SchiSTOP model implementation

SchiSTOP (Beyond mass drug administration: understanding Schistosomiasis dynamics to STOP transmission),

a project funded by the European Marie Skłodowska-Curie fellowship.

Repository of code for SchiSTOP modelling framework: a stochastic agent-based (ABM) transmission model for the transmission dynamics of Schistosoma mansoni in human population. An ODE-based module for the infection dynamics within the snail intermidiate host is integrated into the ABM.

Detailed description of SchiSTOP has been published within the manuscript: "Revisiting the impact of Schistosoma mansoni regulating mechanisms on transmission dynamics using SchiSTOP , a novel modelling framework".

Mode of use

1. File 02.2_Setting_simulation_scenario.R: customize scenario-specific parameters. This will prepare the setting to run simulations.

2. File 05_Run_model.R : run the model and save results. The script allows to load input data, call previous scripts, customize the parameters for simulations, launch simulations with SchiSTOP from R source (04_Model_specification.R). Results are stored in two outputs:

   • population-level output, i.e. results aggregated at population level (e.g. prevalence)

   • individual-level output (optional), i.e. results tracked over time for each individuals

Author

Veronica Malizia¹

Supervision

Sake J. de Vlas², Federica Giardina^1*

¹ Radboud University Medical Center, Department IQ Health, Biostatistics Research Group, Nijmegen, The Netherlands

² Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

^* Project leader