 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588" ensembl:ENSBTAG00000033526 ncbigene:517006 uniprot:E1B8Q3 +GNAS GeneProduct ensembl:ENSBTAG00000017475 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087460" ensembl:ENSBTAG00000017475 uniprot:G1K1V2 +ADRB1 GeneProduct ensembl:ENSBTAG00000001242 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000043591" ensembl:ENSBTAG00000001242 ncbigene:281604 uniprot:F6R653 +GNAI1 GeneProduct ensembl:ENSBTAG00000002714 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127955" ensembl:ENSBTAG00000002714 ncbigene:281790 uniprot:P63097 diff --git a/pathways/WP3246/WP3246.gpml b/pathways/WP3246/WP3246.gpml index 55cb907e6..3c9b0cb96 100644 --- a/pathways/WP3246/WP3246.gpml +++ b/pathways/WP3246/WP3246.gpml @@ -1,5 +1,5 @@ - + Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation. This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP2197_r74852 WP2197(74852)] with a 79.0% conversion rate. @@ -145,7 +145,6 @@ Calponin; tonically inhibits the ATPase activity of myosin in smooth muscle - Type your comment here HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130176 @@ -161,7 +160,7 @@ - myosine light chain + myosine light chain HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168530 @@ -217,13 +216,12 @@ - + Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contraction - Type your comment here HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000084774 @@ -471,208 +469,208 @@ - - + + - - + + inhibition by phosphorylation and thereby preventing association with CaM - - + + - - + + - - - + + + - - + + - - - + + + - - + + - - + + - - + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - - + + + + - - + + - - + + @@ -680,538 +678,535 @@ - - + + - - + + - - - + + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + Inhibition by phosphorylation - Type your comment here - - + + - - + + - - + + stimulation by phosphorylation - Type your comment here - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + Inhibition by phosphorylation - Type your comment here - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + @@ -1301,49 +1296,54 @@ - - - - - - - + + + + + + + - hypertension - DOID:10763 - Human Disease Ontology + G protein mediated signaling pathway via Galphai family + PW:0000228 + Pathway Ontology + + + calcium/calmodulin dependent signaling pathway + PW:0000314 + Pathway Ontology + + + G protein mediated signaling pathway via Galphas family + PW:0000227 + Pathway Ontology benign essential hypertension DOID:10913 - Human Disease Ontology + Disease smooth muscle cell CL:0000192 - Cell Ontology - - - blood vessel endothelial cell - CL:0000071 - Cell Ontology + Cell Type - calcium/calmodulin dependent signaling pathway - PW:0000314 - Pathway Ontology + hypertension + DOID:10763 + Disease - G protein mediated signaling pathway via Galphai family - PW:0000228 + endothelin signaling pathway + PW:0000506 Pathway Ontology - G protein mediated signaling pathway via Galphas family - PW:0000227 - Pathway Ontology + blood vessel endothelial cell + CL:0000071 + Cell Type Ras superfamily mediated signaling pathway @@ -1355,10 +1355,6 @@ PW:0000229 Pathway Ontology - - endothelin signaling pathway - PW:0000506 - Pathway Ontology - + diff --git a/pathways/WP3246/WP3246.json b/pathways/WP3246/WP3246.json index 05a217c58..1a15e9752 100644 --- a/pathways/WP3246/WP3246.json +++ b/pathways/WP3246/WP3246.json @@ -1,93 +1,5 @@ { "entitiesById": { - "324567": { - "__HighlandStream__": true, - "_can_drain": false, - "_consume_waiting_for_next": false, - "_consumers": [], - "_delegate": null, - "_destructors": [], - "_events": {}, - "_eventsCount": 2, - "_in_consume_cb": false, - "_incoming": [], - "_is_observer": false, - "_nil_pushed": false, - "_observers": [], - "_outgoing": [], - "_repeat_resume": false, - "_send_events": false, - "id": "324567", - "paused": true, - "source": null, - "writable": true - }, - "327799": { - "__HighlandStream__": true, - "_can_drain": false, - "_consume_waiting_for_next": false, - "_consumers": [], - "_delegate": null, - "_destructors": [], - "_events": {}, - "_eventsCount": 2, - "_in_consume_cb": false, - "_incoming": [], - "_is_observer": false, - "_nil_pushed": false, - "_observers": [], - "_outgoing": [], - "_repeat_resume": false, - "_send_events": false, - "id": "327799", - "paused": true, - "source": null, - "writable": true - }, - "417782": { - "__HighlandStream__": true, - "_can_drain": false, - "_consume_waiting_for_next": false, - "_consumers": [], - "_delegate": null, - "_destructors": [], - "_events": {}, - "_eventsCount": 2, - "_in_consume_cb": false, - "_incoming": [], - "_is_observer": false, - "_nil_pushed": false, - "_observers": [], - "_outgoing": [], - "_repeat_resume": false, - "_send_events": false, - "id": "417782", - "paused": true, - "source": null, - "writable": true - }, - "882148": { - "__HighlandStream__": true, - "_can_drain": false, - "_consume_waiting_for_next": false, - "_consumers": [], - "_delegate": null, - "_destructors": [], - "_events": {}, - "_eventsCount": 2, - "_in_consume_cb": false, - "_incoming": [], - "_is_observer": false, - "_nil_pushed": false, - "_observers": [], - "_outgoing": [], - "_repeat_resume": false, - "_send_events": false, - "id": "882148", - "paused": true, - "source": null, - "writable": true - }, "a07bf": { "comments": [ { @@ -104,7 +16,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a07bf", - "isPartOf": "e7d54", + "isPartOf": "c18cd", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -489,11 +401,11 @@ "y": 1452.3046213790676, "zIndex": 32890 }, - "a9e08": { + "a856b": { "contains": [ - "f36f9", - "cf15f", - "d883f" + "e1a64", + "bfe3e", + "eb667" ], "drawAs": "none", "fill": "transparent", @@ -501,8 +413,8 @@ "fontSize": 1, "fontWeight": "bold", "gpmlElementName": "Group", - "height": 76.00000000000068, - "id": "a9e08", + "height": 76.00000000000011, + "id": "a856b", "kaavioType": "Group", "padding": 8, "stroke": "#808080", @@ -514,10 +426,10 @@ "GroupGroup" ], "verticalAlign": "middle", - "width": 96.00000000000091, - "x": 1591.476735872357, - "y": 948.3525469714955, - "zIndex": 32877 + "width": 96.00000000000006, + "x": 345.56585775392074, + "y": 705.9932523188667, + "zIndex": 32780 }, "aa3af": { "drawAs": "rect", @@ -568,7 +480,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "abe76", - "isPartOf": "e1eb3", + "isPartOf": "c0f4f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -616,7 +528,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "acb2a", - "isPartOf": "c2bb1", + "isPartOf": "ec60e", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -676,8 +588,11 @@ "CompactIdentifier:hmdb:HMDB0001059", "IP3", "ChEBI:16783", - "ChEBI:16783", - "InChI:CIPFCGZLFXVXBG-CNWJWELYSA-N" + "InChI:CIPFCGZLFXVXBG-CNWJWELYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -765,8 +680,11 @@ "CompactIdentifier:hmdb:HMDB0000464", "Ca2+", "ChEBI:29108", - "ChEBI:29108", - "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N" + "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -787,12 +705,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "cf58a", "x": 1082.6651975344093, "y": 1468.4721024560067 }, { - "id": "a115f", "x": 1082.0478426112204, "y": 1520.2325061479992 } @@ -837,7 +753,10 @@ "Metabolite", "CompactIdentifier:hmdb:HMDB0010032", "PIP2", - "InChI:HKWJHKSHEWVOSS-ADCMPYHFSA-N" + "InChI:HKWJHKSHEWVOSS-ADCMPYHFSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -877,8 +796,11 @@ "CompactIdentifier:hmdb:HMDB0000464", "Ca2+", "ChEBI:29108", - "ChEBI:29108", - "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N" + "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -937,36 +859,6 @@ "y": 930.7778749999999, "zIndex": 32786 }, - "b14fe": { - "contains": [ - "e1a64", - "bfe3e", - "eb667" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 76.00000000000011, - "id": "b14fe", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 96.00000000000006, - "x": 345.56585775392074, - "y": 705.9932523188667, - "zIndex": 32780 - }, "b19b8": { "drawAs": "rect", "fill": "#ffffff", @@ -1028,8 +920,10 @@ "CompactIdentifier:hmdb:HMDB0000586", "K+", "ChEBI:29103", - "ChEBI:29103", - "InChI:NPYPAHLBTDXSSS-UHFFFAOYSA-N" + "InChI:NPYPAHLBTDXSSS-UHFFFAOYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1151,7 +1045,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b3e23", - "isPartOf": "ee21f", + "isPartOf": "fb7e4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1332,7 +1226,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "b6e0d", - "isPartOf": "e1eb3", + "isPartOf": "c0f4f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1352,8 +1246,7 @@ "GNG13", "Ensembl:ENSBTAG00000033526", "Entrez Gene:517006", - "UniProt:E1B8Q3", - "UniProt:M5FMW0" + "UniProt:E1B8Q3" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1393,8 +1286,11 @@ "CompactIdentifier:hmdb:HMDB0000464", "Ca2+", "ChEBI:29108", - "ChEBI:29108", - "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N" + "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1434,8 +1330,11 @@ "CompactIdentifier:hmdb:HMDB0001440", "GTP", "ChEBI:16497", - "ChEBI:16497", - "InChI:HAAZLUGHYHWQIW-KVQBGUIXSA-N" + "InChI:HAAZLUGHYHWQIW-KVQBGUIXSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1470,12 +1369,12 @@ "type": [ "DataNode", "SingleFreeNode", - "RNA" + "Rna" ], "verticalAlign": "middle", "whiteSpace": "pre", "width": 80, - "wpType": "RNA", + "wpType": "Rna", "x": 300.34174999999965, "y": 126.59975000000006, "zIndex": 32806 @@ -1642,7 +1541,6 @@ 0 ] }, - "id": "bb69a", "isAttachedTo": "e5c29", "orientation": [], "x": 1082.7703363035344, @@ -1659,7 +1557,6 @@ 0.25 ] }, - "id": "a64e0", "isAttachedTo": "cdd88", "orientation": [ 1, @@ -1705,8 +1602,11 @@ "CompactIdentifier:hmdb:HMDB0003378", "NO", "ChEBI:16480", - "ChEBI:16480", - "InChI:MWUXSHHQAYIFBG-UHFFFAOYSA-N" + "InChI:MWUXSHHQAYIFBG-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1759,7 +1659,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "bfe3e", - "isPartOf": "b14fe", + "isPartOf": "a856b", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1792,6 +1692,36 @@ "y": 28.000000000000114, "zIndex": 32820 }, + "bffb7": { + "contains": [ + "fb9d6", + "e500e", + "e6407" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 76.00000000000028, + "id": "bffb7", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 96, + "x": 493.87840558832863, + "y": 435.34387745059473, + "zIndex": 32842 + }, "c036f": { "comments": [ { @@ -1862,6 +1792,66 @@ "width": 0, "zIndex": 12288 }, + "c0f4f": { + "contains": [ + "abe76", + "f712d", + "b6e0d" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 76.0000000000008, + "id": "c0f4f", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 96.00000000000159, + "x": 835.3076218116039, + "y": 627.3542095196925, + "zIndex": 32872 + }, + "c18cd": { + "contains": [ + "a07bf", + "ef888", + "ce426" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 76.00000000000023, + "id": "c18cd", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 96.00000000000091, + "x": 1389.649226666435, + "y": 1223.4259158840398, + "zIndex": 32892 + }, "c1b78": { "comments": [ { @@ -1945,11 +1935,11 @@ "y": 777.383399413868, "zIndex": 32826 }, - "c2bb1": { + "c2b49": { "contains": [ - "acb2a", - "f9cd2", - "da6af" + "f36f9", + "cf15f", + "d883f" ], "drawAs": "none", "fill": "transparent", @@ -1957,8 +1947,8 @@ "fontSize": 1, "fontWeight": "bold", "gpmlElementName": "Group", - "height": 76.00000000000091, - "id": "c2bb1", + "height": 76.00000000000068, + "id": "c2b49", "kaavioType": "Group", "padding": 8, "stroke": "#808080", @@ -1971,9 +1961,9 @@ ], "verticalAlign": "middle", "width": 96.00000000000091, - "x": 1534.926526564924, - "y": 1118.234510990174, - "zIndex": 32901 + "x": 1591.476735872357, + "y": 948.3525469714955, + "zIndex": 32877 }, "c32c0": { "attachmentDisplay": { @@ -2005,9 +1995,6 @@ { "content": "Calponin; tonically inhibits the ATPase activity of myosin in smooth muscle" }, - { - "content": "Type your comment here" - }, { "content": "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130176", "source": "HomologyConvert" @@ -2081,8 +2068,11 @@ "CompactIdentifier:hmdb:HMDB0000464", "Ca2+", "ChEBI:29108", - "ChEBI:29108", - "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N" + "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2205,12 +2195,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "b9837", "x": 1096.4977164574732, "y": 1468.1594095959686 }, { - "id": "c39b6", "x": 1096.4977164574732, "y": 1520.5371682111518 } @@ -2285,12 +2273,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "c5bbc", "x": 1070.1101849190356, "y": 1468.1594081905812 }, { - "id": "ef358", "x": 1070.1101849190356, "y": 1520.5371668057644 } @@ -2336,8 +2322,11 @@ "CompactIdentifier:hmdb:HMDB0000517", "L-Arginine", "ChEBI:16467", - "ChEBI:16467", - "InChI:ODKSFYDXXFIFQN-BYPYZUCNSA-N" + "InChI:ODKSFYDXXFIFQN-BYPYZUCNSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2365,7 +2354,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "c8e52", - "isPartOf": "ee21f", + "isPartOf": "fb7e4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2385,8 +2374,7 @@ "GNG13", "Ensembl:ENSBTAG00000033526", "Entrez Gene:517006", - "UniProt:E1B8Q3", - "UniProt:M5FMW0" + "UniProt:E1B8Q3" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2523,7 +2511,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "ce426", - "isPartOf": "e7d54", + "isPartOf": "c18cd", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2543,8 +2531,7 @@ "GNG13", "Ensembl:ENSBTAG00000033526", "Entrez Gene:517006", - "UniProt:E1B8Q3", - "UniProt:M5FMW0" + "UniProt:E1B8Q3" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2572,7 +2559,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "cf15f", - "isPartOf": "a9e08", + "isPartOf": "c2b49", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2691,8 +2678,10 @@ "CompactIdentifier:hmdb:HMDB0000586", "K+", "ChEBI:29103", - "ChEBI:29103", - "InChI:NPYPAHLBTDXSSS-UHFFFAOYSA-N" + "InChI:NPYPAHLBTDXSSS-UHFFFAOYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2732,8 +2721,11 @@ "CompactIdentifier:hmdb:HMDB0001059", "IP3", "ChEBI:16783", - "ChEBI:16783", - "InChI:CIPFCGZLFXVXBG-CNWJWELYSA-N" + "InChI:CIPFCGZLFXVXBG-CNWJWELYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2745,36 +2737,6 @@ "y": 361.25550394771864, "zIndex": 32847 }, - "d0edd": { - "contains": [ - "fb9d6", - "e500e", - "e6407" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 76.00000000000028, - "id": "d0edd", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 96, - "x": 493.87840558832863, - "y": 435.34387745059473, - "zIndex": 32842 - }, "d16ab": { "drawAs": "none", "fill": "transparent", @@ -2916,8 +2878,11 @@ "CompactIdentifier:hmdb:HMDB0003378", "NO", "ChEBI:16480", - "ChEBI:16480", - "InChI:MWUXSHHQAYIFBG-UHFFFAOYSA-N" + "InChI:MWUXSHHQAYIFBG-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3115,12 +3080,10 @@ "kaavioType": "Edge", "points": [ { - "id": "d3c8c", "x": 401.2772500000001, "y": 1271.072268554687 }, { - "id": "a3946", "x": 525.1431249999996, "y": 1271.072268554687 } @@ -3161,8 +3124,11 @@ "CompactIdentifier:hmdb:HMDB0001314", "cGMP", "ChEBI:16356", - "ChEBI:16356", - "InChI:ZOOGRGPOEVQQDX-UUOKFMHZSA-N" + "InChI:ZOOGRGPOEVQQDX-UUOKFMHZSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3190,7 +3156,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "d7585", - "isPartOf": "ee21f", + "isPartOf": "fb7e4", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3239,7 +3205,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "d883f", - "isPartOf": "a9e08", + "isPartOf": "c2b49", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3259,8 +3225,7 @@ "GNG13", "Ensembl:ENSBTAG00000033526", "Entrez Gene:517006", - "UniProt:E1B8Q3", - "UniProt:M5FMW0" + "UniProt:E1B8Q3" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3300,8 +3265,10 @@ "CompactIdentifier:hmdb:HMDB0000586", "K+", "ChEBI:29103", - "ChEBI:29103", - "InChI:NPYPAHLBTDXSSS-UHFFFAOYSA-N" + "InChI:NPYPAHLBTDXSSS-UHFFFAOYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3329,7 +3296,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "da6af", - "isPartOf": "c2bb1", + "isPartOf": "ec60e", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3349,8 +3316,7 @@ "GNG13", "Ensembl:ENSBTAG00000033526", "Entrez Gene:517006", - "UniProt:E1B8Q3", - "UniProt:M5FMW0" + "UniProt:E1B8Q3" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3370,12 +3336,10 @@ "kaavioType": "Edge", "points": [ { - "id": "e27a2", "x": 544.0837607498166, "y": 1298.4366250000007 }, { - "id": "a4993", "x": 667.9496357498166, "y": 1298.4366250000007 } @@ -3416,8 +3380,10 @@ "CompactIdentifier:hmdb:HMDB0000586", "K+", "ChEBI:29103", - "ChEBI:29103", - "InChI:NPYPAHLBTDXSSS-UHFFFAOYSA-N" + "InChI:NPYPAHLBTDXSSS-UHFFFAOYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3457,8 +3423,11 @@ "CompactIdentifier:hmdb:HMDB0003378", "NO", "ChEBI:16480", - "ChEBI:16480", - "InChI:MWUXSHHQAYIFBG-UHFFFAOYSA-N" + "InChI:MWUXSHHQAYIFBG-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3545,8 +3514,10 @@ "CompactIdentifier:hmdb:HMDB0000586", "K+", "ChEBI:29103", - "ChEBI:29103", - "InChI:NPYPAHLBTDXSSS-UHFFFAOYSA-N" + "InChI:NPYPAHLBTDXSSS-UHFFFAOYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3663,7 +3634,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e1a64", - "isPartOf": "b14fe", + "isPartOf": "a856b", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3695,36 +3666,6 @@ "y": 8, "zIndex": 32780 }, - "e1eb3": { - "contains": [ - "abe76", - "f712d", - "b6e0d" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 76.0000000000008, - "id": "e1eb3", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 96.00000000000159, - "x": 835.3076218116039, - "y": 627.3542095196925, - "zIndex": 32872 - }, "e2338": { "drawAs": "none", "fill": "transparent", @@ -3784,8 +3725,11 @@ "CompactIdentifier:hmdb:HMDB0001532", "ATP", "ChEBI:16284", - "ChEBI:16284", - "InChI:SUYVUBYJARFZHO-RRKCRQDMSA-N" + "InChI:SUYVUBYJARFZHO-RRKCRQDMSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3805,12 +3749,10 @@ "kaavioType": "Edge", "points": [ { - "id": "c2d1e", "x": 401.2772254219053, "y": 1298.4366113281253 }, { - "id": "bbfee", "x": 525.1431004219038, "y": 1298.4366113281253 } @@ -3839,7 +3781,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "e500e", - "isPartOf": "d0edd", + "isPartOf": "bffb7", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3950,8 +3892,11 @@ "CompactIdentifier:hmdb:HMDB0000058", "cAMP", "ChEBI:17489", - "ChEBI:17489", - "InChI:IVOMOUWHDPKRLL-KQYNXXCUSA-N" + "InChI:IVOMOUWHDPKRLL-KQYNXXCUSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4039,7 +3984,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "e6407", - "isPartOf": "d0edd", + "isPartOf": "bffb7", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4059,8 +4004,7 @@ "GNG13", "Ensembl:ENSBTAG00000033526", "Entrez Gene:517006", - "UniProt:E1B8Q3", - "UniProt:M5FMW0" + "UniProt:E1B8Q3" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4100,8 +4044,11 @@ "CompactIdentifier:hmdb:HMDB0000904", "Citrulline", "ChEBI:16349", - "ChEBI:16349", - "InChI:RHGKLRLOHDJJDR-BYPYZUCNSA-N" + "InChI:RHGKLRLOHDJJDR-BYPYZUCNSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4141,8 +4088,11 @@ "CompactIdentifier:hmdb:HMDB0007008", "DAG", "ChEBI:80651", - "ChEBI:80651", - "InChI:JFBCSFJKETUREV-LJAQVGFWSA-N" + "InChI:JFBCSFJKETUREV-LJAQVGFWSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4218,8 +4168,10 @@ "CompactIdentifier:hmdb:HMDB0000586", "K+", "ChEBI:29103", - "ChEBI:29103", - "InChI:NPYPAHLBTDXSSS-UHFFFAOYSA-N" + "InChI:NPYPAHLBTDXSSS-UHFFFAOYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4264,36 +4216,6 @@ "y": 1367.0567942804191, "zIndex": 32768 }, - "e7d54": { - "contains": [ - "a07bf", - "ef888", - "ce426" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 76.00000000000023, - "id": "e7d54", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 96.00000000000091, - "x": 1389.649226666435, - "y": 1223.4259158840398, - "zIndex": 32892 - }, "e87d7": { "cellularComponent": "Cell", "drawAs": "rect", @@ -4385,8 +4307,11 @@ "CompactIdentifier:hmdb:HMDB0007008", "DAG", "ChEBI:80651", - "ChEBI:80651", - "InChI:JFBCSFJKETUREV-LJAQVGFWSA-N" + "InChI:JFBCSFJKETUREV-LJAQVGFWSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4426,8 +4351,11 @@ "CompactIdentifier:hmdb:HMDB0000464", "Ca2+", "ChEBI:29108", - "ChEBI:29108", - "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N" + "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4455,7 +4383,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "eb667", - "isPartOf": "b14fe", + "isPartOf": "a856b", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4475,8 +4403,7 @@ "GNG13", "Ensembl:ENSBTAG00000033526", "Entrez Gene:517006", - "UniProt:E1B8Q3", - "UniProt:M5FMW0" + "UniProt:E1B8Q3" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4559,6 +4486,36 @@ "y": 86.50000000000011, "zIndex": 16388 }, + "ec60e": { + "contains": [ + "acb2a", + "f9cd2", + "da6af" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 76.00000000000091, + "id": "ec60e", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 96.00000000000091, + "x": 1534.926526564924, + "y": 1118.234510990174, + "zIndex": 32901 + }, "ec739": { "cellularComponent": "EndoplasmicReticulum", "drawAs": "EndoplasmicReticulum", @@ -4622,8 +4579,11 @@ "CompactIdentifier:hmdb:HMDB0003378", "NO", "ChEBI:16480", - "ChEBI:16480", - "InChI:MWUXSHHQAYIFBG-UHFFFAOYSA-N" + "InChI:MWUXSHHQAYIFBG-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4662,7 +4622,10 @@ "Metabolite", "CompactIdentifier:hmdb:HMDB0010032", "PIP2", - "InChI:HKWJHKSHEWVOSS-ADCMPYHFSA-N" + "InChI:HKWJHKSHEWVOSS-ADCMPYHFSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4674,36 +4637,6 @@ "y": 635.6560414912341, "zIndex": 32814 }, - "ee21f": { - "contains": [ - "b3e23", - "d7585", - "c8e52" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 76.00000000000045, - "id": "ee21f", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 96.00000000000091, - "x": 1327.7396162601976, - "y": 701.5420526105806, - "zIndex": 32865 - }, "eecfe": { "comments": [ { @@ -4769,7 +4702,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "ef888", - "isPartOf": "e7d54", + "isPartOf": "c18cd", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5034,8 +4967,11 @@ "CompactIdentifier:hmdb:HMDB0001043", "Arachidonic acid", "ChEBI:15843", - "ChEBI:15843", - "InChI:YZXBAPSDXZZRGB-DOFZRALJSA-N" + "InChI:YZXBAPSDXZZRGB-DOFZRALJSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5096,7 +5032,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f36f9", - "isPartOf": "a9e08", + "isPartOf": "c2b49", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5155,8 +5091,11 @@ "CompactIdentifier:hmdb:HMDB0000464", "Ca2+", "ChEBI:29108", - "ChEBI:29108", - "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N" + "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5302,12 +5241,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "ff87c", "x": 1056.277665995974, "y": 1468.159474574169 }, { - "id": "ef414", "x": 1056.277665995974, "y": 1520.5372331893523 } @@ -5341,7 +5278,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "f712d", - "isPartOf": "e1eb3", + "isPartOf": "c0f4f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5550,7 +5487,7 @@ "gpmlElementName": "DataNode", "height": 20.000000000000057, "id": "f9cd2", - "isPartOf": "c2bb1", + "isPartOf": "ec60e", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5646,9 +5583,6 @@ { "content": "Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contraction" }, - { - "content": "Type your comment here" - }, { "content": "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000084774", "source": "HomologyConvert" @@ -5694,6 +5628,36 @@ "y": 1191.61475, "zIndex": 32808 }, + "fb7e4": { + "contains": [ + "b3e23", + "d7585", + "c8e52" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 76.00000000000045, + "id": "fb7e4", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 96.00000000000091, + "x": 1327.7396162601976, + "y": 701.5420526105806, + "zIndex": 32865 + }, "fb9d6": { "comments": [ { @@ -5710,7 +5674,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "fb9d6", - 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"markerEnd": "MimConversion", + "markerEnd": "MimCleavage", "points": [ { "attachmentDisplay": { @@ -10179,7 +10029,6 @@ 1 ] }, - "id": "fec15", "isAttachedTo": "ecdc6", "orientation": [ 0, @@ -10189,7 +10038,6 @@ "y": 655.6560414912341 }, { - "id": "f5724", "x": 661.4089571866612, "y": 689.1920437499999 }, @@ -10204,7 +10052,6 @@ 1 ] }, - "id": "fb37d", "isAttachedTo": "ea673", "orientation": [ 0, @@ -10244,7 +10091,6 @@ 1 ] }, - "id": "b3659", "isAttachedTo": "aecb5", "orientation": [ 0, @@ -10265,7 +10111,6 @@ 0 ] }, - "id": "d6171", "isAttachedTo": "e8f99", "orientation": [ -1, @@ -10309,7 +10154,6 @@ 0.5 ] }, - "id": "adca0", "isAttachedTo": "d6348", "orientation": [ 1, @@ -10329,7 +10173,6 @@ 0 ] }, - "id": "d1f85", "isAttachedTo": "c798b", "orientation": [ 0, @@ -10370,7 +10213,6 @@ 0 ] }, - "id": "f134c", "isAttachedTo": "a80d3", "orientation": [ 0, @@ -10390,7 +10232,6 @@ 1 ] }, - "id": "ec7bf", "isAttachedTo": "f5531", "orientation": [ 0, @@ -10431,7 +10272,6 @@ 0 ] }, - "id": "cbbaa", "isAttachedTo": "fcf85", "orientation": [ 0, @@ -10451,7 +10291,6 @@ 1 ] }, - "id": "efe22", "isAttachedTo": "fcf85", "orientation": [ 0, @@ -10492,7 +10331,6 @@ 0.5 ] }, - "id": "cc8dc", "isAttachedTo": "eb0f9", "orientation": [ -1, @@ -10512,7 +10350,6 @@ 0.5 ] }, - "id": "fe804", "isAttachedTo": "dede3", "orientation": [ -1, @@ -10553,7 +10390,6 @@ 0.5 ] }, - "id": "eaed4", "isAttachedTo": "b0612", "orientation": [ 1, @@ -10573,7 +10409,6 @@ 0 ] }, - "id": "aed37", "isAttachedTo": "c2438", "orientation": [ 0, @@ -10618,7 +10453,6 @@ 0 ] }, - "id": "f3d1d", "isAttachedTo": "c59a7", "orientation": [ 0, @@ -10638,7 +10472,6 @@ 1 ] }, - "id": "a09f4", "isAttachedTo": "b8b30", "orientation": [ 0, @@ -10683,7 +10516,6 @@ 0.5 ] }, - "id": "e3eb5", "isAttachedTo": "c1b78", "orientation": [ 1, @@ -10704,7 +10536,6 @@ 0 ] }, - "id": "be76c", "isAttachedTo": "c92b8", "orientation": [], "x": 595.8156598528271, @@ -10742,7 +10573,6 @@ 1 ] }, - "id": "e8c15", "isAttachedTo": "add66", "orientation": [ 0, @@ -10762,7 +10592,6 @@ 0 ] }, - "id": "aa5a9", "isAttachedTo": "d3117", "orientation": [ 0, @@ -10787,7 +10616,7 @@ "id": "ide4b5bd77", "isAttachedTo": [ "cb8aa", - "c2bb1" + "ec60e" ], "kaavioType": "Edge", "markerStart": "MimInhibition", @@ -10803,7 +10632,6 @@ 0.5 ] }, - "id": "d76b4", "isAttachedTo": "cb8aa", "orientation": [ -1, @@ -10813,7 +10641,6 @@ "y": 868.6804245497667 }, { - "id": "ec618", "x": 1202.1334355338379, "y": 1002.9574677699704 }, @@ -10828,8 +10655,7 @@ 0.25 ] }, - "id": "add13", - "isAttachedTo": "c2bb1", + "isAttachedTo": "ec60e", "orientation": [ 1, 0 @@ -10869,7 +10695,6 @@ 0 ] }, - "id": "d9a00", "isAttachedTo": "e5627", "orientation": [ 0, @@ -10879,7 +10704,6 @@ "y": 505.75447356309996 }, { - "id": "dfbf1", "x": 718.7962625090095, "y": 463.29020718749996 }, @@ -10894,7 +10718,6 @@ 0 ] }, - "id": "a4fdb", "isAttachedTo": "af7ab", "orientation": [ 0, @@ -10936,7 +10759,6 @@ 0 ] }, - "id": "f2083", "isAttachedTo": "fae93", "orientation": [], "x": 1096.4977164574732, @@ -10953,7 +10775,6 @@ 0.25 ] }, - "id": "e998c", "isAttachedTo": "eb8b9", "orientation": [ 1, @@ -10994,7 +10815,6 @@ 0 ] }, - "id": "d7a03", "isAttachedTo": "a07bf", "orientation": [ 0, @@ -11014,7 +10834,6 @@ 1 ] }, - "id": "dbe43", "isAttachedTo": "cb8aa", "orientation": [ 0, @@ -11055,7 +10874,6 @@ 1 ] }, - "id": "af595", "isAttachedTo": "a7e1c", "orientation": [ 0, @@ -11075,7 +10893,6 @@ 0.5 ] }, - "id": "b8d83", "isAttachedTo": "b5d52", "orientation": [ -1, @@ -11099,7 +10916,7 @@ "gpmlElementName": "Interaction", "id": "idec4acaef", "isAttachedTo": [ - "ee21f", + "fb7e4", "cb8aa" ], "kaavioType": "Edge", @@ -11116,8 +10933,7 @@ 1 ] }, - "id": "b4962", - "isAttachedTo": "ee21f", + "isAttachedTo": "fb7e4", "orientation": [ 0, 1 @@ -11136,7 +10952,6 @@ 0 ] }, - "id": "a9dff", "isAttachedTo": "cb8aa", "orientation": [ 0, @@ -11177,7 +10992,6 @@ 1 ] }, - "id": "d0abd", "isAttachedTo": "ea673", "orientation": [ 0, @@ -11197,7 +11011,6 @@ 0 ] }, - "id": "ecfb8", "isAttachedTo": "f91ef", "orientation": [ 0, @@ -11238,7 +11051,6 @@ 1 ] }, - "id": "ff98c", "isAttachedTo": "ecbbe", "orientation": [ 0, @@ -11258,7 +11070,6 @@ 0 ] }, - "id": "e0f29", "isAttachedTo": "b19b8", "orientation": [ 0, @@ -11299,7 +11110,6 @@ 1 ] }, - "id": "cd70b", "isAttachedTo": "cfff8", "orientation": [ 0, @@ -11319,7 +11129,6 @@ 0 ] }, - "id": "a1a67", "isAttachedTo": "b2b06", "orientation": [ 0, @@ -11360,7 +11169,6 @@ 1 ] }, - "id": "e49a8", "isAttachedTo": "dbfe0", "orientation": [ 0, @@ -11380,7 +11188,6 @@ 0 ] }, - "id": "c0035", "isAttachedTo": "d3783", "orientation": [ 0, @@ -11428,7 +11235,6 @@ 1 ] }, - "id": "f08ef", "isAttachedTo": "e2944", "orientation": [ 0, @@ -11448,7 +11254,6 @@ 0 ] }, - "id": "c285d", "isAttachedTo": "e58f6", "orientation": [ 0, @@ -11489,7 +11294,6 @@ 0.5 ] }, - "id": "e5522", "isAttachedTo": "cb8aa", "orientation": [ 1, @@ -11510,7 +11314,6 @@ 0 ] }, - "id": "b5cc5", "isAttachedTo": "cfb78", "orientation": [], "x": 1524.5921250000008, @@ -11548,7 +11351,6 @@ 0.5 ] }, - "id": "d115f", "isAttachedTo": "e6db6", "orientation": [ 1, @@ -11568,7 +11370,6 @@ 1 ] }, - "id": "c95b1", "isAttachedTo": "a766a", "orientation": [ 0, @@ -11609,7 +11410,6 @@ 0 ] }, - "id": "a8000", "isAttachedTo": "c3a56", "orientation": [ 0, @@ -11629,7 +11429,6 @@ 1 ] }, - "id": "f809f", "isAttachedTo": "e7508", "orientation": [ 0, @@ -11670,7 +11469,6 @@ 0.5 ] }, - "id": "d2158", "isAttachedTo": "b65a0", "orientation": [ -1, @@ -11690,7 +11488,6 @@ 1 ] }, - "id": "a6e12", "isAttachedTo": "aecb5", "orientation": [ 0, @@ -11717,10 +11514,10 @@ "@context": [ "https://cdn.rawgit.com/wikipathways/WpVocabularies/7a46a05/contexts/pvjs.jsonld", { - "@base": "http://identifiers.org/wikipathways/WP3246/" + "@base": "WP3246/" } ], - "author": "[Mkutmon, MaintBot, Eweitz]", + "author": "[Mkutmon, MaintBot, Eweitz, Egonw]", "comments": [ { "content": "Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation.", @@ -11864,7 +11661,7 @@ "add66", "c3a11", "f91ef", - "b14fe", + "a856b", "a5e7a", "f2e4b", "b095d", @@ -11893,7 +11690,7 @@ "d72ea", "e3e88", "f0bd1", - "d0edd", + "bffb7", "e5627", "af7ab", "d0796", @@ -11913,13 +11710,13 @@ "a766a", "eb0f9", "b2b06", - "ee21f", + "fb7e4", "fcf85", "idd6df9893", "ida34203ec", - "e1eb3", + "c0f4f", "d707a", - "a9e08", + "c2b49", "f22ba", "d16ab", "e2338", @@ -11931,20 +11728,20 @@ "dd011", "f206f", "a80d3", - "e7d54", + "c18cd", "e7324", "db6fe", "b4371", "ba19a", "b5d52", - "c2bb1", + "ec60e", "ecbbe", "d3783", "c3a56", "bcb2e", "ffa5e" ], - "dataSourceVersion": "WP3246_r117509", + "dataSourceVersion": "WP3246_r134267", "displayName": "Endothelin pathways", "drawAs": "rect", "fill": "white", @@ -11952,9 +11749,9 @@ "fontWeight": "bold", "gpmlElementName": "Pathway", "height": 1777.2818239677451, - "id": "http://identifiers.org/wikipathways/WP3246", + "id": "WP3246", "kaavioType": "Group", - "lastModified": "20210521110545", + "lastModified": "20240719064228", "name": "Endothelin pathways", "organism": "Bos taurus", "padding": 5, @@ -11963,15 +11760,15 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Endothelin pathways\nLast Modified: 20210521110545\nOrganism: Bos taurus", + "textContent": "Name: Endothelin pathways\nLast Modified: 20240719064228\nOrganism: Bos taurus", "type": [ "Pathway", - "http://identifiers.org/pw/PW:0000314", "http://identifiers.org/pw/PW:0000228", + "http://identifiers.org/pw/PW:0000314", "http://identifiers.org/pw/PW:0000227", + "http://identifiers.org/pw/PW:0000506", "http://identifiers.org/pw/PW:0000006", - "http://identifiers.org/pw/PW:0000229", - "http://identifiers.org/pw/PW:0000506" + "http://identifiers.org/pw/PW:0000229" ], "verticalAlign": "top", "width": 1789.9841124263874, diff --git a/pathways/WP3246/WP3246.png b/pathways/WP3246/WP3246.png index e99b1a919..4fe5f1fb4 100644 Binary files a/pathways/WP3246/WP3246.png and b/pathways/WP3246/WP3246.png differ diff --git a/pathways/WP3246/WP3246.svg b/pathways/WP3246/WP3246.svg index d94a06e60..d53961a2a 100644 --- a/pathways/WP3246/WP3246.svg +++ b/pathways/WP3246/WP3246.svg @@ -1,5 +1,5 @@ - + @@ -484,8 +484,8 @@ - - + + @@ -533,8 +533,8 @@ - - + + @@ -573,8 +573,8 @@ - - + + @@ -639,8 +639,8 @@ - - + + @@ -655,8 +655,8 @@ - - + + @@ -803,8 +803,8 @@ - - + + @@ -841,8 +841,8 @@ - - + + @@ -866,8 +866,8 @@ - - + + @@ -904,8 +904,8 @@ - - + + @@ -1202,8 +1202,8 @@ PRKCA - - + + @@ -1216,7 +1216,7 @@ GNB5 - + GNG13 @@ -1295,7 +1295,7 @@ IP3R - + Pre-pro ET1 @@ -1382,8 +1382,8 @@ EDNRB - - + + @@ -1396,7 +1396,7 @@ GNB5 - + GNG13 @@ -1511,8 +1511,8 @@ K+ - - + + @@ -1525,7 +1525,7 @@ GNB5 - + GNG13 @@ -1545,8 +1545,8 @@ - - + + @@ -1559,7 +1559,7 @@ GNB5 - + GNG13 @@ -1572,8 +1572,8 @@ ADRB1 - - + + @@ -1586,7 +1586,7 @@ GNB5 - + GNG13 @@ -1657,8 +1657,8 @@ CT - - + + @@ -1671,7 +1671,7 @@ GNB5 - + GNG13 @@ -1705,8 +1705,8 @@ NPY - - + + @@ -1719,7 +1719,7 @@ GNB5 - + GNG13 @@ -1755,9 +1755,9 @@ Cellular growth and survival - + Name: Endothelin pathways - Last Modified: 20210521110545 + Last Modified: 20240719064228 Organism: Bos taurus diff --git a/pathways/WP3271/WP3271-bibliography.tsv b/pathways/WP3271/WP3271-bibliography.tsv index 5633bbf0d..9f989c248 100644 --- a/pathways/WP3271/WP3271-bibliography.tsv +++ b/pathways/WP3271/WP3271-bibliography.tsv @@ -1,2 +1,2 @@ ID Database Citation -20067622 Pubmed "Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. NetPath: a public resource of curated signal transduction pathways. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia" +20067622 Pubmed "NetPath: a public resource of curated signal transduction pathways. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia" diff --git a/pathways/WP3271/WP3271-datanodes.tsv b/pathways/WP3271/WP3271-datanodes.tsv index 395fdd5d9..d8bf25b55 100644 --- a/pathways/WP3271/WP3271-datanodes.tsv +++ b/pathways/WP3271/WP3271-datanodes.tsv @@ -1,68 +1,53 @@ -Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI -Ca 2+ Metabolite hmdb:HMDB0000464 chebi:29108;chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N -UBE2N Protein ensembl:ENSBTAG00000021767 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7334 ensembl:ENSBTAG00000021767 ncbigene:541130 uniprot:A0A3Q1N9B4;uniprot:A0A3Q1MW26;uniprot:Q0P5K3 -MAP3K2 Protein ensembl:ENSBTAG00000004216 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10746 ensembl:ENSBTAG00000004216 ncbigene:504592 uniprot:F1MSX4 -REL Protein ensembl:ENSBTAG00000015386 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5966 ensembl:ENSBTAG00000015386 ncbigene:509135 uniprot:F1MJH6 -MAPK3 Protein ensembl:ENSBTAG00000016156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595 ensembl:ENSBTAG00000016156 ncbigene:531391 uniprot:E1B8P9;uniprot:A0A3Q1M7B5;uniprot:A0A3Q1MNN7 -IKBKB Protein ensembl:ENSBTAG00000007599 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3551 ensembl:ENSBTAG00000007599 ncbigene:281854 uniprot:Q95KV0;uniprot:A0A3Q1NNA5 -PRKCZ Protein ensembl:ENSBTAG00000014119 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590 ensembl:ENSBTAG00000014119 ncbigene:286877 uniprot:A0A3Q1MI80;uniprot:A0JNH7;uniprot:A0A3Q1MSP9 -TAB2 Protein ensembl:ENSBTAG00000013454 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23118 ensembl:ENSBTAG00000013454 ncbigene:540203 uniprot:E1B7Z0 -MAP3K14 Protein ensembl:ENSBTAG00000007084 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000006062 ensembl:ENSBTAG00000007084 ncbigene:508367 uniprot:E1BL08 -MAP2K2 Protein ensembl:ENSBTAG00000024450 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605 ensembl:ENSBTAG00000024450 ncbigene:510434 uniprot:Q17QH2;uniprot:A0A3S5ZPX3 -TRAF6 Protein ensembl:ENSBTAG00000036009 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7189 ensembl:ENSBTAG00000036009 ncbigene:539124 uniprot:Q3ZCC3 -MYD88 Protein ensembl:ENSBTAG00000000563 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4615 ensembl:ENSBTAG00000000563 ncbigene:444881 uniprot:E1BPY7;uniprot:A0A452DHW6 -TOLLIP Protein ensembl:ENSBTAG00000008237 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54472 ensembl:ENSBTAG00000008237 ncbigene:539480 uniprot:Q2LGB5 -TOLLIP Protein ensembl:ENSBTAG00000008237 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54472 ensembl:ENSBTAG00000008237 ncbigene:539480 uniprot:Q2LGB5 -ECSIT Protein ensembl:ENSBTAG00000015049 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51295 ensembl:ENSBTAG00000015049 ncbigene:507245 uniprot:Q3SX05 -SQSTM1 Protein ensembl:ENSBTAG00000015591 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8878 ensembl:ENSBTAG00000015591 ncbigene:338045 uniprot:A0A3Q1LVE4;uniprot:F1MIE2 -CHUK Protein ensembl:ENSBTAG00000007591 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1147 ensembl:ENSBTAG00000007591 ncbigene:281073 uniprot:A0A3Q1MBB2;uniprot:Q95KV1 -NFKBIB Protein ensembl:ENSBTAG00000001778 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4793 ensembl:ENSBTAG00000001778 ncbigene:525408 uniprot:Q0IIB2 -RELA Protein ensembl:ENSBTAG00000013895 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970 ensembl:ENSBTAG00000013895 ncbigene:508233 uniprot:A1XG22;uniprot:A0A3Q1LNY5 -MAPK14 Protein ensembl:ENSBTAG00000020783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432 ensembl:ENSBTAG00000020783 ncbigene:534492 uniprot:F6PU21;uniprot:A0A3Q1LTT9;uniprot:A0A3Q1M517;uniprot:A0A3Q1M8H8 -BIKBA Protein ensembl:ENSBTAG00000016683 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4792 ensembl:ENSBTAG00000016683 ncbigene:282291 uniprot:Q8WNW7 -NFKB1 Protein ensembl:ENSBTAG00000020270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790 ensembl:ENSBTAG00000020270 ncbigene:616115 uniprot:F1MKW9;uniprot:A0A3Q1LGS4 -AKT1 Protein ensembl:ENSBTAG00000017636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207 ensembl:ENSBTAG00000017636 ncbigene:280991 uniprot:A0A3Q1MJ77;uniprot:G3X7B5 -NFKB1 Protein ensembl:ENSBTAG00000020270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790 ensembl:ENSBTAG00000020270 ncbigene:616115 uniprot:F1MKW9;uniprot:A0A3Q1LGS4 -TRAF6 Protein ensembl:ENSBTAG00000036009 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7189 ensembl:ENSBTAG00000036009 ncbigene:539124 uniprot:Q3ZCC3 -PIK3R1 Protein ensembl:ENSBTAG00000010989 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295 ensembl:ENSBTAG00000010989 ncbigene:282307 uniprot:P23727;uniprot:A0A3Q1LW04;uniprot:A0A3Q1M401 -MAP2K3 Protein ensembl:ENSBTAG00000010576 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606 ensembl:ENSBTAG00000010576 ncbigene:516039 uniprot:A0A3Q1N5Y6;uniprot:A0A3Q1LL86;uniprot:F6S1D0;uniprot:A0A3Q1MNG1 -TRAF6 Protein ensembl:ENSBTAG00000036009 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7189 ensembl:ENSBTAG00000036009 ncbigene:539124 uniprot:Q3ZCC3 -PELI1 Protein ensembl:ENSBTAG00000020865 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57162 ensembl:ENSBTAG00000020865 ncbigene:535054 uniprot:A0A3Q1M9E2;uniprot:A0JN70 -IKBKG Protein ensembl:ENSBTAG00000006268 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517 ensembl:ENSBTAG00000006268 ncbigene:281855 uniprot:Q95KU9 -MYD88 Protein ensembl:ENSBTAG00000000563 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4615 ensembl:ENSBTAG00000000563 ncbigene:444881 uniprot:E1BPY7;uniprot:A0A452DHW6 -PTPN11 Protein ensembl:ENSBTAG00000002048 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781 ensembl:ENSBTAG00000002048 ncbigene:533590 uniprot:F1N339 -MAPKAPK2 Protein ensembl:ENSBTAG00000038107 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9261 ensembl:ENSBTAG00000038107 ncbigene:788091 uniprot:A0A3Q1MET0;uniprot:F1MCX5;uniprot:A0A3Q1M2S5;uniprot:A0A3Q1M614;uniprot:A0A3Q1M8E4 -MAPK1 Protein ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594 ensembl:ENSBTAG00000010312 ncbigene:327672 uniprot:P46196 -RELA Protein ensembl:ENSBTAG00000013895 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970 ensembl:ENSBTAG00000013895 ncbigene:508233 uniprot:A1XG22;uniprot:A0A3Q1LNY5 -MAP2K1 Protein ensembl:ENSBTAG00000033983 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604 ensembl:ENSBTAG00000033983 ncbigene:533199 uniprot:Q0VD16 -PLCG1 Protein ensembl:ENSBTAG00000017584 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5335 ensembl:ENSBTAG00000017584 ncbigene:281987 uniprot:F1MYF9 -TRAF6 Protein ensembl:ENSBTAG00000036009 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7189 ensembl:ENSBTAG00000036009 ncbigene:539124 uniprot:Q3ZCC3 -IL1A Protein ensembl:ENSBTAG00000010349 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3552 ensembl:ENSBTAG00000010349 ncbigene:281250 uniprot:A0A3Q1LXP9;uniprot:P08831 -TAB3 Protein ensembl:ENSBTAG00000048159 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:257397 ensembl:ENSBTAG00000048159 ncbigene:788288 uniprot:A0A3Q1M6M0;uniprot:G3N227;uniprot:A0A3Q1M7T8;uniprot:A0A3Q1M2M0 -MAP2K6 Protein ensembl:ENSBTAG00000001609 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608 ensembl:ENSBTAG00000001609 ncbigene:286883 uniprot:Q5E9X2;uniprot:A0A3Q1M703;uniprot:A0A3Q1LLK9 -IL1RAP Protein ensembl:ENSBTAG00000013205 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3556 ensembl:ENSBTAG00000013205 ncbigene:539334 uniprot:A0A3Q1LQK2;uniprot:A0A3Q1MKU4;uniprot:F6PSK5;uniprot:E1BFL8 -IL1B Protein ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553 ensembl:ENSBTAG00000001321 ncbigene:281251 uniprot:A0A140T838 -REL Protein ensembl:ENSBTAG00000015386 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5966 ensembl:ENSBTAG00000015386 ncbigene:509135 uniprot:F1MJH6 -MAPK8 Protein ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599 ensembl:ENSBTAG00000007876 ncbigene:539941 uniprot:A0A3Q1MG18;uniprot:F1MM73;uniprot:A0A3Q1NK45;uniprot:A0A3Q1LWJ8 -IL1R1 Protein ensembl:ENSBTAG00000005273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3554 ensembl:ENSBTAG00000005273 ncbigene:515640 uniprot:F1ML75 -MAPK9 Protein ensembl:ENSBTAG00000004709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601 ensembl:ENSBTAG00000004709 ncbigene:534125 uniprot:A0A3Q1LJU7;uniprot:A0A3Q1LVH0;uniprot:Q2KI72 -IL1RAP Protein ensembl:ENSBTAG00000013205 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3556 ensembl:ENSBTAG00000013205 ncbigene:539334 uniprot:A0A3Q1LQK2;uniprot:A0A3Q1MKU4;uniprot:F6PSK5;uniprot:E1BFL8 -PELI2 Protein ensembl:ENSBTAG00000005141 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57161 ensembl:ENSBTAG00000005141 ncbigene:100337503 uniprot:F1MNJ6;uniprot:A0A3Q1LQ14;uniprot:A0A3Q1NLG1 -MAP3K1 Protein ensembl:ENSBTAG00000013790 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214 ensembl:ENSBTAG00000013790 ncbigene:523962 uniprot:E1B847 -MAP2K7 Protein ensembl:ENSBTAG00000010639 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5609 ensembl:ENSBTAG00000010639 ncbigene:787278 uniprot:A0A3Q1LMF7;uniprot:F1N664 -MAP3K3 Protein ensembl:ENSBTAG00000008151 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4215 ensembl:ENSBTAG00000008151 ncbigene:508943 uniprot:A0A3Q1LPF2;uniprot:F1MH06 -MAP3K7IP1 Protein ensembl:ENSBTAG00000019828 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10454 ensembl:ENSBTAG00000019828 ncbigene:519958 uniprot:A0A3Q1LT51;uniprot:F6QID7 -MAP2K4 Protein ensembl:ENSBTAG00000012103 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6416 ensembl:ENSBTAG00000012103 ncbigene:526469 uniprot:A0A3Q1N7I1;uniprot:A5PJP8;uniprot:A0A3Q1LTC6 -TRAF6 Protein ensembl:ENSBTAG00000036009 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7189 ensembl:ENSBTAG00000036009 ncbigene:539124 uniprot:Q3ZCC3 -IKBKG Protein ensembl:ENSBTAG00000006268 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517 ensembl:ENSBTAG00000006268 ncbigene:281855 uniprot:Q95KU9 -IL1R1 Protein ensembl:ENSBTAG00000005273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3554 ensembl:ENSBTAG00000005273 ncbigene:515640 uniprot:F1ML75 -IRAK4 Protein ensembl:ENSBTAG00000021105 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51135 ensembl:ENSBTAG00000021105 ncbigene:533692 uniprot:Q1RMT8 -IRAK1 Protein ensembl:ENSBTAG00000016085 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3654 ensembl:ENSBTAG00000016085 ncbigene:533953 uniprot:Q2LGB3;uniprot:D3WYX4 -IRAKM Protein ensembl:ENSBTAG00000007636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11213 ensembl:ENSBTAG00000007636 ncbigene:510342 uniprot:A0A3Q1LLP4;uniprot:A0A3Q1LZ92;uniprot:A0A3Q1N803;uniprot:B3FXL5;uniprot:B3FXL3 -IRAK2 Protein ensembl:ENSBTAG00000006193 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3656 ensembl:ENSBTAG00000006193 ncbigene:515034 uniprot:A0A3Q1LWV2;uniprot:A0A3Q1M5T8;uniprot:Q0P5I2;uniprot:G3MWW5 -MAP3K7 Protein ensembl:ENSBTAG00000002625 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885 ensembl:ENSBTAG00000002625 ncbigene:529146 uniprot:A0A3Q1NDP1;uniprot:A0A3Q1LPM7;uniprot:A2VDU3 -MAPK14 Protein ensembl:ENSBTAG00000020783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432 ensembl:ENSBTAG00000020783 ncbigene:534492 uniprot:F6PU21;uniprot:A0A3Q1LTT9;uniprot:A0A3Q1M517;uniprot:A0A3Q1M8H8 -JUN Protein ensembl:ENSBTAG00000004037 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725 ensembl:ENSBTAG00000004037 ncbigene:280831 uniprot:Q08DH1 -ATF2 Protein ensembl:ENSBTAG00000002295 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1386 ensembl:ENSBTAG00000002295 ncbigene:509827 uniprot:F1N177;uniprot:A2VDL1 -MAPK9 Protein ensembl:ENSBTAG00000004709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601 ensembl:ENSBTAG00000004709 ncbigene:534125 uniprot:A0A3Q1LJU7;uniprot:A0A3Q1LVH0;uniprot:Q2KI72 -MAPK8 Protein ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599 ensembl:ENSBTAG00000007876 ncbigene:539941 uniprot:A0A3Q1MG18;uniprot:F1MM73;uniprot:A0A3Q1NK45;uniprot:A0A3Q1LWJ8 +Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps +Ca 2+ Metabolite hmdb:HMDB0000464 "" chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N pubchem.compound:271 chemspider:266 hmdb:HMDB0000464 kegg.compound:C00076 +UBE2N Protein ensembl:ENSBTAG00000021767 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7334" ensembl:ENSBTAG00000021767 ncbigene:541130 uniprot:A0A3Q1N9B4;uniprot:A0A3Q1MW26;uniprot:Q0P5K3 +MAP3K2 Protein ensembl:ENSBTAG00000004216 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10746" ensembl:ENSBTAG00000004216 ncbigene:504592 uniprot:F1MSX4 +REL Protein ensembl:ENSBTAG00000015386 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5966" ensembl:ENSBTAG00000015386 ncbigene:509135 uniprot:F1MJH6 +MAPK3 Protein ensembl:ENSBTAG00000016156 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595" ensembl:ENSBTAG00000016156 ncbigene:531391 uniprot:E1B8P9;uniprot:A0A3Q1M7B5;uniprot:A0A3Q1MNN7 +IKBKB Protein ensembl:ENSBTAG00000007599 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3551" ensembl:ENSBTAG00000007599 ncbigene:281854 uniprot:Q95KV0;uniprot:A0A3Q1NNA5 +PRKCZ Protein ensembl:ENSBTAG00000014119 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590" ensembl:ENSBTAG00000014119 ncbigene:286877 uniprot:A0A3Q1MI80;uniprot:A0JNH7;uniprot:A0A3Q1MSP9 +TAB2 Protein ensembl:ENSBTAG00000013454 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23118" ensembl:ENSBTAG00000013454 ncbigene:540203 uniprot:E1B7Z0 +MAP3K14 Protein ensembl:ENSBTAG00000007084 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000006062" ensembl:ENSBTAG00000007084 ncbigene:508367 uniprot:E1BL08 +MAP2K2 Protein ensembl:ENSBTAG00000024450 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605" ensembl:ENSBTAG00000024450 ncbigene:510434 uniprot:Q17QH2;uniprot:A0A3S5ZPX3 +TRAF6 Protein ensembl:ENSBTAG00000036009 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7189" ensembl:ENSBTAG00000036009 ncbigene:539124 uniprot:Q3ZCC3 +MYD88 Protein ensembl:ENSBTAG00000000563 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4615" ensembl:ENSBTAG00000000563 ncbigene:444881 uniprot:E1BPY7;uniprot:A0A452DHW6 +TOLLIP Protein ensembl:ENSBTAG00000008237 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54472" ensembl:ENSBTAG00000008237 ncbigene:539480 uniprot:Q2LGB5 +ECSIT Protein ensembl:ENSBTAG00000015049 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51295" ensembl:ENSBTAG00000015049 ncbigene:507245 uniprot:Q3SX05 +SQSTM1 Protein ensembl:ENSBTAG00000015591 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8878" ensembl:ENSBTAG00000015591 ncbigene:338045 uniprot:A0A3Q1LVE4;uniprot:F1MIE2 +CHUK Protein ensembl:ENSBTAG00000007591 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1147" ensembl:ENSBTAG00000007591 ncbigene:281073 uniprot:A0A3Q1MBB2;uniprot:Q95KV1 +NFKBIB Protein ensembl:ENSBTAG00000001778 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4793" ensembl:ENSBTAG00000001778 ncbigene:525408 uniprot:Q0IIB2 +RELA Protein ensembl:ENSBTAG00000013895 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970" ensembl:ENSBTAG00000013895 ncbigene:508233 uniprot:A1XG22;uniprot:A0A3Q1LNY5 +MAPK14 Protein ensembl:ENSBTAG00000020783 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432" ensembl:ENSBTAG00000020783 ncbigene:534492 uniprot:F6PU21;uniprot:A0A3Q1LTT9;uniprot:A0A3Q1M517;uniprot:A0A3Q1M8H8 +BIKBA Protein ensembl:ENSBTAG00000016683 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4792" ensembl:ENSBTAG00000016683 ncbigene:282291 uniprot:Q8WNW7 +NFKB1 Protein ensembl:ENSBTAG00000020270 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790" ensembl:ENSBTAG00000020270 ncbigene:616115 uniprot:F1MKW9;uniprot:A0A3Q1LGS4 +AKT1 Protein ensembl:ENSBTAG00000017636 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207" ensembl:ENSBTAG00000017636 ncbigene:280991 uniprot:A0A3Q1MJ77;uniprot:G3X7B5 +PIK3R1 Protein ensembl:ENSBTAG00000010989 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295" ensembl:ENSBTAG00000010989 ncbigene:282307 uniprot:P23727;uniprot:A0A3Q1LW04;uniprot:A0A3Q1M401 +MAP2K3 Protein ensembl:ENSBTAG00000010576 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606" ensembl:ENSBTAG00000010576 ncbigene:516039 uniprot:A0A3Q1N5Y6;uniprot:A0A3Q1LL86;uniprot:F6S1D0;uniprot:A0A3Q1MNG1 +PELI1 Protein ensembl:ENSBTAG00000020865 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57162" ensembl:ENSBTAG00000020865 ncbigene:535054 uniprot:A0A3Q1M9E2;uniprot:A0JN70 +IKBKG Protein ensembl:ENSBTAG00000006268 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517" ensembl:ENSBTAG00000006268 ncbigene:281855 uniprot:Q95KU9 +PTPN11 Protein ensembl:ENSBTAG00000002048 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781" ensembl:ENSBTAG00000002048 ncbigene:533590 uniprot:F1N339 +MAPKAPK2 Protein ensembl:ENSBTAG00000038107 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9261" ensembl:ENSBTAG00000038107 ncbigene:788091 uniprot:A0A3Q1MET0;uniprot:F1MCX5;uniprot:A0A3Q1M2S5;uniprot:A0A3Q1M614;uniprot:A0A3Q1M8E4 +MAPK1 Protein ensembl:ENSBTAG00000010312 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594" ensembl:ENSBTAG00000010312 ncbigene:327672 uniprot:P46196 +MAP2K1 Protein ensembl:ENSBTAG00000033983 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604" ensembl:ENSBTAG00000033983 ncbigene:533199 uniprot:Q0VD16 +PLCG1 Protein ensembl:ENSBTAG00000017584 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5335" ensembl:ENSBTAG00000017584 ncbigene:281987 uniprot:F1MYF9 +IL1A Protein ensembl:ENSBTAG00000010349 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3552" ensembl:ENSBTAG00000010349 ncbigene:281250 uniprot:A0A3Q1LXP9;uniprot:P08831 +TAB3 Protein ensembl:ENSBTAG00000048159 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:257397" ensembl:ENSBTAG00000048159 ncbigene:788288 uniprot:A0A3Q1M6M0;uniprot:G3N227;uniprot:A0A3Q1M7T8;uniprot:A0A3Q1M2M0 +MAP2K6 Protein ensembl:ENSBTAG00000001609 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608" ensembl:ENSBTAG00000001609 ncbigene:286883 uniprot:Q5E9X2;uniprot:A0A3Q1M703;uniprot:A0A3Q1LLK9 +IL1RAP Protein ensembl:ENSBTAG00000013205 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3556" ensembl:ENSBTAG00000013205 ncbigene:539334 uniprot:A0A3Q1LQK2;uniprot:A0A3Q1MKU4;uniprot:F6PSK5;uniprot:E1BFL8 +IL1B Protein ensembl:ENSBTAG00000001321 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553" ensembl:ENSBTAG00000001321 ncbigene:281251 uniprot:A0A140T838 +MAPK8 Protein ensembl:ENSBTAG00000007876 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599" ensembl:ENSBTAG00000007876 ncbigene:539941 uniprot:A0A3Q1MG18;uniprot:F1MM73;uniprot:A0A3Q1NK45;uniprot:A0A3Q1LWJ8 +IL1R1 Protein ensembl:ENSBTAG00000005273 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3554" ensembl:ENSBTAG00000005273 ncbigene:515640 uniprot:F1ML75 +MAPK9 Protein ensembl:ENSBTAG00000004709 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601" ensembl:ENSBTAG00000004709 ncbigene:534125 uniprot:A0A3Q1LJU7;uniprot:A0A3Q1LVH0;uniprot:Q2KI72 +PELI2 Protein ensembl:ENSBTAG00000005141 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57161" ensembl:ENSBTAG00000005141 ncbigene:100337503 uniprot:F1MNJ6;uniprot:A0A3Q1LQ14;uniprot:A0A3Q1NLG1 +MAP3K1 Protein ensembl:ENSBTAG00000013790 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214" ensembl:ENSBTAG00000013790 ncbigene:523962 uniprot:E1B847 +MAP2K7 Protein ensembl:ENSBTAG00000010639 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5609" ensembl:ENSBTAG00000010639 ncbigene:787278 uniprot:A0A3Q1LMF7;uniprot:F1N664 +MAP3K3 Protein ensembl:ENSBTAG00000008151 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4215" ensembl:ENSBTAG00000008151 ncbigene:508943 uniprot:A0A3Q1LPF2;uniprot:F1MH06 +MAP3K7IP1 Protein ensembl:ENSBTAG00000019828 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10454" ensembl:ENSBTAG00000019828 ncbigene:519958 uniprot:A0A3Q1LT51;uniprot:F6QID7 +MAP2K4 Protein ensembl:ENSBTAG00000012103 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6416" ensembl:ENSBTAG00000012103 ncbigene:526469 uniprot:A0A3Q1N7I1;uniprot:A5PJP8;uniprot:A0A3Q1LTC6 +IRAK4 Protein ensembl:ENSBTAG00000021105 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51135" ensembl:ENSBTAG00000021105 ncbigene:533692 uniprot:Q1RMT8 +IRAK1 Protein ensembl:ENSBTAG00000016085 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3654" ensembl:ENSBTAG00000016085 ncbigene:533953 uniprot:Q2LGB3;uniprot:D3WYX4 +IRAKM Protein ensembl:ENSBTAG00000007636 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11213" ensembl:ENSBTAG00000007636 ncbigene:510342 uniprot:A0A3Q1LLP4;uniprot:A0A3Q1LZ92;uniprot:A0A3Q1N803;uniprot:B3FXL5;uniprot:B3FXL3 +IRAK2 Protein ensembl:ENSBTAG00000006193 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3656" ensembl:ENSBTAG00000006193 ncbigene:515034 uniprot:A0A3Q1LWV2;uniprot:A0A3Q1M5T8;uniprot:Q0P5I2;uniprot:G3MWW5 +MAP3K7 Protein ensembl:ENSBTAG00000002625 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885" ensembl:ENSBTAG00000002625 ncbigene:529146 uniprot:A0A3Q1NDP1;uniprot:A0A3Q1LPM7;uniprot:A2VDU3 +JUN Protein ensembl:ENSBTAG00000004037 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725" ensembl:ENSBTAG00000004037 ncbigene:280831 uniprot:Q08DH1 +ATF2 Protein ensembl:ENSBTAG00000002295 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1386" ensembl:ENSBTAG00000002295 ncbigene:509827 uniprot:F1N177;uniprot:A2VDL1 diff --git a/pathways/WP3271/WP3271.gpml b/pathways/WP3271/WP3271.gpml index e4e469406..6c4ca9088 100644 --- a/pathways/WP3271/WP3271.gpml +++ b/pathways/WP3271/WP3271.gpml @@ -1,5 +1,5 @@ - + The IL-1 family of cytokines currently consists of 11 members which are encoded by distinct genes and includes IL-1α, IL-1β, and the IL-1 Receptor antagonist (IL-1RA). The major role of IL-1 type cytokines is to control pro-inflammatory reactions in response to tissue injury - either due to pathogen-associated molecular patterns (PAMPs) or Danger associated molecular patterns (DAMPs). Interleukin-1 (IL-1), which includes IL-1α and IL-1β, plays a crucial role in many auto inflammatory diseases. IL- 1α and IL-1β are produced predominantly by macrophages and monocytes, and to a lesser extent by other cell types such as epithelial cells endothelial cells and fibroblasts. IL-1 alpha, is a membrane anchored protein which signals through autocrine or juxtracrine mechanisms where as the soluble IL-1β acts in a paracrine or systemic manner. Significant progress has been achieved in the study of the signaling events mediated by IL-1 and the processes they control. Involvement of IL-1α or IL-1β in host responses to infections caused by intracellular microorganisms such as Mycobacterium tuberculosis as well as in autoinflammatory diseases makes its signaling components important candidates for drug targetting for these diseases. The two forms of IL-1 (IL-1α and IL-1β) bind to the same cellular receptor, the Type I IL- 1 receptor (IL-1RI) to induce signaling. Upon receptor engagement, IL-1R1 forms a heterodimer with IL-1 receptor accessory protein (IL-1RAcP), which functions as a co receptor. IL-1RAcP cannot bind directly to IL-1 but is essential for IL-1-mediated signaling. Binding of IL-1 to this receptor complex leads to the activation of the transcription factor NF-κB through different signaling mechanisms. Two IL-1 receptor-associated kinases, IRAK-1 and IRAK-2 have been implicated in the activation of NF-κB. IRAK 1 and 2 functions as adapter proteins and protein kinases to transmit downstream signals. It recruits TRAF6 to the IL-1 receptor complex via an interaction with IL-1RAcP. Oligomerization of TRAF6 and subsequent formation of TAK1 and MEKK3 signaling complexes relays the signal via NF-κB-inducing kinase (NIK) to two I-kappaB kinases (IKK-1 and -2), leading to NF-kappaB activation. Activation of other mitogen activated protein kinases, including JNKs and p38 MAPK through various MAP2Ks also play important roles in mediating IL-1 responses by activating transcription through the AP-1 transcription factor. The above mentioned signaling events co-operatively induce the expression of IL-1 target genes such as CCL2, IL-8 and IL-6. The interactions and intersections between canonical and non-canonical Interleukin-1 signaling systems are depicted in the pathway map. Regulation of IL-1 signaling can be brought about by various mechanisms. The IL-1 family member IL-1RA can bind to the IL1-R1 receptor with similar affinity as IL-1α and β, but is incapable of activating the signaling response. The type II IL-1 receptor can bind to IL-1 alpha and beta but lacks signaling capacity. The naturally occurring 'shed' domains of the extracellular IL-1 receptor chains (IL-1RI, IL-1RII and IL- 1RAcP) also act as inhibitors of IL-1 signaling. In the cell, IL-1R binds to toll- interacting protein (TOLLIP), which results in the inhibition of IRAK1 and by promoting efficient degradation of IL-1R by targeting the internalized receptor to endosomes. Other mechanisms such as p38MAPK mediated phosphorylation of TAB1 which results in the inactivation of TAK1, and expression of genes including MAPK phosphatase 1 (MKP-1) and Inhibitor of kappa B alpha (NFKBIA) that inhibit IL-1 signaling components also serve as negative regulators of IL-1 signaling. Please access this pathway at [http://www.netpath.org/netslim/IL_1_pathway.html NetSlim] database. @@ -118,7 +118,7 @@ Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugo - + HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6347 @@ -363,38 +363,39 @@ Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugo - - Stimulation of the IL-1 receptor complex induces the