This repo contains a conglomerate of scripts to integrate proteomic and transcriptomic data based on a genome-scale metabolic model.

How to use

Here we have two use cases:

1. astrocyte_contextualization.m integrates the data to contextualize the Osorio model.
2. astrocyte_reconstruction.m recontructs a context-specific model of an astrocyte using Recon3D as the base.

Articles

Multi-omics integrative analysis coupled to control theory and computational simulation of a genome-scale metabolic model reveal controlling biological switches in human astrocytes under palmitic acid-induced lipotoxicity. (submitted)