Additional Annotations

Intrinsically Disordered Regions

In addition to the default feature space, FAS can annotate intrinsically disordered regions using the tool AUCpreD from the Predict_Property package. If you are installing FAS, you can run fas.setup with the additional option --disorder to install the addon for annotating disordered regions. Alternatively, you can install the addon using:

fas.disorder.setup -p <installation path>

This script will install Predict_Property in the installation path. After that you can use fas.disorder.predict to annotate:

fas.disorder.predict -i <input fasta> -o <output directory>

If there are problems with the automatic installation of AUCpreD, you might need to install it yourself using the manual from the PredictProperty GitHub page. You can then run:

fas.disorder.predict -i <input fasta> -o <output directory> -a <PredictProperty installation path>/Predict_Property/AUCpreD.sh

To use the annotations with FAS you need to give an alternative featuretype file:

#linearized
#normal
aucpred
#checked