phosphorylation dependent activation of MEKK2. - + + IL-1 stimulates the phosphorylation and activation of MAP2K4 + - - + + IL-1 beta stimulates the ubiquitination of TRAF6 in HeLa cells and in MEF cells. + - - IL-1 stimulates the phosphorylation of HSP27 in Hep G2 cells - + + IL-1 beta induces the phosphorylation of JNK1 in beta rat synovial fibroblasts and MINC cells. + + - - IL-1 alpha stimulates the phosphorylation of Erk1 in cardiac myofibroblast and mouse 3T3- L1 adipocytes. - + + IL-1 induced activation of mitogen-activated protein (MAP) kinase followed by activation of MAP kinase-activated protein (MAPKAP) kinase 2, a serine/threonine kinase, leading to subsequent phosphorylation of the small heat shock protein [27-kDa heat shock protein (Hsp27)]in primary monocytes and in the human monocytic leukemia cell line U-937. + - - IL-1 stimulates the activation and phosphorylation of IKK beta in alveolar macrophages from patients with chronic obstructive pulmonary disease(COPD) and MEF cells. + + Stimulation of the IL-1 receptor complex induces the phosphorylation and activation of MEKK1. - - IL-1 beta induces the phosphorylation of MEK in 3T3- L1 adipocytes . + + IL-1 stimulates the phosphorylation of PLCgamma-1 in human gingival fibroblasts. - - IL-1 stimulates the activation and phosphorylation of IKK alpha in alveolar macrophages from patients with chronic obstructive pulmonary disease(COPD) and MEF cells. - + + @@ -402,16 +403,13 @@ Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugo - - - - - - + + - - + + IL-1 stimulates the activation and phosphorylation of TAB1 in 293 cells. + @@ -419,32 +417,40 @@ Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugo - - + + IL-1 stimulates the phosphorylation of HSP27 in Hep G2 cells + - - IL-1 stimulation HSP27 activates MKK3 phosphorylation. - + + IL-1 stimulates the phosphorylation and activation of MAP2K7 + - - IL-1 stimulates SHP2 phosphorylation of a single tyrosine residue at 542 in human gingival fibroblasts. - + + - - IL-1 induced activation of mitogen-activated protein (MAP) kinase followed by activation of MAP kinase-activated protein (MAPKAP) kinase 2, a serine/threonine kinase, leading to subsequent phosphorylation of the small heat shock protein [27-kDa heat shock protein (Hsp27)]in primary monocytes and in the human monocytic leukemia cell line U-937. + + IL-1 stimulates the activation and phosphorylation of MKK6, thus activating the p38MAPK pathway in HeLa cells. + - - IL-1 stimulates the phosphorylation of Erk2 in human umbilical vein endothelial cells (HUVEC), COS7 cells and rat VSMCs and 3T3- L1 adipocytes. + + IL-1 alpha stimulates the phosphorylation of Erk1 in cardiac myofibroblast and mouse 3T3- L1 adipocytes. + + + + + IL-1 stimulates SHP2 phosphorylation of a single tyrosine residue at 542 in human gingival fibroblasts. - - + + IL-1 beta induces the phosphorylation of JNK2 in beta and MINC cells. + + @@ -452,57 +458,55 @@ Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugo - - IL-1 stimulates the phosphorylation of PLCgamma-1 in human gingival fibroblasts. - + + IL-1 stimulates the activation and phosphorylation of IKK alpha in alveolar macrophages from patients with chronic obstructive pulmonary disease(COPD) and MEF cells. + + - - IL-1 stimulates the activation and phosphorylation of MKK6, thus activating the p38MAPK pathway in HeLa cells. - + + IL-1 stimulation HSP27 activates MKK3 phosphorylation. + - - IL-1 beta induces the phosphorylation of JNK1 in beta rat synovial fibroblasts and MINC cells. - + + - - IL-1 beta induces the phosphorylation of JNK2 in beta and MINC cells. - + + - - Stimulation of the IL-1 receptor complex induces the phosphorylation and activation of MEKK1. - + + Stimulation of the IL-1 receptor complex induces the phosphorylation dependent activation of MEKK2. + - - IL-1 stimulates the phosphorylation and activation of MAP2K7 + + IL-1 beta induces the phosphorylation of MEK in 3T3- L1 adipocytes . - + + IL-1 stimulates the phosphorylation of Erk2 in human umbilical vein endothelial cells (HUVEC), COS7 cells and rat VSMCs and 3T3- L1 adipocytes. - - IL-1 stimulates the activation and phosphorylation of TAB1 in 293 cells. - + + - - IL-1 stimulates the phosphorylation and activation of MAP2K4 + + IL-1 stimulates the activation and phosphorylation of IKK beta in alveolar macrophages from patients with chronic obstructive pulmonary disease(COPD) and MEF cells. - - IL-1 beta stimulates the ubiquitination of TRAF6 in HeLa cells and in MEF cells. - + + @@ -540,438 +544,458 @@ Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugo - IL-1 stimulates the polyubiquitination of TAK1 by TRAF6 in mouse embryonic fibroblasts (MEF) cells. + IL-1 stimulates the polyubiquitination of TAK1 by TRAF6 in mouse embryonic fibroblasts (MEF) cells. + - - + + - IL-1 stimulates the interaction of activated IRAK1 with IL1R1 in human osteosarcoma cells and in human 293 cells upon IL-1 stimulation. - IL-1 stimulates the interaction of activated IRAK1 with IL-1RAcP in a constitutive manner in 293 cells and promotes signaling. + IL-1 stimulates the interaction of activated IRAK1 with IL1R1 in human osteosarcoma cells and in human 293 cells upon IL-1 stimulation. + + IL-1 stimulates the interaction of activated IRAK1 with IL-1RAcP in a constitutive manner in 293 cells and promotes signaling. + - - + + - - + + - IL-1 stimulates the recruitment of IRAK1 to IL-1 receptor complex, followed by interaction of activated IRAK1 with TRAF6 in 293T cells, leading to NFKB activation. + IL-1 stimulates the recruitment of IRAK1 to IL-1 receptor complex, followed by interaction of activated IRAK1 with TRAF6 in 293T cells, leading to NFKB activation. + - - + + - Type your comment here - - + + - - + + - - + + - - + + - - + + - IL-1 stimulates the ubiquitination of TAB3 by TRAF6 in 293 cells. + IL-1 stimulates the ubiquitination of TAB3 by TRAF6 in 293 cells. + - - + + - IL-1 stimulates the activation and phosphorylation of MKK6, thus activating the p38MAPK pathway in HeLa cells. + IL-1 stimulates the activation and phosphorylation of MKK6, thus activating the p38MAPK pathway in HeLa cells. + - - + + - IL-1 stimulates the phosphorylation of TOLLIP by activated IRAK1 in 293-Luc cells. + IL-1 stimulates the phosphorylation of TOLLIP by activated IRAK1 in 293-Luc cells. + - - + + - IL-1 stimulates the ubiquitination of TAB2 by TRAF6 in 293 cells. + IL-1 stimulates the ubiquitination of TAB2 by TRAF6 in 293 cells. + - - + + - - + + - IL-1 stimulates the recruitment of IRAK2 to IL-1 receptor complex, followed by interaction of activated IRAK2 with TRAF6 in 293T cells, leading to NFKB activation. + IL-1 stimulates the recruitment of IRAK2 to IL-1 receptor complex, followed by interaction of activated IRAK2 with TRAF6 in 293T cells, leading to NFKB activation. + - - + + IL-1 stimulates the phossphorylation of MKK3 in HeLa cells and the phosphorylation is activated by Hsp27. - - + + - - + + - - + + p65 NFKB(RELA) is phosphorylated by IKK beta upon IL-1 stimulation in HeLa cells. - - - + + + - - + + - - + + IL-1 stimulates the interaction of the adapter protein ECSIT with MEKK1 in 293 cells. - - + + - - + + - - + + - IL-1 stimulates the interaction of MAP3K3 and TRAF6 in mouse embryonic fibroblasts(MEF) cells. + IL-1 stimulates the interaction of MAP3K3 and TRAF6 in mouse embryonic fibroblasts(MEF) cells. + RING and zinc finger domains of TRAF6 were involved in the activation of MEKK3 - - + + - - + + - IL1A,IL1R1,IL1RAP,MYD88,IRAK4 forms a complex upon stimulation with IL-1 in mouse (EL4 6.1)cells. + IL1A,IL1R1,IL1RAP,MYD88,IRAK4 forms a complex upon stimulation with IL-1 in mouse (EL4 6.1)cells. + - - + + - IL-1 stimulates the interaction of activated IRAK4 with TRAF6 in 293 cells which results in the induction of NFKB activity. + IL-1 stimulates the interaction of activated IRAK4 with TRAF6 in 293 cells which results in the induction of NFKB activity. + - - + + - - + + - Type your comment here - - + + - IL-1 stimulates the phosphorylation of NIK by activated TAK1, followed by its association with IKK-alpha in 293 cells. Thus, TAK1 induced activation of IKK-alpha is achieved through activation of NIK. + IL-1 stimulates the phosphorylation of NIK by activated TAK1, followed by its association with IKK-alpha in 293 cells. Thus, TAK1 induced activation of IKK-alpha is achieved through activation of NIK. + - - + + IL-1 stimulated active IRAK1 phosphorylates IRAK2 in 293 cells. - - + + - - + + - - + + - IkappaB alpha (NFKBIA) undergoes phosphorylation upon IL-1 stimulation in HeLa cells. + IkappaB alpha (NFKBIA) undergoes phosphorylation upon IL-1 stimulation in HeLa cells. - - + + - - + + - - + + - - + + - - + + - - + + - - + + - IL-1 induces the recruitment of IRAK2 to receptor leading to interaction via NH2 terminal segment with cytoplasmic domain of Type I IL-1 receptor in 293 cells. + IL-1 induces the recruitment of IRAK2 to receptor leading to interaction via NH2 terminal segment with cytoplasmic domain of Type I IL-1 receptor in 293 cells. + - - - + + + - IL-1 stimulates the recruitment of MYD88 to the IL-1 receptor complex, further associates with IL-1RAcP in 293T cells which results in the induction of NFKB activity. + IL-1 stimulates the recruitment of MYD88 to the IL-1 receptor complex, further associates with IL-1RAcP in 293T cells which results in the induction of NFKB activity. + - - + + - IL-1 stimulates the interaction of IL-1RAcP with IL-1 alpha and type 1 IL-1 receptor complex in Sw3T3 fibroblasts and the CHO-IR/AcP cells. + IL-1 stimulates the interaction of IL-1RAcP with IL-1 alpha and type 1 IL-1 receptor complex in Sw3T3 fibroblasts and the CHO-IR/AcP cells. + - - + + - IL-1 stimulates the formation of a complex consisting of MAP3K3,TRAF6 and MAP3K7 in mouse embryonic fibroblasts cells. + IL-1 stimulates the formation of a complex consisting of MAP3K3,TRAF6 and MAP3K7 in mouse embryonic fibroblasts cells. + - - + + - IL-1 stimulates the interaction of ECSIT with TRAF6 and promotes TRAF6 dependent IRAK mediated activation of NFKB in 293T cells. + IL-1 stimulates the interaction of ECSIT with TRAF6 and promotes TRAF6 dependent IRAK mediated activation of NFKB in 293T cells. + - - + + - IL-1 stimulates the interaction of N-terminal domain of activated TRAF6 with PRKCZ in 293 cells. + IL-1 stimulates the interaction of N-terminal domain of activated TRAF6 with PRKCZ in 293 cells. + - - + + - - + + - IL-1 stimulates the recruitment of MYD88 to IL-1 functional receptor complex and subsequent association with underphosphorylated IRAK1 in 293 cells, thereby MYD88 participates in connecting receptors with a downstream kinase IRAK1. + IL-1 stimulates the recruitment of MYD88 to IL-1 functional receptor complex and subsequent association with underphosphorylated IRAK1 in 293 cells, thereby MYD88 participates in connecting receptors with a downstream kinase IRAK1. + - - + + - IL1 beta forms a complex with type I IL-1 receptor as shown by crystal structure analysis. - IL-1 stimulates the interaction of IL-1RAcP with IL-1 beta and type 1 IL-1 receptor complex in Sw3T3 fibroblasts and the CHO-IR/AcP cells. + IL1 beta forms a complex with type I IL-1 receptor as shown by crystal structure analysis. + + IL-1 stimulates the interaction of IL-1RAcP with IL-1 beta and type 1 IL-1 receptor complex in Sw3T3 fibroblasts and the CHO-IR/AcP cells. + - - + + - - - + + + - - + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + @@ -979,411 +1003,414 @@ Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugo - - + + - - - + + + - - - + + + - - - + + + - IL-1 stimulates the recruitment of TOLLIP to the IL-1 receptor complex where it binds with IL-1RAcP in HEK293T cells. - IL-1 stimulates the interaction of recruited TOLLIP with type I IL-1 receptor and IL-1RAcP through IRAK recruitment and activation in HEK293T cells. + IL-1 stimulates the recruitment of TOLLIP to the IL-1 receptor complex where it binds with IL-1RAcP in HEK293T cells. + + IL-1 stimulates the interaction of recruited TOLLIP with type I IL-1 receptor and IL-1RAcP through IRAK recruitment and activation in HEK293T cells. + - - - + + + NFKB activates MCP1 expression upon IL-1 stimulation. - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + @@ -1624,23 +1651,23 @@ Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugo - - - - - - - - - - - - + + + + + + + + + + + + - interleukin-1 signaling pathway - PW:0000883 + signaling pathway in the adaptive immune response + PW:0000820 Pathway Ontology @@ -1648,11 +1675,6 @@ Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugo PW:0000512 Pathway Ontology - - signaling pathway in the adaptive immune response - PW:0000820 - Pathway Ontology - 20067622 PubMed @@ -1700,5 +1722,16 @@ Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugo Leonard WJ Pandey A + + interleukin-1 signaling pathway + PW:0000883 + Pathway Ontology + + + interleukin-1 signaling pathway + PW:0000883 + Pathway Ontology + + diff --git a/pathways/WP3271/WP3271.json b/pathways/WP3271/WP3271.json index 519f31472..e1ff58037 100644 --- a/pathways/WP3271/WP3271.json +++ b/pathways/WP3271/WP3271.json @@ -16,7 +16,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a06a4", - "isPartOf": "d4388", + "isPartOf": "c2ceb", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -137,15 +137,13 @@ "gpmlElementName": "Interaction", "id": "a1b57", "kaavioType": "Edge", - "markerEnd": "MimInhibition", + "markerEnd": "TBar", "points": [ { - "id": "ef684", "x": 698, "y": 625 }, { - "id": "b2357", "x": 723, "y": 625 } @@ -154,7 +152,9 @@ "strokeWidth": 2, "type": [ "Interaction", - "Edge" + "Edge", + "SBO:0000169", + "Inhibition" ], "zIndex": 33643 }, @@ -186,7 +186,6 @@ 1 ] }, - "id": "e79d0", "isAttachedTo": "cf4ad", "orientation": [ 0, @@ -206,7 +205,6 @@ 0 ] }, - 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"isPartOf": "e7695", + "isPartOf": "b2cae", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2116,12 +2137,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "d264b", "x": 696, "y": 563 }, { - "id": "d1a95", "x": 753, "y": 563 } @@ -2148,7 +2167,7 @@ "gpmlElementName": "Shape", "height": 25, "id": "aed71", - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2186,7 +2205,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "af4c2", - "isPartOf": "ce3e4", + "isPartOf": "be30e", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2304,7 +2323,6 @@ 0.5 ] }, - "id": "c2498", "isAttachedTo": "bedd5", "orientation": [ 1, @@ -2324,7 +2342,6 @@ 0.5 ] }, - "id": "e4610", "isAttachedTo": "d712e", "orientation": [ 1, @@ -2347,6 +2364,35 @@ ], "zIndex": 12288 }, + "b043f": { + "contains": [ + "ac9e3", + "c6a8b" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "b043f", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 70, + "x": 527, + "y": 489, + "zIndex": 32768 + }, "b0bda": { "drawAs": "none", "fill": "transparent", @@ -2418,12 +2464,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "a7fff", "x": 184, "y": 1175 }, { - "id": "dfb49", "x": 185, "y": 1151 } @@ -2477,36 +2521,6 @@ "verticalAlign": "middle", "width": 15 }, - "b1090": { - "contains": [ - "a367b", - "bec0c", - "c19bf" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 36, - "id": "b1090", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 162, - "x": 431, - "y": 1088, - "zIndex": 32768 - }, "b1172": { "drawAs": "none", "fill": "transparent", @@ -2578,12 +2592,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "d77f1", "x": 573, "y": 1168 }, { - "id": "ad21f", "x": 573, "y": 1183 } @@ -2704,12 +2716,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "c0f5e", "x": 383.12022666666803, "y": 555.6666666666667 }, { - "id": "a8693", "x": 389.7868933333348, "y": 562.3333333333334 } @@ -2773,7 +2783,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b217a", - "isPartOf": "ce3e4", + "isPartOf": "be30e", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2814,12 +2824,10 @@ "markerEnd": "MimInhibition", "points": [ { - "id": "b61e2", "x": 697, "y": 909 }, { - "id": "a7ed7", "x": 762, "y": 909 } @@ -2832,6 +2840,35 @@ ], "zIndex": 33587 }, + "b2cae": { + "contains": [ + "ae4a7", + "cfff0" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "b2cae", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 66, + "x": 324, + "y": 446, + "zIndex": 32768 + }, "b2ef4": { "attachmentDisplay": { "offset": [ @@ -2928,7 +2965,6 @@ 0.5 ] }, - "id": "db3d4", "isAttachedTo": "cf4ad", "orientation": [ 1, @@ -2948,7 +2984,6 @@ 0 ] }, - "id": "a6067", "isAttachedTo": "db920", "orientation": [ 0, @@ -2999,7 +3034,6 @@ 0 ] }, - "id": "b8915", "isAttachedTo": "a359b", "orientation": [], "x": 333.3529411764706, @@ -3016,7 +3050,6 @@ 0 ] }, - "id": "d4c95", "isAttachedTo": "dbc27", "orientation": [ 0, @@ -3104,7 +3137,6 @@ 0 ] }, - "id": "c5c04", "isAttachedTo": "c1c4f", "orientation": [ 0, @@ -3124,7 +3156,6 @@ 1 ] }, - "id": "bed94", "isAttachedTo": "af4c2", "orientation": [ 0, @@ -3234,12 +3265,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "f645a", "x": 697, "y": 890.6570196866958 }, { - "id": "fd772", "x": 755, "y": 890.6570196866958 } @@ -3284,7 +3313,6 @@ 1 ] }, - "id": "e880e", "isAttachedTo": "f77df", "orientation": [ 0, @@ -3304,7 +3332,6 @@ 0 ] }, - "id": "fba3a", "isAttachedTo": "ab8b2", "orientation": [ 0, @@ -3326,37 +3353,6 @@ ], "zIndex": 12288 }, - "b6468": { - "contains": [ - "ab8b2", - "db920", - "efd2d", - "c5660" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 78, - "id": "b6468", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 130, - "x": 387, - "y": 765, - "zIndex": 32768 - }, "b6dbf": { "attachmentDisplay": { "offset": [ @@ -3468,7 +3464,6 @@ 1 ] }, - "id": "a0141", "isAttachedTo": "d712e", "orientation": [ 0, @@ -3488,7 +3483,6 @@ 0 ] }, - "id": "c069e", "isAttachedTo": "a5a3a", "orientation": [ 0, @@ -3520,12 +3514,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "a42d5", "x": 276, "y": 1175 }, { - "id": "c8d48", "x": 277, "y": 1151 } @@ -3573,10 +3565,11 @@ "y": 860, "zIndex": 33627 }, - "b792e": { + "b7c39": { "contains": [ - "ac9e3", - "c6a8b" + "a367b", + "bec0c", + "c19bf" ], "drawAs": "none", "fill": "transparent", @@ -3584,8 +3577,8 @@ "fontSize": 1, "fontWeight": "bold", "gpmlElementName": "Group", - "height": 56, - "id": "b792e", + "height": 36, + "id": "b7c39", "kaavioType": "Group", "padding": 8, "stroke": "#808080", @@ -3597,9 +3590,9 @@ "GroupGroup" ], "verticalAlign": "middle", - "width": 70, - "x": 527, - "y": 489, + "width": 162, + "x": 431, + "y": 1088, "zIndex": 32768 }, "b8049": { @@ -3642,12 +3635,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "f2f24", "x": 697, "y": 690.6593972779119 }, { - "id": "d4d2a", "x": 755, "y": 690.6593972779119 } @@ -3760,7 +3751,6 @@ 1 ] }, - "id": "b664e", "isAttachedTo": "fe64e", "orientation": [ 0, @@ -3780,7 +3770,6 @@ 0 ] }, - "id": "a6bdd", "isAttachedTo": "ae19d", "orientation": [ 0, @@ -3848,12 +3837,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "db58e", "x": 697, "y": 790.658208482304 }, { - "id": "ba76b", "x": 755, "y": 790.658208482304 } @@ -3870,49 +3857,6 @@ ], "zIndex": 33590 }, - "ba41a": { - "contains": [ - "c11d6", - "c2e36", - "f9af6", - "fec04", - "id2be2282a", - "aed71", - "ce844", - "e7333", - "ede13", - "f1a07", - "d9512", - "e2af7", - "e424b", - "eac9c", - "ed04f", - "f839a" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 169.14035087719304, - "id": "ba41a", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 293.5438596491227, - "x": 238.84210526315786, - "y": 230, - "zIndex": 12288 - }, "ba9f6": { "comments": [ { @@ -3969,12 +3913,10 @@ "kaavioType": "Edge", "points": [ { - "id": "fd682", "x": 723, "y": 557 }, { - "id": "b802f", "x": 723, "y": 569 } @@ -3996,12 +3938,10 @@ "markerEnd": "MimTranscriptionTranslation", "points": [ { - "id": "b16c1", "x": 696, "y": 602 }, { - "id": "b80eb", "x": 754, "y": 602 } @@ -4074,7 +4014,6 @@ 0 ] }, - "id": "eef08", "isAttachedTo": "a6625", "orientation": [], "x": 412.5764705882353, @@ -4091,7 +4030,6 @@ 0 ] }, - "id": "e0a5d", "isAttachedTo": "ca274", "orientation": [ 0, @@ -4154,12 +4092,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "fbb2a", "x": 743.3333333333335, "y": 650.3333333333326 }, { - "id": "c13d4", "x": 750, "y": 656.9999999999991 } @@ -4195,7 +4131,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bd5b2", - "isPartOf": "ab6a8", + "isPartOf": "c6d64", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4244,7 +4180,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bd5ca", - "isPartOf": "a2357", + "isPartOf": "bed7f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4276,6 +4212,35 @@ "y": 8, "zIndex": 32768 }, + "be30e": { + "contains": [ + "af4c2", + "b217a" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "be30e", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 69, + "x": 262, + "y": 446, + "zIndex": 32768 + }, "beb33": { "drawAs": "StraightLine", "fill": "none", @@ -4299,7 +4264,6 @@ 1 ] }, - "id": "a56f3", "isAttachedTo": "bedd5", "orientation": [ 0, @@ -4319,7 +4283,6 @@ 0 ] }, - "id": "f2d98", "isAttachedTo": "a9163", "orientation": [ 0, @@ -4361,7 +4324,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bec0c", - "isPartOf": "b1090", + "isPartOf": "b7c39", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4417,7 +4380,6 @@ 1 ] }, - "id": "e2920", "isAttachedTo": "eea63", "orientation": [ 0, @@ -4437,7 +4399,6 @@ 0 ] }, - "id": "c9539", "isAttachedTo": "f54dd", "orientation": [ 0, @@ -4460,6 +4421,35 @@ ], "zIndex": 12288 }, + "bed7f": { + "contains": [ + "bd5ca", + "c1945" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 36, + "id": "bed7f", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 125, + "x": 430, + "y": 1030, + "zIndex": 32768 + }, "bedd5": { "burrs": [ "b18ab" @@ -4652,12 +4642,12 @@ "DataNode", "SingleFreeNode", "Ensembl:ENSBTAG00000037811", - "RNA" + "Rna" ], "verticalAlign": "middle", "whiteSpace": "pre", "width": 47, - "wpType": "RNA", + "wpType": "Rna", "x": 481, "xrefDataSource": "Ensembl", "xrefIdentifier": "ENSBTAG00000037811", @@ -4673,12 +4663,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "d1999", "x": 697, "y": 750.6593972779119 }, { - "id": "e14e7", "x": 755, "y": 750.6593972779119 } @@ -4704,7 +4692,7 @@ "d9512", "f1a07" ], - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "Edge", "points": [ { @@ -4718,7 +4706,6 @@ 1 ] }, - "id": "d1195", "isAttachedTo": "d9512", "orientation": [ 0, @@ -4738,7 +4725,6 @@ 0 ] }, - "id": "c0ab5", "isAttachedTo": "f1a07", "orientation": [ 0, @@ -4791,36 +4777,7 @@ "Burr" ], "verticalAlign": "middle", - "width": 15 - }, - "c1510": { - "contains": [ - "f7ad4", - "ec1ff" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 57, - "id": "c1510", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 76, - "x": 132, - "y": 1204, - "zIndex": 33344 + "width": 15 }, "c1619": { "drawAs": "StraightLine", @@ -4831,12 +4788,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "dc95c", "x": 697, "y": 850.6570196866958 }, { - "id": "e0854", "x": 755, "y": 850.6570196866958 } @@ -4903,7 +4858,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c1945", - "isPartOf": "a2357", + "isPartOf": "bed7f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4954,7 +4909,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c19bf", - "isPartOf": "b1090", + "isPartOf": "b7c39", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5098,7 +5053,6 @@ 1 ] }, - "id": "a4ecd", "isAttachedTo": "bd5b2", "orientation": [ 0, @@ -5108,7 +5062,6 @@ "y": 983 }, { - "id": "de70f", "x": 536.25, "y": 983.8383838383838 }, @@ -5123,7 +5076,6 @@ 0 ] }, - "id": "a4fa5", "isAttachedTo": "bec0c", "orientation": [ 0, @@ -5154,12 +5106,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "c6df8", "x": 421.12022666666803, "y": 787.6666666666667 }, { - "id": "a6cfe", "x": 427.7868933333348, "y": 794.3333333333334 } @@ -5199,7 +5149,6 @@ 1 ] }, - "id": "f7673", "isAttachedTo": "eaf32", "orientation": [ 0, @@ -5219,7 +5168,6 @@ 0 ] }, - "id": "c69bf", "isAttachedTo": "ec1ff", "orientation": [ 0, @@ -5242,6 +5190,64 @@ ], "zIndex": 33338 }, + "c2c3a": { + "contains": [ + "ac6ca", + "d8e8d" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 58.5, + "id": "c2c3a", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 81, + "x": 559, + "y": 855, + "zIndex": 32768 + }, + "c2ceb": { + "contains": [ + "a06a4", + "ddb0f" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "c2ceb", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 73, + "x": 495, + "y": 817, + "zIndex": 32768 + }, "c2de7": { "burrs": [ "b89dc" @@ -5302,7 +5308,7 @@ "e424b", "aed71" ], - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "Edge", "points": [ { @@ -5316,7 +5322,6 @@ 1 ] }, - "id": "bfa74", "isAttachedTo": "e424b", "orientation": [ 0, @@ -5336,7 +5341,6 @@ 0 ] }, - "id": "aa170", "isAttachedTo": "aed71", "orientation": [ 0, @@ -5405,7 +5409,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c33b5", - "isPartOf": "ed25e", + "isPartOf": "e66f3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5438,35 +5442,6 @@ "y": 8, "zIndex": 32768 }, - "c344d": { - "contains": [ - "ac6ca", - "d8e8d" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 58.5, - "id": "c344d", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 81, - "x": 559, - "y": 855, - "zIndex": 32768 - }, "c3469": { "comments": [ { @@ -5536,7 +5511,6 @@ 1 ] }, - "id": "c17a2", "isAttachedTo": "a532d", "orientation": [ 0, @@ -5556,7 +5530,6 @@ 0 ] }, - "id": "ab92b", "isAttachedTo": "cae59", "orientation": [ 0, @@ -5614,12 +5587,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "dec12", "x": 519, "y": 1168 }, { - "id": "b6de6", "x": 519, "y": 1183 } @@ -5655,7 +5626,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c5660", - "isPartOf": "b6468", + "isPartOf": "a239a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5754,7 +5725,6 @@ 1 ] }, - "id": "c33d5", "isAttachedTo": "b54e0", "orientation": [ 0, @@ -5774,7 +5744,6 @@ 0 ] }, - "id": "f472d", "isAttachedTo": "eea63", "orientation": [ 0, @@ -5836,12 +5805,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "b5b5e", "x": 529.120226666668, "y": 555.6666666666667 }, { - "id": "e3d88", "x": 535.7868933333348, "y": 562.3333333333334 } @@ -5874,7 +5841,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c6a8b", - "isPartOf": "b792e", + "isPartOf": "b043f", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -5908,6 +5875,37 @@ "y": 8, "zIndex": 32768 }, + "c6d64": { + "contains": [ + "a6dbb", + "bd5b2", + "cfe0e", + "f7e24" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "c6d64", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 107, + "x": 427, + "y": 955, + "zIndex": 32768 + }, "c6f02": { "drawAs": "none", "fill": "transparent", @@ -6016,12 +6014,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "e1317", "x": 697, "y": 670 }, { - "id": "ca6f2", "x": 755.0000017000198, "y": 670.6593972779119 } @@ -6039,6 +6035,9 @@ "zIndex": 33594 }, "c9abe": { + "comments": [ + {} + ], "drawAs": "StraightLine", "fill": "none", "gpmlElementName": "Interaction", @@ -6061,7 +6060,6 @@ 0.5 ] }, - "id": "be120", "isAttachedTo": "f06cc", "orientation": [ -1, @@ -6081,7 +6079,6 @@ 0.5 ] }, - "id": "d5531", "isAttachedTo": "d07b4", "orientation": [ -1, @@ -6202,12 +6199,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "ea72d", "x": 698, "y": 929 }, { - "id": "d2873", "x": 756, "y": 929.5012759336341 } @@ -6234,12 +6229,10 @@ "markerEnd": "MimTranscriptionTranslation", "points": [ { - "id": "a4be1", "x": 722, "y": 625 }, { - "id": "c5fc2", "x": 755, "y": 625 } @@ -6337,7 +6330,6 @@ 1 ] }, - "id": "a96e0", "isAttachedTo": "ef92b", "orientation": [ 0, @@ -6357,7 +6349,6 @@ 0 ] }, - "id": "fc605", "isAttachedTo": "dbc27", "orientation": [ 0, @@ -6434,7 +6425,6 @@ 1 ] }, - "id": "af88c", "isAttachedTo": "a9163", "orientation": [ 0, @@ -6454,7 +6444,6 @@ 0 ] }, - "id": "f2234", "isAttachedTo": "f06cc", "orientation": [ 0, @@ -6476,35 +6465,6 @@ ], "zIndex": 12288 }, - "ce3e4": { - "contains": [ - "af4c2", - "b217a" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "ce3e4", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 69, - "x": 262, - "y": 446, - "zIndex": 32768 - }, "ce844": { "drawAs": "ArcPathVisio", "fill": "#3300ff", @@ -6515,7 +6475,7 @@ "gpmlElementName": "Shape", "height": 30, "id": "ce844", - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6546,12 +6506,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "c9347", "x": 479.12022666666803, "y": 447.66666666666674 }, { - "id": "cfc79", "x": 485.7868933333348, "y": 454.33333333333337 } @@ -6679,7 +6637,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "cfe0e", - "isPartOf": "ab6a8", + "isPartOf": "c6d64", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6727,7 +6685,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "cfff0", - "isPartOf": "e7695", + "isPartOf": "b2cae", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -6769,12 +6727,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "f1f11", "x": 751, "y": 994 }, { - "id": "a94b3", "x": 751, "y": 1009 } @@ -6850,12 +6806,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "cd399", "x": 185, "y": 1168 }, { - "id": "ba7d2", "x": 185, "y": 1183 } @@ -6934,7 +6888,6 @@ 1 ] }, - "id": "e2903", "isAttachedTo": "d9207", "orientation": [ 0, @@ -6954,7 +6907,6 @@ 0 ] }, - "id": "f0f5a", "isAttachedTo": "ef92b", "orientation": [ 0, @@ -6985,12 +6937,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "afcc8", "x": 518, "y": 1175 }, { - "id": "db5d0", "x": 519, "y": 1151 } @@ -7156,35 +7106,6 @@ "verticalAlign": "middle", "width": 15 }, - "d4388": { - "contains": [ - "a06a4", - "ddb0f" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "d4388", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 73, - "x": 495, - "y": 817, - "zIndex": 32768 - }, "d54bb": { "drawAs": "rect", "fill": "#ffffff", @@ -7404,7 +7325,6 @@ 0.5 ] }, - "id": "f9248", "isAttachedTo": "cfff0", "orientation": [ 1, @@ -7424,7 +7344,6 @@ 0.5 ] }, - "id": "d234f", "isAttachedTo": "bf0bd", "orientation": [ 1, @@ -7546,7 +7465,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "d8b28", - "isPartOf": "ed25e", + "isPartOf": "e66f3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7633,7 +7552,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "d8e8d", - "isPartOf": "c344d", + "isPartOf": "c2c3a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7778,7 +7697,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "d9512", - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -7852,12 +7771,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "ced6c", "x": 696, "y": 544 }, { - "id": "c34bf", "x": 754, "y": 544 } @@ -7902,7 +7819,6 @@ 1 ] }, - "id": "de1c4", "isAttachedTo": "bf0bd", "orientation": [ 0, @@ -7922,7 +7838,6 @@ 0 ] }, - "id": "edb35", "isAttachedTo": "f77df", "orientation": [ 0, @@ -7990,12 +7905,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "d29eb", "x": 472, "y": 1175 }, { - "id": "bdbb0", "x": 473, "y": 1151 } @@ -8028,7 +7941,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "db920", - "isPartOf": "b6468", + "isPartOf": "a239a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8072,12 +7985,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "cd8b5", "x": 697, "y": 730.6593972779119 }, { - "id": "e6e79", "x": 755, "y": 730.6593972779119 } @@ -8187,12 +8098,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "ec512", "x": 697, "y": 830.6570196866958 }, { - "id": "a0b80", "x": 755, "y": 830.6570196866958 } @@ -8355,7 +8264,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "ddb0f", - "isPartOf": "d4388", + "isPartOf": "c2ceb", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8565,7 +8474,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e2af7", - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8632,11 +8541,6 @@ "zIndex": 33617 }, "e3841": { - "comments": [ - { - "content": "Type your comment here" - } - ], "drawAs": "StraightLine", "fill": "none", "gpmlElementName": "Interaction", @@ -8659,7 +8563,6 @@ 0.5 ] }, - "id": "caebb", "isAttachedTo": "c1c4f", "orientation": [ 1, @@ -8679,7 +8582,6 @@ 0.5 ] }, - "id": "c578a", "isAttachedTo": "b6f6f", "orientation": [ 1, @@ -8749,7 +8651,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e424b", - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8840,7 +8742,6 @@ 1 ] }, - "id": "d3bf2", "isAttachedTo": "aba92", "orientation": [ 0, @@ -8860,7 +8761,6 @@ 0 ] }, - "id": "f76ba", "isAttachedTo": "bd5b2", "orientation": [ 0, @@ -8901,7 +8801,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e5522", - "isPartOf": "ed25e", + "isPartOf": "e66f3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -8961,7 +8861,6 @@ 0.5 ] }, - "id": "b293a", "isAttachedTo": "c1c4f", "orientation": [ -1, @@ -8981,7 +8880,6 @@ 0.5 ] }, - "id": "a81ee", "isAttachedTo": "fe64e", "orientation": [ -1, @@ -9003,6 +8901,36 @@ ], "zIndex": 12288 }, + "e66f3": { + "contains": [ + "c33b5", + "d8b28", + "e5522" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 36, + "id": "e66f3", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 162, + "x": 431, + "y": 1222, + "zIndex": 32768 + }, "e69b7": { "drawAs": "none", "fill": "transparent", @@ -9069,7 +8997,7 @@ "gpmlElementName": "Shape", "height": 39.798245614035224, "id": "e7333", - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9146,35 +9074,6 @@ "y": 1062, "zIndex": 32768 }, - "e7695": { - "contains": [ - "ae4a7", - "cfff0" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "e7695", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 66, - "x": 324, - "y": 446, - "zIndex": 32768 - }, "e7941": { "drawAs": "StraightLine", "fill": "none", @@ -9198,7 +9097,6 @@ 1 ] }, - "id": "a437a", "isAttachedTo": "d2e9d", "orientation": [ 0, @@ -9218,7 +9116,6 @@ 0 ] }, - "id": "ff84d", "isAttachedTo": "d91d6", "orientation": [ 0, @@ -9301,7 +9198,6 @@ 1 ] }, - "id": "b3d0d", "isAttachedTo": "a98e3", "orientation": [ 0, @@ -9321,7 +9217,6 @@ 0 ] }, - "id": "b4c76", "isAttachedTo": "ac6ca", "orientation": [ 0, @@ -9409,7 +9304,6 @@ 0.5 ] }, - "id": "e82d3", "isAttachedTo": "a6dbb", "orientation": [ -1, @@ -9429,7 +9323,6 @@ 0 ] }, - "id": "c7cb2", "isAttachedTo": "c1945", "orientation": [ 0, @@ -9467,7 +9360,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "eac9c", - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9601,7 +9494,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "ec1ff", - "isPartOf": "c1510", + "isPartOf": "a34c3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9659,7 +9552,6 @@ 1 ] }, - "id": "c57ef", "isAttachedTo": "d91d6", "orientation": [ 0, @@ -9679,7 +9571,6 @@ 0 ] }, - "id": "a2c90", "isAttachedTo": "a98e3", "orientation": [ 0, @@ -9725,7 +9616,6 @@ 1 ] }, - "id": "a3a76", "isAttachedTo": "ac9e3", "orientation": [ 0, @@ -9745,7 +9635,6 @@ 0 ] }, - "id": "ea0bf", "isAttachedTo": "c2de7", "orientation": [ 0, @@ -9784,7 +9673,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "ed04f", - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -9819,36 +9708,6 @@ "y": 131.5, "zIndex": 32768 }, - "ed25e": { - "contains": [ - "c33b5", - "d8b28", - "e5522" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 36, - "id": "ed25e", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 162, - "x": 431, - "y": 1222, - "zIndex": 32768 - }, "ed51c": { "comments": [ { @@ -9921,7 +9780,6 @@ 1 ] }, - "id": "add31", "isAttachedTo": "bec0c", "orientation": [ 0, @@ -9941,7 +9799,6 @@ 0 ] }, - "id": "b5d37", "isAttachedTo": "d8b28", "orientation": [ 0, @@ -9974,7 +9831,7 @@ "gpmlElementName": "Shape", "height": 30, "id": "ede13", - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -10005,12 +9862,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "c0e4d", "x": 277, "y": 1168 }, { - "id": "ac5a8", "x": 277, "y": 1183 } @@ -10260,7 +10115,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "efd2d", - "isPartOf": "b6468", + "isPartOf": "a239a", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -10302,12 +10157,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "d6817", "x": 572, "y": 1175 }, { - "id": "c9de7", "x": 573, "y": 1151 } @@ -10416,7 +10269,7 @@ "gpmlElementName": "Shape", "height": 25, "id": "f1a07", - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -10461,7 +10314,6 @@ 1 ] }, - "id": "f0d01", "isAttachedTo": "f7ad4", "orientation": [ 0, @@ -10481,7 +10333,6 @@ 0 ] }, - "id": "e0664", "isAttachedTo": "d07b4", "orientation": [ 0, @@ -10580,12 +10431,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "a61ed", "x": 697, "y": 810 }, { - "id": "fe295", "x": 755, "y": 810.5024647292423 } @@ -10643,12 +10492,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "eec88", "x": 696, "y": 584 }, { - "id": "cc0ae", "x": 754, "y": 584 } @@ -10720,7 +10567,6 @@ 1 ] }, - "id": "e014a", "isAttachedTo": "d8e8d", "orientation": [ 0, @@ -10740,7 +10586,6 @@ 0 ] }, - "id": "d2706", "isAttachedTo": "d7f2f", "orientation": [ 0, @@ -10857,7 +10702,7 @@ "gpmlElementName": "Interaction", "id": "f7644", "isAttachedTo": [ - "ba41a", + "acd41", "fe64e" ], "kaavioType": "Edge", @@ -10874,17 +10719,15 @@ 1 ] }, - "id": "d55b2", - "isAttachedTo": "ba41a", + "isAttachedTo": "acd41", "orientation": [ 0, 1 ], "x": 312.2280701754386, - "y": 399.14035087719304 + "y": 399.140350877193 }, { - "id": "fbe81", "x": 286.3640350877193, "y": 411.4035087719298 }, @@ -10899,7 +10742,6 @@ 0 ] }, - "id": "f3550", "isAttachedTo": "fe64e", "orientation": [ 0, @@ -11021,7 +10863,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f7ad4", - "isPartOf": "c1510", + "isPartOf": "a34c3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -11071,7 +10913,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f7e24", - "isPartOf": "ab6a8", + "isPartOf": "c6d64", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -11114,7 +10956,7 @@ "gpmlElementName": "Interaction", "id": "f80ad", "isAttachedTo": [ - "ba41a", + "acd41", "cfff0" ], "kaavioType": "Edge", @@ -11131,18 +10973,17 @@ 1 ] }, - "id": "eb04a", - "isAttachedTo": "ba41a", + "isAttachedTo": "acd41", "orientation": [ 0, 1 ], "x": 385.61403508771923, - "y": 399.14035087719304 + "y": 399.140350877193 }, { "x": 371.3070175438596, - "y": 419.14035087719304 + "y": 419.140350877193 }, { "attachmentDisplay": { @@ -11155,7 +10996,6 @@ 0 ] }, - "id": "ff621", "isAttachedTo": "cfff0", "orientation": [ 0, @@ -11224,7 +11064,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f839a", - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -11265,12 +11105,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "fec00", "x": 697, "y": 870.6570196866958 }, { - "id": "dab5e", "x": 755, "y": 870.6570196866958 } @@ -11332,7 +11170,7 @@ "ede13", "eac9c" ], - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "Edge", "points": [ { @@ -11346,7 +11184,6 @@ 1 ] }, - "id": "ace26", "isAttachedTo": "ede13", "orientation": [ 0, @@ -11366,7 +11203,6 @@ 0 ] }, - "id": "f8649", "isAttachedTo": "eac9c", "orientation": [ 0, @@ -11412,7 +11248,6 @@ 0.5 ] }, - "id": "ed9c0", "isAttachedTo": "c5660", "orientation": [ -1, @@ -11432,7 +11267,6 @@ 0.5 ] }, - "id": "e0b81", "isAttachedTo": "ef92b", "orientation": [ -1, @@ -11519,7 +11353,6 @@ 1 ] }, - "id": "ad938", "isAttachedTo": "ae19d", "orientation": [ 0, @@ -11539,7 +11372,6 @@ 0 ] }, - "id": "b2b04", "isAttachedTo": "b54e0", "orientation": [ 0, @@ -11589,7 +11421,6 @@ 0.5 ] }, - "id": "e9154", "isAttachedTo": "f77df", "orientation": [ 1, @@ -11609,7 +11440,6 @@ 0.5 ] }, - "id": "c4d99", "isAttachedTo": "a6fa8", "orientation": [ 1, @@ -11702,12 +11532,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "a6cd9", "x": 473, "y": 1168 }, { - "id": "c65b1", "x": 473, "y": 1183 } @@ -11752,7 +11580,6 @@ 1 ] }, - "id": "c4406", "isAttachedTo": "ae4a7", "orientation": [ 0, @@ -11772,7 +11599,6 @@ 0 ] }, - "id": "c4c35", "isAttachedTo": "c1c4f", "orientation": [ 0, @@ -11884,12 +11710,10 @@ "markerEnd": "Arrow", "points": [ { - "id": "ea091", "x": 697, "y": 710.6593972779119 }, { - "id": "e98df", "x": 755, "y": 710.6593972779119 } @@ -11918,7 +11742,6 @@ "markerEnd": "Arrow", "points": [ { - "id": "ed79d", "x": 248.56322810966947, "y": 555.1856661856663 }, @@ -11933,7 +11756,6 @@ 0 ] }, - "id": "fbb3b", "isAttachedTo": "fe64e", "orientation": [ 0, @@ -11972,7 +11794,7 @@ "ce844", "f839a" ], - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "Edge", "points": [ { @@ -11986,7 +11808,6 @@ 1 ] }, - "id": "bfd84", "isAttachedTo": "ce844", "orientation": [ 0, @@ -12006,7 +11827,6 @@ 0 ] }, - "id": "b956b", "isAttachedTo": "f839a", "orientation": [ 0, @@ -12177,7 +11997,6 @@ 1 ] }, - "id": "cef12", "isAttachedTo": "ef92b", "orientation": [ 0, @@ -12187,7 +12006,6 @@ "y": 814 }, { - "id": "c8cbd", "x": 244.5, "y": 888 }, @@ -12202,7 +12020,6 @@ 0 ] }, - "id": "d0f1f", "isAttachedTo": "eeb2d", "orientation": [ 0, @@ -12248,7 +12065,6 @@ 0.5 ] }, - "id": "cafd0", "isAttachedTo": "c1945", "orientation": [ 1, @@ -12268,7 +12084,6 @@ 0 ] }, - "id": "e9589", "isAttachedTo": "c19bf", "orientation": [ 0, @@ -12313,7 +12128,6 @@ 1 ] }, - "id": "a8f1c", "isAttachedTo": "dbc27", "orientation": [ 0, @@ -12323,7 +12137,6 @@ "y": 983 }, { - "id": "bbb9e", "x": 289, "y": 1010 }, @@ -12338,7 +12151,6 @@ 0 ] }, - "id": "eddcc", "isAttachedTo": "bedd5", "orientation": [ 0, @@ -12366,16 +12178,14 @@ "fill": "none", "gpmlElementName": "Interaction", "id": "id2be2282a", - "isPartOf": "ba41a", + "isPartOf": "acd41", "kaavioType": "Edge", "points": [ { - "id": "b4bc9", "x": 146.15789473684214, "y": 125 }, { - "id": "e1962", "x": 146.15789473684214, "y": 155 } @@ -12411,7 +12221,6 @@ 1 ] }, - "id": "c8b80", "isAttachedTo": "ae4a7", "orientation": [ 0, @@ -12421,7 +12230,6 @@ "y": 494 }, { - "id": "e1d09", "x": 309.875, "y": 531 }, @@ -12436,7 +12244,6 @@ 0 ] }, - "id": "c343d", "isAttachedTo": "fe64e", "orientation": [ 0, @@ -12481,7 +12288,6 @@ 1 ] }, - "id": "a577c", "isAttachedTo": "c5660", "orientation": [ 0, @@ -12491,7 +12297,6 @@ "y": 814 }, { - "id": "a8853", "x": 475.625, "y": 877 }, @@ -12506,7 +12311,6 @@ 0 ] }, - "id": "bbc38", "isAttachedTo": "aba92", "orientation": [ 0, @@ -12555,7 +12359,6 @@ 1 ] }, - "id": "b0439", "isAttachedTo": "c5660", "orientation": [ 0, @@ -12565,7 +12368,6 @@ "y": 814 }, { - "id": "ecc9b", "x": 344.75, "y": 900 }, @@ -12580,7 +12382,6 @@ 0 ] }, - "id": "b4a08", "isAttachedTo": "f54dd", "orientation": [ 0, @@ -12626,7 +12427,6 @@ 0.5 ] }, - "id": "cbd28", "isAttachedTo": "ae19d", "orientation": [ -1, @@ -12646,7 +12446,6 @@ 0 ] }, - "id": "b73cf", "isAttachedTo": "ba9f6", "orientation": [ 0, @@ -12674,7 +12473,7 @@ "gpmlElementName": "Interaction", "id": "id721d146d", "isAttachedTo": [ - "ba41a", + "acd41", "d2e9d" ], "kaavioType": "Edge", @@ -12691,17 +12490,15 @@ 1 ] }, - "id": "f7b4e", - "isAttachedTo": "ba41a", + "isAttachedTo": "acd41", "orientation": [ 0, 1 ], "x": 458.9999999999999, - "y": 399.14035087719304 + "y": 399.140350877193 }, { - "id": "c224f", "x": 523.25, "y": 400.35087719298247 }, @@ -12716,7 +12513,6 @@ 0 ] }, - "id": "ef89e", "isAttachedTo": "d2e9d", "orientation": [ 0, @@ -12762,7 +12558,6 @@ 1 ] }, - "id": "a61c3", "isAttachedTo": "c1c4f", "orientation": [ 0, @@ -12772,7 +12567,6 @@ "y": 582 }, { - "id": "f01ea", "x": 408.625, "y": 605 }, @@ -12787,7 +12581,6 @@ 0 ] }, - "id": "aaae0", "isAttachedTo": "cfddc", "orientation": [ 0, @@ -12832,7 +12625,6 @@ 1 ] }, - "id": "ef12e", "isAttachedTo": "c1c4f", "orientation": [ 0, @@ -12842,7 +12634,6 @@ "y": 582 }, { - "id": "c560f", "x": 348.75, "y": 605 }, @@ -12857,7 +12648,6 @@ 0 ] }, - "id": "d6ab4", "isAttachedTo": "ed51c", "orientation": [ 0, @@ -12893,7 +12683,7 @@ "gpmlElementName": "Interaction", "id": "id97dc4493", "isAttachedTo": [ - "ba41a", + "acd41", "b217a" ], "kaavioType": "Edge", @@ -12910,17 +12700,15 @@ 1 ] }, - "id": "d6bf4", - "isAttachedTo": "ba41a", + "isAttachedTo": "acd41", "orientation": [ 0, 1 ], "x": 312.2280701754386, - "y": 399.14035087719304 + "y": 399.140350877193 }, { - "id": "fd199", "x": 304.3640350877193, "y": 411.4035087719298 }, @@ -12935,7 +12723,6 @@ 0 ] }, - "id": "f2d2b", "isAttachedTo": "b217a", "orientation": [ 0, @@ -12985,7 +12772,6 @@ 1 ] }, - "id": "bcf85", "isAttachedTo": "c33b5", "orientation": [ 0, @@ -13005,7 +12791,6 @@ 0 ] }, - "id": "bfc52", "isAttachedTo": "bfec9", "orientation": [ 0, @@ -13049,7 +12834,6 @@ 1 ] }, - "id": "bac4f", "isAttachedTo": "a1150", "orientation": [ 0, @@ -13059,7 +12843,6 @@ "y": 814 }, { - "id": "a398e", "x": 203.5, "y": 877 }, @@ -13074,7 +12857,6 @@ 0 ] }, - "id": "ecd8d", "isAttachedTo": "f54dd", "orientation": [ 0, @@ -13120,7 +12902,6 @@ 0 ] }, - "id": "e3428", "isAttachedTo": "a276c", "orientation": [ 0, @@ -13130,7 +12911,6 @@ "y": 888 }, { - "id": "b65ef", "x": 420.67883927131646, "y": 888 }, @@ -13145,7 +12925,6 @@ 0 ] }, - "id": "b8f2e", "isAttachedTo": "f7e24", "orientation": [ 0, @@ -13191,7 +12970,6 @@ 1 ] }, - "id": "c8047", "isAttachedTo": "eea63", "orientation": [ 0, @@ -13201,7 +12979,6 @@ "y": 814 }, { - "id": "d7384", "x": 200, "y": 865 }, @@ -13216,7 +12993,6 @@ 0 ] }, - "id": "ba2f1", "isAttachedTo": "eeb2d", "orientation": [ 0, @@ -13262,7 +13038,6 @@ 1 ] }, - "id": "e9b99", "isAttachedTo": "ca274", "orientation": [ 0, @@ -13272,7 +13047,6 @@ "y": 982 }, { - "id": "de1c2", "x": 336.5, "y": 1025 }, @@ -13287,7 +13061,6 @@ 0 ] }, - "id": "d3f9f", "isAttachedTo": "bedd5", "orientation": [ 0, @@ -13333,7 +13106,6 @@ 1 ] }, - "id": "f3238", "isAttachedTo": "f54dd", "orientation": [ 0, @@ -13343,7 +13115,6 @@ "y": 981 }, { - "id": "a0f71", "x": 207, "y": 1011 }, @@ -13358,7 +13129,6 @@ 0 ] }, - "id": "aa20b", "isAttachedTo": "e73b2", "orientation": [ 0, @@ -13404,7 +13174,6 @@ 1 ] }, - "id": "df75d", "isAttachedTo": "c19bf", "orientation": [ 0, @@ -13424,7 +13193,6 @@ 0 ] }, - "id": "a02d1", "isAttachedTo": "c33b5", "orientation": [ 0, @@ -13470,7 +13238,6 @@ 1 ] }, - "id": "b3144", "isAttachedTo": "bf0bd", "orientation": [ 0, @@ -13480,7 +13247,6 @@ "y": 474 }, { - "id": "e8998", "x": 450.75, "y": 556 }, @@ -13495,7 +13261,6 @@ 0 ] }, - "id": "c5465", "isAttachedTo": "cfddc", "orientation": [ 0, @@ -13543,7 +13308,6 @@ 1 ] }, - "id": "a5aa6", "isAttachedTo": "ef92b", "orientation": [ 0, @@ -13553,7 +13317,6 @@ "y": 814 }, { - "id": "f268e", "x": 365.125, "y": 888 }, @@ -13568,7 +13331,6 @@ 0 ] }, - "id": "de123", "isAttachedTo": "ca274", "orientation": [ 0, @@ -13615,7 +13377,6 @@ 0 ] }, - "id": "bc8a1", "isAttachedTo": "e6f2c", "orientation": [ -1, @@ -13625,7 +13386,6 @@ "y": 877 }, { - "id": "cfc61", "x": 168.30139405204463, "y": 877 }, @@ -13640,7 +13400,6 @@ 0 ] }, - "id": "d8f11", "isAttachedTo": "eeb2d", "orientation": [ 0, @@ -13668,7 +13427,7 @@ "gpmlElementName": "Interaction", "id": "idd983e8fd", "isAttachedTo": [ - "ba41a", + "acd41", "c6a8b" ], "kaavioType": "Edge", @@ -13685,18 +13444,17 @@ 1 ] }, - "id": "e3a4a", - "isAttachedTo": "ba41a", + "isAttachedTo": "acd41", "orientation": [ 0, 1 ], "x": 458.9999999999999, - "y": 399.14035087719304 + "y": 399.140350877193 }, { "x": 503.74999999999994, - "y": 419.14035087719304 + "y": 419.140350877193 }, { "attachmentDisplay": { @@ -13709,7 +13467,6 @@ 0 ] }, - "id": "a6655", "isAttachedTo": "c6a8b", "orientation": [ 0, @@ -13739,12 +13496,10 @@ "kaavioType": "Edge", "points": [ { - "id": "e9044", "x": 484, "y": 1076 }, { - "id": "a035e", "x": 499, "y": 1076 } @@ -13780,7 +13535,6 @@ 0 ] }, - "id": "aa215", "isAttachedTo": "a06a4", "orientation": [ 0, @@ -13790,7 +13544,6 @@ "y": 825 }, { - "id": "b53a8", "x": 519.375, "y": 759 }, @@ -13805,7 +13558,6 @@ 1 ] }, - "id": "a46c9", "isAttachedTo": "f77df", "orientation": [ 0, @@ -13888,7 +13640,7 @@ "@context": [ "https://cdn.rawgit.com/wikipathways/WpVocabularies/7a46a05/contexts/pvjs.jsonld", { - "@base": "http://identifiers.org/wikipathways/WP3271/" + "@base": "WP3271/" } ], "author": "[Mkutmon, MaintBot, Egonw]", @@ -13967,7 +13719,7 @@ "idd3196d5f", "idf8fcd60", "idfa124209", - "ba41a", + "acd41", "a40da", "f7644", "f80ad", @@ -14013,16 +13765,16 @@ "ef92b", "f54dd", "f77df", - "b6468", - "b792e", - "e7695", - "b1090", - "ce3e4", - "a2357", - "c344d", - "d4388", - "ab6a8", - "ed25e", + "a239a", + "b043f", + "b2cae", + "b7c39", + "be30e", + "bed7f", + "c2c3a", + "c2ceb", + "c6d64", + "e66f3", "cf470", "d6081", "bf0bd", @@ -14043,7 +13795,7 @@ "a9163", "d07b4", "f06cc", - "c1510", + "a34c3", "b72ac", "d0c8c", "ee77c", @@ -14129,7 +13881,7 @@ "a57ea", "d8bab" ], - "dataSourceVersion": "WP3271_r115997", + "dataSourceVersion": "WP3271_r134268", "displayName": "IL-1 signaling pathway", "drawAs": "rect", "fill": "white", @@ -14137,9 +13889,9 @@ "fontWeight": "bold", "gpmlElementName": "Pathway", "height": 1363, - "id": "http://identifiers.org/wikipathways/WP3271", + "id": "WP3271", "kaavioType": "Group", - "lastModified": "20210328155303", + "lastModified": "20240719064327", "name": "IL-1 signaling pathway", "organism": "Bos taurus", "padding": 5, @@ -14148,12 +13900,13 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: IL-1 signaling pathway\nLast Modified: 20210328155303\nOrganism: Bos taurus", + "textContent": "Name: IL-1 signaling pathway\nLast Modified: 20240719064327\nOrganism: Bos taurus", "type": [ "Pathway", - "http://identifiers.org/pw/PW:0000883", + "http://identifiers.org/pw/PW:0000820", "http://identifiers.org/pw/PW:0000512", - "http://identifiers.org/pw/PW:0000820" + "http://identifiers.org/pw/PW:0000883", + "http://identifiers.org/pw/PW:0000883" ], "verticalAlign": "top", "width": 1067, diff --git a/pathways/WP3271/WP3271.png b/pathways/WP3271/WP3271.png index 39cfe3df3..d908c774f 100644 Binary files a/pathways/WP3271/WP3271.png and b/pathways/WP3271/WP3271.png differ diff --git a/pathways/WP3271/WP3271.svg b/pathways/WP3271/WP3271.svg index 85e5d9313..088f8b2fa 100644 --- a/pathways/WP3271/WP3271.svg +++ b/pathways/WP3271/WP3271.svg @@ -1,5 +1,5 @@ - + @@ -70,11 +70,11 @@ - - + + - - + + @@ -82,11 +82,11 @@ - - + + - - + + @@ -592,8 +592,8 @@ - - + + @@ -926,8 +926,8 @@ - - + + @@ -1006,33 +1006,33 @@ - - + + - - + + - - + + - + - - + + - - + + @@ -1173,7 +1173,7 @@ MAPK14 - + CCL2 @@ -1377,8 +1377,8 @@ TRAF6 - - + + @@ -1416,8 +1416,8 @@ - - + + @@ -1431,8 +1431,8 @@ - - + + @@ -1446,8 +1446,8 @@ - - + + @@ -1485,8 +1485,8 @@ - - + + @@ -1500,8 +1500,8 @@ - - + + @@ -1521,8 +1521,8 @@ - - + + @@ -1548,8 +1548,8 @@ - - + + @@ -1563,8 +1563,8 @@ - - + + @@ -1602,8 +1602,8 @@ - - + + @@ -1762,8 +1762,8 @@ ATF2 - - + + @@ -2171,9 +2171,9 @@ - + - + @@ -2248,9 +2248,9 @@ - + Name: IL-1 signaling pathway - Last Modified: 20210328155303 + Last Modified: 20240719064327 Organism: Bos taurus diff --git a/pathways/WP3529/WP3529-bibliography.tsv b/pathways/WP3529/WP3529-bibliography.tsv index 727ea7395..6e982ab9e 100644 --- a/pathways/WP3529/WP3529-bibliography.tsv +++ b/pathways/WP3529/WP3529-bibliography.tsv @@ -1,10 +1,10 @@ ID Database Citation -10755665 Pubmed "Miles AT, Hawksworth GM, Beattie JH, Rodilla V. Induction, regulation, degradation, and biological significance of mammalian metallothioneins. Crit Rev Biochem Mol Biol. 2000;35(1):35–70. PubMed Europe PMC Scholia" -11831458 Pubmed "Andrews GK. Cellular zinc sensors: MTF-1 regulation of gene expression. Biometals. 2001;14(3–4):223–37. PubMed Europe PMC Scholia" -17344318 Pubmed "Chen Y-H, Yang CK, Xia M, Ou C-Y, Stallcup MR. Role of GAC63 in transcriptional activation mediated by beta-catenin. Nucleic Acids Res. 2007;35(6):2084–92. PubMed Europe PMC Scholia" -22057392 Pubmed "Günther V, Davis AM, Georgiev O, Schaffner W. A conserved cysteine cluster, essential for transcriptional activity, mediates homodimerization of human metal-responsive transcription factor-1 (MTF-1). Biochim Biophys Acta. 2012 Feb;1823(2):476–83. PubMed Europe PMC Scholia" -22289350 Pubmed "Günther V, Lindert U, Schaffner W. The taste of heavy metals: gene regulation by MTF-1. Biochim Biophys Acta. 2012 Sep;1823(9):1416–25. PubMed Europe PMC Scholia" -23506888 Pubmed "Huang L, Tepaamorndech S. The SLC30 family of zinc transporters - a review of current understanding of their biological and pathophysiological roles. Mol Aspects Med. 2013;34(2–3):548–60. PubMed Europe PMC Scholia" -23506894 Pubmed "Jeong J, Eide DJ. The SLC39 family of zinc transporters. Mol Aspects Med. 2013;34(2–3):612–9. PubMed Europe PMC Scholia" -24416395 Pubmed "Gumulec J, Raudenska M, Adam V, Kizek R, Masarik M. Metallothionein - immunohistochemical cancer biomarker: a meta-analysis. PLoS One. 2014 Jan 8;9(1):e85346. PubMed Europe PMC Scholia" -24710731 Pubmed "Kambe T, Hashimoto A, Fujimoto S. Current understanding of ZIP and ZnT zinc transporters in human health and diseases. Cell Mol Life Sci. 2014 Sep;71(17):3281–95. PubMed Europe PMC Scholia" +10755665 Pubmed "Induction, regulation, degradation, and biological significance of mammalian metallothioneins. Miles AT, Hawksworth GM, Beattie JH, Rodilla V. Crit Rev Biochem Mol Biol. 2000;35(1):35–70. PubMed Europe PMC Scholia" +11831458 Pubmed "Cellular zinc sensors: MTF-1 regulation of gene expression. Andrews GK. Biometals. 