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Reproducibility repo for Shashikadze et al. "Multi-omics profiling of lungs from genetically diabetic pigs reveals reduced ALOX15 levels and impaired eicosanoid switching as mechanisms contributing to a proinflammatory milieu".

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bshashikadze/diabetes-lung-omics-paper

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Reproducibility repo for Shashikadze et al. "Multi-omics profiling of lungs from genetically diabetic pigs reveals reduced ALOX15 levels and impaired eicosanoid switching as mechanisms contributing to a proinflammatory milieu".

Proteomics dataset can be downloaded from ProteomeExchange repository (dataset identifier - PXD038014)

Lipidomics dataset can be found in supplementary materials of the paper

R codes to reproduce the statistical analysis and visualization present in the manuscript

  • code to reproduce figure 1 (and supplementary figure 2)
  • code to reproduce figure 2 (and supplementary figure 3)
  • code to reproduce figure 3
  • code to reproduce figure 4
  • code to reproduce figure 5
  • code to reproduce supplementary figure 1
  • code to reproduce supplementary tables

Differential abundance analysis of proteomics data was performed with this code

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Reproducibility repo for Shashikadze et al. "Multi-omics profiling of lungs from genetically diabetic pigs reveals reduced ALOX15 levels and impaired eicosanoid switching as mechanisms contributing to a proinflammatory milieu".

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