Small molecule agonism of the glutamate receptor GluK2 expressed by dermal mast cells reduces their capacity to respond to MrgprB2 activation and suppresses skin inflammation.
- doParallel
- dplyr
- SLIDE
We thank Dr. Benjamin McNeil of Northwestern University for providing Mrgprb2-/- mice, Cara Donohue Carey, Dr. Lacin Cevhertas, and Jiying Zhang of the University of Pittsburgh for assistance in obtaining and processing human skin explants. We also thank the Division of Laboratory Animal Resources, Unified Flow Core of the University of Pittsburgh, and UPMC dermatopathology service. Work performed in the Pitt Biospecimen Core (RRID:SCR_025229) and services and instruments used in this project were supported, in part, by the University of Pittsburgh, the Office of the Senior Vice Chancellor for Health Sciences.
This research was supported in part by the University of Pittsburgh Center for Research Computing through the resources provided. Specifically, this work used the HTC cluster, which is supported by NIH award number S10OD028483.