2001;14(3–4):223–37. PubMed Europe PMC Scholia" +17344318 Pubmed "Role of GAC63 in transcriptional activation mediated by beta-catenin. Chen YH, Yang CK, Xia M, Ou CY, Stallcup MR. Nucleic Acids Res. 2007;35(6):2084–92. PubMed Europe PMC Scholia" +22057392 Pubmed "A conserved cysteine cluster, essential for transcriptional activity, mediates homodimerization of human metal-responsive transcription factor-1 (MTF-1). Günther V, Davis AM, Georgiev O, Schaffner W. Biochim Biophys Acta. 2012 Feb;1823(2):476–83. PubMed Europe PMC Scholia" +22289350 Pubmed "The taste of heavy metals: gene regulation by MTF-1. Günther V, Lindert U, Schaffner W. Biochim Biophys Acta. 2012 Sep;1823(9):1416–25. PubMed Europe PMC Scholia" +23506888 Pubmed "The SLC30 family of zinc transporters - a review of current understanding of their biological and pathophysiological roles. Huang L, Tepaamorndech S. Mol Aspects Med. 2013;34(2–3):548–60. PubMed Europe PMC Scholia" +23506894 Pubmed "The SLC39 family of zinc transporters. Jeong J, Eide DJ. Mol Aspects Med. 2013;34(2–3):612–9. PubMed Europe PMC Scholia" +24416395 Pubmed "Metallothionein - immunohistochemical cancer biomarker: a meta-analysis. Gumulec J, Raudenska M, Adam V, Kizek R, Masarik M. PLoS One. 2014 Jan 8;9(1):e85346. PubMed Europe PMC Scholia" +24710731 Pubmed "Current understanding of ZIP and ZnT zinc transporters in human health and diseases. Kambe T, Hashimoto A, Fujimoto S. Cell Mol Life Sci. 2014 Sep;71(17):3281–95. PubMed Europe PMC Scholia" diff --git a/pathways/WP3529/WP3529-datanodes.tsv b/pathways/WP3529/WP3529-datanodes.tsv index 94e25a019..020bfa3da 100644 --- a/pathways/WP3529/WP3529-datanodes.tsv +++ b/pathways/WP3529/WP3529-datanodes.tsv @@ -1,85 +1,42 @@ -Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -Zn++ Metabolite hmdb:HMDB0015532 chebi:29105;chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N -MTF1 GeneProduct ensembl:ENSG00000188786 Metal-response element-binding transcription factor-1 (MTF-1) functions as a cellular zinc sensor which coordinates the expression of genes involved in zinc homeostasis. ensembl:ENSG00000188786 ncbigene:4520 hgnc.symbol:MTF1 uniprot:Q14872 -SLC30A1 GeneProduct ncbigene:7779 Type your comment here ensembl:ENSG00000170385 ncbigene:7779 hgnc.symbol:SLC30A1 uniprot:Q9Y6M5 -SLC39A13 GeneProduct ncbigene:91252 ensembl:ENSG00000165915 ncbigene:91252 hgnc.symbol:SLC39A13 uniprot:E9PNN7;uniprot:E9PSA8;uniprot:G3V1B2;uniprot:E9PNE7;uniprot:E9PRH4;uniprot:K4DIB5;uniprot:Q96H72;uniprot:K4DIA9 -SLC39A9 GeneProduct ncbigene:55334 ensembl:ENSG00000029364 ncbigene:55334 hgnc.symbol:SLC39A9 uniprot:A0A0D9SFA2;uniprot:Q9NUM3;uniprot:M0QX28;uniprot:C4N9M8 -SLC39A10 GeneProduct ncbigene:57181 ensembl:ENSG00000196950 ncbigene:57181 hgnc.symbol:SLC39A10 uniprot:F2Z341;uniprot:E7ENT5;uniprot:A0A024R3W5;uniprot:C9J0F5;uniprot:E7EV45;uniprot:Q9ULF5 -SLC39A12 GeneProduct ncbigene:221074 ensembl:ENSG00000148482 ncbigene:221074 hgnc.symbol:SLC39A12 uniprot:Q504Y0 -SLC39A8 GeneProduct ncbigene:64116 ensembl:ENSG00000138821 ncbigene:64116 hgnc.symbol:SLC39A8 uniprot:A0A024RDG0;uniprot:Q9C0K1 -SLC39A5 GeneProduct ncbigene:283375 ensembl:ENSG00000139540 ncbigene:283375 hgnc.symbol:SLC39A5 uniprot:C9JPS5;uniprot:C9JPS6;uniprot:A0A024RB24;uniprot:C9JIB2;uniprot:C9JVC6;uniprot:Q6ZMH5;uniprot:C9JB28 -SLC39A4 GeneProduct ncbigene:55630 ensembl:ENSG00000147804 ncbigene:55630 hgnc.symbol:SLC39A4 uniprot:E9PQ16;uniprot:Q6P5W5 -SLC39A3 GeneProduct ncbigene:29985 ensembl:ENSG00000141873 ncbigene:29985 hgnc.symbol:SLC39A3 uniprot:K7EJZ1;uniprot:Q9BRY0;uniprot:F5H385;uniprot:K7ENJ1 -SLC39A2 GeneProduct ncbigene:29986 ensembl:ENSG00000165794 ncbigene:29986 hgnc.symbol:SLC39A2 uniprot:Q9NP94 -SLC39A1 GeneProduct ncbigene:27173 SLC39A1 (ZIP1) transporter is responsible for the influx of zinc into the cytoplasm ensembl:ENSG00000143570 ncbigene:27173 hgnc.symbol:SLC39A1 uniprot:Q5T4K4;uniprot:Q9NY26;uniprot:Q5T4K2;uniprot:A0A0A0MTL8 -MT1A GeneProduct ncbigene:4489 zinc is chelated by cytoplasmic proteins, such as MTs ensembl:ENSG00000205362 ncbigene:4489 hgnc.symbol:MT1A uniprot:P04731 -SLC30A1 GeneProduct ncbigene:7779 SLC30A1 (ZnT1) transporter is responsible of zinc efflux ensembl:ENSG00000170385 ncbigene:7779 hgnc.symbol:SLC30A1 uniprot:Q9Y6M5 -MT1B GeneProduct ncbigene:4490 zinc is chelated by cytoplasmic proteins, such as MTs ensembl:ENSG00000169688 ncbigene:4490 hgnc.symbol:MT1B uniprot:P07438;uniprot:H3BR34 -MT1E GeneProduct ncbigene:4493 zinc is chelated by cytoplasmic proteins, such as MTs ensembl:ENSG00000169715 ncbigene:4493 hgnc.symbol:MT1E uniprot:P04732;uniprot:H3BU80 -MT1F GeneProduct ncbigene:4494 zinc is chelated by cytoplasmic proteins, such as MTs ensembl:ENSG00000198417 ncbigene:4494 hgnc.symbol:MT1F uniprot:P04733;uniprot:H3BRY8 -MT1G GeneProduct ncbigene:4495 zinc is chelated by cytoplasmic proteins, such as MTs ensembl:ENSG00000125144 ncbigene:4495 hgnc.symbol:MT1G uniprot:H3BSF1;uniprot:P13640 -MT1H GeneProduct ncbigene:4496 zinc is chelated by cytoplasmic proteins, such as MTs ensembl:ENSG00000205358 ncbigene:4496 hgnc.symbol:MT1H uniprot:H3BTC4;uniprot:P80294;uniprot:A0A140VJP7 -MT1M GeneProduct ncbigene:4499 zinc is chelated by cytoplasmic proteins, such as MTs ensembl:ENSG00000205364 ncbigene:4499 hgnc.symbol:MT1M uniprot:Q8N339;uniprot:H3BUC6 -MT1X GeneProduct ncbigene:4501 zinc is chelated by cytoplasmic proteins, such as MTs ensembl:ENSG00000187193 ncbigene:4501 hgnc.symbol:MT1X uniprot:A0A140VJP8;uniprot:P80297;uniprot:U3KQD7 -MT2A GeneProduct ncbigene:4502 zinc is chelated by cytoplasmic proteins, such as MTs ensembl:ENSG00000125148 ncbigene:4502 hgnc.symbol:MT2A uniprot:P02795;uniprot:H3BSP9 -MT3 GeneProduct ncbigene:4504 zinc is chelated by cytoplasmic proteins, such as MTs ensembl:ENSG00000087250 ncbigene:4504 hgnc.symbol:MT3 uniprot:A0A024R6R7;uniprot:H3BPK2;uniprot:P25713;uniprot:H3BTG5;uniprot:H3BQX6 -MT1L GeneProduct ncbigene:4500 zinc is chelated by cytoplasmic proteins, such as MTs ensembl:ENSG00000260549 ncbigene:4500 hgnc.symbol:MT1L -MT4 GeneProduct ncbigene:84560 zinc is chelated by cytoplasmic proteins, such as MTs ensembl:ENSG00000102891 ncbigene:84560 hgnc.symbol:MT4 uniprot:P47944 -SLC39A7 GeneProduct ncbigene:7922 ensembl:ENSG00000112473 ncbigene:7922 hgnc.symbol:SLC39A7 uniprot:A2AAT0;uniprot:A0A024RCX7;uniprot:Q92504 -SLC39A11 GeneProduct ncbigene:201266 ensembl:ENSG00000133195 ncbigene:201266 hgnc.symbol:SLC39A11 uniprot:J3QRN3;uniprot:J3QS49;uniprot:J3KRX2;uniprot:J3QLA9;uniprot:J3QQP1;uniprot:J3KTP1;uniprot:J3KS66;uniprot:J3KRI1;uniprot:J3QLB2;uniprot:J3KT59;uniprot:Q8N1S5 -SLC39A9 GeneProduct ncbigene:55334 ensembl:ENSG00000029364 ncbigene:55334 hgnc.symbol:SLC39A9 uniprot:A0A0D9SFA2;uniprot:Q9NUM3;uniprot:M0QX28;uniprot:C4N9M8 -SLC30A9 GeneProduct ncbigene:10463 ensembl:ENSG00000014824 ncbigene:10463 hgnc.symbol:SLC30A9 uniprot:Q6PML9;uniprot:A0A0S2Z514;uniprot:D6R9M6 -SLC30A4 GeneProduct ncbigene:7782 ensembl:ENSG00000104154 ncbigene:7782 hgnc.symbol:SLC30A4 uniprot:O14863 -SLC39A8 GeneProduct ncbigene:64116 ensembl:ENSG00000138821 ncbigene:64116 hgnc.symbol:SLC39A8 uniprot:A0A024RDG0;uniprot:Q9C0K1 -SLC30A10 GeneProduct ncbigene:55532 ensembl:ENSG00000196660 ncbigene:55532 hgnc.symbol:SLC30A10 uniprot:Q6XR72 -SLC30A3 GeneProduct ncbigene:7781 ensembl:ENSG00000115194 ncbigene:7781 hgnc.symbol:SLC30A3 uniprot:Q99726;uniprot:C9JHX4;uniprot:C9JM13;uniprot:H7BZ83;uniprot:C9J1K4;uniprot:C9JV68;uniprot:C9JHZ9 -SLC30A4 GeneProduct ncbigene:7782 http://www.ncbi.nlm.nih.gov/gene/169026 ensembl:ENSG00000104154 ncbigene:7782 hgnc.symbol:SLC30A4 uniprot:O14863 -SLC30A2 GeneProduct ncbigene:7780 http://www.ncbi.nlm.nih.gov/gene/169026 ensembl:ENSG00000158014 ncbigene:7780 hgnc.symbol:SLC30A2 uniprot:Q9BRI3 -SLC39A14 GeneProduct ncbigene:23516 ensembl:ENSG00000104635 ncbigene:23516 hgnc.symbol:SLC39A14 uniprot:E5RFF5;uniprot:E5RJ40;uniprot:E5RFT1;uniprot:E5RFZ8;uniprot:A0A0S2Z534;uniprot:E5RJG5;uniprot:E5RGA7;uniprot:E5RIP4;uniprot:Q15043 -SLC30A5 GeneProduct ncbigene:64924 ensembl:ENSG00000145740 ncbigene:64924 hgnc.symbol:SLC30A5 uniprot:D6REM2;uniprot:H0Y957;uniprot:Q8TAD4;uniprot:H0YAH4 -SLC30A2 GeneProduct ncbigene:7780 ensembl:ENSG00000158014 ncbigene:7780 hgnc.symbol:SLC30A2 uniprot:Q9BRI3 -SLC30A7 GeneProduct ncbigene:148867 ensembl:ENSG00000162695 ncbigene:148867 hgnc.symbol:SLC30A7 uniprot:H0Y362;uniprot:Q8NEW0 -SLC30A4 GeneProduct ncbigene:7782 ensembl:ENSG00000104154 ncbigene:7782 hgnc.symbol:SLC30A4 uniprot:O14863 -SLC30A6 GeneProduct ncbigene:55676 ensembl:ENSG00000152683 ncbigene:55676 hgnc.symbol:SLC30A6 uniprot:C9JZR9;uniprot:Q6NXT4;uniprot:F8WCU3;uniprot:F8WEL5;uniprot:F8WD78;uniprot:B5MCR8 -SLC39A6 GeneProduct ncbigene:25800 ensembl:ENSG00000141424 ncbigene:25800 hgnc.symbol:SLC39A6 uniprot:Q13433;uniprot:K7EQ91 -SLC30A8 GeneProduct ncbigene:169026 http://www.ncbi.nlm.nih.gov/gene/169026 ensembl:ENSG00000164756 ncbigene:169026 hgnc.symbol:SLC30A8 uniprot:Q8IWU4;uniprot:E5RG87;uniprot:A0A096LNR0;uniprot:A0A096LPF3 +Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps +Zn2+ Metabolite chebi:29105 "" wikidata:Q26987394 chebi:29105 inchikey:PTFCDOFLOPIGGS-UHFFFAOYSA-N pubchem.compound:32051 chemspider:29723 hmdb:HMDB0015532 kegg.compound:C00038 +MTF1 GeneProduct ensembl:ENSG00000188786 "Metal-response element-binding transcription factor-1 (MTF-1) functions as a cellular zinc sensor which coordinates the expression of genes involved in zinc homeostasis. " ensembl:ENSG00000188786 ncbigene:4520 hgnc.symbol:MTF1 uniprot:Q14872 +SLC30A1 GeneProduct ncbigene:7779 "" ensembl:ENSG00000170385 ncbigene:7779 hgnc.symbol:SLC30A1 uniprot:Q9Y6M5 +SLC39A13 GeneProduct ncbigene:91252 "" ensembl:ENSG00000165915 ncbigene:91252 hgnc.symbol:SLC39A13 uniprot:E9PNN7;uniprot:E9PSA8;uniprot:G3V1B2;uniprot:E9PNE7;uniprot:E9PRH4;uniprot:K4DIB5;uniprot:Q96H72;uniprot:K4DIA9 +SLC39A9 GeneProduct ncbigene:55334 "" ensembl:ENSG00000029364 ncbigene:55334 hgnc.symbol:SLC39A9 uniprot:A0A0D9SFA2;uniprot:Q9NUM3;uniprot:M0QX28;uniprot:C4N9M8 +SLC39A10 GeneProduct ncbigene:57181 "" ensembl:ENSG00000196950 ncbigene:57181 hgnc.symbol:SLC39A10 uniprot:F2Z341;uniprot:E7ENT5;uniprot:A0A024R3W5;uniprot:C9J0F5;uniprot:E7EV45;uniprot:Q9ULF5 +SLC39A12 GeneProduct ncbigene:221074 "" ensembl:ENSG00000148482 ncbigene:221074 hgnc.symbol:SLC39A12 uniprot:Q504Y0 +SLC39A8 GeneProduct ncbigene:64116 "" ensembl:ENSG00000138821 ncbigene:64116 hgnc.symbol:SLC39A8 uniprot:A0A024RDG0;uniprot:A0A804HHS9;uniprot:A0A804HJR0;uniprot:Q9C0K1;uniprot:A0A804HKQ9;uniprot:A0A804HHT0;uniprot:A0A804HKW0;uniprot:A0A804HKX2 +SLC39A5 GeneProduct ncbigene:283375 "" ensembl:ENSG00000139540 ncbigene:283375 hgnc.symbol:SLC39A5 uniprot:C9JPS5;uniprot:C9JPS6;uniprot:A0A024RB24;uniprot:C9JIB2;uniprot:C9JVC6;uniprot:Q6ZMH5;uniprot:C9JB28 +SLC39A4 GeneProduct ncbigene:55630 "" ensembl:ENSG00000147804 ncbigene:55630 hgnc.symbol:SLC39A4 uniprot:E9PQ16;uniprot:Q6P5W5 +SLC39A3 GeneProduct ncbigene:29985 "" ensembl:ENSG00000141873 ncbigene:29985 hgnc.symbol:SLC39A3 uniprot:K7EJZ1;uniprot:Q9BRY0;uniprot:F5H385;uniprot:K7ENJ1 +SLC39A2 GeneProduct ncbigene:29986 "" ensembl:ENSG00000165794 ncbigene:29986 hgnc.symbol:SLC39A2 uniprot:Q9NP94 +SLC39A1 GeneProduct ncbigene:27173 "SLC39A1 (ZIP1) transporter is responsible for the influx of zinc into the cytoplasm " ensembl:ENSG00000143570 ncbigene:27173 hgnc.symbol:SLC39A1 uniprot:Q5T4K4;uniprot:Q9NY26;uniprot:Q5T4K2;uniprot:A0A0A0MTL8 +MT1A GeneProduct ncbigene:4489 "zinc is chelated by cytoplasmic proteins, such as MTs " ensembl:ENSG00000205362 ncbigene:4489 hgnc.symbol:MT1A uniprot:P04731 +SLC30A1 GeneProduct ncbigene:7779 "SLC30A1 (ZnT1) transporter is responsible of zinc efflux " ensembl:ENSG00000170385 ncbigene:7779 hgnc.symbol:SLC30A1 uniprot:Q9Y6M5 +MT1B GeneProduct ncbigene:4490 "zinc is chelated by cytoplasmic proteins, such as MTs" ensembl:ENSG00000169688 ncbigene:4490 hgnc.symbol:MT1B uniprot:P07438;uniprot:H3BR34 +MT1E GeneProduct ncbigene:4493 "zinc is chelated by cytoplasmic proteins, such as MTs" ensembl:ENSG00000169715 ncbigene:4493 hgnc.symbol:MT1E uniprot:P04732;uniprot:H3BU80 +MT1F GeneProduct ncbigene:4494 "zinc is chelated by cytoplasmic proteins, such as MTs" ensembl:ENSG00000198417 ncbigene:4494 hgnc.symbol:MT1F uniprot:P04733;uniprot:H3BRY8 +MT1G GeneProduct ncbigene:4495 "zinc is chelated by cytoplasmic proteins, such as MTs" ensembl:ENSG00000125144 ncbigene:4495 hgnc.symbol:MT1G uniprot:H3BSF1;uniprot:P13640 +MT1H GeneProduct ncbigene:4496 "zinc is chelated by cytoplasmic proteins, such as MTs" ensembl:ENSG00000205358 ncbigene:4496 hgnc.symbol:MT1H uniprot:H3BTC4;uniprot:P80294;uniprot:A0A140VJP7 +MT1M GeneProduct ncbigene:4499 "zinc is chelated by cytoplasmic proteins, such as MTs" ensembl:ENSG00000205364 ncbigene:4499 hgnc.symbol:MT1M uniprot:Q8N339;uniprot:H3BUC6 +MT1X GeneProduct ncbigene:4501 "zinc is chelated by cytoplasmic proteins, such as MTs" ensembl:ENSG00000187193 ncbigene:4501 hgnc.symbol:MT1X uniprot:A0A140VJP8;uniprot:P80297;uniprot:U3KQD7 +MT2A GeneProduct ncbigene:4502 "zinc is chelated by cytoplasmic proteins, such as MTs" ensembl:ENSG00000125148 ncbigene:4502 hgnc.symbol:MT2A uniprot:P02795;uniprot:H3BSP9 +MT3 GeneProduct ncbigene:4504 "zinc is chelated by cytoplasmic proteins, such as MTs" ensembl:ENSG00000087250 ncbigene:4504 hgnc.symbol:MT3 uniprot:A0A024R6R7;uniprot:H3BPK2;uniprot:P25713;uniprot:H3BTG5;uniprot:H3BQX6 +MT1L GeneProduct ncbigene:4500 "zinc is chelated by cytoplasmic proteins, such as MTs" +MT4 GeneProduct ncbigene:84560 "zinc is chelated by cytoplasmic proteins, such as MTs" ensembl:ENSG00000102891 ncbigene:84560 hgnc.symbol:MT4 uniprot:P47944 +SLC39A7 GeneProduct ncbigene:7922 "" ensembl:ENSG00000112473 ncbigene:7922 hgnc.symbol:SLC39A7 uniprot:A2AAT0;uniprot:A0A024RCX7;uniprot:Q92504 +SLC39A11 GeneProduct ncbigene:201266 "" ensembl:ENSG00000133195 ncbigene:201266 hgnc.symbol:SLC39A11 uniprot:J3QRN3;uniprot:J3QS49;uniprot:J3KRX2;uniprot:J3QLA9;uniprot:J3QQP1;uniprot:J3KTP1;uniprot:J3KS66;uniprot:J3KRI1;uniprot:J3QLB2;uniprot:J3KT59;uniprot:Q8N1S5 +SLC30A9 GeneProduct ncbigene:10463 "" ensembl:ENSG00000014824 ncbigene:10463 hgnc.symbol:SLC30A9 uniprot:Q6PML9;uniprot:A0A0S2Z514;uniprot:D6R9M6 +SLC30A4 GeneProduct ncbigene:7782 "" ensembl:ENSG00000104154 ncbigene:7782 hgnc.symbol:SLC30A4 uniprot:O14863 +SLC30A10 GeneProduct ncbigene:55532 "" ensembl:ENSG00000196660 ncbigene:55532 hgnc.symbol:SLC30A10 uniprot:Q6XR72 +SLC30A3 GeneProduct ncbigene:7781 "" ensembl:ENSG00000115194 ncbigene:7781 hgnc.symbol:SLC30A3 uniprot:Q99726;uniprot:C9JHX4;uniprot:C9JM13;uniprot:H7BZ83;uniprot:C9J1K4;uniprot:C9JV68;uniprot:C9JHZ9 +SLC30A4 GeneProduct ncbigene:7782 "http://www.ncbi.nlm.nih.gov/gene/169026" ensembl:ENSG00000104154 ncbigene:7782 hgnc.symbol:SLC30A4 uniprot:O14863 +SLC30A2 GeneProduct ncbigene:7780 "http://www.ncbi.nlm.nih.gov/gene/169026" ensembl:ENSG00000158014 ncbigene:7780 hgnc.symbol:SLC30A2 uniprot:Q9BRI3 +SLC39A14 GeneProduct ncbigene:23516 "" ensembl:ENSG00000104635 ncbigene:23516 hgnc.symbol:SLC39A14 uniprot:E5RFF5;uniprot:E5RJ40;uniprot:E5RFT1;uniprot:E5RFZ8;uniprot:A0A0S2Z534;uniprot:E5RJG5;uniprot:E5RGA7;uniprot:E5RIP4;uniprot:Q15043 +SLC30A5 GeneProduct ncbigene:64924 "" ensembl:ENSG00000145740 ncbigene:64924 hgnc.symbol:SLC30A5 uniprot:D6REM2;uniprot:H0Y957;uniprot:Q8TAD4;uniprot:H0YAH4 +SLC30A2 GeneProduct ncbigene:7780 "" ensembl:ENSG00000158014 ncbigene:7780 hgnc.symbol:SLC30A2 uniprot:Q9BRI3 +SLC30A7 GeneProduct ncbigene:148867 "" ensembl:ENSG00000162695 ncbigene:148867 hgnc.symbol:SLC30A7 uniprot:H0Y362;uniprot:Q8NEW0 +SLC30A6 GeneProduct ncbigene:55676 "" ensembl:ENSG00000152683 ncbigene:55676 hgnc.symbol:SLC30A6 uniprot:C9JZR9;uniprot:Q6NXT4;uniprot:F8WCU3;uniprot:F8WEL5;uniprot:F8WD78;uniprot:B5MCR8 +SLC39A6 GeneProduct ncbigene:25800 "" ensembl:ENSG00000141424 ncbigene:25800 hgnc.symbol:SLC39A6 uniprot:Q13433;uniprot:K7EQ91 +SLC30A8 GeneProduct ncbigene:169026 "http://www.ncbi.nlm.nih.gov/gene/169026" ensembl:ENSG00000164756 ncbigene:169026 hgnc.symbol:SLC30A8 uniprot:Q8IWU4;uniprot:E5RG87;uniprot:A0A096LNR0;uniprot:A0A096LPF3 diff --git a/pathways/WP3529/WP3529.gpml b/pathways/WP3529/WP3529.gpml index c63de12db..71dfed8e8 100644 --- a/pathways/WP3529/WP3529.gpml +++ b/pathways/WP3529/WP3529.gpml @@ -1,9 +1,10 @@ - + Zinc is a transition metal and catalytic cofactor involved in many biological processes such as proliferation, development and differentiation, regulation of DNA synthesis, genomic stability, cell activation, RNA transcription, immune function. Zinc homeostasis in cells is ensured by various protein families including zinc transporters, zinc-binding proteins (Metallothioneins, MTs), transcription factors (MTF1-2). ZnT (1-10) transporters are responsible of zinc efflux and are assigned to the SLC30A family while ZIP (1-14) transporters are responsible for the influx of zinc into the cytoplasm and are assigned to the SLC39A family. Zn2+ enters into the cell by the ZIP transporters, and once inside the cell is available to bind metalloproteins (MT) which deliver to ZnT, or the zinc can bind to directly ZnTs and then deliver in the organelles / vesicles or lead outside the cell. Elevated zinc levels have been reported in different tumour tissue, such as breast and lung cancer - Metal-response element-binding transcription factor-1 (MTF-1) functions as a cellular zinc sensor which coordinates the expression of genes involved in zinc homeostasis. + Metal-response element-binding transcription factor-1 (MTF-1) functions as a cellular zinc sensor which coordinates the expression of genes involved in zinc homeostasis. + b85 c8b b6b @@ -11,7 +12,6 @@ - Type your comment here @@ -52,17 +52,18 @@ - SLC39A1 (ZIP1) transporter is responsible for the influx of zinc into the cytoplasm + SLC39A1 (ZIP1) transporter is responsible for the influx of zinc into the cytoplasm + - zinc is chelated by cytoplasmic proteins, such as MTs + zinc is chelated by cytoplasmic proteins, such as MTs - SLC30A1 (ZnT1) transporter is responsible of zinc efflux + SLC30A1 (ZnT1) transporter is responsible of zinc efflux @@ -168,177 +169,177 @@ - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + @@ -363,348 +364,348 @@ - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - + diff --git a/pathways/WP3529/WP3529.json b/pathways/WP3529/WP3529.json index 327460c40..60a1bd65f 100644 --- a/pathways/WP3529/WP3529.json +++ b/pathways/WP3529/WP3529.json @@ -15,7 +15,7 @@ "gpmlElementName": "DataNode", "height": 19.35734925594997, "id": "a07a6", - "isPartOf": "a7225", + "isPartOf": "dc8ab", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -66,7 +66,7 @@ "stroke": "#ff6600", "strokeWidth": 0, "textAlign": "center", - 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immunohistochemical cancer biomarker: a meta-analysis.", - "textContent": "8", + "textContent": "10", + "type": [ + "PublicationXref", + "PubMed:24416395" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "24416395", + "year": 2014 + }, + "publicationXrefd55": { + "authors": [ + "Miles AT", + "Hawksworth GM", + "Beattie JH", + "Rodilla V." + ], + "gpmlElementName": "PublicationXref", + "id": "publicationXrefd55", + "source": "Crit Rev Biochem Mol Biol. 2000;35(1):35-70.", + "standardName": "Induction, regulation, degradation, and biological significance of mammalian metallothioneins", + "textContent": "1", + "type": [ + "PublicationXref", + "PubMed:10755665" + ], + "xrefDataSource": "PubMed", + "xrefIdentifier": "10755665", + "year": 2000 + }, + "publicationXrefe00": { + "authors": [ + "Gumulec J", + "Raudenska M", + "Adam V, Kizek R", + "Masarik M." + ], + "gpmlElementName": "PublicationXref", + "id": "publicationXrefe00", + "source": "PLoS One. 2014 Jan 8;9(1):e85346", + "standardName": "Metallothionein - immunohistochemical cancer biomarker: a meta-analysis.", + "textContent": "11", "type": [ "PublicationXref", "PubMed:24416395" @@ -8538,7 +8657,7 @@ "id": "publicationXrefeaf", "source": "Crit Rev Biochem Mol Biol", "standardName": "Induction, regulation, degradation, and biological significance of mammalian metallothioneins.", - "textContent": "1", + "textContent": "2", "type": [ "PublicationXref", "PubMed:10755665" @@ -8574,7 +8693,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXreffcd", "standardName": "The SLC30 family of zinc transporters - a review of current understanding of their biological and pathophysiological roles", - "textContent": "6", + "textContent": "8", "type": [ "PublicationXref", "PubMed:23506888" @@ -8582,16 +8701,41 @@ "xrefDataSource": "PubMed", "xrefIdentifier": "23506888", "year": 2013 + }, + "pvjsgeneratedidff4c7": { + "attachmentDisplay": { + "offset": [ + 0, + 0 + ], + "position": [ + 0.4, + 0 + ] + }, + "drawAs": "rect", + "gpmlElementName": "Anchor", + "height": 4, + "id": "pvjsgeneratedidff4c7", + "isAttachedTo": "b6e2b", + "kaavioType": "Burr", + "strokeWidth": 0, + "type": [ + "Anchor", + "Burr" + ], + "width": 4, + "zIndex": -33 } }, "pathway": { "@context": [ "https://cdn.rawgit.com/wikipathways/WpVocabularies/7a46a05/contexts/pvjs.jsonld", { - "@base": "http://identifiers.org/wikipathways/WP3529/" + "@base": "WP3529/" } ], - "author": "[GIOVANNA VALENTI, Trovato angela, Egonw, Khanspers, Mkutmon, MaintBot]", + "author": "[GIOVANNA VALENTI, Trovato angela, Egonw, Khanspers, Mkutmon, MaintBot, Eweitz]", "comments": [ { "content": "Zinc is a transition metal and catalytic cofactor involved in many biological processes such as proliferation, development and differentiation, regulation of DNA synthesis, genomic stability, cell activation, RNA transcription, immune function. Zinc homeostasis in cells is ensured by various protein families including zinc transporters, zinc-binding proteins (Metallothioneins, MTs), transcription factors (MTF1-2). ZnT (1-10) transporters are responsible of zinc efflux and are assigned to the SLC30A family while ZIP (1-14) transporters are responsible for the influx of zinc into the cytoplasm and are assigned to the SLC39A family. Zn2+ enters into the cell by the ZIP transporters, and once inside the cell is available to bind metalloproteins (MT) which deliver to ZnT, or the zinc can bind to directly ZnTs and then deliver in the organelles / vesicles or lead outside the cell. Elevated zinc levels have been reported in different tumour tissue, such as breast and lung cancer", @@ -8655,9 +8799,9 @@ "a6dcf", "cce29", "dd962", - "cbbdb", + "b6821", "fc590", - "a7225", + "dc8ab", "e6a6d", "fe371", "e1379", @@ -8744,7 +8888,7 @@ "fcbda", "c6d04" ], - "dataSourceVersion": "WP3529_r120882", + "dataSourceVersion": "WP3529_r134280", "displayName": "Zinc homeostasis", "drawAs": "rect", "fill": "white", @@ -8752,9 +8896,9 @@ "fontWeight": "bold", "gpmlElementName": "Pathway", "height": 883.5471375000003, - "id": "http://identifiers.org/wikipathways/WP3529", + "id": "WP3529", "kaavioType": "Group", - "lastModified": "20220127155617", + "lastModified": "20240719113743", "name": "Zinc homeostasis", "organism": "Homo sapiens", "padding": 5, @@ -8763,7 +8907,7 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Zinc homeostasis\nLast Modified: 20220127155617\nOrganism: Homo sapiens", + "textContent": "Name: Zinc homeostasis\nLast Modified: 20240719113743\nOrganism: Homo sapiens", "type": [ "Pathway", "http://identifiers.org/pw/PW:0000355" diff --git a/pathways/WP3529/WP3529.png b/pathways/WP3529/WP3529.png index 45999693b..671467e3e 100644 Binary files a/pathways/WP3529/WP3529.png and b/pathways/WP3529/WP3529.png differ diff --git a/pathways/WP3529/WP3529.svg b/pathways/WP3529/WP3529.svg index 1fe600346..d5a5b5af6 100644 --- a/pathways/WP3529/WP3529.svg +++ b/pathways/WP3529/WP3529.svg @@ -1,5 +1,5 @@ - + @@ -508,8 +508,8 @@ - - + + @@ -788,8 +788,8 @@ SLC39A13 - - + + @@ -808,7 +808,7 @@ SLC39A12 - + SLC39A8 @@ -865,8 +865,8 @@ - - + + @@ -927,7 +927,7 @@ MT3 - + MT1L @@ -963,8 +963,8 @@ - - + + @@ -1031,7 +1031,7 @@ SLC30A4 - + SLC39A8 @@ -1058,8 +1058,8 @@ - - + + @@ -1107,46 +1107,46 @@ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Early Endosomes + Early endosomes - + - Endosomes / Lysosomes + Endosomes / lysosomes @@ -1156,10 +1156,10 @@ (pancreatic beta cells) - + - Vesicles secretory + Secretory vesicles (mammary epithelial cells) @@ -1169,58 +1169,58 @@ MTs - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ @@ -1228,22 +1228,22 @@ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ @@ -1257,16 +1257,16 @@ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ @@ -1274,16 +1274,16 @@ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ @@ -1291,118 +1291,118 @@ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ - + - Zn++ + Zn2+ @@ -1416,10 +1416,10 @@ SLC30A2 - + - Zn++ + Zn2+ @@ -1451,9 +1451,9 @@ SLC30A8 - + Name: Zinc homeostasis - Last Modified: 20220127155617 + Last Modified: 20240719113743 Organism: Homo sapiens diff --git a/pathways/WP3622/WP3622-bibliography.tsv b/pathways/WP3622/WP3622-bibliography.tsv index d8a6f2c4c..959c49702 100644 --- a/pathways/WP3622/WP3622-bibliography.tsv +++ b/pathways/WP3622/WP3622-bibliography.tsv @@ -1,4 +1,4 @@ ID Database Citation -23473981 Pubmed "Saito K, Yonekura-Sakakibara K, Nakabayashi R, Higashi Y, Yamazaki M, Tohge T, et al. The flavonoid biosynthetic pathway in Arabidopsis: structural and genetic diversity. Plant Physiol Biochem. 2013 Nov;72:21–34. PubMed Europe PMC Scholia" -23577015 Pubmed "Fukushima A, Kusano M. Recent progress in the development of metabolome databases for plant systems biology. Front Plant Sci. 2013 Apr 4;4:73. PubMed Europe PMC Scholia" -25342293 Pubmed "Sumner LW, Lei Z, Nikolau BJ, Saito K. Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects. Nat Prod Rep. 2015 Feb;32(2):212–29. PubMed Europe PMC Scholia" +23473981 Pubmed "The flavonoid biosynthetic pathway in Arabidopsis: structural and genetic diversity. Saito K, Yonekura-Sakakibara K, Nakabayashi R, Higashi Y, Yamazaki M, Tohge T, et al. Plant Physiol Biochem. 2013 Nov;72:21–34. PubMed Europe PMC Scholia" +23577015 Pubmed "Recent progress in the development of metabolome databases for plant systems biology. Fukushima A, Kusano M. Front Plant Sci. 2013 Apr 4;4:73. PubMed Europe PMC Scholia" +25342293 Pubmed "Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects. Sumner LW, Lei Z, Nikolau BJ, Saito K. Nat Prod Rep. 2015 Feb;32(2):212–29. PubMed Europe PMC Scholia" diff --git a/pathways/WP3622/WP3622-datanodes.tsv b/pathways/WP3622/WP3622-datanodes.tsv index ea8563949..779b7ec02 100644 --- a/pathways/WP3622/WP3622-datanodes.tsv +++ b/pathways/WP3622/WP3622-datanodes.tsv @@ -1,154 +1,154 @@ -Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI -Lactic acid Metabolite hmdb:HMDB0000190 chebi:422;chebi:422 inchikey:JVTAAEKCZFNVCJ-REOHCLBHSA-N -Glycerol 3-phosphate Metabolite hmdb:HMDB0000126 chebi:15978;chebi:15978 inchikey:AWUCVROLDVIAJX-GSVOUGTGSA-N -GABA Metabolite hmdb:HMDB0000112 chebi:16865;chebi:16865 inchikey:BTCSSZJGUNDROE-UHFFFAOYSA-N -Cystine Metabolite hmdb:HMDB0000192 chebi:16283;chebi:16283 inchikey:LEVWYRKDKASIDU-IMJSIDKUSA-N -Dihydrouracil Metabolite hmdb:HMDB0000076 chebi:15901;chebi:15901 inchikey:OIVLITBTBDPEFK-UHFFFAOYSA-N -Pyruvic acid Metabolite hmdb:HMDB0000243 chebi:32816;chebi:32816 inchikey:LCTONWCANYUPML-UHFFFAOYSA-N -Leucine Metabolite hmdb:HMDB0000687 chebi:15603;chebi:15603 inchikey:ROHFNLRQFUQHCH-YFKPBYRVSA-N -Galactinol Metabolite hmdb:HMDB0005826 chebi:17505;chebi:17505 inchikey:VCWMRQDBPZKXKG-DXNLKLAMSA-N -Glucose Metabolite hmdb:HMDB0000122 chebi:15903;chebi:15903 inchikey:WQZGKKKJIJFFOK-VFUOTHLCSA-N -Xylose Metabolite hmdb:HMDB0000098 chebi:53455;chebi:53455 inchikey:SRBFZHDQGSBBOR-IOVATXLUSA-N -Threonine Metabolite hmdb:HMDB0000167 chebi:16857;chebi:16857 inchikey:AYFVYJQAPQTCCC-GBXIJSLDSA-N -Glutamic acid Metabolite hmdb:HMDB0000148 chebi:16015;chebi:16015 inchikey:WHUUTDBJXJRKMK-VKHMYHEASA-N -Nicotinic acid Metabolite hmdb:HMDB0001488 chebi:15940;chebi:15940 inchikey:PVNIIMVLHYAWGP-UHFFFAOYSA-N -Threonic acid Metabolite hmdb:HMDB0000943 chebi:15908;chebi:15908 inchikey:JPIJQSOTBSSVTP-STHAYSLISA-N -Mannose Metabolite hmdb:HMDB0000169 chebi:28729;chebi:28729 inchikey:WQZGKKKJIJFFOK-PQMKYFCFSA-N -Fructose 1,6-bisphosphate Metabolite hmdb:HMDB0001058 chebi:28013;chebi:28013 inchikey:RNBGYGVWRKECFJ-ARQDHWQXSA-N -Glyceric acid Metabolite hmdb:HMDB0000139 chebi:32398;chebi:32398 inchikey:RBNPOMFGQQGHHO-UWTATZPHSA-N -Serine Metabolite hmdb:HMDB0000187 chebi:17115;chebi:17115 inchikey:MTCFGRXMJLQNBG-REOHCLBHSA-N -Glucose-6-phosphate Metabolite hmdb:HMDB0001401 chebi:4170;chebi:4170 inchikey:NBSCHQHZLSJFNQ-GASJEMHNSA-N -Myo-inositol 1-phosphate Metabolite hmdb:HMDB0000213 chebi:18297;chebi:18297 inchikey:INAPMGSXUVUWAF-UOTPTPDRSA-N -Campesterol Metabolite hmdb:HMDB0002869 chebi:28623;chebi:28623 inchikey:SGNBVLSWZMBQTH-PODYLUTMSA-N -Sucrose Metabolite kegg.compound:C00089 wikidata:Q4027534 chebi:17992;chebi:17992 inchikey:CZMRCDWAGMRECN-UGDNZRGBSA-N -Ascorbic acid Metabolite hmdb:HMDB0000044 chebi:29073;chebi:29073 inchikey:CIWBSHSKHKDKBQ-JLAZNSOCSA-N -Homocysteine Metabolite hmdb:HMDB0000742 chebi:17588;chebi:17588 inchikey:FFFHZYDWPBMWHY-VKHMYHEASA-N -Glycine Metabolite hmdb:HMDB0000123 chebi:15428;chebi:15428 inchikey:DHMQDGOQFOQNFH-UHFFFAOYSA-N -Glycerol 2-phosphate Metabolite kegg.compound:C02979 wikidata:Q21099098 chebi:17270;chebi:17270 inchikey:DHCLVCXQIBBOPH-UHFFFAOYSA-N -Fructose Metabolite hmdb:HMDB0000660 chebi:28645;chebi:28645 inchikey:RFSUNEUAIZKAJO-ARQDHWQXSA-N -Homoserine Metabolite hmdb:HMDB0000719 chebi:15699;chebi:15699 inchikey:UKAUYVFTDYCKQA-VKHMYHEASA-N -Phytol Metabolite hmdb:HMDB0002019 chebi:17327;chebi:17327 inchikey:BOTWFXYSPFMFNR-PYDDKJGSSA-N -Cysteine Metabolite hmdb:HMDB0000574 chebi:17561;chebi:17561 inchikey:XUJNEKJLAYXESH-REOHCLBHSA-N -3-Phosphoglyceric acid Metabolite hmdb:HMDB0000807 chebi:17050;chebi:17050 inchikey:OSJPPGNTCRNQQC-UHFFFAOYSA-N -Beta-Sitosterol Metabolite hmdb:HMDB0000852 chebi:27693;chebi:27693 inchikey:KZJWDPNRJALLNS-VJSFXXLFSA-N -Alanine Metabolite hmdb:HMDB0000161 chebi:16977;chebi:16977 inchikey:QNAYBMKLOCPYGJ-REOHCLBHSA-N -Rhamnose Metabolite hmdb:HMDB0000849 chebi:62346;chebi:62346 inchikey:SHZGCJCMOBCMKK-JFNONXLTSA-N -Maltose Metabolite hmdb:HMDB0000163 chebi:47937;chebi:47937 inchikey:GUBGYTABKSRVRQ-DKBJLJRDSA-N -Phosphoenolpyruvic acid Metabolite hmdb:HMDB0000263 chebi:44897;chebi:44897 inchikey:DTBNBXWJWCWCIK-UHFFFAOYSA-N -Succinyl-CoA Metabolite hmdb:HMDB0001022 chebi:15380;chebi:15380 inchikey:VNOYUJKHFWYWIR-ITIYDSSPSA-N -Isorhamnetin Metabolite hmdb:HMDB0002655 chebi:6052;chebi:6052 inchikey:IZQSVPBOUDKVDZ-UHFFFAOYSA-N -Acetyl-CoA Metabolite hmdb:HMDB0001206 chebi:15351;chebi:15351 inchikey:ZSLZBFCDCINBPY-ZSJPKINUSA-N -Dehydroascorbic acid Metabolite hmdb:HMDB0001264 chebi:27956;chebi:27956 inchikey:SBJKKFFYIZUCET-JLAZNSOCSA-N -Oxaloacetic acid Metabolite hmdb:HMDB0000223 chebi:30744;chebi:30744 inchikey:KHPXUQMNIQBQEV-UHFFFAOYSA-N -Myoinositol Metabolite hmdb:HMDB0000211 chebi:17268;chebi:17268 inchikey:CDAISMWEOUEBRE-GPIVLXJGSA-N -Fructose-6-phosphate Metabolite hmdb:HMDB0000124 chebi:15946;chebi:15946 inchikey:GSXOAOHZAIYLCY-HSUXUTPPSA-N -Raffinose Metabolite hmdb:HMDB0003213 chebi:16634;chebi:16634 inchikey:MUPFEKGTMRGPLJ-ZQSKZDJDSA-N -Nicotianamine Metabolite kegg.compound:C05324 wikidata:Q11324211 chebi:17721;chebi:17721 inchikey:KRGPXXHMOXVMMM-CIUDSAMLSA-N -Galacturonic acid Metabolite hmdb:HMDB0002545 chebi:47962;chebi:47962 inchikey:IAJILQKETJEXLJ-RSJOWCBRSA-N -Arabinose Metabolite hmdb:HMDB0029942 chebi:46996;chebi:46996 inchikey:SRBFZHDQGSBBOR-SQOUGZDYSA-N -Ribose Metabolite hmdb:HMDB0000283 chebi:47013;chebi:47013 inchikey:HMFHBZSHGGEWLO-SOOFDHNKSA-N -Trehalose Metabolite hmdb:HMDB0000975 chebi:16551;chebi:16551 inchikey:HDTRYLNUVZCQOY-LIZSDCNHSA-N -Lysine Metabolite hmdb:HMDB0000182 chebi:18019;chebi:18019 inchikey:KDXKERNSBIXSRK-YFKPBYRVSA-N -Aspartic acid Metabolite hmdb:HMDB0000191 chebi:17053;chebi:17053 inchikey:CKLJMWTZIZZHCS-REOHCLBHSA-N -Beta-Alanine Metabolite hmdb:HMDB0000056 chebi:16958;chebi:16958 inchikey:UCMIRNVEIXFBKS-UHFFFAOYSA-N -Valine Metabolite hmdb:HMDB0000883 chebi:16414;chebi:16414 inchikey:KZSNJWFQEVHDMF-BYPYZUCNSA-N -Uracil Metabolite hmdb:HMDB0000300 chebi:17568;chebi:17568 inchikey:ISAKRJDGNUQOIC-UHFFFAOYSA-N -Isoleucine Metabolite hmdb:HMDB0000172 chebi:17191;chebi:17191 inchikey:AGPKZVBTJJNPAG-WHFBIAKZSA-N -Asparagine Metabolite hmdb:HMDB0000168 chebi:17196;chebi:17196 inchikey:DCXYFEDJOCDNAF-REOHCLBHSA-N -Citric acid Metabolite hmdb:HMDB0000094 chebi:30769;chebi:30769 inchikey:KRKNYBCHXYNGOX-UHFFFAOYSA-N -Isocitric acid Metabolite hmdb:HMDB0000193 chebi:30887;chebi:30887 inchikey:ODBLHEXUDAPZAU-UHFFFAOYSA-N -cis-Aconitic acid Metabolite hmdb:HMDB0000072 chebi:32805;chebi:32805 inchikey:GTZCVFVGUGFEME-IWQZZHSRSA-N -2-Oxo-glutaric acid Metabolite hmdb:HMDB0000208 chebi:30915;chebi:30915 inchikey:KPGXRSRHYNQIFN-UHFFFAOYSA-N -Succinic acid Metabolite hmdb:HMDB0000254 chebi:15741;chebi:15741 inchikey:KDYFGRWQOYBRFD-UHFFFAOYSA-N -Fumaric acid Metabolite hmdb:HMDB0000134 chebi:18012;chebi:18012 inchikey:VZCYOOQTPOCHFL-OWOJBTEDSA-N -Malic acid Metabolite hmdb:HMDB0000744 -Methionine Metabolite hmdb:HMDB0000696 chebi:16643;chebi:16643 inchikey:FFEARJCKVFRZRR-BYPYZUCNSA-N -S-Adenosylmethionine Metabolite hmdb:HMDB0001185 chebi:15414;chebi:15414 inchikey:MEFKEPWMEQBLKI-AIRLBKTGSA-O -Arginine Metabolite hmdb:HMDB0000517 chebi:16467;chebi:16467 inchikey:ODKSFYDXXFIFQN-BYPYZUCNSA-N -Glutamine Metabolite hmdb:HMDB0000641 chebi:18050;chebi:18050 inchikey:ZDXPYRJPNDTMRX-VKHMYHEASA-N -Histidine Metabolite hmdb:HMDB0000177 chebi:15971;chebi:15971 inchikey:HNDVDQJCIGZPNO-YFKPBYRVSA-N -Proline Metabolite hmdb:HMDB0000162 chebi:17203;chebi:17203 inchikey:ONIBWKKTOPOVIA-BYPYZUCNSA-N -Ornithine Metabolite hmdb:HMDB0000214 chebi:15729;chebi:15729 inchikey:AHLPHDHHMVZTML-BYPYZUCNSA-N -Hydroxylamine Metabolite hmdb:HMDB0003338 chebi:15429;chebi:15429 inchikey:AVXURJPOCDRRFD-UHFFFAOYSA-N -Putrescine Metabolite hmdb:HMDB0001414 chebi:17148;chebi:17148 inchikey:KIDHWZJUCRJVML-UHFFFAOYSA-N -Spermidine Metabolite hmdb:HMDB0001257 chebi:16610;chebi:16610 inchikey:ATHGHQPFGPMSJY-UHFFFAOYSA-N -Ethanolamine Metabolite hmdb:HMDB0000149 chebi:16000;chebi:16000 inchikey:HZAXFHJVJLSVMW-UHFFFAOYSA-N -F1 Metabolite kegg.compound:C16981 wikidata:Q6345965 chebi:68883;chebi:68883 inchikey:PUPKKEQDLNREIM-QNSQPKOQSA-N -Shikimic acid Metabolite hmdb:HMDB0003070 chebi:16119;chebi:16119 inchikey:JXOHGGNKMLTUBP-HSUXUTPPSA-N -Quinic acid Metabolite hmdb:HMDB0003072 chebi:17521;chebi:17521 inchikey:AAWZDTNXLSGCEK-WYWMIBKRSA-N -Phenylalanine Metabolite hmdb:HMDB0000159 chebi:17295;chebi:17295 inchikey:COLNVLDHVKWLRT-QMMMGPOBSA-N -F2 Metabolite knapsack:C00005184 wikidata:Q23058972 inchikey:JYXSWDCPHRTYGU-KSAWAZCGSA-N -Tryptophan Metabolite hmdb:HMDB0000929 chebi:16828;chebi:16828 inchikey:QIVBCDIJIAJPQS-VIFPVBQESA-N -Tyrosine Metabolite hmdb:HMDB0000158 chebi:17895;chebi:17895 inchikey:OUYCCCASQSFEME-QMMMGPOBSA-N -F5 Metabolite knapsack:C00005432 wikidata:Q23418551 chebi:133245 inchikey:GXLQUHPXGLZNGE-BRHFUIPOSA-N -F6 Metabolite knapsack:C00005428 wikidata:Q56236938 inchikey:OTUCXMIQUNROBJ-FVQHZYONNA-N -F3 Metabolite knapsack:C00005237 wikidata:Q23417468 inchikey:DDELFAUOHDSZJL-JEHSZLPQSA-N -F4 Metabolite knapsack:C00005234 wikidata:Q23417271 chebi:133218;chebi:133218 inchikey:QFSDWLPMRWDFID-CSNYLUTCSA-N -Tryptamine Metabolite hmdb:HMDB0000303 chebi:16765;chebi:16765 inchikey:APJYDQYYACXCRM-UHFFFAOYSA-N -Triethanolamine Metabolite hmdb:HMDB0032538 chebi:28621;chebi:28621 inchikey:GSEJCLTVZPLZKY-UHFFFAOYSA-N -Benzoic acid Metabolite hmdb:HMDB0001870 chebi:30746;chebi:30746 inchikey:WPYMKLBDIGXBTP-UHFFFAOYSA-N -Caffeic acid Metabolite hmdb:HMDB0001964 chebi:16433;chebi:16433 inchikey:QAIPRVGONGVQAS-DUXPYHPUSA-N -Alpha-Tocopherol Metabolite hmdb:HMDB0001893 chebi:18145;chebi:18145 inchikey:GVJHHUAWPYXKBD-IEOSBIPESA-N -Tyramine Metabolite hmdb:HMDB0000306 chebi:15760;chebi:15760 inchikey:DZGWFCGJZKJUFP-UHFFFAOYSA-N -A1 Metabolite kegg.compound:C20493 Cyanidin 3-sambubioside-5-glucoside
Type your comment here wikidata:Q23419061 inchikey:OLBLWNPOURNBCY-QFEPKXLGSA-O -A2 Metabolite knapsack:C00007655 wikidata:Q23449332 inchikey:CVAUKYVPQCYVDV-IPDRLXFSSA-O -A5 Metabolite knapsack:C00007657 wikidata:Q23464928 inchikey:JKGXHHXZZLNEGD-XUYFGVRGSA-O -A6 Metabolite knapsack:C00007658 wikidata:Q23462761 inchikey:OPWPCWHMCUWCGG-VTRYSJNRSA-O -A3 Metabolite knapsack:C00006836 wikidata:Q23419072 inchikey:JSYDBTWJIIAZPU-OMLFMJQWSA-O -A4 Metabolite knapsack:C00007656 wikidata:Q23464998 inchikey:HKRACDHMWOGFKJ-BPVIEZTISA-O -A7 Metabolite knapsack:C00007660 wikidata:Q23462624 inchikey:ABJDYMVXHLYTHZ-DULZENQLSA-O -A8 Metabolite knapsack:C00007659 wikidata:Q23462702 inchikey:NXTHTMNXJOEVLR-JHBYNAJCSA-O -A11 Metabolite knapsack:C00007570 wikidata:Q23449331 inchikey:QRNIDVBVORPNBX-WSXZECFZSA-O -A9 Metabolite knapsack:C00006838 wikidata:Q23419083 inchikey:MAKMINQMKSULBY-HHNMOXDYSA-O -A10 Metabolite knapsack:C00007661 wikidata:Q23462550 inchikey:QPUCGPFRKWVURQ-SLWMWEMUSA-O -F7 Metabolite kegg.compound:C19796 wikidata:Q23418549 chebi:133244;chebi:133244 inchikey:MCTZMXCUYPDYNE-AHHFARBASA-N -F8 Metabolite knapsack:C00005470 wikidata:Q23418553 inchikey:WLPJMCCYDZFCBL-JJSAVOBRSA-N -F14 Metabolite knapsack:C00005557 wikidata:Q45410367 inchikey:NEJKEXUJCSYMCC-AKTJOMHVSA-N -F15 Metabolite knapsack:C00005558 wikidata:Q23049771 inchikey:UWQOGHWNWIJMNI-SZBCTZJWSA-N -F19 Metabolite knapsack:C00005174 wikidata:Q23058968 inchikey:JIGYKOJSDSJFFW-DBFSWMNWSA-N -F23 Metabolite knapsack:C00005368 wikidata:Q23417673 inchikey:PZZRDJXEMZMZFD-SQIUQIIDSA-N -F20 Metabolite knapsack:C00005188 wikidata:Q23048396 inchikey:MBLYALXOUBKFNE-NAYQWVCRSA-N -F24 Metabolite kegg.compound:C01750 wikidata:Q1649777 chebi:17558;chebi:17558 inchikey:OXGUCUVFOIWWQJ-HQBVPOQASA-N -F27 Metabolite knapsack:C00005526 wikidata:Q23049767 inchikey:UXXAEVMOIUAYQT-KEXGRDQZSA-N -F28 Metabolite knapsack:C00005525 wikidata:Q23049780 inchikey:CQLRUIIRRZYHHS-BYXQHVMRSA-N -F29 Metabolite knapsack:C00005551 wikidata:Q23049759 inchikey:UIXIEXAWTSBGCB-PLZSGXCYSA-N -F30 Metabolite knapsack:C00005559 wikidata:Q23049774 inchikey:UNMZJSVCTCKOEC-QPPFPMOSSA-N -Quercetin Metabolite hmdb:HMDB0005794 chebi:16243;chebi:16243 inchikey:REFJWTPEDVJJIY-UHFFFAOYSA-N -Kaempferol Metabolite hmdb:HMDB0005801 chebi:28499;chebi:28499 inchikey:IYRMWMYZSQPJKC-UHFFFAOYSA-N -Cyanidin Metabolite chebi:27843 wikidata:Q417606 chebi:27843;chebi:27843 inchikey:VEVZSMAEJFVWIL-UHFFFAOYSA-O -Gluconic acid Metabolite hmdb:HMDB0000625 chebi:33198;chebi:33198 inchikey:RGHNJXZEOKUKBD-SQOUGZDYSA-N -Glutathione Metabolite hmdb:HMDB0000125 chebi:16856;chebi:16856 inchikey:RWSXRVCMGQZWBV-WDSKDSINSA-N -glycerate 3-phosphate Metabolite hmdb:HMDB0000807 chebi:17050;chebi:17050 inchikey:OSJPPGNTCRNQQC-UHFFFAOYSA-N -C14:0 Metabolite hmdb:HMDB0000806 chebi:28875;chebi:28875 inchikey:TUNFSRHWOTWDNC-UHFFFAOYSA-N -C16:0 Metabolite hmdb:HMDB0000220 chebi:15756;chebi:15756 inchikey:IPCSVZSSVZVIGE-UHFFFAOYSA-N -C18:0 Metabolite hmdb:HMDB0000827 chebi:28842;chebi:28842 inchikey:QIQXTHQIDYTFRH-UHFFFAOYSA-N -C18:2 Metabolite hmdb:HMDB0000673 chebi:17351;chebi:17351 inchikey:OYHQOLUKZRVURQ-HZJYTTRNSA-N -C18:3 Metabolite hmdb:HMDB0001388 chebi:27432;chebi:27432 inchikey:DTOSIQBPPRVQHS-PDBXOOCHSA-N -C24:0 Metabolite hmdb:HMDB0002003 chebi:28866;chebi:28866 inchikey:QZZGJDVWLFXDLK-UHFFFAOYSA-N -Cholesterol Metabolite hmdb:HMDB0000067 chebi:16113;chebi:16113 inchikey:HVYWMOMLDIMFJA-DPAQBDIFSA-N -Stigmasterol Metabolite hmdb:HMDB0000937 chebi:28824;chebi:28824 inchikey:HCXVJBMSMIARIN-PHZDYDNGSA-N -Glutaric acid Metabolite hmdb:HMDB0000661 chebi:17859;chebi:17859 inchikey:JFCQEDHGNNZCLN-UHFFFAOYSA-N -Salicylic acid Metabolite hmdb:HMDB0001895 chebi:16914;chebi:16914 inchikey:YGSDEFSMJLZEOE-UHFFFAOYSA-N -3-MTP Metabolite kegg.compound:C08412 wikidata:Q27106759 chebi:5407;chebi:79326;chebi:5407 inchikey:ZCZCVJVUJGULMO-IIPHORNXSA-M -3-MSOP Metabolite kegg.compound:C08405 wikidata:Q27106752 chebi:5400;chebi:5400 inchikey:OFKKQTQFWWIRBD-ZHVGPZTNSA-M -4-MSOB Metabolite kegg.compound:C08410 wikidata:Q27106757 chebi:5405;chebi:5405 inchikey:WJMGSLJQEIYHOF-URYVQPGZSA-M -4-MTB Metabolite kegg.compound:C08409 wikidata:Q27106756 chebi:79325;chebi:79325;chebi:5404;chebi:5404 inchikey:GKUMMDFLKGFCKH-AHMUMSBHSA-N;inchikey:GKUMMDFLKGFCKH-AHMUMSBHSA-M -5-MTP Metabolite kegg.compound:C08401 wikidata:Q27106749 chebi:5396;chebi:5396;chebi:79324 inchikey:MEFPHTVXBPLRLX-CBEPRAPJSA-M;inchikey:MEFPHTVXBPLRLX-ZMHPAJMFSA-N -5-MSOP Metabolite kegg.compound:C08400 wikidata:Q27106748 chebi:5395;chebi:5395 inchikey:HUCGRJSHMZWRQQ-PWGYDFSISA-N -6-MTH Metabolite knapsack:C00007844 wikidata:Q27154956 chebi:80987;chebi:80987 inchikey:ZAKICGFSIJSCSF-LPUQOGTASA-N -6-MSOH Metabolite knapsack:C00007348 wikidata:Q59571080 chebi:136956;chebi:136956 inchikey:OOGAQHVYHLPICD-DNDZILKHSA-N -7-MTH Metabolite knapsack:C00007353 wikidata:Q27154957 chebi:80988;chebi:80988 inchikey:SJHVRBSHKTUXLG-LFHLZQBKSA-N -7-MSOH Metabolite knapsack:C00007352 wikidata:Q59571113 chebi:132553;chebi:132553 inchikey:LQZALQLZOQQFGM-MMLSCURJSA-N -8-MTO Metabolite knapsack:C00007356 wikidata:Q27154958 chebi:80989;chebi:80989 inchikey:CWOJBEDMJKZKAB-JZYAIQKZSA-N -8-MSOO Metabolite knapsack:C00007355 wikidata:Q27154960 chebi:80998;chebi:80998 inchikey:GPMDJOOLATZDQL-OTNWBXTQSA-N -PA Metabolite kegg.compound:C00416 wikidata:Q66000256 chebi:16337;chebi:16337 -DAG Metabolite kegg.compound:C00165 wikidata:Q161466 chebi:18035;chebi:18035 -MGDG Metabolite chemspider:4696840 wikidata:Q42403321 chebi:169499 inchikey:QUZHZFAQJATMCA-NYFMCUGMSA-N -DGDG Metabolite chemspider:28495919 wikidata:Q42403316 chebi:136795;chebi:136795 inchikey:KDYAPQVYJXUQNY-OPHDRXFHSA-N -SQDG Metabolite chemspider:140119 wikidata:Q42403295 inchikey:RVUUQPKXGDTQPG-PINKXYAGSA-N -PC Metabolite chemspider:4946694 wikidata:Q42403329 inchikey:XXKFQTJOJZELMD-RSLAUBRISA-N -PE Metabolite chemspider:7825685 wikidata:Q42403336 inchikey:WIHSZOXPODIZSW-YTWBPVBXSA-N -PG Metabolite chemspider:8593139 wikidata:Q42403337 inchikey:MPTSWFXLMIATGU-YTWBPVBXSA-N -PI Metabolite chemspider:20058759 wikidata:Q42403300 inchikey:IBUKXRINTKQBRQ-PZDJRWDQSA-N -lysoPC Metabolite chemspider:24766528 wikidata:Q27160591 chebi:88697;chebi:88697 inchikey:WKQNRCYKYCKESD-YVHLTTHBSA-N -TAG Metabolite chemspider:4575640 wikidata:Q27145591 chebi:75845;chebi:75845 inchikey:UBEIMDKGOYBUKT-FLIQGJDUSA-N +Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps +Lactic acid Metabolite hmdb:HMDB0000190 "" chebi:422 inchikey:JVTAAEKCZFNVCJ-REOHCLBHSA-N pubchem.compound:107689 chemspider:96860 hmdb:HMDB0000190 kegg.compound:C00186 +Glycerol 3-phosphate Metabolite hmdb:HMDB0000126 "" chebi:15978 inchikey:AWUCVROLDVIAJX-GSVOUGTGSA-N pubchem.compound:439162 chemspider:388308 hmdb:HMDB0000126 kegg.compound:C00093 +GABA Metabolite hmdb:HMDB0000112 "" chebi:16865 inchikey:BTCSSZJGUNDROE-UHFFFAOYSA-N pubchem.compound:119 chemspider:116 hmdb:HMDB0000112 kegg.compound:C00334 +Cystine Metabolite hmdb:HMDB0000192 "" chebi:16283 inchikey:LEVWYRKDKASIDU-IMJSIDKUSA-N pubchem.compound:67678 chemspider:60997 hmdb:HMDB0000192 kegg.compound:C00491 +Dihydrouracil Metabolite hmdb:HMDB0000076 "" chebi:15901 inchikey:OIVLITBTBDPEFK-UHFFFAOYSA-N pubchem.compound:649 chemspider:629 hmdb:HMDB0000076 kegg.compound:C00429 +Pyruvic acid Metabolite hmdb:HMDB0000243 "" chebi:32816 inchikey:LCTONWCANYUPML-UHFFFAOYSA-N pubchem.compound:1060 hmdb:HMDB0000243 kegg.compound:C00022 +Leucine Metabolite hmdb:HMDB0000687 "" chebi:15603 inchikey:ROHFNLRQFUQHCH-YFKPBYRVSA-N pubchem.compound:6106 chemspider:5880 hmdb:HMDB0000687 kegg.compound:C00123 +Galactinol Metabolite hmdb:HMDB0005826 "" chebi:17505 inchikey:VCWMRQDBPZKXKG-DXNLKLAMSA-N pubchem.compound:381832774 chemspider:19402461 hmdb:HMDB0005826 kegg.compound:C01235 +Glucose Metabolite hmdb:HMDB0000122 "" chebi:15903 inchikey:WQZGKKKJIJFFOK-VFUOTHLCSA-N pubchem.compound:64689 chemspider:58238 hmdb:HMDB0000122 kegg.compound:C00221 +Xylose Metabolite hmdb:HMDB0000098 "" chebi:53455 inchikey:SRBFZHDQGSBBOR-IOVATXLUSA-N pubchem.compound:135191 chemspider:119104 hmdb:HMDB0000098 kegg.compound:C00181 +Threonine Metabolite hmdb:HMDB0000167 "" chebi:16857 inchikey:AYFVYJQAPQTCCC-GBXIJSLDSA-N pubchem.compound:6288 chemspider:6051 hmdb:HMDB0000167 kegg.compound:C00188 +Glutamic acid Metabolite hmdb:HMDB0000148 "" chebi:16015 inchikey:WHUUTDBJXJRKMK-VKHMYHEASA-N pubchem.compound:33032 hmdb:HMDB0000148 kegg.compound:C00025 +Nicotinic acid Metabolite hmdb:HMDB0001488 "" chebi:15940 inchikey:PVNIIMVLHYAWGP-UHFFFAOYSA-N pubchem.compound:938 chemspider:913 hmdb:HMDB0001488 kegg.compound:C00253 +Threonic acid Metabolite hmdb:HMDB0000943 "" chebi:15908 inchikey:JPIJQSOTBSSVTP-STHAYSLISA-N pubchem.compound:5460407 chemspider:4573940 hmdb:HMDB0000943 kegg.compound:C01620 +Mannose Metabolite hmdb:HMDB0000169 "" chebi:28729 inchikey:WQZGKKKJIJFFOK-PQMKYFCFSA-N pubchem.compound:185698 chemspider:161434 hmdb:HMDB0000169 kegg.compound:C00936 +Fructose 1,6-bisphosphate Metabolite hmdb:HMDB0001058 "" chebi:28013 inchikey:RNBGYGVWRKECFJ-ARQDHWQXSA-N pubchem.compound:10267 chemspider:9848 hmdb:HMDB0001058 kegg.compound:C05378 +Glyceric acid Metabolite hmdb:HMDB0000139 "" chebi:32398 inchikey:RBNPOMFGQQGHHO-UWTATZPHSA-N pubchem.compound:439194 chemspider:388334 hmdb:HMDB0000139 kegg.compound:C00258 +Serine Metabolite hmdb:HMDB0000187 "" chebi:17115 inchikey:MTCFGRXMJLQNBG-REOHCLBHSA-N pubchem.compound:5951 chemspider:5736 hmdb:HMDB0000187 kegg.compound:C00065 +Glucose-6-phosphate Metabolite hmdb:HMDB0001401 "" chebi:4170 inchikey:NBSCHQHZLSJFNQ-GASJEMHNSA-N pubchem.compound:5958 chemspider:5743 hmdb:HMDB0001401 kegg.compound:C00092 +Myo-inositol 1-phosphate Metabolite hmdb:HMDB0000213 "" chebi:18297 inchikey:INAPMGSXUVUWAF-UOTPTPDRSA-N chemspider:10375592 hmdb:HMDB0000213 kegg.compound:C01177 +Campesterol Metabolite hmdb:HMDB0002869 "" chebi:28623 inchikey:SGNBVLSWZMBQTH-PODYLUTMSA-N pubchem.compound:173183 chemspider:151215 hmdb:HMDB0002869 kegg.compound:C01789 +Sucrose Metabolite kegg.compound:C00089 "" wikidata:Q4027534 chebi:17992 inchikey:CZMRCDWAGMRECN-UGDNZRGBSA-N pubchem.compound:5988 chemspider:5768 hmdb:HMDB0000258 kegg.compound:C00089 +Ascorbic acid Metabolite hmdb:HMDB0000044 "" chebi:29073 inchikey:CIWBSHSKHKDKBQ-JLAZNSOCSA-N chemspider:10189562 hmdb:HMDB0000044 kegg.compound:C01041 +Homocysteine Metabolite hmdb:HMDB0000742 "" chebi:17588 inchikey:FFFHZYDWPBMWHY-VKHMYHEASA-N pubchem.compound:91552 chemspider:82666 hmdb:HMDB0000742 kegg.compound:C00155 +Glycine Metabolite hmdb:HMDB0000123 "" chebi:15428 inchikey:DHMQDGOQFOQNFH-UHFFFAOYSA-N pubchem.compound:750 chemspider:730 hmdb:HMDB0000123 kegg.compound:C00037 +Glycerol 2-phosphate Metabolite kegg.compound:C02979 "" wikidata:Q21099098 chebi:17270 inchikey:DHCLVCXQIBBOPH-UHFFFAOYSA-N pubchem.compound:2526 chemspider:2431 hmdb:HMDB0002520 kegg.compound:C02979 +Fructose Metabolite hmdb:HMDB0000660 "" chebi:28645 inchikey:RFSUNEUAIZKAJO-ARQDHWQXSA-N pubchem.compound:439709 chemspider:388775 hmdb:HMDB0000660 kegg.compound:C02336 +Homoserine Metabolite hmdb:HMDB0000719 "" chebi:15699 inchikey:UKAUYVFTDYCKQA-VKHMYHEASA-N pubchem.compound:12647 chemspider:12126 hmdb:HMDB0000719 kegg.compound:C00263 +Phytol Metabolite hmdb:HMDB0002019 "" chebi:17327 inchikey:BOTWFXYSPFMFNR-PYDDKJGSSA-N pubchem.compound:5280435 chemspider:4444094 hmdb:HMDB0002019 kegg.compound:C01389 +Cysteine Metabolite hmdb:HMDB0000574 "" chebi:17561 inchikey:XUJNEKJLAYXESH-REOHCLBHSA-N pubchem.compound:5862 chemspider:5653 hmdb:HMDB0000574 kegg.compound:C00097 +3-Phosphoglyceric acid Metabolite hmdb:HMDB0000807 "" chebi:17050 inchikey:OSJPPGNTCRNQQC-UHFFFAOYSA-N pubchem.compound:724 chemspider:704 hmdb:HMDB0000807 kegg.compound:C00597 +Beta-Sitosterol Metabolite hmdb:HMDB0000852 "" chebi:27693 inchikey:KZJWDPNRJALLNS-VJSFXXLFSA-N pubchem.compound:222284 chemspider:192962 hmdb:HMDB0000852 kegg.compound:C01753 +Alanine Metabolite hmdb:HMDB0000161 "" chebi:16977 inchikey:QNAYBMKLOCPYGJ-REOHCLBHSA-N pubchem.compound:5950 chemspider:5735 hmdb:HMDB0000161 kegg.compound:C00041 +Rhamnose Metabolite hmdb:HMDB0000849 "" chebi:62346 inchikey:SHZGCJCMOBCMKK-JFNONXLTSA-N pubchem.compound:25310 chemspider:23642 hmdb:HMDB0000849 kegg.compound:C00507 +Maltose Metabolite hmdb:HMDB0000163 "" chebi:47937 inchikey:GUBGYTABKSRVRQ-DKBJLJRDSA-N pubchem.compound:10991489 chemspider:9166684 hmdb:HMDB0000163 kegg.compound:C00208 +Phosphoenolpyruvic acid Metabolite hmdb:HMDB0000263 "" chebi:44897 inchikey:DTBNBXWJWCWCIK-UHFFFAOYSA-N pubchem.compound:1005 chemspider:980 hmdb:HMDB0000263 kegg.compound:C00074 +Succinyl-CoA Metabolite hmdb:HMDB0001022 "" chebi:15380 inchikey:VNOYUJKHFWYWIR-ITIYDSSPSA-N pubchem.compound:92133 chemspider:83179 hmdb:HMDB0001022 kegg.compound:C00091 +Isorhamnetin Metabolite hmdb:HMDB0002655 "" chebi:6052 inchikey:IZQSVPBOUDKVDZ-UHFFFAOYSA-N pubchem.compound:5281654 chemspider:4444973 hmdb:HMDB0002655 kegg.compound:C10084 +Acetyl-CoA Metabolite hmdb:HMDB0001206 "" chebi:15351 inchikey:ZSLZBFCDCINBPY-ZSJPKINUSA-N pubchem.compound:444493 chemspider:392413 hmdb:HMDB0001206 kegg.compound:C00024 +Dehydroascorbic acid Metabolite hmdb:HMDB0001264 "" chebi:27956 inchikey:SBJKKFFYIZUCET-JLAZNSOCSA-N pubchem.compound:440667 chemspider:389547 hmdb:HMDB0001264 kegg.compound:C05422 +Oxaloacetic acid Metabolite hmdb:HMDB0000223 "" chebi:30744 inchikey:KHPXUQMNIQBQEV-UHFFFAOYSA-N pubchem.compound:970 chemspider:945 hmdb:HMDB0000223 kegg.compound:C00036 +Myoinositol Metabolite hmdb:HMDB0000211 "" chebi:17268 inchikey:CDAISMWEOUEBRE-GPIVLXJGSA-N chemspider:10239179 hmdb:HMDB0000211 kegg.compound:C00137 +Fructose-6-phosphate Metabolite hmdb:HMDB0000124 "" chebi:15946 inchikey:GSXOAOHZAIYLCY-HSUXUTPPSA-N pubchem.compound:69507 chemspider:62713 hmdb:HMDB0000124 kegg.compound:C00085 +Raffinose Metabolite hmdb:HMDB0003213 "" chebi:16634 inchikey:MUPFEKGTMRGPLJ-ZQSKZDJDSA-N pubchem.compound:439242 chemspider:388379 hmdb:HMDB0003213 kegg.compound:C00492 +Nicotianamine Metabolite kegg.compound:C05324 "" wikidata:Q11324211 chebi:17721 inchikey:KRGPXXHMOXVMMM-CIUDSAMLSA-N pubchem.compound:9882882 chemspider:8058557 kegg.compound:C05324 +Galacturonic acid Metabolite hmdb:HMDB0002545 "" chebi:47962 inchikey:IAJILQKETJEXLJ-RSJOWCBRSA-N pubchem.compound:84740 chemspider:76444 hmdb:HMDB0002545 kegg.compound:C08348 +Arabinose Metabolite hmdb:HMDB0029942 "" chebi:46996 inchikey:SRBFZHDQGSBBOR-SQOUGZDYSA-N pubchem.compound:444173 chemspider:392169 hmdb:HMDB0029942 +Ribose Metabolite hmdb:HMDB0000283 "" chebi:47013 inchikey:HMFHBZSHGGEWLO-SOOFDHNKSA-N pubchem.compound:5779 chemspider:5575 hmdb:HMDB0000283 kegg.compound:C00121 +Trehalose Metabolite hmdb:HMDB0000975 "" chebi:16551 inchikey:HDTRYLNUVZCQOY-LIZSDCNHSA-N pubchem.compound:7427 chemspider:7149 hmdb:HMDB0000975 kegg.compound:C01083 +Lysine Metabolite hmdb:HMDB0000182 "" chebi:18019 inchikey:KDXKERNSBIXSRK-YFKPBYRVSA-N pubchem.compound:5962 chemspider:5747 hmdb:HMDB0000182 kegg.compound:C00047 +Aspartic acid Metabolite hmdb:HMDB0000191 "" chebi:17053 inchikey:CKLJMWTZIZZHCS-REOHCLBHSA-N pubchem.compound:5960 chemspider:5745 hmdb:HMDB0000191 kegg.compound:C00049 +Beta-Alanine Metabolite hmdb:HMDB0000056 "" chebi:16958 inchikey:UCMIRNVEIXFBKS-UHFFFAOYSA-N pubchem.compound:239 chemspider:234 hmdb:HMDB0000056 kegg.compound:C00099 +Valine Metabolite hmdb:HMDB0000883 "" chebi:16414 inchikey:KZSNJWFQEVHDMF-BYPYZUCNSA-N pubchem.compound:6287 chemspider:6050 hmdb:HMDB0000883 kegg.compound:C00183 +Uracil Metabolite hmdb:HMDB0000300 "" chebi:17568 inchikey:ISAKRJDGNUQOIC-UHFFFAOYSA-N pubchem.compound:1174 chemspider:1141 hmdb:HMDB0000300 kegg.compound:C00106 +Isoleucine Metabolite hmdb:HMDB0000172 "" chebi:17191 inchikey:AGPKZVBTJJNPAG-WHFBIAKZSA-N pubchem.compound:6306 chemspider:6067 hmdb:HMDB0000172 kegg.compound:C00407 +Asparagine Metabolite hmdb:HMDB0000168 "" chebi:17196 inchikey:DCXYFEDJOCDNAF-REOHCLBHSA-N pubchem.compound:6267 chemspider:6031 hmdb:HMDB0000168 kegg.compound:C00152 +Citric acid Metabolite hmdb:HMDB0000094 "" chebi:30769 inchikey:KRKNYBCHXYNGOX-UHFFFAOYSA-N pubchem.compound:311 chemspider:305 hmdb:HMDB0000094 kegg.compound:C00158 +Isocitric acid Metabolite hmdb:HMDB0000193 "" chebi:30887 inchikey:ODBLHEXUDAPZAU-UHFFFAOYSA-N pubchem.compound:1198 chemspider:1161 hmdb:HMDB0000193 kegg.compound:C00311 +cis-Aconitic acid Metabolite hmdb:HMDB0000072 "" chebi:32805 inchikey:GTZCVFVGUGFEME-IWQZZHSRSA-N pubchem.compound:643757 chemspider:558863 hmdb:HMDB0000072 kegg.compound:C00417 +2-Oxo-glutaric acid Metabolite hmdb:HMDB0000208 "" chebi:30915 inchikey:KPGXRSRHYNQIFN-UHFFFAOYSA-N pubchem.compound:51 chemspider:50 hmdb:HMDB0000208 kegg.compound:C00026 +Succinic acid Metabolite hmdb:HMDB0000254 "" chebi:15741 inchikey:KDYFGRWQOYBRFD-UHFFFAOYSA-N pubchem.compound:1738118 chemspider:1078 hmdb:HMDB0000254 kegg.compound:C00042 +Fumaric acid Metabolite hmdb:HMDB0000134 "" chebi:18012 inchikey:VZCYOOQTPOCHFL-OWOJBTEDSA-N pubchem.compound:444972 chemspider:10197150 hmdb:HMDB0000134 kegg.compound:C00122 +Malic acid Metabolite hmdb:HMDB0000744 "" +Methionine Metabolite hmdb:HMDB0000696 "" chebi:16643 inchikey:FFEARJCKVFRZRR-BYPYZUCNSA-N pubchem.compound:6137 chemspider:5907 hmdb:HMDB0000696 kegg.compound:C00073 +S-Adenosylmethionine Metabolite hmdb:HMDB0001185 "" chebi:15414 inchikey:MEFKEPWMEQBLKI-AIRLBKTGSA-O pubchem.compound:34756 chemspider:21169292 hmdb:HMDB0001185 kegg.compound:C00019 +Arginine Metabolite hmdb:HMDB0000517 "" chebi:16467 inchikey:ODKSFYDXXFIFQN-BYPYZUCNSA-N pubchem.compound:6322 chemspider:6082 hmdb:HMDB0000517 kegg.compound:C00062 +Glutamine Metabolite hmdb:HMDB0000641 "" chebi:18050 inchikey:ZDXPYRJPNDTMRX-VKHMYHEASA-N pubchem.compound:5961 chemspider:5746 hmdb:HMDB0000641 kegg.compound:C00064 +Histidine Metabolite hmdb:HMDB0000177 "" chebi:15971 inchikey:HNDVDQJCIGZPNO-YFKPBYRVSA-N pubchem.compound:6274 chemspider:6038 hmdb:HMDB0000177 kegg.compound:C00135 +Proline Metabolite hmdb:HMDB0000162 "" chebi:17203 inchikey:ONIBWKKTOPOVIA-BYPYZUCNSA-N pubchem.compound:145742 chemspider:128566 hmdb:HMDB0000162 kegg.compound:C00148 +Ornithine Metabolite hmdb:HMDB0000214 "" chebi:15729 inchikey:AHLPHDHHMVZTML-BYPYZUCNSA-N pubchem.compound:6262 chemspider:6026 hmdb:HMDB0000214 kegg.compound:C00077 +Hydroxylamine Metabolite hmdb:HMDB0003338 "" chebi:15429 inchikey:AVXURJPOCDRRFD-UHFFFAOYSA-N pubchem.compound:787 chemspider:766 hmdb:HMDB0003338 kegg.compound:C00192 +Putrescine Metabolite hmdb:HMDB0001414 "" chebi:17148 inchikey:KIDHWZJUCRJVML-UHFFFAOYSA-N pubchem.compound:1045 chemspider:13837702 hmdb:HMDB0001414 kegg.compound:C00134 +Spermidine Metabolite hmdb:HMDB0001257 "" chebi:16610 inchikey:ATHGHQPFGPMSJY-UHFFFAOYSA-N pubchem.compound:1102 chemspider:1071 hmdb:HMDB0001257 kegg.compound:C00315 +Ethanolamine Metabolite hmdb:HMDB0000149 "" chebi:16000 inchikey:HZAXFHJVJLSVMW-UHFFFAOYSA-N pubchem.compound:700 chemspider:13835336 hmdb:HMDB0000149 kegg.compound:C00189 +F1 Metabolite kegg.compound:C16981 "" wikidata:Q6345965 chebi:68883 inchikey:PUPKKEQDLNREIM-QNSQPKOQSA-N pubchem.compound:5486199 chemspider:4588900 hmdb:HMDB0037438 kegg.compound:C16981 lipidmaps:LMPK12111865 +Shikimic acid Metabolite hmdb:HMDB0003070 "" chebi:16119 inchikey:JXOHGGNKMLTUBP-HSUXUTPPSA-N pubchem.compound:8742 chemspider:8412 hmdb:HMDB0003070 kegg.compound:C00493 +Quinic acid Metabolite hmdb:HMDB0003072 "" chebi:17521 inchikey:AAWZDTNXLSGCEK-WYWMIBKRSA-N pubchem.compound:6508 chemspider:10246715 hmdb:HMDB0003072 kegg.compound:C00296 +Phenylalanine Metabolite hmdb:HMDB0000159 "" chebi:17295 inchikey:COLNVLDHVKWLRT-QMMMGPOBSA-N pubchem.compound:6140 chemspider:5910 hmdb:HMDB0000159 kegg.compound:C00079 +F2 Metabolite knapsack:C00005184 "" wikidata:Q23058972 inchikey:JYXSWDCPHRTYGU-KSAWAZCGSA-N pubchem.compound:139031089 +Tryptophan Metabolite hmdb:HMDB0000929 "" chebi:16828 inchikey:QIVBCDIJIAJPQS-VIFPVBQESA-N pubchem.compound:6305 chemspider:6066 hmdb:HMDB0000929 kegg.compound:C00078 +Tyrosine Metabolite hmdb:HMDB0000158 "" chebi:17895 inchikey:OUYCCCASQSFEME-QMMMGPOBSA-N pubchem.compound:6057 chemspider:5833 hmdb:HMDB0000158 kegg.compound:C00082 +F5 Metabolite knapsack:C00005432 "" wikidata:Q23418551 chebi:133245 inchikey:GXLQUHPXGLZNGE-BRHFUIPOSA-N pubchem.compound:139031037 lipidmaps:LMPK12112200 +F6 Metabolite knapsack:C00005428 "" wikidata:Q56236938 inchikey:OTUCXMIQUNROBJ-FVQHZYONNA-N +F3 Metabolite knapsack:C00005237 "" wikidata:Q23417468 inchikey:DDELFAUOHDSZJL-JEHSZLPQSA-N pubchem.compound:139031035 +F4 Metabolite knapsack:C00005234 "" wikidata:Q23417271 chebi:133218 inchikey:QFSDWLPMRWDFID-CSNYLUTCSA-N pubchem.compound:10652679 lipidmaps:LMPK12111762 +Tryptamine Metabolite hmdb:HMDB0000303 "" chebi:16765 inchikey:APJYDQYYACXCRM-UHFFFAOYSA-N pubchem.compound:1150 chemspider:1118 hmdb:HMDB0000303 kegg.compound:C00398 +Triethanolamine Metabolite hmdb:HMDB0032538 "" chebi:28621 inchikey:GSEJCLTVZPLZKY-UHFFFAOYSA-N pubchem.compound:7618 chemspider:13835630 hmdb:HMDB0032538 kegg.compound:C06771 +Benzoic acid Metabolite hmdb:HMDB0001870 "" chebi:30746 inchikey:WPYMKLBDIGXBTP-UHFFFAOYSA-N pubchem.compound:243 chemspider:238 hmdb:HMDB0001870 kegg.compound:C00539 +Caffeic acid Metabolite hmdb:HMDB0001964 "" chebi:16433 inchikey:QAIPRVGONGVQAS-DUXPYHPUSA-N pubchem.compound:689043 chemspider:600426 hmdb:HMDB0001964 kegg.compound:C01481 +Alpha-Tocopherol Metabolite hmdb:HMDB0001893 "" chebi:18145 inchikey:GVJHHUAWPYXKBD-IEOSBIPESA-N pubchem.compound:14985 chemspider:14265 hmdb:HMDB0001893 kegg.compound:C02477 +Tyramine Metabolite hmdb:HMDB0000306 "" chebi:15760 inchikey:DZGWFCGJZKJUFP-UHFFFAOYSA-N pubchem.compound:5610 chemspider:5408 hmdb:HMDB0000306 kegg.compound:C00483 +A1 Metabolite kegg.compound:C20493 "Cyanidin 3-sambubioside-5-glucoside" wikidata:Q23419061 inchikey:OLBLWNPOURNBCY-QFEPKXLGSA-O pubchem.compound:139031039 kegg.compound:C20493 +A2 Metabolite knapsack:C00007655 "" wikidata:Q23449332 inchikey:CVAUKYVPQCYVDV-IPDRLXFSSA-O pubchem.compound:44256799 +A5 Metabolite knapsack:C00007657 "" wikidata:Q23464928 inchikey:JKGXHHXZZLNEGD-XUYFGVRGSA-O +A6 Metabolite knapsack:C00007658 "" wikidata:Q23462761 inchikey:OPWPCWHMCUWCGG-VTRYSJNRSA-O pubchem.compound:44256802 +A3 Metabolite knapsack:C00006836 "" wikidata:Q23419072 inchikey:JSYDBTWJIIAZPU-OMLFMJQWSA-O pubchem.compound:139031040 +A4 Metabolite knapsack:C00007656 "" wikidata:Q23464998 inchikey:HKRACDHMWOGFKJ-BPVIEZTISA-O pubchem.compound:44256800 +A7 Metabolite knapsack:C00007660 "" wikidata:Q23462624 inchikey:ABJDYMVXHLYTHZ-DULZENQLSA-O +A8 Metabolite knapsack:C00007659 "" wikidata:Q23462702 inchikey:NXTHTMNXJOEVLR-JHBYNAJCSA-O +A11 Metabolite knapsack:C00007570 "" wikidata:Q23449331 inchikey:QRNIDVBVORPNBX-WSXZECFZSA-O +A9 Metabolite knapsack:C00006838 "" wikidata:Q23419083 inchikey:MAKMINQMKSULBY-HHNMOXDYSA-O +A10 Metabolite knapsack:C00007661 "" wikidata:Q23462550 inchikey:QPUCGPFRKWVURQ-SLWMWEMUSA-O +F7 Metabolite kegg.compound:C19796 "" wikidata:Q23418549 chebi:133244 inchikey:MCTZMXCUYPDYNE-AHHFARBASA-N pubchem.compound:6325870 kegg.compound:C19796 lipidmaps:LMPK12112199 +F8 Metabolite knapsack:C00005470 "" wikidata:Q23418553 inchikey:WLPJMCCYDZFCBL-JJSAVOBRSA-N pubchem.compound:139031038 +F14 Metabolite knapsack:C00005557 "" wikidata:Q45410367 inchikey:NEJKEXUJCSYMCC-AKTJOMHVSA-N pubchem.compound:139033597 +F15 Metabolite knapsack:C00005558 "" wikidata:Q23049771 inchikey:UWQOGHWNWIJMNI-SZBCTZJWSA-N pubchem.compound:139031077 +F19 Metabolite knapsack:C00005174 "" wikidata:Q23058968 inchikey:JIGYKOJSDSJFFW-DBFSWMNWSA-N pubchem.compound:139031088 +F23 Metabolite knapsack:C00005368 "" wikidata:Q23417673 inchikey:PZZRDJXEMZMZFD-SQIUQIIDSA-N pubchem.compound:51652818 +F20 Metabolite knapsack:C00005188 "" wikidata:Q23048396 inchikey:MBLYALXOUBKFNE-NAYQWVCRSA-N pubchem.compound:90795788 +F24 Metabolite kegg.compound:C01750 "" wikidata:Q1649777 chebi:17558 inchikey:OXGUCUVFOIWWQJ-HQBVPOQASA-N pubchem.compound:5280459 chemspider:4444112 hmdb:HMDB0033751 kegg.compound:C01750 lipidmaps:LMPK12112171 +F27 Metabolite knapsack:C00005526 "" wikidata:Q23049767 inchikey:UXXAEVMOIUAYQT-KEXGRDQZSA-N pubchem.compound:139031076 +F28 Metabolite knapsack:C00005525 "" wikidata:Q23049780 inchikey:CQLRUIIRRZYHHS-BYXQHVMRSA-N pubchem.compound:51402809 +F29 Metabolite knapsack:C00005551 "" wikidata:Q23049759 inchikey:UIXIEXAWTSBGCB-PLZSGXCYSA-N pubchem.compound:139031075 +F30 Metabolite knapsack:C00005559 "" wikidata:Q23049774 inchikey:UNMZJSVCTCKOEC-QPPFPMOSSA-N pubchem.compound:139031078 +Quercetin Metabolite hmdb:HMDB0005794 "" chebi:16243 inchikey:REFJWTPEDVJJIY-UHFFFAOYSA-N pubchem.compound:5280343 chemspider:4444051 hmdb:HMDB0005794 kegg.compound:C00389 +Kaempferol Metabolite hmdb:HMDB0005801 "" chebi:28499 inchikey:IYRMWMYZSQPJKC-UHFFFAOYSA-N pubchem.compound:5280863 chemspider:4444395 hmdb:HMDB0005801 kegg.compound:C05903 +Cyanidin Metabolite chebi:27843 "" wikidata:Q417606 chebi:27843 inchikey:VEVZSMAEJFVWIL-UHFFFAOYSA-O pubchem.compound:128861 chemspider:114193 hmdb:HMDB0002708 kegg.compound:C05905 lipidmaps:LMPK12010002 +Gluconic acid Metabolite hmdb:HMDB0000625 "" chebi:33198 inchikey:RGHNJXZEOKUKBD-SQOUGZDYSA-N pubchem.compound:10690 chemspider:10240 hmdb:HMDB0000625 kegg.compound:C00257 +Glutathione Metabolite hmdb:HMDB0000125 "" chebi:16856 inchikey:RWSXRVCMGQZWBV-WDSKDSINSA-N pubchem.compound:124886 chemspider:111188 hmdb:HMDB0000125 kegg.compound:C00051 +glycerate 3-phosphate Metabolite hmdb:HMDB0000807 "" chebi:17050 inchikey:OSJPPGNTCRNQQC-UHFFFAOYSA-N pubchem.compound:724 chemspider:704 hmdb:HMDB0000807 kegg.compound:C00597 +C14:0 Metabolite hmdb:HMDB0000806 "" chebi:28875 inchikey:TUNFSRHWOTWDNC-UHFFFAOYSA-N pubchem.compound:11005 chemspider:10539 hmdb:HMDB0000806 kegg.compound:C06424 +C16:0 Metabolite hmdb:HMDB0000220 "" chebi:15756 inchikey:IPCSVZSSVZVIGE-UHFFFAOYSA-N pubchem.compound:985 chemspider:960 hmdb:HMDB0000220 kegg.compound:C00249 +C18:0 Metabolite hmdb:HMDB0000827 "" chebi:28842 inchikey:QIQXTHQIDYTFRH-UHFFFAOYSA-N pubchem.compound:5281 chemspider:5091 hmdb:HMDB0000827 kegg.compound:C01530 +C18:2 Metabolite hmdb:HMDB0000673 "" chebi:17351 inchikey:OYHQOLUKZRVURQ-HZJYTTRNSA-N pubchem.compound:5280450 chemspider:4444105 hmdb:HMDB0000673 kegg.compound:C01595 +C18:3 Metabolite hmdb:HMDB0001388 "" chebi:27432 inchikey:DTOSIQBPPRVQHS-PDBXOOCHSA-N pubchem.compound:5280934 chemspider:4444437 hmdb:HMDB0001388 kegg.compound:C06427 +C24:0 Metabolite hmdb:HMDB0002003 "" chebi:28866 inchikey:QZZGJDVWLFXDLK-UHFFFAOYSA-N pubchem.compound:11197 chemspider:10724 hmdb:HMDB0002003 kegg.compound:C08320 +Cholesterol Metabolite hmdb:HMDB0000067 "" chebi:16113 inchikey:HVYWMOMLDIMFJA-DPAQBDIFSA-N pubchem.compound:5997 hmdb:HMDB0000067 kegg.compound:C00187 +Stigmasterol Metabolite hmdb:HMDB0000937 "" chebi:28824 inchikey:HCXVJBMSMIARIN-PHZDYDNGSA-N pubchem.compound:5280794 chemspider:4444352 hmdb:HMDB0000937 kegg.compound:C05442 +Glutaric acid Metabolite hmdb:HMDB0000661 "" chebi:17859 inchikey:JFCQEDHGNNZCLN-UHFFFAOYSA-N pubchem.compound:743 chemspider:723 hmdb:HMDB0000661 kegg.compound:C00489 +Salicylic acid Metabolite hmdb:HMDB0001895 "" chebi:16914 inchikey:YGSDEFSMJLZEOE-UHFFFAOYSA-N pubchem.compound:338 chemspider:331 hmdb:HMDB0001895 kegg.compound:C00805 +3-MTP Metabolite kegg.compound:C08412 "" wikidata:Q27106759 chebi:79326;chebi:5407 inchikey:ZCZCVJVUJGULMO-IIPHORNXSA-M pubchem.compound:20843347 kegg.compound:C08412 +3-MSOP Metabolite kegg.compound:C08405 "" wikidata:Q27106752 chebi:5400 inchikey:OFKKQTQFWWIRBD-ZHVGPZTNSA-M pubchem.compound:656530 chemspider:570908 kegg.compound:C08405 +4-MSOB Metabolite kegg.compound:C08410 "" wikidata:Q27106757 chebi:5405 inchikey:WJMGSLJQEIYHOF-URYVQPGZSA-M pubchem.compound:656540 chemspider:570916 kegg.compound:C08410 +4-MTB Metabolite kegg.compound:C08409 "" wikidata:Q27106756 chebi:79325;chebi:5404 inchikey:GKUMMDFLKGFCKH-AHMUMSBHSA-N;inchikey:GKUMMDFLKGFCKH-AHMUMSBHSA-M pubchem.compound:6537200;pubchem.compound:6537199 chemspider:5020505 hmdb:HMDB0038403 kegg.compound:C08409 +5-MTP Metabolite kegg.compound:C08401 "" wikidata:Q27106749 chebi:79324;chebi:5396 inchikey:MEFPHTVXBPLRLX-CBEPRAPJSA-M;inchikey:MEFPHTVXBPLRLX-ZMHPAJMFSA-N pubchem.compound:656525;pubchem.compound:20843360 chemspider:570904 hmdb:HMDB0301919 kegg.compound:C08401 +5-MSOP Metabolite kegg.compound:C08400 "" wikidata:Q27106748 chebi:5395 inchikey:HUCGRJSHMZWRQQ-PWGYDFSISA-N pubchem.compound:9589398 chemspider:7863545 kegg.compound:C08400 +6-MTH Metabolite knapsack:C00007844 "" wikidata:Q27154956 chebi:80987 inchikey:ZAKICGFSIJSCSF-LPUQOGTASA-N pubchem.compound:46173875 chemspider:30791700 kegg.compound:C17250 +6-MSOH Metabolite knapsack:C00007348 "" wikidata:Q59571080 chebi:136956 inchikey:OOGAQHVYHLPICD-DNDZILKHSA-N pubchem.compound:134160269 +7-MTH Metabolite knapsack:C00007353 "" wikidata:Q27154957 chebi:80988 inchikey:SJHVRBSHKTUXLG-LFHLZQBKSA-N pubchem.compound:46173876 chemspider:30791699 kegg.compound:C17252 +7-MSOH Metabolite knapsack:C00007352 "" wikidata:Q59571113 chebi:132553 inchikey:LQZALQLZOQQFGM-MMLSCURJSA-N pubchem.compound:124079390 chemspider:24784931 +8-MTO Metabolite knapsack:C00007356 "" wikidata:Q27154958 chebi:80989 inchikey:CWOJBEDMJKZKAB-JZYAIQKZSA-N pubchem.compound:46173877 chemspider:30791698 kegg.compound:C17254 +8-MSOO Metabolite knapsack:C00007355 "" wikidata:Q27154960 chebi:80998 inchikey:GPMDJOOLATZDQL-OTNWBXTQSA-N pubchem.compound:101613195 kegg.compound:C17271 +PA Metabolite kegg.compound:C00416 "" wikidata:Q66000256 chebi:16337 kegg.compound:C00416 +DAG Metabolite kegg.compound:C00165 "" wikidata:Q161466 chebi:18035 kegg.compound:C00165 lipidmaps:LMGL0201 +MGDG Metabolite chemspider:4696840 "" wikidata:Q42403321 chebi:169499 inchikey:QUZHZFAQJATMCA-NYFMCUGMSA-N pubchem.compound:5771744 chemspider:4696840 lipidmaps:LMGL05010001 +DGDG Metabolite chemspider:28495919 "" wikidata:Q42403316 chebi:136795 inchikey:KDYAPQVYJXUQNY-OPHDRXFHSA-N pubchem.compound:57400365 chemspider:28495919 +SQDG Metabolite chemspider:140119 "" wikidata:Q42403295 inchikey:RVUUQPKXGDTQPG-PINKXYAGSA-N pubchem.compound:159321 chemspider:140119 +PC Metabolite chemspider:4946694 "" wikidata:Q42403329 inchikey:XXKFQTJOJZELMD-RSLAUBRISA-N pubchem.compound:6442626 chemspider:4946694 +PE Metabolite chemspider:7825685 "" wikidata:Q42403336 inchikey:WIHSZOXPODIZSW-YTWBPVBXSA-N pubchem.compound:9546735 chemspider:7825685 +PG Metabolite chemspider:8593139 "" wikidata:Q42403337 inchikey:MPTSWFXLMIATGU-YTWBPVBXSA-N pubchem.compound:10417707 chemspider:8593139 +PI Metabolite chemspider:20058759 "" wikidata:Q42403300 