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OUTRIDER > Overexpression of TBR1 not found #583
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Hi, I cannot access the link, it says: "Could not find shared item. It has been either moved or deleted, or the link has expired.". But, from what I can see in the IGV screenshots, the TBR1 is usually not expressed in your tissue, so it is filtered out. OUTRIDER can only model genes that are sufficiently expressed. |
Indeed, it seems the gene is only expressed in brain: |
Thanks for your answer! |
For this run, we add at least 1 control, we know it has an overexpression of TBR1. Won't it be enough to overpass filtering? |
It is indeed intended. It was a way we thought to overpass the filtering... |
It's not a good idea as it affects the modelling assumptions of OUTRIDER. You can change the filtering parameters |
Hi,
The attached ppt presents the case of overexpression of TBR1 due to a PSMD14/TBR1 fusion on patient 6624CY000185.
We ran OUTRIDER via DROP and this variant was not found.
You can find in that link the raw OUTRIDER outputs files and the DROP config file :
https://dispose.aphp.fr/userportal/?v=4.5.6#/shared/public/8c_Zd35P2Xrjz9lo/86866af4-a635-48d1-ad22-adcdd85abb95
Would you have any clues that could explain why the tool does not find the variant?
PSMD14-TBR1.pptx
Thanks in advance for your help!
Julie Bogoin
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