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Breast cancer classifier based on silver-seq data

Please find here the data used in a breast cancer recurrence classification practice (Zhou, Z., Wu, Q., Yan, Z., Zheng, H., Chen, C.J., Liu, Y., Qi, Z., Calandrelli, R., Chen, Z., Chien, S. and Su, H.I., 2019. Extracellular RNA in a single droplet of human serum reflects physiologic and disease states. Proceedings of the National Academy of Sciences, 116(38), pp.19200-19208.): https://drive.google.com/open?id=1i-8qJifMFZ-71xtoaGCYlDuRY1-YWywg. You'll be able to find the following files,

  • tpm_96_nodup.txt, TPM values for the 96 breast cancer samples, data for the samples are organized in columns (C1 to C96)
  • readcounts_96_nodup.txt, read counts for the 96 breast cancer samples, data for the samples are organized in columns (C1 to C96)
  • patient_info.csv, meta info for all samples, the column recurStatus contains recurrence status of the corresponding donor, "R" for recurrence and "N" for non-recurrence.
  • preselectedList, the 750 pre-selected breast cancer biomarker genes in Ensembl gene ID

A tutorial is also provided below as an R program for your reference. The tutorial demonstrates construction of a classifier for breast cancer recurrence status classification.

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