inchikey:IBUKXRINTKQBRQ-PZDJRWDQSA-N chemspider:20058759 +lysoPC Metabolite chemspider:24766528 "" wikidata:Q27160591 chebi:88697 inchikey:WKQNRCYKYCKESD-YVHLTTHBSA-N pubchem.compound:24779469 chemspider:24766528 hmdb:HMDB0010388 lipidmaps:LMGP01050038 +TAG Metabolite chemspider:4575640 "" wikidata:Q27145591 chebi:75845 inchikey:UBEIMDKGOYBUKT-FLIQGJDUSA-N pubchem.compound:5462874 chemspider:4575640 hmdb:HMDB0055309 lipidmaps:LMGL03010527 diff --git a/pathways/WP3622/WP3622.gpml b/pathways/WP3622/WP3622.gpml index 7f0bc22e6..da8ca8f04 100644 --- a/pathways/WP3622/WP3622.gpml +++ b/pathways/WP3622/WP3622.gpml @@ -1,5 +1,5 @@ - + Since early 2000, a number of metabolome analyses have been demonstrated using combined hyphenated chromatographic and mass spectral methods as well as nuclear-magnetic-resonance. Although metabolite profiling experiments are becoming routine in many research groups, making the studies remains expensive and laborious. While the metabolomics community is working towards the setup of sharing metabolome data, mining publicly available information and demonstrating the richness of integration of multiple metabolome datasets remain largely unexploited. The aims of this project are (1) to establish a new web-based platform for metabolome meta-analysis and (2) to use these sets of combined metabolite levels to explore the diversity of complex metabolic networks in the model plant, Arabidopsis thaliana. We constructed our database, called AtMetExpress (http://prime.psc.riken.jp/AtMetExpress/), to store the metabolome information. cb3 d35 @@ -383,7 +383,6 @@ Cyanidin 3-sambubioside-5-glucoside - Type your comment here b49 @@ -450,7 +449,6 @@ FL5FACGS0030 - Type your comment here @@ -483,8 +481,8 @@ - Isorhamnetin 3-neohesperidoside-7-rhamnoside - Type your comment here + Isorhamnetin 3-neohesperidoside-7-rhamnoside + @@ -674,946 +672,946 @@ - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + @@ -1622,11 +1620,6 @@ - - classic metabolic pathway - PW:0000002 - Pathway Ontology - 25342293 PubMed @@ -1647,6 +1640,11 @@ Fukushima A Kusano M + + classic metabolic pathway + PW:0000002 + Pathway Ontology + 23473981 PubMed @@ -1663,3 +1661,4 @@ + diff --git a/pathways/WP3622/WP3622.json b/pathways/WP3622/WP3622.json index 91bdf8a4d..76b1791d1 100644 --- a/pathways/WP3622/WP3622.json +++ b/pathways/WP3622/WP3622.json @@ -61,7 +61,8 @@ "CompactIdentifier:knapsack:C00005184", "F2", "Wikidata:Q23058972", - "InChI:JYXSWDCPHRTYGU-KSAWAZCGSA-N" + "InChI:JYXSWDCPHRTYGU-KSAWAZCGSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -101,8 +102,11 @@ "CompactIdentifier:hmdb:HMDB0001893", "Alpha-Tocopherol", "ChEBI:18145", - "ChEBI:18145", - "InChI:GVJHHUAWPYXKBD-IEOSBIPESA-N" + "InChI:GVJHHUAWPYXKBD-IEOSBIPESA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -136,7 +140,6 @@ 0.5 ] }, - "id": "f68de", "isAttachedTo": "b725d", "orientation": [ 1, @@ -156,7 +159,6 @@ 0.5 ] }, - "id": "db2ad", "isAttachedTo": "baf30", "orientation": [ 1, @@ -197,7 +199,6 @@ 0.5 ] }, - "id": "d884f", "isAttachedTo": "c30c7", "orientation": [ 1, @@ -217,7 +218,6 @@ 0.5 ] }, - "id": "ffbd0", "isAttachedTo": "baf30", "orientation": [ 1, @@ -264,8 +264,11 @@ "CompactIdentifier:hmdb:HMDB0000172", "Isoleucine", "ChEBI:17191", - "ChEBI:17191", - "InChI:AGPKZVBTJJNPAG-WHFBIAKZSA-N" + "InChI:AGPKZVBTJJNPAG-WHFBIAKZSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -305,8 +308,11 @@ "CompactIdentifier:hmdb:HMDB0001870", "Benzoic acid", "ChEBI:30746", - "ChEBI:30746", - "InChI:WPYMKLBDIGXBTP-UHFFFAOYSA-N" + "InChI:WPYMKLBDIGXBTP-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -340,7 +346,6 @@ 0.5 ] }, - "id": "a9e22", "isAttachedTo": "bae8d", "orientation": [ 1, @@ -360,7 +365,6 @@ 0.5 ] }, - "id": "c6f1e", "isAttachedTo": "b5b69", "orientation": [ 1, @@ -407,7 +411,10 @@ "MGDG", "Wikidata:Q42403321", "ChEBI:169499", - "InChI:QUZHZFAQJATMCA-NYFMCUGMSA-N" + "InChI:QUZHZFAQJATMCA-NYFMCUGMSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -447,8 +454,11 @@ "CompactIdentifier:hmdb:HMDB0000190", "Lactic acid", "ChEBI:422", - "ChEBI:422", - "InChI:JVTAAEKCZFNVCJ-REOHCLBHSA-N" + "InChI:JVTAAEKCZFNVCJ-REOHCLBHSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -488,8 +498,11 @@ "CompactIdentifier:hmdb:HMDB0002003", "C24:0", "ChEBI:28866", - "ChEBI:28866", - "InChI:QZZGJDVWLFXDLK-UHFFFAOYSA-N" + "InChI:QZZGJDVWLFXDLK-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -567,8 +580,11 @@ "CompactIdentifier:hmdb:HMDB0000126", "Glycerol 3-phosphate", "ChEBI:15978", - "ChEBI:15978", - "InChI:AWUCVROLDVIAJX-GSVOUGTGSA-N" + "InChI:AWUCVROLDVIAJX-GSVOUGTGSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -609,7 +625,7 @@ "PA", "Wikidata:Q66000256", "ChEBI:16337", - "ChEBI:16337" + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -650,8 +666,12 @@ "Cyanidin", "Wikidata:Q417606", "ChEBI:27843", - "ChEBI:27843", - "InChI:VEVZSMAEJFVWIL-UHFFFAOYSA-O" + "InChI:VEVZSMAEJFVWIL-UHFFFAOYSA-O", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -685,7 +705,6 @@ 1 ] }, - "id": "e6222", "isAttachedTo": "d054f", "orientation": [ 0, @@ -705,7 +724,6 @@ 0 ] }, - "id": "c8be0", "isAttachedTo": "d914e", "orientation": [ 0, @@ -784,8 +802,11 @@ "CompactIdentifier:hmdb:HMDB0000112", "GABA", "ChEBI:16865", - "ChEBI:16865", - "InChI:BTCSSZJGUNDROE-UHFFFAOYSA-N" + "InChI:BTCSSZJGUNDROE-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -825,8 +846,11 @@ "CompactIdentifier:hmdb:HMDB0000192", "Cystine", "ChEBI:16283", - "ChEBI:16283", - "InChI:LEVWYRKDKASIDU-IMJSIDKUSA-N" + "InChI:LEVWYRKDKASIDU-IMJSIDKUSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -867,8 +891,9 @@ "8-MSOO", "Wikidata:Q27154960", "ChEBI:80998", - "ChEBI:80998", - "InChI:GPMDJOOLATZDQL-OTNWBXTQSA-N" + "InChI:GPMDJOOLATZDQL-OTNWBXTQSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -902,7 +927,6 @@ 1 ] }, - "id": "a376d", "isAttachedTo": "b70f8", "orientation": [ 0, @@ -922,7 +946,6 @@ 0 ] }, - "id": "bda95", "isAttachedTo": "c37e2", "orientation": [ 0, @@ -962,7 +985,6 @@ 0.5 ] }, - "id": "fe04a", "isAttachedTo": "af28b", "orientation": [ 1, @@ -982,7 +1004,6 @@ 0.5 ] }, - "id": "f304f", "isAttachedTo": "baf30", "orientation": [ 1, @@ -1023,7 +1044,6 @@ 0 ] }, - "id": "c5aaa", "isAttachedTo": "d054f", "orientation": [ 0, @@ -1043,7 +1063,6 @@ 1 ] }, - "id": "a160c", "isAttachedTo": "b28f4", "orientation": [ 0, @@ -1089,8 +1108,11 @@ "CompactIdentifier:hmdb:HMDB0000076", "Dihydrouracil", "ChEBI:15901", - "ChEBI:15901", - "InChI:OIVLITBTBDPEFK-UHFFFAOYSA-N" + "InChI:OIVLITBTBDPEFK-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1124,7 +1146,6 @@ 0.5 ] }, - "id": "a1d30", "isAttachedTo": "af271", "orientation": [ -1, @@ -1144,7 +1165,6 @@ 0.5 ] }, - "id": "e10a5", "isAttachedTo": "cf606", "orientation": [ -1, @@ -1190,8 +1210,10 @@ "CompactIdentifier:hmdb:HMDB0000243", "Pyruvic acid", "ChEBI:32816", - "ChEBI:32816", - "InChI:LCTONWCANYUPML-UHFFFAOYSA-N" + "InChI:LCTONWCANYUPML-UHFFFAOYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1272,8 +1294,10 @@ "4-MSOB", "Wikidata:Q27106757", "ChEBI:5405", - "ChEBI:5405", - "InChI:WJMGSLJQEIYHOF-URYVQPGZSA-M" + "InChI:WJMGSLJQEIYHOF-URYVQPGZSA-M", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1313,7 +1337,8 @@ "CompactIdentifier:knapsack:C00007655", "A2", "Wikidata:Q23449332", - "InChI:CVAUKYVPQCYVDV-IPDRLXFSSA-O" + "InChI:CVAUKYVPQCYVDV-IPDRLXFSSA-O", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1393,8 +1418,11 @@ "CompactIdentifier:hmdb:HMDB0032538", "Triethanolamine", "ChEBI:28621", - "ChEBI:28621", - "InChI:GSEJCLTVZPLZKY-UHFFFAOYSA-N" + "InChI:GSEJCLTVZPLZKY-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1434,8 +1462,11 @@ "CompactIdentifier:hmdb:HMDB0000687", "Leucine", "ChEBI:15603", - "ChEBI:15603", - "InChI:ROHFNLRQFUQHCH-YFKPBYRVSA-N" + "InChI:ROHFNLRQFUQHCH-YFKPBYRVSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1469,7 +1500,6 @@ 0.5 ] }, - "id": "f1b08", "isAttachedTo": "a4155", "orientation": [ 1, @@ -1489,7 +1519,6 @@ 0.5 ] }, - "id": "d0842", "isAttachedTo": "af64a", "orientation": [ 1, @@ -1530,7 +1559,6 @@ 0.5 ] }, - "id": "eda4e", "isAttachedTo": "a21b1", "orientation": [ 1, @@ -1550,7 +1578,6 @@ 0.5 ] }, - "id": "a299a", "isAttachedTo": "e6df8", "orientation": [ 1, @@ -1596,7 +1623,8 @@ "CompactIdentifier:knapsack:C00005368", "F23", "Wikidata:Q23417673", - "InChI:PZZRDJXEMZMZFD-SQIUQIIDSA-N" + "InChI:PZZRDJXEMZMZFD-SQIUQIIDSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1636,8 +1664,11 @@ "CompactIdentifier:hmdb:HMDB0005826", "Galactinol", "ChEBI:17505", - "ChEBI:17505", - "InChI:VCWMRQDBPZKXKG-DXNLKLAMSA-N" + "InChI:VCWMRQDBPZKXKG-DXNLKLAMSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1671,7 +1702,6 @@ 1 ] }, - "id": "de069", "isAttachedTo": "bfe48", "orientation": [ 0, @@ -1691,7 +1721,6 @@ 0 ] }, - "id": "feaf8", "isAttachedTo": "b329c", "orientation": [ 0, @@ -1737,8 +1766,11 @@ "CompactIdentifier:hmdb:HMDB0000122", "Glucose", "ChEBI:15903", - "ChEBI:15903", - "InChI:WQZGKKKJIJFFOK-VFUOTHLCSA-N" + "InChI:WQZGKKKJIJFFOK-VFUOTHLCSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1778,8 +1810,11 @@ "CompactIdentifier:hmdb:HMDB0000098", "Xylose", "ChEBI:53455", - "ChEBI:53455", - "InChI:SRBFZHDQGSBBOR-IOVATXLUSA-N" + "InChI:SRBFZHDQGSBBOR-IOVATXLUSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1813,7 +1848,6 @@ 1 ] }, - "id": "ee424", "isAttachedTo": "cd3ef", "orientation": [ 0, @@ -1833,7 +1867,6 @@ 0.5 ] }, - "id": "e8248", "isAttachedTo": "a5894", "orientation": [ 1, @@ -1880,8 +1913,11 @@ "CompactIdentifier:hmdb:HMDB0000806", "C14:0", "ChEBI:28875", - "ChEBI:28875", - "InChI:TUNFSRHWOTWDNC-UHFFFAOYSA-N" + "InChI:TUNFSRHWOTWDNC-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1915,7 +1951,6 @@ 0.5 ] }, - "id": "f0bf7", "isAttachedTo": "c9a79", "orientation": [ -1, @@ -1935,7 +1970,6 @@ 0.5 ] }, - "id": "cfeaf", "isAttachedTo": "a9dfd", "orientation": [ -1, @@ -1981,7 +2015,8 @@ "CompactIdentifier:knapsack:C00005525", "F28", "Wikidata:Q23049780", - "InChI:CQLRUIIRRZYHHS-BYXQHVMRSA-N" + "InChI:CQLRUIIRRZYHHS-BYXQHVMRSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2021,8 +2056,11 @@ "CompactIdentifier:hmdb:HMDB0000168", "Asparagine", "ChEBI:17196", - "ChEBI:17196", - "InChI:DCXYFEDJOCDNAF-REOHCLBHSA-N" + "InChI:DCXYFEDJOCDNAF-REOHCLBHSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2056,7 +2094,6 @@ 1 ] }, - "id": "fd86b", "isAttachedTo": "f0f6a", "orientation": [ 0, @@ -2076,7 +2113,6 @@ 0 ] }, - "id": "d2296", "isAttachedTo": "b28f4", "orientation": [ 0, @@ -2189,7 +2225,6 @@ 0.5 ] }, - "id": "ba6aa", "isAttachedTo": "c2faf", "orientation": [ 1, @@ -2209,7 +2244,6 @@ 0.5 ] }, - "id": "f8595", "isAttachedTo": "a21b1", "orientation": [ 1, @@ -2249,7 +2283,6 @@ 0 ] }, - "id": "e6213", "isAttachedTo": "e765c", "orientation": [ 0, @@ -2269,7 +2302,6 @@ 1 ] }, - "id": "ba8e1", "isAttachedTo": "fe08c", "orientation": [ 0, @@ -2309,7 +2341,6 @@ 0.5 ] }, - "id": "e5008", "isAttachedTo": "ef1f6", "orientation": [ -1, @@ -2329,7 +2360,6 @@ 0.5 ] }, - "id": "b02cb", "isAttachedTo": "c8fdf", "orientation": [ -1, @@ -2376,8 +2406,8 @@ "6-MSOH", "Wikidata:Q59571080", "ChEBI:136956", - "ChEBI:136956", - "InChI:OOGAQHVYHLPICD-DNDZILKHSA-N" + "InChI:OOGAQHVYHLPICD-DNDZILKHSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2411,7 +2441,6 @@ 0.5 ] }, - "id": "bfb69", "isAttachedTo": "eff60", "orientation": [ 1, @@ -2431,7 +2460,6 @@ 0.5 ] }, - "id": "c73b6", "isAttachedTo": "e8e9b", "orientation": [ 1, @@ -2478,8 +2506,11 @@ "CompactIdentifier:hmdb:HMDB0000807", "glycerate 3-phosphate", "ChEBI:17050", - "ChEBI:17050", - "InChI:OSJPPGNTCRNQQC-UHFFFAOYSA-N" + "InChI:OSJPPGNTCRNQQC-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2519,8 +2550,11 @@ "CompactIdentifier:hmdb:HMDB0000167", "Threonine", "ChEBI:16857", - "ChEBI:16857", - "InChI:AYFVYJQAPQTCCC-GBXIJSLDSA-N" + "InChI:AYFVYJQAPQTCCC-GBXIJSLDSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2560,8 +2594,11 @@ "CompactIdentifier:hmdb:HMDB0000125", "Glutathione", "ChEBI:16856", - "ChEBI:16856", - "InChI:RWSXRVCMGQZWBV-WDSKDSINSA-N" + "InChI:RWSXRVCMGQZWBV-WDSKDSINSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2595,7 +2632,6 @@ 0.5 ] }, - "id": "b92c3", "isAttachedTo": "f4462", "orientation": [ -1, @@ -2615,7 +2651,6 @@ 0.5 ] }, - "id": "bc92f", "isAttachedTo": "afb92", "orientation": [ -1, @@ -2655,7 +2690,6 @@ 0 ] }, - "id": "db68b", "isAttachedTo": "eadf2", "orientation": [ 0, @@ -2675,7 +2709,6 @@ 0.5 ] }, - "id": "bdde5", "isAttachedTo": "baf30", "orientation": [ 1, @@ -2722,8 +2755,11 @@ "CompactIdentifier:hmdb:HMDB0000827", "C18:0", "ChEBI:28842", - "ChEBI:28842", - "InChI:QIQXTHQIDYTFRH-UHFFFAOYSA-N" + "InChI:QIQXTHQIDYTFRH-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2757,7 +2793,6 @@ 0.5 ] }, - "id": "afa00", "isAttachedTo": "f4462", "orientation": [ -1, @@ -2777,7 +2812,6 @@ 0.5 ] }, - "id": "f47d2", "isAttachedTo": "e079b", "orientation": [ -1, @@ -2823,8 +2857,10 @@ "CompactIdentifier:hmdb:HMDB0000148", "Glutamic acid", "ChEBI:16015", - "ChEBI:16015", - "InChI:WHUUTDBJXJRKMK-VKHMYHEASA-N" + "InChI:WHUUTDBJXJRKMK-VKHMYHEASA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2840,9 +2876,6 @@ "comments": [ { "content": "Isorhamnetin 3-neohesperidoside-7-rhamnoside" - }, - { - "content": "Type your comment here" } ], "drawAs": "rect", @@ -2905,10 +2938,11 @@ "CompactIdentifier:kegg.compound:C08412", "3-MTP", "Wikidata:Q27106759", - "ChEBI:5407", "ChEBI:79326", "ChEBI:5407", - "InChI:ZCZCVJVUJGULMO-IIPHORNXSA-M" + "InChI:ZCZCVJVUJGULMO-IIPHORNXSA-M", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2942,7 +2976,6 @@ 0.5 ] }, - "id": "a5a2a", "isAttachedTo": "f596d", "orientation": [ -1, @@ -2962,7 +2995,6 @@ 0.5 ] }, - "id": "d49e2", "isAttachedTo": "cccf9", "orientation": [ -1, @@ -3003,7 +3035,6 @@ 0.5 ] }, - "id": "d9fa6", "isAttachedTo": "f596d", "orientation": [ -1, @@ -3023,7 +3054,6 @@ 0.5 ] }, - "id": "bb655", "isAttachedTo": "d95b3", "orientation": [ -1, @@ -3064,7 +3094,6 @@ 0 ] }, - "id": "b9b2c", "isAttachedTo": "e1d01", "orientation": [ 0, @@ -3084,7 +3113,6 @@ 1 ] }, - "id": "b9cbf", "isAttachedTo": "c313a", "orientation": [ 0, @@ -3130,8 +3158,11 @@ "CompactIdentifier:hmdb:HMDB0001488", "Nicotinic acid", "ChEBI:15940", - "ChEBI:15940", - "InChI:PVNIIMVLHYAWGP-UHFFFAOYSA-N" + "InChI:PVNIIMVLHYAWGP-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3165,7 +3196,6 @@ 0.5 ] }, - "id": "b2a22", "isAttachedTo": "ad654", "orientation": [ 1, @@ -3185,7 +3215,6 @@ 0.5 ] }, - "id": "da2d9", "isAttachedTo": "a9dfd", "orientation": [ 1, @@ -3232,8 +3261,11 @@ "CompactIdentifier:hmdb:HMDB0000943", "Threonic acid", "ChEBI:15908", - "ChEBI:15908", - "InChI:JPIJQSOTBSSVTP-STHAYSLISA-N" + "InChI:JPIJQSOTBSSVTP-STHAYSLISA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3273,8 +3305,11 @@ "CompactIdentifier:hmdb:HMDB0000169", "Mannose", "ChEBI:28729", - "ChEBI:28729", - "InChI:WQZGKKKJIJFFOK-PQMKYFCFSA-N" + "InChI:WQZGKKKJIJFFOK-PQMKYFCFSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3314,8 +3349,11 @@ "CompactIdentifier:hmdb:HMDB0002545", "Galacturonic acid", "ChEBI:47962", - "ChEBI:47962", - "InChI:IAJILQKETJEXLJ-RSJOWCBRSA-N" + "InChI:IAJILQKETJEXLJ-RSJOWCBRSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3349,7 +3387,6 @@ 0.5 ] }, - "id": "ec89e", "isAttachedTo": "c3643", "orientation": [ 1, @@ -3369,7 +3406,6 @@ 0.5 ] }, - "id": "fb737", "isAttachedTo": "fbcfa", "orientation": [ 1, @@ -3409,7 +3445,6 @@ 0.5 ] }, - "id": "c930f", "isAttachedTo": "bfe48", "orientation": [ 1, @@ -3429,7 +3464,6 @@ 0.5 ] }, - "id": "a7800", "isAttachedTo": "baae8", "orientation": [ 1, @@ -3469,7 +3503,6 @@ 0.5 ] }, - "id": "ffaf0", "isAttachedTo": "d6a79", "orientation": [ 1, @@ -3489,7 +3522,6 @@ 0.5 ] }, - "id": "c0dfa", "isAttachedTo": "d65f6", "orientation": [ 1, @@ -3536,8 +3568,11 @@ "CompactIdentifier:hmdb:HMDB0001058", "Fructose 1,6-bisphosphate", "ChEBI:28013", - "ChEBI:28013", - "InChI:RNBGYGVWRKECFJ-ARQDHWQXSA-N" + "InChI:RNBGYGVWRKECFJ-ARQDHWQXSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3577,8 +3612,11 @@ "CompactIdentifier:hmdb:HMDB0000139", "Glyceric acid", "ChEBI:32398", - "ChEBI:32398", - "InChI:RBNPOMFGQQGHHO-UWTATZPHSA-N" + "InChI:RBNPOMFGQQGHHO-UWTATZPHSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3612,7 +3650,6 @@ 0.5 ] }, - "id": "ae00e", "isAttachedTo": "fbcfa", "orientation": [ 1, @@ -3632,7 +3669,6 @@ 0.5 ] }, - "id": "d2b30", "isAttachedTo": "fedfb", "orientation": [ 1, @@ -3678,7 +3714,8 @@ "CompactIdentifier:knapsack:C00007656", "A4", "Wikidata:Q23464998", - "InChI:HKRACDHMWOGFKJ-BPVIEZTISA-O" + "InChI:HKRACDHMWOGFKJ-BPVIEZTISA-O", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3712,7 +3749,6 @@ 0.5 ] }, - "id": "ab18b", "isAttachedTo": "ababd", "orientation": [ 1, @@ -3732,7 +3768,6 @@ 0.5 ] }, - "id": "ae75b", "isAttachedTo": "cccf9", "orientation": [ 1, @@ -3772,7 +3807,6 @@ 0 ] }, - "id": "ade45", "isAttachedTo": "bc136", "orientation": [ 0, @@ -3792,7 +3826,6 @@ 1 ] }, - "id": "e7ae3", "isAttachedTo": "f75f0", "orientation": [ 0, @@ -3839,8 +3872,10 @@ "5-MSOP", "Wikidata:Q27106748", "ChEBI:5395", - "ChEBI:5395", - "InChI:HUCGRJSHMZWRQQ-PWGYDFSISA-N" + "InChI:HUCGRJSHMZWRQQ-PWGYDFSISA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3880,8 +3915,11 @@ "CompactIdentifier:hmdb:HMDB0000187", "Serine", "ChEBI:17115", - "ChEBI:17115", - "InChI:MTCFGRXMJLQNBG-REOHCLBHSA-N" + "InChI:MTCFGRXMJLQNBG-REOHCLBHSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3922,8 +3960,10 @@ "3-MSOP", "Wikidata:Q27106752", "ChEBI:5400", - "ChEBI:5400", - "InChI:OFKKQTQFWWIRBD-ZHVGPZTNSA-M" + "InChI:OFKKQTQFWWIRBD-ZHVGPZTNSA-M", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3963,8 +4003,11 @@ "CompactIdentifier:hmdb:HMDB0001401", "Glucose-6-phosphate", "ChEBI:4170", - "ChEBI:4170", - "InChI:NBSCHQHZLSJFNQ-GASJEMHNSA-N" + "InChI:NBSCHQHZLSJFNQ-GASJEMHNSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4004,8 +4047,11 @@ "CompactIdentifier:hmdb:HMDB0000193", "Isocitric acid", "ChEBI:30887", - "ChEBI:30887", - "InChI:ODBLHEXUDAPZAU-UHFFFAOYSA-N" + "InChI:ODBLHEXUDAPZAU-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4039,7 +4085,6 @@ 0.5 ] }, - "id": "b4f1b", "isAttachedTo": "ec6ff", "orientation": [ -1, @@ -4059,7 +4104,6 @@ 0.5 ] }, - "id": "b30b4", "isAttachedTo": "a296e", "orientation": [ -1, @@ -4105,8 +4149,10 @@ "CompactIdentifier:hmdb:HMDB0000213", "Myo-inositol 1-phosphate", "ChEBI:18297", - "ChEBI:18297", - "InChI:INAPMGSXUVUWAF-UOTPTPDRSA-N" + "InChI:INAPMGSXUVUWAF-UOTPTPDRSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4147,8 +4193,11 @@ "lysoPC", "Wikidata:Q27160591", "ChEBI:88697", - "ChEBI:88697", - "InChI:WKQNRCYKYCKESD-YVHLTTHBSA-N" + "InChI:WKQNRCYKYCKESD-YVHLTTHBSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4188,8 +4237,11 @@ "CompactIdentifier:hmdb:HMDB0000214", "Ornithine", "ChEBI:15729", - "ChEBI:15729", - "InChI:AHLPHDHHMVZTML-BYPYZUCNSA-N" + "InChI:AHLPHDHHMVZTML-BYPYZUCNSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4229,8 +4281,11 @@ "CompactIdentifier:hmdb:HMDB0002869", "Campesterol", "ChEBI:28623", - "ChEBI:28623", - "InChI:SGNBVLSWZMBQTH-PODYLUTMSA-N" + "InChI:SGNBVLSWZMBQTH-PODYLUTMSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4271,8 +4326,11 @@ "Sucrose", "Wikidata:Q4027534", "ChEBI:17992", - "ChEBI:17992", - "InChI:CZMRCDWAGMRECN-UGDNZRGBSA-N" + "InChI:CZMRCDWAGMRECN-UGDNZRGBSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4312,8 +4370,11 @@ "CompactIdentifier:hmdb:HMDB0000220", "C16:0", "ChEBI:15756", - "ChEBI:15756", - "InChI:IPCSVZSSVZVIGE-UHFFFAOYSA-N" + "InChI:IPCSVZSSVZVIGE-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4353,8 +4414,11 @@ "CompactIdentifier:hmdb:HMDB0000094", "Citric acid", "ChEBI:30769", - "ChEBI:30769", - "InChI:KRKNYBCHXYNGOX-UHFFFAOYSA-N" + "InChI:KRKNYBCHXYNGOX-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4394,8 +4458,10 @@ "CompactIdentifier:hmdb:HMDB0000044", "Ascorbic acid", "ChEBI:29073", - "ChEBI:29073", - "InChI:CIWBSHSKHKDKBQ-JLAZNSOCSA-N" + "InChI:CIWBSHSKHKDKBQ-JLAZNSOCSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4435,8 +4501,11 @@ "CompactIdentifier:hmdb:HMDB0000742", "Homocysteine", "ChEBI:17588", - "ChEBI:17588", - "InChI:FFFHZYDWPBMWHY-VKHMYHEASA-N" + "InChI:FFFHZYDWPBMWHY-VKHMYHEASA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4476,8 +4545,11 @@ "CompactIdentifier:hmdb:HMDB0000134", "Fumaric acid", "ChEBI:18012", - "ChEBI:18012", - "InChI:VZCYOOQTPOCHFL-OWOJBTEDSA-N" + "InChI:VZCYOOQTPOCHFL-OWOJBTEDSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4517,8 +4589,11 @@ "CompactIdentifier:hmdb:HMDB0000123", "Glycine", "ChEBI:15428", - "ChEBI:15428", - "InChI:DHMQDGOQFOQNFH-UHFFFAOYSA-N" + "InChI:DHMQDGOQFOQNFH-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4552,7 +4627,6 @@ 0.5 ] }, - "id": "af78d", "isAttachedTo": "c6818", "orientation": [ 1, @@ -4572,7 +4646,6 @@ 0 ] }, - "id": "c9a57", "isAttachedTo": "b502b", "orientation": [ 0, @@ -4618,8 +4691,11 @@ "CompactIdentifier:hmdb:HMDB0000937", "Stigmasterol", "ChEBI:28824", - "ChEBI:28824", - "InChI:HCXVJBMSMIARIN-PHZDYDNGSA-N" + "InChI:HCXVJBMSMIARIN-PHZDYDNGSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4653,7 +4729,6 @@ 0.5 ] }, - "id": "da63c", "isAttachedTo": "d054f", "orientation": [ -1, @@ -4673,7 +4748,6 @@ 0.5 ] }, - "id": "e0c52", "isAttachedTo": "b67c4", "orientation": [ -1, @@ -4713,7 +4787,6 @@ 0.5 ] }, - "id": "c18d2", "isAttachedTo": "a42b5", "orientation": [ 1, @@ -4733,7 +4806,6 @@ 0.5 ] }, - "id": "d1fa1", "isAttachedTo": "e1d01", "orientation": [ 1, @@ -4780,8 +4852,10 @@ "7-MTH", "Wikidata:Q27154957", "ChEBI:80988", - "ChEBI:80988", - "InChI:SJHVRBSHKTUXLG-LFHLZQBKSA-N" + "InChI:SJHVRBSHKTUXLG-LFHLZQBKSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4815,7 +4889,6 @@ 0.5 ] }, - "id": "b2bfc", "isAttachedTo": "a5c20", "orientation": [ 1, @@ -4835,7 +4908,6 @@ 0.5 ] }, - "id": "ba496", "isAttachedTo": "f2ec0", "orientation": [ 1, @@ -4881,8 +4953,11 @@ "CompactIdentifier:hmdb:HMDB0000159", "Phenylalanine", "ChEBI:17295", - "ChEBI:17295", - "InChI:COLNVLDHVKWLRT-QMMMGPOBSA-N" + "InChI:COLNVLDHVKWLRT-QMMMGPOBSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4922,8 +4997,10 @@ "CompactIdentifier:hmdb:HMDB0029942", "Arabinose", "ChEBI:46996", - "ChEBI:46996", - "InChI:SRBFZHDQGSBBOR-SQOUGZDYSA-N" + "InChI:SRBFZHDQGSBBOR-SQOUGZDYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4963,7 +5040,9 @@ "CompactIdentifier:chemspider:7825685", "PE", "Wikidata:Q42403336", - "InChI:WIHSZOXPODIZSW-YTWBPVBXSA-N" + "InChI:WIHSZOXPODIZSW-YTWBPVBXSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5004,8 +5083,9 @@ "7-MSOH", "Wikidata:Q59571113", "ChEBI:132553", - "ChEBI:132553", - "InChI:LQZALQLZOQQFGM-MMLSCURJSA-N" + "InChI:LQZALQLZOQQFGM-MMLSCURJSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5046,8 +5126,11 @@ "Glycerol 2-phosphate", "Wikidata:Q21099098", "ChEBI:17270", - "ChEBI:17270", - "InChI:DHCLVCXQIBBOPH-UHFFFAOYSA-N" + "InChI:DHCLVCXQIBBOPH-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5087,8 +5170,11 @@ "CompactIdentifier:hmdb:HMDB0003070", "Shikimic acid", "ChEBI:16119", - "ChEBI:16119", - "InChI:JXOHGGNKMLTUBP-HSUXUTPPSA-N" + "InChI:JXOHGGNKMLTUBP-HSUXUTPPSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5161,8 +5247,11 @@ "CompactIdentifier:hmdb:HMDB0000660", "Fructose", "ChEBI:28645", - "ChEBI:28645", - "InChI:RFSUNEUAIZKAJO-ARQDHWQXSA-N" + "InChI:RFSUNEUAIZKAJO-ARQDHWQXSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5202,8 +5291,11 @@ "CompactIdentifier:hmdb:HMDB0000162", "Proline", "ChEBI:17203", - "ChEBI:17203", - "InChI:ONIBWKKTOPOVIA-BYPYZUCNSA-N" + "InChI:ONIBWKKTOPOVIA-BYPYZUCNSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5243,7 +5335,8 @@ "CompactIdentifier:knapsack:C00005174", "F19", "Wikidata:Q23058968", - "InChI:JIGYKOJSDSJFFW-DBFSWMNWSA-N" + "InChI:JIGYKOJSDSJFFW-DBFSWMNWSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5277,7 +5370,6 @@ 1 ] }, - "id": "cd8b4", "isAttachedTo": "a183f", "orientation": [ 0, @@ -5297,7 +5389,6 @@ 0 ] }, - "id": "f5ff1", "isAttachedTo": "b28f4", "orientation": [ 0, @@ -5343,7 +5434,8 @@ "CompactIdentifier:knapsack:C00005558", "F15", "Wikidata:Q23049771", - "InChI:UWQOGHWNWIJMNI-SZBCTZJWSA-N" + "InChI:UWQOGHWNWIJMNI-SZBCTZJWSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5377,7 +5469,6 @@ 0 ] }, - "id": "a81d0", "isAttachedTo": "d243e", "orientation": [ 0, @@ -5397,7 +5488,6 @@ 0.5 ] }, - "id": "f1438", "isAttachedTo": "baf30", "orientation": [ 1, @@ -5448,8 +5538,12 @@ "F1", "Wikidata:Q6345965", "ChEBI:68883", - "ChEBI:68883", - "InChI:PUPKKEQDLNREIM-QNSQPKOQSA-N" + "InChI:PUPKKEQDLNREIM-QNSQPKOQSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5483,7 +5577,6 @@ 0 ] }, - "id": "aa8e2", "isAttachedTo": "d6a79", "orientation": [ 0, @@ -5503,7 +5596,6 @@ 0.5 ] }, - "id": "e33fe", "isAttachedTo": "bfe2d", "orientation": [ 1, @@ -5550,7 +5642,9 @@ "F5", "Wikidata:Q23418551", "ChEBI:133245", - "InChI:GXLQUHPXGLZNGE-BRHFUIPOSA-N" + "InChI:GXLQUHPXGLZNGE-BRHFUIPOSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5590,8 +5684,11 @@ "CompactIdentifier:hmdb:HMDB0001388", "C18:3", "ChEBI:27432", - "ChEBI:27432", - "InChI:DTOSIQBPPRVQHS-PDBXOOCHSA-N" + "InChI:DTOSIQBPPRVQHS-PDBXOOCHSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5625,7 +5722,6 @@ 1 ] }, - "id": "bdc02", "isAttachedTo": "e660e", "orientation": [ 0, @@ -5645,7 +5741,6 @@ 0 ] }, - "id": "e79de", "isAttachedTo": "ccc7f", "orientation": [ 0, @@ -5691,7 +5786,8 @@ "CompactIdentifier:knapsack:C00005557", "F14", "Wikidata:Q45410367", - "InChI:NEJKEXUJCSYMCC-AKTJOMHVSA-N" + "InChI:NEJKEXUJCSYMCC-AKTJOMHVSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5731,8 +5827,11 @@ "CompactIdentifier:hmdb:HMDB0000283", "Ribose", "ChEBI:47013", - "ChEBI:47013", - "InChI:HMFHBZSHGGEWLO-SOOFDHNKSA-N" + "InChI:HMFHBZSHGGEWLO-SOOFDHNKSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5772,8 +5871,11 @@ "CompactIdentifier:hmdb:HMDB0000208", "2-Oxo-glutaric acid", "ChEBI:30915", - "ChEBI:30915", - "InChI:KPGXRSRHYNQIFN-UHFFFAOYSA-N" + "InChI:KPGXRSRHYNQIFN-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5789,9 +5891,6 @@ "comments": [ { "content": "FL5FACGS0030" - }, - { - "content": "Type your comment here" } ], "drawAs": "rect", @@ -5848,7 +5947,6 @@ 0.5 ] }, - "id": "de3bc", "isAttachedTo": "f596d", "orientation": [ -1, @@ -5868,7 +5966,6 @@ 0.5 ] }, - "id": "f0e97", "isAttachedTo": "f2ec0", "orientation": [ -1, @@ -5909,7 +6006,6 @@ 0 ] }, - "id": "e5f44", "isAttachedTo": "d476b", "orientation": [ 0, @@ -5929,7 +6025,6 @@ 1 ] }, - "id": "bc1b4", "isAttachedTo": "a771e", "orientation": [ 0, @@ -5975,8 +6070,11 @@ "CompactIdentifier:hmdb:HMDB0005794", "Quercetin", "ChEBI:16243", - "ChEBI:16243", - "InChI:REFJWTPEDVJJIY-UHFFFAOYSA-N" + "InChI:REFJWTPEDVJJIY-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6016,8 +6114,11 @@ "CompactIdentifier:hmdb:HMDB0000149", "Ethanolamine", "ChEBI:16000", - "ChEBI:16000", - "InChI:HZAXFHJVJLSVMW-UHFFFAOYSA-N" + "InChI:HZAXFHJVJLSVMW-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6051,7 +6152,6 @@ 1 ] }, - "id": "af4ea", "isAttachedTo": "e660e", "orientation": [ 0, @@ -6071,7 +6171,6 @@ 0.5 ] }, - "id": "f307e", "isAttachedTo": "bc576", "orientation": [ -1, @@ -6111,7 +6210,6 @@ 0.5 ] }, - "id": "eff31", "isAttachedTo": "f4462", "orientation": [ -1, @@ -6131,7 +6229,6 @@ 0.5 ] }, - "id": "e9cff", "isAttachedTo": "f50f3", "orientation": [ -1, @@ -6177,8 +6274,11 @@ "CompactIdentifier:hmdb:HMDB0000661", "Glutaric acid", "ChEBI:17859", - "ChEBI:17859", - "InChI:JFCQEDHGNNZCLN-UHFFFAOYSA-N" + "InChI:JFCQEDHGNNZCLN-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6212,7 +6312,6 @@ 0.5 ] }, - "id": "d2e5d", "isAttachedTo": "a4155", "orientation": [ 1, @@ -6232,7 +6331,6 @@ 0.5 ] }, - "id": "a426d", "isAttachedTo": "a372c", "orientation": [ 1, @@ -6279,8 +6377,11 @@ "CompactIdentifier:hmdb:HMDB0000306", "Tyramine", "ChEBI:15760", - "ChEBI:15760", - "InChI:DZGWFCGJZKJUFP-UHFFFAOYSA-N" + "InChI:DZGWFCGJZKJUFP-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6314,7 +6415,6 @@ 1 ] }, - "id": "a1520", "isAttachedTo": "e079b", "orientation": [ 0, @@ -6334,7 +6434,6 @@ 0 ] }, - "id": "b818d", "isAttachedTo": "f50f3", "orientation": [ 0, @@ -6413,8 +6512,11 @@ "CompactIdentifier:hmdb:HMDB0000303", "Tryptamine", "ChEBI:16765", - "ChEBI:16765", - "InChI:APJYDQYYACXCRM-UHFFFAOYSA-N" + "InChI:APJYDQYYACXCRM-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6454,8 +6556,11 @@ "CompactIdentifier:hmdb:HMDB0005801", "Kaempferol", "ChEBI:28499", - "ChEBI:28499", - "InChI:IYRMWMYZSQPJKC-UHFFFAOYSA-N" + "InChI:IYRMWMYZSQPJKC-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6495,7 +6600,9 @@ "CompactIdentifier:chemspider:8593139", "PG", "Wikidata:Q42403337", - "InChI:MPTSWFXLMIATGU-YTWBPVBXSA-N" + "InChI:MPTSWFXLMIATGU-YTWBPVBXSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6536,8 +6643,11 @@ "TAG", "Wikidata:Q27145591", "ChEBI:75845", - "ChEBI:75845", - "InChI:UBEIMDKGOYBUKT-FLIQGJDUSA-N" + "InChI:UBEIMDKGOYBUKT-FLIQGJDUSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6571,7 +6681,6 @@ 0.5 ] }, - "id": "b7386", "isAttachedTo": "f1641", "orientation": [ 1, @@ -6591,7 +6700,6 @@ 0.5 ] }, - "id": "cf986", "isAttachedTo": "b69e5", "orientation": [ 1, @@ -6631,7 +6739,6 @@ 0 ] }, - "id": "b5c43", "isAttachedTo": "f596d", "orientation": [ 0, @@ -6651,7 +6758,6 @@ 1 ] }, - "id": "fe026", "isAttachedTo": "bf03b", "orientation": [ 0, @@ -6770,8 +6876,11 @@ "CompactIdentifier:hmdb:HMDB0000177", "Histidine", "ChEBI:15971", - "ChEBI:15971", - "InChI:HNDVDQJCIGZPNO-YFKPBYRVSA-N" + "InChI:HNDVDQJCIGZPNO-YFKPBYRVSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6812,11 +6921,14 @@ "4-MTB", "Wikidata:Q27106756", "ChEBI:79325", - "ChEBI:79325", - "ChEBI:5404", "ChEBI:5404", "InChI:GKUMMDFLKGFCKH-AHMUMSBHSA-N", - "InChI:GKUMMDFLKGFCKH-AHMUMSBHSA-M" + "InChI:GKUMMDFLKGFCKH-AHMUMSBHSA-M", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6850,7 +6962,6 @@ 0.5 ] }, - "id": "ddcdd", "isAttachedTo": "a183f", "orientation": [ 1, @@ -6870,7 +6981,6 @@ 0.5 ] }, - "id": "c1826", "isAttachedTo": "a9dfd", "orientation": [ 1, @@ -6917,8 +7027,11 @@ "CompactIdentifier:hmdb:HMDB0000254", "Succinic acid", "ChEBI:15741", - "ChEBI:15741", - "InChI:KDYFGRWQOYBRFD-UHFFFAOYSA-N" + "InChI:KDYFGRWQOYBRFD-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6952,7 +7065,6 @@ 1 ] }, - "id": "edcc3", "isAttachedTo": "e1d01", "orientation": [ 0, @@ -6972,7 +7084,6 @@ 0 ] }, - "id": "fe1d4", "isAttachedTo": "d3ea8", "orientation": [ 0, @@ -7019,8 +7130,10 @@ "F7", "Wikidata:Q23418549", "ChEBI:133244", - "ChEBI:133244", - "InChI:MCTZMXCUYPDYNE-AHHFARBASA-N" + "InChI:MCTZMXCUYPDYNE-AHHFARBASA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7060,8 +7173,11 @@ "CompactIdentifier:hmdb:HMDB0003072", "Quinic acid", "ChEBI:17521", - "ChEBI:17521", - "InChI:AAWZDTNXLSGCEK-WYWMIBKRSA-N" + "InChI:AAWZDTNXLSGCEK-WYWMIBKRSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7101,8 +7217,11 @@ "CompactIdentifier:hmdb:HMDB0000625", "Gluconic acid", "ChEBI:33198", - "ChEBI:33198", - "InChI:RGHNJXZEOKUKBD-SQOUGZDYSA-N" + "InChI:RGHNJXZEOKUKBD-SQOUGZDYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7136,7 +7255,6 @@ 0.5 ] }, - "id": "feb89", "isAttachedTo": "c2faf", "orientation": [ 1, @@ -7156,7 +7274,6 @@ 0.5 ] }, - "id": "db468", "isAttachedTo": "dc60f", "orientation": [ 1, @@ -7202,8 +7319,11 @@ "CompactIdentifier:hmdb:HMDB0000719", "Homoserine", "ChEBI:15699", - "ChEBI:15699", - "InChI:UKAUYVFTDYCKQA-VKHMYHEASA-N" + "InChI:UKAUYVFTDYCKQA-VKHMYHEASA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7237,7 +7357,6 @@ 0 ] }, - "id": "f5951", "isAttachedTo": "fbcfa", "orientation": [ 0, @@ -7257,7 +7376,6 @@ 1 ] }, - "id": "b4e5d", "isAttachedTo": "cb441", "orientation": [ 0, @@ -7297,7 +7415,6 @@ 0.5 ] }, - "id": "fe194", "isAttachedTo": "c63fb", "orientation": [ 1, @@ -7317,7 +7434,6 @@ 0.5 ] }, - "id": "a025d", "isAttachedTo": "baf30", "orientation": [ 1, @@ -7365,8 +7481,12 @@ "F24", "Wikidata:Q1649777", "ChEBI:17558", - "ChEBI:17558", - "InChI:OXGUCUVFOIWWQJ-HQBVPOQASA-N" + "InChI:OXGUCUVFOIWWQJ-HQBVPOQASA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7406,8 +7526,11 @@ "CompactIdentifier:hmdb:HMDB0000975", "Trehalose", "ChEBI:16551", - "ChEBI:16551", - "InChI:HDTRYLNUVZCQOY-LIZSDCNHSA-N" + "InChI:HDTRYLNUVZCQOY-LIZSDCNHSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7441,7 +7564,6 @@ 0.5 ] }, - "id": "d1ff4", "isAttachedTo": "cb6df", "orientation": [ 1, @@ -7461,7 +7583,6 @@ 0.5 ] }, - "id": "c8f01", "isAttachedTo": "c8fdf", "orientation": [ 1, @@ -7507,7 +7628,9 @@ "CompactIdentifier:chemspider:140119", "SQDG", "Wikidata:Q42403295", - "InChI:RVUUQPKXGDTQPG-PINKXYAGSA-N" + "InChI:RVUUQPKXGDTQPG-PINKXYAGSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7547,8 +7670,11 @@ "CompactIdentifier:hmdb:HMDB0000300", "Uracil", "ChEBI:17568", - "ChEBI:17568", - "InChI:ISAKRJDGNUQOIC-UHFFFAOYSA-N" + "InChI:ISAKRJDGNUQOIC-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7582,7 +7708,6 @@ 0.5 ] }, - "id": "cc1b2", "isAttachedTo": "e660e", "orientation": [ -1, @@ -7602,7 +7727,6 @@ 0.5 ] }, - "id": "e1043", "isAttachedTo": "d65f6", "orientation": [ -1, @@ -7642,7 +7766,6 @@ 0.5 ] }, - "id": "af333", "isAttachedTo": "f9ba1", "orientation": [ 1, @@ -7662,7 +7785,6 @@ 0.5 ] }, - "id": "a15e9", "isAttachedTo": "caaa5", "orientation": [ 1, @@ -7702,7 +7824,6 @@ 1 ] }, - "id": "ecf71", "isAttachedTo": "c9a79", "orientation": [ 0, @@ -7722,7 +7843,6 @@ 0 ] }, - "id": "c9e6d", "isAttachedTo": "acf85", "orientation": [ 0, @@ -7768,8 +7888,11 @@ "CompactIdentifier:hmdb:HMDB0003338", "Hydroxylamine", "ChEBI:15429", - "ChEBI:15429", - "InChI:AVXURJPOCDRRFD-UHFFFAOYSA-N" + "InChI:AVXURJPOCDRRFD-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7809,8 +7932,11 @@ "CompactIdentifier:hmdb:HMDB0000517", "Arginine", "ChEBI:16467", - "ChEBI:16467", - "InChI:ODKSFYDXXFIFQN-BYPYZUCNSA-N" + "InChI:ODKSFYDXXFIFQN-BYPYZUCNSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7844,7 +7970,6 @@ 0.5 ] }, - "id": "ab7e3", "isAttachedTo": "e079b", "orientation": [ -1, @@ -7864,7 +7989,6 @@ 0.5 ] }, - "id": "bc751", "isAttachedTo": "d054f", "orientation": [ -1, @@ -7910,7 +8034,8 @@ "CompactIdentifier:knapsack:C00005470", "F8", "Wikidata:Q23418553", - "InChI:WLPJMCCYDZFCBL-JJSAVOBRSA-N" + "InChI:WLPJMCCYDZFCBL-JJSAVOBRSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7950,7 +8075,8 @@ "CompactIdentifier:knapsack:C00005551", "F29", "Wikidata:Q23049759", - "InChI:UIXIEXAWTSBGCB-PLZSGXCYSA-N" + "InChI:UIXIEXAWTSBGCB-PLZSGXCYSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7984,7 +8110,6 @@ 0.5 ] }, - "id": "a74c5", "isAttachedTo": "a4155", "orientation": [ 1, @@ -8004,7 +8129,6 @@ 0.5 ] }, - "id": "a4d65", "isAttachedTo": "fe878", "orientation": [ 1, @@ -8045,7 +8169,6 @@ 0 ] }, - "id": "c9223", "isAttachedTo": "a42b5", "orientation": [ 0, @@ -8065,7 +8188,6 @@ 1 ] }, - "id": "b1684", "isAttachedTo": "ff8b6", "orientation": [ 0, @@ -8111,8 +8233,11 @@ "CompactIdentifier:hmdb:HMDB0000056", "Beta-Alanine", "ChEBI:16958", - "ChEBI:16958", - "InChI:UCMIRNVEIXFBKS-UHFFFAOYSA-N" + "InChI:UCMIRNVEIXFBKS-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8152,11 +8277,15 @@ "CompactIdentifier:kegg.compound:C08401", "5-MTP", "Wikidata:Q27106749", - "ChEBI:5396", - "ChEBI:5396", "ChEBI:79324", + "ChEBI:5396", "InChI:MEFPHTVXBPLRLX-CBEPRAPJSA-M", - "InChI:MEFPHTVXBPLRLX-ZMHPAJMFSA-N" + "InChI:MEFPHTVXBPLRLX-ZMHPAJMFSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8190,7 +8319,6 @@ 0.5 ] }, - "id": "da30f", "isAttachedTo": "b9080", "orientation": [ -1, @@ -8210,7 +8338,6 @@ 0.5 ] }, - "id": "a263c", "isAttachedTo": "b262a", "orientation": [ -1, @@ -8250,7 +8377,6 @@ 0 ] }, - "id": "cf582", "isAttachedTo": "bf03b", "orientation": [ 0, @@ -8270,7 +8396,6 @@ 1 ] }, - "id": "fbfb2", "isAttachedTo": "d054f", "orientation": [ 0, @@ -8311,7 +8436,6 @@ 0.5 ] }, - "id": "d206e", "isAttachedTo": "b82cb", "orientation": [ -1, @@ -8331,7 +8455,6 @@ 0.5 ] }, - "id": "f83d3", "isAttachedTo": "b9080", "orientation": [ -1, @@ -8371,7 +8494,6 @@ 0.5 ] }, - "id": "bfdee", "isAttachedTo": "c329d", "orientation": [ 1, @@ -8391,7 +8513,6 @@ 0.5 ] }, - "id": "a417b", "isAttachedTo": "c1c60", "orientation": [ 1, @@ -8431,7 +8552,6 @@ 0.5 ] }, - "id": "a3e8e", "isAttachedTo": "e1d01", "orientation": [ 1, @@ -8451,7 +8571,6 @@ 0.5 ] }, - "id": "c2091", "isAttachedTo": "fa165", "orientation": [ 1, @@ -8497,8 +8616,11 @@ "CompactIdentifier:hmdb:HMDB0001964", "Caffeic acid", "ChEBI:16433", - "ChEBI:16433", - "InChI:QAIPRVGONGVQAS-DUXPYHPUSA-N" + "InChI:QAIPRVGONGVQAS-DUXPYHPUSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8532,7 +8654,6 @@ 0.5 ] }, - "id": "f7094", "isAttachedTo": "f596d", "orientation": [ -1, @@ -8552,7 +8673,6 @@ 0.5 ] }, - "id": "caa83", "isAttachedTo": "b5b69", "orientation": [ -1, @@ -8599,7 +8719,8 @@ "CompactIdentifier:knapsack:C00005559", "F30", "Wikidata:Q23049774", - "InChI:UNMZJSVCTCKOEC-QPPFPMOSSA-N" + "InChI:UNMZJSVCTCKOEC-QPPFPMOSSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8639,8 +8760,11 @@ "CompactIdentifier:hmdb:HMDB0001185", "S-Adenosylmethionine", "ChEBI:15414", - "ChEBI:15414", - "InChI:MEFKEPWMEQBLKI-AIRLBKTGSA-O" + "InChI:MEFKEPWMEQBLKI-AIRLBKTGSA-O", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8680,7 +8804,8 @@ "CompactIdentifier:knapsack:C00005237", "F3", "Wikidata:Q23417468", - "InChI:DDELFAUOHDSZJL-JEHSZLPQSA-N" + "InChI:DDELFAUOHDSZJL-JEHSZLPQSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8720,8 +8845,11 @@ "CompactIdentifier:hmdb:HMDB0002019", "Phytol", "ChEBI:17327", - "ChEBI:17327", - "InChI:BOTWFXYSPFMFNR-PYDDKJGSSA-N" + "InChI:BOTWFXYSPFMFNR-PYDDKJGSSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8762,8 +8890,10 @@ "6-MTH", "Wikidata:Q27154956", "ChEBI:80987", - "ChEBI:80987", - "InChI:ZAKICGFSIJSCSF-LPUQOGTASA-N" + "InChI:ZAKICGFSIJSCSF-LPUQOGTASA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8803,8 +8933,11 @@ "CompactIdentifier:hmdb:HMDB0000182", "Lysine", "ChEBI:18019", - "ChEBI:18019", - "InChI:KDXKERNSBIXSRK-YFKPBYRVSA-N" + "InChI:KDXKERNSBIXSRK-YFKPBYRVSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8838,7 +8971,6 @@ 0 ] }, - "id": "e7393", "isAttachedTo": "e660e", "orientation": [ 0, @@ -8858,7 +8990,6 @@ 1 ] }, - "id": "fcd04", "isAttachedTo": "b502b", "orientation": [ 0, @@ -8898,7 +9029,6 @@ 0.5 ] }, - "id": "a0bc2", "isAttachedTo": "eff60", "orientation": [ 1, @@ -8918,7 +9048,6 @@ 0.5 ] }, - "id": "b5eae", "isAttachedTo": "c065b", "orientation": [ 1, @@ -8965,8 +9094,11 @@ "CompactIdentifier:hmdb:HMDB0000574", "Cysteine", "ChEBI:17561", - "ChEBI:17561", - "InChI:XUJNEKJLAYXESH-REOHCLBHSA-N" + "InChI:XUJNEKJLAYXESH-REOHCLBHSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9007,7 +9139,8 @@ "DAG", "Wikidata:Q161466", "ChEBI:18035", - "ChEBI:18035" + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9041,7 +9174,6 @@ 1 ] }, - "id": "d9f32", "isAttachedTo": "baae8", "orientation": [ 0, @@ -9061,7 +9193,6 @@ 0 ] }, - "id": "d3ec5", "isAttachedTo": "e1686", "orientation": [ 0, @@ -9141,7 +9272,6 @@ 0 ] }, - "id": "b47ee", "isAttachedTo": "fe08c", "orientation": [ 0, @@ -9161,7 +9291,6 @@ 1 ] }, - "id": "c7595", "isAttachedTo": "bc576", "orientation": [ 0, @@ -9201,7 +9330,6 @@ 0.5 ] }, - "id": "b3d25", "isAttachedTo": "eb629", "orientation": [ 1, @@ -9221,7 +9349,6 @@ 0.5 ] }, - "id": "be80f", "isAttachedTo": "cf5a1", "orientation": [ 1, @@ -9267,8 +9394,11 @@ "CompactIdentifier:hmdb:HMDB0000807", "3-Phosphoglyceric acid", "ChEBI:17050", - "ChEBI:17050", - "InChI:OSJPPGNTCRNQQC-UHFFFAOYSA-N" + "InChI:OSJPPGNTCRNQQC-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9302,7 +9432,6 @@ 1 ] }, - "id": "b3974", "isAttachedTo": "e1686", "orientation": [ 0, @@ -9322,7 +9451,6 @@ 0 ] }, - "id": "f8baa", "isAttachedTo": "a5b89", "orientation": [ 0, @@ -9368,8 +9496,11 @@ "CompactIdentifier:hmdb:HMDB0000641", "Glutamine", "ChEBI:18050", - "ChEBI:18050", - "InChI:ZDXPYRJPNDTMRX-VKHMYHEASA-N" + "InChI:ZDXPYRJPNDTMRX-VKHMYHEASA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9409,8 +9540,11 @@ "CompactIdentifier:hmdb:HMDB0001895", "Salicylic acid", "ChEBI:16914", - "ChEBI:16914", - "InChI:YGSDEFSMJLZEOE-UHFFFAOYSA-N" + "InChI:YGSDEFSMJLZEOE-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9444,7 +9578,6 @@ 0.5 ] }, - "id": "fa762", "isAttachedTo": "e49ed", "orientation": [ 1, @@ -9464,7 +9597,6 @@ 0.5 ] }, - "id": "d33b3", "isAttachedTo": "bc136", "orientation": [ 1, @@ -9504,7 +9636,6 @@ 0.5 ] }, - "id": "b878e", "isAttachedTo": "a4155", "orientation": [ 1, @@ -9524,7 +9655,6 @@ 0.5 ] }, - "id": "b6565", "isAttachedTo": "be352", "orientation": [ 1, @@ -9571,8 +9701,11 @@ "CompactIdentifier:hmdb:HMDB0001257", "Spermidine", "ChEBI:16610", - "ChEBI:16610", - "InChI:ATHGHQPFGPMSJY-UHFFFAOYSA-N" + "InChI:ATHGHQPFGPMSJY-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9591,9 +9724,6 @@ "comments": [ { "content": "Cyanidin 3-sambubioside-5-glucoside" - }, - { - "content": "Type your comment here" } ], "drawAs": "rect", @@ -9623,7 +9753,9 @@ "CompactIdentifier:kegg.compound:C20493", "A1", "Wikidata:Q23419061", - "InChI:OLBLWNPOURNBCY-QFEPKXLGSA-O" + "InChI:OLBLWNPOURNBCY-QFEPKXLGSA-O", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9663,8 +9795,11 @@ "CompactIdentifier:hmdb:HMDB0000072", "cis-Aconitic acid", "ChEBI:32805", - "ChEBI:32805", - "InChI:GTZCVFVGUGFEME-IWQZZHSRSA-N" + "InChI:GTZCVFVGUGFEME-IWQZZHSRSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9698,7 +9833,6 @@ 1 ] }, - "id": "cd815", "isAttachedTo": "bef70", "orientation": [ 0, @@ -9718,7 +9852,6 @@ 0 ] }, - "id": "f80fe", "isAttachedTo": "b70f8", "orientation": [ 0, @@ -9765,8 +9898,11 @@ "CompactIdentifier:hmdb:HMDB0000852", "Beta-Sitosterol", "ChEBI:27693", - "ChEBI:27693", - "InChI:KZJWDPNRJALLNS-VJSFXXLFSA-N" + "InChI:KZJWDPNRJALLNS-VJSFXXLFSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9806,8 +9942,11 @@ "CompactIdentifier:hmdb:HMDB0000161", "Alanine", "ChEBI:16977", - "ChEBI:16977", - "InChI:QNAYBMKLOCPYGJ-REOHCLBHSA-N" + "InChI:QNAYBMKLOCPYGJ-REOHCLBHSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9847,8 +9986,11 @@ "CompactIdentifier:hmdb:HMDB0000849", "Rhamnose", "ChEBI:62346", - "ChEBI:62346", - "InChI:SHZGCJCMOBCMKK-JFNONXLTSA-N" + "InChI:SHZGCJCMOBCMKK-JFNONXLTSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9882,7 +10024,6 @@ 1 ] }, - "id": "ae551", "isAttachedTo": "b9080", "orientation": [ 0, @@ -9902,7 +10043,6 @@ 0 ] }, - "id": "ba50d", "isAttachedTo": "baae8", "orientation": [ 0, @@ -9948,8 +10088,11 @@ "CompactIdentifier:hmdb:HMDB0000163", "Maltose", "ChEBI:47937", - "ChEBI:47937", - "InChI:GUBGYTABKSRVRQ-DKBJLJRDSA-N" + "InChI:GUBGYTABKSRVRQ-DKBJLJRDSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10022,8 +10165,11 @@ "CompactIdentifier:hmdb:HMDB0000263", "Phosphoenolpyruvic acid", "ChEBI:44897", - "ChEBI:44897", - "InChI:DTBNBXWJWCWCIK-UHFFFAOYSA-N" + "InChI:DTBNBXWJWCWCIK-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10090,7 +10236,6 @@ 0.5 ] }, - "id": "c8294", "isAttachedTo": "eff60", "orientation": [ -1, @@ -10110,7 +10255,6 @@ 0.5 ] }, - "id": "f2f64", "isAttachedTo": "ca2f5", "orientation": [ -1, @@ -10157,8 +10301,9 @@ "DGDG", "Wikidata:Q42403316", "ChEBI:136795", - "ChEBI:136795", - "InChI:KDYAPQVYJXUQNY-OPHDRXFHSA-N" + "InChI:KDYAPQVYJXUQNY-OPHDRXFHSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10192,7 +10337,6 @@ 0 ] }, - "id": "a8931", "isAttachedTo": "afb92", "orientation": [ 0, @@ -10212,7 +10356,6 @@ 1 ] }, - "id": "f0963", "isAttachedTo": "f50f3", "orientation": [ 0, @@ -10252,7 +10395,6 @@ 0.5 ] }, - "id": "e5cbf", "isAttachedTo": "f596d", "orientation": [ -1, @@ -10272,7 +10414,6 @@ 0.5 ] }, - "id": "aba46", "isAttachedTo": "dfed5", "orientation": [ -1, @@ -10313,7 +10454,6 @@ 0 ] }, - "id": "cbfcc", "isAttachedTo": "fbbcf", "orientation": [ 0, @@ -10333,7 +10473,6 @@ 1 ] }, - "id": "a2d9e", "isAttachedTo": "ddf1c", "orientation": [ 0, @@ -10419,8 +10558,11 @@ "CompactIdentifier:hmdb:HMDB0001022", "Succinyl-CoA", "ChEBI:15380", - "ChEBI:15380", - "InChI:VNOYUJKHFWYWIR-ITIYDSSPSA-N" + "InChI:VNOYUJKHFWYWIR-ITIYDSSPSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10460,8 +10602,11 @@ "CompactIdentifier:hmdb:HMDB0002655", "Isorhamnetin", "ChEBI:6052", - "ChEBI:6052", - "InChI:IZQSVPBOUDKVDZ-UHFFFAOYSA-N" + "InChI:IZQSVPBOUDKVDZ-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10501,8 +10646,11 @@ "CompactIdentifier:hmdb:HMDB0001206", "Acetyl-CoA", "ChEBI:15351", - "ChEBI:15351", - "InChI:ZSLZBFCDCINBPY-ZSJPKINUSA-N" + "InChI:ZSLZBFCDCINBPY-ZSJPKINUSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10536,7 +10684,6 @@ 0.5 ] }, - "id": "c2532", "isAttachedTo": "b2251", "orientation": [ 1, @@ -10556,7 +10703,6 @@ 0.5 ] }, - "id": "abe77", "isAttachedTo": "dfed5", "orientation": [ 1, @@ -10602,8 +10748,11 @@ "CompactIdentifier:hmdb:HMDB0000883", "Valine", "ChEBI:16414", - "ChEBI:16414", - "InChI:KZSNJWFQEVHDMF-BYPYZUCNSA-N" + "InChI:KZSNJWFQEVHDMF-BYPYZUCNSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10637,7 +10786,6 @@ 0 ] }, - "id": "b5301", "isAttachedTo": "a771e", "orientation": [ 0, @@ -10657,7 +10805,6 @@ 1 ] }, - "id": "bdb2e", "isAttachedTo": "d914e", "orientation": [ 0, @@ -10697,7 +10844,6 @@ 1 ] }, - "id": "e830f", "isAttachedTo": "a4155", "orientation": [ 0, @@ -10717,7 +10863,6 @@ 0 ] }, - "id": "e8e8b", "isAttachedTo": "c3301", "orientation": [ 0, @@ -10763,8 +10908,11 @@ "CompactIdentifier:hmdb:HMDB0001264", "Dehydroascorbic acid", "ChEBI:27956", - "ChEBI:27956", - "InChI:SBJKKFFYIZUCET-JLAZNSOCSA-N" + "InChI:SBJKKFFYIZUCET-JLAZNSOCSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10798,7 +10946,6 @@ 0.5 ] }, - "id": "a6eff", "isAttachedTo": "a5894", "orientation": [ 1, @@ -10818,7 +10965,6 @@ 0.5 ] }, - "id": "a376c", "isAttachedTo": "b502b", "orientation": [ 1, @@ -10858,7 +11004,6 @@ 1 ] }, - "id": "bd93f", "isAttachedTo": "ca2f5", "orientation": [ 0, @@ -10878,7 +11023,6 @@ 0 ] }, - "id": "c6fc2", "isAttachedTo": "e079b", "orientation": [ 0, @@ -10924,7 +11068,8 @@ "CompactIdentifier:knapsack:C00006836", "A3", "Wikidata:Q23419072", - "InChI:JSYDBTWJIIAZPU-OMLFMJQWSA-O" + "InChI:JSYDBTWJIIAZPU-OMLFMJQWSA-O", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10958,7 +11103,6 @@ 0.5 ] }, - "id": "b06c0", "isAttachedTo": "e9da3", "orientation": [ -1, @@ -10978,7 +11122,6 @@ 0.5 ] }, - "id": "bcb59", "isAttachedTo": "b70f8", "orientation": [ -1, @@ -11024,7 +11167,8 @@ "CompactIdentifier:knapsack:C00007658", "A6", "Wikidata:Q23462761", - "InChI:OPWPCWHMCUWCGG-VTRYSJNRSA-O" + "InChI:OPWPCWHMCUWCGG-VTRYSJNRSA-O", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -11065,8 +11209,10 @@ "8-MTO", "Wikidata:Q27154958", "ChEBI:80989", - "ChEBI:80989", - "InChI:CWOJBEDMJKZKAB-JZYAIQKZSA-N" + "InChI:CWOJBEDMJKZKAB-JZYAIQKZSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -11100,7 +11246,6 @@ 0.5 ] }, - "id": "cd2f6", "isAttachedTo": "c3c5d", "orientation": [ -1, @@ -11120,7 +11265,6 @@ 1 ] }, - "id": "ab4b6", "isAttachedTo": "b502b", "orientation": [ 0, @@ -11160,7 +11304,6 @@ 0.5 ] }, - "id": "c3041", "isAttachedTo": "eff60", "orientation": [ 1, @@ -11180,7 +11323,6 @@ 0.5 ] }, - "id": "eab6a", "isAttachedTo": "f7ab6", "orientation": [ 1, @@ -11227,8 +11369,11 @@ "CompactIdentifier:hmdb:HMDB0000223", "Oxaloacetic acid", "ChEBI:30744", - "ChEBI:30744", - "InChI:KHPXUQMNIQBQEV-UHFFFAOYSA-N" + "InChI:KHPXUQMNIQBQEV-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -11262,7 +11407,6 @@ 0.5 ] }, - "id": "e3ed6", "isAttachedTo": "eff60", "orientation": [ 1, @@ -11282,7 +11426,6 @@ 0.5 ] }, - "id": "a6e95", "isAttachedTo": "bcbab", "orientation": [ 1, @@ -11323,7 +11466,6 @@ 1 ] }, - "id": "e6d0c", "isAttachedTo": "c2faf", "orientation": [ 0, @@ -11343,7 +11485,6 @@ 0 ] }, - "id": "c901c", "isAttachedTo": "a45f1", "orientation": [ 0, @@ -11390,7 +11531,8 @@ "CompactIdentifier:knapsack:C00005188", "F20", "Wikidata:Q23048396", - "InChI:MBLYALXOUBKFNE-NAYQWVCRSA-N" + "InChI:MBLYALXOUBKFNE-NAYQWVCRSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -11424,7 +11566,6 @@ 1 ] }, - "id": "e7572", "isAttachedTo": "cbb49", "orientation": [ 0, @@ -11444,7 +11585,6 @@ 0 ] }, - "id": "e08b2", "isAttachedTo": "a4155", "orientation": [ 0, @@ -11491,8 +11631,11 @@ "CompactIdentifier:hmdb:HMDB0000191", "Aspartic acid", "ChEBI:17053", - "ChEBI:17053", - "InChI:CKLJMWTZIZZHCS-REOHCLBHSA-N" + "InChI:CKLJMWTZIZZHCS-REOHCLBHSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -11526,7 +11669,6 @@ 0 ] }, - "id": "d86a6", "isAttachedTo": "cb6df", "orientation": [ 0, @@ -11546,7 +11688,6 @@ 1 ] }, - "id": "af6d2", "isAttachedTo": "c2faf", "orientation": [ 0, @@ -11587,7 +11728,6 @@ 0.5 ] }, - "id": "bdf8d", "isAttachedTo": "b82cb", "orientation": [ 1, @@ -11607,7 +11747,6 @@ 0.5 ] }, - "id": "d8748", "isAttachedTo": "a4155", "orientation": [ 1, @@ -11654,8 +11793,11 @@ "CompactIdentifier:hmdb:HMDB0000696", "Methionine", "ChEBI:16643", - "ChEBI:16643", - "InChI:FFEARJCKVFRZRR-BYPYZUCNSA-N" + "InChI:FFEARJCKVFRZRR-BYPYZUCNSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -11689,7 +11831,6 @@ 0.5 ] }, - "id": "b606c", "isAttachedTo": "a4155", "orientation": [ 1, @@ -11709,7 +11850,6 @@ 0.5 ] }, - "id": "f27c5", "isAttachedTo": "b4854", "orientation": [ 1, @@ -11750,7 +11890,6 @@ 0.5 ] }, - "id": "f1ac9", "isAttachedTo": "e1686", "orientation": [ -1, @@ -11770,7 +11909,6 @@ 0.5 ] }, - "id": "c5991", "isAttachedTo": "b329c", "orientation": [ -1, @@ -11810,7 +11948,6 @@ 0.5 ] }, - "id": "d0252", "isAttachedTo": "f0f6a", "orientation": [ 1, @@ -11830,7 +11967,6 @@ 0.5 ] }, - "id": "ddc7e", "isAttachedTo": "a9dfd", "orientation": [ 1, @@ -11871,7 +12007,6 @@ 0.5 ] }, - "id": "fb150", "isAttachedTo": "f596d", "orientation": [ -1, @@ -11891,7 +12026,6 @@ 0.5 ] }, - "id": "da0f3", "isAttachedTo": "c1c60", "orientation": [ -1, @@ -11932,7 +12066,6 @@ 0.5 ] }, - "id": "b0814", "isAttachedTo": "b70f8", "orientation": [ -1, @@ -11952,7 +12085,6 @@ 0.5 ] }, - "id": "d52f7", "isAttachedTo": "be281", "orientation": [ -1, @@ -11998,7 +12130,8 @@ "CompactIdentifier:knapsack:C00005526", "F27", "Wikidata:Q23049767", - "InChI:UXXAEVMOIUAYQT-KEXGRDQZSA-N" + "InChI:UXXAEVMOIUAYQT-KEXGRDQZSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -12038,8 +12171,10 @@ "CompactIdentifier:hmdb:HMDB0000211", "Myoinositol", "ChEBI:17268", - "ChEBI:17268", - "InChI:CDAISMWEOUEBRE-GPIVLXJGSA-N" + "InChI:CDAISMWEOUEBRE-GPIVLXJGSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -12079,8 +12214,11 @@ "CompactIdentifier:hmdb:HMDB0000124", "Fructose-6-phosphate", "ChEBI:15946", - "ChEBI:15946", - "InChI:GSXOAOHZAIYLCY-HSUXUTPPSA-N" + "InChI:GSXOAOHZAIYLCY-HSUXUTPPSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -12120,8 +12258,10 @@ "CompactIdentifier:hmdb:HMDB0000067", "Cholesterol", "ChEBI:16113", - "ChEBI:16113", - "InChI:HVYWMOMLDIMFJA-DPAQBDIFSA-N" + "InChI:HVYWMOMLDIMFJA-DPAQBDIFSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -12155,7 +12295,6 @@ 1 ] }, - "id": "fbf21", "isAttachedTo": "e1d01", "orientation": [ 0, @@ -12175,7 +12314,6 @@ 0 ] }, - "id": "c1d2a", "isAttachedTo": "a296e", "orientation": [ 0, @@ -12221,8 +12359,11 @@ "CompactIdentifier:hmdb:HMDB0003213", "Raffinose", "ChEBI:16634", - "ChEBI:16634", - "InChI:MUPFEKGTMRGPLJ-ZQSKZDJDSA-N" + "InChI:MUPFEKGTMRGPLJ-ZQSKZDJDSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -12256,7 +12397,6 @@ 0.5 ] }, - "id": "f25d7", "isAttachedTo": "f1641", "orientation": [ -1, @@ -12276,7 +12416,6 @@ 0.5 ] }, - "id": "f5407", "isAttachedTo": "bef70", "orientation": [ -1, @@ -12316,7 +12455,6 @@ 0.5 ] }, - "id": "ae3a3", "isAttachedTo": "c3643", "orientation": [ 1, @@ -12336,7 +12474,6 @@ 0.5 ] }, - "id": "a98ba", "isAttachedTo": "c2faf", "orientation": [ 1, @@ -12376,7 +12513,6 @@ 0.5 ] }, - "id": "ded4f", "isAttachedTo": "ba1b9", "orientation": [ 1, @@ -12396,7 +12532,6 @@ 0.5 ] }, - "id": "c036b", "isAttachedTo": "d95b3", "orientation": [ 1, @@ -12436,7 +12571,6 @@ 0.5 ] }, - "id": "c42f2", "isAttachedTo": "d6a79", "orientation": [ 1, @@ -12456,7 +12590,6 @@ 0.5 ] }, - "id": "f5061", "isAttachedTo": "bc576", "orientation": [ 1, @@ -12535,8 +12668,11 @@ "CompactIdentifier:hmdb:HMDB0000158", "Tyrosine", "ChEBI:17895", - "ChEBI:17895", - "InChI:OUYCCCASQSFEME-QMMMGPOBSA-N" + "InChI:OUYCCCASQSFEME-QMMMGPOBSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -12576,7 +12712,9 @@ "CompactIdentifier:chemspider:4946694", "PC", "Wikidata:Q42403329", - "InChI:XXKFQTJOJZELMD-RSLAUBRISA-N" + "InChI:XXKFQTJOJZELMD-RSLAUBRISA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -12610,7 +12748,6 @@ 0 ] }, - "id": "b7794", "isAttachedTo": "ddf1c", "orientation": [ 0, @@ -12630,7 +12767,6 @@ 1 ] }, - "id": "b26e4", "isAttachedTo": "f596d", "orientation": [ 0, @@ -12670,7 +12806,6 @@ 0.5 ] }, - "id": "ca042", "isAttachedTo": "b502b", "orientation": [ 1, @@ -12690,7 +12825,6 @@ 0.5 ] }, - "id": "d1cbb", "isAttachedTo": "dfaae", "orientation": [ 1, @@ -12731,7 +12865,6 @@ 1 ] }, - "id": "fc4f8", "isAttachedTo": "a42b5", "orientation": [ 0, @@ -12751,7 +12884,6 @@ 0 ] }, - "id": "b6934", "isAttachedTo": "cb90e", "orientation": [ 0, @@ -12798,8 +12930,10 @@ "Nicotianamine", "Wikidata:Q11324211", "ChEBI:17721", - "ChEBI:17721", - "InChI:KRGPXXHMOXVMMM-CIUDSAMLSA-N" + "InChI:KRGPXXHMOXVMMM-CIUDSAMLSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -12839,8 +12973,11 @@ "CompactIdentifier:hmdb:HMDB0000929", "Tryptophan", "ChEBI:16828", - "ChEBI:16828", - "InChI:QIVBCDIJIAJPQS-VIFPVBQESA-N" + "InChI:QIVBCDIJIAJPQS-VIFPVBQESA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -12874,7 +13011,6 @@ 0.5 ] }, - "id": "d9477", "isAttachedTo": "c3643", "orientation": [ 1, @@ -12894,7 +13030,6 @@ 0.5 ] }, - "id": "beceb", "isAttachedTo": "f9ba1", "orientation": [ 1, @@ -12974,7 +13109,6 @@ 0.5 ] }, - "id": "c9c08", "isAttachedTo": "f9ba1", "orientation": [ 1, @@ -12994,7 +13128,6 @@ 0.5 ] }, - "id": "e5f79", "isAttachedTo": "a0c48", "orientation": [ 1, @@ -13034,7 +13167,6 @@ 0.5 ] }, - "id": "c8bee", "isAttachedTo": "eb629", "orientation": [ 1, @@ -13054,7 +13186,6 @@ 0.5 ] }, - "id": "e15fd", "isAttachedTo": "c3643", "orientation": [ 1, @@ -13101,8 +13232,9 @@ "F4", "Wikidata:Q23417271", "ChEBI:133218", - "ChEBI:133218", - "InChI:QFSDWLPMRWDFID-CSNYLUTCSA-N" + "InChI:QFSDWLPMRWDFID-CSNYLUTCSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -13142,8 +13274,11 @@ "CompactIdentifier:hmdb:HMDB0001414", "Putrescine", "ChEBI:17148", - "ChEBI:17148", - "InChI:KIDHWZJUCRJVML-UHFFFAOYSA-N" + "InChI:KIDHWZJUCRJVML-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -13216,8 +13351,11 @@ "CompactIdentifier:hmdb:HMDB0000673", "C18:2", "ChEBI:17351", - "ChEBI:17351", - "InChI:OYHQOLUKZRVURQ-HZJYTTRNSA-N" + "InChI:OYHQOLUKZRVURQ-HZJYTTRNSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -13284,7 +13422,6 @@ 0.5 ] }, - "id": "b574e", "isAttachedTo": "a4155", "orientation": [ 1, @@ -13304,7 +13441,6 @@ 0.5 ] }, - "id": "c97d5", "isAttachedTo": "c560c", "orientation": [ 1, @@ -13351,7 +13487,8 @@ "CompactIdentifier:chemspider:20058759", "PI", "Wikidata:Q42403300", - "InChI:IBUKXRINTKQBRQ-PZDJRWDQSA-N" + "InChI:IBUKXRINTKQBRQ-PZDJRWDQSA-N", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -13395,7 +13532,6 @@ 0.5 ] }, - "id": "ed7d8", "isAttachedTo": "a9dfd", "orientation": [ -1, @@ -13415,7 +13551,6 @@ 0.5 ] }, - "id": "f2e04", "isAttachedTo": "a2c95", "orientation": [ -1, @@ -13455,7 +13590,6 @@ 0 ] }, - "id": "c9c11", "isAttachedTo": "bfe2d", "orientation": [ 0, @@ -13475,7 +13609,6 @@ 1 ] }, - "id": "b4fea", "isAttachedTo": "a40e2", "orientation": [ 0, @@ -13515,7 +13648,6 @@ 0.5 ] }, - "id": "b9c47", "isAttachedTo": "f814c", "orientation": [ 1, @@ -13535,7 +13667,6 @@ 0.5 ] }, - "id": "a67b0", "isAttachedTo": "aece3", "orientation": [ 1, @@ -13575,7 +13706,6 @@ 1 ] }, - "id": "c6bcb", "isAttachedTo": "f4462", "orientation": [ 0, @@ -13595,7 +13725,6 @@ 0 ] }, - "id": "abbc2", "isAttachedTo": "be96c", "orientation": [ 0, @@ -13635,7 +13764,6 @@ 1 ] }, - "id": "ca3e3", "isAttachedTo": "be96c", "orientation": [ 0, @@ -13655,7 +13783,6 @@ 0 ] }, - "id": "e7eef", "isAttachedTo": "e8559", "orientation": [ 0, @@ -13695,7 +13822,6 @@ 1 ] }, - "id": "ce12f", "isAttachedTo": "f79de", "orientation": [ 0, @@ -13715,7 +13841,6 @@ 0 ] }, - "id": "c71e7", "isAttachedTo": "b82cb", "orientation": [ 0, @@ -13755,7 +13880,6 @@ 1 ] }, - "id": "a32e7", "isAttachedTo": "eff60", "orientation": [ 0, @@ -13775,7 +13899,6 @@ 0 ] }, - "id": "d7404", "isAttachedTo": "f4462", "orientation": [ 0, @@ -13815,7 +13938,6 @@ 1 ] }, - "id": "af5b4", "isAttachedTo": "be281", "orientation": [ 0, @@ -13835,7 +13957,6 @@ 0 ] }, - "id": "c2281", "isAttachedTo": "af271", "orientation": [ 0, @@ -13875,7 +13996,6 @@ 1 ] }, - "id": "ca005", "isAttachedTo": "c37e2", "orientation": [ 0, @@ -13895,7 +14015,6 @@ 0 ] }, - "id": "b8b2b", "isAttachedTo": "f79de", "orientation": [ 0, @@ -13935,7 +14054,6 @@ 1 ] }, - "id": "cad6f", "isAttachedTo": "c6818", "orientation": [ 0, @@ -13955,7 +14073,6 @@ 0 ] }, - "id": "a661b", "isAttachedTo": "eeeaf", "orientation": [ 0, @@ -13995,7 +14112,6 @@ 1 ] }, - "id": "e5a46", "isAttachedTo": "a9dfd", "orientation": [ 0, @@ -14015,7 +14131,6 @@ 0 ] }, - "id": "d3829", "isAttachedTo": "eff60", "orientation": [ 0, @@ -14055,7 +14170,6 @@ 1 ] }, - "id": "e4b4e", "isAttachedTo": "bb028", "orientation": [ 0, @@ -14075,7 +14189,6 @@ 0 ] }, - "id": "aa89d", "isAttachedTo": "c6818", "orientation": [ 0, @@ -14115,7 +14228,6 @@ 1 ] }, - "id": "d352f", "isAttachedTo": "e49ed", "orientation": [ 0, @@ -14135,7 +14247,6 @@ 0 ] }, - "id": "fc8e9", "isAttachedTo": "eb629", "orientation": [ 0, @@ -14175,7 +14286,6 @@ 1 ] }, - "id": "cc38c", "isAttachedTo": "f4462", "orientation": [ 0, @@ -14195,7 +14305,6 @@ 0 ] }, - "id": "f4ae0", "isAttachedTo": "a40e2", "orientation": [ 0, @@ -14235,7 +14344,6 @@ 1 ] }, - "id": "b18b1", "isAttachedTo": "eb629", "orientation": [ 0, @@ -14255,7 +14363,6 @@ 0 ] }, - "id": "aa3d1", "isAttachedTo": "a9dfd", "orientation": [ 0, @@ -14295,7 +14402,6 @@ 1 ] }, - "id": "b3ea1", "isAttachedTo": "cd3ef", "orientation": [ 0, @@ -14315,7 +14421,6 @@ 0 ] }, - "id": "d93fb", "isAttachedTo": "eeeaf", "orientation": [ 0, @@ -14355,7 +14460,6 @@ 0.5 ] }, - "id": "ee17c", "isAttachedTo": "aece3", "orientation": [ 1, @@ -14375,7 +14479,6 @@ 0.5 ] }, - "id": "b26e7", "isAttachedTo": "be281", "orientation": [ 1, @@ -14416,7 +14519,6 @@ 1 ] }, - "id": "f9851", "isAttachedTo": "baf30", "orientation": [ 0, @@ -14436,7 +14538,6 @@ 0 ] }, - "id": "c4a75", "isAttachedTo": "f79de", "orientation": [ 0, @@ -14476,7 +14577,6 @@ 1 ] }, - "id": "dfb2b", "isAttachedTo": "af271", "orientation": [ 0, @@ -14496,7 +14596,6 @@ 0 ] }, - "id": "e5eee", "isAttachedTo": "baf30", "orientation": [ 0, @@ -14536,7 +14635,6 @@ 0 ] }, - "id": "a3ec6", "isAttachedTo": "c37e2", "orientation": [ 0, @@ -14556,7 +14654,6 @@ 1 ] }, - "id": "c00a1", "isAttachedTo": "be281", "orientation": [ 0, @@ -14596,7 +14693,6 @@ 0.5 ] }, - "id": "bd459", "isAttachedTo": "a9dfd", "orientation": [ -1, @@ -14616,7 +14712,6 @@ 0.5 ] }, - "id": "e50ff", "isAttachedTo": "e9980", "orientation": [ -1, @@ -14656,7 +14751,6 @@ 0 ] }, - "id": "b286f", "isAttachedTo": "cd3ef", "orientation": [ 0, @@ -14676,7 +14770,6 @@ 1 ] }, - "id": "d2166", "isAttachedTo": "bfe2d", "orientation": [ 0, @@ -14716,7 +14809,6 @@ 0.5 ] }, - "id": "e546a", "isAttachedTo": "ebd7e", "orientation": [ 1, @@ -14736,7 +14828,6 @@ 0.5 ] }, - "id": "aa382", "isAttachedTo": "a42b5", "orientation": [ 1, @@ -14777,7 +14868,6 @@ 1 ] }, - "id": "c03b9", "isAttachedTo": "e8559", "orientation": [ 0, @@ -14797,7 +14887,6 @@ 0 ] }, - "id": "ac6cc", "isAttachedTo": "bb028", "orientation": [ 0, @@ -14837,7 +14926,6 @@ 0 ] }, - "id": "cee1b", "isAttachedTo": "e49ed", "orientation": [ 0, @@ -14857,7 +14945,6 @@ 1 ] }, - "id": "d1f8c", "isAttachedTo": "b82cb", "orientation": [ 0, @@ -14941,7 +15028,7 @@ "@context": [ "https://cdn.rawgit.com/wikipathways/WpVocabularies/7a46a05/contexts/pvjs.jsonld", { - "@base": "http://identifiers.org/wikipathways/WP3622/" + "@base": "WP3622/" } ], "author": "[Afukushima, Ariutta, Egonw, Mkutmon]", @@ -15254,7 +15341,7 @@ "a0061", "f4ee9" ], - "dataSourceVersion": "WP3622_r105906", + "dataSourceVersion": "WP3622_r134270", "displayName": "AtMetExpress overview", "drawAs": "rect", "fill": "white", @@ -15262,9 +15349,9 @@ "fontWeight": "bold", "gpmlElementName": "Pathway", "height": 935, - "id": "http://identifiers.org/wikipathways/WP3622", + "id": "WP3622", "kaavioType": "Group", - "lastModified": "20190816114002", + "lastModified": "20240719064653", "name": "AtMetExpress overview", "organism": "Arabidopsis thaliana", "padding": 5, @@ -15273,7 +15360,7 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: AtMetExpress overview\nLast Modified: 20190816114002\nOrganism: Arabidopsis thaliana", + "textContent": "Name: AtMetExpress overview\nLast Modified: 20240719064653\nOrganism: Arabidopsis thaliana", "type": [ "Pathway", "http://identifiers.org/pw/PW:0000002" diff --git a/pathways/WP3622/WP3622.png b/pathways/WP3622/WP3622.png index 2bed2f71a..b3bebbcf7 100644 Binary files a/pathways/WP3622/WP3622.png and b/pathways/WP3622/WP3622.png differ diff --git a/pathways/WP3622/WP3622.svg b/pathways/WP3622/WP3622.svg index 880c854e3..c288abb89 100644 --- a/pathways/WP3622/WP3622.svg +++ b/pathways/WP3622/WP3622.svg @@ -1,5 +1,5 @@ - + @@ -442,8 +442,8 @@ - - + + @@ -1827,7 +1827,7 @@ - + 3-MTP @@ -1851,7 +1851,7 @@ 4-MTB - + 5-MTP @@ -2112,9 +2112,9 @@ - + Name: AtMetExpress overview - Last Modified: 20190816114002 + Last Modified: 20240719064653 Organism: Arabidopsis thaliana diff --git a/pathways/WP3651/WP3651-bibliography.tsv b/pathways/WP3651/WP3651-bibliography.tsv index 4672a2387..6d6ac1a29 100644 --- a/pathways/WP3651/WP3651-bibliography.tsv +++ b/pathways/WP3651/WP3651-bibliography.tsv @@ -1,2 +1,2 @@ ID Database Citation -23685749 Pubmed "Ho AS, Kannan K, Roy DM, Morris LGT, Ganly I, Katabi N, et al. The mutational landscape of adenoid cystic carcinoma. Nat Genet. 2013 Jul;45(7):791–8. PubMed Europe PMC Scholia" +23685749 Pubmed "The mutational landscape of adenoid cystic carcinoma. Ho AS, Kannan K, Roy DM, Morris LGT, Ganly I, Katabi N, et al. Nat Genet. 2013 Jul;45(7):791–8. PubMed Europe PMC Scholia" diff --git a/pathways/WP3651/WP3651-datanodes.tsv b/pathways/WP3651/WP3651-datanodes.tsv index 2483ba460..777e08c82 100644 --- a/pathways/WP3651/WP3651-datanodes.tsv +++ b/pathways/WP3651/WP3651-datanodes.tsv @@ -1,72 +1,68 @@ -Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI -SMARCA2 GeneProduct ensembl:ENSG00000080503 ensembl:ENSG00000080503 ncbigene:6595 hgnc.symbol:SMARCA2 uniprot:A0A0U1RQW7;uniprot:A0A0U1RR45;uniprot:F6XE55;uniprot:A0A0U1RR26;uniprot:A0A0U1RR09;uniprot:A0A0U1RQE1;uniprot:B1ALF6;uniprot:F6VDE0;uniprot:A0A0U1RRG6;uniprot:A0A1B0GTC9;uniprot:A0A1W2PS06;uniprot:A0A0U1RQX3;uniprot:A0A1B0GWA8;uniprot:P51531;uniprot:A0A0U1RQZ9;uniprot:A0A0U1RQP3;uniprot:F6T8Q0;uniprot:A0A0U1RRN2;uniprot:A0A1B0GUV6;uniprot:A0A1B0GU54;uniprot:B4DNT1;uniprot:F6RS74;uniprot:A0A0U1RRJ4;uniprot:A0A0U1RRJ8;uniprot:A0A0A0MT03;uniprot:A0A0U1RRF5;uniprot:B1ALG2;uniprot:F6UH26;uniprot:A0A0A0MSS5;uniprot:A0A0U1RRD6;uniprot:A0A0U1RRF8;uniprot:B1ALG1;uniprot:A0A0U1RQU0;uniprot:A0A0U1RR83;uniprot:A0A0U1RQS1 -SMARCE1 GeneProduct ensembl:ENSG00000073584 ensembl:ENSG00000073584 ncbigene:6605 hgnc.symbol:SMARCE1 uniprot:B4DGM3;uniprot:A0A2R8Y7I9;uniprot:A0A2R8YDQ4;uniprot:J3QKS7;uniprot:A0A2R8YD78;uniprot:A0A2R8YES3;uniprot:J3QR61;uniprot:J3QL66;uniprot:J3QKX6;uniprot:J3KT85;uniprot:J3QS32;uniprot:A0A2U3TZQ7;uniprot:A0A2R8Y765;uniprot:A0A2R8Y7U4;uniprot:A0A024R1S7;uniprot:A0A2R8Y4T4;uniprot:A0A2R8YEB8;uniprot:A0A2R8YFC8;uniprot:A0A2R8YDD9;uniprot:Q969G3;uniprot:A0A2R8Y855 -ATRX GeneProduct ensembl:ENSG00000085224 ensembl:ENSG00000085224 ncbigene:546 hgnc.symbol:ATRX uniprot:A0A096LNW1;uniprot:P46100;uniprot:A0A096LPG6;uniprot:A0A096LNL9;uniprot:A0A6Q8PHA4;uniprot:H0Y3T0;uniprot:A0A096LNL6;uniprot:A0A096LNL7;uniprot:A0A096LNN3;uniprot:A0A096LNR8;uniprot:A0A096LP59;uniprot:A0A087WWG0;uniprot:A4LAA3;uniprot:A0A096LNX6 -ARID1A GeneProduct ensembl:ENSG00000117713 ensembl:ENSG00000117713 ncbigene:8289 hgnc.symbol:ARID1A uniprot:A0A1B0GVT5;uniprot:O14497;uniprot:A0A1B0GTU5;uniprot:E9PQW6;uniprot:H0YEW5;uniprot:H0Y488;uniprot:H0YCU6 -SRCAP GeneProduct ensembl:ENSG00000080603 ensembl:ENSG00000080603 ncbigene:10847 hgnc.symbol:SRCAP uniprot:A0A087X0E3;uniprot:A0A0A0MS59;uniprot:C9J4U4;uniprot:Q6ZRS2 -CREBBP GeneProduct ensembl:ENSG00000005339 ensembl:ENSG00000005339 ncbigene:1387 hgnc.symbol:CREBBP uniprot:Q92793;uniprot:I3L466;uniprot:A0A1B0GUU0;uniprot:I3L3I5;uniprot:I3L0Q1;uniprot:I3L293 -MORF4L1 GeneProduct ensembl:ENSG00000185787 ensembl:ENSG00000185787 ncbigene:10933 hgnc.symbol:MORF4L1 uniprot:B3KTM8;uniprot:Q9UBU8;uniprot:H0YMT8;uniprot:H0YNI8;uniprot:H0YM21;uniprot:H0YLV1;uniprot:H0YNE0;uniprot:H0YNX3;uniprot:H0YMJ0;uniprot:H0YLJ3 -KAT6A GeneProduct ensembl:ENSG00000083168 ensembl:ENSG00000083168 ncbigene:7994 hgnc.symbol:KAT6A uniprot:A0A3B3ITI3;uniprot:Q92794;uniprot:A0A3B3ISZ3;uniprot:A5PLL3;uniprot:A0A3F2YNX6;uniprot:A0A3B3ISU5;uniprot:A0A3B3IS53;uniprot:C9JJY6 -BRD1 GeneProduct ensembl:ENSG00000100425 ensembl:ENSG00000100425 ncbigene:23774 hgnc.symbol:BRD1 uniprot:J3KQ61;uniprot:A0A024R4W4;uniprot:A0A024R4V5;uniprot:O95696 -EP300 GeneProduct ensembl:ENSG00000100393 ensembl:ENSG00000100393 ncbigene:2033 hgnc.symbol:EP300 uniprot:A0A0U1RR87;uniprot:A0A669KB12;uniprot:Q09472 -KANSL1 GeneProduct ensembl:ENSG00000120071 ensembl:ENSG00000120071 ncbigene:284058 hgnc.symbol:KANSL1 uniprot:A0A1W2PS83;uniprot:Q7Z3B3;uniprot:A0A1W2PRA9;uniprot:A0A024R9Y2;uniprot:A0A0G2JQP8;uniprot:A0A1W2PRR3;uniprot:I3L233;uniprot:A0A3B3IT55;uniprot:A0A1W2PRB5;uniprot:A0A1W2PPV8;uniprot:A0A1W2PQT4 -SETD2 GeneProduct ensembl:ENSG00000181555 ensembl:ENSG00000181555 ncbigene:29072 hgnc.symbol:SETD2 uniprot:H7BXT4;uniprot:H7BZ93;uniprot:Q9BYW2;uniprot:H7C3H4;uniprot:C9JG86;uniprot:A0A1W2PPX9 -NSD1 GeneProduct ensembl:ENSG00000165671 ensembl:ENSG00000165671 ncbigene:64324 hgnc.symbol:NSD1 uniprot:D6RG26;uniprot:Q96L73;uniprot:H7BYB0;uniprot:D6RA58;uniprot:A0A1W2PS55;uniprot:D6RE14;uniprot:D6RBP3 -KMT2C GeneProduct ensembl:ENSG00000055609 ensembl:ENSG00000055609 ncbigene:58508 hgnc.symbol:KMT2C uniprot:Q8NEZ4;uniprot:C9J4Z5;uniprot:H7C212;uniprot:H0Y765;uniprot:H0YNL4;uniprot:H7C2V8;uniprot:H7BY37 -CMTR2 GeneProduct ensembl:ENSG00000180917 ensembl:ENSG00000180917 ncbigene:55783 hgnc.symbol:CMTR2 uniprot:H3BTZ7;uniprot:H3BS00;uniprot:Q8IYT2;uniprot:H3BNZ8;uniprot:H3BUK2;uniprot:H3BR19 -ARID4B GeneProduct ensembl:ENSG00000054267 ensembl:ENSG00000054267 ncbigene:51742 hgnc.symbol:ARID4B uniprot:H7C5R6;uniprot:X6RCR8;uniprot:H0Y7Y8;uniprot:Q4LE39 -BCOR GeneProduct ensembl:ENSG00000183337 ensembl:ENSG00000183337 ncbigene:54880 hgnc.symbol:BCOR uniprot:Q6W2J9;uniprot:A0A5F9ZGX7;uniprot:H7C2V9;uniprot:H7BYY2;uniprot:C9JHP3;uniprot:H7BZ37;uniprot:H7C231;uniprot:A1A564 -BCORL1 GeneProduct ensembl:ENSG00000085185 ensembl:ENSG00000085185 ncbigene:63035 hgnc.symbol:BCORL1 uniprot:Q5H9F3;uniprot:H7C4B2;uniprot:V9GYD4;uniprot:A0A087X1F0 -KDM6B GeneProduct ensembl:ENSG00000132510 ensembl:ENSG00000132510 ncbigene:23135 hgnc.symbol:KDM6B uniprot:I3L0Z0;uniprot:O15054 -KDM6A GeneProduct ensembl:ENSG00000147050 ensembl:ENSG00000147050 ncbigene:7403 hgnc.symbol:KDM6A uniprot:A0A087X0R0;uniprot:O15550;uniprot:A0A6Q8PHJ0;uniprot:F8W8R6;uniprot:A0A6Q8PFD0;uniprot:F5H6S1;uniprot:F5H5V6;uniprot:A0A6Q8PGG6;uniprot:A0A6Q8PHB6;uniprot:H0Y6I7;uniprot:A0A087WUN6;uniprot:A0A6Q8PG92;uniprot:A0A6Q8PH94;uniprot:A0A6Q8PGN0;uniprot:A0A6Q8PG32;uniprot:A0A6Q8PFK0;uniprot:H0Y6V5 -ARID5B GeneProduct ensembl:ENSG00000150347 ensembl:ENSG00000150347 ncbigene:84159 hgnc.symbol:ARID5B uniprot:Q14865;uniprot:A0A2R8Y5F2 -JMJD1C GeneProduct ensembl:ENSG00000171988 ensembl:ENSG00000171988 ncbigene:221037 hgnc.symbol:JMJD1C uniprot:H7BXU7;uniprot:Q15652 -HIST1H1E GeneProduct ensembl:ENSG00000168298 ensembl:ENSG00000168298 ncbigene:3008 hgnc.symbol:H1-4 uniprot:A3R0T8;uniprot:P10412 -HIST1H2AL GeneProduct ensembl:ENSG00000276903 ensembl:ENSG00000276903 ncbigene:8332 hgnc.symbol:H2AC16 uniprot:A4FTV9;uniprot:P0C0S8 -PRKDC GeneProduct ensembl:ENSG00000253729 ensembl:ENSG00000253729 ncbigene:5591 hgnc.symbol:PRKDC uniprot:F5GX40;uniprot:H0YG84;uniprot:P78527 -ATM GeneProduct ensembl:ENSG00000149311 ensembl:ENSG00000149311 ncbigene:472 hgnc.symbol:ATM uniprot:E9PIN0;uniprot:Q6P7P1;uniprot:Q13315;uniprot:H0YDU7;uniprot:A0A087X0E9;uniprot:A0A6Q8PH76;uniprot:M0QXY8;uniprot:H0YEC6;uniprot:A0A024R3C7;uniprot:E9PRG7 -CREBBP GeneProduct ensembl:ENSG00000005339 ensembl:ENSG00000005339 ncbigene:1387 hgnc.symbol:CREBBP uniprot:Q92793;uniprot:I3L466;uniprot:A0A1B0GUU0;uniprot:I3L3I5;uniprot:I3L0Q1;uniprot:I3L293 -SMC1A GeneProduct ensembl:ENSG00000072501 ensembl:ENSG00000072501 ncbigene:8243 hgnc.symbol:SMC1A uniprot:A0A384MR33;uniprot:V9GYN9;uniprot:A0A6Q8PHC3;uniprot:Q14683;uniprot:G8JLG1;uniprot:V9GY57 -BRCA1 GeneProduct ensembl:ENSG00000012048 ensembl:ENSG00000012048 ncbigene:672 hgnc.symbol:BRCA1 uniprot:C6YB45;uniprot:Q3B891;uniprot:C9IZW4;uniprot:A0A0A0MSN1;uniprot:E7EQW4;uniprot:P38398;uniprot:A0A494C182;uniprot:A0A0U1RRA9;uniprot:A0A2R8Y7V5;uniprot:B7ZA85;uniprot:H0Y850;uniprot:K7EPC7;uniprot:E7EUM2;uniprot:E7EWN5;uniprot:G1UI37;uniprot:E7ENB7;uniprot:E9PH68;uniprot:A0A024R1V0;uniprot:H0Y8B8;uniprot:H0Y881;uniprot:A0A024R1Z8;uniprot:H0Y8D8;uniprot:A0A2R8Y6Y9;uniprot:K7EJW3;uniprot:Q5YLB2;uniprot:A0A2R8Y587;uniprot:E9PC22 -TP53 GeneProduct ensembl:ENSG00000141510 ensembl:ENSG00000141510 ncbigene:7157 hgnc.symbol:TP53 uniprot:E9PFT5;uniprot:A0A087WXZ1;uniprot:P04637;uniprot:A0A087X1Q1;uniprot:E7ESS1;uniprot:E7EMR6;uniprot:E7EQX7;uniprot:A0A0U1RQC9;uniprot:J3KP33;uniprot:H2EHT1;uniprot:I3L0W9;uniprot:K7PPA8;uniprot:S4R334;uniprot:A0A087WT22;uniprot:E9PCY9 -UHRF1 GeneProduct ensembl:ENSG00000276043 ensembl:ENSG00000276043 ncbigene:29128 hgnc.symbol:UHRF1 uniprot:A0A087WTW0;uniprot:A0A087WWG9;uniprot:Q96T88;uniprot:A0A087WVR3 -TLK1 GeneProduct ensembl:ENSG00000198586 ensembl:ENSG00000198586 ncbigene:9874 hgnc.symbol:TLK1 uniprot:F8W7X8;uniprot:C9JWT6;uniprot:Q9UKI8;uniprot:B3KRP1 -CDC2 GeneProduct ncbiprotein:78070384 -MYBL1 GeneProduct ensembl:ENSG00000185697 ensembl:ENSG00000185697 ncbigene:4603 hgnc.symbol:MYBL1 uniprot:E7EWZ1;uniprot:P10243 -MYB GeneProduct ensembl:ENSG00000118513 ensembl:ENSG00000118513 ncbigene:4602 hgnc.symbol:MYB uniprot:E9PJ96;uniprot:E9PN92;uniprot:E9PJT2;uniprot:E9PLN0;uniprot:E9PPR4;uniprot:F8W8G5;uniprot:E9PMZ0;uniprot:E9PKZ3;uniprot:P10242;uniprot:Q708E3;uniprot:E9PIW4;uniprot:Q708E5;uniprot:E9PMQ0;uniprot:Q708E6;uniprot:E9PP87;uniprot:Q708E9;uniprot:Q708E8;uniprot:E9PN43;uniprot:A0A0C4DG19;uniprot:E9PQQ2;uniprot:E9PJF1;uniprot:A0A087WTI6;uniprot:H0YCN6;uniprot:E9PNH6;uniprot:E9PPL8 -NFIB GeneProduct ensembl:ENSG00000147862 ensembl:ENSG00000147862 ncbigene:4781 hgnc.symbol:NFIB uniprot:U3KPY9;uniprot:O00712;uniprot:Q5VW28;uniprot:Q5VW26;uniprot:A0A1B0GU97;uniprot:Q5VW27;uniprot:A0A1B0GTC1;uniprot:A0A1B0GWJ4;uniprot:A0A1B0GVN4;uniprot:A0A1B0GW37;uniprot:Q5W0Y9;uniprot:A0A1B0GWI9;uniprot:U3KQE8;uniprot:A0A0A0MRX8;uniprot:Q5VW31;uniprot:A0A1B0GWB8;uniprot:A0A2R8Y7V8;uniprot:Q5VW30 -CREBBP GeneProduct ensembl:ENSG00000005339 ensembl:ENSG00000005339 ncbigene:1387 hgnc.symbol:CREBBP uniprot:Q92793;uniprot:I3L466;uniprot:A0A1B0GUU0;uniprot:I3L3I5;uniprot:I3L0Q1;uniprot:I3L293 -MYCBP GeneProduct ensembl:ENSG00000214114 ensembl:ENSG00000214114 ncbigene:26292 hgnc.symbol:MYCBP uniprot:Q99417;uniprot:A0A0D9SEI7 -NCOR1 GeneProduct ensembl:ENSG00000141027 Which NCOR not specified ensembl:ENSG00000141027 ncbigene:9611 hgnc.symbol:NCOR1 uniprot:E7EVK1;uniprot:J3KRE4;uniprot:A0A024RD47;uniprot:J3QKP0;uniprot:C9JAP0;uniprot:S4R380;uniprot:O75376;uniprot:E7EW50;uniprot:J3KS51;uniprot:J3KT44;uniprot:E7EVU5;uniprot:H0Y459;uniprot:J3KS29 -MYC GeneProduct hgnc.symbol:MYC ensembl:ENSG00000136997 ncbigene:4609 hgnc.symbol:MYC uniprot:H0YBG3;uniprot:H0YBT0;uniprot:Q16591;uniprot:A0A494C1T8;uniprot:Q14899;uniprot:A0A0B4J1R1;uniprot:P01106;uniprot:A0A024R9L7;uniprot:A0A087WUS5 -MYCN GeneProduct ensembl:ENSG00000134323 ensembl:ENSG00000134323 ncbigene:4613 hgnc.symbol:MYCN uniprot:P04198;uniprot:A0A1W2PPD9 -CEBPA GeneProduct ensembl:ENSG00000245848 CEBP Not Specified ensembl:ENSG00000245848 ncbigene:1050 hgnc.symbol:CEBPA uniprot:P49715 -MGA GeneProduct ensembl:ENSG00000174197 ensembl:ENSG00000174197 ncbigene:23269 hgnc.symbol:MGA uniprot:H3BU53;uniprot:Q8IWI9;uniprot:H3BP52 -MAX GeneProduct ensembl:ENSG00000125952 ensembl:ENSG00000125952 ncbigene:4149 hgnc.symbol:MAX uniprot:P61244;uniprot:G3V570;uniprot:A0A024R682;uniprot:G3V563;uniprot:A0A494C130;uniprot:G3V2R5;uniprot:G3V302;uniprot:G3V2N4;uniprot:Q6V3B1;uniprot:G3V5L1 -SMARCA2 GeneProduct ensembl:ENSG00000080503 ensembl:ENSG00000080503 ncbigene:6595 hgnc.symbol:SMARCA2 uniprot:A0A0U1RQW7;uniprot:A0A0U1RR45;uniprot:F6XE55;uniprot:A0A0U1RR26;uniprot:A0A0U1RR09;uniprot:A0A0U1RQE1;uniprot:B1ALF6;uniprot:F6VDE0;uniprot:A0A0U1RRG6;uniprot:A0A1B0GTC9;uniprot:A0A1W2PS06;uniprot:A0A0U1RQX3;uniprot:A0A1B0GWA8;uniprot:P51531;uniprot:A0A0U1RQZ9;uniprot:A0A0U1RQP3;uniprot:F6T8Q0;uniprot:A0A0U1RRN2;uniprot:A0A1B0GUV6;uniprot:A0A1B0GU54;uniprot:B4DNT1;uniprot:F6RS74;uniprot:A0A0U1RRJ4;uniprot:A0A0U1RRJ8;uniprot:A0A0A0MT03;uniprot:A0A0U1RRF5;uniprot:B1ALG2;uniprot:F6UH26;uniprot:A0A0A0MSS5;uniprot:A0A0U1RRD6;uniprot:A0A0U1RRF8;uniprot:B1ALG1;uniprot:A0A0U1RQU0;uniprot:A0A0U1RR83;uniprot:A0A0U1RQS1 -IL17RD GeneProduct ensembl:ENSG00000144730 ensembl:ENSG00000144730 ncbigene:54756 hgnc.symbol:IL17RD uniprot:C9J6R0;uniprot:Q8NFM7 -FGF16 GeneProduct ensembl:ENSG00000196468 ensembl:ENSG00000196468 ncbigene:8823 hgnc.symbol:FGF16 uniprot:O43320 -ERBB2IP GeneProduct ensembl:ENSG00000112851 ensembl:ENSG00000112851 ncbigene:55914 hgnc.symbol:ERBIN uniprot:B4DIP2;uniprot:H0Y9E8;uniprot:Q96RT1;uniprot:H0YA04 -FGFR4 GeneProduct ensembl:ENSG00000160867 ensembl:ENSG00000160867 ncbigene:2264 hgnc.symbol:FGFR4 uniprot:D6RJD4;uniprot:B5A964;uniprot:H0Y9P2;uniprot:D6RG06;uniprot:J3KPQ0;uniprot:E7EWF4;uniprot:D6R9V0;uniprot:P22455 -INSRR GeneProduct ensembl:ENSG00000027644 ensembl:ENSG00000027644 ncbigene:3645 hgnc.symbol:INSRR uniprot:P14616 -PIK3CA GeneProduct ensembl:ENSG00000121879 ensembl:ENSG00000121879 ncbigene:5290 hgnc.symbol:PIK3CA uniprot:A0A2R8Y2F6;uniprot:C9JAM9;uniprot:A0A6Q8PGN9;uniprot:A0A6Q8PGV1;uniprot:C9J951;uniprot:P42336 -ERBB2 GeneProduct ensembl:ENSG00000141736 ERBB Not Specified ensembl:ENSG00000141736 ncbigene:2064 hgnc.symbol:ERBB2 uniprot:J3QL83;uniprot:J3QLV2;uniprot:J3KRI9;uniprot:F5H1T4;uniprot:J3KTI5;uniprot:P04626;uniprot:X5DNK3;uniprot:J3QRJ7;uniprot:J3QLU9;uniprot:J3QRX1;uniprot:B4DTR1 -HRAS GeneProduct ensembl:ENSG00000174775 ensembl:ENSG00000174775 ncbigene:3265 hgnc.symbol:HRAS uniprot:P01112;uniprot:X5D945 -PTEN GeneProduct ensembl:ENSG00000171862 ensembl:ENSG00000171862 ncbigene:5728 hgnc.symbol:PTEN uniprot:P60484;uniprot:A0A087X033;uniprot:F6KD01 -MAGI1 GeneProduct ensembl:ENSG00000151276 ensembl:ENSG00000151276 ncbigene:9223 hgnc.symbol:MAGI1 uniprot:H7C5T8;uniprot:H7C535;uniprot:A0A087WT53;uniprot:H7C4S7;uniprot:H7C4U7;uniprot:Q96QZ7;uniprot:A0A087WXD2 -MAGI2 GeneProduct ensembl:ENSG00000187391 ensembl:ENSG00000187391 ncbigene:9863 hgnc.symbol:MAGI2 uniprot:A0A1B0GVS6;uniprot:A0A0D9SFY9;uniprot:E7EWI0;uniprot:A0A0D9SF86;uniprot:A0A0D9SET0;uniprot:A0A0D9SEZ7;uniprot:A0A1B0GUV4;uniprot:A0A1B0GVS0;uniprot:A0A0D9SEY4;uniprot:A0A1B0GTC0;uniprot:A0A1B0GUF0;uniprot:Q86UL8;uniprot:A0A0U1RRH4;uniprot:A0A0D9SGF8;uniprot:A0A0E3D6M1;uniprot:A0A0D9SGF2;uniprot:A0A1B0GUI9;uniprot:A0A1B0GTH8;uniprot:A0A0D9SGI1;uniprot:A0A0D9SFP3 -RAF1 GeneProduct ensembl:ENSG00000132155 RAF Not Specified ensembl:ENSG00000132155 ncbigene:5894 hgnc.symbol:RAF1 uniprot:A0A0S2Z4L5;uniprot:P04049;uniprot:A0A0S2Z559;uniprot:A0A0B4J1W9;uniprot:H7C155;uniprot:L7RRS6 -AKT1 GeneProduct ensembl:ENSG00000142208 AKT Not Specified ensembl:ENSG00000142208 ncbigene:207 hgnc.symbol:AKT1 uniprot:G3V3X1;uniprot:P31749;uniprot:G3V2I6;uniprot:B0LPE5;uniprot:A0A087WY56 -FOXO3 GeneProduct ensembl:ENSG00000118689 ensembl:ENSG00000118689 ncbigene:2309 hgnc.symbol:FOXO3 uniprot:O43524 -MAP2K2 GeneProduct ensembl:ENSG00000126934 ensembl:ENSG00000126934 ncbigene:5605 hgnc.symbol:MAP2K2 uniprot:P36507;uniprot:M0R1B6 -CNTN6 GeneProduct ensembl:ENSG00000134115 ensembl:ENSG00000134115 ncbigene:27255 hgnc.symbol:CNTN6 uniprot:A1LMA8;uniprot:F8VWS7;uniprot:Q9UQ52;uniprot:F8WDQ0 -NOTCH1 GeneProduct ensembl:ENSG00000148400 ensembl:ENSG00000148400 ncbigene:4851 hgnc.symbol:NOTCH1 uniprot:P46531 -CTBP1 GeneProduct ensembl:ENSG00000159692 CTBP Not Specified ensembl:ENSG00000159692 ncbigene:1487 hgnc.symbol:CTBP1 uniprot:A0A0D9SGE6;uniprot:D6RAX2;uniprot:E9PGB1;uniprot:H0Y913;uniprot:X5D8Y5;uniprot:E7EPF8;uniprot:E7ESU7;uniprot:Q13363;uniprot:E7EUB3;uniprot:H0Y8U5;uniprot:H0Y8W7;uniprot:H0Y9M9 -FOXP2 GeneProduct ensembl:ENSG00000128573 ensembl:ENSG00000128573 ncbigene:93986 hgnc.symbol:FOXP2 uniprot:Q75MZ5;uniprot:X5D2H2;uniprot:A0A0U1RQM2;uniprot:A0A0U1RQR8;uniprot:C9JQP8;uniprot:A0A0U1RQE0;uniprot:A8MUV4;uniprot:F8WDL6;uniprot:A8MTU2;uniprot:A0A0U1RQE6;uniprot:O15409;uniprot:Q8N6B5;uniprot:A0A0U1RQY3;uniprot:Q0PRL4 -DTX4 GeneProduct ensembl:ENSG00000110042 ensembl:ENSG00000110042 ncbigene:23220 hgnc.symbol:DTX4 uniprot:Q9Y2E6 -FBXW7 GeneProduct ensembl:ENSG00000109670 ensembl:ENSG00000109670 ncbigene:55294 hgnc.symbol:FBXW7 uniprot:S4R3U4;uniprot:Q969H0;uniprot:G0Z2K0;uniprot:S4R3N3 -MYCN GeneProduct ensembl:ENSG00000134323 ensembl:ENSG00000134323 ncbigene:4613 hgnc.symbol:MYCN uniprot:P04198;uniprot:A0A1W2PPD9 -MAML3 GeneProduct ensembl:ENSG00000196782 ensembl:ENSG00000196782 ncbigene:55534 hgnc.symbol:MAML3 uniprot:Q96JK9;uniprot:H0Y920 -NICD GeneProduct ensembl:ENSG00000148400 Using NOTCH identifier for NICD (Notch Intercellular Domain)
Type your comment here ensembl:ENSG00000148400 ncbigene:4851 hgnc.symbol:NOTCH1 uniprot:P46531 -Chk1 Protein uniprot:E7EPP6 ensembl:ENSG00000149554 ncbigene:1111 hgnc.symbol:CHEK1 uniprot:E9PJI4;uniprot:A0A087WT52;uniprot:E7EPP6;uniprot:E9PKQ3;uniprot:O14757;uniprot:E9PPA5;uniprot:E9PRU7;uniprot:E9PQW7 -Chk2 Protein uniprot:C9JFD7 ensembl:ENSG00000183765 ncbigene:11200 hgnc.symbol:CHEK2 uniprot:A0A3B3ITA7;uniprot:A0A087X102;uniprot:H7BZ30;uniprot:O96017;uniprot:C9JFD7;uniprot:H0Y820;uniprot:F8WCV2;uniprot:H7C0V7;uniprot:B7ZBF2;uniprot:B7ZBF8;uniprot:B7ZBF7;uniprot:H0Y4V6 +Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps +HIST1H1E GeneProduct ensembl:ENSG00000168298 "" ensembl:ENSG00000168298 ncbigene:3008 hgnc.symbol:H1-4 uniprot:A3R0T8;uniprot:P10412 +HIST1H2AL GeneProduct ensembl:ENSG00000276903 "" ensembl:ENSG00000276903 ncbigene:8332 hgnc.symbol:H2AC16 uniprot:A4FTV9;uniprot:P0C0S8 +PRKDC GeneProduct ensembl:ENSG00000253729 "" ensembl:ENSG00000253729 ncbigene:5591 hgnc.symbol:PRKDC uniprot:F5GX40;uniprot:H0YG84;uniprot:P78527 +BRD1 GeneProduct ensembl:ENSG00000100425 "" ensembl:ENSG00000100425 ncbigene:23774 hgnc.symbol:BRD1 uniprot:J3KQ61;uniprot:A0A024R4W4;uniprot:A0A024R4V5;uniprot:O95696 +SMARCE1 GeneProduct ensembl:ENSG00000073584 "" ensembl:ENSG00000073584 ncbigene:6605 hgnc.symbol:SMARCE1 uniprot:B4DGM3;uniprot:A0A2R8Y7I9;uniprot:A0A2R8YDQ4;uniprot:J3QKS7;uniprot:A0A2R8YD78;uniprot:A0A2R8YES3;uniprot:J3QR61;uniprot:J3QL66;uniprot:J3QKX6;uniprot:J3KT85;uniprot:J3QS32;uniprot:A0A2U3TZQ7;uniprot:A0A2R8Y765;uniprot:A0A2R8Y7U4;uniprot:A0A024R1S7;uniprot:A0A2R8Y4T4;uniprot:A0A2R8YEB8;uniprot:A0A2R8YFC8;uniprot:A0A2R8YDD9;uniprot:Q969G3;uniprot:A0A2R8Y855 +NFIB GeneProduct ensembl:ENSG00000147862 "" ensembl:ENSG00000147862 ncbigene:4781 hgnc.symbol:NFIB uniprot:U3KPY9;uniprot:O00712;uniprot:Q5VW28;uniprot:Q5VW26;uniprot:A0A1B0GU97;uniprot:Q5VW27;uniprot:A0A1B0GTC1;uniprot:A0A1B0GWJ4;uniprot:A0A1B0GVN4;uniprot:A0A1B0GW37;uniprot:Q5W0Y9;uniprot:A0A1B0GWI9;uniprot:U3KQE8;uniprot:A0A0A0MRX8;uniprot:Q5VW31;uniprot:A0A1B0GWB8;uniprot:A0A2R8Y7V8;uniprot:Q5VW30 +DTX4 GeneProduct ensembl:ENSG00000110042 "" ensembl:ENSG00000110042 ncbigene:23220 hgnc.symbol:DTX4 uniprot:Q9Y2E6 +ATM GeneProduct ensembl:ENSG00000149311 "" ensembl:ENSG00000149311 ncbigene:472 hgnc.symbol:ATM uniprot:E9PIN0;uniprot:Q6P7P1;uniprot:Q13315;uniprot:A0A804HL86;uniprot:H0YDU7;uniprot:A0A087X0E9;uniprot:A0A6Q8PH76;uniprot:M0QXY8;uniprot:H0YEC6;uniprot:A0A024R3C7;uniprot:E9PRG7 +CNTN6 GeneProduct ensembl:ENSG00000134115 "" ensembl:ENSG00000134115 ncbigene:27255 hgnc.symbol:CNTN6 uniprot:A1LMA8;uniprot:F8VWS7;uniprot:Q9UQ52;uniprot:F8WDQ0 +ARID4B GeneProduct ensembl:ENSG00000054267 "" ensembl:ENSG00000054267 ncbigene:51742 hgnc.symbol:ARID4B uniprot:H7C5R6;uniprot:X6RCR8;uniprot:H0Y7Y8;uniprot:Q4LE39 +MYCBP GeneProduct ensembl:ENSG00000214114 "" ensembl:ENSG00000214114 ncbigene:26292 hgnc.symbol:MYCBP uniprot:Q99417;uniprot:A0A0D9SEI7 +MYCN GeneProduct ensembl:ENSG00000134323 "" ensembl:ENSG00000134323 ncbigene:4613 hgnc.symbol:MYCN uniprot:P04198;uniprot:A0A1W2PPD9 +MORF4L1 GeneProduct ensembl:ENSG00000185787 "" ensembl:ENSG00000185787 ncbigene:10933 hgnc.symbol:MORF4L1 uniprot:B3KTM8;uniprot:Q9UBU8;uniprot:H0YMT8;uniprot:H0YNI8;uniprot:H0YM21;uniprot:H0YLV1;uniprot:H0YNE0;uniprot:H0YNX3;uniprot:H0YMJ0;uniprot:H0YLJ3 +ERBB2 GeneProduct ensembl:ENSG00000141736 "ERBB Not Specified" ensembl:ENSG00000141736 ncbigene:2064 hgnc.symbol:ERBB2 uniprot:J3QL83;uniprot:J3QLV2;uniprot:J3KRI9;uniprot:F5H1T4;uniprot:J3KTI5;uniprot:P04626;uniprot:X5DNK3;uniprot:J3QRJ7;uniprot:J3QLU9;uniprot:J3QRX1;uniprot:B4DTR1 +FBXW7 GeneProduct ensembl:ENSG00000109670 "" ensembl:ENSG00000109670 ncbigene:55294 hgnc.symbol:FBXW7 uniprot:S4R3U4;uniprot:Q969H0;uniprot:G0Z2K0;uniprot:S4R3N3 +HRAS GeneProduct ensembl:ENSG00000174775 "" ensembl:ENSG00000174775 ncbigene:3265 hgnc.symbol:HRAS uniprot:P01112;uniprot:A0A804HKM6;uniprot:X5D945;uniprot:A0A804HJ06;uniprot:A0A8C8MQR2 +SMARCA2 GeneProduct ensembl:ENSG00000080503 "" ensembl:ENSG00000080503 ncbigene:6595 hgnc.symbol:SMARCA2 uniprot:A0A0U1RQW7;uniprot:A0A0U1RR45;uniprot:F6XE55;uniprot:A0A0U1RR26;uniprot:A0A0U1RR09;uniprot:A0A0U1RQE1;uniprot:B1ALF6;uniprot:F6VDE0;uniprot:A0A0U1RRG6;uniprot:A0A1B0GTC9;uniprot:A0A1W2PS06;uniprot:A0A0U1RQX3;uniprot:A0A1B0GWA8;uniprot:P51531;uniprot:A0A0U1RQZ9;uniprot:A0A0U1RQP3;uniprot:F6T8Q0;uniprot:A0A0U1RRN2;uniprot:A0A1B0GUV6;uniprot:A0A1B0GU54;uniprot:B4DNT1;uniprot:F6RS74;uniprot:A0A0U1RRJ4;uniprot:A0A0U1RRJ8;uniprot:A0A0A0MT03;uniprot:A0A0U1RRF5;uniprot:B1ALG2;uniprot:F6UH26;uniprot:A0A0A0MSS5;uniprot:A0A0U1RRD6;uniprot:A0A0U1RRF8;uniprot:B1ALG1;uniprot:A0A0U1RQU0;uniprot:A0A0U1RR83;uniprot:A0A0U1RQS1 +FOXP2 GeneProduct ensembl:ENSG00000128573 "" ensembl:ENSG00000128573 ncbigene:93986 hgnc.symbol:FOXP2 uniprot:Q75MZ5;uniprot:X5D2H2;uniprot:A0A0U1RQM2;uniprot:A0A0U1RQR8;uniprot:C9JQP8;uniprot:A0A0U1RQE0;uniprot:A8MUV4;uniprot:F8WDL6;uniprot:A8MTU2;uniprot:A0A0U1RQE6;uniprot:O15409;uniprot:Q8N6B5;uniprot:A0A0U1RQY3;uniprot:Q0PRL4 +MYBL1 GeneProduct ensembl:ENSG00000185697 "" ensembl:ENSG00000185697 ncbigene:4603 hgnc.symbol:MYBL1 uniprot:E7EWZ1;uniprot:P10243 +TP53 GeneProduct ensembl:ENSG00000141510 "" ensembl:ENSG00000141510 ncbigene:7157 hgnc.symbol:TP53 uniprot:E9PFT5;uniprot:A0A087WXZ1;uniprot:P04637;uniprot:A0A087X1Q1;uniprot:E7ESS1;uniprot:E7EMR6;uniprot:E7EQX7;uniprot:A0A0U1RQC9;uniprot:J3KP33;uniprot:H2EHT1;uniprot:I3L0W9;uniprot:K7PPA8;uniprot:S4R334;uniprot:A0A087WT22;uniprot:E9PCY9 +MAML3 GeneProduct ensembl:ENSG00000196782 "" ensembl:ENSG00000196782 ncbigene:55534 hgnc.symbol:MAML3 uniprot:Q96JK9;uniprot:H0Y920 +FGFR4 GeneProduct ensembl:ENSG00000160867 "" ensembl:ENSG00000160867 ncbigene:2264 hgnc.symbol:FGFR4 uniprot:D6RJD4;uniprot:B5A964;uniprot:H0Y9P2;uniprot:D6RG06;uniprot:J3KPQ0;uniprot:E7EWF4;uniprot:D6R9V0;uniprot:P22455 +MAGI2 GeneProduct ensembl:ENSG00000187391 "" ensembl:ENSG00000187391 ncbigene:9863 hgnc.symbol:MAGI2 uniprot:A0A1B0GVS6;uniprot:A0A0D9SFY9;uniprot:E7EWI0;uniprot:A0A0D9SF86;uniprot:A0A0D9SET0;uniprot:A0A0D9SEZ7;uniprot:A0A1B0GUV4;uniprot:A0A1B0GVS0;uniprot:A0A0D9SEY4;uniprot:A0A1B0GTC0;uniprot:A0A1B0GUF0;uniprot:Q86UL8;uniprot:A0A0U1RRH4;uniprot:A0A0D9SGF8;uniprot:A0A0E3D6M1;uniprot:A0A0D9SGF2;uniprot:A0A1B0GUI9;uniprot:A0A1B0GTH8;uniprot:A0A0D9SGI1;uniprot:A0A0D9SFP3 +EP300 GeneProduct ensembl:ENSG00000100393 "" ensembl:ENSG00000100393 ncbigene:2033 hgnc.symbol:EP300 uniprot:A0A0U1RR87;uniprot:A0A669KB12;uniprot:Q09472 +MYC GeneProduct hgnc.symbol:MYC "" ensembl:ENSG00000136997 ncbigene:4609 hgnc.symbol:MYC uniprot:H0YBG3;uniprot:H0YBT0;uniprot:Q16591;uniprot:A0A494C1T8;uniprot:Q14899;uniprot:A0A0B4J1R1;uniprot:P01106;uniprot:A0A024R9L7;uniprot:A0A087WUS5 +JMJD1C GeneProduct ensembl:ENSG00000171988 "" ensembl:ENSG00000171988 ncbigene:221037 hgnc.symbol:JMJD1C uniprot:H7BXU7;uniprot:Q15652 +CMTR2 GeneProduct ensembl:ENSG00000180917 "" ensembl:ENSG00000180917 ncbigene:55783 hgnc.symbol:CMTR2 uniprot:H3BTZ7;uniprot:H3BS00;uniprot:Q8IYT2;uniprot:H3BNZ8;uniprot:H3BUK2;uniprot:H3BR19 +BCORL1 GeneProduct ensembl:ENSG00000085185 "" ensembl:ENSG00000085185 ncbigene:63035 hgnc.symbol:BCORL1 uniprot:Q5H9F3;uniprot:H7C4B2;uniprot:V9GYD4;uniprot:A0A087X1F0 +MGA GeneProduct ensembl:ENSG00000174197 "" ensembl:ENSG00000174197 ncbigene:23269 hgnc.symbol:MGA uniprot:H3BU53;uniprot:Q8IWI9;uniprot:H3BP52;uniprot:A0A8C8P5L8 +ERBB2IP GeneProduct ensembl:ENSG00000112851 "" ensembl:ENSG00000112851 ncbigene:55914 hgnc.symbol:ERBIN uniprot:B4DIP2;uniprot:Q96RT1;uniprot:H0YA04 +MAGI1 GeneProduct ensembl:ENSG00000151276 "" ensembl:ENSG00000151276 ncbigene:9223 hgnc.symbol:MAGI1 uniprot:H7C5T8;uniprot:H7C535;uniprot:A0A087WT53;uniprot:H7C4S7;uniprot:H7C4U7;uniprot:Q96QZ7;uniprot:A0A087WXD2 +KAT6A GeneProduct ensembl:ENSG00000083168 "" ensembl:ENSG00000083168 ncbigene:7994 hgnc.symbol:KAT6A uniprot:A0A3B3ITI3;uniprot:Q92794;uniprot:A0A3B3ISZ3;uniprot:A5PLL3;uniprot:A0A3F2YNX6;uniprot:A0A3B3ISU5;uniprot:A0A3B3IS53;uniprot:C9JJY6 +SMC1A GeneProduct ensembl:ENSG00000072501 "" ensembl:ENSG00000072501 ncbigene:8243 hgnc.symbol:SMC1A uniprot:A0A384MR33;uniprot:V9GYN9;uniprot:A0A6Q8PHC3;uniprot:Q14683;uniprot:G8JLG1;uniprot:V9GY57 +CEBPA GeneProduct ensembl:ENSG00000245848 "CEBP Not Specified" ensembl:ENSG00000245848 ncbigene:1050 hgnc.symbol:CEBPA uniprot:P49715 +CREBBP GeneProduct ensembl:ENSG00000005339 "" ensembl:ENSG00000005339 ncbigene:1387 hgnc.symbol:CREBBP uniprot:Q92793;uniprot:I3L466;uniprot:A0A1B0GUU0;uniprot:I3L3I5;uniprot:I3L0Q1;uniprot:I3L293 +PIK3CA GeneProduct ensembl:ENSG00000121879 "" ensembl:ENSG00000121879 ncbigene:5290 hgnc.symbol:PIK3CA uniprot:A0A2R8Y2F6;uniprot:C9JAM9;uniprot:A0A6Q8PGN9;uniprot:A0A6Q8PGV1;uniprot:C9J951;uniprot:P42336 +UHRF1 GeneProduct ensembl:ENSG00000276043 "" ensembl:ENSG00000276043 ncbigene:29128 hgnc.symbol:UHRF1 uniprot:A0A087WTW0;uniprot:A0A087WWG9;uniprot:Q96T88;uniprot:A0A087WVR3 +ATRX GeneProduct ensembl:ENSG00000085224 "" ensembl:ENSG00000085224 ncbigene:546 hgnc.symbol:ATRX uniprot:A0A096LNW1;uniprot:P46100;uniprot:A0A096LPG6;uniprot:A0A096LNL9;uniprot:A0A6Q8PHA4;uniprot:H0Y3T0;uniprot:A0A096LNL6;uniprot:A0A096LNL7;uniprot:A0A096LNN3;uniprot:A0A096LNR8;uniprot:A0A096LP59;uniprot:A0A087WWG0;uniprot:A4LAA3;uniprot:A0A096LNX6 +KDM6B GeneProduct ensembl:ENSG00000132510 "" ensembl:ENSG00000132510 ncbigene:23135 hgnc.symbol:KDM6B uniprot:I3L0Z0;uniprot:O15054 +MYB GeneProduct ensembl:ENSG00000118513 "" ensembl:ENSG00000118513 ncbigene:4602 hgnc.symbol:MYB uniprot:E9PJ96;uniprot:E9PN92;uniprot:E9PJT2;uniprot:E9PLN0;uniprot:E9PPR4;uniprot:F8W8G5;uniprot:E9PMZ0;uniprot:E9PKZ3;uniprot:P10242;uniprot:Q708E3;uniprot:E9PIW4;uniprot:Q708E5;uniprot:E9PMQ0;uniprot:Q708E6;uniprot:E9PP87;uniprot:Q708E9;uniprot:Q708E8;uniprot:E9PN43;uniprot:A0A0C4DG19;uniprot:E9PQQ2;uniprot:E9PJF1;uniprot:A0A087WTI6;uniprot:H0YCN6;uniprot:E9PNH6;uniprot:E9PPL8 +RAF1 GeneProduct ensembl:ENSG00000132155 "RAF Not Specified" ensembl:ENSG00000132155 ncbigene:5894 hgnc.symbol:RAF1 uniprot:A0A0S2Z4L5;uniprot:P04049;uniprot:A0A0S2Z559;uniprot:A0A0B4J1W9;uniprot:H7C155;uniprot:L7RRS6 +PTEN GeneProduct ensembl:ENSG00000171862 "" ensembl:ENSG00000171862 ncbigene:5728 hgnc.symbol:PTEN uniprot:P60484;uniprot:A0A087X033;uniprot:F6KD01 +TLK1 GeneProduct ensembl:ENSG00000198586 "" ensembl:ENSG00000198586 ncbigene:9874 hgnc.symbol:TLK1 uniprot:F8W7X8;uniprot:C9JWT6;uniprot:Q9UKI8;uniprot:B3KRP1 +NSD1 GeneProduct ensembl:ENSG00000165671 "" ensembl:ENSG00000165671 ncbigene:64324 hgnc.symbol:NSD1 uniprot:D6RG26;uniprot:Q96L73;uniprot:H7BYB0;uniprot:D6RA58;uniprot:A0A1W2PS55;uniprot:D6RE14;uniprot:D6RBP3 +KMT2C GeneProduct ensembl:ENSG00000055609 "" ensembl:ENSG00000055609 ncbigene:58508 hgnc.symbol:KMT2C uniprot:A0A804HJV8;uniprot:Q8NEZ4;uniprot:A0A7P0T9N3;uniprot:A0A804HJT1;uniprot:A0A804HJ77;uniprot:H7C212;uniprot:H7C2V8;uniprot:A0A804HIF3;uniprot:A0A804HJR9;uniprot:A0A7P0T8F0;uniprot:A0A804HKJ1;uniprot:A0A7P0TAI3;uniprot:A0A7P0TBM6;uniprot:A0A7P0TAQ8;uniprot:A0A804HLA5;uniprot:H7BY37;uniprot:A0A7P0T9U9;uniprot:A0A804HKS3;uniprot:A0A7P0T9Q7;uniprot:A0A804HIM1;uniprot:A0A804HKQ3;uniprot:A0A7P0TA60;uniprot:A0A804HIW6;uniprot:A0A804HKW4;uniprot:A0A804HIS4;uniprot:A0A804HJU5;uniprot:C9J4Z5;uniprot:A0A804HIG3;uniprot:A0A7P0T9K8;uniprot:A0A804HJ27;uniprot:A0A804HK48;uniprot:A0A804HI08;uniprot:A0A804HIK3;uniprot:A0A804HIM6;uniprot:A0A804HLD4;uniprot:A0A7P0Z448;uniprot:H0Y765;uniprot:H0YNL4;uniprot:A0A804HHW0 +KDM6A GeneProduct ensembl:ENSG00000147050 "" ensembl:ENSG00000147050 ncbigene:7403 hgnc.symbol:KDM6A uniprot:A0A087X0R0;uniprot:O15550;uniprot:A0A6Q8PHJ0;uniprot:F8W8R6;uniprot:A0A6Q8PFD0;uniprot:F5H6S1;uniprot:F5H5V6;uniprot:A0A804HLJ3;uniprot:A0A6Q8PGG6;uniprot:A0A6Q8PHB6;uniprot:H0Y6I7;uniprot:A0A087WUN6;uniprot:A0A804HJA2;uniprot:A0A6Q8PG92;uniprot:A0A6Q8PH94;uniprot:A0A6Q8PGN0;uniprot:A0A6Q8PG32;uniprot:A0A804HIZ7;uniprot:A0A6Q8PFK0;uniprot:H0Y6V5 +AKT1 GeneProduct ensembl:ENSG00000142208 "AKT Not Specified" ensembl:ENSG00000142208 ncbigene:207 hgnc.symbol:AKT1 uniprot:G3V3X1;uniprot:P31749;uniprot:G3V2I6;uniprot:A0A804HJM6;uniprot:B0LPE5;uniprot:A0A087WY56 +KANSL1 GeneProduct ensembl:ENSG00000120071 "" ensembl:ENSG00000120071 ncbigene:284058 hgnc.symbol:KANSL1 uniprot:A0A1W2PS83;uniprot:Q7Z3B3;uniprot:A0A1W2PRA9;uniprot:A0A024R9Y2;uniprot:A0A0G2JQP8;uniprot:A0A1W2PRR3;uniprot:I3L233;uniprot:A0A3B3IT55;uniprot:A0A1W2PRB5;uniprot:A0A1W2PPV8;uniprot:A0A1W2PQT4 +BCOR GeneProduct ensembl:ENSG00000183337 "" ensembl:ENSG00000183337 ncbigene:54880 hgnc.symbol:BCOR uniprot:Q6W2J9;uniprot:A0A5F9ZGX7;uniprot:H7C2V9;uniprot:H7BYY2;uniprot:C9JHP3;uniprot:H7BZ37;uniprot:H7C231;uniprot:A1A564 +FOXO3 GeneProduct ensembl:ENSG00000118689 "" ensembl:ENSG00000118689 ncbigene:2309 hgnc.symbol:FOXO3 uniprot:O43524;uniprot:A0A856PRE8 +FGF16 GeneProduct ensembl:ENSG00000196468 "" ensembl:ENSG00000196468 ncbigene:8823 hgnc.symbol:FGF16 uniprot:O43320;uniprot:A0A7U3L5H2 +MAX GeneProduct ensembl:ENSG00000125952 "" ensembl:ENSG00000125952 ncbigene:4149 hgnc.symbol:MAX uniprot:P61244;uniprot:G3V570;uniprot:A0A024R682;uniprot:G3V563;uniprot:A0A494C130;uniprot:G3V2R5;uniprot:G3V302;uniprot:G3V2N4;uniprot:Q6V3B1;uniprot:G3V5L1 +SETD2 GeneProduct ensembl:ENSG00000181555 "" ensembl:ENSG00000181555 ncbigene:29072 hgnc.symbol:SETD2 uniprot:H7BXT4;uniprot:H7BZ93;uniprot:Q9BYW2;uniprot:H7C3H4;uniprot:C9JG86;uniprot:A0A1W2PPX9 +CTBP1 GeneProduct ensembl:ENSG00000159692 "CTBP Not Specified" ensembl:ENSG00000159692 ncbigene:1487 hgnc.symbol:CTBP1 uniprot:A0A0D9SGE6;uniprot:D6RAX2;uniprot:E9PGB1;uniprot:H0Y913;uniprot:X5D8Y5;uniprot:E7ESU7;uniprot:Q13363;uniprot:E7EUB3;uniprot:H0Y8U5;uniprot:H0Y8W7;uniprot:H0Y9M9 +NOTCH1 GeneProduct ensembl:ENSG00000148400 "" ensembl:ENSG00000148400 ncbigene:4851 hgnc.symbol:NOTCH1 uniprot:A0A7P0TAK8;uniprot:A0A7P0TBG2;uniprot:A0A7P0T8U6;uniprot:A0A7P0T9V1;uniprot:A0A7P0TA56;uniprot:P46531;uniprot:A0A7P0TB20;uniprot:A0A7P0T8W1;uniprot:A0A7P0Z4H9 +INSRR GeneProduct ensembl:ENSG00000027644 "" ensembl:ENSG00000027644 ncbigene:3645 hgnc.symbol:INSRR uniprot:P14616 +MAP2K2 GeneProduct ensembl:ENSG00000126934 "" ensembl:ENSG00000126934 ncbigene:5605 hgnc.symbol:MAP2K2 uniprot:P36507;uniprot:M0R1B6 +SRCAP GeneProduct ensembl:ENSG00000080603 "" ensembl:ENSG00000080603 ncbigene:10847 hgnc.symbol:SRCAP uniprot:A0A087X0E3;uniprot:C9J4U4;uniprot:Q6ZRS2 +BRCA1 GeneProduct ensembl:ENSG00000012048 "" ensembl:ENSG00000012048 ncbigene:672 hgnc.symbol:BRCA1 uniprot:C6YB45;uniprot:Q3B891;uniprot:C9IZW4;uniprot:A0A0A0MSN1;uniprot:E7EQW4;uniprot:P38398;uniprot:A0A494C182;uniprot:A0A0U1RRA9;uniprot:A0A2R8Y7V5;uniprot:B7ZA85;uniprot:H0Y850;uniprot:K7EPC7;uniprot:E7EUM2;uniprot:E7EWN5;uniprot:G1UI37;uniprot:E7ENB7;uniprot:E9PH68;uniprot:A0A024R1V0;uniprot:H0Y8B8;uniprot:A0A024R1Z8;uniprot:H0Y8D8;uniprot:A0A2R8Y6Y9;uniprot:K7EJW3;uniprot:Q5YLB2;uniprot:A0A2R8Y587;uniprot:E9PC22 +CDC2 GeneProduct ncbiprotein:78070384 "" +ARID5B GeneProduct ensembl:ENSG00000150347 "" ensembl:ENSG00000150347 ncbigene:84159 hgnc.symbol:ARID5B uniprot:A0A7P0TAD2;uniprot:Q14865;uniprot:A0A2R8Y5F2 +NCOR1 GeneProduct ensembl:ENSG00000141027 "Which NCOR not specified" ensembl:ENSG00000141027 ncbigene:9611 hgnc.symbol:NCOR1 uniprot:E7EVK1;uniprot:J3KRE4;uniprot:A0A024RD47;uniprot:J3QKP0;uniprot:C9JAP0;uniprot:S4R380;uniprot:O75376;uniprot:E7EW50;uniprot:J3KS51;uniprot:J3KT44;uniprot:E7EVU5;uniprot:H0Y459;uniprot:J3KS29 +ARID1A GeneProduct ensembl:ENSG00000117713 "" ensembl:ENSG00000117713 ncbigene:8289 hgnc.symbol:ARID1A uniprot:A0A1B0GVT5;uniprot:O14497;uniprot:A0A1B0GTU5;uniprot:E9PQW6;uniprot:H0YEW5;uniprot:H0Y488;uniprot:H0YCU6 +IL17RD GeneProduct ensembl:ENSG00000144730 "" ensembl:ENSG00000144730 ncbigene:54756 hgnc.symbol:IL17RD uniprot:C9J6R0;uniprot:Q8NFM7 +NICD GeneProduct ensembl:ENSG00000148400 "Using NOTCH identifier for NICD (Notch Intercellular Domain)" ensembl:ENSG00000148400 ncbigene:4851 hgnc.symbol:NOTCH1 uniprot:A0A7P0TAK8;uniprot:A0A7P0TBG2;uniprot:A0A7P0T8U6;uniprot:A0A7P0T9V1;uniprot:A0A7P0TA56;uniprot:P46531;uniprot:A0A7P0TB20;uniprot:A0A7P0T8W1;uniprot:A0A7P0Z4H9 +Chk1 Protein uniprot:E7EPP6 "" ensembl:ENSG00000149554 ncbigene:1111 hgnc.symbol:CHEK1 uniprot:E9PJI4;uniprot:A0A087WT52;uniprot:E7EPP6;uniprot:E9PKQ3;uniprot:O14757;uniprot:E9PPA5;uniprot:E9PRU7;uniprot:E9PQW7 +Chk2 Protein uniprot:C9JFD7 "" ensembl:ENSG00000183765 ncbigene:11200 hgnc.symbol:CHEK2 uniprot:A0A3B3ITA7;uniprot:A0A087X102;uniprot:H7BZ30;uniprot:A0A7P0MUT5;uniprot:O96017;uniprot:C9JFD7;uniprot:H7C0V7;uniprot:B7ZBF2;uniprot:B7ZBF8;uniprot:B7ZBF7;uniprot:H0Y820;uniprot:F8WCV2;uniprot:H0Y4V6 diff --git a/pathways/WP3651/WP3651.gpml b/pathways/WP3651/WP3651.gpml index b5a416892..bc60484ca 100644 --- a/pathways/WP3651/WP3651.gpml +++ b/pathways/WP3651/WP3651.gpml @@ -1,335 +1,335 @@ - + Protein pathways altered by mutations in adenoid cystic carcinoma. Pathways include epigentic modification, DNA damage checkpoint signals, MYB/MYC signalling pathway, FGF/IGF/PI3K signalling, and notch signalling. In the epigenetic modification pathway, several complexes promote the activity of HIST1H1E/HIST1H2AL which regulate chromatin remodeling. In the DNA damage pathway DNA damage in the nucleus signals to ATM and PRKDC to induce DNA repair and suspend the cell cycle. ATM further activates proteins that induce either apoptosis or DNA repair and leads to the activation of proteins that inhibit progression in the cell cycle. The MYB/MYC pathway involves the activation of protein complexes involved in inducing cell growth and proliferation by CREBBP and MYCBP. However this pathway has feedback inhibition by the binding of the MYBL1/MYB complex to NFIB which depresses MYB activity. The FGF/IGF/PI3K signalling pathway involves the activation of the FGFR4/INSRR complex by FGF16 and ERBB2 activation by ERBB2IP which leads to a signalling cascade that inhibits apoptosis and promotes cell growth and migration. The notch pathway is activated by the biding of CNTN6 to Notch leading to pathway activation. This pathway is regulated by RoxP2, CTBP1, and DTX4/FBXW7. These pathways are from figure 4 from Ho et al. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3651 CPTAC Assay Portal] d82 - - - - - - - - - - - - - - - - - - - - - - - + + + - - - + + + - - - + + + - - - + + + - - - + + Cell Cycle (Homo sapiens) + + - - - + + + - - - + + + - - - + + + - - - + + + - - - - - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + S Phase (Homo sapiens) + + - - - + + ERBB Not Specified + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - - - - - - - - - - - - - - - - - - - - - + + Apoptosis (Homo sapiens) + + - - - + + + - - - + + Cell Cycle (Homo sapiens) + + - - - + + + - - - + + + - - Which NCOR not specified - - + + + - - - + + + - - CEBP Not Specified - - + + + + + + + + + + Mismatch Repair (Homo sapiens) + + - - - + + + - - + + + + + + - - - + + + - - - + + + - - - + + CEBP Not Specified + + - - - + + Pathway Identifier Not Found + + - - - + + + - - ERBB Not Specified - - + + + - - - + + + - - - + + + - - - + + + - - - + + + RAF Not Specified + + + + + + + + + + + + + + + + + + + + AKT Not Specified + + + + + + + + + + + + - - - + + + - - - + + + - - - + + + CTBP Not Specified - - - + + + - - - + + + - - - + + + + + + + + + + + + + + + + + + + - - - + + + - - - + + Which NCOR not specified + + + + + + Chromatin modifying enzymes (Homo sapiens) - - Cell Cycle (Homo sapiens) - - - - - Mismatch Repair (Homo sapiens) - - - - - Apoptosis (Homo sapiens) - - - - - S Phase (Homo sapiens) - - - - - - - - - Cell Cycle (Homo sapiens) - - + + + - - Pathway Identifier Not Found - - + + + Mismatch Repair (Homo sapiens) @@ -348,477 +348,481 @@ Proteins on this pathway have targeted assays available via the [https://assays. Using NOTCH identifier for NICD (Notch Intercellular Domain) - Type your comment here - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - + + + + - - - - + + + + - + - - + + - + - - + + - - - - + + + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + + - + - - - + + - + - - + + - + - - + + - + - - + + - + - - + + - + - - + + - - - - + + + + - - - - + + + + - - - - + + + + - - - - + + + + - - - - + + + + - + - - + + - + diff --git a/pathways/WP3651/WP3651.json b/pathways/WP3651/WP3651.json index 2521f4c29..f5b75b755 100644 --- a/pathways/WP3651/WP3651.json +++ b/pathways/WP3651/WP3651.json @@ -1,27 +1,5 @@ { "entitiesById": { - "740127": { - "__HighlandStream__": true, - "_can_drain": false, - "_consume_waiting_for_next": false, - "_consumers": [], - "_delegate": null, - "_destructors": [], - "_events": {}, - "_eventsCount": 2, - "_in_consume_cb": false, - "_incoming": [], - "_is_observer": false, - "_nil_pushed": false, - "_observers": [], - "_outgoing": [], - "_repeat_resume": false, - "_send_events": false, - "id": "740127", - "paused": true, - "source": null, - "writable": true - }, "a0b8c": { "drawAs": "rect", "fill": "#ffffff", @@ -32,7 +10,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a0b8c", - "isPartOf": "cac23", + "isPartOf": "f29c2", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -76,7 +54,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a13cc", - "isPartOf": "cac23", + "isPartOf": "f29c2", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -164,7 +142,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a532d", - "isPartOf": "d9adf", + "isPartOf": "c6dc3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -200,6 +178,39 @@ "y": 128, "zIndex": 32768 }, + "a6ae1": { + "contains": [ + "ff487", + "a73fe", + "ce9f0", + "d37dd", + "f2b49", + "fb2c2" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 136, + "id": "a6ae1", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 193, + "x": 257, + "y": 23, + "zIndex": 28672 + }, "a73fe": { "drawAs": "rect", "fill": "#ffffff", @@ -210,7 +221,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "a73fe", - "isPartOf": "e5865", + "isPartOf": "a6ae1", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -316,7 +327,7 @@ "gpmlElementName": "Label", "height": 20, "id": "a829a", - "isPartOf": "d1d1c", + "isPartOf": "df474", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -503,6 +514,7 @@ "UniProt:E9PIN0", "UniProt:Q6P7P1", "UniProt:Q13315", + "UniProt:A0A804HL86", "UniProt:H0YDU7", "UniProt:A0A087X0E9", "UniProt:A0A6Q8PH76", @@ -566,6 +578,35 @@ "y": 875.75, "zIndex": 32768 }, + "abf8d": { + "contains": [ + "b8d96", + "ddb3a" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "abf8d", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 96, + "x": 133, + "y": 525, + "zIndex": 32768 + }, "b0e90": { "drawAs": "rect", "fill": "#ffffff", @@ -576,7 +617,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b0e90", - "isPartOf": "e39e1", + "isPartOf": "df7af", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -737,14 +778,15 @@ "UniProt:A0A3B3ITA7", "UniProt:A0A087X102", "UniProt:H7BZ30", + "UniProt:A0A7P0MUT5", "UniProt:O96017", "UniProt:C9JFD7", - "UniProt:H0Y820", - "UniProt:F8WCV2", "UniProt:H7C0V7", "UniProt:B7ZBF2", "UniProt:B7ZBF8", "UniProt:B7ZBF7", + "UniProt:H0Y820", + "UniProt:F8WCV2", "UniProt:H0Y4V6" ], "verticalAlign": "middle", @@ -767,7 +809,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b2374", - "isPartOf": "c13f9", + "isPartOf": "efcb3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -805,9 +847,6 @@ "comments": [ { "content": "Using NOTCH identifier for NICD (Notch Intercellular Domain)" - }, - { - "content": "Type your comment here" } ], "drawAs": "rect", @@ -839,7 +878,15 @@ "Ensembl:ENSG00000148400", "Entrez Gene:4851", "HGNC:NOTCH1", - "UniProt:P46531" + "UniProt:A0A7P0TAK8", + "UniProt:A0A7P0TBG2", + "UniProt:A0A7P0T8U6", + "UniProt:A0A7P0T9V1", + "UniProt:A0A7P0TA56", + "UniProt:P46531", + "UniProt:A0A7P0TB20", + "UniProt:A0A7P0T8W1", + "UniProt:A0A7P0Z4H9" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -861,7 +908,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b348f", - "isPartOf": "d9adf", + "isPartOf": "c6dc3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1048,35 +1095,6 @@ "y": 979, "zIndex": 32768 }, - "b4c86": { - "contains": [ - "b8d96", - "ddb3a" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "b4c86", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 96, - "x": 133, - "y": 525, - "zIndex": 32768 - }, "b531a": { "drawAs": "none", "fill": "transparent", @@ -1208,7 +1226,10 @@ "Entrez Gene:3265", "HGNC:HRAS", "UniProt:P01112", - "UniProt:X5D945" + "UniProt:A0A804HKM6", + "UniProt:X5D945", + "UniProt:A0A804HJ06", + "UniProt:A0A8C8MQR2" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1361,7 +1382,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "b8d96", - "isPartOf": "b4c86", + "isPartOf": "abf8d", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1590,7 +1611,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bdfdd", - "isPartOf": "e55b8", + "isPartOf": "d9845", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1676,7 +1697,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bf514", - "isPartOf": "ffdc5", + "isPartOf": "cd204", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1738,7 +1759,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bfa48", - "isPartOf": "d9adf", + "isPartOf": "c6dc3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1783,7 +1804,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bfb2b", - "isPartOf": "c13f9", + "isPartOf": "efcb3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1834,7 +1855,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "bfd3c", - "isPartOf": "d1d1c", + "isPartOf": "df474", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1868,35 +1889,6 @@ "y": 88, "zIndex": 32768 }, - "c13f9": { - "contains": [ - "bfb2b", - "b2374" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "c13f9", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 96, - "x": 131, - "y": 656, - "zIndex": 32768 - }, "c1469": { "drawAs": "rect", "fill": "#ffffff", @@ -1907,7 +1899,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c1469", - "isPartOf": "d7d10", + "isPartOf": "f50fe", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1955,7 +1947,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "c4d98", - "isPartOf": "e39e1", + "isPartOf": "df7af", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -1991,34 +1983,39 @@ "y": 68, "zIndex": 32768 }, - "cac23": { + "c6dc3": { "contains": [ - "a0b8c", - "a13cc" + "e784a", + "a532d", + "b348f", + "bfa48", + "cfdfc", + "e7ee3", + "f91cd" ], - "drawAs": "Octagon", - "fill": "#b4b464", + "drawAs": "none", + "fill": "transparent", "fillOpacity": 0.1, "fontSize": 1, "fontWeight": "bold", "gpmlElementName": "Group", - "height": 64, - "id": "cac23", + "height": 156, + "id": "c6dc3", "kaavioType": "Group", - "padding": 11, + "padding": 8, "stroke": "#808080", - "strokeWidth": 1, + "strokeDasharray": "5,3", + "strokeWidth": 0, "textAlign": "center", "type": [ "Group", - "Complex", - "GroupComplex" + "GroupGroup" ], "verticalAlign": "middle", - "width": 104, - "x": 301.25, - "y": 220.75, - "zIndex": 32768 + "width": 194, + "x": 66, + "y": 117, + "zIndex": 28672 }, "cad96": { "comments": [ @@ -2095,7 +2092,8 @@ "HGNC:MGA", "UniProt:H3BU53", "UniProt:Q8IWI9", - "UniProt:H3BP52" + "UniProt:H3BP52", + "UniProt:A0A8C8P5L8" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2138,7 +2136,6 @@ "Entrez Gene:55914", "HGNC:ERBIN", "UniProt:B4DIP2", - "UniProt:H0Y9E8", "UniProt:Q96RT1", "UniProt:H0YA04" ], @@ -2162,7 +2159,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "cbf74", - "isPartOf": "ffdc5", + "isPartOf": "cd204", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2201,6 +2198,35 @@ "y": 8, "zIndex": 32768 }, + "cd204": { + "contains": [ + "bf514", + "cbf74" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "cd204", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 96, + "x": 930, + "y": 687, + "zIndex": 32768 + }, "ce9f0": { "drawAs": "rect", "fill": "#ffffff", @@ -2211,7 +2237,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "ce9f0", - "isPartOf": "e5865", + "isPartOf": "a6ae1", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2326,7 +2352,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "cfdfc", - "isPartOf": "d9adf", + "isPartOf": "c6dc3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2545,38 +2571,6 @@ "y": 605, "zIndex": 32768 }, - "d1d1c": { - "contains": [ - "a829a", - "d9822", - "e66f2", - "f9375", - "bfd3c" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 116, - "id": "d1d1c", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 199, - "x": 469, - "y": 299, - "zIndex": 28672 - }, "d2aa0": { "drawAs": "rect", "fill": "#ffffff", @@ -2679,7 +2673,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "d37dd", - "isPartOf": "e5865", + "isPartOf": "a6ae1", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2799,38 +2793,6 @@ "y": 801, "zIndex": 32771 }, - "d7d10": { - "contains": [ - "e2b0b", - "eb6d1", - "e1771", - "e24ef", - "c1469" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 116, - "id": "d7d10", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 204, - "x": 470, - "y": 110, - "zIndex": 28672 - }, "d9822": { "drawAs": "rect", "fill": "#ffffff", @@ -2841,7 +2803,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "d9822", - "isPartOf": "d1d1c", + "isPartOf": "df474", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -2875,39 +2837,34 @@ "y": 48, "zIndex": 32768 }, - "d9adf": { + "d9845": { "contains": [ - "e784a", - "f91cd", - "b348f", - "cfdfc", - "a532d", - "bfa48", - "e7ee3" + "bdfdd", + "eefd7" ], - "drawAs": "none", - "fill": "transparent", + "drawAs": "Octagon", + "fill": "#b4b464", "fillOpacity": 0.1, "fontSize": 1, "fontWeight": "bold", "gpmlElementName": "Group", - "height": 156, - "id": "d9adf", + "height": 64, + "id": "d9845", "kaavioType": "Group", - "padding": 8, + "padding": 11, "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, + "strokeWidth": 1, "textAlign": "center", "type": [ "Group", - "GroupGroup" + "Complex", + "GroupComplex" ], "verticalAlign": "middle", - "width": 194, - "x": 66, - "y": 117, - "zIndex": 28672 + "width": 104, + "x": 1034, + "y": 540, + "zIndex": 32768 }, "d9e38": { "drawAs": "rect", @@ -2993,7 +2950,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "ddb3a", - "isPartOf": "b4c86", + "isPartOf": "abf8d", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3050,6 +3007,69 @@ "y": 28, "zIndex": 32768 }, + "df474": { + "contains": [ + "a829a", + "bfd3c", + "d9822", + "e66f2", + "f9375" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 116, + "id": "df474", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 199, + "x": 469, + "y": 299, + "zIndex": 28672 + }, + "df7af": { + "contains": [ + "faa39", + "b0e90", + "c4d98", + "e9485" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 96, + "id": "df7af", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 192, + "x": 42, + "y": 335, + "zIndex": 28672 + }, "e082c": { "comments": [ { @@ -3201,7 +3221,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e1771", - "isPartOf": "d7d10", + "isPartOf": "f50fe", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3250,7 +3270,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e24ef", - "isPartOf": "d7d10", + "isPartOf": "f50fe", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3271,13 +3291,45 @@ "Ensembl:ENSG00000055609", "Entrez Gene:58508", "HGNC:KMT2C", + "UniProt:A0A804HJV8", "UniProt:Q8NEZ4", - "UniProt:C9J4Z5", + "UniProt:A0A7P0T9N3", + "UniProt:A0A804HJT1", + "UniProt:A0A804HJ77", "UniProt:H7C212", + "UniProt:H7C2V8", + "UniProt:A0A804HIF3", + "UniProt:A0A804HJR9", + "UniProt:A0A7P0T8F0", + "UniProt:A0A804HKJ1", + "UniProt:A0A7P0TAI3", + "UniProt:A0A7P0TBM6", + "UniProt:A0A7P0TAQ8", + "UniProt:A0A804HLA5", + "UniProt:H7BY37", + "UniProt:A0A7P0T9U9", + "UniProt:A0A804HKS3", + "UniProt:A0A7P0T9Q7", + "UniProt:A0A804HIM1", + "UniProt:A0A804HKQ3", + "UniProt:A0A7P0TA60", + "UniProt:A0A804HIW6", + "UniProt:A0A804HKW4", + "UniProt:A0A804HIS4", + "UniProt:A0A804HJU5", + "UniProt:C9J4Z5", + "UniProt:A0A804HIG3", + "UniProt:A0A7P0T9K8", + "UniProt:A0A804HJ27", + "UniProt:A0A804HK48", + "UniProt:A0A804HI08", + "UniProt:A0A804HIK3", + "UniProt:A0A804HIM6", + "UniProt:A0A804HLD4", + "UniProt:A0A7P0Z448", "UniProt:H0Y765", "UniProt:H0YNL4", - "UniProt:H7C2V8", - "UniProt:H7BY37" + "UniProt:A0A804HHW0" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3299,7 +3351,7 @@ "gpmlElementName": "Label", "height": 20, "id": "e2b0b", - "isPartOf": "d7d10", + "isPartOf": "f50fe", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3321,37 +3373,6 @@ "y": 8, "zIndex": 28672 }, - "e39e1": { - "contains": [ - "faa39", - "b0e90", - "e9485", - "c4d98" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 96, - "id": "e39e1", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 192, - "x": 42, - "y": 335, - "zIndex": 28672 - }, "e4f9f": { "drawAs": "none", "fill": "transparent", @@ -3383,68 +3404,6 @@ "y": 1110, "zIndex": 28672 }, - "e55b8": { - "contains": [ - "bdfdd", - "eefd7" - ], - "drawAs": "Octagon", - "fill": "#b4b464", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 64, - "id": "e55b8", - "kaavioType": "Group", - "padding": 11, - "stroke": "#808080", - "strokeWidth": 1, - "textAlign": "center", - "type": [ - "Group", - "Complex", - "GroupComplex" - ], - "verticalAlign": "middle", - "width": 104, - "x": 1034, - "y": 540, - "zIndex": 32768 - }, - "e5865": { - "contains": [ - "ff487", - "ce9f0", - "a73fe", - "d37dd", - "fb2c2", - "f2b49" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 136, - "id": "e5865", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 193, - "x": 257, - "y": 23, - "zIndex": 28672 - }, "e66f2": { "drawAs": "rect", "fill": "#ffffff", @@ -3455,7 +3414,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e66f2", - "isPartOf": "d1d1c", + "isPartOf": "df474", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3483,14 +3442,17 @@ "UniProt:A0A6Q8PFD0", "UniProt:F5H6S1", "UniProt:F5H5V6", + "UniProt:A0A804HLJ3", "UniProt:A0A6Q8PGG6", "UniProt:A0A6Q8PHB6", "UniProt:H0Y6I7", "UniProt:A0A087WUN6", + "UniProt:A0A804HJA2", "UniProt:A0A6Q8PG92", "UniProt:A0A6Q8PH94", "UniProt:A0A6Q8PGN0", "UniProt:A0A6Q8PG32", + "UniProt:A0A804HIZ7", "UniProt:A0A6Q8PFK0", "UniProt:H0Y6V5" ], @@ -3585,6 +3547,7 @@ "UniProt:G3V3X1", "UniProt:P31749", "UniProt:G3V2I6", + "UniProt:A0A804HJM6", "UniProt:B0LPE5", "UniProt:A0A087WY56" ], @@ -3677,7 +3640,7 @@ "gpmlElementName": "Label", "height": 20, "id": "e784a", - "isPartOf": "d9adf", + "isPartOf": "c6dc3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3709,7 +3672,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e7ee3", - "isPartOf": "d9adf", + "isPartOf": "c6dc3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3762,7 +3725,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "e9485", - "isPartOf": "e39e1", + "isPartOf": "df7af", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -3832,7 +3795,8 @@ "Ensembl:ENSG00000118689", "Entrez Gene:2309", "HGNC:FOXO3", - "UniProt:O43524" + "UniProt:O43524", + "UniProt:A0A856PRE8" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3874,7 +3838,8 @@ "Ensembl:ENSG00000196468", "Entrez Gene:8823", "HGNC:FGF16", - "UniProt:O43320" + "UniProt:O43320", + "UniProt:A0A7U3L5H2" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3947,7 +3912,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "eb6d1", - "isPartOf": "d7d10", + "isPartOf": "f50fe", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4063,7 +4028,6 @@ "UniProt:E9PGB1", "UniProt:H0Y913", "UniProt:X5D8Y5", - "UniProt:E7EPF8", "UniProt:E7ESU7", "UniProt:Q13363", "UniProt:E7EUB3", @@ -4111,7 +4075,15 @@ "Ensembl:ENSG00000148400", "Entrez Gene:4851", "HGNC:NOTCH1", - "UniProt:P46531" + "UniProt:A0A7P0TAK8", + "UniProt:A0A7P0TBG2", + "UniProt:A0A7P0T8U6", + "UniProt:A0A7P0T9V1", + "UniProt:A0A7P0TA56", + "UniProt:P46531", + "UniProt:A0A7P0TB20", + "UniProt:A0A7P0T8W1", + "UniProt:A0A7P0Z4H9" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4133,7 +4105,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "eefd7", - "isPartOf": "e55b8", + "isPartOf": "d9845", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4166,6 +4138,35 @@ "y": 32, "zIndex": 32768 }, + "efcb3": { + "contains": [ + "b2374", + "bfb2b" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 56, + "id": "efcb3", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 96, + "x": 131, + "y": 656, + "zIndex": 32768 + }, "f1e71": { "drawAs": "rect", "fill": "#ffffff", @@ -4209,6 +4210,35 @@ "y": 752, "zIndex": 32768 }, + "f29c2": { + "contains": [ + "a0b8c", + "a13cc" + ], + "drawAs": "Octagon", + "fill": "#b4b464", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 64, + "id": "f29c2", + "kaavioType": "Group", + "padding": 11, + "stroke": "#808080", + "strokeWidth": 1, + "textAlign": "center", + "type": [ + "Group", + "Complex", + "GroupComplex" + ], + "verticalAlign": "middle", + "width": 104, + "x": 301.25, + "y": 220.75, + "zIndex": 32768 + }, "f2b49": { "drawAs": "rect", "fill": "#ffffff", @@ -4219,7 +4249,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f2b49", - "isPartOf": "e5865", + "isPartOf": "a6ae1", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4241,7 +4271,6 @@ "Entrez Gene:10847", "HGNC:SRCAP", "UniProt:A0A087X0E3", - "UniProt:A0A0A0MS59", "UniProt:C9J4U4", "UniProt:Q6ZRS2" ], @@ -4255,6 +4284,38 @@ "y": 108, "zIndex": 32768 }, + "f50fe": { + "contains": [ + "e2b0b", + "c1469", + "e1771", + "e24ef", + "eb6d1" + ], + "drawAs": "none", + "fill": "transparent", + "fillOpacity": 0.1, + "fontSize": 1, + "fontWeight": "bold", + "gpmlElementName": "Group", + "height": 116, + "id": "f50fe", + "kaavioType": "Group", + "padding": 8, + "stroke": "#808080", + "strokeDasharray": "5,3", + "strokeWidth": 0, + "textAlign": "center", + "type": [ + "Group", + "GroupGroup" + ], + "verticalAlign": "middle", + "width": 204, + "x": 470, + "y": 110, + "zIndex": 28672 + }, "f598d": { "attachmentDisplay": { "offset": [ @@ -4329,7 +4390,6 @@ "UniProt:E9PH68", "UniProt:A0A024R1V0", "UniProt:H0Y8B8", - "UniProt:H0Y881", "UniProt:A0A024R1Z8", "UniProt:H0Y8D8", "UniProt:A0A2R8Y6Y9", @@ -4396,7 +4456,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f91cd", - "isPartOf": "d9adf", + "isPartOf": "c6dc3", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4444,7 +4504,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "f9375", - "isPartOf": "d1d1c", + "isPartOf": "df474", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4465,6 +4525,7 @@ "Ensembl:ENSG00000150347", "Entrez Gene:84159", "HGNC:ARID5B", + "UniProt:A0A7P0TAD2", "UniProt:Q14865", "UniProt:A0A2R8Y5F2" ], @@ -4547,7 +4608,7 @@ "gpmlElementName": "Label", "height": 20, "id": "faa39", - "isPartOf": "e39e1", + "isPartOf": "df7af", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4579,7 +4640,7 @@ "gpmlElementName": "DataNode", "height": 20, "id": "fb2c2", - "isPartOf": "e5865", + "isPartOf": "a6ae1", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4788,7 +4849,7 @@ "gpmlElementName": "Label", "height": 20, "id": "ff487", - "isPartOf": "e5865", + "isPartOf": "a6ae1", "kaavioType": "SingleFreeNode", "lineHeight": 1.1, "overflow": "hidden", @@ -4810,35 +4871,6 @@ "y": 8, "zIndex": 28672 }, - "ffdc5": { - "contains": [ - "cbf74", - "bf514" - ], - "drawAs": "none", - "fill": "transparent", - "fillOpacity": 0.1, - "fontSize": 1, - "fontWeight": "bold", - "gpmlElementName": "Group", - "height": 56, - "id": "ffdc5", - "kaavioType": "Group", - "padding": 8, - "stroke": "#808080", - "strokeDasharray": "5,3", - "strokeWidth": 0, - "textAlign": "center", - "type": [ - "Group", - "GroupGroup" - ], - "verticalAlign": "middle", - "width": 96, - "x": 930, - "y": 687, - "zIndex": 32768 - }, "ffde8": { "drawAs": "rect", "fill": "#ffffff", @@ -4886,6 +4918,16 @@ "y": 163, "zIndex": 32768 }, + "http://identifiers.org/doid/DOID:4877": { + "gpmlElementName": "openControlledVocabulary", + "id": "http://identifiers.org/doid/DOID:4877", + "ontology": "Disease", + "term": "breast adenoid cystic carcinoma", + "type": [ + "openControlledVocabulary" + ], + "xrefIdentifier": "DOID:4877" + }, "http://identifiers.org/pw/PW:0000089": { "gpmlElementName": "openControlledVocabulary", "id": "http://identifiers.org/pw/PW:0000089", @@ -4939,7 +4981,6 @@ 0.5 ] }, - "id": "f2383", "isAttachedTo": "e0944", "orientation": [ 1, @@ -4959,7 +5000,6 @@ 0.5 ] }, - "id": "bb2f0", "isAttachedTo": "d2aa0", "orientation": [ 1, @@ -5000,7 +5040,6 @@ 0.5 ] }, - "id": "e8662", "isAttachedTo": "ffde8", "orientation": [ -1, @@ -5020,7 +5059,6 @@ 0.5 ] }, - "id": "d0292", "isAttachedTo": "bc3b3", "orientation": [ -1, @@ -5065,7 +5103,6 @@ 0.5 ] }, - "id": "c001d", "isAttachedTo": "ed289", "orientation": [ 1, @@ -5086,7 +5123,6 @@ 0 ] }, - "id": "c4b01", "isAttachedTo": "f598d", "orientation": [], "x": 364, @@ -5124,7 +5160,6 @@ 1 ] }, - "id": "f48d1", "isAttachedTo": "ea82c", "orientation": [ 0, @@ -5144,7 +5179,6 @@ 0 ] }, - "id": "d2a5a", "isAttachedTo": "e6f35", "orientation": [ 0, @@ -5189,7 +5223,6 @@ 1 ] }, - "id": "ce90e", "isAttachedTo": "f1e71", "orientation": [ 0, @@ -5209,7 +5242,6 @@ 0 ] }, - "id": "b24a8", "isAttachedTo": "d09c0", "orientation": [ 0, @@ -5254,7 +5286,6 @@ 1 ] }, - "id": "b806f", "isAttachedTo": "e6f95", "orientation": [ 0, @@ -5274,7 +5305,6 @@ 0 ] }, - "id": "e04aa", "isAttachedTo": "e94f3", "orientation": [ 0, @@ -5315,7 +5345,6 @@ 1 ] }, - "id": "b579c", "isAttachedTo": "b43e7", "orientation": [ 0, @@ -5335,7 +5364,6 @@ 0 ] }, - "id": "e7256", "isAttachedTo": "b683e", "orientation": [ 0, @@ -5364,7 +5392,7 @@ "id": "id27ccef16", "isAttachedTo": [ "fa0ca", - "c13f9" + "efcb3" ], "kaavioType": "Edge", "markerEnd": "Arrow", @@ -5380,7 +5408,6 @@ 1 ] }, - "id": "ca68d", "isAttachedTo": "fa0ca", "orientation": [ 0, @@ -5400,8 +5427,7 @@ 0 ] }, - "id": "dd512", - "isAttachedTo": "c13f9", + "isAttachedTo": "efcb3", "orientation": [ 0, 1 @@ -5428,8 +5454,8 @@ "gpmlElementName": "Interaction", "id": "id29c11519", "isAttachedTo": [ - "d1d1c", - "cac23" + "df474", + "f29c2" ], "kaavioType": "Edge", "markerEnd": "Arrow", @@ -5445,8 +5471,7 @@ 0.5 ] }, - "id": "c611e", - "isAttachedTo": "d1d1c", + "isAttachedTo": "df474", "orientation": [ -1, 0 @@ -5465,8 +5490,7 @@ 0.75 ] }, - "id": "cacd6", - "isAttachedTo": "cac23", + "isAttachedTo": "f29c2", "orientation": [ -1, 0 @@ -5511,7 +5535,6 @@ 1 ] }, - "id": "e5f1c", "isAttachedTo": "b531a", "orientation": [ 0, @@ -5531,7 +5554,6 @@ 0 ] }, - "id": "fd765", "isAttachedTo": "ab98c", "orientation": [ 0, @@ -5576,7 +5598,6 @@ 0 ] }, - "id": "c54cb", "isAttachedTo": "b82b2", "orientation": [ 0, @@ -5596,7 +5617,6 @@ 1 ] }, - "id": "b67e4", "isAttachedTo": "d0249", "orientation": [ 0, @@ -5637,7 +5657,6 @@ 1 ] }, - "id": "a64b6", "isAttachedTo": "d9e38", "orientation": [ 0, @@ -5657,7 +5676,6 @@ 0 ] }, - "id": "fafb2", "isAttachedTo": "e4f9f", "orientation": [ 0, @@ -5702,7 +5720,6 @@ 1 ] }, - "id": "dc7d5", "isAttachedTo": "fcee7", "orientation": [ 0, @@ -5722,7 +5739,6 @@ 0 ] }, - "id": "a1d8b", "isAttachedTo": "bdfdd", "orientation": [ 0, @@ -5763,7 +5779,6 @@ 1 ] }, - "id": "b6183", "isAttachedTo": "e082c", "orientation": [ 0, @@ -5783,7 +5798,6 @@ 0 ] }, - "id": "c3e48", "isAttachedTo": "f1e71", "orientation": [ 0, @@ -5828,7 +5842,6 @@ 1 ] }, - "id": "fbeb4", "isAttachedTo": "b32b8", "orientation": [ 0, @@ -5848,7 +5861,6 @@ 0 ] }, - "id": "a2b77", "isAttachedTo": "d9e38", "orientation": [ 0, @@ -5893,7 +5905,6 @@ 1 ] }, - "id": "eee99", "isAttachedTo": "ab98c", "orientation": [ 0, @@ -5913,7 +5924,6 @@ 0 ] }, - "id": "e17e4", "isAttachedTo": "b1889", "orientation": [ 0, @@ -5958,7 +5968,6 @@ 1 ] }, - "id": "cbbdd", "isAttachedTo": "e94f3", "orientation": [ 0, @@ -5978,7 +5987,6 @@ 0 ] }, - "id": "f1739", "isAttachedTo": "d7810", "orientation": [ 0, @@ -6023,7 +6031,6 @@ 0.5 ] }, - "id": "fcf21", "isAttachedTo": "cae38", "orientation": [ 1, @@ -6043,7 +6050,6 @@ 0.5 ] }, - "id": "e0e9c", "isAttachedTo": "ea82c", "orientation": [ 1, @@ -6084,7 +6090,6 @@ 1 ] }, - "id": "d64fe", "isAttachedTo": "abcf7", "orientation": [ 0, @@ -6104,7 +6109,6 @@ 0 ] }, - "id": "ac815", "isAttachedTo": "ee1da", "orientation": [ 0, @@ -6149,7 +6153,6 @@ 1 ] }, - "id": "b3ebb", "isAttachedTo": "cbb1f", "orientation": [ 0, @@ -6169,7 +6172,6 @@ 0 ] }, - "id": "ed870", "isAttachedTo": "b43e7", "orientation": [ 0, @@ -6214,7 +6216,6 @@ 0.5 ] }, - "id": "c2260", "isAttachedTo": "b45b2", "orientation": [ -1, @@ -6235,7 +6236,6 @@ 0 ] }, - "id": "d8955", "isAttachedTo": "f598d", "orientation": [], "x": 364, @@ -6273,7 +6273,6 @@ 1 ] }, - "id": "d8299", "isAttachedTo": "b32b8", "orientation": [ 0, @@ -6293,7 +6292,6 @@ 0 ] }, - "id": "ac451", "isAttachedTo": "ba7f7", "orientation": [ 0, @@ -6338,7 +6336,6 @@ 0.5 ] }, - "id": "e3ff6", "isAttachedTo": "a2413", "orientation": [ 1, @@ -6358,7 +6355,6 @@ 0.5 ] }, - "id": "bd0b0", "isAttachedTo": "fc88b", "orientation": [ 1, @@ -6403,7 +6399,6 @@ 1 ] }, - "id": "fc13b", "isAttachedTo": "b1889", "orientation": [ 0, @@ -6423,7 +6418,6 @@ 0 ] }, - "id": "de0fd", "isAttachedTo": "f8d8f", "orientation": [ 0, @@ -6464,7 +6458,6 @@ 0.5 ] }, - "id": "f9ab9", "isAttachedTo": "d36d2", "orientation": [ -1, @@ -6484,7 +6477,6 @@ 0.5 ] }, - "id": "e771d", "isAttachedTo": "b1889", "orientation": [ -1, @@ -6525,7 +6517,6 @@ 1 ] }, - "id": "ff1ec", "isAttachedTo": "ab98c", "orientation": [ 0, @@ -6545,7 +6536,6 @@ 0 ] }, - "id": "ce3e0", "isAttachedTo": "cfef6", "orientation": [ 0, @@ -6590,7 +6580,6 @@ 0.5 ] }, - "id": "b403d", "isAttachedTo": "d16a2", "orientation": [ 1, @@ -6610,7 +6599,6 @@ 0.5 ] }, - "id": "c2353", "isAttachedTo": "fa0ca", "orientation": [ 1, @@ -6638,8 +6626,8 @@ "gpmlElementName": "Interaction", "id": "id7efacd0c", "isAttachedTo": [ - "e5865", - "cac23" + "a6ae1", + "f29c2" ], "kaavioType": "Edge", "markerEnd": "Arrow", @@ -6655,8 +6643,7 @@ 1 ] }, - "id": "e2833", - "isAttachedTo": "e5865", + "isAttachedTo": "a6ae1", "orientation": [ 0, 1 @@ -6675,8 +6662,7 @@ 0 ] }, - "id": "f3aa6", - "isAttachedTo": "cac23", + "isAttachedTo": "f29c2", "orientation": [ 0, 1 @@ -6704,7 +6690,7 @@ "gpmlElementName": "Interaction", "id": "id7fd16d", "isAttachedTo": [ - "cac23", + "f29c2", "fca2d" ], "kaavioType": "Edge", @@ -6721,8 +6707,7 @@ 1 ] }, - "id": "cea42", - "isAttachedTo": "cac23", + "isAttachedTo": "f29c2", "orientation": [ 0, 1 @@ -6741,7 +6726,6 @@ 0 ] }, - "id": "c6a89", "isAttachedTo": "fca2d", "orientation": [ 0, @@ -6786,7 +6770,6 @@ 1 ] }, - "id": "e4e4e", "isAttachedTo": "f647c", "orientation": [ 0, @@ -6806,7 +6789,6 @@ 0 ] }, - "id": "adde7", "isAttachedTo": "b20c8", "orientation": [ 0, @@ -6851,7 +6833,6 @@ 0.5 ] }, - "id": "e17b5", "isAttachedTo": "aa6fc", "orientation": [ -1, @@ -6872,7 +6853,6 @@ 0 ] }, - "id": "bdfd0", "isAttachedTo": "f598d", "orientation": [], "x": 364, @@ -6910,7 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"isAttachedTo": "c6dc3", "orientation": [ 1, 0 @@ -7190,8 +7161,7 @@ 0.25 ] }, - "id": "dbca6", - "isAttachedTo": "cac23", + "isAttachedTo": "f29c2", "orientation": [ 1, 0 @@ -7219,8 +7189,8 @@ "gpmlElementName": "Interaction", "id": "ida0f810d6", "isAttachedTo": [ - "d7d10", - "cac23" + "f50fe", + "f29c2" ], "kaavioType": "Edge", "markerEnd": "Arrow", @@ -7236,8 +7206,7 @@ 0.75 ] }, - "id": "ba3c8", - "isAttachedTo": "d7d10", + "isAttachedTo": "f50fe", "orientation": [ -1, 0 @@ -7256,8 +7225,7 @@ 0.25 ] }, - "id": "c009a", - "isAttachedTo": "cac23", + "isAttachedTo": "f29c2", "orientation": [ -1, 0 @@ -7302,7 +7270,6 @@ 1 ] }, - "id": "a406a", "isAttachedTo": "b683e", "orientation": [ 0, @@ -7322,7 +7289,6 @@ 0 ] }, - "id": "d039a", "isAttachedTo": "e082c", "orientation": [ 0, @@ -7350,7 +7316,7 @@ "gpmlElementName": "Interaction", "id": "idb243fcd2", "isAttachedTo": [ - "ffdc5", + "cd204", "e0944" ], "kaavioType": "Edge", @@ -7367,8 +7333,7 @@ 0 ] }, - "id": "d6c11", - "isAttachedTo": "ffdc5", + "isAttachedTo": "cd204", "orientation": [ 0, -1 @@ -7387,7 +7352,6 @@ 1 ] }, - "id": "ca5f9", "isAttachedTo": "e0944", "orientation": [ 0, @@ -7415,8 +7379,8 @@ "gpmlElementName": "Interaction", "id": "idb4122b2e", "isAttachedTo": [ - "e39e1", - "cac23" + "df7af", + "f29c2" ], "kaavioType": "Edge", "markerEnd": "Arrow", @@ -7432,8 +7396,7 @@ 0.25 ] }, - "id": "ba512", - "isAttachedTo": "e39e1", + "isAttachedTo": "df7af", "orientation": [ 1, 0 @@ -7452,8 +7415,7 @@ 0.75 ] }, - "id": "d4782", - "isAttachedTo": "cac23", + "isAttachedTo": "f29c2", "orientation": [ 1, 0 @@ -7481,7 +7443,7 @@ "gpmlElementName": "Interaction", "id": "idb9ee254a", "isAttachedTo": [ - "b4c86", + "abf8d", "a91b5" ], "kaavioType": "Edge", @@ -7498,8 +7460,7 @@ 0.5 ] }, - "id": "e8206", - "isAttachedTo": "b4c86", + "isAttachedTo": "abf8d", "orientation": [ 1, 0 @@ -7518,7 +7479,6 @@ 0.5 ] }, - "id": "df8bc", "isAttachedTo": "a91b5", "orientation": [ 1, @@ -7559,7 +7519,6 @@ 1 ] }, - 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@@ 0.5 ] }, - "id": "a58b4", "isAttachedTo": "a7f60", "orientation": [ 1, @@ -7884,7 +7834,6 @@ 0.5 ] }, - "id": "e18bf", "isAttachedTo": "ab98c", "orientation": [ -1, @@ -7904,7 +7853,6 @@ 0.5 ] }, - "id": "f8c0f", "isAttachedTo": "ffde8", "orientation": [ -1, @@ -7945,7 +7893,6 @@ 1 ] }, - "id": "fac45", "isAttachedTo": "b531a", "orientation": [ 0, @@ -7965,7 +7912,6 @@ 0 ] }, - "id": "d90a3", "isAttachedTo": "a2413", "orientation": [ 0, @@ -8013,7 +7959,6 @@ 1 ] }, - "id": "c94e6", "isAttachedTo": "ee1da", "orientation": [ 0, @@ -8033,7 +7978,6 @@ 0 ] }, - "id": "dc900", "isAttachedTo": "b32b8", "orientation": [ 0, @@ -8061,7 +8005,7 @@ "gpmlElementName": "Interaction", "id": "idd57a9301", "isAttachedTo": [ - "e55b8", + "d9845", "d2aa0" ], "kaavioType": "Edge", @@ -8078,8 +8022,7 @@ 1 ] }, - "id": "f5c8b", - "isAttachedTo": "e55b8", + "isAttachedTo": "d9845", "orientation": [ 0, 1 @@ -8098,7 +8041,6 @@ 0 ] }, - "id": "bda6e", "isAttachedTo": "d2aa0", "orientation": [ 0, @@ -8126,7 +8068,7 @@ "gpmlElementName": "Interaction", "id": "iddf36396c", "isAttachedTo": [ - "b4c86", + "abf8d", "fa0ca" ], "kaavioType": "Edge", @@ -8143,8 +8085,7 @@ 1 ] }, - "id": "efeb0", - "isAttachedTo": "b4c86", + "isAttachedTo": "abf8d", "orientation": [ 0, 1 @@ -8163,7 +8104,6 @@ 0 ] }, - "id": "dabce", "isAttachedTo": "fa0ca", "orientation": [ 0, @@ -8208,7 +8148,6 @@ 0.5 ] }, - "id": "b4f3b", "isAttachedTo": "cfef6", "orientation": [ -1, @@ -8228,7 +8167,6 @@ 0.5 ] }, - "id": "c20bb", "isAttachedTo": "cad96", "orientation": [ -1, @@ -8273,7 +8211,6 @@ 1 ] }, - "id": "fad15", "isAttachedTo": "b20c8", "orientation": [ 0, @@ -8293,7 +8230,6 @@ 0 ] }, - "id": "dfbde", "isAttachedTo": "e16e5", "orientation": [ 0, @@ -8334,7 +8270,6 @@ 0.5 ] }, - "id": "be7a1", "isAttachedTo": "ab98c", "orientation": [ 1, @@ -8354,7 +8289,6 @@ 0 ] }, - "id": "fac58", "isAttachedTo": "b9b6b", "orientation": [ 0, @@ -8383,7 +8317,7 @@ "id": "idea859870", "isAttachedTo": [ "e99d3", - "e55b8" + "d9845" ], "kaavioType": "Edge", "markerEnd": "Arrow", @@ -8399,7 +8333,6 @@ 1 ] }, - "id": "d9fde", "isAttachedTo": "e99d3", "orientation": [ 0, @@ -8419,8 +8352,7 @@ 0 ] }, - "id": "d7c37", - "isAttachedTo": "e55b8", + "isAttachedTo": "d9845", "orientation": [ 0, 1 @@ -8464,7 +8396,6 @@ 0 ] }, - "id": "c6aef", "isAttachedTo": "b1889", "orientation": [ 0, @@ -8484,7 +8415,6 @@ 1 ] }, - "id": "f4e06", "isAttachedTo": "b9b6b", "orientation": [ 0, @@ -8513,7 +8443,7 @@ "id": "idf0b93036", "isAttachedTo": [ "b14b1", - "c13f9" + "efcb3" ], "kaavioType": "Edge", "markerEnd": "Arrow", @@ -8529,7 +8459,6 @@ 0.5 ] }, - "id": "b8872", "isAttachedTo": "b14b1", "orientation": [ 1, @@ -8549,8 +8478,7 @@ 0.5 ] }, - "id": "e5a04", - "isAttachedTo": "c13f9", + "isAttachedTo": "efcb3", "orientation": [ 1, 0 @@ -8594,7 +8522,6 @@ 1 ] }, - "id": "d7ef9", "isAttachedTo": "e16e5", "orientation": [ 0, @@ -8614,7 +8541,6 @@ 0 ] }, - "id": "c4747", "isAttachedTo": "b3784", "orientation": [ 0, @@ -8659,7 +8585,6 @@ 1 ] }, - "id": "b00c4", "isAttachedTo": "d2aa0", "orientation": [ 0, @@ -8679,7 +8604,6 @@ 0 ] }, - "id": "a2e5e", "isAttachedTo": "e6f95", "orientation": [ 0, @@ -8724,7 +8648,6 @@ 1 ] }, - "id": "be028", "isAttachedTo": "ab98c", "orientation": [ 0, @@ -8744,7 +8667,6 @@ 0 ] }, - "id": "ba7b7", "isAttachedTo": "f647c", "orientation": [ 0, @@ -8789,7 +8711,6 @@ 0.5 ] }, - "id": "e9e7e", "isAttachedTo": "fa0ca", "orientation": [ 1, @@ -8809,7 +8730,6 @@ 0.5 ] }, - "id": "ed71c", "isAttachedTo": "d0249", "orientation": [ 1, @@ -8890,7 +8810,7 @@ "@context": [ "https://cdn.rawgit.com/wikipathways/WpVocabularies/7a46a05/contexts/pvjs.jsonld", { - "@base": "http://identifiers.org/wikipathways/WP3651/" + "@base": "WP3651/" } ], "author": "[AAR&Co, Khanspers, Eweitz, Egonw]", @@ -8901,141 +8821,141 @@ } ], "contains": [ - "idccb6c0c4", - "id71198e04", - "id6d3192e3", - "ide2af8342", - "id69d437e8", - "idbd289167", - "id14479078", - "iddfde4367", - "id930cc9ce", - "id35d8d9c7", - "id55017ec0", - "id3f3af077", "id1318e08f", - "id1efade1f", - "id51b71e7f", + "id14479078", + "id19fb1585", "id1b07a648", - "idce94a352", + "id1efade1f", + "id1f0ec620", "id2db05937", - "ide49dab7b", - "id910cf44b", + "id35d8d9c7", + "id382cdc5c", + "id3f3af077", + "id407876d", + "id42d06968", "id47b8cf30", - "idef33e422", - "idf7930db2", + "id51b71e7f", + "id55017ec0", + "id55568f45", + "id5e196aab", + "id67ee2300", + "id69d437e8", + "id6d3192e3", + "id71198e04", "id7a7538e4", + "id7b1f86fa", "id859dea07", + "id910cf44b", "id913442af", - "idf52c67a8", - "id7b1f86fa", - "idfc2e3cbf", - "idc593a148", - "id19fb1585", - "id5e196aab", - "id1f0ec620", + "id930cc9ce", + "id9bec5a18", "ida66ab56f", - "id407876d", - "idf5c8300b", + "idbc435f30", + "idbd289167", "idc3429b81", - "id9bec5a18", + "idc593a148", + "idccb6c0c4", + "idce94a352", "idd34ea317", - "id880f790d", "id1505063e", - "id42d06968", - "id67ee2300", - "id382cdc5c", - "idbc435f30", - "id55568f45", "id65e7d692", - "id7fd16d", - "idea859870", - "idd57a9301", - "id7efacd0c", - "ida0f810d6", - "id29c11519", - "idb4122b2e", - "id9cd04372", + "id880f790d", + "iddfde4367", + "ide2af8342", + "ide49dab7b", + "idef33e422", + "idf52c67a8", + "idf5c8300b", + "idf7930db2", + "idfc2e3cbf", "idb9ee254a", "iddf36396c", + "idb243fcd2", + "idd57a9301", + "idea859870", "id27ccef16", - "idf0b93036", "idbe70fc1d", - "idb243fcd2", + "idf0b93036", + "id29c11519", + "id7efacd0c", + "id7fd16d", + "id9cd04372", + "idb4122b2e", + "ida0f810d6", + "b53bf", "be4a2", "cf961", - "b53bf", "ec6f0", - "d397b", - "da124", + "aaab9", "b531a", - "fcc39", - "e709f", "b5dea", - "aaab9", + "d397b", + "da124", "e4f9f", - "e5865", - "d7d10", - "d1d1c", - "e39e1", - "d9adf", + "e709f", + "fcc39", + "a6ae1", + "c6dc3", + "df474", + "df7af", + "f50fe", "a2413", + "a7f60", + "a91b5", + "aa6fc", "ab98c", - "ffde8", - "cfef6", - "f647c", - "b9b6b", + "abcf7", + "b14b1", "b1889", - "d36d2", "b20c8", - "e16e5", - "f8d8f", - "a91b5", - "d16a2", - "b14b1", - "fa0ca", - "d0249", - "cae38", - "ea82c", + "b3784", + "b43e7", + "b45b2", + "b683e", "b82b2", - "fcee7", - "e99d3", + "b8b57", + "b9b6b", + "ba4ee", + "ba7f7", + "bc3b3", + "cad96", + "cae38", "cbb1f", + "cfef6", + "d0249", + "d09c0", + "d16a2", "d2aa0", - "b43e7", - "b683e", - "e0944", + "d36d2", + "d9e38", "e082c", + "e0944", + "e16e5", "e6f95", + "e72c9", "e94f3", - "f1e71", - "abcf7", - "ee1da", + "e99d3", + "ea82c", "ed289", - "b8b57", - "aa6fc", - "b45b2", - "d9e38", - "ba7f7", + "ee1da", + "f1e71", + "f647c", + "f8d8f", + "fa0ca", "fca2d", - "bc3b3", - "cad96", - "ba4ee", - "b3784", - "e72c9", - "a7f60", - "d09c0", - "cac23", - "e55b8", - "b4c86", - "c13f9", - "ffdc5", + "fcee7", + "ffde8", + "abf8d", + "cd204", + "d9845", + "efcb3", + "f29c2", "fc88b", "e6f35", "d7810", "b32b8" ], - "dataSourceVersion": "WP3651_r122573", + "dataSourceVersion": "WP3651_r134271", "displayName": "Pathways affected in adenoid cystic carcinoma", "drawAs": "rect", "fill": "white", @@ -9043,9 +8963,9 @@ "fontWeight": "bold", "gpmlElementName": "Pathway", "height": 1197, - "id": "http://identifiers.org/wikipathways/WP3651", + "id": "WP3651", "kaavioType": "Group", - "lastModified": "20220416105729", + "lastModified": "20240719064745", "name": "Pathways affected in adenoid cystic carcinoma", "organism": "Homo sapiens", "padding": 5, @@ -9054,7 +8974,7 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Pathways affected in adenoid cystic carcinoma\nLast Modified: 20220416105729\nOrganism: Homo sapiens", + "textContent": "Name: Pathways affected in adenoid cystic carcinoma\nLast Modified: 20240719064745\nOrganism: Homo sapiens", "type": [ "Pathway", "http://identifiers.org/pw/PW:0001360", diff --git a/pathways/WP3651/WP3651.png b/pathways/WP3651/WP3651.png index 761978c6a..4ca8288cb 100644 Binary files a/pathways/WP3651/WP3651.png and b/pathways/WP3651/WP3651.png differ diff --git a/pathways/WP3651/WP3651.svg b/pathways/WP3651/WP3651.svg index 614edea79..bc9e9d1cd 100644 --- a/pathways/WP3651/WP3651.svg +++ b/pathways/WP3651/WP3651.svg @@ -1,5 +1,5 @@ - + @@ -34,18 +34,18 @@ - - - - - - + + + + + + @@ -460,51 +460,41 @@ - - - - - - - - - - - - - - - + + + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + @@ -512,9 +502,9 @@ - - - + + + @@ -522,14 +512,19 @@ - - - + + + - - - + + + + + + + + @@ -537,44 +532,39 @@ - - - - - - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + @@ -582,49 +572,34 @@ - - - - - - - - - - - - - - - - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + @@ -632,14 +607,14 @@ - - - + + + - - - + + + @@ -647,9 +622,19 @@ - - - + + + + + + + + + + + + + @@ -660,84 +645,59 @@ - - - - - - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - - - - - - - - - - - - - - - - - - - - - + + + - - - + + + - - - + + + @@ -750,24 +710,69 @@ + + + + + + + + + + + + + + + + + + + + - - - + + + - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -780,26 +785,15 @@ - - - - - - - - - Epigenetic Modification - - - - - - DNA Damage/Checkpoint Signaling + + + + Notch Signal @@ -808,28 +802,22 @@ DNA Damage - - - - MYB/MYC Signaling - - - - - - MYB Depression - - FGF/IGF/PI3K Signaling - - - - Notch Signal + + + + Epigenetic Modification + + + + + + DNA Damage/Checkpoint Signaling @@ -838,113 +826,137 @@ Pathway Activation - - + + + + MYB Depression + + + + + + MYB/MYC Signaling + + + + SWI/SNF Complex Activity - - - - SMARCA2 - - SMARCE1 + + + + SMARCA2 + + ATRX + + + + SRCAP + + ARID1A - - - - SRCAP - - - - - - - - Histone Methyltransferase Activity + + + + + + Histone Acetyltransferase Activity - - - - SETD2 + + + + BRD1 - - - - NSD1 + + + + MORF4L1 - - - - KMT2C + + + + EP300 - - - - CMTR2 + + + + KAT6A + + + + + + KANSL1 + + + + + + CREBBP - - + + Histone Demethylase Activity + + + + JMJD1C + + KDM6B - + KDM6A - + ARID5B - - - - JMJD1C - - - - + + @@ -957,61 +969,49 @@ ARID4B - - - - BCOR - - BCORL1 + + + + BCOR + + - - - - - - Histone Acetyltransferase Activity + + + + + + Histone Methyltransferase Activity - - - - CREBBP - - - - - - MORF4L1 - - - - - - KAT6A + + + + CMTR2 - - - - BRD1 + + + + NSD1 - - - - EP300 + + + + KMT2C - - - - KANSL1 + + + + SETD2 @@ -1021,34 +1021,40 @@ PRKDC - - - - ATM + + + + Growth/Proliferation + + + + + + NFIB - - - - CREBBP + + + + DTX4 - - - - SMC1A + + + + ATM - - - - BRCA1 + + + + CNTN6 - - - - TP53 + + + + MYCBP @@ -1057,94 +1063,112 @@ Chk1 - - - - UHRF1 - - - + Chk2 - - - - TLK1 + + + + S-Phase Progression + + + + + + ERBB2 - - - - CDC2 + + + + FBXW7 - - - - NFIB + + + + HRAS - - - - CREBBP + + + + SMARCA2 - - - - MYCBP + + + + FOXP2 - - - - NCOR1 + + + + TP53 - - - - CEBPA + + + + Apoptosis + + + + + + MAML3 - + + + + Growth Control/Homeostasis + + + + + + DNA Repair + + + MGA - - - - MAX + + + + ERBB2IP - - - - SMARCA2 + + + + SMC1A - - - - IL17RD + + + + CEBPA - - - - FGF16 + + + + Cell Growth/Migration - - - - - ERBB2IP + + + + + CREBBP @@ -1153,16 +1177,22 @@ PIK3CA - - - - ERBB2 + + + + UHRF1 - - - - HRAS + + + + MYCN + + + + + + RAF1 @@ -1171,76 +1201,76 @@ PTEN - - - - RAF1 + + + + TLK1 - + AKT1 - + + + + G2/M Progression + + + FOXO3 - - - - MAP2K2 - - - - - - CNTN6 + + + + FGF16 - - - - NOTCH1 + + + + MAX - + CTBP1 - - - - FOXP2 + + + + NOTCH1 - - - - DTX4 + + + + MAP2K2 - - - - FBXW7 + + + + BRCA1 - - - - MYCN + + + + CDC2 - - - - MAML3 + + + + NCOR1 @@ -1249,65 +1279,50 @@ Chromatin Remodeling - - - - Growth Control/Homeostasis - - - - - - DNA Repair - - - - - - Apoptosis - - - - - - S-Phase Progression - - - - - - G2/M Progression - - - - - - Growth/Proliferation + + + + IL17RD - - - - - Cell Growth/Migration + + + + + CREBBP + + + + + + + MYBL1 + + + + + + MYB + + - - - - - - HIST1H1E + + + + + + MAGI2 - - - - HIST1H2AL + + + + MAGI1 - - + + @@ -1321,48 +1336,33 @@ - - - - - - MYBL1 - - - - - - MYB + + + + + + MYCN - - - MYC - - - - MYCN - - - - - - - - MAGI1 + + + + + + HIST1H1E - - - - MAGI2 + + + + HIST1H2AL @@ -1384,15 +1384,15 @@ Apoptosis - + NICD - + Name: Pathways affected in adenoid cystic carcinoma - Last Modified: 20220416105729 + Last Modified: 20240719064745 Organism: Homo sapiens diff --git a/pathways/WP5424/WP5424-datanodes.tsv b/pathways/WP5424/WP5424-datanodes.tsv index b9e5ac90b..210970040 100644 --- a/pathways/WP5424/WP5424-datanodes.tsv +++ b/pathways/WP5424/WP5424-datanodes.tsv @@ -1,239 +1,215 @@ -Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI -15-keto-PGF2α Metabolite chebi:28442 "" wikidata:Q27103699 chebi:28442;chebi:28442 inchikey:LOLJEILMPWPILA-AMFHKTBMSA-N -Δ12-PGJ2 Metabolite chebi:28130 "Synonym: 9-Deoxy-delta(9,12)-13,14-dihydro PGD2" wikidata:Q27077015 chebi:28130;chebi:28130 inchikey:TUXFWOHFPFBNEJ-GJGHEGAFSA-N -12-oxo-10,11-dihydro-LTB4 Metabolite hmdb:HMDB0012498 "" inchikey:AHHXLFNPCWCNQF-SOOJVSLFSA-N -12(S)-HETE Metabolite chebi:34146 "" wikidata:Q2823198 chebi:34146;chebi:34146 inchikey:ZNHVWPKMFKADKW-LQWMCKPYSA-N -IP3 Metabolite chebi:16595 "" wikidata:Q26998374 chebi:16595;chebi:16595 inchikey:MMWCIQZXVOZEGG-XJTPDSDZSA-N -15(S)-HETE Metabolite chebi:15558 "" wikidata:Q21099561 chebi:15558;chebi:15558 inchikey:JSFATNQSLKRBCI-VAEKSGALSA-N -15-keto-PGI2 Metabolite chebi:15556 "=15-dehydro-Prostaglandin I2" wikidata:Q27098098 chebi:15556;chebi:15556 inchikey:YCLHGWBUIYKBPM-ABXKVQRYSA-N -10,11-dihydro-LTB4 Metabolite hmdb:HMDB0012504 "" inchikey:NKUPFHTVILUPKF-RNEQFKNCSA-N -15(R)-HpETE Metabolite chebi:82627 "" wikidata:Q27156145 chebi:82627;chebi:82627 inchikey:BFWYTORDSFIVKP-UDQWCNDOSA-N -PGA2 Metabolite chebi:27820 "PGA2=Prostaglandin A2" wikidata:Q27088462 chebi:27820;chebi:27820 inchikey:MYHXHCUNDDAEOZ-FOSBLDSVSA-N -18-COOH-dinor-LTE4 Metabolite hmdb:HMDB0012607 "" inchikey:OXCSBZDIZXLXRX-CBAWHTJISA-N -10-HOTrE Metabolite pubchem.compound:54574843 "" -5(S),6(S)-DiHETE Metabolite chebi:53026 "" wikidata:Q27123891 chebi:53026;chebi:53026 inchikey:UVZBUUTTYHTDRR-WAQVJNLQSA-N -HXA3 Metabolite chebi:36190 "" wikidata:Q100870368 chebi:36190;chebi:36190 inchikey:SGTUOBURCVMACZ-SEVPPISGSA-N -11α-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acid Metabolite chebi:73965 "" wikidata:Q27144287 chebi:73965;chebi:73965 inchikey:ZJAZCYLYLVCSNH-JHJVBQTASA-N -DH-PGJ2 Metabolite chebi:165318 "" wikidata:Q76507193 chebi:165318;chebi:165318 inchikey:BVXBMWOFDUUSEM-VADMTLSYSA-N -18-COOH-dinor-LTB4 Metabolite chebi:63980 "" wikidata:Q27132945 chebi:63980;chebi:63980 inchikey:XWRIIHRGMKHPHN-USRRKILKSA-N -Adrenic acid (22:4,w6) Metabolite chebi:53487 "" wikidata:Q4351606 chebi:53487;chebi:53487 inchikey:TWSWSIQAPQLDBP-DOFZRALJSA-N -12-oxo-LTB4 Metabolite pubchem.compound:5280876 "" wikidata:Q27103352 chebi:27814;chebi:27814 inchikey:SJVWVCVZWMJXOK-NOJHDUNKSA-N -N-acetyl- LTE4 Metabolite chebi:7210 "" wikidata:Q27107458 chebi:7210;chebi:7210 inchikey:BGGYAYMMFYBWEX-PJEAHERNSA-N -EXC4 Metabolite chebi:63984 "" wikidata:Q19597085 chebi:63984;chebi:63984 inchikey:OBQVBASHEWLKCQ-PKBWNXTMSA-N -DH-15d-PGJ2 Metabolite pubchem.compound:16061095 "=1a,1b-dihomo-15-deoxy-Δ12,14-prostaglandin J2 " wikidata:Q76507197 inchikey:MRZOOBUCSKTIRB-XVVYJDRNSA-N -PGB1 Metabolite chebi:27624 "" wikidata:Q27103232 chebi:27624;chebi:27624 inchikey:YBHMPNRDOVPQIN-VSOYFRJCSA-N -TxB1 Metabolite pubchem.compound:71668258 "" wikidata:Q27144319 chebi:73994;chebi:73994 inchikey:JSDWWNLTJCCSAV-VZBVYBAISA-N -Dihomo-y-linolenic acid (20:3,w6) Metabolite chebi:53486 "= 8,11,14-Eicosatrienoic acid =DGLA" wikidata:Q415398 chebi:53486;chebi:53486 inchikey:HOBAELRKJCKHQD-QNEBEIHSSA-N -LXB4 Metabolite lipidmaps:LMFA03040002 "" wikidata:Q4329 chebi:6499;chebi:6499 inchikey:UXVRTOKOJOMENI-WLPVFMORSA-N -15-epi-LXA4 Metabolite lipidmaps:LMFA03040010 "" wikidata:Q27074548 chebi:72789;chebi:72789 inchikey:IXAQOQZEOGMIQS-JEWNPAEBSA-N -EXD4 Metabolite chebi:63985 "" wikidata:Q19597086 chebi:63985;chebi:63985 inchikey:BUTLPEVGZIRJOA-SPCGXPCUSA-N -PGE1 Metabolite chebi:15544 "" wikidata:Q579348 chebi:15544;chebi:15544 inchikey:GMVPRGQOIOIIMI-DWKJAMRDSA-N -15(S)-HpETE Metabolite chebi:15628 "" wikidata:Q27070784 chebi:15628;chebi:15628 inchikey:BFWYTORDSFIVKP-VAEKSGALSA-N -Tetracosapentaenoic acid (24:5,w-6) Metabolite hmdb:HMDB0006322 "" chebi:77527;chebi:77527 inchikey:VENRYLMOFDSSDJ-WMPRHZDHSA-N -Bicyclo-PGE2 Metabolite chebi:89568 "" wikidata:Q27161767 chebi:89568;chebi:89568 inchikey:CGCZPIJMGKLVTQ-PAJBVNRRSA-N -16-COOH-tetranor-LTE3 Metabolite chebi:74014 "" wikidata:Q27105017 chebi:74014;chebi:74014 inchikey:LDJCPGIDJQSRGG-XFJBKEMKSA-N -5(S),6(R)-DiHETE Metabolite pubchem.compound:5283160 "" wikidata:Q76293825 chebi:138295;chebi:138295 inchikey:UVZBUUTTYHTDRR-NSEFZGNTSA-N -15-keto-13,14-dihydro-PGE1 Metabolite chebi:134499 "" wikidata:Q27283444 chebi:134499;chebi:134499 inchikey:CDUVSQMTLOYKTR-ZHALLVOQSA-N -DH-PGF2α Metabolite chebi:183014 "" chebi:183014 -EXE4 Metabolite chebi:63986 "" wikidata:Q19597087 chebi:63986;chebi:63986 inchikey:JLJNENVYAVKECZ-HRXVJLLUSA-N -TRXB3 Metabolite chebi:35032 "" wikidata:Q27116375 chebi:35032;chebi:35032 inchikey:GOHNIXDAQODZKP-OZPSOFALSA-N -13,14-dihydro-15-keto-PGD2 Metabolite chebi:72603 "DK-PGD2" wikidata:Q27070765 chebi:72603;chebi:72603 inchikey:VSRXYLYXIXYEST-KZTWKYQFSA-N -12(S)-HpETE Metabolite chebi:15626 "" wikidata:Q27070764 chebi:15626;chebi:15626 inchikey:ZIOZYRSDNLNNNJ-LQWMCKPYSA-N -15-epi-LXB4 Metabolite lipidmaps:LMFA03040007 "" wikidata:Q27132952 chebi:63991;chebi:63991 inchikey:UXVRTOKOJOMENI-SKYGSKSRSA-N -PGH2 Metabolite chebi:15554 "PGH2 is the abbreviation of PGG2" wikidata:Q416567 chebi:15554;chebi:15554 inchikey:YIBNHAJFJUQSRA-YNNPMVKQSA-N -20-COOH-LTB4 Metabolite chebi:27562 "" wikidata:Q27103196 chebi:27562;chebi:27562 inchikey:SXWGPVJGNOLNHT-VFLUTPEKSA-N -13,14-dihydro-PGF2α Metabolite chebi:88346 "" wikidata:Q27160197 chebi:88346;chebi:88346 inchikey:LLQBSJQTCKVWTD-NFUXFLSFSA-N -5(S)-HETE Metabolite chebi:28209 "" wikidata:Q2823230 chebi:28209;chebi:28209 inchikey:KGIJOOYOSFUGPC-JGKLHWIESA-N -DH-PGD2 Metabolite lipidmaps:LMFA03010156 "" wikidata:Q76507191 inchikey:GTNCJTYUJPEVBG-IBMUKCOMSA-N -DH-PGE2 Metabolite chebi:185711 "" chebi:185711 -LGE2 Metabolite chebi:34821 "Levuglandin E2" wikidata:Q27116287 chebi:34821;chebi:34821 inchikey:WJWAORNTZNRHBP-QNUMDXCLSA-N;inchikey:WJWAORNTZNRHBP-LBONXFAWSA-N -LTF4 Metabolite chebi:27491 "" wikidata:Q27103162 chebi:27491;chebi:27491 inchikey:PYSODLWHFWCFLV-VJBFNVCUSA-N -6-trans-LTB4 Metabolite chebi:63981 "" wikidata:Q27132947 chebi:63981;chebi:63981 inchikey:VNYSSYRCGWBHLG-UKNWISKWSA-N -y-linolenic acid (18:3,w6) Metabolite chebi:28661 "GLA(18:3 w6)" wikidata:Q415885 chebi:28661;chebi:28661 inchikey:VZCCETWTMQHEPK-QNEBEIHSSA-N -Ca2+ Metabolite chebi:29108 "" wikidata:Q23905776 chebi:29108;chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N -PGI2 Metabolite chebi:15552 "Synonym for PGI2 is 'Prostacyclin'" wikidata:Q412050 chebi:15552;chebi:15552 inchikey:KAQKFAOMNZTLHT-OZUDYXHBSA-N -LGD2 Metabolite chebi:34820 "Levuglandin D2" wikidata:Q6535854 chebi:34820;chebi:34820 inchikey:MLLWPVVMXGUOHD-QNUMDXCLSA-N -9α,11α-PGF2α Metabolite chebi:15553 "" wikidata:Q421375 chebi:15553;chebi:15553 inchikey:PXGPLTODNUVGFL-UAAPODJFSA-N;inchikey:PXGPLTODNUVGFL-YNNPMVKQSA-N -9α,11β-PGF2α Metabolite chebi:15553 "" wikidata:Q421375 chebi:15553;chebi:15553 inchikey:PXGPLTODNUVGFL-UAAPODJFSA-N;inchikey:PXGPLTODNUVGFL-YNNPMVKQSA-N -13,14-dihydro-15-keto-PGE2 Metabolite chebi:15550 "PGEM= Metabolites downstream of PGE2" wikidata:Q27098097 chebi:15550;chebi:15550 inchikey:CUJMXIQZWPZMNQ-XYYGWQPLSA-N;inchikey:CUJMXIQZWPZMNQ-PRDMLAEISA-N -EXA4 Metabolite chebi:63983 "" wikidata:Q19597084 chebi:63983;chebi:63983 inchikey:URDQSJSEGRMOIT-FDMWOPBLSA-N -Eicosadienoic acid (20:2,w6) Metabolite chebi:73731 "" wikidata:Q25402866 chebi:73731;chebi:73731 inchikey:XSXIVVZCUAHUJO-HZJYTTRNSA-N -PGG1 Metabolite chebi:133739 "" chebi:133739 -PGC1 Metabolite chebi:15546 "" wikidata:Q27098094 chebi:15546;chebi:15546 inchikey:PUIBPGHAXSCVRF-QHFGJBOXSA-N -Tetranor-PGDM Metabolite lipidmaps:LMFA03010221 "" wikidata:Q76614205 chebi:165343;chebi:165343 inchikey:VNJBSPJILLFAIC-BZPMIXESSA-N -PGF1α Metabolite chebi:28852 "" wikidata:Q27088352 chebi:28852;chebi:28852 inchikey:DZUXGQBLFALXCR-CDIPTNKSSA-N -TRXA3 Metabolite chebi:36203 "" wikidata:Q27104338 chebi:36203;chebi:36203 inchikey:WPLPEZUSILBTGP-CIQDQOFUSA-N -PGA1 Metabolite cas:14152-28-4 "" wikidata:Q27098093 chebi:15545;chebi:15545 inchikey:BGKHCLZFGPIKKU-LDDQNKHRSA-N -Linoleic acid (18:2,w6) Metabolite chebi:17351 "LA (18:2 w6)" wikidata:Q407426 chebi:17351;chebi:17351 inchikey:OYHQOLUKZRVURQ-HZJYTTRNSA-N -cAMP Metabolite chebi:17489 "" wikidata:Q210041 chebi:17489;chebi:17489 inchikey:IVOMOUWHDPKRLL-KQYNXXCUSA-N -15-keto-PGD2 Metabolite chebi:15557 "" wikidata:Q27098099 chebi:15557;chebi:15557 inchikey:XEQAHADLFLAPQL-RBIQQSKKSA-N -HXB3 Metabolite chebi:34784 "" wikidata:Q27116271 chebi:34784;chebi:34784 inchikey:DWNBPRRXEVJMPO-YZTVQBIISA-N;inchikey:DWNBPRRXEVJMPO-RNGYDEEPSA-N -Arachidonic Acid (20:4,w6) Metabolite chebi:15843 "" wikidata:Q407699 chebi:15843;chebi:15843 inchikey:YZXBAPSDXZZRGB-DOFZRALJSA-N -2,3 dinor-6-keto-PGF1α Metabolite chebi:73944 "" wikidata:Q27144266 chebi:73944;chebi:73944 inchikey:DNKGWNLXBRCUCF-NLOSNHEGSA-N -6-keto-PGF1α Metabolite chebi:28158 "" wikidata:Q27103534 chebi:28158;chebi:28158 inchikey:KFGOFTHODYBSGM-ZUNNJUQCSA-N -DH-15d-Δ12,14-PGD2 Metabolite chebi:165317 "" wikidata:Q76507195 chebi:165317;chebi:165317 inchikey:FGAVXMGIBNHPKY-PMRZYBNXSA-N -5(S),6(S)-epoxy-15(S)-HETE Metabolite chebi:64095 "" wikidata:Q27133027 chebi:64095;chebi:64095 inchikey:YNHSGCYEQVDEOY-UZDWIPAXSA-N -13,14-dihydro-15-keto-PGA2 Metabolite chebi:89315 "8: Prostanoid Metabolites as Biomarkers in Human Disease Helena Idborg; Sven-Christian Pawelzik. 2022. PubMed 36005592." wikidata:Q27161501 chebi:89315;chebi:89315 inchikey:FMKLAIBZMCURLI-BFVRRIQPSA-N -Ca2+ Metabolite chebi:29108 "calcium" wikidata:Q23905776 chebi:29108;chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N -9-deoxy-Δ12-PGD2* Metabolite chebi:175297 "" chebi:175297 -15-keto-13,14-dihydro-PGF2α Metabolite chebi:63976 "" wikidata:Q27070766 chebi:63976;chebi:63976 inchikey:VKTIONYPMSCHQI-XAGFEHLVSA-N -LXA4 Metabolite lipidmaps:LMFA03040001 "" wikidata:Q27082450 chebi:6498;chebi:6498 inchikey:IXAQOQZEOGMIQS-SSQFXEBMSA-N -11-dehydro-TxB2 Metabolite chebi:28667 "" wikidata:Q2806929 chebi:28667;chebi:28667 inchikey:KJYIVXDPWBUJBQ-SOGWKEBJSA-N;inchikey:KJYIVXDPWBUJBQ-UHHGALCXSA-N -6-keto-PGE1 Metabolite chebi:28269 "" wikidata:Q27103600 chebi:28269;chebi:28269 inchikey:ROUDCKODIMKLNO-CTBSXBMHSA-N -PGE2 Metabolite chebi:15551 "" wikidata:Q416554 chebi:15551;chebi:15551 inchikey:XEYBRNLFEZDVAW-ARSRFYASSA-N -Osbond acid (22:5,w6) Metabolite chebi:53488 "=docosapentaenoic acid (DPAω6, 22:5)" wikidata:Q3278345 chebi:53488;chebi:53488 inchikey:YUFFSWGQGVEMMI-JLNKQSITSA-N -Tetracosatetraenoic acid (24:4, w-6) Metabolite hmdb:HMDB0006246 "" chebi:77526;chebi:77526 inchikey:MMJZTSLHOIGZPU-DOFZRALJSA-N -20-COOH-LTE4 Metabolite pubchem.compound:53481508 "" wikidata:Q76727511 inchikey:HVLRBLGTGJGVCX-RHSCJZQUSA-N -IP3 Metabolite chebi:16595 "" wikidata:Q26998374 chebi:16595;chebi:16595 inchikey:MMWCIQZXVOZEGG-XJTPDSDZSA-N -19-OH-PGE1 Metabolite cas:55123-67-6 "" -PGD2 Metabolite chebi:15555 "" wikidata:Q419750 chebi:15555;chebi:15555 inchikey:BHMBVRSPMRCCGG-OUTUXVNYSA-N -PGH1 Metabolite chebi:91133 "" wikidata:Q27163072 chebi:91133;chebi:91133 inchikey:NTAYABHEVAQSJS-CDIPTNKSSA-N -PGJ2 Metabolite chebi:27485 "" wikidata:Q27088353 chebi:27485;chebi:27485 inchikey:UQOQENZZLBSFKO-POPPZSFYSA-N -15-keto-PGE1 Metabolite cas:22973-19-9 "" wikidata:Q27098096 chebi:15548;chebi:15548 inchikey:VXPBDCBTMSKCKZ-XQHNHVHJSA-N -PGD1 Metabolite chebi:27696 "" wikidata:Q27103269 chebi:27696;chebi:27696 inchikey:CIMMACURCPXICP-PNQRDDRVSA-N -TxA Metabolite chebi:15627 "" wikidata:Q774909 chebi:15627;chebi:15627 inchikey:DSNBHJFQCNUKMA-SCKDECHMSA-N -PGG2 Metabolite chebi:27647 "Prostaglandin G2 is abbreviated as PGG2" wikidata:Q19835971 chebi:27647;chebi:27647 inchikey:SGUKUZOVHSFKPH-YNNPMVKQSA-N -Δ6-trans-12-epi-LTB4 Metabolite chebi:63982 "" wikidata:Q27132948 chebi:63982;chebi:63982 inchikey:VNYSSYRCGWBHLG-CTOJTRLNSA-N -15-deoxy-Δ12,14-PGJ2 Metabolite chebi:34159 "=15d-PGJ2" wikidata:Q27070775 chebi:34159;chebi:34159 inchikey:VHRUMKCAEVRUBK-GODQJPCRSA-N -19-OH-PGE2 Metabolite chebi:165313 "" wikidata:Q27070797 chebi:165313;chebi:165313 inchikey:WTJYDBMHYPQFNJ-ZUVVJKHESA-N -15-keto-PGE2 Metabolite chebi:15547 "" wikidata:Q27098095 chebi:15547;chebi:15547 inchikey:YRTJDWROBKPZNV-KMXMBPPJSA-N -PGC2 Metabolite chebi:27555 "PGC2=Prostaglandin C2" wikidata:Q27103195 chebi:27555;chebi:27555 inchikey:CMBOTAQMTNMTBD-KLASNZEFSA-N -PGB2 Metabolite chebi:28099 "PGB2=Prostaglandin B2" wikidata:Q27093323 chebi:28099;chebi:28099 inchikey:PRFXRIUZNKLRHM-HKVRTXJWSA-N;inchikey:PRFXRIUZNKLRHM-RYPCXPIFSA-N -TxB Metabolite chebi:28728 "" wikidata:Q3009646 chebi:28728;chebi:28728 inchikey:XNRNNGPBEPRNAR-JQBLCGNGSA-N -cAMP Metabolite chebi:17489 "PGI2 binding to the associated IP receptor (coupled to Gs) leads to an activation of the AC and thus to an increase of intracellular cAMP. Its elevation downregulates store-mediated calcium entry, calcium mobilization and secretion, as well as platelet adhesion to subendothelial collagen via integrin α2β1. The cAMP increase further results in an activation of protein kinase-A (PKA) and in principle, in an inhibition of platelet activation. Analogous to cAMP, PKA activity has been associated with a reduced Ca2+ release from intra-platelet stores" wikidata:Q210041 chebi:17489;chebi:17489 inchikey:IVOMOUWHDPKRLL-KQYNXXCUSA-N -Membrane phospholipids Metabolite chebi:16247 "" wikidata:Q186915 chebi:16247;chebi:16247 -19-OH-6-keto-PGF1α Metabolite chebi:172589 "" chebi:172589 -6,15-Diketo-13,14-dihydro-PGF1α Metabolite chebi:72595 "" wikidata:Q27140003 chebi:72595;chebi:72595 inchikey:VGCSSPQIZFVVCH-UVBCEDGCSA-N;inchikey:VKPWUQVGTPVEMU-QVPQFPIISA-N -2,3-dinor-11β-PGF2α Metabolite chebi:165323 "" wikidata:Q106039049 chebi:165323;chebi:165323 inchikey:IDKLJIUIJUVJNR-KSJYGFEGSA-N -2,3-Dinor-TxB2 Metabolite chebi:89991 "" wikidata:Q27162208 chebi:89991;chebi:89991 inchikey:RJHNVFKNIJQTQF-LMIBIYGPSA-N -15-deoxy-Δ12,14-PGD2 Metabolite chebi:63999 "=15d-PGJ2" wikidata:Q27132957 chebi:63999;chebi:63999 inchikey:WPAYHTRLEHKDHP-UBEAGDKLSA-N -LTB4 Metabolite chebi:15647 "" wikidata:Q2704449 chebi:15647;chebi:15647 inchikey:VNYSSYRCGWBHLG-AMOLWHMGSA-N;inchikey:RRTYEHFGQWNQKK-KIQAWMAPSA-N -5(S)-HpETE Metabolite hmdb:HMDB11135 "" wikidata:Q27163174 chebi:91268;chebi:91268 inchikey:JNUUNUQHXIOFDA-XTDASVJISA-N -LTD4 Metabolite chebi:28666 "" wikidata:Q647917 chebi:28666;chebi:28666 inchikey:YEESKJGWJFYOOK-IJHYULJSSA-N -LTA4 Metabolite chebi:15651 "" wikidata:Q3024044 chebi:15651;chebi:15651 inchikey:UFPQIRYSPUYQHK-WAQVJNLQSA-N -LTE4 Metabolite chebi:15650 "" wikidata:Q2705859 chebi:15650;chebi:15650 inchikey:OTZRAYGBFWZKMX-FRFVZSDQSA-N -LTC4 Metabolite chebi:16978 "" wikidata:Q2704310 chebi:16978;chebi:16978 inchikey:GWNVDXQDILPJIG-NXOLIXFESA-N -DH-PGI2 Metabolite chebi:165328 "" wikidata:Q76534771 chebi:165328;chebi:165328 inchikey:ITVMMMCBRSJVKT-HSGSPTTCSA-N -ROS Metabolite chebi:26523 "" wikidata:Q424361 chebi:26523;chebi:26523 -20-OH-LTB4 Metabolite chebi:15646 "" wikidata:Q27071451 chebi:15646;chebi:15646 inchikey:PTJFJXLGRSTECQ-PSPARDEHSA-N -8-iso-15-keto-PGF2α Metabolite chebi:175523 "" chebi:175523 -2,3-dinor-8-IsoPGF2α Metabolite pubchem.compound:9548881 "" wikidata:Q27115927 chebi:34230;chebi:34230 inchikey:IDKLJIUIJUVJNR-JSEKUSAISA-N -8-iso-13,14-dihydro-15-keto-PGF2α Metabolite lipidmaps:LMFA03110004 "" -15-F2-IsoP Metabolite chebi:187201 "= 8-iso-PGF2a" chebi:187201 -15-D2-IsoP Metabolite lipidmaps:LMFA03110099 "Iso-Prostaglandin H2" -15-J2-IsoP Metabolite lipidmaps:LMFA03110101 "Iso-Prostaglandin H2" -15-A2-IsoP Metabolite lipidmaps:LMFA03110138 "Iso-Prostaglandin H2" -12-F2-IsoP Metabolite lipidmaps:LMFA03110042 "Iso-Prostaglandin H2" wikidata:Q76416212 inchikey:ZOCFIYOANZRNDX-GSMXCAORSA-N -12-D2-IsoP Metabolite lipidmaps:LMFA03110085 "Iso-Prostaglandin H2" -12-J2-IsoP Metabolite lipidmaps:LMFA03110087 "Iso-Prostaglandin H2" -12-15d-J2-IsoP Metabolite lipidmaps:LMFA03110090 "Iso-Prostaglandin H2" -12-E2-IsoP Metabolite lipidmaps:LMFA03110190 "Iso-Prostaglandin H2" -12-A2-IsoP Metabolite lipidmaps:LMFA03110248 "Iso-Prostaglandin H2" -8-F2-IsoP Metabolite lipidmaps:8-F2t-IsoP "" -8-D2-IsoP Metabolite lipidmaps:LMFA03110057 "Iso-Prostaglandin H2" -8-J2-IsoP Metabolite lipidmaps:LMFA03110059 "Iso-Prostaglandin H2" -8-15d-J2-IsoP Metabolite lipidbank:LMFA03110062 "Iso-Prostaglandin H2" -8-E2-IsoP Metabolite lipidmaps:LMFA03110003 "Iso-Prostaglandin H2" wikidata:Q27292182 chebi:131888;chebi:131888 inchikey:XEYBRNLFEZDVAW-CLQOMRTCSA-N -5-F2-IsoP Metabolite lipidmaps:LMFA03110039 "Iso-Prostaglandin H2" wikidata:Q76416502 inchikey:RZCPXIZGLPAGEV-VOMLHDSDSA-N -5-D2-IsoP Metabolite lipidmaps:LMFA03110070 "Iso-Prostaglandin H2" -5-J2-IsoP Metabolite lipidmaps:LMFA03110072 "Iso-Prostaglandin H2" -5-15d-J2-IsoP Metabolite lipidmaps:LMFA03110075 "Iso-Prostaglandin H2" -5-E2-IsoP Metabolite lipidmaps:LMFA03110174 "Iso-Prostaglandin H2" -5-A2-IsoP Metabolite lipidmaps:LMFA03110257 "Iso-Prostaglandin H2" -7-DH-F2-IsoP Metabolite lipidmaps:LMFA03110299 "" -14-DH-F2-IsoP Metabolite lipidmaps:LMFA03110331 "" -10-DH-F2-IsoP Metabolite lipidmaps:LMFA03110315 "" -17-DH-F2-IsoP Metabolite lipidmaps:LMFA03110347 "" -11-deoxy-13,14-dihydro-15-keto-11β,16-cyclo-PGE1 Metabolite cas:1283861-32-4 "" -Δ13-reductase GeneProduct ensembl:ENSG00000140043 "=15-oxoprostaglandin-Δ13-reductase" ensembl:ENSG00000140043 ncbigene:145482 hgnc.symbol:PTGR2 uniprot:V9HW32;uniprot:Q8N8N7;uniprot:G3V2R9 -p53 GeneProduct ensembl:ENSG00000141510 "" ensembl:ENSG00000141510 ncbigene:7157 hgnc.symbol:TP53 uniprot:E9PFT5;uniprot:A0A087WXZ1;uniprot:P04637;uniprot:A0A087X1Q1;uniprot:E7ESS1;uniprot:E7EMR6;uniprot:E7EQX7;uniprot:A0A0U1RQC9;uniprot:J3KP33;uniprot:H2EHT1;uniprot:I3L0W9;uniprot:K7PPA8;uniprot:S4R334;uniprot:A0A087WT22;uniprot:E9PCY9 -CYP4F8 GeneProduct ensembl:ENSG00000186526 "" ensembl:ENSG00000186526 ncbigene:11283 hgnc.symbol:CYP4F8 uniprot:A0A087WUC9;uniprot:A0A087WZJ1;uniprot:P98187;uniprot:A0A087WVG9 -PTGES GeneProduct ensembl:ENSG00000148344 "=microsomal prostaglandin E synthase 1 (mPGES-1)" ensembl:ENSG00000148344 ncbigene:9536 hgnc.symbol:PTGES uniprot:O14684 -PGFS GeneProduct ensembl:ENSG00000157870 "=Prostaglandin F synthase" ensembl:ENSG00000157870 ncbigene:127281 hgnc.symbol:PRXL2B uniprot:J3QKK8;uniprot:A0A0A0MT35;uniprot:A0A2P0CTH9;uniprot:Q8TBF2;uniprot:A0A0A0MRV4;uniprot:J3KRV9 -15-ketoprostaglandin reductase GeneProduct ensembl:ENSG00000140043 "" ensembl:ENSG00000140043 ncbigene:145482 hgnc.symbol:PTGR2 uniprot:V9HW32;uniprot:Q8N8N7;uniprot:G3V2R9 -NAT1 GeneProduct ensembl:ENSG00000171428 "" ensembl:ENSG00000171428 hgnc.symbol:NAT1 uniprot:F5H5R8;uniprot:P18440 -ALOX15 GeneProduct ensembl:ENSG00000161905 "" ensembl:ENSG00000161905 ncbigene:246 hgnc.symbol:ALOX15 uniprot:P16050 -SLCO2A1 GeneProduct ensembl:ENSG00000174640 "" ensembl:ENSG00000174640 ncbigene:6578 hgnc.symbol:SLCO2A1 uniprot:E7EU40;uniprot:Q92959;uniprot:F8W9W8 -PGES GeneProduct ensembl:ENSG00000148344 "=prostaglandin E synthase" ensembl:ENSG00000148344 ncbigene:9536 hgnc.symbol:PTGES uniprot:O14684 -γ-GT GeneProduct ensembl:ENSG00000100031 "Identical to GGT1
Type your comment here" ensembl:ENSG00000100031 ncbigene:2678 hgnc.symbol:GGT1 uniprot:E7ERN9;uniprot:E7ESL5;uniprot:C9JGF3;uniprot:P19440;uniprot:E7ETJ6;uniprot:E9PHP2;uniprot:B5MC34;uniprot:B5MC36;uniprot:E7EM62;uniprot:E7EVF8;uniprot:A0A140VJJ9;uniprot:E7ET76;uniprot:E7ETU4;uniprot:E7ETN1;uniprot:C9JIY6;uniprot:E7ETR7;uniprot:E7ENJ5 -TBXAS1 GeneProduct ensembl:ENSG00000059377 "=CYP5A1" ensembl:ENSG00000059377 ncbigene:6916 hgnc.symbol:TBXAS1 uniprot:A0A0C4DH47;uniprot:F8WD37;uniprot:F8WC80;uniprot:Q53F23;uniprot:P24557;uniprot:A0A0A0MSK3;uniprot:A0A498U6I9;uniprot:C9JS68 -Carboxypeptidase A GeneProduct eccode:3.4.17.1 "" -GPX1 GeneProduct ensembl:ENSG00000233276 "" ensembl:ENSG00000233276 ncbigene:2876 hgnc.symbol:GPX1 uniprot:A0A7I2UQ36;uniprot:P07203;uniprot:Q7L4Q3;uniprot:A0A2R8Y6B6;uniprot:A0A7I2YMD7 -ALOXE3 GeneProduct ensembl:ENSG00000179148 "" ensembl:ENSG00000179148 ncbigene:59344 hgnc.symbol:ALOXE3 uniprot:Q9BYJ1;uniprot:J3KPH2 -2,4-dienoyl-CoA reductase GeneProduct ensembl:ENSG00000104325 "" ensembl:ENSG00000104325 ncbigene:1666 hgnc.symbol:DECR1 uniprot:A0A024R9D7;uniprot:E5RGS6;uniprot:E5RJG7;uniprot:E5RHR1;uniprot:H0YAW3;uniprot:E5RJD2;uniprot:Q16698;uniprot:E5RID6;uniprot:E5RFV2 -EPHX2 GeneProduct ensembl:ENSG00000120915 "" ensembl:ENSG00000120915 ncbigene:2053 hgnc.symbol:EPHX2 uniprot:E5RFU2;uniprot:H0YAW7;uniprot:E5RFH6;uniprot:P34913;uniprot:E5RI53 -PGDS GeneProduct ensembl:ENSG00000107317 "=Prostaglandin D synthase" ensembl:ENSG00000107317 ncbigene:5730 hgnc.symbol:PTGDS uniprot:A0A1W2PPU3;uniprot:H0Y4L4;uniprot:A0A024R8G3;uniprot:Q5SQ11;uniprot:H0Y5A1;uniprot:P41222 -15-ketoprostaglandin reductase GeneProduct ensembl:ENSG00000140043 "" ensembl:ENSG00000140043 ncbigene:145482 hgnc.symbol:PTGR2 uniprot:V9HW32;uniprot:Q8N8N7;uniprot:G3V2R9 -ABCC4 GeneProduct ensembl:ENSG00000125257 "" ensembl:ENSG00000125257 ncbigene:10257 hgnc.symbol:ABCC4 uniprot:A0A2R8Y5Z3;uniprot:Q8IWU1;uniprot:A0A2R8YDC1;uniprot:A0A2R8YDG7;uniprot:O15439;uniprot:A0A2R8Y6V8 -PG-9KR GeneProduct ensembl:ENSG00000159228 "PG-9KR= Prostaglandin-9-ketoreductase" ensembl:ENSG00000159228 ncbigene:873 hgnc.symbol:CBR1 uniprot:A8MTM1;uniprot:P16152;uniprot:E9PQ63;uniprot:A0A384NL53 -DPEP GeneProduct eccode:1.3.4.13 "" -AKR1C3 GeneProduct ensembl:ENSG00000196139 "=aldo-keto reductase family 1 member C3" ensembl:ENSG00000196139 ncbigene:8644 hgnc.symbol:AKR1C3 uniprot:A0A0A0MSS8;uniprot:S4R3Z2;uniprot:S4R3D5;uniprot:P42330 -CYP4F8 GeneProduct ensembl:ENSG00000186526 "" ensembl:ENSG00000186526 ncbigene:11283 hgnc.symbol:CYP4F8 uniprot:A0A087WUC9;uniprot:A0A087WZJ1;uniprot:P98187;uniprot:A0A087WVG9 -H-PGDS GeneProduct ensembl:ENSG00000163106 "" ensembl:ENSG00000163106 ncbigene:27306 hgnc.symbol:HPGDS uniprot:A0A384P5J0;uniprot:O60760 -PGDS GeneProduct ensembl:ENSG00000107317 "" ensembl:ENSG00000107317 ncbigene:5730 hgnc.symbol:PTGDS uniprot:A0A1W2PPU3;uniprot:H0Y4L4;uniprot:A0A024R8G3;uniprot:Q5SQ11;uniprot:H0Y5A1;uniprot:P41222 -PGE synthase GeneProduct ensembl:ENSG00000148344 "" ensembl:ENSG00000148344 ncbigene:9536 hgnc.symbol:PTGES uniprot:O14684 -TXAS GeneProduct ensembl:ENSG00000059377 "=Thromboxane synthase" ensembl:ENSG00000059377 ncbigene:6916 hgnc.symbol:TBXAS1 uniprot:A0A0C4DH47;uniprot:F8WD37;uniprot:F8WC80;uniprot:Q53F23;uniprot:P24557;uniprot:A0A0A0MSK3;uniprot:A0A498U6I9;uniprot:C9JS68 -CYP4F8 GeneProduct ensembl:ENSG00000186526 "=cytochrome P450 family 4 subfamily F member 8" ensembl:ENSG00000186526 ncbigene:11283 hgnc.symbol:CYP4F8 uniprot:A0A087WUC9;uniprot:A0A087WZJ1;uniprot:P98187;uniprot:A0A087WVG9 -LTC4S GeneProduct ensembl:ENSG00000213316 "" ensembl:ENSG00000213316 ncbigene:4056 hgnc.symbol:LTC4S uniprot:D6RJA1;uniprot:A0A286YF10;uniprot:B5MCC3;uniprot:Q16873 -NAT2 GeneProduct ensembl:ENSG00000156006 "" ensembl:ENSG00000156006 ncbigene:10 hgnc.symbol:NAT2 uniprot:P11245;uniprot:A4Z6T7;uniprot:E7EWF9 -ALOX15B GeneProduct ensembl:ENSG00000179593 "" ensembl:ENSG00000179593 ncbigene:247 hgnc.symbol:ALOX15B uniprot:O15296;uniprot:I3L1D5 -p21 GeneProduct ensembl:ENSG00000124762 "" ensembl:ENSG00000124762 ncbigene:1026 hgnc.symbol:CDKN1A uniprot:A0A024RCX5;uniprot:P38936 -GPX1 GeneProduct ensembl:ENSG00000233276 "" ensembl:ENSG00000233276 ncbigene:2876 hgnc.symbol:GPX1 uniprot:A0A7I2UQ36;uniprot:P07203;uniprot:Q7L4Q3;uniprot:A0A2R8Y6B6;uniprot:A0A7I2YMD7 -PGES GeneProduct ensembl:ENSG00000148344 "=Prostaglandin E synthase" ensembl:ENSG00000148344 ncbigene:9536 hgnc.symbol:PTGES uniprot:O14684 -ALOX12 GeneProduct ensembl:ENSG00000108839 "" ensembl:ENSG00000108839 ncbigene:239 hgnc.symbol:ALOX12 uniprot:P18054;uniprot:K7ENN9 -ALOX12 GeneProduct ensembl:ENSG00000108839 "" ensembl:ENSG00000108839 ncbigene:239 hgnc.symbol:ALOX12 uniprot:P18054;uniprot:K7ENN9 -HPGD GeneProduct ensembl:ENSG00000164120 "15-PGDH=15-hydroxy-prostaglandin dehydrogenase" ensembl:ENSG00000164120 ncbigene:3248 hgnc.symbol:HPGD uniprot:D6RA83;uniprot:D6RHF8;uniprot:E9PD69;uniprot:E9PBZ2;uniprot:P15428;uniprot:D6RA66 -L-PGDS GeneProduct ensembl:ENSG00000107317 "" ensembl:ENSG00000107317 ncbigene:5730 hgnc.symbol:PTGDS uniprot:A0A1W2PPU3;uniprot:H0Y4L4;uniprot:A0A024R8G3;uniprot:Q5SQ11;uniprot:H0Y5A1;uniprot:P41222 -CYP8A1 GeneProduct ensembl:ENSG00000124212 "=prostaglandin I2 synthase =PTGIS" ensembl:ENSG00000124212 ncbigene:5740 hgnc.symbol:PTGIS uniprot:Q16647 -AKR1B1 GeneProduct ensembl:ENSG00000085662 "" ensembl:ENSG00000085662 ncbigene:231 hgnc.symbol:AKR1B1 uniprot:E9PEF9;uniprot:A0A024R7A8;uniprot:E9PCX2;uniprot:P15121 -AKR1C3 GeneProduct ensembl:ENSG00000196139 "=NADPH-dependent PGD2 11-ketoreductase =aldo-keto reductase family 1 member C3 =EC 1.1.1.188" ensembl:ENSG00000196139 ncbigene:8644 hgnc.symbol:AKR1C3 uniprot:A0A0A0MSS8;uniprot:S4R3Z2;uniprot:S4R3D5;uniprot:P42330 -GSTP1 GeneProduct ensembl:ENSG00000084207 "" ensembl:ENSG00000084207 ncbigene:2950 hgnc.symbol:GSTP1 uniprot:A0A087X243;uniprot:A0A087X2E9;uniprot:A0A2R8Y5E5;uniprot:A8MX94;uniprot:V9HWE9;uniprot:P09211 -GGT1 GeneProduct ensembl:ENSG00000100031 "" ensembl:ENSG00000100031 ncbigene:2678 hgnc.symbol:GGT1 uniprot:E7ERN9;uniprot:E7ESL5;uniprot:C9JGF3;uniprot:P19440;uniprot:E7ETJ6;uniprot:E9PHP2;uniprot:B5MC34;uniprot:B5MC36;uniprot:E7EM62;uniprot:E7EVF8;uniprot:A0A140VJJ9;uniprot:E7ET76;uniprot:E7ETU4;uniprot:E7ETN1;uniprot:C9JIY6;uniprot:E7ETR7;uniprot:E7ENJ5 -PTGES2 GeneProduct ensembl:ENSG00000148334 "=microsomal prostaglandin E synthase 2 (PTGES2)" ensembl:ENSG00000148334 ncbigene:80142 hgnc.symbol:PTGES2 uniprot:A0A7I2V5X6;uniprot:Q9H7Z7;uniprot:A0A7I2YQ70;uniprot:A0A7I2V5T7;uniprot:A0A7I2V308;uniprot:A0A7I2V4L3;uniprot:A0A7I2V460;uniprot:A6NHH0;uniprot:X6RJ95 -PTGES3 GeneProduct ensembl:ENSG00000110958 "=prostaglandin E synthase 3 (cPGES)" ensembl:ENSG00000110958 ncbigene:10728 hgnc.symbol:PTGES3 uniprot:A0A024RB32;uniprot:B4DDC6;uniprot:Q15185;uniprot:A0A087WYT3 -AKR1B1 GeneProduct ensembl:ENSG00000085662 "=aldo-keto reductase family 1 member B " ensembl:ENSG00000085662 ncbigene:231 hgnc.symbol:AKR1B1 uniprot:E9PEF9;uniprot:A0A024R7A8;uniprot:E9PCX2;uniprot:P15121 -p38 MAPK GeneProduct ensembl:ENSG00000185386 "" ensembl:ENSG00000185386 ncbigene:5600 hgnc.symbol:MAPK11 uniprot:F8WDP4;uniprot:Q15759 -11-hydroxythromboxane B2 dehydrogenase GeneProduct ensembl:ENSG00000165092 "11-hydroxythromboxane B2 dehydrogenase is the same as cytosolic aldehyde dehydrogenase
Type your comment here" ensembl:ENSG00000165092 ncbigene:216 hgnc.symbol:ALDH1A1 uniprot:Q5SYQ7;uniprot:V9HW83;uniprot:Q5SYQ9;uniprot:Q5SYQ8;uniprot:P00352 -PTGS1 GeneProduct ensembl:ENSG00000095303 "Prostaglandin-endoperoxide synthase 1 =cyclooxygenase (COX)" ensembl:ENSG00000095303 ncbigene:5742 hgnc.symbol:PTGS1 uniprot:A0A087X296;uniprot:A0A2R8Y6S0;uniprot:P23219;uniprot:A0A2R8YDM0;uniprot:X6RJD6 -PTGS2 GeneProduct ensembl:ENSG00000073756 "prostaglandin-endoperoxide synthase 2 =cyclooxygenase (COX)" ensembl:ENSG00000073756 ncbigene:5743 hgnc.symbol:PTGS2 uniprot:P35354;uniprot:Q6ZYK7;uniprot:A0A7P0T828 -ELOVL2 GeneProduct ensembl:ENSG00000197977 "fatty acid elongase 2" ensembl:ENSG00000197977 ncbigene:54898 hgnc.symbol:ELOVL2 uniprot:Q9NXB9;uniprot:A0A024QZV3 -ELOVL5 GeneProduct ensembl:ENSG00000012660 "fatty acid elongase 5" ensembl:ENSG00000012660 ncbigene:60481 hgnc.symbol:ELOVL5 uniprot:A0A0A0MTI6;uniprot:Q9NYP7;uniprot:A0A024RD35 -FADS2 GeneProduct ensembl:ENSG00000134824 "gene=FADS2 Δ6-Desaturase" ensembl:ENSG00000134824 ncbigene:9415 hgnc.symbol:FADS2 uniprot:O95864;uniprot:E5RGD8;uniprot:E5RGZ5;uniprot:E5RHL3 -FADS1 GeneProduct ensembl:ENSG00000149485 "Δ5-Desaturase" ensembl:ENSG00000149485 ncbigene:3992 hgnc.symbol:FADS1 uniprot:F5H2H3;uniprot:H0YB97;uniprot:F5H852;uniprot:F5H5X5;uniprot:C9JJB3;uniprot:F5H3U5;uniprot:F5H2R9;uniprot:F5H3P6;uniprot:C9J425;uniprot:F5H1Q7;uniprot:H7C2V0;uniprot:A0A0A0MR51;uniprot:F5H0Y2;uniprot:F5GWE3;uniprot:F5GYH4;uniprot:F5H8G5;uniprot:O60427 -ELOVL5 GeneProduct ensembl:ENSG00000012660 "fatty acid elongase 5" ensembl:ENSG00000012660 ncbigene:60481 hgnc.symbol:ELOVL5 uniprot:A0A0A0MTI6;uniprot:Q9NYP7;uniprot:A0A024RD35 -Δ13-reductase GeneProduct ensembl:ENSG00000140043 "=15-oxo-prostaglandin Δ13-reductase" ensembl:ENSG00000140043 ncbigene:145482 hgnc.symbol:PTGR2 uniprot:V9HW32;uniprot:Q8N8N7;uniprot:G3V2R9 -Δ13-reductase GeneProduct eccode:1.3.1.48 "=15-oxoprostaglandin-Δ13-reductase" -DPEP1 GeneProduct ensembl:ENSG00000015413 "=Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11]" ensembl:ENSG00000015413 ncbigene:1800 hgnc.symbol:DPEP1 uniprot:H3BQS5;uniprot:A0A140VJI3;uniprot:H3BP43;uniprot:P16444 -GGT1 GeneProduct ensembl:ENSG00000100031 "" ensembl:ENSG00000100031 ncbigene:2678 hgnc.symbol:GGT1 uniprot:E7ERN9;uniprot:E7ESL5;uniprot:C9JGF3;uniprot:P19440;uniprot:E7ETJ6;uniprot:E9PHP2;uniprot:B5MC34;uniprot:B5MC36;uniprot:E7EM62;uniprot:E7EVF8;uniprot:A0A140VJJ9;uniprot:E7ET76;uniprot:E7ETU4;uniprot:E7ETN1;uniprot:C9JIY6;uniprot:E7ETR7;uniprot:E7ENJ5 -DPEP2 GeneProduct ensembl:ENSG00000167261 "" ensembl:ENSG00000167261 ncbigene:64174 hgnc.symbol:DPEP2 uniprot:I3L348;uniprot:J3KSU4;uniprot:J3QLL2;uniprot:I3L4H3;uniprot:Q9H4A9 -LTC4S GeneProduct ensembl:ENSG00000213316 "" ensembl:ENSG00000213316 ncbigene:4056 hgnc.symbol:LTC4S uniprot:D6RJA1;uniprot:A0A286YF10;uniprot:B5MCC3;uniprot:Q16873 -GGT5 GeneProduct ensembl:ENSG00000099998 "=gamma-glutamyltransferase 5" ensembl:ENSG00000099998 ncbigene:2687 hgnc.symbol:GGT5 uniprot:H7C1X2;uniprot:C9JU68;uniprot:P36269 -LTA4H GeneProduct ensembl:ENSG00000111144 "" ensembl:ENSG00000111144 ncbigene:4048 hgnc.symbol:LTA4H uniprot:B4DEH5;uniprot:A0A140VK27;uniprot:P09960 -ALOX5 GeneProduct ensembl:ENSG00000012779 "=arachidonate 5-lipoxygenase" ensembl:ENSG00000012779 ncbigene:240 hgnc.symbol:ALOX5 uniprot:P09917 -FLAP GeneProduct ensembl:ENSG00000132965 "gene = ALOX5AP FLAP= 5-lipoxygenase activating protein" ensembl:ENSG00000132965 ncbigene:241 hgnc.symbol:ALOX5AP uniprot:P20292;uniprot:A0A087WW23 -HPGD GeneProduct ensembl:ENSG00000164120 "15-PGDH=15-hydroxy-prostaglandin dehydrogenase" ensembl:ENSG00000164120 ncbigene:3248 hgnc.symbol:HPGD uniprot:D6RA83;uniprot:D6RHF8;uniprot:E9PD69;uniprot:E9PBZ2;uniprot:P15428;uniprot:D6RA66 -HPGD GeneProduct ensembl:ENSG00000164120 "15-PGDH=15-hydroxy-prostaglandin dehydrogenase" ensembl:ENSG00000164120 ncbigene:3248 hgnc.symbol:HPGD uniprot:D6RA83;uniprot:D6RHF8;uniprot:E9PD69;uniprot:E9PBZ2;uniprot:P15428;uniprot:D6RA66 -HPGD GeneProduct ensembl:ENSG00000164120 "15-PGDH=15-hydroxy-prostaglandin dehydrogenase" ensembl:ENSG00000164120 ncbigene:3248 hgnc.symbol:HPGD uniprot:D6RA83;uniprot:D6RHF8;uniprot:E9PD69;uniprot:E9PBZ2;uniprot:P15428;uniprot:D6RA66 -SIRT1 GeneProduct ensembl:ENSG00000096717 "" ensembl:ENSG00000096717 ncbigene:23411 hgnc.symbol:SIRT1 uniprot:A0A024QZQ1;uniprot:E9PC49;uniprot:Q96EB6;uniprot:B0QZ35 -p53 GeneProduct ensembl:ENSG00000141510 "Gene: TP53" ensembl:ENSG00000141510 ncbigene:7157 hgnc.symbol:TP53 uniprot:E9PFT5;uniprot:A0A087WXZ1;uniprot:P04637;uniprot:A0A087X1Q1;uniprot:E7ESS1;uniprot:E7EMR6;uniprot:E7EQX7;uniprot:A0A0U1RQC9;uniprot:J3KP33;uniprot:H2EHT1;uniprot:I3L0W9;uniprot:K7PPA8;uniprot:S4R334;uniprot:A0A087WT22;uniprot:E9PCY9 -p53 GeneProduct ensembl:ENSG00000141510 "" ensembl:ENSG00000141510 ncbigene:7157 hgnc.symbol:TP53 uniprot:E9PFT5;uniprot:A0A087WXZ1;uniprot:P04637;uniprot:A0A087X1Q1;uniprot:E7ESS1;uniprot:E7EMR6;uniprot:E7EQX7;uniprot:A0A0U1RQC9;uniprot:J3KP33;uniprot:H2EHT1;uniprot:I3L0W9;uniprot:K7PPA8;uniprot:S4R334;uniprot:A0A087WT22;uniprot:E9PCY9 -p21 GeneProduct ensembl:ENSG00000124762 "Gene: CDKN1A" ensembl:ENSG00000124762 ncbigene:1026 hgnc.symbol:CDKN1A uniprot:A0A024RCX5;uniprot:P38936 -Rb GeneProduct ensembl:ENSG00000139687 "" ensembl:ENSG00000139687 ncbigene:5925 hgnc.symbol:RB1 uniprot:A0A3B3IS71;uniprot:Q92728;uniprot:A0A024RDV3;uniprot:A0A2R8YFL6;uniprot:A0A2R8Y743;uniprot:P06400 -Rb GeneProduct ensembl:ENSG00000139687 "" ensembl:ENSG00000139687 ncbigene:5925 hgnc.symbol:RB1 uniprot:A0A3B3IS71;uniprot:Q92728;uniprot:A0A024RDV3;uniprot:A0A2R8YFL6;uniprot:A0A2R8Y743;uniprot:P06400 -p53 GeneProduct ensembl:ENSG00000141510 "" ensembl:ENSG00000141510 ncbigene:7157 hgnc.symbol:TP53 uniprot:E9PFT5;uniprot:A0A087WXZ1;uniprot:P04637;uniprot:A0A087X1Q1;uniprot:E7ESS1;uniprot:E7EMR6;uniprot:E7EQX7;uniprot:A0A0U1RQC9;uniprot:J3KP33;uniprot:H2EHT1;uniprot:I3L0W9;uniprot:K7PPA8;uniprot:S4R334;uniprot:A0A087WT22;uniprot:E9PCY9 -HPGD GeneProduct ensembl:ENSG00000164120 "15-PGDH=15-hydroxy-prostaglandin dehydrogenase" ensembl:ENSG00000164120 ncbigene:3248 hgnc.symbol:HPGD uniprot:D6RA83;uniprot:D6RHF8;uniprot:E9PD69;uniprot:E9PBZ2;uniprot:P15428;uniprot:D6RA66 -ELOVL2 GeneProduct ensembl:ENSG00000197977 "fatty acid elongase 2" ensembl:ENSG00000197977 ncbigene:54898 hgnc.symbol:ELOVL2 uniprot:Q9NXB9;uniprot:A0A024QZV3 -FADS2 GeneProduct ensembl:ENSG00000134824 "gene=FADS2 Δ6-Desaturase" ensembl:ENSG00000134824 ncbigene:9415 hgnc.symbol:FADS2 uniprot:O95864;uniprot:E5RGD8;uniprot:E5RGZ5;uniprot:E5RHL3 -ALOX15 GeneProduct ensembl:ENSG00000161905 "" ensembl:ENSG00000161905 ncbigene:246 hgnc.symbol:ALOX15 uniprot:P16050 -PTGS2 GeneProduct ensembl:ENSG00000073756 "" ensembl:ENSG00000073756 ncbigene:5743 hgnc.symbol:PTGS2 uniprot:P35354;uniprot:Q6ZYK7;uniprot:A0A7P0T828 -ALOX5 GeneProduct ensembl:ENSG00000012779 "=arachidonate 5-lipoxygenase" ensembl:ENSG00000012779 ncbigene:240 hgnc.symbol:ALOX5 uniprot:P09917 -ALOX15B GeneProduct ensembl:ENSG00000179593 "" ensembl:ENSG00000179593 ncbigene:247 hgnc.symbol:ALOX15B uniprot:O15296;uniprot:I3L1D5 -ALOX15B GeneProduct ensembl:ENSG00000179593 "" ensembl:ENSG00000179593 ncbigene:247 hgnc.symbol:ALOX15B uniprot:O15296;uniprot:I3L1D5 -ALOX15 GeneProduct ensembl:ENSG00000161905 "" ensembl:ENSG00000161905 ncbigene:246 hgnc.symbol:ALOX15 uniprot:P16050 -ALOX15 GeneProduct ensembl:ENSG00000161905 "" ensembl:ENSG00000161905 ncbigene:246 hgnc.symbol:ALOX15 uniprot:P16050 -GSH Protein kegg.genes:C00051 "Cofactor" -Cytosolic phospholipase A2 Protein uniprot:P47712 "" ensembl:ENSG00000116711 ncbigene:5321 hgnc.symbol:PLA2G4A uniprot:P47712 -Cytosolic phospholipase A2 Protein uniprot:P47712 "" ensembl:ENSG00000116711 ncbigene:5321 hgnc.symbol:PLA2G4A uniprot:P47712 -CysLT1R Protein ensembl:ENSG00000173198 "=cysteinyl leukotriene type 1 receptor" ensembl:ENSG00000173198 ncbigene:10800 hgnc.symbol:CYSLTR1 uniprot:Q9Y271 -PAI-1 Protein ensembl:ENSG00000106366 "Gene: SERPINE1" ensembl:ENSG00000106366 ncbigene:5054 hgnc.symbol:SERPINE1 uniprot:A0A024QYT5;uniprot:P05121 -Cytosolic phospholipase A2 Protein uniprot:P47712 "" ensembl:ENSG00000116711 ncbigene:5321 hgnc.symbol:PLA2G4A uniprot:P47712 +Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps +15-keto-PGF2α Metabolite chebi:28442 "" wikidata:Q27103699 chebi:28442 inchikey:LOLJEILMPWPILA-AMFHKTBMSA-N pubchem.compound:5280887 chemspider:4444410 hmdb:HMDB0004240 kegg.compound:C05960 lipidmaps:LMFA03010026 +Δ12-PGJ2 Metabolite chebi:28130 "Synonym: 9-Deoxy-delta(9,12)-13,14-dihydro PGD2" wikidata:Q27077015 chebi:28130 inchikey:TUXFWOHFPFBNEJ-GJGHEGAFSA-N pubchem.compound:5280885 chemspider:4444408 hmdb:HMDB0004238 kegg.compound:C05958 lipidmaps:LMFA03010020 +12-oxo-10,11-dihydro-LTB4 Metabolite hmdb:HMDB0012498 "" inchikey:AHHXLFNPCWCNQF-SOOJVSLFSA-N pubchem.compound:53481445 chemspider:30776617 hmdb:HMDB0012498 +12(S)-HETE Metabolite chebi:34146 "" wikidata:Q2823198 chebi:34146 inchikey:ZNHVWPKMFKADKW-LQWMCKPYSA-N pubchem.compound:5283155 chemspider:4446279 hmdb:HMDB0006111 kegg.compound:C14777 lipidmaps:LMFA03060007 +IP3 Metabolite chebi:16595 "" wikidata:Q26998374 chebi:16595 inchikey:MMWCIQZXVOZEGG-XJTPDSDZSA-N pubchem.compound:439456 chemspider:388562 hmdb:HMDB0001498 kegg.compound:C01245 +15(S)-HETE Metabolite chebi:15558 "" wikidata:Q21099561 chebi:15558 inchikey:JSFATNQSLKRBCI-VAEKSGALSA-N pubchem.compound:5280724 chemspider:4444307 hmdb:HMDB0003876 kegg.compound:C04742 lipidmaps:LMFA03060001 +15-keto-PGI2 Metabolite chebi:15556 "=15-dehydro-Prostaglandin I2" wikidata:Q27098098 chebi:15556 inchikey:YCLHGWBUIYKBPM-ABXKVQRYSA-N pubchem.compound:5460107 chemspider:4573769 kegg.compound:C04835 lipidmaps:LMFA03010205 +10,11-dihydro-LTB4 Metabolite hmdb:HMDB0012504 "" inchikey:NKUPFHTVILUPKF-RNEQFKNCSA-N pubchem.compound:53481449 chemspider:30776625 hmdb:HMDB0012504 +15(R)-HpETE Metabolite chebi:82627 "" wikidata:Q27156145 chebi:82627 inchikey:BFWYTORDSFIVKP-UDQWCNDOSA-N pubchem.compound:10042663 chemspider:8218227 +PGA2 Metabolite chebi:27820 "PGA2=Prostaglandin A2" wikidata:Q27088462 chebi:27820 inchikey:MYHXHCUNDDAEOZ-FOSBLDSVSA-N pubchem.compound:5280880 chemspider:4444403 hmdb:HMDB0002752 kegg.compound:C05953 lipidmaps:LMFA03010035 +18-COOH-dinor-LTE4 Metabolite hmdb:HMDB0012607 "" inchikey:OXCSBZDIZXLXRX-CBAWHTJISA-N pubchem.compound:53481489 chemspider:30776647 hmdb:HMDB0012607 +10-HOTrE Metabolite pubchem.compound:54574843 "" +5(S),6(S)-DiHETE Metabolite chebi:53026 "" wikidata:Q27123891 chebi:53026 inchikey:UVZBUUTTYHTDRR-WAQVJNLQSA-N pubchem.compound:5283161 chemspider:4446285 lipidmaps:LMFA03060018 +HXA3 Metabolite chebi:36190 "" wikidata:Q100870368 chebi:36190 inchikey:SGTUOBURCVMACZ-SEVPPISGSA-N pubchem.compound:5283211 kegg.compound:C14808 lipidmaps:LMFA03090005 +11α-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acid Metabolite chebi:73965 "" wikidata:Q27144287 chebi:73965 inchikey:ZJAZCYLYLVCSNH-JHJVBQTASA-N pubchem.compound:161468 chemspider:141831 lipidmaps:LMFA03010032 +DH-PGJ2 Metabolite chebi:165318 "" wikidata:Q76507193 chebi:165318 inchikey:BVXBMWOFDUUSEM-VADMTLSYSA-N pubchem.compound:16061093 chemspider:17220776 lipidmaps:LMFA03010158 +18-COOH-dinor-LTB4 Metabolite chebi:63980 "" wikidata:Q27132945 chebi:63980 inchikey:XWRIIHRGMKHPHN-USRRKILKSA-N pubchem.compound:6438938 chemspider:4943376 lipidmaps:LMFA01170145;lipidmaps:LMFA05000593 +Adrenic acid (22:4,w6) Metabolite chebi:53487 "" wikidata:Q4351606 chebi:53487 inchikey:TWSWSIQAPQLDBP-DOFZRALJSA-N pubchem.compound:5497181 chemspider:4593749 hmdb:HMDB0002226 kegg.compound:C16527 lipidmaps:LMFA01030178 +12-oxo-LTB4 Metabolite pubchem.compound:5280876 "" wikidata:Q27103352 chebi:27814 inchikey:SJVWVCVZWMJXOK-NOJHDUNKSA-N pubchem.compound:5280876 chemspider:4444399 hmdb:HMDB0004234 kegg.compound:C05949 lipidmaps:LMFA03020024 +N-acetyl- LTE4 Metabolite chebi:7210 "" wikidata:Q27107458 chebi:7210 inchikey:BGGYAYMMFYBWEX-PJEAHERNSA-N pubchem.compound:5281910 chemspider:4445194 hmdb:HMDB0005084 kegg.compound:C11361 lipidmaps:LMFA03020078 +EXC4 Metabolite chebi:63984 "" wikidata:Q19597085 chebi:63984 inchikey:OBQVBASHEWLKCQ-PKBWNXTMSA-N pubchem.compound:42607303 chemspider:24822073 lipidmaps:LMFA03020031 +DH-15d-PGJ2 Metabolite pubchem.compound:16061095 "=1a,1b-dihomo-15-deoxy-Δ12,14-prostaglandin J2 " wikidata:Q76507197 inchikey:MRZOOBUCSKTIRB-XVVYJDRNSA-N pubchem.compound:16061095 lipidmaps:LMFA03010163 +PGB1 Metabolite chebi:27624 "" wikidata:Q27103232 chebi:27624 inchikey:YBHMPNRDOVPQIN-VSOYFRJCSA-N pubchem.compound:5280388 chemspider:4444076 hmdb:HMDB0002982 kegg.compound:C00959 lipidmaps:LMFA03010131 +TxB1 Metabolite pubchem.compound:71668258 "" wikidata:Q27144319 chebi:73994 inchikey:JSDWWNLTJCCSAV-VZBVYBAISA-N pubchem.compound:71668258 chemspider:29341949 +Dihomo-y-linolenic acid (20:3,w6) Metabolite chebi:53486 "= 8,11,14-Eicosatrienoic acid =DGLA" wikidata:Q415398 chebi:53486 inchikey:HOBAELRKJCKHQD-QNEBEIHSSA-N pubchem.compound:5280581 chemspider:4444199 hmdb:HMDB0002925 kegg.compound:C03242 lipidmaps:LMFA01030158 +LXB4 Metabolite lipidmaps:LMFA03040002 "" wikidata:Q4329 chebi:6499 inchikey:UXVRTOKOJOMENI-WLPVFMORSA-N pubchem.compound:5280915 chemspider:4444430 hmdb:HMDB0005082 kegg.compound:C06315 lipidmaps:LMFA03040002 +15-epi-LXA4 Metabolite lipidmaps:LMFA03040010 "" wikidata:Q27074548 chebi:72789 inchikey:IXAQOQZEOGMIQS-JEWNPAEBSA-N pubchem.compound:9841438 chemspider:8017153 hmdb:HMDB0012587 lipidmaps:LMFA03040010 +EXD4 Metabolite chebi:63985 "" wikidata:Q19597086 chebi:63985 inchikey:BUTLPEVGZIRJOA-SPCGXPCUSA-N pubchem.compound:42607304 chemspider:24822074 lipidmaps:LMFA03020032 +PGE1 Metabolite chebi:15544 "" wikidata:Q579348 chebi:15544 inchikey:GMVPRGQOIOIIMI-DWKJAMRDSA-N pubchem.compound:5280723 chemspider:4444306 hmdb:HMDB0001442 kegg.compound:C04741 lipidmaps:LMFA03010134 +15(S)-HpETE Metabolite chebi:15628 "" wikidata:Q27070784 chebi:15628 inchikey:BFWYTORDSFIVKP-VAEKSGALSA-N pubchem.compound:5280893 chemspider:4444416 hmdb:HMDB0004244 kegg.compound:C05966 lipidmaps:LMFA03060014 +Tetracosapentaenoic acid (24:5,w-6) Metabolite hmdb:HMDB0006322 "" chebi:77527 inchikey:VENRYLMOFDSSDJ-WMPRHZDHSA-N pubchem.compound:14505435 chemspider:30776541 hmdb:HMDB0006322 +Bicyclo-PGE2 Metabolite chebi:89568 "" wikidata:Q27161767 chebi:89568 inchikey:CGCZPIJMGKLVTQ-PAJBVNRRSA-N pubchem.compound:5283043 chemspider:25026867;chemspider:4446170 hmdb:HMDB0060054 lipidmaps:LMFA03010034 +16-COOH-tetranor-LTE3 Metabolite chebi:74014 "" wikidata:Q27105017 chebi:74014 inchikey:LDJCPGIDJQSRGG-XFJBKEMKSA-N pubchem.compound:6443958 chemspider:4947910 lipidmaps:LMFA03020054 +5(S),6(R)-DiHETE Metabolite pubchem.compound:5283160 "" wikidata:Q76293825 chebi:138295 inchikey:UVZBUUTTYHTDRR-NSEFZGNTSA-N pubchem.compound:5283160 lipidmaps:LMFA03060017 +15-keto-13,14-dihydro-PGE1 Metabolite chebi:134499 "" wikidata:Q27283444 chebi:134499 inchikey:CDUVSQMTLOYKTR-ZHALLVOQSA-N pubchem.compound:165284 chemspider:144898 lipidmaps:LMFA03010145 +DH-PGF2α Metabolite chebi:183014 "" chebi:183014 chemspider:4947774 lipidmaps:LMFA03010157 +EXE4 Metabolite chebi:63986 "" wikidata:Q19597087 chebi:63986 inchikey:JLJNENVYAVKECZ-HRXVJLLUSA-N pubchem.compound:52921882 chemspider:27471349 lipidmaps:LMFA03020033 +TRXB3 Metabolite chebi:35032 "" wikidata:Q27116375 chebi:35032 inchikey:GOHNIXDAQODZKP-OZPSOFALSA-N pubchem.compound:5283210 chemspider:24995661;chemspider:4446331 hmdb:HMDB0001965 kegg.compound:C14811 lipidmaps:LMFA03090004 +13,14-dihydro-15-keto-PGD2 Metabolite chebi:72603 "DK-PGD2" wikidata:Q27070765 chebi:72603 inchikey:VSRXYLYXIXYEST-KZTWKYQFSA-N pubchem.compound:5283036 chemspider:4446163 lipidmaps:LMFA03010022 +12(S)-HpETE Metabolite chebi:15626 "" wikidata:Q27070764 chebi:15626 inchikey:ZIOZYRSDNLNNNJ-LQWMCKPYSA-N pubchem.compound:5280892 chemspider:4444415 hmdb:HMDB0004243 kegg.compound:C05965 lipidmaps:LMFA03060013 +15-epi-LXB4 Metabolite lipidmaps:LMFA03040007 "" wikidata:Q27132952 chebi:63991 inchikey:UXVRTOKOJOMENI-SKYGSKSRSA-N pubchem.compound:9928453 chemspider:8104086 lipidmaps:LMFA03040007 +PGH2 Metabolite chebi:15554 "PGH2 is the abbreviation of PGG2" wikidata:Q416567 chebi:15554 inchikey:YIBNHAJFJUQSRA-YNNPMVKQSA-N pubchem.compound:445049 chemspider:21237661;chemspider:1008;chemspider:392800 hmdb:HMDB0001381 kegg.compound:C00427 lipidmaps:LMFA03010010 +20-COOH-LTB4 Metabolite chebi:27562 "" wikidata:Q27103196 chebi:27562 inchikey:SXWGPVJGNOLNHT-VFLUTPEKSA-N pubchem.compound:5280877 chemspider:4444400 hmdb:HMDB0006059 kegg.compound:C05950 lipidmaps:LMFA03020016 +13,14-dihydro-PGF2α Metabolite chebi:88346 "" wikidata:Q27160197 chebi:88346 inchikey:LLQBSJQTCKVWTD-NFUXFLSFSA-N pubchem.compound:5283080 chemspider:4446206 hmdb:HMDB0004239 lipidmaps:LMFA03010079 +5(S)-HETE Metabolite chebi:28209 "" wikidata:Q2823230 chebi:28209 inchikey:KGIJOOYOSFUGPC-JGKLHWIESA-N pubchem.compound:5280733 chemspider:4444314 hmdb:HMDB0011134 kegg.compound:C04805 lipidmaps:LMFA03060002 +DH-PGD2 Metabolite lipidmaps:LMFA03010156 "" wikidata:Q76507191 inchikey:GTNCJTYUJPEVBG-IBMUKCOMSA-N pubchem.compound:16061092 lipidmaps:LMFA03010156 +DH-PGE2 Metabolite chebi:185711 "" chebi:185711 chemspider:17220774 lipidmaps:LMFA03010155 +LGE2 Metabolite chebi:34821 "Levuglandin E2" wikidata:Q27116287 chebi:34821 inchikey:WJWAORNTZNRHBP-QNUMDXCLSA-N;inchikey:WJWAORNTZNRHBP-LBONXFAWSA-N pubchem.compound:5282261;pubchem.compound:5771742 chemspider:4696839;chemspider:30776554 hmdb:HMDB0002363 kegg.compound:C13807 lipidmaps:LMFA03100001 +LTF4 Metabolite chebi:27491 "" wikidata:Q27103162 chebi:27491 inchikey:PYSODLWHFWCFLV-VJBFNVCUSA-N pubchem.compound:5280938 chemspider:4444440 hmdb:HMDB0006465 kegg.compound:C06462 lipidmaps:LMFA03020009 +6-trans-LTB4 Metabolite chebi:63981 "" wikidata:Q27132947 chebi:63981 inchikey:VNYSSYRCGWBHLG-UKNWISKWSA-N pubchem.compound:5283128 chemspider:4446252 hmdb:HMDB0005087 lipidmaps:LMFA03020013 +y-linolenic acid (18:3,w6) Metabolite chebi:28661 "GLA(18:3 w6)" wikidata:Q415885 chebi:28661 inchikey:VZCCETWTMQHEPK-QNEBEIHSSA-N pubchem.compound:5280933 chemspider:4444436 hmdb:HMDB0003073 kegg.compound:C06426 lipidmaps:LMFA01030141 +Ca2+ Metabolite chebi:29108 "" wikidata:Q23905776 chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N pubchem.compound:271 chemspider:266 hmdb:HMDB0000464 kegg.compound:C00076 +PGI2 Metabolite chebi:15552 "Synonym for PGI2 is 'Prostacyclin'" wikidata:Q412050 chebi:15552 inchikey:KAQKFAOMNZTLHT-OZUDYXHBSA-N pubchem.compound:5282411 chemspider:4445566 hmdb:HMDB0001335 kegg.compound:C01312 lipidmaps:LMFA03010087 +LGD2 Metabolite chebi:34820 "Levuglandin D2" wikidata:Q6535854 chebi:34820 inchikey:MLLWPVVMXGUOHD-QNUMDXCLSA-N pubchem.compound:9548876 chemspider:7827799 hmdb:HMDB0002400 kegg.compound:C13808 lipidmaps:LMFA03100002 +9α,11α-PGF2α Metabolite chebi:15553 "" wikidata:Q421375 chebi:15553 inchikey:PXGPLTODNUVGFL-UAAPODJFSA-N;inchikey:PXGPLTODNUVGFL-YNNPMVKQSA-N pubchem.compound:5283078;pubchem.compound:5280363 chemspider:4446204;chemspider:4444062 hmdb:HMDB0001139 kegg.compound:C00639 lipidmaps:LMFA03010002 +9α,11β-PGF2α Metabolite chebi:15553 "" wikidata:Q421375 chebi:15553 inchikey:PXGPLTODNUVGFL-UAAPODJFSA-N;inchikey:PXGPLTODNUVGFL-YNNPMVKQSA-N pubchem.compound:5283078;pubchem.compound:5280363 chemspider:4446204;chemspider:4444062 hmdb:HMDB0001139 kegg.compound:C00639 lipidmaps:LMFA03010002 +13,14-dihydro-15-keto-PGE2 Metabolite chebi:15550 "PGEM= Metabolites downstream of PGE2" wikidata:Q27098097 chebi:15550 inchikey:CUJMXIQZWPZMNQ-XYYGWQPLSA-N;inchikey:CUJMXIQZWPZMNQ-PRDMLAEISA-N pubchem.compound:5280711;pubchem.compound:53481436 chemspider:30776612;chemspider:4444296 hmdb:HMDB0012481;hmdb:HMDB0002776 kegg.compound:C04671 lipidmaps:LMFA03010031 +EXA4 Metabolite chebi:63983 "" wikidata:Q19597084 chebi:63983 inchikey:URDQSJSEGRMOIT-FDMWOPBLSA-N pubchem.compound:52921883 chemspider:27471348 lipidmaps:LMFA03020037 +Eicosadienoic acid (20:2,w6) Metabolite chebi:73731 "" wikidata:Q25402866 chebi:73731 inchikey:XSXIVVZCUAHUJO-HZJYTTRNSA-N pubchem.compound:6439848 chemspider:4944228 hmdb:HMDB0005060 kegg.compound:C16525 lipidmaps:LMFA01031043 +PGG1 Metabolite chebi:133739 "" chebi:133739 +PGC1 Metabolite chebi:15546 "" wikidata:Q27098094 chebi:15546 inchikey:PUIBPGHAXSCVRF-QHFGJBOXSA-N pubchem.compound:5280715 chemspider:4444299 hmdb:HMDB0060104 kegg.compound:C04686 lipidmaps:LMFA03010160 +Tetranor-PGDM Metabolite lipidmaps:LMFA03010221 "" wikidata:Q76614205 chebi:165343 inchikey:VNJBSPJILLFAIC-BZPMIXESSA-N pubchem.compound:44600448 chemspider:28467789 lipidmaps:LMFA03010221 +PGF1α Metabolite chebi:28852 "" wikidata:Q27088352 chebi:28852 inchikey:DZUXGQBLFALXCR-CDIPTNKSSA-N pubchem.compound:5280939 chemspider:4444441 hmdb:HMDB0002685 kegg.compound:C06475 lipidmaps:LMFA03010137 +TRXA3 Metabolite chebi:36203 "" wikidata:Q27104338 chebi:36203 inchikey:WPLPEZUSILBTGP-CIQDQOFUSA-N pubchem.compound:5283208 chemspider:24995659;chemspider:4446329 hmdb:HMDB0001977 kegg.compound:C14809 lipidmaps:LMFA03090002 +PGA1 Metabolite cas:14152-28-4 "" wikidata:Q27098093 chebi:15545 inchikey:BGKHCLZFGPIKKU-LDDQNKHRSA-N pubchem.compound:5281912 chemspider:4445196 hmdb:HMDB0002656 kegg.compound:C04685 lipidmaps:LMFA03010005 +Linoleic acid (18:2,w6) Metabolite chebi:17351 "LA (18:2 w6)" wikidata:Q407426 chebi:17351 inchikey:OYHQOLUKZRVURQ-HZJYTTRNSA-N pubchem.compound:5280450 chemspider:4444105 hmdb:HMDB0000673 kegg.compound:C01595 lipidmaps:LMFA01030120 +cAMP Metabolite chebi:17489 "" wikidata:Q210041 chebi:17489 inchikey:IVOMOUWHDPKRLL-KQYNXXCUSA-N pubchem.compound:6076 chemspider:5851 hmdb:HMDB0000058 kegg.compound:C00575 +15-keto-PGD2 Metabolite chebi:15557 "" wikidata:Q27098099 chebi:15557 inchikey:XEQAHADLFLAPQL-RBIQQSKKSA-N pubchem.compound:5280727 chemspider:4444308 hmdb:HMDB0062297 kegg.compound:C04758 lipidmaps:LMFA03010206 +HXB3 Metabolite chebi:34784 "" wikidata:Q27116271 chebi:34784 inchikey:DWNBPRRXEVJMPO-YZTVQBIISA-N;inchikey:DWNBPRRXEVJMPO-RNGYDEEPSA-N pubchem.compound:16759353;pubchem.compound:5283209 chemspider:4446330 hmdb:HMDB0004690 kegg.compound:C14810 lipidmaps:LMFA03090003 +Arachidonic Acid (20:4,w6) Metabolite chebi:15843 "" wikidata:Q407699 chebi:15843 inchikey:YZXBAPSDXZZRGB-DOFZRALJSA-N pubchem.compound:444899 chemspider:392692 hmdb:HMDB0001043 kegg.compound:C00219 lipidmaps:LMFA01030001 +2,3 dinor-6-keto-PGF1α Metabolite chebi:73944 "" wikidata:Q27144266 chebi:73944 inchikey:DNKGWNLXBRCUCF-NLOSNHEGSA-N pubchem.compound:5283084 chemspider:4446210 hmdb:HMDB0002277;hmdb:HMDB0062618 lipidmaps:LMFA03010089 +6-keto-PGF1α Metabolite chebi:28158 "" wikidata:Q27103534 chebi:28158 inchikey:KFGOFTHODYBSGM-ZUNNJUQCSA-N pubchem.compound:5280888 chemspider:4444411 hmdb:HMDB0002886 kegg.compound:C05961 lipidmaps:LMFA03010001 +DH-15d-Δ12,14-PGD2 Metabolite chebi:165317 "" wikidata:Q76507195 chebi:165317 inchikey:FGAVXMGIBNHPKY-PMRZYBNXSA-N pubchem.compound:16061094 chemspider:17220777 lipidmaps:LMFA03010159 +5(S),6(S)-epoxy-15(S)-HETE Metabolite chebi:64095 "" wikidata:Q27133027 chebi:64095 inchikey:YNHSGCYEQVDEOY-UZDWIPAXSA-N pubchem.compound:11954060 chemspider:10128355 kegg.compound:C14815 lipidmaps:LMFA03060075 +13,14-dihydro-15-keto-PGA2 Metabolite chebi:89315 "8: Prostanoid Metabolites as Biomarkers in Human Disease Helena Idborg; Sven-Christian Pawelzik. 2022. PubMed 36005592." wikidata:Q27161501 chebi:89315 inchikey:FMKLAIBZMCURLI-BFVRRIQPSA-N pubchem.compound:5283042 chemspider:4446169 hmdb:HMDB0001244 lipidmaps:LMFA03010033 +Ca2+ Metabolite chebi:29108 "calcium" wikidata:Q23905776 chebi:29108 inchikey:BHPQYMZQTOCNFJ-UHFFFAOYSA-N pubchem.compound:271 chemspider:266 hmdb:HMDB0000464 kegg.compound:C00076 +9-deoxy-Δ12-PGD2* Metabolite chebi:175297 "" chebi:175297 +15-keto-13,14-dihydro-PGF2α Metabolite chebi:63976 "" wikidata:Q27070766 chebi:63976 inchikey:VKTIONYPMSCHQI-XAGFEHLVSA-N pubchem.compound:5283039 chemspider:4446166 hmdb:HMDB0004685 lipidmaps:LMFA03010027 +LXA4 Metabolite lipidmaps:LMFA03040001 "" wikidata:Q27082450 chebi:6498 inchikey:IXAQOQZEOGMIQS-SSQFXEBMSA-N pubchem.compound:5280914 chemspider:4444429 hmdb:HMDB0004385 kegg.compound:C06314 lipidmaps:LMFA03040001 +11-dehydro-TxB2 Metabolite chebi:28667 "" wikidata:Q2806929 chebi:28667 inchikey:KJYIVXDPWBUJBQ-SOGWKEBJSA-N;inchikey:KJYIVXDPWBUJBQ-UHHGALCXSA-N pubchem.compound:53477781;pubchem.compound:5280891 chemspider:30776537;chemspider:4444414 hmdb:HMDB0004242 kegg.compound:C05964 lipidmaps:LMFA03030004 +6-keto-PGE1 Metabolite chebi:28269 "" wikidata:Q27103600 chebi:28269 inchikey:ROUDCKODIMKLNO-CTBSXBMHSA-N pubchem.compound:5280889 chemspider:4444412 hmdb:HMDB0004241 kegg.compound:C05962 lipidmaps:LMFA03010012 +PGE2 Metabolite chebi:15551 "" wikidata:Q416554 chebi:15551 inchikey:XEYBRNLFEZDVAW-ARSRFYASSA-N pubchem.compound:5280360 chemspider:4444059 hmdb:HMDB0001220 kegg.compound:C00584 lipidmaps:LMFA03010003 +Osbond acid (22:5,w6) Metabolite chebi:53488 "=docosapentaenoic acid (DPAω6, 22:5)" wikidata:Q3278345 chebi:53488 inchikey:YUFFSWGQGVEMMI-JLNKQSITSA-N pubchem.compound:5497182 chemspider:4593750 hmdb:HMDB0006528 kegg.compound:C16513 lipidmaps:LMFA04000044 +Tetracosatetraenoic acid (24:4, w-6) Metabolite hmdb:HMDB0006246 "" chebi:77526 inchikey:MMJZTSLHOIGZPU-DOFZRALJSA-N pubchem.compound:52921800 chemspider:30776538 hmdb:HMDB0006246 +20-COOH-LTE4 Metabolite pubchem.compound:53481508 "" wikidata:Q76727511 inchikey:HVLRBLGTGJGVCX-RHSCJZQUSA-N pubchem.compound:53481508 chemspider:30776643 hmdb:HMDB0012634 lipidmaps:LMFA03020060 +19-OH-PGE1 Metabolite cas:55123-67-6 "" +PGD2 Metabolite chebi:15555 "" wikidata:Q419750 chebi:15555 inchikey:BHMBVRSPMRCCGG-OUTUXVNYSA-N pubchem.compound:448457 chemspider:395250 hmdb:HMDB0001403 kegg.compound:C00696 lipidmaps:LMFA03010004 +PGH1 Metabolite chebi:91133 "" wikidata:Q27163072 chebi:91133 inchikey:NTAYABHEVAQSJS-CDIPTNKSSA-N pubchem.compound:5283048 chemspider:4446175 hmdb:HMDB0013041 lipidmaps:LMFA03010044 +PGJ2 Metabolite chebi:27485 "" wikidata:Q27088353 chebi:27485 inchikey:UQOQENZZLBSFKO-POPPZSFYSA-N pubchem.compound:5280884 chemspider:4444407 hmdb:HMDB0002710 kegg.compound:C05957 lipidmaps:LMFA03010019 +15-keto-PGE1 Metabolite cas:22973-19-9 "" wikidata:Q27098096 chebi:15548 inchikey:VXPBDCBTMSKCKZ-XQHNHVHJSA-N pubchem.compound:5280710 chemspider:4444295 hmdb:HMDB0001320 kegg.compound:C04654 lipidmaps:LMFA03010146 +PGD1 Metabolite chebi:27696 "" wikidata:Q27103269 chebi:27696 inchikey:CIMMACURCPXICP-PNQRDDRVSA-N pubchem.compound:5280936 chemspider:4444438 hmdb:HMDB0005102 kegg.compound:C06438 lipidmaps:LMFA03010049 +TxA Metabolite chebi:15627 "" wikidata:Q774909 chebi:15627 inchikey:DSNBHJFQCNUKMA-SCKDECHMSA-N pubchem.compound:5280497 chemspider:4444137 hmdb:HMDB0001452 kegg.compound:C02198 lipidmaps:LMFA03030001 +PGG2 Metabolite chebi:27647 "Prostaglandin G2 is abbreviated as PGG2" wikidata:Q19835971 chebi:27647 inchikey:SGUKUZOVHSFKPH-YNNPMVKQSA-N pubchem.compound:5280883 chemspider:4444406 hmdb:HMDB0003235 kegg.compound:C05956 lipidmaps:LMFA03010009 +Δ6-trans-12-epi-LTB4 Metabolite chebi:63982 "" wikidata:Q27132948 chebi:63982 inchikey:VNYSSYRCGWBHLG-CTOJTRLNSA-N pubchem.compound:5283129 chemspider:4446253 hmdb:HMDB0005088 lipidmaps:LMFA03020014 +15-deoxy-Δ12,14-PGJ2 Metabolite chebi:34159 "=15d-PGJ2" wikidata:Q27070775 chebi:34159 inchikey:VHRUMKCAEVRUBK-GODQJPCRSA-N pubchem.compound:5311211 chemspider:4470730 hmdb:HMDB0005079 kegg.compound:C14717 lipidmaps:LMFA03010021 +19-OH-PGE2 Metabolite chebi:165313 "" wikidata:Q27070797 chebi:165313 inchikey:WTJYDBMHYPQFNJ-ZUVVJKHESA-N pubchem.compound:5283038 chemspider:4446165 lipidmaps:LMFA03010024 +15-keto-PGE2 Metabolite chebi:15547 "" wikidata:Q27098095 chebi:15547 inchikey:YRTJDWROBKPZNV-KMXMBPPJSA-N pubchem.compound:5280719 chemspider:4444303 hmdb:HMDB0003175 kegg.compound:C04707 lipidmaps:LMFA03010030 +PGC2 Metabolite chebi:27555 "PGC2=Prostaglandin C2" wikidata:Q27103195 chebi:27555 inchikey:CMBOTAQMTNMTBD-KLASNZEFSA-N pubchem.compound:5280882 chemspider:4444405 hmdb:HMDB0060095 kegg.compound:C05955 lipidmaps:LMFA03010133 +PGB2 Metabolite chebi:28099 "PGB2=Prostaglandin B2" wikidata:Q27093323 chebi:28099 inchikey:PRFXRIUZNKLRHM-HKVRTXJWSA-N;inchikey:PRFXRIUZNKLRHM-RYPCXPIFSA-N pubchem.compound:5288144;pubchem.compound:5280881 chemspider:4450370 hmdb:HMDB0004236 kegg.compound:C05954 lipidmaps:LMFA03010018 +TxB Metabolite chebi:28728 "" wikidata:Q3009646 chebi:28728 inchikey:XNRNNGPBEPRNAR-JQBLCGNGSA-N pubchem.compound:5283137 chemspider:4446261;chemspider:24822077 hmdb:HMDB0003252 kegg.compound:C05963 lipidmaps:LMFA03030002 +cAMP Metabolite chebi:17489 "PGI2 binding to the associated IP receptor (coupled to Gs) leads to an activation of the AC and thus to an increase of intracellular cAMP. Its elevation downregulates store-mediated calcium entry, calcium mobilization and secretion, as well as platelet adhesion to subendothelial collagen via integrin α2β1. The cAMP increase further results in an activation of protein kinase-A (PKA) and in principle, in an inhibition of platelet activation. Analogous to cAMP, PKA activity has been associated with a reduced Ca2+ release from intra-platelet stores" wikidata:Q210041 chebi:17489 inchikey:IVOMOUWHDPKRLL-KQYNXXCUSA-N pubchem.compound:6076 chemspider:5851 hmdb:HMDB0000058 kegg.compound:C00575 +Membrane phospholipids Metabolite chebi:16247 "" wikidata:Q186915 chebi:16247 kegg.compound:C00865 +19-OH-6-keto-PGF1α Metabolite chebi:172589 "" chebi:172589 +6,15-Diketo-13,14-dihydro-PGF1α Metabolite chebi:72595 "" wikidata:Q27140003 chebi:72595 inchikey:VGCSSPQIZFVVCH-UVBCEDGCSA-N;inchikey:VKPWUQVGTPVEMU-QVPQFPIISA-N pubchem.compound:5283033 chemspider:4446160 hmdb:HMDB0001968;hmdb:HMDB0001979 lipidmaps:LMFA03010013 +2,3-dinor-11β-PGF2α Metabolite chebi:165323 "" wikidata:Q106039049 chebi:165323 inchikey:IDKLJIUIJUVJNR-KSJYGFEGSA-N pubchem.compound:5283032 chemspider:4446159 lipidmaps:LMFA03010011 +2,3-Dinor-TxB2 Metabolite chebi:89991 "" wikidata:Q27162208 chebi:89991 inchikey:RJHNVFKNIJQTQF-LMIBIYGPSA-N pubchem.compound:5283138 chemspider:4446262;chemspider:24822078 hmdb:HMDB0002904 lipidmaps:LMFA03030003 +15-deoxy-Δ12,14-PGD2 Metabolite chebi:63999 "=15d-PGJ2" wikidata:Q27132957 chebi:63999 inchikey:WPAYHTRLEHKDHP-UBEAGDKLSA-N pubchem.compound:56927912 chemspider:27471353 hmdb:HMDB0060046 lipidmaps:LMFA03010051 +LTB4 Metabolite chebi:15647 "" wikidata:Q2704449 chebi:15647 inchikey:VNYSSYRCGWBHLG-AMOLWHMGSA-N;inchikey:RRTYEHFGQWNQKK-KIQAWMAPSA-N pubchem.compound:5283122;pubchem.compound:5280492 chemspider:4446246;chemspider:4444132 hmdb:HMDB0002995;hmdb:HMDB0001085 kegg.compound:C02165 lipidmaps:LMFA03020001 +5(S)-HpETE Metabolite hmdb:HMDB11135 "" wikidata:Q27163174 chebi:91268 inchikey:JNUUNUQHXIOFDA-XTDASVJISA-N pubchem.compound:5283171 chemspider:4446295 hmdb:HMDB0011135 kegg.compound:C05356 lipidmaps:LMFA03060108 +LTD4 Metabolite chebi:28666 "" wikidata:Q647917 chebi:28666 inchikey:YEESKJGWJFYOOK-IJHYULJSSA-N pubchem.compound:5280878 chemspider:4444401 hmdb:HMDB0003080 kegg.compound:C05951 lipidmaps:LMFA03020006 +LTA4 Metabolite chebi:15651 "" wikidata:Q3024044 chebi:15651 inchikey:UFPQIRYSPUYQHK-WAQVJNLQSA-N pubchem.compound:5280383 chemspider:4444074 hmdb:HMDB0001337 kegg.compound:C00909 lipidmaps:LMFA03020023 +LTE4 Metabolite chebi:15650 "" wikidata:Q2705859 chebi:15650 inchikey:OTZRAYGBFWZKMX-FRFVZSDQSA-N pubchem.compound:5280879 chemspider:4444402 hmdb:HMDB0002200 kegg.compound:C05952 lipidmaps:LMFA03020002 +LTC4 Metabolite chebi:16978 "" wikidata:Q2704310 chebi:16978 inchikey:GWNVDXQDILPJIG-NXOLIXFESA-N pubchem.compound:5280493 chemspider:4444133 hmdb:HMDB0001198 kegg.compound:C02166 lipidmaps:LMFA03020003 +DH-PGI2 Metabolite chebi:165328 "" wikidata:Q76534771 chebi:165328 inchikey:ITVMMMCBRSJVKT-HSGSPTTCSA-N pubchem.compound:42607297 chemspider:24822066 lipidmaps:LMFA03010195 +ROS Metabolite chebi:26523 "" wikidata:Q424361 chebi:26523 +20-OH-LTB4 Metabolite chebi:15646 "" wikidata:Q27071451 chebi:15646 inchikey:PTJFJXLGRSTECQ-PSPARDEHSA-N pubchem.compound:5280745 chemspider:4444320 hmdb:HMDB0001509 kegg.compound:C04853 lipidmaps:LMFA03020018 +8-iso-15-keto-PGF2α Metabolite chebi:175523 "" chebi:175523 chemspider:4446336 lipidmaps:LMFA03110005 +2,3-dinor-8-IsoPGF2α Metabolite pubchem.compound:9548881 "" wikidata:Q27115927 chebi:34230 inchikey:IDKLJIUIJUVJNR-JSEKUSAISA-N pubchem.compound:9548881 chemspider:7827804 kegg.compound:C14794 lipidmaps:LMFA03110010 +8-iso-13,14-dihydro-15-keto-PGF2α Metabolite lipidmaps:LMFA03110004 "" +15-F2-IsoP Metabolite chebi:187201 "= 8-iso-PGF2a" chebi:187201 chemspider:24841884 lipidmaps:LMFA03110015 +15-D2-IsoP Metabolite lipidmaps:LMFA03110099 "Iso-Prostaglandin H2" +15-J2-IsoP Metabolite lipidmaps:LMFA03110101 "Iso-Prostaglandin H2" +15-A2-IsoP Metabolite lipidmaps:LMFA03110138 "Iso-Prostaglandin H2" +12-F2-IsoP Metabolite lipidmaps:LMFA03110042 "Iso-Prostaglandin H2" wikidata:Q76416212 inchikey:ZOCFIYOANZRNDX-GSMXCAORSA-N pubchem.compound:10915226 lipidmaps:LMFA03110042 +12-D2-IsoP Metabolite lipidmaps:LMFA03110085 "Iso-Prostaglandin H2" +12-J2-IsoP Metabolite lipidmaps:LMFA03110087 "Iso-Prostaglandin H2" +12-15d-J2-IsoP Metabolite lipidmaps:LMFA03110090 "Iso-Prostaglandin H2" +12-E2-IsoP Metabolite lipidmaps:LMFA03110190 "Iso-Prostaglandin H2" +12-A2-IsoP Metabolite lipidmaps:LMFA03110248 "Iso-Prostaglandin H2" +8-F2-IsoP Metabolite lipidmaps:8-F2t-IsoP "" +8-D2-IsoP Metabolite lipidmaps:LMFA03110057 "Iso-Prostaglandin H2" +8-J2-IsoP Metabolite lipidmaps:LMFA03110059 "Iso-Prostaglandin H2" +8-15d-J2-IsoP Metabolite lipidbank:LMFA03110062 "Iso-Prostaglandin H2" +8-E2-IsoP Metabolite lipidmaps:LMFA03110003 "Iso-Prostaglandin H2" wikidata:Q27292182 chebi:131888 inchikey:XEYBRNLFEZDVAW-CLQOMRTCSA-N pubchem.compound:5283213 chemspider:4446334 lipidmaps:LMFA03110003 +5-F2-IsoP Metabolite lipidmaps:LMFA03110039 "Iso-Prostaglandin H2" wikidata:Q76416502 inchikey:RZCPXIZGLPAGEV-VOMLHDSDSA-N pubchem.compound:11035626 lipidmaps:LMFA03110039 +5-D2-IsoP Metabolite lipidmaps:LMFA03110070 "Iso-Prostaglandin H2" +5-J2-IsoP Metabolite lipidmaps:LMFA03110072 "Iso-Prostaglandin H2" +5-15d-J2-IsoP Metabolite lipidmaps:LMFA03110075 "Iso-Prostaglandin H2" +5-E2-IsoP Metabolite lipidmaps:LMFA03110174 "Iso-Prostaglandin H2" +5-A2-IsoP Metabolite lipidmaps:LMFA03110257 "Iso-Prostaglandin H2" +7-DH-F2-IsoP Metabolite lipidmaps:LMFA03110299 "" +14-DH-F2-IsoP Metabolite lipidmaps:LMFA03110331 "" +10-DH-F2-IsoP Metabolite lipidmaps:LMFA03110315 "" +17-DH-F2-IsoP Metabolite lipidmaps:LMFA03110347 "" +11-deoxy-13,14-dihydro-15-keto-11β,16-cyclo-PGE1 Metabolite cas:1283861-32-4 "" +Δ13-reductase GeneProduct ensembl:ENSG00000140043 "=15-oxoprostaglandin-Δ13-reductase" ensembl:ENSG00000140043 ncbigene:145482 hgnc.symbol:PTGR2 uniprot:V9HW32;uniprot:Q8N8N7;uniprot:G3V2R9 +p53 GeneProduct ensembl:ENSG00000141510 "" ensembl:ENSG00000141510 ncbigene:7157 hgnc.symbol:TP53 uniprot:E9PFT5;uniprot:A0A087WXZ1;uniprot:P04637;uniprot:A0A087X1Q1;uniprot:E7ESS1;uniprot:E7EMR6;uniprot:E7EQX7;uniprot:A0A0U1RQC9;uniprot:J3KP33;uniprot:H2EHT1;uniprot:I3L0W9;uniprot:K7PPA8;uniprot:S4R334;uniprot:A0A087WT22;uniprot:E9PCY9 +CYP4F8 GeneProduct ensembl:ENSG00000186526 "" ensembl:ENSG00000186526 ncbigene:11283 hgnc.symbol:CYP4F8 uniprot:A0A087WUC9;uniprot:A0A087WZJ1;uniprot:P98187;uniprot:A0A087WVG9 +PTGES GeneProduct ensembl:ENSG00000148344 "=microsomal prostaglandin E synthase 1 (mPGES-1)" ensembl:ENSG00000148344 ncbigene:9536 hgnc.symbol:PTGES uniprot:O14684 +PGFS GeneProduct ensembl:ENSG00000157870 "=Prostaglandin F synthase" ensembl:ENSG00000157870 ncbigene:127281 hgnc.symbol:PRXL2B uniprot:J3QKK8;uniprot:A0A0A0MT35;uniprot:A0A2P0CTH9;uniprot:Q8TBF2;uniprot:A0A0A0MRV4;uniprot:J3KRV9 +15-ketoprostaglandin reductase GeneProduct ensembl:ENSG00000140043 "" ensembl:ENSG00000140043 ncbigene:145482 hgnc.symbol:PTGR2 uniprot:V9HW32;uniprot:Q8N8N7;uniprot:G3V2R9 +NAT1 GeneProduct ensembl:ENSG00000171428 "" ensembl:ENSG00000171428 hgnc.symbol:NAT1 uniprot:F5H5R8;uniprot:P18440 +ALOX15 GeneProduct ensembl:ENSG00000161905 "" ensembl:ENSG00000161905 ncbigene:246 hgnc.symbol:ALOX15 uniprot:P16050 +SLCO2A1 GeneProduct ensembl:ENSG00000174640 "" ensembl:ENSG00000174640 ncbigene:6578 hgnc.symbol:SLCO2A1 uniprot:E7EU40;uniprot:Q92959;uniprot:F8W9W8 +PGES GeneProduct ensembl:ENSG00000148344 "=prostaglandin E synthase" ensembl:ENSG00000148344 ncbigene:9536 hgnc.symbol:PTGES uniprot:O14684 +γ-GT GeneProduct ensembl:ENSG00000100031 "Identical to GGT1" ensembl:ENSG00000100031 ncbigene:2678 hgnc.symbol:GGT1 uniprot:E7ERN9;uniprot:E7ESL5;uniprot:C9JGF3;uniprot:P19440;uniprot:E7ETJ6;uniprot:E9PHP2;uniprot:B5MC34;uniprot:B5MC36;uniprot:E7EM62;uniprot:E7EVF8;uniprot:A0A140VJJ9;uniprot:E7ET76;uniprot:E7ETU4;uniprot:E7ETN1;uniprot:C9JIY6;uniprot:E7ETR7;uniprot:E7ENJ5 +TBXAS1 GeneProduct ensembl:ENSG00000059377 "=CYP5A1" ensembl:ENSG00000059377 ncbigene:6916 hgnc.symbol:TBXAS1 uniprot:A0A0C4DH47;uniprot:F8WD37;uniprot:F8WC80;uniprot:Q53F23;uniprot:P24557;uniprot:A0A0A0MSK3;uniprot:A0A498U6I9;uniprot:C9JS68 +Carboxypeptidase A GeneProduct eccode:3.4.17.1 "" +GPX1 GeneProduct ensembl:ENSG00000233276 "" ensembl:ENSG00000233276 ncbigene:2876 hgnc.symbol:GPX1 uniprot:A0A7I2UQ36;uniprot:P07203;uniprot:Q7L4Q3;uniprot:A0A2R8Y6B6;uniprot:A0A7I2YMD7 +ALOXE3 GeneProduct ensembl:ENSG00000179148 "" ensembl:ENSG00000179148 ncbigene:59344 hgnc.symbol:ALOXE3 uniprot:Q9BYJ1;uniprot:J3KPH2 +2,4-dienoyl-CoA reductase GeneProduct ensembl:ENSG00000104325 "" ensembl:ENSG00000104325 ncbigene:1666 hgnc.symbol:DECR1 uniprot:A0A024R9D7;uniprot:E5RGS6;uniprot:E5RJG7;uniprot:E5RHR1;uniprot:H0YAW3;uniprot:E5RJD2;uniprot:Q16698;uniprot:E5RID6;uniprot:E5RFV2 +EPHX2 GeneProduct ensembl:ENSG00000120915 "" ensembl:ENSG00000120915 ncbigene:2053 hgnc.symbol:EPHX2 uniprot:E5RFU2;uniprot:H0YAW7;uniprot:E5RFH6;uniprot:P34913;uniprot:E5RI53 +PGDS GeneProduct ensembl:ENSG00000107317 "=Prostaglandin D synthase" ensembl:ENSG00000107317 ncbigene:5730 hgnc.symbol:PTGDS uniprot:A0A1W2PPU3;uniprot:H0Y4L4;uniprot:A0A024R8G3;uniprot:Q5SQ11;uniprot:H0Y5A1;uniprot:P41222 +ABCC4 GeneProduct ensembl:ENSG00000125257 "" ensembl:ENSG00000125257 ncbigene:10257 hgnc.symbol:ABCC4 uniprot:A0A2R8Y5Z3;uniprot:Q8IWU1;uniprot:A0A2R8YDC1;uniprot:A0A2R8YDG7;uniprot:O15439;uniprot:A0A2R8Y6V8 +PG-9KR GeneProduct ensembl:ENSG00000159228 "PG-9KR= Prostaglandin-9-ketoreductase" ensembl:ENSG00000159228 ncbigene:873 hgnc.symbol:CBR1 uniprot:A8MTM1;uniprot:P16152;uniprot:E9PQ63;uniprot:A0A384NL53 +DPEP GeneProduct eccode:1.3.4.13 "" +AKR1C3 GeneProduct ensembl:ENSG00000196139 "=aldo-keto reductase family 1 member C3" ensembl:ENSG00000196139 ncbigene:8644 hgnc.symbol:AKR1C3 uniprot:A0A0A0MSS8;uniprot:S4R3Z2;uniprot:S4R3D5;uniprot:P42330 +CYP4F8 GeneProduct ensembl:ENSG00000186526 "" ensembl:ENSG00000186526 ncbigene:11283 hgnc.symbol:CYP4F8 uniprot:A0A087WUC9;uniprot:A0A087WZJ1;uniprot:P98187;uniprot:A0A087WVG9 +H-PGDS GeneProduct ensembl:ENSG00000163106 "" ensembl:ENSG00000163106 ncbigene:27306 hgnc.symbol:HPGDS uniprot:A0A384P5J0;uniprot:O60760 +PGDS GeneProduct ensembl:ENSG00000107317 "" ensembl:ENSG00000107317 ncbigene:5730 hgnc.symbol:PTGDS uniprot:A0A1W2PPU3;uniprot:H0Y4L4;uniprot:A0A024R8G3;uniprot:Q5SQ11;uniprot:H0Y5A1;uniprot:P41222 +PGE synthase GeneProduct ensembl:ENSG00000148344 "" ensembl:ENSG00000148344 ncbigene:9536 hgnc.symbol:PTGES uniprot:O14684 +TXAS GeneProduct ensembl:ENSG00000059377 "=Thromboxane synthase" ensembl:ENSG00000059377 ncbigene:6916 hgnc.symbol:TBXAS1 uniprot:A0A0C4DH47;uniprot:F8WD37;uniprot:F8WC80;uniprot:Q53F23;uniprot:P24557;uniprot:A0A0A0MSK3;uniprot:A0A498U6I9;uniprot:C9JS68 +CYP4F8 GeneProduct ensembl:ENSG00000186526 "=cytochrome P450 family 4 subfamily F member 8" ensembl:ENSG00000186526 ncbigene:11283 hgnc.symbol:CYP4F8 uniprot:A0A087WUC9;uniprot:A0A087WZJ1;uniprot:P98187;uniprot:A0A087WVG9 +LTC4S GeneProduct ensembl:ENSG00000213316 "" ensembl:ENSG00000213316 ncbigene:4056 hgnc.symbol:LTC4S uniprot:D6RJA1;uniprot:A0A286YF10;uniprot:B5MCC3;uniprot:Q16873 +NAT2 GeneProduct ensembl:ENSG00000156006 "" ensembl:ENSG00000156006 ncbigene:10 hgnc.symbol:NAT2 uniprot:P11245;uniprot:A4Z6T7;uniprot:E7EWF9 +ALOX15B GeneProduct ensembl:ENSG00000179593 "" ensembl:ENSG00000179593 ncbigene:247 hgnc.symbol:ALOX15B uniprot:O15296;uniprot:I3L1D5 +p21 GeneProduct ensembl:ENSG00000124762 "" ensembl:ENSG00000124762 ncbigene:1026 hgnc.symbol:CDKN1A uniprot:A0A024RCX5;uniprot:P38936 +PGES GeneProduct ensembl:ENSG00000148344 "=Prostaglandin E synthase" ensembl:ENSG00000148344 ncbigene:9536 hgnc.symbol:PTGES uniprot:O14684 +ALOX12 GeneProduct ensembl:ENSG00000108839 "" ensembl:ENSG00000108839 ncbigene:239 hgnc.symbol:ALOX12 uniprot:P18054;uniprot:K7ENN9 +HPGD GeneProduct ensembl:ENSG00000164120 "15-PGDH=15-hydroxy-prostaglandin dehydrogenase" ensembl:ENSG00000164120 ncbigene:3248 hgnc.symbol:HPGD uniprot:D6RA83;uniprot:D6RHF8;uniprot:E9PD69;uniprot:E9PBZ2;uniprot:P15428;uniprot:D6RA66 +L-PGDS GeneProduct ensembl:ENSG00000107317 "" ensembl:ENSG00000107317 ncbigene:5730 hgnc.symbol:PTGDS uniprot:A0A1W2PPU3;uniprot:H0Y4L4;uniprot:A0A024R8G3;uniprot:Q5SQ11;uniprot:H0Y5A1;uniprot:P41222 +CYP8A1 GeneProduct ensembl:ENSG00000124212 "=prostaglandin I2 synthase =PTGIS" ensembl:ENSG00000124212 ncbigene:5740 hgnc.symbol:PTGIS uniprot:Q16647 +AKR1B1 GeneProduct ensembl:ENSG00000085662 "" ensembl:ENSG00000085662 ncbigene:231 hgnc.symbol:AKR1B1 uniprot:E9PEF9;uniprot:A0A024R7A8;uniprot:E9PCX2;uniprot:P15121 +AKR1C3 GeneProduct ensembl:ENSG00000196139 "=NADPH-dependent PGD2 11-ketoreductase =aldo-keto reductase family 1 member C3 =EC 1.1.1.188" ensembl:ENSG00000196139 ncbigene:8644 hgnc.symbol:AKR1C3 uniprot:A0A0A0MSS8;uniprot:S4R3Z2;uniprot:S4R3D5;uniprot:P42330 +GSTP1 GeneProduct ensembl:ENSG00000084207 "" ensembl:ENSG00000084207 ncbigene:2950 hgnc.symbol:GSTP1 uniprot:A0A087X243;uniprot:A0A087X2E9;uniprot:A0A2R8Y5E5;uniprot:A8MX94;uniprot:V9HWE9;uniprot:P09211 +GGT1 GeneProduct ensembl:ENSG00000100031 "" ensembl:ENSG00000100031 ncbigene:2678 hgnc.symbol:GGT1 uniprot:E7ERN9;uniprot:E7ESL5;uniprot:C9JGF3;uniprot:P19440;uniprot:E7ETJ6;uniprot:E9PHP2;uniprot:B5MC34;uniprot:B5MC36;uniprot:E7EM62;uniprot:E7EVF8;uniprot:A0A140VJJ9;uniprot:E7ET76;uniprot:E7ETU4;uniprot:E7ETN1;uniprot:C9JIY6;uniprot:E7ETR7;uniprot:E7ENJ5 +PTGES2 GeneProduct ensembl:ENSG00000148334 "=microsomal prostaglandin E synthase 2 (PTGES2)" ensembl:ENSG00000148334 ncbigene:80142 hgnc.symbol:PTGES2 uniprot:A0A7I2V5X6;uniprot:Q9H7Z7;uniprot:A0A7I2YQ70;uniprot:A0A7I2V5T7;uniprot:A0A7I2V308;uniprot:A0A7I2V4L3;uniprot:A0A7I2V460;uniprot:A6NHH0;uniprot:X6RJ95 +PTGES3 GeneProduct ensembl:ENSG00000110958 "=prostaglandin E synthase 3 (cPGES)" ensembl:ENSG00000110958 ncbigene:10728 hgnc.symbol:PTGES3 uniprot:A0A024RB32;uniprot:B4DDC6;uniprot:Q15185;uniprot:A0A087WYT3 +AKR1B1 GeneProduct ensembl:ENSG00000085662 "=aldo-keto reductase family 1 member B " ensembl:ENSG00000085662 ncbigene:231 hgnc.symbol:AKR1B1 uniprot:E9PEF9;uniprot:A0A024R7A8;uniprot:E9PCX2;uniprot:P15121 +p38 MAPK GeneProduct ensembl:ENSG00000185386 "" ensembl:ENSG00000185386 ncbigene:5600 hgnc.symbol:MAPK11 uniprot:F8WDP4;uniprot:Q15759 +11-hydroxythromboxane B2 dehydrogenase GeneProduct ensembl:ENSG00000165092 "11-hydroxythromboxane B2 dehydrogenase is the same as cytosolic aldehyde dehydrogenase" ensembl:ENSG00000165092 ncbigene:216 hgnc.symbol:ALDH1A1 uniprot:Q5SYQ7;uniprot:V9HW83;uniprot:Q5SYQ9;uniprot:Q5SYQ8;uniprot:P00352 +PTGS1 GeneProduct ensembl:ENSG00000095303 "Prostaglandin-endoperoxide synthase 1 =cyclooxygenase (COX)" ensembl:ENSG00000095303 ncbigene:5742 hgnc.symbol:PTGS1 uniprot:A0A087X296;uniprot:A0A2R8Y6S0;uniprot:P23219;uniprot:A0A2R8YDM0;uniprot:X6RJD6 +PTGS2 GeneProduct ensembl:ENSG00000073756 "prostaglandin-endoperoxide synthase 2 =cyclooxygenase (COX)" ensembl:ENSG00000073756 ncbigene:5743 hgnc.symbol:PTGS2 uniprot:P35354;uniprot:Q6ZYK7;uniprot:A0A7P0T828 +ELOVL2 GeneProduct ensembl:ENSG00000197977 "fatty acid elongase 2" ensembl:ENSG00000197977 ncbigene:54898 hgnc.symbol:ELOVL2 uniprot:Q9NXB9;uniprot:A0A024QZV3 +ELOVL5 GeneProduct ensembl:ENSG00000012660 "fatty acid elongase 5" ensembl:ENSG00000012660 ncbigene:60481 hgnc.symbol:ELOVL5 uniprot:A0A0A0MTI6;uniprot:Q9NYP7;uniprot:A0A024RD35 +FADS2 GeneProduct ensembl:ENSG00000134824 "gene=FADS2 Δ6-Desaturase" ensembl:ENSG00000134824 ncbigene:9415 hgnc.symbol:FADS2 uniprot:O95864;uniprot:E5RGD8;uniprot:E5RGZ5;uniprot:E5RHL3 +FADS1 GeneProduct ensembl:ENSG00000149485 "Δ5-Desaturase" ensembl:ENSG00000149485 ncbigene:3992 hgnc.symbol:FADS1 uniprot:F5H2H3;uniprot:H0YB97;uniprot:F5H852;uniprot:F5H5X5;uniprot:C9JJB3;uniprot:F5H3U5;uniprot:F5H2R9;uniprot:F5H3P6;uniprot:C9J425;uniprot:F5H1Q7;uniprot:H7C2V0;uniprot:A0A0A0MR51;uniprot:F5H0Y2;uniprot:F5GWE3;uniprot:F5GYH4;uniprot:F5H8G5;uniprot:O60427 +Δ13-reductase GeneProduct ensembl:ENSG00000140043 "=15-oxo-prostaglandin Δ13-reductase" ensembl:ENSG00000140043 ncbigene:145482 hgnc.symbol:PTGR2 uniprot:V9HW32;uniprot:Q8N8N7;uniprot:G3V2R9 +Δ13-reductase GeneProduct eccode:1.3.1.48 "=15-oxoprostaglandin-Δ13-reductase" +DPEP1 GeneProduct ensembl:ENSG00000015413 "=Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11]" ensembl:ENSG00000015413 ncbigene:1800 hgnc.symbol:DPEP1 uniprot:H3BQS5;uniprot:A0A140VJI3;uniprot:H3BP43;uniprot:P16444 +DPEP2 GeneProduct ensembl:ENSG00000167261 "" ensembl:ENSG00000167261 ncbigene:64174 hgnc.symbol:DPEP2 uniprot:I3L348;uniprot:J3KSU4;uniprot:J3QLL2;uniprot:I3L4H3;uniprot:Q9H4A9 +GGT5 GeneProduct ensembl:ENSG00000099998 "=gamma-glutamyltransferase 5" ensembl:ENSG00000099998 ncbigene:2687 hgnc.symbol:GGT5 uniprot:H7C1X2;uniprot:C9JU68;uniprot:P36269 +LTA4H GeneProduct ensembl:ENSG00000111144 "" ensembl:ENSG00000111144 ncbigene:4048 hgnc.symbol:LTA4H uniprot:B4DEH5;uniprot:A0A140VK27;uniprot:P09960 +ALOX5 GeneProduct ensembl:ENSG00000012779 "=arachidonate 5-lipoxygenase" ensembl:ENSG00000012779 ncbigene:240 hgnc.symbol:ALOX5 uniprot:P09917 +FLAP GeneProduct ensembl:ENSG00000132965 "gene = ALOX5AP FLAP= 5-lipoxygenase activating protein" ensembl:ENSG00000132965 ncbigene:241 hgnc.symbol:ALOX5AP uniprot:P20292;uniprot:A0A087WW23 +SIRT1 GeneProduct ensembl:ENSG00000096717 "" ensembl:ENSG00000096717 ncbigene:23411 hgnc.symbol:SIRT1 uniprot:A0A024QZQ1;uniprot:E9PC49;uniprot:Q96EB6;uniprot:B0QZ35 +p53 GeneProduct ensembl:ENSG00000141510 "Gene: TP53" ensembl:ENSG00000141510 ncbigene:7157 hgnc.symbol:TP53 uniprot:E9PFT5;uniprot:A0A087WXZ1;uniprot:P04637;uniprot:A0A087X1Q1;uniprot:E7ESS1;uniprot:E7EMR6;uniprot:E7EQX7;uniprot:A0A0U1RQC9;uniprot:J3KP33;uniprot:H2EHT1;uniprot:I3L0W9;uniprot:K7PPA8;uniprot:S4R334;uniprot:A0A087WT22;uniprot:E9PCY9 +p21 GeneProduct ensembl:ENSG00000124762 "Gene: CDKN1A" ensembl:ENSG00000124762 ncbigene:1026 hgnc.symbol:CDKN1A uniprot:A0A024RCX5;uniprot:P38936 +Rb GeneProduct ensembl:ENSG00000139687 "" ensembl:ENSG00000139687 ncbigene:5925 hgnc.symbol:RB1 uniprot:A0A3B3IS71;uniprot:Q92728;uniprot:A0A024RDV3;uniprot:A0A2R8YFL6;uniprot:A0A2R8Y743;uniprot:P06400 +PTGS2 GeneProduct ensembl:ENSG00000073756 "" ensembl:ENSG00000073756 ncbigene:5743 hgnc.symbol:PTGS2 uniprot:P35354;uniprot:Q6ZYK7;uniprot:A0A7P0T828 +GSH Protein kegg.genes:C00051 "Cofactor" +Cytosolic phospholipase A2 Protein uniprot:P47712 "" ensembl:ENSG00000116711 ncbigene:5321 hgnc.symbol:PLA2G4A uniprot:P47712 +CysLT1R Protein ensembl:ENSG00000173198 "=cysteinyl leukotriene type 1 receptor" ensembl:ENSG00000173198 ncbigene:10800 hgnc.symbol:CYSLTR1 uniprot:Q9Y271 +PAI-1 Protein ensembl:ENSG00000106366 "Gene: SERPINE1" ensembl:ENSG00000106366 ncbigene:5054 hgnc.symbol:SERPINE1 uniprot:A0A024QYT5;uniprot:P05121 diff --git a/pathways/WP5424/WP5424.gpml b/pathways/WP5424/WP5424.gpml index 46960931f..c9ee6b20f 100644 --- a/pathways/WP5424/WP5424.gpml +++ b/pathways/WP5424/WP5424.gpml @@ -1,5 +1,5 @@ - + Oxylipins, notably prostaglandins, are synthetized by senescent cells and then accumulate, promoting the senescent-associated secretory phenotype (Wiley et al., 2021). The prostaglandins are classified into three main groups, depending on the starting point of their biosynthesis. The serie-1-prostaglandins are derived from its precursor dihomo-γ-linolenic acid (DGLA). The serie-2-prostaglandins and serie-3-prostaglandins are derived from arachidonic acid (AA) and eicosapentae-noic acid (EPA), respectively (Noverr et al., 2003) @@ -185,7 +185,6 @@ Identical to GGT1 - Type your comment here @@ -1076,7 +1075,6 @@ Activation of FP by PGF2α results in the IP3 and DAG formation as well as in th 11-hydroxythromboxane B2 dehydrogenase is the same as cytosolic aldehyde dehydrogenase - Type your comment here @@ -2139,7 +2137,6 @@ FLAP= 5-lipoxygenase activating protein Reference: https://doi.org/10.1016/0165-6147(86)90312-3 - Type your comment here df6 @@ -4248,7 +4245,6 @@ FLAP= 5-lipoxygenase activating protein Enzyme is omega-oxidase: CYP4F3. There are two isoforms CYP4F3A and CYP4F3B. 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- 26026713 + + 25139562 PubMed - On the biosynthesis of 15-HETE and eoxin C4 by human airway epithelial cells. - Prostaglandins Other Lipid Mediat + Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. + Biochim Biophys Acta 2015 - Brunnström Å - Tryselius Y - Feltenmark S - Andersson E - Leksell H - James A - Mannervik B - Dahlén B - Claesson HE - - - 16862142 - PubMed - Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. - Nat Cell Biol - 2006 - Kortlever RM - Higgins PJ - Bernards R - - - 22333072 - PubMed - - - - 22333072 - PubMed - Multiple roles of dihomo-y-linolenic acid against proliferation diseases - Lipids in Health and Disease - 2012 - Xiaoping Wang - Huanping Lin - Yan Gu - - - 22002714 - PubMed - Prostaglandin E2 EP Receptors as Therapeutic Targets in Breast Cancer - - 2011 - Jocelyn Reader - Dawn Holt - Amy Fulton + Serhan CN + Dalli J + Colas RA + Winkler JW + Chiang N diff --git a/pathways/WP5424/WP5424.json b/pathways/WP5424/WP5424.json index 70ded6954..2a2dc2165 100644 --- a/pathways/WP5424/WP5424.json +++ b/pathways/WP5424/WP5424.json @@ -29,8 +29,13 @@ "TxB", "Wikidata:Q3009646", "ChEBI:28728", - "ChEBI:28728", - "InChI:XNRNNGPBEPRNAR-JQBLCGNGSA-N" + "InChI:XNRNNGPBEPRNAR-JQBLCGNGSA-N", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -71,8 +76,12 @@ "15-keto-PGF2α", "Wikidata:Q27103699", "ChEBI:28442", - "ChEBI:28442", - "InChI:LOLJEILMPWPILA-AMFHKTBMSA-N" + "InChI:LOLJEILMPWPILA-AMFHKTBMSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -160,8 +169,12 @@ "Δ12-PGJ2", "Wikidata:Q27077015", "ChEBI:28130", - "ChEBI:28130", - "InChI:TUXFWOHFPFBNEJ-GJGHEGAFSA-N" + "InChI:TUXFWOHFPFBNEJ-GJGHEGAFSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -398,7 +411,10 @@ "Metabolite", "CompactIdentifier:hmdb:HMDB0012498", "12-oxo-10,11-dihydro-LTB4", - "InChI:AHHXLFNPCWCNQF-SOOJVSLFSA-N" + "InChI:AHHXLFNPCWCNQF-SOOJVSLFSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -674,8 +690,12 @@ "12(S)-HETE", "Wikidata:Q2823198", "ChEBI:34146", - "ChEBI:34146", - "InChI:ZNHVWPKMFKADKW-LQWMCKPYSA-N" + "InChI:ZNHVWPKMFKADKW-LQWMCKPYSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -716,8 +736,11 @@ "IP3", "Wikidata:Q26998374", "ChEBI:16595", - "ChEBI:16595", - "InChI:MMWCIQZXVOZEGG-XJTPDSDZSA-N" + "InChI:MMWCIQZXVOZEGG-XJTPDSDZSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -808,7 +831,9 @@ "CompactIdentifier:lipidmaps:LMFA03110039", "5-F2-IsoP", "Wikidata:Q76416502", - "InChI:RZCPXIZGLPAGEV-VOMLHDSDSA-N" + "InChI:RZCPXIZGLPAGEV-VOMLHDSDSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -986,8 +1011,12 @@ "15(S)-HETE", "Wikidata:Q21099561", "ChEBI:15558", - "ChEBI:15558", - "InChI:JSFATNQSLKRBCI-VAEKSGALSA-N" + "InChI:JSFATNQSLKRBCI-VAEKSGALSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1083,8 +1112,11 @@ "15-keto-PGI2", "Wikidata:Q27098098", "ChEBI:15556", - "ChEBI:15556", - "InChI:YCLHGWBUIYKBPM-ABXKVQRYSA-N" + "InChI:YCLHGWBUIYKBPM-ABXKVQRYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1158,8 +1190,12 @@ "2,3-Dinor-TxB2", "Wikidata:Q27162208", "ChEBI:89991", - "ChEBI:89991", - "InChI:RJHNVFKNIJQTQF-LMIBIYGPSA-N" + "InChI:RJHNVFKNIJQTQF-LMIBIYGPSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1279,7 +1315,10 @@ "Metabolite", "CompactIdentifier:hmdb:HMDB0012504", "10,11-dihydro-LTB4", - "InChI:NKUPFHTVILUPKF-RNEQFKNCSA-N" + "InChI:NKUPFHTVILUPKF-RNEQFKNCSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -1761,8 +1800,10 @@ "DH-PGI2", "Wikidata:Q76534771", "ChEBI:165328", - "ChEBI:165328", - "InChI:ITVMMMCBRSJVKT-HSGSPTTCSA-N" + "InChI:ITVMMMCBRSJVKT-HSGSPTTCSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2233,8 +2274,9 @@ "15(R)-HpETE", "Wikidata:Q27156145", "ChEBI:82627", - "ChEBI:82627", - "InChI:BFWYTORDSFIVKP-UDQWCNDOSA-N" + "InChI:BFWYTORDSFIVKP-UDQWCNDOSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2377,8 +2419,11 @@ "2,3-dinor-8-IsoPGF2α", "Wikidata:Q27115927", "ChEBI:34230", - "ChEBI:34230", - "InChI:IDKLJIUIJUVJNR-JSEKUSAISA-N" + "InChI:IDKLJIUIJUVJNR-JSEKUSAISA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -2985,8 +3030,12 @@ "PGA2", "Wikidata:Q27088462", "ChEBI:27820", - "ChEBI:27820", - "InChI:MYHXHCUNDDAEOZ-FOSBLDSVSA-N" + "InChI:MYHXHCUNDDAEOZ-FOSBLDSVSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3025,7 +3074,10 @@ "Metabolite", "CompactIdentifier:hmdb:HMDB0012607", "18-COOH-dinor-LTE4", - "InChI:OXCSBZDIZXLXRX-CBAWHTJISA-N" + "InChI:OXCSBZDIZXLXRX-CBAWHTJISA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3216,8 +3268,10 @@ "5(S),6(S)-DiHETE", "Wikidata:Q27123891", "ChEBI:53026", - "ChEBI:53026", - "InChI:UVZBUUTTYHTDRR-WAQVJNLQSA-N" + "InChI:UVZBUUTTYHTDRR-WAQVJNLQSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3621,8 +3675,10 @@ "HXA3", "Wikidata:Q100870368", "ChEBI:36190", - "ChEBI:36190", - "InChI:SGTUOBURCVMACZ-SEVPPISGSA-N" + "InChI:SGTUOBURCVMACZ-SEVPPISGSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3813,8 +3869,10 @@ "11α-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acid", "Wikidata:Q27144287", "ChEBI:73965", - "ChEBI:73965", - "InChI:ZJAZCYLYLVCSNH-JHJVBQTASA-N" + "InChI:ZJAZCYLYLVCSNH-JHJVBQTASA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -3888,8 +3946,10 @@ "DH-PGJ2", "Wikidata:Q76507193", "ChEBI:165318", - "ChEBI:165318", - "InChI:BVXBMWOFDUUSEM-VADMTLSYSA-N" + "InChI:BVXBMWOFDUUSEM-VADMTLSYSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4037,8 +4097,11 @@ "18-COOH-dinor-LTB4", "Wikidata:Q27132945", "ChEBI:63980", - "ChEBI:63980", - "InChI:XWRIIHRGMKHPHN-USRRKILKSA-N" + "InChI:XWRIIHRGMKHPHN-USRRKILKSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4383,8 +4446,12 @@ "Adrenic acid (22:4,w6)", "Wikidata:Q4351606", "ChEBI:53487", - "ChEBI:53487", - "InChI:TWSWSIQAPQLDBP-DOFZRALJSA-N" + "InChI:TWSWSIQAPQLDBP-DOFZRALJSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4607,8 +4674,12 @@ "12-oxo-LTB4", "Wikidata:Q27103352", "ChEBI:27814", - "ChEBI:27814", - "InChI:SJVWVCVZWMJXOK-NOJHDUNKSA-N" + "InChI:SJVWVCVZWMJXOK-NOJHDUNKSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4694,8 +4765,12 @@ "N-acetyl- LTE4", "Wikidata:Q27107458", "ChEBI:7210", - "ChEBI:7210", - "InChI:BGGYAYMMFYBWEX-PJEAHERNSA-N" + "InChI:BGGYAYMMFYBWEX-PJEAHERNSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -4902,8 +4977,10 @@ "EXC4", "Wikidata:Q19597085", "ChEBI:63984", - "ChEBI:63984", - "InChI:OBQVBASHEWLKCQ-PKBWNXTMSA-N" + "InChI:OBQVBASHEWLKCQ-PKBWNXTMSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5263,7 +5340,9 @@ "CompactIdentifier:pubchem.compound:16061095", "DH-15d-PGJ2", "Wikidata:Q76507197", - "InChI:MRZOOBUCSKTIRB-XVVYJDRNSA-N" + "InChI:MRZOOBUCSKTIRB-XVVYJDRNSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5595,8 +5674,12 @@ "PGB1", "Wikidata:Q27103232", "ChEBI:27624", - "ChEBI:27624", - "InChI:YBHMPNRDOVPQIN-VSOYFRJCSA-N" + "InChI:YBHMPNRDOVPQIN-VSOYFRJCSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5673,8 +5756,12 @@ "PGC2", "Wikidata:Q27103195", "ChEBI:27555", - "ChEBI:27555", - "InChI:CMBOTAQMTNMTBD-KLASNZEFSA-N" + "InChI:CMBOTAQMTNMTBD-KLASNZEFSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5786,8 +5873,9 @@ "TxB1", "Wikidata:Q27144319", "ChEBI:73994", - "ChEBI:73994", - "InChI:JSDWWNLTJCCSAV-VZBVYBAISA-N" + "InChI:JSDWWNLTJCCSAV-VZBVYBAISA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -5998,9 +6086,6 @@ "comments": [ { "content": "Identical to GGT1" - }, - { - "content": "Type your comment here" } ], "drawAs": "rect", @@ -6716,8 +6801,12 @@ "Dihomo-y-linolenic acid (20:3,w6)", "Wikidata:Q415398", "ChEBI:53486", - "ChEBI:53486", - "InChI:HOBAELRKJCKHQD-QNEBEIHSSA-N" + "InChI:HOBAELRKJCKHQD-QNEBEIHSSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -6758,8 +6847,12 @@ "LXB4", "Wikidata:Q4329", "ChEBI:6499", - "ChEBI:6499", - "InChI:UXVRTOKOJOMENI-WLPVFMORSA-N" + "InChI:UXVRTOKOJOMENI-WLPVFMORSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -7117,8 +7210,11 @@ "15-epi-LXA4", "Wikidata:Q27074548", "ChEBI:72789", - "ChEBI:72789", - "InChI:IXAQOQZEOGMIQS-JEWNPAEBSA-N" + "InChI:IXAQOQZEOGMIQS-JEWNPAEBSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8237,8 +8333,10 @@ "EXD4", "Wikidata:Q19597086", "ChEBI:63985", - "ChEBI:63985", - "InChI:BUTLPEVGZIRJOA-SPCGXPCUSA-N" + "InChI:BUTLPEVGZIRJOA-SPCGXPCUSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8375,8 +8473,12 @@ "PGE1", "Wikidata:Q579348", "ChEBI:15544", - "ChEBI:15544", - "InChI:GMVPRGQOIOIIMI-DWKJAMRDSA-N" + "InChI:GMVPRGQOIOIIMI-DWKJAMRDSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8567,8 +8669,12 @@ "15(S)-HpETE", "Wikidata:Q27070784", "ChEBI:15628", - "ChEBI:15628", - "InChI:BFWYTORDSFIVKP-VAEKSGALSA-N" + "InChI:BFWYTORDSFIVKP-VAEKSGALSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -8608,8 +8714,10 @@ "CompactIdentifier:hmdb:HMDB0006322", "Tetracosapentaenoic acid (24:5,w-6)", "ChEBI:77527", - "ChEBI:77527", - "InChI:VENRYLMOFDSSDJ-WMPRHZDHSA-N" + "InChI:VENRYLMOFDSSDJ-WMPRHZDHSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9138,8 +9246,12 @@ "Bicyclo-PGE2", "Wikidata:Q27161767", "ChEBI:89568", - "ChEBI:89568", - "InChI:CGCZPIJMGKLVTQ-PAJBVNRRSA-N" + "InChI:CGCZPIJMGKLVTQ-PAJBVNRRSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9279,8 +9391,10 @@ "16-COOH-tetranor-LTE3", "Wikidata:Q27105017", "ChEBI:74014", - "ChEBI:74014", - "InChI:LDJCPGIDJQSRGG-XFJBKEMKSA-N" + "InChI:LDJCPGIDJQSRGG-XFJBKEMKSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9383,8 +9497,12 @@ "15-keto-PGE2", "Wikidata:Q27098095", "ChEBI:15547", - "ChEBI:15547", - "InChI:YRTJDWROBKPZNV-KMXMBPPJSA-N" + "InChI:YRTJDWROBKPZNV-KMXMBPPJSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -9662,8 +9780,9 @@ "5(S),6(R)-DiHETE", "Wikidata:Q76293825", "ChEBI:138295", - "ChEBI:138295", - "InChI:UVZBUUTTYHTDRR-NSEFZGNTSA-N" + "InChI:UVZBUUTTYHTDRR-NSEFZGNTSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10094,8 +10213,10 @@ "15-keto-13,14-dihydro-PGE1", "Wikidata:Q27283444", "ChEBI:134499", - "ChEBI:134499", - "InChI:CDUVSQMTLOYKTR-ZHALLVOQSA-N" + "InChI:CDUVSQMTLOYKTR-ZHALLVOQSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10585,7 +10706,6 @@ "CompactIdentifier:chebi:26523", "ROS", "Wikidata:Q424361", - "ChEBI:26523", "ChEBI:26523" ], "verticalAlign": "middle", @@ -10628,7 +10748,9 @@ "Metabolite", "CompactIdentifier:chebi:183014", "DH-PGF2α", - "ChEBI:183014" + "ChEBI:183014", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10716,7 +10838,9 @@ "Metabolite", "CompactIdentifier:chebi:187201", "15-F2-IsoP", - "ChEBI:187201" + "ChEBI:187201", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10757,8 +10881,10 @@ "EXE4", "Wikidata:Q19597087", "ChEBI:63986", - "ChEBI:63986", - "InChI:JLJNENVYAVKECZ-HRXVJLLUSA-N" + "InChI:JLJNENVYAVKECZ-HRXVJLLUSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -10904,8 +11030,12 @@ "LTC4", "Wikidata:Q2704310", "ChEBI:16978", - "ChEBI:16978", - "InChI:GWNVDXQDILPJIG-NXOLIXFESA-N" + "InChI:GWNVDXQDILPJIG-NXOLIXFESA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -11157,8 +11287,13 @@ "TRXB3", "Wikidata:Q27116375", "ChEBI:35032", - "ChEBI:35032", - "InChI:GOHNIXDAQODZKP-OZPSOFALSA-N" + "InChI:GOHNIXDAQODZKP-OZPSOFALSA-N", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -11359,8 +11494,10 @@ "2,3-dinor-11β-PGF2α", "Wikidata:Q106039049", "ChEBI:165323", - "ChEBI:165323", - "InChI:IDKLJIUIJUVJNR-KSJYGFEGSA-N" + "InChI:IDKLJIUIJUVJNR-KSJYGFEGSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -11490,8 +11627,12 @@ "12(S)-HpETE", "Wikidata:Q27070764", "ChEBI:15626", - "ChEBI:15626", - "InChI:ZIOZYRSDNLNNNJ-LQWMCKPYSA-N" + "InChI:ZIOZYRSDNLNNNJ-LQWMCKPYSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -11557,8 +11698,12 @@ "5(S)-HpETE", "Wikidata:Q27163174", "ChEBI:91268", - "ChEBI:91268", - "InChI:JNUUNUQHXIOFDA-XTDASVJISA-N" + "InChI:JNUUNUQHXIOFDA-XTDASVJISA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -11672,8 +11817,10 @@ "15-epi-LXB4", "Wikidata:Q27132952", "ChEBI:63991", - "ChEBI:63991", - "InChI:UXVRTOKOJOMENI-SKYGSKSRSA-N" + "InChI:UXVRTOKOJOMENI-SKYGSKSRSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -11978,8 +12125,14 @@ "PGH2", "Wikidata:Q416567", "ChEBI:15554", - "ChEBI:15554", - "InChI:YIBNHAJFJUQSRA-YNNPMVKQSA-N" + "InChI:YIBNHAJFJUQSRA-YNNPMVKQSA-N", + "", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -12259,9 +12412,16 @@ "LTB4", "Wikidata:Q2704449", "ChEBI:15647", - "ChEBI:15647", "InChI:VNYSSYRCGWBHLG-AMOLWHMGSA-N", - "InChI:RRTYEHFGQWNQKK-KIQAWMAPSA-N" + "InChI:RRTYEHFGQWNQKK-KIQAWMAPSA-N", + "", + "", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -12710,8 +12870,12 @@ "20-COOH-LTB4", "Wikidata:Q27103196", "ChEBI:27562", - "ChEBI:27562", - "InChI:SXWGPVJGNOLNHT-VFLUTPEKSA-N" + "InChI:SXWGPVJGNOLNHT-VFLUTPEKSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -12808,8 +12972,11 @@ "13,14-dihydro-PGF2α", "Wikidata:Q27160197", "ChEBI:88346", - "ChEBI:88346", - "InChI:LLQBSJQTCKVWTD-NFUXFLSFSA-N" + "InChI:LLQBSJQTCKVWTD-NFUXFLSFSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -12984,8 +13151,12 @@ "5(S)-HETE", "Wikidata:Q2823230", "ChEBI:28209", - "ChEBI:28209", - "InChI:KGIJOOYOSFUGPC-JGKLHWIESA-N" + "InChI:KGIJOOYOSFUGPC-JGKLHWIESA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -13058,7 +13229,9 @@ "CompactIdentifier:lipidmaps:LMFA03010156", "DH-PGD2", "Wikidata:Q76507191", - "InChI:GTNCJTYUJPEVBG-IBMUKCOMSA-N" + "InChI:GTNCJTYUJPEVBG-IBMUKCOMSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -13516,7 +13689,9 @@ "Metabolite", "CompactIdentifier:chebi:185711", "DH-PGE2", - "ChEBI:185711" + "ChEBI:185711", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -13769,8 +13944,12 @@ "LTA4", "Wikidata:Q3024044", "ChEBI:15651", - "ChEBI:15651", - "InChI:UFPQIRYSPUYQHK-WAQVJNLQSA-N" + "InChI:UFPQIRYSPUYQHK-WAQVJNLQSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -14402,9 +14581,15 @@ "LGE2", "Wikidata:Q27116287", "ChEBI:34821", - "ChEBI:34821", "InChI:WJWAORNTZNRHBP-QNUMDXCLSA-N", - "InChI:WJWAORNTZNRHBP-LBONXFAWSA-N" + "InChI:WJWAORNTZNRHBP-LBONXFAWSA-N", + "", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -14664,8 +14849,12 @@ "LTF4", "Wikidata:Q27103162", "ChEBI:27491", - "ChEBI:27491", - "InChI:PYSODLWHFWCFLV-VJBFNVCUSA-N" + "InChI:PYSODLWHFWCFLV-VJBFNVCUSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -15067,8 +15256,11 @@ "6-trans-LTB4", "Wikidata:Q27132947", "ChEBI:63981", - "ChEBI:63981", - "InChI:VNYSSYRCGWBHLG-UKNWISKWSA-N" + "InChI:VNYSSYRCGWBHLG-UKNWISKWSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -15595,8 +15787,10 @@ "8-E2-IsoP", "Wikidata:Q27292182", "ChEBI:131888", - "ChEBI:131888", - "InChI:XEYBRNLFEZDVAW-CLQOMRTCSA-N" + "InChI:XEYBRNLFEZDVAW-CLQOMRTCSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -15827,8 +16021,12 @@ "y-linolenic acid (18:3,w6)", "Wikidata:Q415885", "ChEBI:28661", - "ChEBI:28661", - "InChI:VZCCETWTMQHEPK-QNEBEIHSSA-N" + "InChI:VZCCETWTMQHEPK-QNEBEIHSSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -16347,8 +16545,11 @@ "Ca2+", "Wikidata:Q23905776", "ChEBI:29108", - "ChEBI:29108", - "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N" + "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -16628,8 +16829,12 @@ "PGI2", "Wikidata:Q412050", "ChEBI:15552", - "ChEBI:15552", - "InChI:KAQKFAOMNZTLHT-OZUDYXHBSA-N" + "InChI:KAQKFAOMNZTLHT-OZUDYXHBSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -16934,8 +17139,12 @@ "LGD2", "Wikidata:Q6535854", "ChEBI:34820", - "ChEBI:34820", - "InChI:MLLWPVVMXGUOHD-QNUMDXCLSA-N" + "InChI:MLLWPVVMXGUOHD-QNUMDXCLSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -17322,9 +17531,15 @@ "9α,11α-PGF2α", "Wikidata:Q421375", "ChEBI:15553", - "ChEBI:15553", "InChI:PXGPLTODNUVGFL-UAAPODJFSA-N", - "InChI:PXGPLTODNUVGFL-YNNPMVKQSA-N" + "InChI:PXGPLTODNUVGFL-YNNPMVKQSA-N", + "", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -17415,9 +17630,15 @@ "9α,11β-PGF2α", "Wikidata:Q421375", "ChEBI:15553", - "ChEBI:15553", "InChI:PXGPLTODNUVGFL-UAAPODJFSA-N", - "InChI:PXGPLTODNUVGFL-YNNPMVKQSA-N" + "InChI:PXGPLTODNUVGFL-YNNPMVKQSA-N", + "", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -18045,9 +18266,16 @@ "13,14-dihydro-15-keto-PGE2", "Wikidata:Q27098097", "ChEBI:15550", - "ChEBI:15550", "InChI:CUJMXIQZWPZMNQ-XYYGWQPLSA-N", - "InChI:CUJMXIQZWPZMNQ-PRDMLAEISA-N" + "InChI:CUJMXIQZWPZMNQ-PRDMLAEISA-N", + "", + "", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -18126,8 +18354,10 @@ "EXA4", "Wikidata:Q19597084", "ChEBI:63983", - "ChEBI:63983", - "InChI:URDQSJSEGRMOIT-FDMWOPBLSA-N" + "InChI:URDQSJSEGRMOIT-FDMWOPBLSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -18477,7 +18707,9 @@ "CompactIdentifier:lipidmaps:LMFA03110042", "12-F2-IsoP", "Wikidata:Q76416212", - "InChI:ZOCFIYOANZRNDX-GSMXCAORSA-N" + "InChI:ZOCFIYOANZRNDX-GSMXCAORSA-N", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -18873,8 +19105,12 @@ "Eicosadienoic acid (20:2,w6)", "Wikidata:Q25402866", "ChEBI:73731", - "ChEBI:73731", - "InChI:XSXIVVZCUAHUJO-HZJYTTRNSA-N" + "InChI:XSXIVVZCUAHUJO-HZJYTTRNSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -18990,9 +19226,6 @@ "comments": [ { "content": "11-hydroxythromboxane B2 dehydrogenase is the same as cytosolic aldehyde dehydrogenase" - }, - { - "content": "Type your comment here" } ], "drawAs": "rect", @@ -19543,8 +19776,12 @@ "PGC1", "Wikidata:Q27098094", "ChEBI:15546", - "ChEBI:15546", - "InChI:PUIBPGHAXSCVRF-QHFGJBOXSA-N" + "InChI:PUIBPGHAXSCVRF-QHFGJBOXSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -19687,8 +19924,10 @@ "Tetranor-PGDM", "Wikidata:Q76614205", "ChEBI:165343", - "ChEBI:165343", - "InChI:VNJBSPJILLFAIC-BZPMIXESSA-N" + "InChI:VNJBSPJILLFAIC-BZPMIXESSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -20114,7 +20353,9 @@ "Metabolite", "CompactIdentifier:chebi:175523", "8-iso-15-keto-PGF2α", - "ChEBI:175523" + "ChEBI:175523", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -20188,8 +20429,12 @@ "PGF1α", "Wikidata:Q27088352", "ChEBI:28852", - "ChEBI:28852", - "InChI:DZUXGQBLFALXCR-CDIPTNKSSA-N" + "InChI:DZUXGQBLFALXCR-CDIPTNKSSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -20230,8 +20475,13 @@ "TRXA3", "Wikidata:Q27104338", "ChEBI:36203", - "ChEBI:36203", - "InChI:WPLPEZUSILBTGP-CIQDQOFUSA-N" + "InChI:WPLPEZUSILBTGP-CIQDQOFUSA-N", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -21016,8 +21266,12 @@ "20-OH-LTB4", "Wikidata:Q27071451", "ChEBI:15646", - "ChEBI:15646", - "InChI:PTJFJXLGRSTECQ-PSPARDEHSA-N" + "InChI:PTJFJXLGRSTECQ-PSPARDEHSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -21272,8 +21526,12 @@ "PGA1", "Wikidata:Q27098093", "ChEBI:15545", - "ChEBI:15545", - "InChI:BGKHCLZFGPIKKU-LDDQNKHRSA-N" + "InChI:BGKHCLZFGPIKKU-LDDQNKHRSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -21536,8 +21794,11 @@ "cAMP", "Wikidata:Q210041", "ChEBI:17489", - "ChEBI:17489", - "InChI:IVOMOUWHDPKRLL-KQYNXXCUSA-N" + "InChI:IVOMOUWHDPKRLL-KQYNXXCUSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -22410,8 +22671,12 @@ "Linoleic acid (18:2,w6)", "Wikidata:Q407426", "ChEBI:17351", - "ChEBI:17351", - "InChI:OYHQOLUKZRVURQ-HZJYTTRNSA-N" + "InChI:OYHQOLUKZRVURQ-HZJYTTRNSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -22565,8 +22830,11 @@ "cAMP", "Wikidata:Q210041", "ChEBI:17489", - "ChEBI:17489", - "InChI:IVOMOUWHDPKRLL-KQYNXXCUSA-N" + "InChI:IVOMOUWHDPKRLL-KQYNXXCUSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -22648,8 +22916,12 @@ "15-keto-PGD2", "Wikidata:Q27098099", "ChEBI:15557", - "ChEBI:15557", - "InChI:XEQAHADLFLAPQL-RBIQQSKKSA-N" + "InChI:XEQAHADLFLAPQL-RBIQQSKKSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -23044,7 +23316,7 @@ "Membrane phospholipids", "Wikidata:Q186915", "ChEBI:16247", - "ChEBI:16247" + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -23637,9 +23909,14 @@ "HXB3", "Wikidata:Q27116271", "ChEBI:34784", - "ChEBI:34784", "InChI:DWNBPRRXEVJMPO-YZTVQBIISA-N", - "InChI:DWNBPRRXEVJMPO-RNGYDEEPSA-N" + "InChI:DWNBPRRXEVJMPO-RNGYDEEPSA-N", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -23680,8 +23957,12 @@ "Arachidonic Acid (20:4,w6)", "Wikidata:Q407699", "ChEBI:15843", - "ChEBI:15843", - "InChI:YZXBAPSDXZZRGB-DOFZRALJSA-N" + "InChI:YZXBAPSDXZZRGB-DOFZRALJSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -24089,8 +24370,12 @@ "2,3 dinor-6-keto-PGF1α", "Wikidata:Q27144266", "ChEBI:73944", - "ChEBI:73944", - "InChI:DNKGWNLXBRCUCF-NLOSNHEGSA-N" + "InChI:DNKGWNLXBRCUCF-NLOSNHEGSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -24410,8 +24695,12 @@ "6-keto-PGF1α", "Wikidata:Q27103534", "ChEBI:28158", - "ChEBI:28158", - "InChI:KFGOFTHODYBSGM-ZUNNJUQCSA-N" + "InChI:KFGOFTHODYBSGM-ZUNNJUQCSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -24826,8 +25115,10 @@ "DH-15d-Δ12,14-PGD2", "Wikidata:Q76507195", "ChEBI:165317", - "ChEBI:165317", - "InChI:FGAVXMGIBNHPKY-PMRZYBNXSA-N" + "InChI:FGAVXMGIBNHPKY-PMRZYBNXSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -24992,8 +25283,11 @@ "5(S),6(S)-epoxy-15(S)-HETE", "Wikidata:Q27133027", "ChEBI:64095", - "ChEBI:64095", - "InChI:YNHSGCYEQVDEOY-UZDWIPAXSA-N" + "InChI:YNHSGCYEQVDEOY-UZDWIPAXSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -25039,8 +25333,11 @@ "13,14-dihydro-15-keto-PGA2", "Wikidata:Q27161501", "ChEBI:89315", - "ChEBI:89315", - "InChI:FMKLAIBZMCURLI-BFVRRIQPSA-N" + "InChI:FMKLAIBZMCURLI-BFVRRIQPSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -25183,8 +25480,11 @@ "Ca2+", "Wikidata:Q23905776", "ChEBI:29108", - "ChEBI:29108", - "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N" + "InChI:BHPQYMZQTOCNFJ-UHFFFAOYSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -25225,8 +25525,12 @@ "LTD4", "Wikidata:Q647917", "ChEBI:28666", - "ChEBI:28666", - "InChI:YEESKJGWJFYOOK-IJHYULJSSA-N" + "InChI:YEESKJGWJFYOOK-IJHYULJSSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -26031,8 +26335,11 @@ "15-keto-13,14-dihydro-PGF2α", "Wikidata:Q27070766", "ChEBI:63976", - "ChEBI:63976", - "InChI:VKTIONYPMSCHQI-XAGFEHLVSA-N" + "InChI:VKTIONYPMSCHQI-XAGFEHLVSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -26182,8 +26489,12 @@ "LXA4", "Wikidata:Q27082450", "ChEBI:6498", - "ChEBI:6498", - "InChI:IXAQOQZEOGMIQS-SSQFXEBMSA-N" + "InChI:IXAQOQZEOGMIQS-SSQFXEBMSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -26344,9 +26655,15 @@ "11-dehydro-TxB2", "Wikidata:Q2806929", "ChEBI:28667", - "ChEBI:28667", "InChI:KJYIVXDPWBUJBQ-SOGWKEBJSA-N", - "InChI:KJYIVXDPWBUJBQ-UHHGALCXSA-N" + "InChI:KJYIVXDPWBUJBQ-UHHGALCXSA-N", + "", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -26531,8 +26848,12 @@ "LTE4", "Wikidata:Q2705859", "ChEBI:15650", - "ChEBI:15650", - "InChI:OTZRAYGBFWZKMX-FRFVZSDQSA-N" + "InChI:OTZRAYGBFWZKMX-FRFVZSDQSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -26780,8 +27101,12 @@ "6-keto-PGE1", "Wikidata:Q27103600", "ChEBI:28269", - "ChEBI:28269", - "InChI:ROUDCKODIMKLNO-CTBSXBMHSA-N" + "InChI:ROUDCKODIMKLNO-CTBSXBMHSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -26822,8 +27147,12 @@ "PGE2", "Wikidata:Q416554", "ChEBI:15551", - "ChEBI:15551", - "InChI:XEYBRNLFEZDVAW-ARSRFYASSA-N" + "InChI:XEYBRNLFEZDVAW-ARSRFYASSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -26926,8 +27255,12 @@ "Osbond acid (22:5,w6)", "Wikidata:Q3278345", "ChEBI:53488", - "ChEBI:53488", - "InChI:YUFFSWGQGVEMMI-JLNKQSITSA-N" + "InChI:YUFFSWGQGVEMMI-JLNKQSITSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -27061,8 +27394,10 @@ "CompactIdentifier:hmdb:HMDB0006246", "Tetracosatetraenoic acid (24:4, w-6)", "ChEBI:77526", - "ChEBI:77526", - "InChI:MMJZTSLHOIGZPU-DOFZRALJSA-N" + "InChI:MMJZTSLHOIGZPU-DOFZRALJSA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -28069,7 +28404,11 @@ "CompactIdentifier:pubchem.compound:53481508", "20-COOH-LTE4", "Wikidata:Q76727511", - "InChI:HVLRBLGTGJGVCX-RHSCJZQUSA-N" + "InChI:HVLRBLGTGJGVCX-RHSCJZQUSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -28111,8 +28450,11 @@ "IP3", "Wikidata:Q26998374", "ChEBI:16595", - "ChEBI:16595", - "InChI:MMWCIQZXVOZEGG-XJTPDSDZSA-N" + "InChI:MMWCIQZXVOZEGG-XJTPDSDZSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -28340,9 +28682,13 @@ "6,15-Diketo-13,14-dihydro-PGF1α", "Wikidata:Q27140003", "ChEBI:72595", - "ChEBI:72595", "InChI:VGCSSPQIZFVVCH-UVBCEDGCSA-N", - "InChI:VKPWUQVGTPVEMU-QVPQFPIISA-N" + "InChI:VKPWUQVGTPVEMU-QVPQFPIISA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -28521,8 +28867,12 @@ "PGD2", "Wikidata:Q419750", "ChEBI:15555", - "ChEBI:15555", - "InChI:BHMBVRSPMRCCGG-OUTUXVNYSA-N" + "InChI:BHMBVRSPMRCCGG-OUTUXVNYSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -28563,8 +28913,11 @@ "PGH1", "Wikidata:Q27163072", "ChEBI:91133", - "ChEBI:91133", - "InChI:NTAYABHEVAQSJS-CDIPTNKSSA-N" + "InChI:NTAYABHEVAQSJS-CDIPTNKSSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -28728,8 +29081,12 @@ "PGJ2", "Wikidata:Q27088353", "ChEBI:27485", - "ChEBI:27485", - "InChI:UQOQENZZLBSFKO-POPPZSFYSA-N" + "InChI:UQOQENZZLBSFKO-POPPZSFYSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -28773,8 +29130,12 @@ "15-keto-PGE1", "Wikidata:Q27098096", "ChEBI:15548", - "ChEBI:15548", - "InChI:VXPBDCBTMSKCKZ-XQHNHVHJSA-N" + "InChI:VXPBDCBTMSKCKZ-XQHNHVHJSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -28906,8 +29267,12 @@ "PGD1", "Wikidata:Q27103269", "ChEBI:27696", - "ChEBI:27696", - "InChI:CIMMACURCPXICP-PNQRDDRVSA-N" + "InChI:CIMMACURCPXICP-PNQRDDRVSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -29228,9 +29593,14 @@ "PGB2", "Wikidata:Q27093323", "ChEBI:28099", - "ChEBI:28099", "InChI:PRFXRIUZNKLRHM-HKVRTXJWSA-N", - "InChI:PRFXRIUZNKLRHM-RYPCXPIFSA-N" + "InChI:PRFXRIUZNKLRHM-RYPCXPIFSA-N", + "", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -29370,8 +29740,12 @@ "TxA", "Wikidata:Q774909", "ChEBI:15627", - "ChEBI:15627", - "InChI:DSNBHJFQCNUKMA-SCKDECHMSA-N" + "InChI:DSNBHJFQCNUKMA-SCKDECHMSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -30125,8 +30499,12 @@ "PGG2", "Wikidata:Q19835971", "ChEBI:27647", - "ChEBI:27647", - "InChI:SGUKUZOVHSFKPH-YNNPMVKQSA-N" + "InChI:SGUKUZOVHSFKPH-YNNPMVKQSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -30521,8 +30899,11 @@ "Δ6-trans-12-epi-LTB4", "Wikidata:Q27132948", "ChEBI:63982", - "ChEBI:63982", - "InChI:VNYSSYRCGWBHLG-CTOJTRLNSA-N" + "InChI:VNYSSYRCGWBHLG-CTOJTRLNSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -31291,8 +31672,10 @@ "19-OH-PGE2", "Wikidata:Q27070797", "ChEBI:165313", - "ChEBI:165313", - "InChI:WTJYDBMHYPQFNJ-ZUVVJKHESA-N" + "InChI:WTJYDBMHYPQFNJ-ZUVVJKHESA-N", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -31363,8 +31746,12 @@ "15-deoxy-Δ12,14-PGJ2", "Wikidata:Q27070775", "ChEBI:34159", - "ChEBI:34159", - "InChI:VHRUMKCAEVRUBK-GODQJPCRSA-N" + "InChI:VHRUMKCAEVRUBK-GODQJPCRSA-N", + "", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -31796,8 +32183,11 @@ "15-deoxy-Δ12,14-PGD2", "Wikidata:Q27132957", "ChEBI:63999", - "ChEBI:63999", - "InChI:WPAYHTRLEHKDHP-UBEAGDKLSA-N" + "InChI:WPAYHTRLEHKDHP-UBEAGDKLSA-N", + "", + "", + "", + "" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -34738,9 +35128,6 @@ "comments": [ { "content": "Reference: https://doi.org/10.1016/0165-6147(86)90312-3" - }, - { - "content": "Type your comment here" } ], "drawAs": "StraightLine", @@ -50251,9 +50638,6 @@ "comments": [ { "content": "Enzyme is omega-oxidase: CYP4F3. There are two isoforms CYP4F3A and CYP4F3B. CYP4F3A has a higher affinity to catalyze this reaction." - }, - { - "content": "Type your comment here" } ], "drawAs": "StraightLine", @@ -52685,7 +53069,7 @@ "id": "publicationXrefa02", "source": "J Biol Chem", "standardName": "Metabolism of prostacyclin by 9-hydroxyprostaglandin dehydrogenase in human platelets. Formation of a potent inhibitor of platelet aggregation and enzyme purification.", - "textContent": "9", + "textContent": "5", "type": [ "PublicationXref", "PubMed:6997309" @@ -52704,7 +53088,7 @@ "id": "publicationXrefa09", "source": "PubMed", "standardName": "Membrane prostaglandin E synthase -1: a novel therapeutic target", - "textContent": "81", + "textContent": "114", "type": [ "PublicationXref", "PubMed:17878511" @@ -52725,7 +53109,7 @@ "id": "publicationXrefa0a", "source": "Mediators Inflamm", "standardName": "Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related Diseases.", - "textContent": "138", + "textContent": "69", "type": [ "PublicationXref", "PubMed:29674943" @@ -52744,7 +53128,7 @@ "id": "publicationXrefa2a", "source": "Prostaglandins Other Lipid Mediat", "standardName": "Formation of lipoxins and resolvins in human leukocytes.", - "textContent": "186", + "textContent": "93", "type": [ "PublicationXref", "PubMed:36878381" @@ -52768,7 +53152,7 @@ "id": "publicationXrefa40", "source": "Prostaglandins", "standardName": "Measurements of urinary prostaglandins in young ovulatory women during the menstrual cycle and in postmenopausal women.", - "textContent": "41", + "textContent": "104", "type": [ "PublicationXref", "PubMed:9373880" @@ -52789,7 +53173,7 @@ "id": "publicationXrefa4d", "source": "Int J Mol Sci", "standardName": "Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways.", - "textContent": "175", + "textContent": "186", "type": [ "PublicationXref", "PubMed:37686088" @@ -52813,7 +53197,7 @@ "id": "publicationXrefa4e", "source": "J Biochem", "standardName": "Purification and characterization of human microsomal dipeptidase.", - "textContent": "26", + "textContent": "10", "type": [ "PublicationXref", "PubMed:2768222" @@ -52832,7 +53216,7 @@ "id": "publicationXrefa67", "source": "The Journal of Trauma and Acute Care Surgery", "standardName": "Prostaglandin E2 Synthesis and Metabolism in Burn Injury and Trauma.", - "textContent": "49", + "textContent": "23", "type": [ "PublicationXref" ], @@ -52851,7 +53235,7 @@ "id": "publicationXrefa6d", "source": "EMBO J", "standardName": "5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation.", - "textContent": "65", + "textContent": "161", "type": [ "PublicationXref", "PubMed:15616590" @@ -52870,7 +53254,7 @@ "id": "publicationXrefa6f", "source": "Sci Rep", "standardName": "Novel n-3 immunoresolvents: structures and actions.", - "textContent": "106", + "textContent": "55", "type": [ "PublicationXref", "PubMed:23736886" @@ -52888,7 +53272,7 @@ "id": "publicationXrefa76", "source": "Kidney Int", "standardName": "Formation and metabolism of prostaglandins in the kidney.", - "textContent": "13", + "textContent": "97", "type": [ "PublicationXref", "PubMed:6790808" @@ -52908,7 +53292,7 @@ "id": "publicationXrefa7c", "source": "Int J Mol Sci", "standardName": "Lipid Mediators Regulate Pulmonary Fibrosis: Potential Mechanisms and Signaling Pathways.", - "textContent": "149", + "textContent": "176", "type": [ "PublicationXref", "PubMed:32549377" @@ -52936,7 +53320,7 @@ "id": "publicationXrefa82", "source": "Biochim Biophys Acta Mol Cell Biol Lipids", "standardName": "On the biosynthesis of specialized pro-resolvingmediators in human neutrophils and the influence of cell integrity.", - "textContent": "173", + "textContent": "90", "type": [ "PublicationXref", "PubMed:34942381" @@ -52956,7 +53340,7 @@ "id": "publicationXrefa86", "source": "J Physiol Pharmacol", "standardName": "On the metabolism of prostaglandin E1 administered intravenously to human volunteers.", - "textContent": "29", + "textContent": "13", "type": [ "PublicationXref", "PubMed:1793892" @@ -52976,7 +53360,7 @@ "id": "publicationXrefa8e", "source": "J Biol Chem", "standardName": "Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.", - "textContent": "6", + "textContent": "3", "type": [ "PublicationXref", "PubMed:104998" @@ -52993,7 +53377,7 @@ "id": "publicationXrefa9d", "source": "Chem Phys Lipids", "standardName": "Distinguishing levuglandins produced through the cyclooxygenase and isoprostane pathways.", - "textContent": "66", + "textContent": "33", "type": [ "PublicationXref", "PubMed:15752459" @@ -53016,7 +53400,7 @@ "id": "publicationXrefadb", "source": "J Biol Chem", "standardName": "p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2.", - "textContent": "37", + "textContent": "153", "type": [ "PublicationXref", "PubMed:8910365" @@ -53035,7 +53419,7 @@ "id": "publicationXrefadc", "source": "Brain Pathol", "standardName": "The biochemistry of the isoprostane, neuroprostane, and isofuran Pathways of lipid peroxidation.", - "textContent": "73", + "textContent": "159", "type": [ "PublicationXref", "PubMed:15912887" @@ -53056,7 +53440,7 @@ "id": "publicationXrefae8", "source": "Prostaglandins Other Lipid Mediat", "standardName": "Effects of prostaglandin E1 metabolites on the induction of arterial thromboresistance.", - "textContent": "43", + "textContent": "22", "type": [ "PublicationXref", "PubMed:9653766" @@ -53081,7 +53465,7 @@ "id": "publicationXrefaec", "source": "Plant Methods", "standardName": "Rapid expression of transgenes driven by seed-specific constructs in leaf tissue: DHA production.", - "textContent": "92", + "textContent": "44", "type": [ "PublicationXref", "PubMed:20222981" @@ -53099,7 +53483,7 @@ "id": "publicationXrefaf7", "source": "Nutrients", "standardName": "Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021.", - "textContent": "159", + "textContent": "134", "type": [ "PublicationXref", "PubMed:34371930" @@ -53124,7 +53508,7 @@ "id": "publicationXrefaf8", "source": "Exp Cell Res", "standardName": "Normal or stress-induced fibroblast senescence involves COX-2 activity.", - "textContent": "82", + "textContent": "37", "type": [ "PublicationXref", "PubMed:17560572" @@ -53142,7 +53526,7 @@ "id": "publicationXrefaf9", "source": "J Clin Invest", "standardName": "Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators.", - "textContent": "134", + "textContent": "68", "type": [ "PublicationXref", "PubMed:29757195" @@ -53165,7 +53549,7 @@ "id": "publicationXrefb09", "source": "Biochemistry", "standardName": "5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1.", - "textContent": "137", + "textContent": "126", "type": [ "PublicationXref", "PubMed:30407793" @@ -53190,7 +53574,7 @@ "id": "publicationXrefb17", "source": "Annu Rev Nutr", "standardName": "FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health.", - "textContent": "142", + "textContent": "73", "type": [ "PublicationXref", "PubMed:31433740" @@ -53221,7 +53605,7 @@ "id": "publicationXrefb2f", "source": "ScienceDirect", "standardName": "PRAK Is Essential for ras-Induced Senescence and Tumor Suppression", - "textContent": "79", + "textContent": "41", "type": [ "PublicationXref", "PubMed:17254968" @@ -53239,7 +53623,7 @@ "id": "publicationXrefb39", "source": "Prostaglandins Leukot Essent Fatty Acids", "standardName": "Determination of 9alpha, 11beta prostaglandin F2 in human urine. combination of solid-phase extraction and radioimmunoassay.", - "textContent": "54", + "textContent": "108", "type": [ "PublicationXref", "PubMed:11993720" @@ -53257,7 +53641,7 @@ "id": "publicationXrefb4b", "source": "J Biomed Biotechnol", "standardName": "5-Lipoxygenase Pathway, Dendritic Cells, and Adaptive Immunity.", - "textContent": "64", + "textContent": "29", "type": [ "PublicationXref", "PubMed:15240920" @@ -53275,7 +53659,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefb4d", "standardName": "Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration", - "textContent": "123", + "textContent": "63", "type": [ "PublicationXref", "PubMed:26748744" @@ -53293,7 +53677,7 @@ "id": "publicationXrefb57", "source": "Front Cell Dev Biol", "standardName": "Fibroblast Senescence in Idiopathic Pulmonary Fibrosis.", - "textContent": "151", + "textContent": "78", "type": [ "PublicationXref", "PubMed:33324646" @@ -53314,7 +53698,7 @@ "id": "publicationXrefb5d", "source": "Eur Rev Med Pharmacol Sci", "standardName": "Maresins: anti-inflammatory pro-resolving mediators with therapeutic potential.", - "textContent": "157", + "textContent": "129", "type": [ "PublicationXref", "PubMed:32706084" @@ -53338,7 +53722,7 @@ "id": "publicationXrefb5e", "source": "Prog Lipid Res", "standardName": "Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25years of research in chemistry and biology.", - "textContent": "128", + "textContent": "124", "type": [ "PublicationXref", "PubMed:28923590" @@ -53368,7 +53752,7 @@ "id": "publicationXrefb68", "source": "JCI Insight", "standardName": "Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis.", - "textContent": "140", + "textContent": "128", "type": [ "PublicationXref", "PubMed:31687975" @@ -53390,7 +53774,7 @@ "id": "publicationXrefb78", "source": "British Journal of Dermatology", "standardName": "In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis.", - "textContent": "40", + "textContent": "18", "type": [ "PublicationXref", "PubMed:9115911" @@ -53411,7 +53795,7 @@ "id": "publicationXrefb7a", "source": "Front Endocrinol (Lausanne)", "standardName": "The Biosynthesis of Enzymatically Oxidized Lipids.", - "textContent": "145", + "textContent": "130", "type": [ "PublicationXref", "PubMed:33329396" @@ -53430,7 +53814,7 @@ "id": "publicationXrefb7c", "source": "Biochim Biophys Acta", "standardName": "The isoprostanes--25 years later.", - "textContent": "114", + "textContent": "60", "type": [ "PublicationXref", "PubMed:25449649" @@ -53448,7 +53832,7 @@ "id": "publicationXrefb8d", "source": "Pharmacol Rev", "standardName": "Endogenous glutathione conjugates: occurrence and biological functions.", - "textContent": "46", + "textContent": "19", "type": [ "PublicationXref", "PubMed:9755286" @@ -53467,7 +53851,7 @@ "id": "publicationXrefb90", "source": "https://journals.lww.com/jtrauma/Fulltext/2000/12000/Prostaglandin_E2_Synthesis_and_Metabolism_in_Burn.33.aspx", "standardName": "Prostaglandin E2 Synthesis and Metabolism in Burn Injury and Trauma", - "textContent": "179", + "textContent": "94", "type": [ "PublicationXref" ], @@ -53486,7 +53870,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefbab", "standardName": "Identification of a Novel Prostaglandin Reductase Reveals the Involvement of Prostaglandin E2 Catabolism in Regulation of Peroxisome Proliferator-activated Receptor γ Activation", - "textContent": "86", + "textContent": "166", "type": [ "PublicationXref", "PubMed:17449869" @@ -53505,7 +53889,7 @@ "id": "publicationXrefbaf", "source": "Methods Enzymol", "standardName": "Radioimmunologic determination of 15-keto-13,14-dihydro-PGE2: a method for its stable degradation product, 11-deoxy-15-keto-13,14-dihydro-11 beta, 16 xi-cyclo-PGE2.", - "textContent": "14", + "textContent": "99", "type": [ "PublicationXref", "PubMed:7132761" @@ -53540,7 +53924,7 @@ "id": "publicationXrefbc3", "source": "PPAR Res", "standardName": "15-Deoxy-∆-(12,14)-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism.", - "textContent": "139", + "textContent": "74", "type": [ "PublicationXref", "PubMed:31467514" @@ -53560,7 +53944,7 @@ "id": "publicationXrefbcc", "source": "Prostaglandins", "standardName": "Identification of 11-dehydro-TXB2 as a suitable parameter for monitoring thromboxane production in the human.", - "textContent": "24", + "textContent": "149", "type": [ "PublicationXref", "PubMed:3755250" @@ -53578,7 +53962,7 @@ "id": "publicationXrefbd0", "source": "Tetrahedron Lett", "standardName": "First total syntheses of the pro-resolving lipid mediators 7(S),13(R),20(S)-Resolvin T1 and 7(S),13(R)-Resolvin T4.", - "textContent": "147", + "textContent": "180", "type": [ "PublicationXref", "PubMed:32313313" @@ -53599,7 +53983,7 @@ "id": "publicationXrefbd2", "source": "Eur Rev Med Pharmacol Sci", "standardName": "Maresins: anti-inflammatory pro-resolving mediators with therapeutic potential.", - "textContent": "156", + "textContent": "178", "type": [ "PublicationXref", "PubMed:32706084" @@ -53620,7 +54004,7 @@ "id": "publicationXrefbd5", "source": "Prostaglandins Other Lipid Mediat", "standardName": "On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens.", - "textContent": "68", + "textContent": "111", "type": [ "PublicationXref", "PubMed:15789615" @@ -53644,7 +54028,7 @@ "id": "publicationXrefbda", "source": "J Chromatogr B Analyt Technol Biomed Life Sci", "standardName": "Quantification of F-ring isoprostane-like compounds (F4-neuroprostanes) derived from docosahexaenoic acid in vivo in humans by a stable isotope dilution mass spectrometric assay.", - "textContent": "60", + "textContent": "31", "type": [ "PublicationXref", "PubMed:14659440" @@ -53661,7 +54045,7 @@ "id": "publicationXrefbee", "source": "Mol Biol Rep", "standardName": "The enzymology of human eicosanoid pathways: the lipoxygenase branches.", - "textContent": "155", + "textContent": "132", "type": [ "PublicationXref", "PubMed:32748021" @@ -53680,7 +54064,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefbf1", "standardName": "Metabolism of prostacyclin and 6-keto-prostaglandin F1 alpha in man", - "textContent": "11", + "textContent": "145", "type": [ "PublicationXref", "PubMed:7000774" @@ -53703,7 +54087,7 @@ "id": "publicationXrefbf3", "source": "Mech Ageing Dev", "standardName": "The ATF6Ă�ƒÆ’Ă�†â€™Ă�ƒâ€¦Ă�‚½Ă�ƒÆ’Ă�¢â‚¬Å¡Ă�ƒâ€šĂ�‚± arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2intracrine pathway.", - "textContent": "133", + "textContent": "72", "type": [ "PublicationXref", "PubMed:28803844" @@ -53724,7 +54108,7 @@ "id": "publicationXrefc02", "source": "Chem Rev", "standardName": "Isoprostane generation and function.", - "textContent": "96", + "textContent": "51", "type": [ "PublicationXref", "PubMed:21848345" @@ -53747,7 +54131,7 @@ "id": "publicationXrefc06", "source": "Biochem Biophys Res Commun", "standardName": "Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia.", - "textContent": "108", + "textContent": "53", "type": [ "PublicationXref", "PubMed:23743193" @@ -53767,7 +54151,7 @@ "id": "publicationXrefc1c", "source": "Journal of Biological Chemistry", "standardName": "Metabolism of prostacyclin and 6-keto-prostaglandin F1 alpha in man.", - "textContent": "8", + "textContent": "95", "type": [ "PublicationXref" ], @@ -53790,7 +54174,7 @@ "id": "publicationXrefc1f", "source": "Proc Natl Acad Sci U S A", "standardName": "Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells.", - "textContent": "87", + "textContent": "116", "type": [ "PublicationXref", "PubMed:18184802" @@ -53808,7 +54192,7 @@ "id": "publicationXrefc22", "source": "Life Sciences", "standardName": "Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance - A review", - "textContent": "132", + "textContent": "70", "type": [ "PublicationXref" ], @@ -53824,7 +54208,7 @@ "id": "publicationXrefc30", "source": "National Library of Medicine", "standardName": "Review: 6 keto-prostaglandin-E1", - "textContent": "20", + "textContent": "147", "type": [ "PublicationXref", "PubMed:6361908" @@ -53842,7 +54226,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefc3a", "standardName": "Effect of Prostanoids on Human Platelet Function: An Overview", - "textContent": "144", + "textContent": "77", "type": [ "PublicationXref", "PubMed:33260972" @@ -53867,7 +54251,7 @@ "id": "publicationXrefc3d", "source": "J Biol Chem", "standardName": "Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans.", - "textContent": "89", + "textContent": "42", "type": [ "PublicationXref", "PubMed:17993463" @@ -53884,7 +54268,7 @@ "id": "publicationXrefc42", "source": "J Cell Commun Signal", "standardName": "A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action.", - "textContent": "184", + "textContent": "135", "type": [ "PublicationXref", "PubMed:34173964" @@ -53903,7 +54287,7 @@ "id": "publicationXrefc47", "source": "Cancer Lett", "standardName": "Prostaglandin E3 metabolism and cancer.", - "textContent": "110", + "textContent": "56", "type": [ "PublicationXref", "PubMed:24657656" @@ -53928,7 +54312,7 @@ "id": "publicationXrefc4b", "source": "Prostaglandins Leukot Essent Fatty Acids", "standardName": "Effect of dietary calcium on renal prostaglandins.", - "textContent": "30", + "textContent": "11", "type": [ "PublicationXref", "PubMed:1857725" @@ -53945,7 +54329,7 @@ "id": "publicationXrefc4e", "source": "Hormones :171-188", "standardName": "Eicosanoids", - "textContent": "118", + "textContent": "119", "type": [ "PublicationXref" ], @@ -53967,7 +54351,7 @@ "id": "publicationXrefc5c", "source": "Prog Lipid Res", "standardName": "Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25years of researchin chemistry and biology.", - "textContent": "126", + "textContent": "65", "type": [ "PublicationXref", "PubMed:28923590" @@ -53987,7 +54371,7 @@ "id": "publicationXrefc62", "source": "Molecules", "standardName": "Resolvins, Protectins, and Maresins: DHA-Derived Specialized Pro-Resolving Mediators, Biosynthetic Pathways, Synthetic Approaches, and Their Role in Inflammation.", - "textContent": "170", + "textContent": "91", "type": [ "PublicationXref", "PubMed:35268778" @@ -54011,7 +54395,7 @@ "id": "publicationXrefc74", "source": "Biochemistry", "standardName": "Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid.", - "textContent": "52", + "textContent": "24", "type": [ "PublicationXref", "PubMed:10694406" @@ -54029,7 +54413,7 @@ "id": "publicationXrefc7a", "source": "Pubmed", "standardName": "Dihomo-γ-Linolenic Acid (20:3n-6)—Metabolism, Derivatives, and Potential Significance in Chronic Inflammation", - "textContent": "176", + "textContent": "187", "type": [ "PublicationXref", "PubMed:36768438" @@ -54051,7 +54435,7 @@ "id": "publicationXrefc7f", "source": "Cell Metabolism", "standardName": "Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.", - "textContent": "168", + "textContent": "182", "type": [ "PublicationXref" ], @@ -54069,7 +54453,7 @@ "id": "publicationXrefc85", "source": "Biochem Biophys Res Commun", "standardName": "Urinary 8-epi-PGF2alpha and its endogenous beta-oxidation products (2,3-dinor and 2,3-dinor-5,6-dihydro) as biomarkers of total body oxidative stress.", - "textContent": "71", + "textContent": "34", "type": [ "PublicationXref", "PubMed:15809058" @@ -54088,7 +54472,7 @@ "id": "publicationXrefc8a", "source": "Lipids in Health and Disease", "standardName": "Multiple roles of dihomo-y-linolenic acid against proliferation diseases", - "textContent": "104", + "textContent": "169", "type": [ "PublicationXref", "PubMed:22333072" @@ -54117,7 +54501,7 @@ "id": "publicationXrefc8d", "source": "Food Funct", "standardName": "Effect of the dietary intake of melatonin- and hydroxytyrosol-rich wines by healthy female volunteers on the systemic lipidomic-related oxylipins.", - "textContent": "125", + "textContent": "122", "type": [ "PublicationXref", "PubMed:28956582" @@ -54134,7 +54518,7 @@ "id": "publicationXrefc94", "source": "Medicinal Research Reviews", "standardName": "Novel cyclooxygenase-catalyzed bioactive prostaglandin F2alpha from physiology to new principles in inflammation.", - "textContent": "80", + "textContent": "40", "type": [ "PublicationXref", "PubMed:17191216" @@ -54153,7 +54537,7 @@ "id": "publicationXrefc95", "source": "Clin Immunol", "standardName": "Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases.", - "textContent": "76", + "textContent": "36", "type": [ "PublicationXref", "PubMed:16540375" @@ -54172,7 +54556,7 @@ "id": "publicationXrefc9d", "source": "Trends Cell Biol", "standardName": "Hallmarks of Cellular Senescence.", - "textContent": "130", + "textContent": "125", "type": [ "PublicationXref", "PubMed:29477613" @@ -54190,7 +54574,7 @@ "id": "publicationXrefcad", "source": "Front Pharmacol", "standardName": "The Functions of Cytochrome P450 ω-hydroxylases and the Associated Eicosanoids in Inflammation-Related Diseases.", - "textContent": "160", + "textContent": "86", "type": [ "PublicationXref", "PubMed:34594219" @@ -54207,7 +54591,7 @@ "id": "publicationXrefcae", "source": "Medicinal Research Reviews", "standardName": "Novel cyclooxygenase-catalyzed bioactive prostaglandin F2a from physiology to new principles in inflammation.", - "textContent": "75", + "textContent": "162", "type": [ "PublicationXref" ], @@ -54224,7 +54608,7 @@ "id": "publicationXrefcb8", "source": "The Journal of Clinical Endocinology & Metabolism", "standardName": "Prostaglandin E2 Regulates Its Own Inactivating Enzyme, 15-PGHD, by EP2 Receptor-Mediated Cervical Cell-Specific Mechanisms", - "textContent": "109", + "textContent": "57", "type": [ "PublicationXref", "PubMed:24471568" @@ -54243,7 +54627,7 @@ "id": "publicationXrefcca", "source": "Trends Biochem Sci", "standardName": "Polyunsaturated fatty acid synthesis: what will they think of next?", - "textContent": "57", + "textContent": "157", "type": [ "PublicationXref", "PubMed:12217522" @@ -54269,7 +54653,7 @@ "id": "publicationXrefcdb", "source": "Prostaglandins Other Lipid Mediat", "standardName": "Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes.", - "textContent": "72", + "textContent": "158", "type": [ "PublicationXref", "PubMed:15789622" @@ -54292,7 +54676,7 @@ "id": "publicationXrefcdc", "source": "Journal of Biological Chemistry", "standardName": "Identification of a Novel Prostaglandin Reductase Reveals the Involvement of Prostaglandin E2 Catabolism in Regulation of Peroxisome Proliferator-activated Receptor γ Activation.", - "textContent": "85", + "textContent": "39", "type": [ "PublicationXref" ], @@ -54309,7 +54693,7 @@ "id": "publicationXrefce1", "source": "American Physiological Society Journal", "standardName": "Prostaglandin B2-induced pulmonary hypertension is mediated by TxA2/PGH2 receptor stimulation", - "textContent": "34", + "textContent": "102", "type": [ "PublicationXref", "PubMed:7977770" @@ -54327,7 +54711,7 @@ "id": "publicationXrefce2", "source": "Essays Biochem", "standardName": "Specialized pro-resolving mediator network: an update on production and actions.", - "textContent": "152", + "textContent": "133", "type": [ "PublicationXref", "PubMed:32885825" @@ -54375,7 +54759,7 @@ "id": "publicationXrefcee", "source": "Chem Res Toxicol", "standardName": "Levuglandin E2-protein adducts in human plasma and vasculature.", - "textContent": "42", + "textContent": "106", "type": [ "PublicationXref", "PubMed:9168251" @@ -54393,7 +54777,7 @@ "id": "publicationXrefcf0", "source": "Kidney International", "standardName": "Formation and metabolism of prostaglandins in the kidney.", - "textContent": "12", + "textContent": "96", "type": [ "PublicationXref" ], @@ -54414,7 +54798,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefcfe", "standardName": "Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans", - "textContent": "90", + "textContent": "115", "type": [ "PublicationXref", "PubMed:17993463" @@ -54432,7 +54816,7 @@ "id": "publicationXrefd04", "source": "Chem Rev", "standardName": "Resolvins and protectins in inflammation resolution.", - "textContent": "100", + "textContent": "52", "type": [ "PublicationXref", "PubMed:21766791" @@ -54458,7 +54842,7 @@ "id": "publicationXrefd08", "source": "Microb Pathog", "standardName": "Does leukotriene F4 play a major role in the infection mechanism of Candida sp.?", - "textContent": "143", + "textContent": "177", "type": [ "PublicationXref", "PubMed:32707317" @@ -54480,7 +54864,7 @@ "id": "publicationXrefd16", "source": "Am J Physiol Heart Circ Physiol", "standardName": "Metabolism of adrenic acid to vasodilatory 1alpha,1beta-dihomo-epoxyeicosatrienoic acids by bovine coronary arteries.", - "textContent": "84", + "textContent": "165", "type": [ "PublicationXref", "PubMed:17209008" @@ -54498,7 +54882,7 @@ "id": "publicationXrefd1f", "source": "British Medical Bulletin", "standardName": "Clinical pharmacology and potential of prostacyclin.", - "textContent": "17", + "textContent": "7", "type": [ "PublicationXref", "PubMed:6354353" @@ -54520,7 +54904,7 @@ "id": "publicationXrefd24", "source": "Biochimie", "standardName": "Isoprostanes and phytoprostanes: Bioactive lipids.", - "textContent": "102", + "textContent": "47", "type": [ "PublicationXref", "PubMed:20594988" @@ -54537,7 +54921,7 @@ "id": "publicationXrefd2c", "source": "Curr Opin Cell Biol", "standardName": "Cyclooxygenases, peroxide tone and the allure of fish oil", - "textContent": "70", + "textContent": "112", "type": [ "PublicationXref", "PubMed:15780594" @@ -54558,7 +54942,7 @@ "id": "publicationXrefd2e", "source": "Chem Rev", "standardName": "Isoprostane generation and function.", - "textContent": "93", + "textContent": "48", "type": [ "PublicationXref", "PubMed:21848345" @@ -54576,7 +54960,7 @@ "id": "publicationXrefd31", "source": "Hormones (Third Edition)", "standardName": "Chapter 8 - Eicosanoids", - "textContent": "112", + "textContent": "61", "type": [ "PublicationXref" ], @@ -54587,7 +54971,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefd3e", "standardName": "Protectins, Resolvins and Maresins - Specialized Pro-Resolving Mediators", - "textContent": "177", + "textContent": "141", "type": [ "PublicationXref" ], @@ -54605,7 +54989,7 @@ "id": "publicationXrefd3f", "source": "Mol Nutr Food Res", "standardName": "Lipidomics of essential fatty acids and oxygenated metabolites.", - "textContent": "107", + "textContent": "54", "type": [ "PublicationXref", "PubMed:23818385" @@ -54623,7 +55007,7 @@ "id": "publicationXrefd41", "source": "National Library of Medicine", "standardName": "Prostaglandin-metabolizing enzymes during pregnancy: characterization of NAD(+)-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omega-hydroxylase", - "textContent": "38", + "textContent": "17", "type": [ "PublicationXref", "PubMed:8740524" @@ -54643,7 +55027,7 @@ "id": "publicationXrefd48", "source": "J Biol Chem", "standardName": "Arachidonate-derived dihomoprostaglandin production observed in endotoxin-stimulated macrophage-like cells.", - "textContent": "83", + "textContent": "38", "type": [ "PublicationXref", "PubMed:17135246" @@ -54662,7 +55046,7 @@ "id": "publicationXrefd4d", "source": "Biochem Biophys Res Commun", "standardName": "Evidence for the formation of F3-isoprostanes during peroxidation of eicosapentaenoic acid.", - "textContent": "39", + "textContent": "105", "type": [ "PublicationXref", "PubMed:9240462" @@ -54681,7 +55065,7 @@ "id": "publicationXrefd4f", "source": "Bioscience Reports", "standardName": "6-Keto prostaglandin F1 alpha production in endothelial-cell cultures in response to normal and diabetic human serum.", - "textContent": "18", + "textContent": "100", "type": [ "PublicationXref", "PubMed:6340753" @@ -54701,7 +55085,7 @@ "id": "publicationXrefd55", "source": "J Biol Chem", "standardName": "Leukotriene E4 elimination and metabolism in normal human subjects.", - "textContent": "28", + "textContent": "152", "type": [ "PublicationXref", "PubMed:2174886" @@ -54722,7 +55106,7 @@ "id": "publicationXrefd5f", "source": "J Biol Chem", "standardName": "Dihomo-prostaglandins and -thromboxane. A prostaglandin family from adrenic acid that may be preferentially synthesized in the kidney.", - "textContent": "16", + "textContent": "146", "type": [ "PublicationXref", "PubMed:6801054" @@ -54743,7 +55127,7 @@ "id": "publicationXrefd64", "source": "Biochim Biophys Acta", "standardName": "Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome.", - "textContent": "115", + "textContent": "173", "type": [ "PublicationXref", "PubMed:25139562" @@ -54761,7 +55145,7 @@ "id": "publicationXrefd68", "source": "Front Pharmacol.", "standardName": "Measurement of Thromboxane Biosynthesis in Health and Disease", - "textContent": "141", + "textContent": "175", "type": [ "PublicationXref", "PubMed:31736753" @@ -54784,7 +55168,7 @@ "id": "publicationXrefd6f", "source": "Front Immunol", "standardName": "A New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution.", - "textContent": "150", + "textContent": "131", "type": [ "PublicationXref", "PubMed:33643307" @@ -54803,7 +55187,7 @@ "id": "publicationXrefd7a", "source": "EMBO J", "standardName": "p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype.", - "textContent": "97", + "textContent": "45", "type": [ "PublicationXref", "PubMed:21399611" @@ -54823,7 +55207,7 @@ "id": "publicationXrefd87", "source": "National Library of Medicine", "standardName": "Identification of 19 (R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist.", - "textContent": "32", + "textContent": "14", "type": [ "PublicationXref", "PubMed:8248550" @@ -54842,7 +55226,7 @@ "id": "publicationXrefd8d", "source": "Molecules", "standardName": "Generation and detection of levuglandins and isolevuglandins in vitro and in vivo.", - "textContent": "101", + "textContent": "49", "type": [ "PublicationXref", "PubMed:21705973" @@ -54860,7 +55244,7 @@ "id": "publicationXrefd91", "source": "Biochem Pharmacol", "standardName": "Protectins: Their biosynthesis, metabolism and structure-functions.", - "textContent": "183", + "textContent": "184", "type": [ "PublicationXref", "PubMed:36341938" @@ -54879,7 +55263,7 @@ "id": "publicationXrefd95", "source": "Arthritis Research & Therapy", "standardName": "Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2", - "textContent": "69", + "textContent": "35", "type": [ "PublicationXref", "PubMed:15899061" @@ -54899,7 +55283,7 @@ "id": "publicationXrefd9c", "source": "International Journal of Opthalmology", "standardName": "8-iso-prostaglandin-F2a: a possible trigger or accelerator of diabetic retinopathy.", - "textContent": "122", + "textContent": "64", "type": [ "PublicationXref", "PubMed:26949628" @@ -54917,7 +55301,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefda0", "standardName": "Effect of Prostanoids on Human Platelet Function: An Overview", - "textContent": "148", + "textContent": "75", "type": [ "PublicationXref", "PubMed:7730041" @@ -54941,7 +55325,7 @@ "id": "publicationXrefda2", "source": "Prostaglandins Other Lipid Mediat", "standardName": "Role of arachidonic acid lipoxygenase pathway in Asthma.", - "textContent": "171", + "textContent": "183", "type": [ "PublicationXref", "PubMed:34954219" @@ -54959,7 +55343,7 @@ "id": "publicationXrefda6", "source": "PubMed", "standardName": "Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro", - "textContent": "19", + "textContent": "101", "type": [ "PublicationXref", "PubMed:6578214" @@ -54976,7 +55360,7 @@ "id": "publicationXrefdb1", "source": "Prostaglandins", "standardName": "Eicosanoid nomenclature.", - "textContent": "27", + "textContent": "151", "type": [ "PublicationXref", "PubMed:2748920" @@ -54995,7 +55379,7 @@ "id": "publicationXrefdbe", "source": "Journal of Lipid Mediators and Cell Signalling", "standardName": "Biological actions of delta 12-prostaglandin J2", - "textContent": "35", + "textContent": "16", "type": [ "PublicationXref", "PubMed:8777585" @@ -55015,7 +55399,7 @@ "id": "publicationXrefdc7", "source": "J Biol Chem", "standardName": "Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides.", - "textContent": "51", + "textContent": "107", "type": [ "PublicationXref", "PubMed:10791960" @@ -55032,7 +55416,7 @@ "id": "publicationXrefdca", "source": "Hormones:171-188", "standardName": "Eicosanoids", - "textContent": "117", + "textContent": "58", "type": [ "PublicationXref" ], @@ -55048,7 +55432,7 @@ "id": "publicationXrefdcf", "source": "Journal of Advanced Research", "standardName": "Arachidonic acid: Physiological roles and potential health benefits - A review.", - "textContent": "124", + "textContent": "66", "type": [ "PublicationXref", "PubMed:30034874" @@ -55070,7 +55454,7 @@ "id": "publicationXrefdd8", "source": "National Library of Medicine", "standardName": "Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase.", - "textContent": "23", + "textContent": "9", "type": [ "PublicationXref", "PubMed:3456602" @@ -55090,7 +55474,7 @@ "id": "publicationXrefde1", "source": "Prostaglandins", "standardName": "The stability of 13,14-dihydro-15 keto-PGE2", - "textContent": "10", + "textContent": "6", "type": [ "PublicationXref", "PubMed:7384560" @@ -55109,7 +55493,7 @@ "id": "publicationXrefde5", "source": "National Library of Medicine", "standardName": "Biological actions of delta 12-prostaglandin J2", - "textContent": "36", + "textContent": "103", "type": [ "PublicationXref", "PubMed:8777585" @@ -55128,7 +55512,7 @@ "id": "publicationXrefde9", "source": "Mol Cell Biochem", "standardName": "Metabolism of leukotrienes.", - "textContent": "21", + "textContent": "148", "type": [ "PublicationXref", "PubMed:3001504" @@ -55148,7 +55532,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefdf6", "standardName": "6-Keto PGExi A Possible Metabolite of ProstacyclinHaving Platelet Antiaggregatory Effects", - "textContent": "7", + "textContent": "4", "type": [ "PublicationXref", "PubMed:6995292" @@ -55169,7 +55553,7 @@ "id": "publicationXrefdf8", "source": "J Biol Chem", "standardName": "Regiochemistry of neuroprostanes generated from the peroxidation of docosahexaenoic acid in vitro and in vivo.", - "textContent": "67", + "textContent": "160", "type": [ "PublicationXref", "PubMed:15894799" @@ -55187,7 +55571,7 @@ "id": "publicationXrefdfd", "source": "American Journal of Obstetrics & Gynecology", "standardName": "Prostaglandin E2 metabolism in the human fetal membranes.", - "textContent": "25", + "textContent": "150", "type": [ "PublicationXref", "PubMed:2603915" @@ -55209,7 +55593,7 @@ "id": "publicationXrefe15", "source": "Am J Pathol", "standardName": "Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease.", - "textContent": "53", + "textContent": "25", "type": [ "PublicationXref", "PubMed:11141503" @@ -55227,7 +55611,7 @@ "id": "publicationXrefe16", "source": "J Biol Chem", "standardName": "Metabolism of prostaglandins E, A, and C in serum.", - "textContent": "2", + "textContent": "142", "type": [ "PublicationXref", "PubMed:234423" @@ -55252,7 +55636,7 @@ "id": "publicationXrefe20", "source": "Prostaglandins Other Lipid Mediat", "standardName": "On the biosynthesis of 15-HETE and eoxin C4 by human airway epithelial cells.", - "textContent": "120", + "textContent": "59", "type": [ "PublicationXref", "PubMed:26026713" @@ -55271,7 +55655,7 @@ "id": "publicationXrefe22", "source": "Nat Cell Biol", "standardName": "Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence.", - "textContent": "77", + "textContent": "113", "type": [ "PublicationXref", "PubMed:16862142" @@ -55290,7 +55674,7 @@ "id": "publicationXrefe2b", "source": "Prostaglandins Other Lipid Mediat", "standardName": "The novel lipid mediator PD1(n-3 DPA): An overview of the structural elucidation, synthesis, biosynthesis and bioactions.", - "textContent": "129", + "textContent": "67", "type": [ "PublicationXref", "PubMed:28602942" @@ -55311,7 +55695,7 @@ "id": "publicationXrefe31", "source": "Front Nutr", "standardName": "Key Enzymes in Fatty Acid Synthesis Pathway for Bioactive Lipids Biosynthesis.", - "textContent": "181", + "textContent": "138", "type": [ "PublicationXref", "PubMed:35284441" @@ -55328,7 +55712,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXrefe39", "standardName": "Prostanoid Metabolites as Biomarkers in Human Disease", - "textContent": "182", + "textContent": "137", "type": [ "PublicationXref", "PubMed:36005592" @@ -55347,7 +55731,7 @@ "id": "publicationXrefe3d", "source": "Semin Immunol", "standardName": "E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing SPMs for long COVID-19, human clinical trials, and targeted precision nutrition.", - "textContent": "174", + "textContent": "140", "type": [ "PublicationXref", "PubMed:35227568" @@ -55373,7 +55757,7 @@ "id": "publicationXrefe42", "source": "Science", "standardName": "Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength.", - "textContent": "163", + "textContent": "181", "type": [ "PublicationXref", "PubMed:33303683" @@ -55392,7 +55776,7 @@ "id": "publicationXrefe4b", "source": "PLOS ONE", "standardName": "Prostaglandins in biofluids in pregnancy and labour: A systematic review.", - "textContent": "166", + "textContent": "84", "type": [ "PublicationXref", "PubMed:34793529" @@ -55409,7 +55793,7 @@ "id": "publicationXrefe4c", "source": "Biosci Biotechnol Biochem", "standardName": "15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂ as an electrophilic mediator.", - "textContent": "116", + "textContent": "120", "type": [ "PublicationXref", "PubMed:26011133" @@ -55429,7 +55813,7 @@ "id": "publicationXrefe66", "source": "Prostaglandins Other Lipid Mediat", "standardName": "The role of Resolvin D1 in liver diseases.", - "textContent": "178", + "textContent": "89", "type": [ "PublicationXref", "PubMed:35292355" @@ -55448,7 +55832,7 @@ "id": "publicationXrefe73", "source": "British Journal of Pharmacology", "standardName": "Recirculation of prostacyclin (PGI2) in the dog.", - "textContent": "5", + "textContent": "144", "type": [ "PublicationXref", "PubMed:361136" @@ -55467,7 +55851,7 @@ "id": "publicationXrefe88", "source": "Mol Cell Biochem.", "standardName": "Eicosadienoic acid differently modulates production of pro-inflammatory modulators in murine macrophages", - "textContent": "95", + "textContent": "50", "type": [ "PublicationXref", "PubMed:21688154" @@ -55484,7 +55868,7 @@ "id": "publicationXrefe89", "source": "FEBS Lett", "standardName": "Metabolism of 8-iso-prostaglandin F2alpha.", - "textContent": "45", + "textContent": "21", "type": [ "PublicationXref", "PubMed:9645469" @@ -55506,7 +55890,7 @@ "id": "publicationXrefea0", "source": "J Org Chem", "standardName": "Stereoselective Synthesis and Structural Confirmation of the Specialized Pro-Resolving Mediator Resolvin E4.", - "textContent": "162", + "textContent": "82", "type": [ "PublicationXref", "PubMed:33534565" @@ -55539,7 +55923,7 @@ "id": "publicationXrefea3", "source": "Cell Metab", "standardName": "Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.", - "textContent": "164", + "textContent": "83", "type": [ "PublicationXref", "PubMed:33811820" @@ -55556,7 +55940,7 @@ "id": "publicationXrefeae", "source": "Cell Death Differ", "standardName": "Cell cycle regulation: p53-p21-RB signaling.", - "textContent": "169", + "textContent": "88", "type": [ "PublicationXref", "PubMed:35361964" @@ -55577,7 +55961,7 @@ "id": "publicationXrefeb8", "source": "Sci Rep", "standardName": "A polymorphism in the fatty acid desaturase-2 gene is associated with the arachidonic acid metabolism in pigs.", - "textContent": "135", + "textContent": "127", "type": [ "PublicationXref", "PubMed:30254373" @@ -55600,7 +55984,7 @@ "id": "publicationXrefebf", "source": "PLOS ONE", "standardName": "15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury.", - "textContent": "127", + "textContent": "123", "type": [ "PublicationXref", "PubMed:28423012" @@ -55620,7 +56004,7 @@ "id": "publicationXrefed9", "source": "Molecules", "standardName": "Resolvins, Protectins, and Maresins: DHA-Derived Specialized Pro-Resolving Mediators, Biosynthetic Pathways, Synthetic Approaches, and Their Role in Inflammation.", - "textContent": "185", + "textContent": "136", "type": [ "PublicationXref", "PubMed:35268778" @@ -55640,7 +56024,7 @@ "id": "publicationXrefedf", "source": "J Physiol Pharmacol", "standardName": "On the metabolism of prostaglandin E1 administered intravenously to human volunteers.", - "textContent": "31", + "textContent": "12", "type": [ "PublicationXref", "PubMed:1793892" @@ -55661,7 +56045,7 @@ "id": "publicationXrefee8", "source": "International Pediatric Research Foundation", "standardName": "Impaired Degradation of Prostaglandins and Thromboxane in Zellweger Syndrome", - "textContent": "33", + "textContent": "15", "type": [ "PublicationXref" ], @@ -55676,7 +56060,7 @@ "id": "publicationXrefeec", "source": "Prostaglandins Other Lipid Mediat", "standardName": "Prostaglandin F synthase.", - "textContent": "56", + "textContent": "27", "type": [ "PublicationXref", "PubMed:12432932" @@ -55696,7 +56080,7 @@ "id": "publicationXrefef0", "source": "J Biol Chem", "standardName": "Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.", - "textContent": "3", + "textContent": "2", "type": [ "PublicationXref", "PubMed:816795" @@ -55714,7 +56098,7 @@ "id": "publicationXrefef4", "source": "Biochem J", "standardName": "Biosynthesis and metabolism of leukotrienes.", - "textContent": "78", + "textContent": "164", "type": [ "PublicationXref", "PubMed:17623009" @@ -55742,7 +56126,7 @@ "id": "publicationXrefef6", "source": "Prog Lipid Res", "standardName": "Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions.", - "textContent": "172", + "textContent": "139", "type": [ "PublicationXref", "PubMed:35508275" @@ -55763,7 +56147,7 @@ "id": "publicationXrefef7", "source": "National Library of Medicine", "standardName": "Nonenzymatic free radical-catalyzed generation of 15-deoxy-delta-12,14-prostaglandin J2-like compounds (deoxy-J2-isoprostanes) in vivo", - "textContent": "94", + "textContent": "168", "type": [ "PublicationXref", "PubMed:20944061" @@ -55780,7 +56164,7 @@ "id": "publicationXrefef8", "source": "Postgraduate Medical Journal", "standardName": "Introduction to the biosynthesis and metabolism of prostaglandins.", - "textContent": "4", + "textContent": "143", "type": [ "PublicationXref", "PubMed:413106" @@ -55798,7 +56182,7 @@ "id": "publicationXrefefb", "source": "Br J Pharmacol", "standardName": "Resolvins and protectins: mediating solutions to inflammation.", - "textContent": "91", + "textContent": "43", "type": [ "PublicationXref", "PubMed:19594757" @@ -55821,7 +56205,7 @@ "id": "publicationXrefefe", "source": "Int Immunopharmacol", "standardName": "Leukotriene D4 induces cellular senescence in osteoblasts.", - "textContent": "131", + "textContent": "71", "type": [ "PublicationXref", "PubMed:29587204" @@ -55839,7 +56223,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXreff01", "standardName": "Prostaglandin E2 EP Receptors as Therapeutic Targets in Breast Cancer", - "textContent": "103", + "textContent": "117", "type": [ "PublicationXref", "PubMed:22002714" @@ -55857,7 +56241,7 @@ "id": "publicationXreff0a", "source": "DNA and Cell Biology", "standardName": "Prostaglandin I2 and T regulatory Cell Function: Broader Impacts.", - "textContent": "165", + "textContent": "81", "type": [ "PublicationXref", "PubMed:34265210" @@ -55875,7 +56259,7 @@ "id": "publicationXreff0b", "source": "Life Sci", "standardName": "Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance - A review.", - "textContent": "136", + "textContent": "174", "type": [ "PublicationXref", "PubMed:29715470" @@ -55894,7 +56278,7 @@ "id": "publicationXreff0d", "source": "J Biol Chem", "standardName": "Identification of a novel class of endoperoxides from arachidonate autoxidation.", - "textContent": "62", + "textContent": "32", "type": [ "PublicationXref", "PubMed:14594817" @@ -55913,7 +56297,7 @@ "id": "publicationXreff1b", "source": "J Biol Chem", "standardName": "Human biochemistry of the isoprostane pathway.", - "textContent": "88", + "textContent": "167", "type": [ "PublicationXref", "PubMed:18285331" @@ -55937,7 +56321,7 @@ "id": "publicationXreff23", "source": "Biochim Biophys Acta", "standardName": "Cellular senescence involves an intracrine prostaglandin E2 pathway in human fibroblasts.", - "textContent": "105", + "textContent": "170", "type": [ "PublicationXref", "PubMed:24046862" @@ -55960,7 +56344,7 @@ "id": "publicationXreff38", "source": "Genes Cells", "standardName": "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.", - "textContent": "50", + "textContent": "156", "type": [ "PublicationXref", "PubMed:10672042" @@ -55988,7 +56372,7 @@ "id": "publicationXreff3e", "source": "Cell Rep", "standardName": "COX2 regulates senescence secretome composition and senescence surveillance through PGE(2).", - "textContent": "161", + "textContent": "85", "type": [ "PublicationXref", "PubMed:33730589" @@ -56005,7 +56389,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXreff45", "standardName": "Prostaglandin E2 Synthesis and Metabolism in Burn Injury and Trauma", - "textContent": "48", + "textContent": "155", "type": [ "PublicationXref", "PubMed:11130507" @@ -56023,7 +56407,7 @@ "id": "publicationXreff47", "source": "Curr Opin Clin Nutr Metab Care", "standardName": "New understandings of the pathway of long-chain polyunsaturated fatty acid biosynthesis.", - "textContent": "180", + "textContent": "92", "type": [ "PublicationXref", "PubMed:34937850" @@ -56041,7 +56425,7 @@ "id": "publicationXreff4f", "source": "National Library of Medicine", "standardName": "Transformation of prostaglandin D2 to 9 alpha,11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans.", - "textContent": "22", + "textContent": "8", "type": [ "PublicationXref", "PubMed:3862115" @@ -56060,7 +56444,7 @@ "id": "publicationXreff60", "source": "Prostaglandins Leukot Essent Fatty Acids", "standardName": "Prostaglandin synthases: recent developments and a novel hypothesis.", - "textContent": "61", + "textContent": "28", "type": [ "PublicationXref", "PubMed:14683687" @@ -56083,7 +56467,7 @@ "id": "publicationXreff6e", "source": "PLoS One", "standardName": "Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.", - "textContent": "111", + "textContent": "171", "type": [ "PublicationXref", "PubMed:25036362" @@ -56106,7 +56490,7 @@ "id": "publicationXreff70", "source": "National Library of Medicine", "standardName": "cDNA cloning, expression and characterization of human prostaglandin F synthase", - "textContent": "47", + "textContent": "154", "type": [ "PublicationXref", "PubMed:10622721" @@ -56125,7 +56509,7 @@ "gpmlElementName": "PublicationXref", "id": "publicationXreff77", "standardName": "Prostacyclin production during pregnancy: Comparison of production during normal pregnancy and pregnancy complicated by hypertension", - "textContent": "15", + "textContent": "98", "type": [ "PublicationXref", "PubMed:7039321" @@ -56139,7 +56523,7 @@ "id": "publicationXreff7c", "source": "Wikipedia", "standardName": "PLA2G4A", - "textContent": "187", + "textContent": "185", "type": [ "PublicationXref" ], @@ -56158,7 +56542,7 @@ "id": "publicationXreff8b", "source": "Pharmacogenet Genomics", "standardName": "Functional analysis of human thromboxane synthase polymorphic variants", - "textContent": "119", + "textContent": "62", "type": [ "PublicationXref", "PubMed:22735388" @@ -56179,7 +56563,7 @@ "id": "publicationXreff9f", "source": "J Biol Chem", "standardName": "Formation of F-ring isoprostane-like compounds (F3-isoprostanes) in vivo from eicosapentaenoic acid.", - "textContent": "74", + "textContent": "163", "type": [ "PublicationXref", "PubMed:16569632" @@ -56203,7 +56587,7 @@ "id": "publicationXreffa7", "source": "Essays Biochem", "standardName": "Moving forward with isoprostanes, neuroprostanes and phytoprostanes: where are we now?", - "textContent": "154", + "textContent": "76", "type": [ "PublicationXref", "PubMed:32602531" @@ -56223,7 +56607,7 @@ "id": "publicationXreffb0", "source": "FASEB J", "standardName": "Identification of two additional members of the membrane-bound dipeptidase family.", - "textContent": "58", + "textContent": "109", "type": [ "PublicationXref", "PubMed:12738806" @@ -56241,7 +56625,7 @@ "id": "publicationXreffc2", "source": "Med Res Rev", "standardName": "Cyclopentenone prostaglandins: new insights on biological activities and cellular targets.", - "textContent": "55", + "textContent": "26", "type": [ "PublicationXref", "PubMed:11301410" @@ -56261,7 +56645,7 @@ "id": "publicationXreffcc", "source": "Arch Biochem Biophys", "standardName": "Carboxypeptidase A-catalyzed direct conversion of leukotriene C4 to leukotriene F4.", - "textContent": "59", + "textContent": "110", "type": [ "PublicationXref", "PubMed:12729612" @@ -56279,7 +56663,7 @@ "id": "publicationXreffcd", "source": "Essays Biochem", "standardName": "Specialized pro-resolving mediator network: an update on production and actions.", - "textContent": "153", + "textContent": "179", "type": [ "PublicationXref", "PubMed:32885825" @@ -56300,7 +56684,7 @@ "id": "publicationXreffd7", "source": "J Clin Invest", "standardName": "Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.", - "textContent": "99", + "textContent": "46", "type": [ "PublicationXref", "PubMed:21206090" @@ -56321,7 +56705,7 @@ "id": "publicationXreffd9", "source": "Adv Nutr", "standardName": "Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs.", - "textContent": "113", + "textContent": "172", "type": [ "PublicationXref", "PubMed:26374175" @@ -56342,7 +56726,7 @@ "id": "publicationXreffde", "source": "Brain Res Bull", "standardName": "Increased urinary F(2)-isoprostanes levels in the patients with Alzheimer's disease.", - "textContent": "63", + "textContent": "30", "type": [ "PublicationXref", "PubMed:15275956" @@ -56365,7 +56749,7 @@ "id": "publicationXreffe2", "source": "Respir Res", "standardName": "Prostaglandin D(2) metabolites activate asthmatic patient-derived type 2 innate lymphoid cells and eosinophils via theDP(2) receptor.", - "textContent": "167", + "textContent": "80", "type": [ "PublicationXref", "PubMed:34620168" @@ -56386,7 +56770,7 @@ "id": "publicationXreffe4", "source": "PubMed", "standardName": "Catalytic mechanism of the primary human prostaglandin F2a synthase,aldo-keto reductase 1B1--prostaglandin D2 synthase activity in the absence of NADP(H)", - "textContent": "98", + "textContent": "118", "type": [ "PublicationXref", "PubMed:21306562" @@ -56405,7 +56789,7 @@ "id": "publicationXreffe7", "source": "Front Physiol", "standardName": "Cyclopentenone Prostaglandins: Biologically Active Lipid Mediators Targeting Inflammation.", - "textContent": "158", + "textContent": "87", "type": [ "PublicationXref", "PubMed:34335286" @@ -56422,7 +56806,7 @@ "id": "publicationXrefffb", "source": "Prostaglandins, Leukotrienes and Essential Fatty Acids", "standardName": "Radioimmunoassay of 8-iso-prostaglandin F2alpha: an index for oxidative injury via free radical catalysed lipid peroxidation.", - "textContent": "44", + "textContent": "20", "type": [ "PublicationXref", "PubMed:9654406" @@ -56446,7 +56830,7 @@ "id": "publicationXrefffe", "source": "National Library of Medicine", "standardName": "Peripheral 8-iso-PGF2a as a Biomarker in Bosnian Patients with Alzheimer's Disease and Vascular Dementia.", - "textContent": "146", + "textContent": "79", "type": [ "PublicationXref", "PubMed:33370737" @@ -57559,7 +57943,7 @@ "c4c92", "b996a" ], - "dataSourceVersion": "WP5424_r129383", + "dataSourceVersion": "WP5424_r134273", "displayName": "Omega-6-fatty acids in senescence", "drawAs": "rect", "fill": "white", @@ -57569,7 +57953,7 @@ "height": 4206.829268292683, "id": "WP5424", "kaavioType": "Group", - "lastModified": "20240329185220", + "lastModified": "20240719070523", "name": "Omega-6-fatty acids in senescence", "organism": "Homo sapiens", "padding": 5, @@ -57578,7 +57962,7 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Omega-6-fatty acids in senescence\nLast Modified: 20240329185220\nOrganism: Homo sapiens", + "textContent": "Name: Omega-6-fatty acids in senescence\nLast Modified: 20240719070523\nOrganism: Homo sapiens", "type": [ "Pathway", "http://identifiers.org/pw/PW:0001253", diff --git a/pathways/WP5424/WP5424.png b/pathways/WP5424/WP5424.png index 84a255950..726eb497e 100644 Binary files a/pathways/WP5424/WP5424.png and b/pathways/WP5424/WP5424.png differ diff --git a/pathways/WP5424/WP5424.svg b/pathways/WP5424/WP5424.svg index 2a55a6d0e..3d55bba58 100644 --- a/pathways/WP5424/WP5424.svg +++ b/pathways/WP5424/WP5424.svg @@ -496,7 +496,7 @@ - + @@ -6104,7 +6104,7 @@ Name: Omega-6-fatty acids in senescence - Last Modified: 20240329185220 + Last Modified: 20240719070523 Organism: Homo sapiens diff --git a/pathways/WP5470/WP5470-datanodes.tsv b/pathways/WP5470/WP5470-datanodes.tsv index 978052d3d..2c052f2ec 100644 --- a/pathways/WP5470/WP5470-datanodes.tsv +++ b/pathways/WP5470/WP5470-datanodes.tsv @@ -26,7 +26,7 @@ GABRP GeneProduct ensembl:ENSG00000094755 "" ensembl:ENSG00000094755 ncbigene:25 GABRD GeneProduct ensembl:ENSG00000187730 "" ensembl:ENSG00000187730 ncbigene:2563 hgnc.symbol:GABRD uniprot:A0A1W2PQZ5;uniprot:A0A1W2PPH3;uniprot:A0A1W2PR72;uniprot:A0A1W2PRC4;uniprot:A0A1W2PP88;uniprot:A0A1W2PRY7;uniprot:A0A1W2PQT2;uniprot:A0A1W2PQR3;uniprot:O14764;uniprot:A0A1W2PPP1 GABRQ GeneProduct ensembl:ENSG00000268089 "" ensembl:ENSG00000268089 ncbigene:55879 hgnc.symbol:GABRQ uniprot:Q9UN88 PRKAA2 GeneProduct ensembl:ENSG00000162409 "" ensembl:ENSG00000162409 ncbigene:5563 hgnc.symbol:PRKAA2 uniprot:P54646 -PRKAB1 GeneProduct ensembl:ENG00000111725 "" +PRKAB1 GeneProduct ensembl:ENSG00000111725 "" ensembl:ENSG00000111725 ncbigene:5564 hgnc.symbol:PRKAB1 uniprot:Q9Y478;uniprot:F5H610;uniprot:A0A024RBN1;uniprot:F5H2X8;uniprot:F5H4Y8 PRKAB2 GeneProduct ensembl:ENSG00000131791 "" ensembl:ENSG00000131791 ncbigene:5565 hgnc.symbol:PRKAB2 uniprot:O43741 PRKAG1 GeneProduct ensembl:ENSG00000181929 "" ensembl:ENSG00000181929 ncbigene:5571 hgnc.symbol:PRKAG1 uniprot:H0YIC9;uniprot:F8VYZ8;uniprot:H0YHF8;uniprot:F8VSL2;uniprot:F8VYY9;uniprot:P54619;uniprot:F8VZX1;uniprot:F8VQQ1;uniprot:F8W046;uniprot:F8VVA3;uniprot:F8VRY2;uniprot:A0A024R125;uniprot:F8VPF5;uniprot:F8VSH3 PRKAG2 GeneProduct ensembl:ENSG00000106617 "" ensembl:ENSG00000106617 ncbigene:51422 hgnc.symbol:PRKAG2 uniprot:A0A494C026;uniprot:A0A494C1R6;uniprot:F8WDB5;uniprot:A0A090N8Q6;uniprot:A0A494C155;uniprot:A0A494C188;uniprot:F8WAY3;uniprot:A0A494C068;uniprot:Q9UGJ0;uniprot:A0A494C1K7;uniprot:E9PGP6;uniprot:A0A384MDZ2;uniprot:F8WDA1;uniprot:A0A494C0H7;uniprot:A0A494C094 diff --git a/pathways/WP5470/WP5470.gpml b/pathways/WP5470/WP5470.gpml index b8517fea8..87c6e3369 100644 --- a/pathways/WP5470/WP5470.gpml +++ b/pathways/WP5470/WP5470.gpml @@ -1,5 +1,5 @@ - + This ERK pathway is implicated in Huntington's disease. The ligands BDNF, EGF, and Glu bind to their respective receptors (TrkB, EGFR, mGluR) and start a signal transduction pathway starting with RAS and RAF1, which leads to the stimulation of MEK then ERK. ERK promotes function of MSK1 (a downstream kinase), ElK1 and CREB (transcription factors), and caspases 3/7 (apoptotic molecules). These downstream targets are implicated in producing the effects of Huntington's disease at the cellular level. This pathway is based on Figure 1 from Bodai et al. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3853 CPTAC Assay Portal] @@ -72,7 +72,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + diff --git a/pathways/WP5470/WP5470.json b/pathways/WP5470/WP5470.json index bfdf81082..eb68efa29 100644 --- a/pathways/WP5470/WP5470.json +++ b/pathways/WP5470/WP5470.json @@ -22141,10 +22141,18 @@ "type": [ "DataNode", "SingleFreeNode", - "Ensembl:ENG00000111725", + "Ensembl:ENSG00000111725", "GeneProduct", - "CompactIdentifier:ensembl:ENG00000111725", - "PRKAB1" + "CompactIdentifier:ensembl:ENSG00000111725", + "PRKAB1", + "Ensembl:ENSG00000111725", + "Entrez Gene:5564", + "HGNC:PRKAB1", + "UniProt:Q9Y478", + "UniProt:F5H610", + "UniProt:A0A024RBN1", + "UniProt:F5H2X8", + "UniProt:F5H4Y8" ], "verticalAlign": "middle", "whiteSpace": "pre", @@ -22152,7 +22160,7 @@ "wpType": "GeneProduct", "x": 12, "xrefDataSource": "Ensembl", - "xrefIdentifier": "ENG00000111725", + "xrefIdentifier": "ENSG00000111725", "y": 52.00000000000114, "zIndex": 32768 }, @@ -22681,7 +22689,7 @@ "a67f8", "d0df7" ], - "dataSourceVersion": "WP5470_r134261", + "dataSourceVersion": "WP5470_r134264", "displayName": "Effect of omega-3 PUFA on Huntington's disease pathways", "drawAs": "rect", "fill": "white", @@ -22691,7 +22699,7 @@ "height": 1700.0736606611679, "id": "WP5470", "kaavioType": "Group", - "lastModified": "20240718050900", + "lastModified": "20240719062924", "name": "Effect of omega-3 PUFA on Huntington's disease pathways", "organism": "Homo sapiens", "padding": 5, @@ -22700,7 +22708,7 @@ "stroke": "black", "strokeWidth": 0, "textAlign": "left", - "textContent": "Name: Effect of omega-3 PUFA on Huntington's disease pathways\nLast Modified: 20240718050900\nOrganism: Homo sapiens", + "textContent": "Name: Effect of omega-3 PUFA on Huntington's disease pathways\nLast Modified: 20240719062924\nOrganism: Homo sapiens", "type": [ "Pathway", "http://identifiers.org/pw/PW:0000017", diff --git a/pathways/WP5470/WP5470.png b/pathways/WP5470/WP5470.png index 75b3d4f07..9e7078e68 100644 Binary files a/pathways/WP5470/WP5470.png and b/pathways/WP5470/WP5470.png differ diff --git a/pathways/WP5470/WP5470.svg b/pathways/WP5470/WP5470.svg index f85b429e6..8d1720de3 100644 --- a/pathways/WP5470/WP5470.svg +++ b/pathways/WP5470/WP5470.svg @@ -490,7 +490,7 @@ - + @@ -1172,7 +1172,7 @@ PRKAA2 - + PRKAB1 @@ -2825,7 +2825,7 @@ Name: Effect of omega-3 PUFA on Huntington's disease pathways - Last Modified: 20240718050900 + Last Modified: 20240719062924 Organism: Homo sapiens